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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717138">
        <property type="protein sequence ID" value="KJH40533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7L8"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13806" checksum="9140ADEBBFE13210" modified="2015-05-27" version="1">MAGNRNRISTIPPSLLVVEGVVQLPWIVMASTTMMKVSIVALVTVISVATYDDQNNIQEFHSAYKRMLVDPDYHIQLERIHPYFLDDMERLLRDYPNFISFLSNLLYSYHSLLLLTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8X7V0_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">DICVIV_14421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN721755">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <end position="53"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10433" checksum="70460F600F268FB0" modified="2015-05-27" version="1">MGQYKVVNKLLDYENVQNLTFTVVATDYGTPQLSSLQEVTVYIIDVNDHAPVLRSTDDVLIVNETAVSGTTLFQFHVEDHDSVSYFLIFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7W9</accession>
    <name>A0A0D8X7W9_DICVI</name>
    <protein>
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            <fullName evidence="10">Ribonucleoside-diphosphate reductase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_13394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KN717068">
        <property type="protein sequence ID" value="KJH40648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
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    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH40648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="803" mass="90781" checksum="F6E47DE5904601B4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8E5</accession>
    <name>A0A0D8X8E5_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719283">
        <property type="protein sequence ID" value="KJH39914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8E5"/>
    <dbReference type="OrthoDB" id="5824177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7357" checksum="7A7139834C3F0563" modified="2015-05-27" version="1">MRYVSIKLKPTSPVIISTADNMSNPWKSGNKTHIKEKVLIIQNYFCCCGYFNSSDWQNATEKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8H2</accession>
    <name>A0A0D8X8H2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA 3-prime-terminal phosphate cyclase, insert domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_14153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN719065">
        <property type="protein sequence ID" value="KJH39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="5">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="16861" checksum="670BE27599839E1C" modified="2015-05-27" version="1">MKLIENPVTVEKQGKICKIRGQAYITKVTPSLAYRVIDAAKKMLHGYISDVYITVDHRKGDVGGNDFSSPGYGLFLTAETTEGVIYHGEAISKPKGEAGDPSVAEDVGTHAAVALLEEIYKDSLTHRLRQLILHNDHYKLVFKTSLTLALSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9G2</accession>
    <name>A0A0D8X9G2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717441">
        <property type="protein sequence ID" value="KJH40264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9G2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="18832" checksum="09260CFD21105598" modified="2015-05-27" version="1">MVEIQETEITPTNFRRLSGAMYAITNNFGTRKAVVEVAALIRIMKMRCSCSRSHPCKPSLRERGQSWTKEQSHILKISLRKISKDCQTLSWIIDSKLPFRKDNSSANTITNNFGTRKAVLEGTVLIRIMKMRCSCSKSHPCKPSVRERGQSWTKEQSHIVERFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9K9</accession>
    <name>A0A0D8X9K9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_13744</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717381">
        <property type="protein sequence ID" value="KJH40314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X9K9"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="344" mass="40409" checksum="EDC410F8630B1E84" modified="2015-05-27" version="1">MLGVSLKRKPIALYNALFLRPIRVNESHVGAYVQWNRDVLSTTVHKKKFESTPNTFVRKSVPRKDAVTRMVFDMSPIMAKLKSIMSDFKPDGCLPREPLQRMYHALLNHRKTQLSGSQLQIMESLSLNQLLEIWKAQLFAIGEWMMHCEEFARLPLDEKLKMFKNSWMIWQRFERITMSIELFGWRAVNEKLLAISDDKAIVIDTVKFDFSSLTDHDPSYIRRIFEPFADRLTEEVTKSCLEVGLNIIEVVYVLCTLMWHVEGRFVNSETQAVAETYRERMSDNLHYYYTTILKAPNYAGRLIRLMTIVHCIENIHYERSKIMELARIFDIFKVEVSENGMFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBH9</accession>
    <name>A0A0D8XBH9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716735">
        <property type="protein sequence ID" value="KJH41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBH9"/>
    <dbReference type="STRING" id="29172.A0A0D8XBH9"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24138">
        <property type="entry name" value="TtcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="846" mass="96198" checksum="AF36F8D88A4CE1DA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBP0</accession>
    <name>A0A0D8XBP0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716912">
        <property type="protein sequence ID" value="KJH41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBP0"/>
    <dbReference type="STRING" id="29172.A0A0D8XBP0"/>
    <dbReference type="OrthoDB" id="5865181at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836560" evidence="3">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="44"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="30865" checksum="53BDC3D1876A13B6" modified="2015-05-27" version="1">MRILWLLVLIPPVLSENITAEENEALKHECGYHRLPENSRQVRSIGGKDAEKNEFPWIAAILQTREGQRSTQRGICSGVQISRIHILTAAHCLVKARQGVDCMRYDLLPLSDITIYAGSSCLEPLTCPTTKTEYHPKEILIHPDYDPCKSRSDFALITLTTNISKTDGLPICTPSKEGDIPKNLTAIGFGIDTTQKSVPKLRSVELSFRKEIKKDKLITTRDTGKSTCSGDSGGPLVRINSTGTYFVIGTTIGSNPKCNVKRPLTEGVCPLPETDEVISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBT2</accession>
    <name>A0A0D8XBT2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716713">
        <property type="protein sequence ID" value="KJH42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBT2"/>
    <dbReference type="OrthoDB" id="5812894at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="22563" checksum="74DC2A73773F42FB" modified="2015-05-27" version="1">MHGLEEKKVREGTSGKYICPPLPNQINPILIDGHQTVRSLAFMNFSYRMIRYLVLAAIALTVSFAYPATGGLDVDNLSANGKKFFMDMTKQVMGVPSLKPENLAAQSFFRSFLDKYTKLDEKTKKDMEQHVPTATKIFNEAAQKYNVDPHKAFQMLSTFFENFKKGEKRRAEPRCPEDDYRHSCHNEHIQPRKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCF0</accession>
    <name>A0A0D8XCF0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dicer partner-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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    <sequence length="287" mass="32937" checksum="60879657DDAAC14C" modified="2015-05-27" version="1">MDRIMREPKDFQPRILGLTASLINDKTPPNRLEEKLSKLERVLNSAIETASDLVAVSKYGSRPSEIVVSSSSYELSGSCGGDILQILEIWRKFCSSTQEFDPNFDIDPRKPIQEAFSRTLAVLRQVGPWAAWKVSQMWEKELHKLTRQSFLQEKTVDFLLMGETCMTIVRKMLEPKMRSIRSLEGLKPYLPNKVVRLIEILSYFNPESRTTQSPLCGIIFVDQRYVAYTLNVLLKHICRWESRFKFIQSDFVIGFSGGSFASDDSQGLHKRQADVCYNIKAFISLHN</sequence>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </evidence>
    <sequence length="135" mass="15023" checksum="E556A9C9391B161C" modified="2015-05-27" version="1">MSGDLQLNDIGENSVIGSLVLFLFTDDSASLYRTSLNQNNLISETTLLCNCFFKPEIRLQNDFEHHVNPVDKEDDTHELGKSLIPICCVSFATILLFLIAVTQPQHDSINQSSQLSVIDPHISLVIIITVLLIDI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <source>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716551">
        <property type="protein sequence ID" value="KJH43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFZ8"/>
    <dbReference type="STRING" id="29172.A0A0D8XFZ8"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF285">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28243" checksum="920441020EABC1AA" modified="2015-05-27" version="1">MCREVCILPSGGVSSLPAAFLINQLLDVMQKQRKDVVPSCTVHPSEQLLYCESCDLVFCQQCEISVLKLQSFKNNFLPLNVLCLKFFYFDISSQKCTQHTVIPLSIALKRMSEIVVYRAKGRLRALDQAHVCVSQEIEQLDKNVDKILDQINCTFQEVTNTIENRRRDLIESVRIRRDEKRKVLKDQIEAITDEKKKLVKVIFMLLLGCFFYTKFPIFIPFSDVIFRICFLFSVLSYLQKIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGI5</accession>
    <name>A0A0D8XGI5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_10292</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716534">
        <property type="protein sequence ID" value="KJH43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGI5"/>
    <dbReference type="STRING" id="29172.A0A0D8XGI5"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="17350" checksum="2648FC24A2C3E9F7" modified="2015-05-27" version="1">MLARSIPHITVLTRRHLATATATMTPEKNVEELRLTFASPDMAFYNSEVVKQVDVPTLAGMVGVLANHVPTIGVLKPGVVSVTDLQGNISKHFVSSGTMSMNIDGTCQVLAEEVVKVEDIDQAAARAELEAAQRASVEGSEIAKAEAQIRAEVADALIKAATGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGQ4</accession>
    <name>A0A0D8XGQ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716528">
        <property type="protein sequence ID" value="KJH43768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGQ4"/>
    <dbReference type="OrthoDB" id="5875185at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335816" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7262" checksum="8BED6DFEC0E942D2" modified="2015-05-27" version="1">MAPPRLFLILFMCILLTTCSSTQADTTKDKKKGMLMSSNGPSYMKRTHFILRRPNRAMALLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGW4</accession>
    <name>A0A0D8XGW4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716606">
        <property type="protein sequence ID" value="KJH42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGW4"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10230" checksum="E4AE91CB00095C1C" modified="2015-05-27" version="1">MRAIAKTQKERHLLQHRACLTEREANKDKLNVHNEKIVIEDKAICMVCKEAILCNNALIYLKTGYLIHSKCMKYPNLCPITNAILIPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHX0</accession>
    <name>A0A0D8XHX0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716492">
        <property type="protein sequence ID" value="KJH44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHX0"/>
    <dbReference type="STRING" id="29172.A0A0D8XHX0"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22016" checksum="036C9B1F60F49234" modified="2015-05-27" version="1">MVMARIFGRIVLCNIRQIANIRIYPSLLVRTSPYVCFNKRFSSNVERHEFQAETRNLIDIVAKSLYSNSEVFIRELISNASDALEKRRFAELSGQLGEGPNEIRITTDEVNRSITFEDSGIGMDRSDLLECLGTIAKSGSKEFIEKNKDNAEAVIGQFGVGFYSSFMVADSVIVTTRKIGAPDENGLKWIWNGCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ59</accession>
    <name>A0A0D8XJ59_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716522">
        <property type="protein sequence ID" value="KJH43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ59"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13645" checksum="19A5A1F541B73FD5" modified="2015-05-27" version="1">MENVVSNLLQNILKIVDSWWKTLPKDENLVGLKPQEMNKPMIPFLQMVNGRTNKVGCAYHICGQDYYDQYVQPFILFVCKYGHPLIKIGDPIYTVGPPCDSCKNRCLHGALCDTMFGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV6</accession>
    <name>A0A0D8XJV6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NUCB1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_09846</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJV6"/>
    <dbReference type="STRING" id="29172.A0A0D8XJV6"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335694" description="NUCB1-like N-terminal domain-containing protein" evidence="15">
        <location>
            <begin position="26"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="NUCB1-like N-terminal" evidence="16">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH44129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="386" mass="45417" checksum="BDE55E2CA2DDF83E" modified="2015-05-27" version="1">MNLCICLLAELFMVVVAPPPQRVQAEQEALSFRQGSTSSPNDGADSNSKEKIHNGQKPLYEFTYSKYLGEVVSILENDPKFSERLRGMPEADVKAGNIADHIDDLDEHVFDKLTKAKLDEIERLRQQIQKQIEDDGGAHNVKMPEHLDVTNWEKFSKEDLRKLIIRTVQDMEIMDQERKKNFKEYEMQKKAEEDHKLAQMNEEERQKAIREAEEAKKRHSDHEKMKHPGSRDQLEEVWEESDHMDKDSFNPRTFFALHDLNGDGYWNEDELEALFQVELEKVYNETNPDDDPRERYSVFFQLYLNCIIFFVGMTYMLYRMEEMYRMREHVTKQMDKNGDRLISLEEFLSDAEAQTPNVDPGWKDLSENQVRYCPGSFFICSPLFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKY0</accession>
    <name>A0A0D8XKY0_DICVI</name>
    <protein>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMD9</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </evidence>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11297" checksum="913830DFE727BC4D" modified="2015-05-27" version="1">MENMTDKKQTRAIFLLEFKIDHKAADTACNINDACVPETWYLKKFCERDERLEIEECSGRHRKFTTTNREQSSKLNVLRLRNVTDNSTLCGRPPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
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        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45252.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="356" mass="40850" checksum="73408DB35D9581FB" modified="2015-05-27" version="1">MKTTMASAIPLLKTCLSILEEFSSNQKDNEEFINLLEVEPSKQQRLRQQSLSGKKLGSSMMLVGVLLVHSFYSKSYFHLMVHLFLNIEGVCLNLHAAHHRPVCFICFKIFVRHHHSNMLFDWAKALLALFVLLKSYFNPKNQVTVTQIRETLMTDVFLNGLEYRAPSTILSTLCHYHILESWLVLLIRSYEHAMPLLSMMEGNQWSSQNLILSRTLLISLLIAPVIENFSPSMSVFNYFFFDFPNVGAVIRDRARMLVEPLVNEVMNVNSSGHKERCVNHLSNALYNIADIHPDNFQDILDKILLMTRNKKAKVRHRSLLVIGAMFDKVGDSVAPYLPMIMPFLSELLEGILIIRL</sequence>
</entry>
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    <accession>A0A0D8XNN0</accession>
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        <name evidence="2" type="ORF">DICVIV_08571</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="516" mass="59441" checksum="3A337E0AE7D1DE68" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNR1</accession>
    <name>A0A0D8XNR1_DICVI</name>
    <protein>
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            <fullName evidence="9">Probable ATP-dependent RNA helicase DDX46</fullName>
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        <alternativeName>
            <fullName evidence="10">DEAD box protein 46</fullName>
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    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_08518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716408">
        <property type="protein sequence ID" value="KJH45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XNR1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="319"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="925" mass="104847" checksum="FF2B2753221E32C1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPX9</accession>
    <name>A0A0D8XPX9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716474">
        <property type="protein sequence ID" value="KJH44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPX9"/>
    <dbReference type="OrthoDB" id="5864338at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="36479" checksum="5A239213A90999FF" modified="2015-05-27" version="1">MLRSSYIDPSQPLIDYSPPTKWPRATTPVNVRSVDPSILGTSSDSGVGLNLTFNSPPIVNRMDQNRCSPGLRTPTSRPGIHMSTTPSPFRSFRLSSFTSPTLSDRALRLSNSENVVGFRYRDGSIEKNVKIADMTTPRHSGIVGPLKVSRQIDDSGLFGSDVDHYTTSTPLQSSPQSYLNCSTSTAVVHNPYADICRSSKEEVPSTVTVTKSSPPTPSSFKRAMRDVQRQGMLQPRKLLTDNTNIPMMDKEFPEKQLPLMKKIEEDEVVNRQRGCSISETFNVPRKPLKPYSRRWMRLVTGGTRSQRELTAAAHSFIARLPHINNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ33</accession>
    <name>A0A0D8XQ33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_08113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716383">
        <property type="protein sequence ID" value="KJH45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ33"/>
    <dbReference type="STRING" id="29172.A0A0D8XQ33"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="25 26">HannoverDv2000</strain>
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    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716326">
        <property type="protein sequence ID" value="KJH46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQP2"/>
    <dbReference type="STRING" id="29172.A0A0D8XQP2"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJH46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="21054" checksum="1290B17748FA771C" modified="2015-05-27" version="1">MVIEMDACPESDALKASGNYEVKCVDKKIHDNDDDDDIQSRYMDELRMEFASLSTLTNFNRVADEVKPLYATPEKIVCEMVVKPQNVNAKGTLHGGQTASLTDIITARAIGLTIRDQAMASIELSVSYFLPVKLGDVIEITAHVLKLGRNVAFTEAEFRRKSDGKLAAKGRHTVAILPKQPQADGQKVAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQY9</accession>
    <name>A0A0D8XQY9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LSM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQY9"/>
    <dbReference type="STRING" id="29172.A0A0D8XQY9"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9410" checksum="F218B9517FC81274" modified="2015-05-27" version="1">MEYVAQYMGRWMEVELTDGRIIRGQMLCTDKQPNFILGRSEERWSGETGEPRAIGLAMVARQHVVRLKLLPTPRHSNTEAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRE6</accession>
    <name>A0A0D8XRE6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716436">
        <property type="protein sequence ID" value="KJH44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRE6"/>
    <dbReference type="OrthoDB" id="407555at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="19770" checksum="8A72B250F3A5E2D8" modified="2015-05-27" version="1">MKVNEEEDPIRQRLGGLKLSDGEQREVYSAAMVIQRAYREYRARNANRRQADSERNAAVTIQSCYRRYKQFCYFKKLHNAAIVVQKHFRLKKMNHTGISSCSLNEVPEHPTLNGQSIRIQVPQNNSCLLREHRAATTIQLAYRGHRKRQAAARKIQKFMKESRMKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRZ6</accession>
    <name>A0A0D8XRZ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716423">
        <property type="protein sequence ID" value="KJH45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRZ6"/>
    <dbReference type="OrthoDB" id="5802415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="31738" checksum="BB98094E33864142" modified="2015-05-27" version="1">MPSISAALIEATCNKDPSDELSNRSKIRSRFFLWNRSWKGPLSTLVTQFYPHHLKMMVLFVIAALHLAYARDFLLAFRSFESLANQVVFRVSPNIKNHDDFHLVQLVMVTFIDYKKNLWMTVGAMCSSLSTSAIIVFLYNVYWPSMNNVTKSIVCVVDMVAYLSLTFLLGARMMIVLNLINYIEPSLQAASRLVPTSDFMNELRCSIIANDSLPLCSVVLERSIFPLIILKYLIVLCVLTFVYILLAYVIEYCIRHWFPPTDQDELLPKTRTLVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS44</accession>
    <name>A0A0D8XS44_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_06589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716312">
        <property type="protein sequence ID" value="KJH47340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS44"/>
    <dbReference type="STRING" id="29172.A0A0D8XS44"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="143"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="351"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH47340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="483" mass="53115" checksum="04DE279D601133F4" modified="2015-05-27" version="1">MIAFVLAELANEFHQVVTIEVEDVNDHAPTFPKDSFKLEISEFARIGAAYPLPRAEDPDGLNFTVKRYRIVQGNVNNVFKISTRSIHDELYAELVVNGQLDREYRDKYDLVVEASDGGKPTKIGRLLVYVVILDANDNAPIFAQPRYSISVPANLTIGSQILLLKATDGDAGDNGKVRFRLQKTTSERKSFFSLSQNGLLSSAVRLLPGTVHDLVVVAYDGGVPSLETTAIVTVTVLGHSLTPPPIDIIWLTDTGTAYFLENITLGTIVARLSLSDEQKNSVITLTGCPSLCLRETQTSSTYLLLVCGIFDREISSEYHLKFSLRKGTELVLEHPVVLSVGDINDNAPVWPQIYAHITINRSTSVDDQTAVLVANDADQGLNGRVRYAVLDSDVVTIDPDTGRLTVLKELDCSLGSEIRFRVRATDNGVPSLFSDLQVTADLDDSYGRPPQFEKSLYEIKIPEDSYVGTCLLRVCVSGLKYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS84</accession>
    <name>A0A0D8XS84_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS84"/>
    <dbReference type="STRING" id="29172.A0A0D8XS84"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18656" checksum="4DB2D4F666421DED" modified="2015-05-27" version="1">MFENILLARINVARKIGFHKNHDTNNGTEPGSGRVSGKDSHSASTQPTSRSTNTRGGRAMVTSSTSDPYVEKLRVVKPRVYKRRWAILVMFILLSASNGAQWIMYSVIAQIVADFYNVSFSAVDWTSMIYMATYIMLFIPAAKGDTSANEVACSSANEYLSSALSSKANL</sequence>
</entry>
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    <accession>A0A0D8XSC1</accession>
    <name>A0A0D8XSC1_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Hydrolase, NUDIX family</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="408" mass="47232" checksum="67E45C4A502102A3" modified="2015-05-27" version="1">MTLLKREQFLFTDMVISDEEDYIAESRDPTPEPTPEFIEISDSPGQGILKNGKLPHVEEKKHLEGEIFSEERAPDMQLGTGINIIYDELSTKYLSSGWHNAAFIECRYVRLHDNVNYVAAGIILRGDAYETTEVLLIQEAKKTCYGKWYMPAGRVEAGETLENAVKREVREESGYECDVVELLSLEVQGSGWYRFSFYCEISGGTLKTQPNQESLGAQWWSIDDVLEKKLQLRVKDFLRLLEQGLAYRNMQHYQVPRILPLNVNVPGLFVEFMIVRHSLDESRTEVLVHKSIKDEQMLTEHDQPFPTVEFGFEYFFAMVVSKVYRHLLEEGGNVVFAPSHVVRIKCHPNPIQSLAHGLSVRLYCQHKKCATKAVIRSPRYHWIPVDNKSIREQLYMEKYQYRPSLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT50</accession>
    <name>A0A0D8XT50_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_06927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="156" mass="17978" checksum="5C19A5870A8C1579" modified="2015-05-27" version="1">MGVQSSRYGDCCIVSAVIYSAEARPWRFLKMLMSQQKKFQYRAVSHPIQYSRQSRNIRRVLAMIAASWMVSLLVASPMVFGVNVRPPDANSHECRFYNAEFSIGSSIISFVIPCILVLFVYIRILITLKRREKAAKLRRMKKFQIGARKNLELSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTI2</accession>
    <name>A0A0D8XTI2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTI2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9180" checksum="768394B1EEE44569" modified="2015-05-27" version="1">MMECPSVICHRTGICSDNAVRNRNTKTMKCGALLCPSGHRLSKFSKNILLQAIHIPYGPRLQVMCNFRKGNNVQNGNESVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUE6</accession>
    <name>A0A0D8XUE6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716278">
        <property type="protein sequence ID" value="KJH48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUE6"/>
    <dbReference type="STRING" id="29172.A0A0D8XUE6"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="62" mass="6777" checksum="F6654B138FC1A598" modified="2015-05-27" version="1">MCNKLLDSMTCCEHQAELFCRQCHCRRYGPKGVGFGIGAGSLTMDTGEQFGNKEVDMTSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUI6</accession>
    <name>A0A0D8XUI6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_07896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="KN716372">
        <property type="protein sequence ID" value="KJH46046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUI6"/>
    <dbReference type="STRING" id="29172.A0A0D8XUI6"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="176"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH46046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="449" mass="50995" checksum="11DB96CE9EAC6399" modified="2015-05-27" version="1">MKDIEDDFDICTAKGSRNIGEFQVKIRSRRNIVELGQLDSFVPGVSSVWVKTWGCSHNSSDSEYMTGLLSEAGYPIVKHPCDAKIWILNSCTVKTPSETQASNMLQEGRKQGKFIVMAGCVSQAAPNEPWLRDVSIVGVKQIDRIVEVVEETLKGNVVRLLSRKRPDAILSLPKIRKNELIEVLAINTGCLNHCTYCKTKMARGDLKSYPLEELVHQARTAFERDGVKELWLTSEDLGAWGRDINMVLPDLLCAIVEVIPDGCMMRLGMTNPPYILDYLEDIAVVLNHPRVYSFLHIPVQSGSDAVLRDMKREYTSSHFKMIVDFMLKNVPNIYIATDMICAFPTETKEDFEESMELIRKYQFPSLFINQFYPRSGTPAASMKKISTAEARRRTAAMSTLFREYSRYKPQRIGEEHEVLICEKASGHVYWFVQTNILLDLIMVVILIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUL1</accession>
    <name>A0A0D8XUL1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="11047" checksum="61379F9015667E84" modified="2015-05-27" version="1">MPQDYTAVELDPNTPPPYMDPTNSIAKKKSMVIHKKSVEHHGKRCEHCGQFAQQPVVIWPAPRPHDHIRPDNTKFIGYVILIAVVIFLLFAACKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX30</accession>
    <name>A0A0D8XX30_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX30"/>
    <dbReference type="STRING" id="29172.A0A0D8XX30"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="96" mass="10756" checksum="6FC0DC69D804F910" modified="2015-05-27" version="1">MILRERATFREILLAPILISGLLGRVDVKATTEGSGGITALPRAVRHGIALGIAALYPEKMEPLRISGLLSYDPRRKERNKVNQPGARAKWIWYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXD1</accession>
    <name>A0A0D8XXD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic initiation factor 5A hypusine, DNA-binding OB fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716324">
        <property type="protein sequence ID" value="KJH47011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXD1"/>
    <dbReference type="STRING" id="29172.A0A0D8XXD1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0385">Hypusine</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="11874" checksum="3356698CBC1C6A1A" modified="2015-05-27" version="1">MADGHHDDEHFASAESGAAATFPKQCSALRKNEHVMIKGRPCKLMSIDEGFCSLMDPETCDLKDDLKMPEGELGTQIKEALDKDEGSVLVSVVSACGEEAILGYKISTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXG0</accession>
    <name>A0A0D8XXG0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="KN716265">
        <property type="protein sequence ID" value="KJH48512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXG0"/>
    <dbReference type="STRING" id="29172.A0A0D8XXG0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="7 10 13" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="29"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="102"/>
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        <ligand>
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            <position position="250"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="12">
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="308"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="433" mass="49060" checksum="B192FC2220F5AB7B" modified="2015-05-27" version="1">MITISIEFSGNPSEKEEKNEMVAKIKGGSIVEMQGDEMTRIIWDLIKEKLIFPYVDLDIHFFDLGIENRDKTEDQVTIDAAHATLKYNVAVKCATITPDEARMKGTVFREPIIVKNVPRLVNSWSKPIIIGRHAHADQYKATDFVVPGPGKLEIKFVPADGSAEIKHDVFNFKGPGVSLSMYNTDDSIRDFAHASFKYALQRGYPLYLSTKNTILKKYDGRFKDIFAEIYKEYESDFKAAGIWYEHRLIDDMVAQAMKSAGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQHQKGEETSTNPIASIFAWTRGLSHRARLDNNTELAKFAQNLEEVCIETMEQGFVTKDLAICIKGSKMLMHEILKQPKQSIWSEIYWILLVYIVINYNQATKNYIVCGLVRFTKFTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY19</accession>
    <name>A0A0D8XY19_DICVI</name>
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        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716258">
        <property type="protein sequence ID" value="KJH48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="288" mass="32624" checksum="223403C20B53EDBC" modified="2015-05-27" version="1">MRHVASSLSKSRDNKTTVEHSQNDKDCSVMKKKRRKESRRSSSYSDSDSSRSSRSKSQLFSRSSRKPSRRRRKRVRSSSSSSRGTYDGFDFFLPEDECPYACKQCHRGFYTVKELAEHEIRAHDMKIPCAHCDKNAISVTKLAAHILFRHPSQEVECYYCDEMFGAKAEKLDKSAWDEFRAHVYKEILKKKVYEHTSKSKGGPSEAVALRGIGKCPHGAAVKCKNFPNCPGAKCIYSHGQCRYDITCNKSTCPFDHSNRPRVCMACVNDMKESLCKSLVNGVDGGTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYB7</accession>
    <name>A0A0D8XYB7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYB7"/>
    <dbReference type="STRING" id="29172.A0A0D8XYB7"/>
    <dbReference type="OrthoDB" id="5773944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="395" mass="46054" checksum="3DD5899D17EF8166" modified="2015-05-27" version="1">MLNYTYKRAHNFLTQSIRFNSVQAEKNLKLAVLRRNWSVEDLQRLDEVVDIEFRRAEEENQQALKKSLQIPDGLWKYQRIEQLKRWKTIPAIKYATFEVKDSLNSCLSDFLGKALHFHDDDNTDIVLSNKPPVLHWTITPLDTEVQIVIRISFPLVGPDQATFINIQNSLRNYFNSAYEWTQGILLTADVVRLHIERVHRTVIELSCRICEDELEDDQVSTPTKLLWPYLAIALKNTLNEINKHQYLQYTLELIPFGMCFFKPPLKVRVFDLSLFMATAYEYGKVSFRYQDELYDIILEKLLPDGTFVSLDQLLSVKPPKLYKQQMNTIDSDKSVTRESNRDSTTSTAQLSVNHNRGRRVSFGSIKLIDDVTKPVKGVDEYVDEMLKQTMDHLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYW9</accession>
    <name>A0A0D8XYW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Choi Y.J."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJH50415.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="182" mass="19789" checksum="14BC9787D2730086" modified="2015-05-27" version="1">MLRLQIEIAKRCGERVPETWGVDGGGRVSTNPEAILDGGGLLPLGGSELTGGYKGYGLGALVEIFCGILAGAHWGPHIRKWMSAVVEADLGQCFIAVDPEAFAPGFHERLQEFINTMRNLPQVDADHGLNVEVAGDKEKKHIKVVEQLGGIPYHPNQIANAEKLAEKFNVKKLEIIKEVKEV</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="15"/>
            <end position="34"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50520.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="75" mass="8690" checksum="C66535DE226137E2" modified="2015-05-27" version="1">MGTTALPVITYKQHISVFLHFFWRYFIPIILLITSTKCQSGVMSNLFRPTDLWGPLSIQNKKISEYDEKAARITI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein srb family.</text>
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        <property type="protein sequence ID" value="KJH48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10509840at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002184">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS BETA-1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS BETA-16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMPROTEINSRB"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="31111" checksum="36C0384FABBDF609" modified="2015-05-27" version="1">MLLRALKATRSLLLGCNGNIVNHADLNTWKKAKIDSTLLSCIRSTMNKADIDLECRTKGLDVVEYPLYRVFQVIYIFLSLTSFPSLLFVQIKYISSSIFHQNIKIIFLMYYSLALLHSVSYSVSEIYTLITSLIAEPCHFFAPTSIHATLQLCVFTANSGLVFSLVALCCERCVATIRSNKYESNGVTLGIVLVFLTIFGIATVMFYVYDVKDFDIKTWAIGILPPGSVKEFNRVAIAYIVVSSLSILTFFLLSRINRRRCSMWVYFHQRYFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1V9</accession>
    <name>A0A0D8Y1V9_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1V9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1V9"/>
    <dbReference type="OrthoDB" id="5844508at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="516" mass="59150" checksum="F4EC105A807D2608" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y235</accession>
    <name>A0A0D8Y235_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5794962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13302" checksum="FEFFE276531F6C61" modified="2015-05-27" version="1">MQTLRAYLIVYIIILTFQFTAIVCNGLLLFLFFKEKSLQRNSSMRLVLFLVATTFSLAITTLPYSIYLTISWNPFYINLNPYITMLCGAPLIFHLKIDLTLIESLAVERIMARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3J5</accession>
    <name>A0A0D8Y3J5_DICVI</name>
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        <submittedName>
            <fullName evidence="7">Phorbol esters/diacylglycerol binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716244">
        <property type="protein sequence ID" value="KJH49156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="426" mass="49467" checksum="8F53B4639CC7F93D" modified="2015-05-27" version="1">MSSVSSNVSIRSEIPIRKDSICEEPSPVDDELSEVIALCHSEKPDCTRNDEIMAAICHCKSKLKECLYDVEIPNKQIYFDKLVQLSLEKQELEENDANISTGVTKILGHEFVLQRSRGRRNPYCEVCIGTIWRLVQSWRRCRVCGFRAHEKCVNGVHRVCAGIAISRNDFCFSMEFCEERGLCAQNYACAECDAPLQYEGPSNAQPRLCEFTGLLFCSKCHWGDLWSIPARIFHNMDATPRPVCRAAKQLLAIVDIRPLINMSLANPSLFKYHKELRRVQLLRRNFLFMKCYFICCRNAAKLRILQYLNRHQYFVDGADMYSLADLRELCMGDLLQDLEDIYAVFRRHIEEECEICRGNGFYCELCDGSDGRDQIIFPFSKKVSMCQKCFAVFHSKCFETHNSFCTRCERRKKRELARQQLFEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Q9</accession>
    <name>A0A0D8Y3Q9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716185">
        <property type="protein sequence ID" value="KJH51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Q9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Q9"/>
    <dbReference type="OrthoDB" id="5871193at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF153">
        <property type="entry name" value="SERINE PROTEASE HEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="16737" checksum="B1E0F2447C744985" modified="2015-05-27" version="1">MISDEGHKKPSNEDVIDMLSVCQILLTKLKCHFTQNVFKDNLNVNKVMGGRRATLGELPWSILIETTDKLIICGGTLIGRKHVITAAHCFWKNSDVETCTPKDMYRIEEVRRLMKVMVGGICRKIDEKNDCSDAETVRGLNVMQPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3S7</accession>
    <name>A0A0D8Y3S7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_02270</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3S7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3S7"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="596" mass="68272" checksum="FC995B7009B5CA0E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3U6</accession>
    <name>A0A0D8Y3U6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-KW"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="316" mass="35547" checksum="F965848521F70004" modified="2015-05-27" version="1">MMLSVVPFIYVGYRICRTILALIKAIFIYLLAPLFYSPNLKPYVNRWTVVTGCTDGIGKAYTIELAKRGLRKFVLIGRNQTKLSDIKTYLELSFGCRVKTYVFDFSKDNYDELRKFVSDIDVGFVVNSVGVGRENLERYGDNPDADRQILKVNGLGAAEFLSLILPTMEKSGGGQIVVLSSSQGYRPIPYLASYSASKAMMSFLCECIDREYKTISVQCLTPALVATKMVYYEKGSLFVVTPEQFAKEAVNSIGLTARTSGCFNHELQLLAMHLFPWTILKHLIMPIYYHQRRRMTLLHAAASAEKQGVTRMSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y4D5_DICVI</name>
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        <submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="83" mass="8908" checksum="8F62666FD04F6EDB" modified="2015-05-27" version="1">MLAAVVKEFGGPEVIKILSNVPIPVIQSSDQVLIRVSAAGVNPVDTYIRNGQYPVLPSLPYTPGRDGAGIVEKATLFSFRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4H7</accession>
    <name>A0A0D8Y4H7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716234">
        <property type="protein sequence ID" value="KJH49471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4H7"/>
    <dbReference type="OrthoDB" id="10549748at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="170" mass="18723" checksum="62E132C0DCD2FD17" modified="2015-05-27" version="1">MIPCFLAPPTPQFYHHVTTAQHASMAMRPSAPGAVMAWPTAPPVGPKYRPPSPLRDYKNPVAVFSKIVRKVRKHILSSEEGQKSEIGETERSAAHGKTVVMEESTVKSQMTQMHSVKSVTRSPDESKITSGKSPDSRITAENSATEKKDTSVCESVMRRKPSHSKGRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4N4</accession>
    <name>A0A0D8Y4N4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716231">
        <property type="protein sequence ID" value="KJH49531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4N4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4N4"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="234" mass="27547" checksum="78BB5F8F2E21AAE0" modified="2015-05-27" version="1">MSIRKNGYGNQFGIADTNCTINVKWLPITELRNGRVRLLRAGSARKYKCRARCVNYLDEEHVAFEAWHDINEPTMFNYGMYLNKEDYLIYSYANRRVEERLERLRYFSEKSKNAKYHPHVHIILIDSVASSQAIRALPRTVNFLTNAMEAVQFRKLNKVGVNSRPNGFVMLFGKTTEPVMREMVDMEPIPADWTYSTYCRKYLDETIYIPNQYRNAGYKRSIFEQPDIPHTYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5A6</accession>
    <name>A0A0D8Y5A6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_01896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5A6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5A6"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="99"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="26714" checksum="8B6BDBAB973E67E4" modified="2015-05-27" version="1">MKHVFRLLTENGQFLVRVTEPRKDMGFRTVLSSRWQDKNYHFVIGENRGNYFIDKETFPDINTLIQYYVREHKPLTEKSGVILLTPVMRQKWELKHDWITLDRFLGEGEFGEVYAGTLNLGMNTYKVAVKVHKGSSLEKEAIAEICKEARIMRHYRHENVIKFYGVAVEKDPLMLVMELVSGGALDNLLRSKKDDLSQHELATSVMLIILDLIGTNLTAHERRKRNMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y659</accession>
    <name>A0A0D8Y659_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y659"/>
    <dbReference type="STRING" id="29172.A0A0D8Y659"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25108" checksum="75CAEEAE2AECDF75" modified="2015-05-27" version="1" fragment="single">ANKILGQYYDRSIQLFFLIVSVITHVVLHCTKKKTCATVDSRQKGGTTVVRKSLTPIIMDRTQRNFTEKTSRDHTLKEDKTQEMHKTEDEMNIKSALKLETMVTGDKKVKESEDIMNASATKHMKTAVEVDEQHSLEMYKTACSNEEYETAYDGELGKSSQASFNCSFEFCKKVKRISNVSICTEAQASTAVKLTELVIRVLVLQEFIPQLLHSSEDGIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y6M5_DICVI</name>
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        <name evidence="4" type="ORF">DICVIV_02175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716179">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
    <sequence length="215" mass="24819" checksum="1093E52BA0CC86D4" modified="2015-05-27" version="1">MREDVLLRKLLADGEGTGEERRFQLLNGCFRSLRNANTVSKAEAVKALRLIDSLELSMRKQREIAEMTKRQTKEYEEMAERVDKEIAISREKMTQAKVDLAAARLVRKNRKEYALLVGMIEDLPSRAETTRKLDEIQEELTQQQERQQQLEARLSERRNHLHALNIILANFQKLLADEDNELSNDTPSTEIGEKDDGDDEEHSHRERSCDTADVG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="24352" checksum="E415DD72ACCCF960" modified="2015-05-27" version="1">MSNAVPILSMLTKNNNLSSVSGTQGDLRNRVWDAWLTETGKRLHIGFRKISRILAWETALLKMIEPTKAVATTQTDPSEIESLFVGTNGTLSHTSAESNNVMSVAVDPPATAARQPAWAAAGITQTENDFWHRHKNVADMVIKANKTVSEFLSQLSRSCFVPTRRNRRYDFSSSTMTKSAQQMADEIFTGFFRDMKWECNKLSKGKPTPAMEFVISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8C5</accession>
    <name>A0A0D8Y8C5_DICVI</name>
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        <name evidence="7" type="ORF">DICVIV_02976</name>
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    <organism evidence="7 8">
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8C5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8C5"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16148" checksum="C566C036766C3C98" modified="2015-05-27" version="1">MFGIEVIWSSLWKMHSLNQFHHQVEDAMLMFDKATQRHRGFGFITFDNDEVSDKVCEIHFHEINGKMVECKKAQPKEVMLPVQLNKSRAAAARNLYGIPPEQLLAYATYLPRFGYGNLLYPNMTSSRPMLLKCAPSLELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8U1</accession>
    <name>A0A0D8Y8U1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8U1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8U1"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="858" mass="98476" checksum="292E16906DC602CB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y916</accession>
    <name>A0A0D8Y916_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y916"/>
    <dbReference type="STRING" id="29172.A0A0D8Y916"/>
    <dbReference type="OrthoDB" id="10063940at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="10">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="226" mass="25811" checksum="C57EFBAF25BC6933" modified="2015-05-27" version="1">MESGWSTDNVVFGAGGALLQRIDRDTQKCAFKCSHVVVNGEQRDVYKNPATDEGKRSKKGYLTLELNSSGNLNTVEEGLGDPEKDLLQTVYEDGHLLVDWTLDEIRERAEIDLVKTWRQTLHVNGFSGTSNDKYISGWGPGGQKVNTAQNAVMLRHIPTGLVVKVQESRLLPKNIEIAFERMKHALDRYENGDNCYEEQYKRLQRRKEAKVNCKRKAQRQMRKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9V7</accession>
    <name>A0A0D8Y9V7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phorbol esters/diacylglycerol binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9V7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9V7"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C1_nPKC_theta-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase C theta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="166" mass="18982" checksum="468060E8F468C965" modified="2015-05-27" version="1">MKSDRKRTVCAFADEDENPVDDAGMTSRTTSGPGLQRRRGAIKHARIHEIRGHQFVATFFRQPTFCSLCSDFMGLNKQGYQCQLCSTAVHKKCHEKIIMHCPGSAKNTKETIALKERFKVDIPHRFKTYNYKSPTFCDHCGSMLYGLFKQGLRCEEWGSFDSEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBA9</accession>
    <name>A0A0D8YBA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBA9"/>
    <dbReference type="OrthoDB" id="5876333at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="15043" checksum="E4D6176CEB549A90" modified="2015-05-27" version="1">MGDVEALEVLSSVVDNETSEVRFKMVGSEAAEVPHRKFQSSNMEATLRRTPAMGLKAEARKISYIRNKRLQHHPSLVSCRSINVYRRALLNRIHQNALKSKKRNNSNSVKQWTEGVINRISFNRLFKNHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBB1</accession>
    <name>A0A0D8YBB1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBB1"/>
    <dbReference type="STRING" id="29172.A0A0D8YBB1"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF334">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="146"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="296"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="561" mass="60784" checksum="65AA6E724BD058A2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBX1</accession>
    <name>A0A0D8YBX1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBX1"/>
    <dbReference type="STRING" id="29172.A0A0D8YBX1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="71" mass="8150" checksum="5E0EB30CE5E87311" modified="2015-05-27" version="1">MSYVDSMGFDALKELYNDAKKDDIILQYCGLNSEVLSVIENDEILRTSIPQWVFRRSVNEALLHLDSIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD81</accession>
    <name>A0A0D8YD81_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD81"/>
    <dbReference type="STRING" id="29172.A0A0D8YD81"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF34">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="19314" checksum="68FDC6C55C84B00A" modified="2015-05-27" version="1">MGIFQEKTNMLCGDMLFSGHTLIMVSCALSIAYYLPQKWRHLQWIPHFLAIIGMACMIISRTHYTVDIFIAYCLTNFIFRIYHAFCEVDIFMERRKSVLYGLWMLWIVEWLEDDIVPGRVENKFEFPLDGLLRVLIRSEAMKHHKQISIVICALNTHVLIAAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF09</accession>
    <name>A0A0D8YF09_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF09"/>
    <dbReference type="STRING" id="29172.A0A0D8YF09"/>
    <dbReference type="OrthoDB" id="5862271at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="478" mass="55358" checksum="D0FA755BB2FDBF9E" modified="2015-05-27" version="1">MKLCRQILNIGIAARFMCRYVVDILAIHGICAHLPPPHPFCAVPPPMEQPHRDPRANLMHCEQWAARQFDQAVLPSLLSTPFHHVTRTVIDPYKQIHMKILKAAGISDKGERAALVNGVKILKEVTSYMEQFDRPIKKEKFKDNEGKEHEKHTKQKPKKEPLLPWTDCPEDEFCIVTDRTIEIDKNDLTQKGNKVAVAVKSLRLICTDKDQRLPWVAEAEMSHQLNHPNVVRFYGFTFETADSNILMVFEMMDKGALDSFCRKINYQISVNEMVDWLCQIARGMAHLHAQIPVIVHGDLAARNVLVCSHPIDVTRYVLKITDFGISKRTRRETFATYDDPNKIPFKWLPPEVLKSREMTPKADVWSYGVLVHELYGIGEPYGMMGPEKVIHALNDGHRFERQPKMPHFIYDVVLQCWRRLPLDRPHFREIELYLLPHYIENEATHMKIISERLRKQQEAVVKKSIGKDLGINDLIDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFZ9</accession>
    <name>A0A0D8YFZ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFZ9"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336425" evidence="3">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18174" checksum="3818AE43223F81E1" modified="2015-05-27" version="1">MDKWAAQLLLYPLIYALHENDSSGNSSTAEDTIVTSTDIIDNNSTTILTTYSTTNISTTNILRTSSKTFSYINDWQTIGIRIGVGGICAFGFVALFTCLYYWFSSGSNKRRSRRRRIKSVSLEDECQEHYLVEENDDSQIGTSGTGPTPTTPFVERKISSNTI</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="RLI1"/>
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    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14152" checksum="F15084345200666A" modified="2015-05-27" version="1">MLDEPSSYLDVKQRLRAASLIRDMISSTTYVIVVEHDLAVLDYSSDFICCLYGVPGVYGVVTLPSGVREGFNMFLDGFIRTENMRFREDKLSFKVSEQIDEVVKRTGNFKYPSMTKTLYHSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5Y4</accession>
    <name>A0A0D8X5Y4_DICVI</name>
    <protein>
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            <fullName evidence="8">Astacin</fullName>
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        <name evidence="8" type="ORF">DICVIV_14195</name>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN719339">
        <property type="protein sequence ID" value="KJH39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="21429" checksum="EE0FF0D25681C035" modified="2015-05-27" version="1" fragment="single">DPNAADTRRFLQQLLTMEGEIDEQLALSPEQQKDLAEDMKYFVNVGMDHIQAHGDSIEEVNHYSHVDRALYQGDIMLTKEQGDEILEDIRNNENNNRTKRQAYRDWRFPNRLWSDGVFYSFYNASEDAKRVFRKAAEIWENSTCIDFKEDDQATDRIVVLNTSGCWSIIGKIGGPQDLSLGDGCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5Z3</accession>
    <name>A0A0D8X5Z3_DICVI</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719288">
        <property type="protein sequence ID" value="KJH39913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5Z3"/>
    <dbReference type="OrthoDB" id="5874762at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9375" checksum="CFA0534407C4F990" modified="2015-05-27" version="1">MTNCFIIDDTVTTLCDRQSCSISPPSSISPIPLPYLEIFVSLKITNAAMASWTSRLWRTLLNRATRSLSSGPYGEDFKTASVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6Z1</accession>
    <name>A0A0D8X6Z1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <begin position="12"/>
            <end position="37"/>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH39992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8233" checksum="FFE74291EF92DCE8" modified="2015-05-27" version="1">MINGNSQMTSDGDRITTFNVTMLSPLSYTAVLVKEQNIEKKALGANALLYREMTNLRQQLSVLFIRQKGSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8G4</accession>
    <name>A0A0D8X8G4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">DICVIV_13203</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
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            <name>Zn(2+)</name>
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    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KJH40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="372" mass="42793" checksum="9048D939AC888AB7" modified="2015-05-27" version="1">MLEFVTKHGTSDGIDPAYNRHYGYRPETDAEKTKQVFGKSYSKIDDGVDQLDLPYQQQTDMGMYQGNIMLTEEQKEEISNNTEANRSIRNKRQAYRNWKYPRTLWKGGVVKMRSVCSKKLSRHGKMRHALTSRKITQLRIKSTSFMNMDAGQELEQLGFLLTMASYKTTELLSHIGKAIHEIGHALGMFHTHTRHDRDDFFILIEENFRKGWKNQLDKEPKDRNYNYEIPYDYGSVMHYGSRMYVYVLNKAPGGCGGILNATNTYETFNVSMGDSRLRSAKDEPDKCTYWIQAPVESTIHLTLNSYDGDVSSDSCVYSGVEIKVMEDKRLTGYKCLLLRFCSKNSSGTVMVSKDNLVIVTIYNRLLTNKVTL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716991">
        <property type="protein sequence ID" value="KJH40858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="20547" checksum="79215E158AD8EFE5" modified="2015-05-27" version="1">MVYWDDNKWRRIFDRVKYFLARGRINQHSLPSMKNMEDFLKITTSTLFLGFCCNLPSVLACGTDPFRTEKTLKFTVSNFNVPVEMAYSTEDTVRVQAPSIRRRKEDVEMFVDSLVKEAVTAVFEEEGRNYFLLPAVVTAILDQITVKIQYDPILCNKALVDQPLNTNLQRELLFWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9D9</accession>
    <name>A0A0D8X9D9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxo acid dehydrogenase acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716882">
        <property type="protein sequence ID" value="KJH41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9D9"/>
    <dbReference type="STRING" id="29172.A0A0D8X9D9"/>
    <dbReference type="OrthoDB" id="5858321at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="4">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="4">
        <location>
            <begin position="139"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="29161" checksum="9607A15DA942C1EC" modified="2015-05-27" version="1">MSLQNGVRADALMQIRLDLKDFANERKLKLSYMPFFIKAASLALTEFPSLNALIDEKLENVVYKASHNICVAMDTPGGLVVPNIKHCEQSKDVISETGDAKEEATYTSKQNVTTVDNSTITRALLTENREDIAIPAAGSIFDIASELQRLQEDGMRERISREDLTDGTFTISNIGTIGGTYASPIIFPPQLAIGALGKIEKLPRYDSNNSLVPMHIFKVSWAADHRVIDGATIARFSNRWKFYVEHPSAMLAQLKLTTITEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9M9</accession>
    <name>A0A0D8X9M9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cathepsin propeptide inhibitor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717351">
        <property type="protein sequence ID" value="KJH40334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9M9"/>
    <dbReference type="OrthoDB" id="6270617at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29457" checksum="8D968C35540CB6A2" modified="2015-05-27" version="1">MRVTVNFPSQKLPQVHHSIHHSDCLQTHYHFISKHQGDDFQRLGQNDENHYVPLIASYTLVEKHSRIIRQSATKNEARCSLIPPSKRWKDDDPIHTLYPVPPISLHLNIPLTFCIEIFISNIVSMNDNIEGTHSLPSIDCHSLFGAYGMRRTLLAAVFITTSFATVFTGGHTHSLLQKENLMYKWYPTEDSIYEDHKGNGNLKEYNENLERIFEELAKYENEQENKERLGKNFYNNVFKNIRRHFVDDYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9V3</accession>
    <name>A0A0D8X9V3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716840">
        <property type="protein sequence ID" value="KJH41370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9V3"/>
    <dbReference type="STRING" id="29172.A0A0D8X9V3"/>
    <dbReference type="OrthoDB" id="5871812at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002619">
        <property type="entry name" value="CX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520:SF8">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47520">
        <property type="entry name" value="CX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01705">
        <property type="entry name" value="CX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CX" evidence="3">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="32141" checksum="8049B3E0C914AB81" modified="2015-05-27" version="1" fragment="single">NPGGFQPQSNHGGFQQPGGYHPQPNQGGFHPQGGYQPHGGFHPNQGGFRSGTGIGSSSSSGTFKKALLGGALGAVGGLVAFEAGKAIIQSATKPFNYGGHDYYWDNHYQPKNNEIVCSIPLSQLQQLTSTTTTTTTNSPGSPLESTTISSASQPDQILNNLQFVDGTRPKQLTWGCRKGVEVCCGTDCCPAPANNMGNTYAGSGGAQNMAGVAFGIILLLLLSCCCCGFVAYKCCRSSIENFLPQNSNKQSVPPTGDYSQQYPLQQYPTQTYPPNQGYPMNVGYPQSGYAQPNYPQSYPHPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAQ6</accession>
    <name>A0A0D8XAQ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Fumarylacetoacetase</fullName>
            <ecNumber evidence="5">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KN717041">
        <property type="protein sequence ID" value="KJH40709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAQ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XAQ6"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="10761" checksum="6FB9315A65350C17" modified="2015-05-27" version="1">MKHLYWTLKQQLAHHTSNGCNVKPGDLMGSGTVSGPLMLSVSLIGFSQGNEGSYGSMLELSWRGEKLVPVGNQTRKFLQDGDEIILKIVSKNTPMRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9803" checksum="F156CC82BC6C3FDD" modified="2015-05-27" version="1">MRAQMVGCPRFIYEKEITALFSLIRLFISFIFVQDPNASSYAGQLYNGLYAYARALNLTLQRDPSAFRNGTQILENIAMTFEGQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB65</accession>
    <name>A0A0D8XB65_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716980">
        <property type="protein sequence ID" value="KJH40894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB65"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7452" checksum="D00EA8DC943A2FCE" modified="2015-05-27" version="1">MVNRTDTLPQGSELESRFHRNKELDLKYRCTTSFNQLRPINDRDSSIFEINPSTRASRLLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBL1</accession>
    <name>A0A0D8XBL1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716892">
        <property type="protein sequence ID" value="KJH41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="418911at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="390" mass="45101" checksum="43045DE726809DA7" modified="2015-05-27" version="1">MDWTRAQEVMPTFTAMEISRFLSLTSLDFNNYYSNGDPRRCPERSILFKANRVLESRLDYLISRRSSFEDGPLNNQLFEVYRKLGHVAVLAQDWAKALSAYQGAYKLQPFDYWKDPGAYFGLGLVYIHFKEFKLAADSFSRLLYSFPNLDIIVEVKARLGVCYQNLSDYTRALKFYNQALSDSSETPFLSKTHIRFNIALSNESAGDLAKAEEEYKDILAELAESLSHQQDRQYTQEQTRLVAAVNRQLGWISYRFNYPEQSEERAHRLHDAELFLQNSKKFEPINGKTYYYLGRCYGETLNKAHDAFLNYRHSIDKSEADADTWCSIGVLYHQQNQPMDALQAFICAVELDPEHSAAWTNLGVLYEVHAQFNDALACFRNAIKFNPGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBW2</accession>
    <name>A0A0D8XBW2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718942">
        <property type="protein sequence ID" value="KJH39956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBW2"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8158" checksum="747798A23727C3CD" modified="2015-05-27" version="1">MFDGYAKLIPLTFLLGFYVSNVVASNIKDTIAGVRGVAVLHVALLPLPCLSILPCRVFFSAFIVETMNVFEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC94</accession>
    <name>A0A0D8XC94_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716835">
        <property type="protein sequence ID" value="KJH41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC94"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6680" checksum="29EB9288264BE064" modified="2015-05-27" version="1">MLKHGYLENGSSVGRRTRLNKLPPCFVSRHCSYYAIRIRFDHVMTVHQLDIKLINGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCG8</accession>
    <name>A0A0D8XCG8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_12685</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716847">
        <property type="protein sequence ID" value="KJH41344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XCG8"/>
    <dbReference type="OrthoDB" id="5771911at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="52"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50144"/>
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        <source>
            <dbReference type="EMBL" id="KJH41344.1"/>
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        <source>
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    <sequence length="1022" mass="116486" checksum="9F160FAB7DD14A68" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the EXO84 family.</text>
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    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="209" mass="23627" checksum="10FF4F23A72FDF2E" modified="2015-05-27" version="1">MHLAAELSQLLLVCCWRAHKHVSLTLGWIVTELCPLNVLTTEDVHHIGAYYWRQLTECKHCGAFETSIKGYSLYSFSLCCVSICGIVKMLHFLDRSNGSMKFFMLLKEKKLFANCLYVDLSTCLCCFLFYYALLVEFCRGVPYLIATILATEPLNHPSQSLNIAMTSLLEMDQKSVRCRIHSLNVLKVLFSTAALGERVTPALEVGYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCX7</accession>
    <name>A0A0D8XCX7_DICVI</name>
    <protein>
        <submittedName>
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        <name evidence="2" type="ORF">DICVIV_12391</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716786">
        <property type="protein sequence ID" value="KJH41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCX7"/>
    <dbReference type="OrthoDB" id="10254686at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="15184" checksum="D58028D1F1C72F60" modified="2015-05-27" version="1">MIQIIAPSIDNDVEDQRLLPKCAEDVEHVTSTALWVLTNGETVTDEQLLRDRSSSEIEDSSSKGVTDSSSDNHCPASPSPNKEKWRNKPLHVEISMDTDVYVPDSPKMADLFEAVTRQDFNCIIYVEDTQFIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDJ2</accession>
    <name>A0A0D8XDJ2_DICVI</name>
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        <submittedName>
            <fullName evidence="9">Chitin binding Peritrophin-A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716749">
        <property type="protein sequence ID" value="KJH41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDJ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XDJ2"/>
    <dbReference type="OrthoDB" id="5914859at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="334"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="569"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="775" mass="85436" checksum="7BA82CD667FE8CF8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE58</accession>
    <name>A0A0D8XE58_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717049">
        <property type="protein sequence ID" value="KJH40691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XE58"/>
    <dbReference type="OrthoDB" id="411632at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF16">
        <property type="entry name" value="HTRL DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09612">
        <property type="entry name" value="HtrL_YibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39544" checksum="193507B2BCF9B9CF" modified="2015-05-27" version="1">MIKNFRTKVIIGSSSTTSGKTTFSIGSKTTHKLPVYDGTTKERHHHRHHHTLAHAEYHFMVPVPDTSTSQPRIHMTTHSLASDLTTKRQRIDVHRSLPTQVPHIVNINKEKAIYDVTTMGRLPFTSTSTMTSEESDDFTIVTALIDIGRGEWDRYRRPLEQYHLFMENLLSLQNNMIIFTDTSSYDFIHKYRKNMGEMHHTKIHLITLDDLPLSRHLDVVSKLIEDEHRDEQSWHSIWDPAMKDHPEAKSAKYDVLVNSKTYFLYNATLEDPFSTEFFVWIDAGYGHGNQSVFPYNNKWKPRFPRNKISLIKDSGMGSTSVNIYVEDSRHGCHSLKKETNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEP5</accession>
    <name>A0A0D8XEP5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_10881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716590">
        <property type="protein sequence ID" value="KJH43130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEP5"/>
    <dbReference type="STRING" id="29172.A0A0D8XEP5"/>
    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000918">
        <property type="entry name" value="Myosin Light Chain Kinase related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="41"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="753"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="970" mass="108705" checksum="09F68D23F4445835" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF32</accession>
    <name>A0A0D8XF32_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716578">
        <property type="protein sequence ID" value="KJH43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF32"/>
    <dbReference type="OrthoDB" id="5874014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008569">
        <property type="entry name" value="DUF851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05867">
        <property type="entry name" value="DUF851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="324" mass="36478" checksum="3B127CF3AA668482" modified="2015-05-27" version="1">MLFEPPSSRKTSEPHREPSSIKERLKRGLRTALNAFSRASFEQAFQSAKAKVGFVRGRGIFYDYQDSYLGGGQDDEDDSEEEADMEALTDTTHRPDLILVTTNHTNRGRIFNEKGTPFWKDKMFREELPKNRRKPLSSLLFQLADKKLTLKDPVATPAKIDGLEDLNNIKKRDTKHFNEDLLLSNTVRSIIGTLDGLDDYAKKQPQTIRRLEVVEPKTATNYARHVKFHEIHHPNVNEVVPFVYSGLGVCKTTNKKSKKSSSSISTSSSTSTDSIKSAKKRKKKKKGKAGDIEGVDACSDRVGIEKQILMNLVYIGQTLDFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFE9</accession>
    <name>A0A0D8XFE9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_10628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45244"/>
            <dbReference type="ChEBI" id="CHEBI:62243"/>
            <dbReference type="ChEBI" id="CHEBI:85108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45224"/>
            <dbReference type="ChEBI" id="CHEBI:85090"/>
            <dbReference type="ChEBI" id="CHEBI:85091"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716567">
        <property type="protein sequence ID" value="KJH43360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFE9"/>
    <dbReference type="STRING" id="29172.A0A0D8XFE9"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF2">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH43360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="299" mass="33193" checksum="3B571A5C87C3F455" modified="2015-05-27" version="1">MFKLLTNRLRYGCLALRHSGTLIKQKAGLEVYEASTHVYHIKLNRPHCRNTFTLELWKNMELIFGELSDDPNCRSIVISGIGKSFCAGIDLQQGMRDLTEVLMNDKVDIGRKGRALRNIITICQDGFSAIEKCPKPVIAAIHSHCLGAGIDLVTACDIRYASSDSIFSIKEVDIGMAADVGTLNRIQKIVGNDSWSRELAFTARDVGAEEALKFGLISRIFDTQESVVQGALALAERIAKKSPVGVQGSKVVLNYARDHTVEDSLNFVKTWNMSQLQSMDLRNSAMAVLNKQKLEYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFW6</accession>
    <name>A0A0D8XFW6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716647">
        <property type="protein sequence ID" value="KJH42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFW6"/>
    <dbReference type="STRING" id="29172.A0A0D8XFW6"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="478" mass="51960" checksum="B62167E9388289AC" modified="2015-05-27" version="1">MVSWMRKNLLLVMTVGSVIAGALLGFIIRPLNLSPQAIMLASFPGELLMRMLKMMILPLIISSLISGLSQLDAKQSGKMGSLAITYYFITTLIAVITGIILVLSIHPGDPSIKQDLGEGTEGKKVSTLDTLLDLLRNMFPENIVAATFQQAQTKYVTVRPKILKVNDSIHLEMLNNGTLNYVKAALEYNDGINVLGIIVFCIALGISLSQLGAEADVMIQFFVIMDKVIMRLMITVMWYSPFGIMCLIMGKILEIQDLADTARMLAMYMFTVLAGLAVHSLISLPLLFFLTTKTNPYTFMRGLLQAWITALGTASSSATLPITYNCLEENLGVDRRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGINLTFAQVITVSLTATLASIGAASVPSAGLVTMLLVLTAVGLPVKDVSLIVAVDWLLDRVRTSINVLGDAFGAGIVYYYVKEDLIAHDRLHPMRTLSMGKSSSNNQTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGA7</accession>
    <name>A0A0D8XGA7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716627">
        <property type="protein sequence ID" value="KJH42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGA7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335605" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9113" checksum="27AF06E277D0121B" modified="2015-05-27" version="1">MTDFIPLVISICIPRTLCWVIVTSKLRQYNNEDWFLNFEVLELTARTRLCNHRQNPGEHQICLDDLLIAQLPDALSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGC0</accession>
    <name>A0A0D8XGC0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">DICVIV_10321</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716537">
        <property type="protein sequence ID" value="KJH43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XGC0"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd05748">
        <property type="entry name" value="Ig_Titin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000504">
        <property type="entry name" value="Bent, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002083">
        <property type="entry name" value="Protein CBR-UNC-22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000003">
        <property type="entry name" value="Titin isoform E"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000127">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000249">
        <property type="entry name" value="twitchin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000567">
        <property type="entry name" value="Uncharacterized protein, isoform G"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000051">
        <property type="entry name" value="Uncharacterized protein, isoform J"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="55"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR E75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="220"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="461" mass="51490" checksum="1229B3F20BFCD499" modified="2015-05-27" version="1">MTHAGASTAAYAFAALMGCGSPNQPTFSMESLLKSELSDFSLKSVAANEESTICSVCCDEASGRHYGVVACFGCKGFFRRTVRSGKNYICRYDQKCRIDKENVCITAGRNVCRFCRYQKCLDVGMEPDGLFSYYSKTHSSFGLNFLSIRPDRDKTGRQKNPRRNGTHVIDSFDPVVKKFSGTSVFGEMPCVNKKDDSDENPTSPSSCTEFAPAGDTRSNSYDEILTTLREIEQICLQLRDVTPVSPVLRSSLISFVQRPSLITPRSQMFFGVSNGPASFPVFVENVRRMIVLVFDYANTLKPIADILPEEKYLSKHKVCFAVWIWNRAVLEKLEFGRRKPNSAVRKALSDHVLHQFNKLHVSETEFLALKAILALDPNIKGLSRKSSEQLLVGRESVQNALFSHLMIRYNAAEATARFGHLLLLIASVTKVSSMIVGLLQFARDMSLPIDSLLDELLLKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHD1</accession>
    <name>A0A0D8XHD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium / potassium ATPase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716588">
        <property type="protein sequence ID" value="KJH43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHD1"/>
    <dbReference type="STRING" id="29172.A0A0D8XHD1"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF52">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="33507" checksum="C8F45BD7715E96C1" modified="2015-05-27" version="1">MTKDVDQVSAEGPKKSDGSEFRKGFLGWVMSFVYLFIVWMFGLAFSISVMLILLSGLKEKPHYFGRGTHIGGTPRIVFEPNPNRFDILTRSVIRFRPRDPKSYENHMIRYKMLLRDEYNNTSTSKCTSVMGAFSGFPTNESVCHMEAGDPNIYGVCALTLRNINRGMGFSRRRPCIMLRLTRIFGWYPNDSDNLPNQQCGMGVTDCCNKRRIRFTCNSKKPINMDIYPKDGMSTCAFPFWNQVGYEQPFVMLRISNLTTGMHEIFCKPNLKSIAKLDNHKENIVRIAIDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHE4</accession>
    <name>A0A0D8XHE4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716506">
        <property type="protein sequence ID" value="KJH44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHE4"/>
    <dbReference type="STRING" id="29172.A0A0D8XHE4"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="10534" checksum="EBE7769E5A907BEE" modified="2015-05-27" version="1">MRAVNIMLAKDLFQSFDDKLKFENLFYGVQSWQLLELATTIPVVFVKIVGTHNSANEVFHCVHFECPADANALPPDDRSVLPKDVVVNEEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI64</accession>
    <name>A0A0D8XI64_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_12003</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716723">
        <property type="protein sequence ID" value="KJH42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI64"/>
    <dbReference type="STRING" id="29172.A0A0D8XI64"/>
    <dbReference type="OrthoDB" id="9995605at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="23117" checksum="1560FA182B21D08A" modified="2015-05-27" version="1">MVPFLSREFLKPPPFEVPIFRKSHAALFRKRPAHLIINRIKDYFHFYFIGLGILPVIICLTYNHIVYGTCELKDYPEKIRNIFFWNISLKGDPPHYWQFERTPVRQWWAKHFGISDIEHHERNLAYFEKLGIQARWRQIEQRVMHLEGERWDYKAWNYQPVSASWVDYSRWHALRLRDQYEQHGHYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIP9</accession>
    <name>A0A0D8XIP9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class II Aldolase and Adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716538">
        <property type="protein sequence ID" value="KJH43654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIP9"/>
    <dbReference type="STRING" id="29172.A0A0D8XIP9"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000013">
        <property type="entry name" value="Class II aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="471" mass="53116" checksum="876B330F56D95E15" modified="2015-05-27" version="1">MTTRSANLSADRERPFRFDPDDPEYIKDLQRPAVIKEDLTEMERRKRVQQLLESKKFCKELEEVKYTAEYIRDSATTIERLLQVIRQESDSSRSDSEHLKTIQRLSELTISNGAVSFANLHSVAGSAIPIADLKGNDKYTRQEKLLRNKLASLYRLVDLFQWSQGIYNHITLRFPNDDNHILLNPFGLLYHEVTAGTIVKVDLHGDIVDPGTTKLGINQNEFLVHSTIHSARPDVRCILHMQTAVVSAVASMKCGLLPLCQEAMIIGPVAYHDYEGSLDDEENRKSLVKSLGDKNILIWRGDGCIVMGETLEEAVLLMRNFVVACDHQIRAARAGIDNLVIPDEKTVERAYNYARNTGNGGEVNRSPVKDQAGNIISWGIGELEWEAWMRVLDHAGFRTGHIYRQSLLRNKFSMAPSTVNNNDVALPPATSAVGLVRGALLFQSMLFLVFDKDYYRSQVSVGNVKRFITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJF2</accession>
    <name>A0A0D8XJF2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuropeptide-like protein 29 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716663">
        <property type="protein sequence ID" value="KJH42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJF2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335960" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9137" checksum="A954EAD289E9BBCF" modified="2015-05-27" version="1">MKIFVVLIVAIVFISSTSCQYGYGPYGGMYGGGPYGGYGPYGGMYGPYGMNRGFYGGYGMRRFGGGFGRINPLQGAMMGAMMGAMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKX9</accession>
    <name>A0A0D8XKX9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJH45278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="30836" checksum="6691339BE0112D2B" modified="2015-05-27" version="1">MACSQVQEQVLSMELDRGGDFDFSNCIRNMALAKMGGIAPKVRSTGTTIVASTYKGGLVMGADSRATAGNIIADKHCEKVHYLTDSIYACGAGTAADLDQVAKMLSGTLRLMELNTGRKARVITALRHAKQHLFNYQGYVGAYLLIGGVDPTGPHLYECSANGTTMAKPFAAQGSGSYAAISVLERDFKPDMTASAINSAKLLEDDAVNLVQRALHAGMHADNASGNSLNLVIMRPGKTEFRGPIIPDFCKKPEPVDLSYKFKPGSTKVLKRKTIKFDIIESMDVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN88</accession>
    <name>A0A0D8XN88_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAM91 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716522">
        <property type="protein sequence ID" value="KJH43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN88"/>
    <dbReference type="STRING" id="29172.A0A0D8XN88"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
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        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="422"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="537"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="90817" checksum="B9264A5197F0FEF2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNA8</accession>
    <name>A0A0D8XNA8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNA8"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="19360" checksum="8FFA1C111F8EDA89" modified="2015-05-27" version="1">MEELCWAENFGEIMCGARRRAALERVSNLLDTELQRMYSEGRADAQICSTRQITTNENETQGGSREQIRAHYIRRCRRQTFTFRIDFQELKTFTLNVLPQQKCDVGKIRKLTLVEFIEYLYYKINDAINSLDGGQRRGYHRLVRFQQKTKDKAPTAKSKENAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNA9</accession>
    <name>A0A0D8XNA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716520">
        <property type="protein sequence ID" value="KJH43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNA9"/>
    <dbReference type="STRING" id="29172.A0A0D8XNA9"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="573" mass="64591" checksum="011AEB055A82C326" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP06</accession>
    <name>A0A0D8XP06_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_09859</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KN716498">
        <property type="protein sequence ID" value="KJH44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP06"/>
    <dbReference type="STRING" id="29172.A0A0D8XP06"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="168"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="320"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="623" mass="70253" checksum="A750081647BDC179" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPJ7</accession>
    <name>A0A0D8XPJ7_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_07460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716351">
        <property type="protein sequence ID" value="KJH46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPJ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XPJ7"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF42">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="532" mass="60466" checksum="B27B460082DFA303" modified="2015-05-27" version="1"> </sequence>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="SAM" id="Coils"/>
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    <sequence length="226" mass="25572" checksum="F8CDCDC40B699E76" modified="2015-05-27" version="1">MPLSPVSSIPEMPLSSCLLTSPLCVESKVTGQQLYMNQEALNHMQACQNEAFIWRTKAAQLEIVVKDQLAKANRIEEALRAELLAAKTRQSSNVSVSTKSTMTGDDDINTNTLIRISPIPYECFTQSCVEQKKNLTEENNRLLNQIEEANVKIRELEEDVATLRNELETTVDHRDKLKHQLENATEECDSKTAEIAACNIVLARHQLLCFKESIVSQMFVNVFREF</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">HannoverDv2000</strain>
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        <text evidence="8">Belongs to the nanos family.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <sequence length="78" mass="8526" checksum="C0734B57624EB7A2" modified="2015-05-27" version="1">MESNMPERKSLLSNKELMKGAISESSGVLLPSDVPKFPSRLQAAVLPIIDCHECVKSSPIYSLMSNSSFCAGYLQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716375">
        <property type="protein sequence ID" value="KJH45984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQB1"/>
    <dbReference type="STRING" id="29172.A0A0D8XQB1"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="14479" checksum="293AD08A65E901A7" modified="2015-05-27" version="1">MISYNATISEEDRLIFEILNLLENIYKINMGIICPIVWGEKSKEIYEKRNKFGSTLNRTTPEQVLELLDGKKMWRTVLNHTRFPLNNDKKVPGLYDVRFLLRVFLSLIHAGSEVSVKLRHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQN8</accession>
    <name>A0A0D8XQN8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716371">
        <property type="protein sequence ID" value="KJH46072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQN8"/>
    <dbReference type="OrthoDB" id="5794962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF3">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="187" mass="20986" checksum="5BDF05DEAF533133" modified="2015-05-27" version="1">MYLDLSPHFVMISSTPVVIQLKIHLTLTISIAIERILGLSYPIVFRKLSSYSCAKFCLLFGILLGAFDVILGFKLSSFHRVPNCAANGCFISDQYRYYVMSIIAIVLITVVLKKLQIVHRRRTQCGLSTNIRRRYLRQANRTCIGILFISLVFVTIPSVGVGFGEMFGYSIFRSIGPFYIVGLLCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRK5</accession>
    <name>A0A0D8XRK5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716313">
        <property type="protein sequence ID" value="KJH47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRK5"/>
    <dbReference type="STRING" id="29172.A0A0D8XRK5"/>
    <dbReference type="OrthoDB" id="9972248at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000110">
        <property type="entry name" value="Putative nudix hydrolase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="29051" checksum="DCE52221A927FD57" modified="2015-05-27" version="1">MIHKKCRIIDIPYLRCSVYRYEVPETKVRWSVPFPEYSPPDYTDPILNNRKWADPEISAGKFNWNAFDGKINRKSFMGEYALDSTSRPMNPVGRTGLRGRGVLGRWGPNHAADPLVTRYKNGKLQFVAIKRADTGEWAIPGGMVDAGEEVSQTLLREFSEETLGGKDRYEIKQLWNNGVELYKGYVDDPRNTDNAWMETVCVNFHDSTALLDNVELRAGDDAVNVRWTSVDDCEPLYASHEYFILLLKKLHGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS99</accession>
    <name>A0A0D8XS99_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716309">
        <property type="protein sequence ID" value="KJH47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS99"/>
    <dbReference type="STRING" id="29172.A0A0D8XS99"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
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                <person name="Choi Y.J."/>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="55" mass="6259" checksum="B6ED412460926103" modified="2015-05-27" version="1">MNEIHYEVKLSSNFTRQKAEHLSEFANREIVPELKKIYDAATADDVSSSTTERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XU99_DICVI</name>
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            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
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        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <ligand>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366077"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47329.1"/>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716277">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="108" mass="11141" checksum="56DBC066A7FA8EFA" modified="2015-05-27" version="1">MSLTAEPAQATLPAAGGKSTHQLTNPGDQKLIFKVKSSNNNEYRVNPVYGFVDAAGNASLDVTRLAGAPKEDKLVVQFAPAPADATDAQAAFATVQPTGDVTIQLSAT</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716300">
        <property type="protein sequence ID" value="KJH47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV10"/>
    <dbReference type="STRING" id="29172.A0A0D8XV10"/>
    <dbReference type="OrthoDB" id="5781000at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="250" mass="28322" checksum="F2D0E31158CE2F61" modified="2015-05-27" version="1">MMMTHFSTGDEETPPSPYVCLHFENSPKNNLVAQTKLPSSLIYYRARNKDVGVKILAALIEKKPNFALYYGFETSLAVEELQKGAMFILQARRIQNFLDTIVSSLGFCPDSSIHHMSYRIGQIHYHRGVNFGADNWLVFKKVTIDQVLSAQKKSTMFNGSLKEVEKVEATAYNKPAQNIRIDQSAKIFSKQATRHVTCEQSKTLDSIRHGSPGKTKNAAIGWNKLMSVIIREMKRGFLDEARRNCEEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVA1</accession>
    <name>A0A0D8XVA1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVA1"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336135" evidence="1">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="316" mass="36166" checksum="5E18829C31958354" modified="2015-05-27" version="1">MIDIFKSFLAILDFISVNCLQLQQFPKSVLAYIFAFLDCKSLLNCELTCKKWSTVIEENLHKLPKLQTDQIRILFDEAEILIHPIDEKKCPVRYSMPSLQGLERRLHHLTTQSLFIRGLISVESVPVLRLLLSLTLRPQQVYIIWSQFSPASIPMLEKFFYVNREFVVDVGLEECSPPHLFNDSLLDSLLPGLTCLRLWNNGKSGNYAISDCSIYKLANAIADGYAVETIDLTSCSLSESSLSSLILAWSSCPLSDLCISLNYCPLLNKHSLYEILALHRIFLRDAYNKDLLCEVCRRIPKRECSYTTMLREQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWE7</accession>
    <name>A0A0D8XWE7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KN716278">
        <property type="protein sequence ID" value="KJH48142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWE7"/>
    <dbReference type="STRING" id="29172.A0A0D8XWE7"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="216" mass="23990" checksum="1679C33EF459C6A6" modified="2015-05-27" version="1">MFWLFNVFASVGFVVFVNVRGRSSTIHRKFFHLTVSLIYLSGLYCDKDFVWLSGWLMICLFVIVEVLRFFKVPPWEKTLNRSLLAFKDEQDSAVLLTPIFLLLGVFLPLFLSPSDTSPHLYHLAGVAAVGVGDSVAAIVGSKWGRTRWPGKKKTVEGSTAMALAVLMFLLLARPFCSSPRPSCTRIAVVSFVLSAVEALTTNIDNIILPTIGYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWG1</accession>
    <name>A0A0D8XWG1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWG1"/>
    <dbReference type="STRING" id="29172.A0A0D8XWG1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="262"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="349"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="597" mass="67828" checksum="0DA011F63FE2A212" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXN2</accession>
    <name>A0A0D8XXN2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_05279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN716262">
        <property type="protein sequence ID" value="KJH48592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXN2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXN2"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH48592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="43857" checksum="5C13DC8DF08EE298" modified="2015-05-27" version="1">MCRFLTETLGYGACRSVNEFQKLYRIGEGTYGIVYCARDSKSGQVVALKKVRVDSKMSAQVGISDSALREITLLKRFRHENIVELKEVAVSRDPQGMFLVMEYCEQVSVLLRHILCRFVNIYCYCNLFFFSFLYMGLDYVVRYLVSLTVTEVFCLVSETSVLKSLLDLAKLLDEMLHPFTEPQVKCLMQQLFRALDYMHSHYVLHRDLKVSNLLLTSHGILKVADFGLARVFGEPDMNMTPRVITLWYAIDKIINLLGTPTTKIWAELDTLPLLENFTLKTQPFNNVKKLRVVSEDCIAERNFAGYIKVIELALNVVFESASSSAVDLLNALFMYDPKKRISAADALIHPFFTERPLPCDPVLIPSLPPNYCKKRKRDDIPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY66</accession>
    <name>A0A0D8XY66_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ligand-binding domain of nuclear hormone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716257">
        <property type="protein sequence ID" value="KJH48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY66"/>
    <dbReference type="STRING" id="29172.A0A0D8XY66"/>
    <dbReference type="OrthoDB" id="5799552at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06157">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF5">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="27238" checksum="1145B1F7C6354C90" modified="2015-05-27" version="1">MLCRTLEEILISDCDFHLRGVATPDDYTRLFQVQMVLMFEWAEKLPEFDLLEPQNKVKLLHAFALRYLLLDNVFHTMELGYEDRIVLVNNNYIRPFEPPIYNGQFLERRTELMMYGPETKALLDDLVIPMKRMGLKVGEMMTLRMIMFWNPGNVGLTTSGIDIARTASNNAVKELHRYFEGEGVTDVENRVGNLLLLLPSFTKHVRCLYELVKLIPSFGKMNECDSFMDVLLSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY68</accession>
    <name>A0A0D8XY68_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716228">
        <property type="protein sequence ID" value="KJH49613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY68"/>
    <dbReference type="STRING" id="29172.A0A0D8XY68"/>
    <dbReference type="OrthoDB" id="6284251at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037689">
        <property type="entry name" value="BAG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334:SF6">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="28430" checksum="BC781DF6937E37FE" modified="2015-05-27" version="1">MAARIIPITIQRSADSSNNDKPAAPIPAPPIPTPMQVPVTVPAASPSPSPPSEAGTNTITSTNSNDEATVTNPRLIPMSLIRNRSIDDFNEQVVHILDEVEKRVEQLREAASMLEQEKEQILDMLNSVSLNSELLRLGQGDREDINAITNRLAARTKTVDVVVNTPRSAEQEKALTSVNSLIDGVVQKLHEDLQGGKETCRRYLNACNPDQPDGPIDQKFQAQLIECTADDQKKIRRKLAQLISQFERAERTFSPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYB1</accession>
    <name>A0A0D8XYB1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphorylase kinase</fullName>
            <ecNumber evidence="2">2.7.11.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_05060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + phosphorylase b = 2 ADP + phosphorylase a.</text>
            <dbReference type="EC" id="2.7.11.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.19" evidence="2"/>
    <dbReference type="EMBL" id="KN716255">
        <property type="protein sequence ID" value="KJH48807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYB1"/>
    <dbReference type="STRING" id="29172.A0A0D8XYB1"/>
    <dbReference type="OrthoDB" id="419455at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004689">
        <property type="term" value="F:phosphorylase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002291">
        <property type="entry name" value="Phosph_kin_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01049">
        <property type="entry name" value="PHOSPHBKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH48807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="280" mass="33340" checksum="E3D412E243D6AB1F" modified="2015-05-27" version="1">MTIGVDSDYEDHDDEAGRSTSPLLQEHSFYSIYDAKEARRLMRQLFDGVAFMHSRHIVHRDLKLENILCIDEERIVISDFGFATYLKEGELLRELCGTPGYLSPEMLRCQMYEDAPGYSYTVDEWALGVIMYTLLAGYAPFYHRKQLFMMRMIQEGKYEFRAEPWSTVTQEAKDMPWEYVRISIIGELFWSHALRAIVLVRFFCRLQRYKYLKTVTDRDSLRKRPFRDRDIRHEAESAIFSVYGHWVNRGFYYSRDMLFANKPRPKYRRGNNSTTRENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ90</accession>
    <name>A0A0D8XZ90_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ90"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ90"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="76" mass="8528" checksum="BC238CAD21D8A3ED" modified="2015-05-27" version="1">MFTKTPVAIITRRAGKHGKSITFLTPDDSAVFYDLKQCLMESPISTCPAELSNHPEAQQKPGTFVTKKRQDETLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZY2</accession>
    <name>A0A0D8XZY2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_06034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XZY2"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="169" mass="18942" checksum="57D5DA895D88ABD1" modified="2015-05-27" version="1">MVMASLENALASTGGFCVGRSYVVSHQRLSGLGYCFSASLPPLLATAASEGLRIINEEPERVRRVQRFAVTIHRGLHAAFEGTNFFLQGVEISPMKHIMYDGEEAEKKLDQLVDKLFDEDAIMITRARYLEHEEVFPIRPSARLMVQSEMTEDEIDRALISIANIVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y078</accession>
    <name>A0A0D8Y078_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="1"/>
    <dbReference type="EMBL" id="KN716215">
        <property type="protein sequence ID" value="KJH50120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y078"/>
    <dbReference type="STRING" id="29172.A0A0D8Y078"/>
    <dbReference type="OrthoDB" id="5865024at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="19917" checksum="8FB6709A274BCAC5" modified="2015-05-27" version="1">MYNSKSIFSMTVDYFVRDGLWFLCNSLQNAVPALQSAILTPNIVEFSRLCESALGVHGVLTIQDRNQLQKLACRLSSHLGTSLFLKGQVDIITTPDGNVIIGDEDGCPRRCGGQGDITSGTIAVFLLWASRVISGNEGKLAAGLASSQLVRRCAKLAFSSKGRSMIATDIINNIPSVLIKIDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0B6</accession>
    <name>A0A0D8Y0B6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium binding EGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716210">
        <property type="protein sequence ID" value="KJH50298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0B6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0B6"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="93" mass="10405" checksum="FE224D3801D46F4B" modified="2015-05-27" version="1">MESGKDGTMKEKVTDGLQAFIAGGTSQTDGLQQIQLCENDEKRLRIEAIKNEIRSETISWTNPERPSEPFQYHGSITITDVTVNGQTCQFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y192</accession>
    <name>A0A0D8Y192_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNase3 domain protein</fullName>
        </submittedName>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1274" mass="144240" checksum="5A8A7C3487502950" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1F2</accession>
    <name>A0A0D8Y1F2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Laminin EGF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1F2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1F2"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="Laminin subunit alpha 1"/>
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    </dbReference>
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        <property type="entry name" value="Laminin subunit alpha-2"/>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
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        <property type="entry name" value="Laminin_N"/>
    </dbReference>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="488" mass="55165" checksum="7E84D29DCB00268F" modified="2015-05-27" version="1">MGNTPRPGTWVLEKSLDGVNYEPWQYYAISDAECMRQFGIPATAGVPRFERDDEVHCTSEYSKITPLEGGEIHTSLINGRPGVEKPSVELQVYGSNNYALNSNRLFPKIYRCVDLQKFTRARFVRLRLISPRTLNADLMIINQQTHRIDKSVTMRYFYSISDISIGGQCICYGHAESCPSDPVTGQFKCECRHNTCGESCNRCCPLFNQLPWKPGLNSHPNACQQCQCFNHADSCVYDEELDNNKWSITPEGVYEGGGRCVDCKHNTEGFNCERCKDGFYRPSGLSHYREDACRACDCDLTGSISDVCIRDDQSALSGQHPGDCVCKPGFGGRRCERCAPGYRNYPRCEPCPCNQAGSVNFDTCEEENCQCKTNVEGLYCDRCREGTIHLNANNPLGCQTCFCFGLTDKCKEIPWSTAAITNNVGWNLTDLSGERDIRPEIENREVLMFNANQNKDNSLFYWKAPDTFTGNMVRTLTYQPYFLNMQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1I9</accession>
    <name>A0A0D8Y1I9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_03321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716203">
        <property type="protein sequence ID" value="KJH50555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y1I9"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF46">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
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            <end position="218"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH50555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="265" mass="29855" checksum="821B86AA1D2E31F2" modified="2015-05-27" version="1">MSSEAIHQKSGGTGTKPKVATPQVVAKIEQYKRDNPTIFAWEIRERLINEAVCSTPPSVSSINRILRTRAAERAAEELTMILNAQHLASQQRLSPHIPSIAIPSNSFPFTFHQAIWPGVLLNPTSFPSMPLPLVSTYSTIMPNSPTETVSMSEDDGNIRRCGRSSFSQEQLEMLESLFLKDPYPSAAQRMELVKSTQLPEARIQVWFSNRRAKWRRTHQESSGSSIERDDTEQTVLLKKNSSDIVLTEQLQRLFEHLKVAEPTTI</sequence>
</entry>
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12063" checksum="1855DA0E0F6974E9" modified="2015-05-27" version="1">MADQIKLRRRQKREKTISIEGANSSSNSTPVCLKCTQQAIGYQHLMSVLDPSNTSETVFNLSAILQACPHKTTSQNFIDCSNNLLSSSLSSFIMSYHSPIVSDVRHDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y201</accession>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="156"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="203" mass="23460" checksum="C60DDE019DC8AA2B" modified="2015-05-27" version="1">MSHGFCRKFSSKNRLHCFCVVIRITNNRLKSYSRYAVITLIYMIILHSTTCSLLRRLKRRKKIEVESPLPPQQSSSAKVQDPPMPCTSSLSQMDTMLNRTQDSSRRIISIRPSTKSRMPTLEKYPTMSVTSMQEKENCDDYLNALGEKVPSGRNTVEETQSTVSSLAENKKQCKKRRKKAKMERSNTMDSIPVCQFPNFFTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR45168:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="121" mass="13709" checksum="C95C1D387EFA801E" modified="2015-05-27" version="1">MLWVLFQDIFFDSASAFPSDSFIFNKQKFPSSRVHIFYDDDDKEKKKDCHFSTVIRFSSPSEPGKNAIIRKTSTTTKIVDGKKVVTKRTENDGEEVVEILEDGELKCRTVNPTVVVDAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2D4</accession>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716213">
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="14842" checksum="8C66F426444E7DC8" modified="2015-05-27" version="1">MSNFNERLTPNAALFWSVLVEIGMKVDEPVNESKIIESTINDLIKHGIIYPTNSIESKWIHVLPHGYPIPTLKRDDELRKAHNQLEKKRIFSRGRFGSWRYEVANQDHSFTMGMEVVDRIVFGSEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Z6</accession>
    <name>A0A0D8Y3Z6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase, AAA family</fullName>
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    <gene>
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    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Z6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Z6"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19512">
        <property type="entry name" value="RecA-like_ATAD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001717">
        <property type="entry name" value="ATPase family AAA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="364"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="634" mass="71993" checksum="9DCD939F35954F4C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y413</accession>
    <name>A0A0D8Y413_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6381867at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG08587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970:SF1">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="738" mass="82874" checksum="8F9E6758AE507E6B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y462</accession>
    <name>A0A0D8Y462_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_02835</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH50977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y462"/>
    <dbReference type="STRING" id="29172.A0A0D8Y462"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000878">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000019">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="245"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="447"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="15">
        <location>
            <begin position="794"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="925"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH50977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="992" mass="111549" checksum="28B3215214A5588D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y476</accession>
    <name>A0A0D8Y476_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716237">
        <property type="protein sequence ID" value="KJH49366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y476"/>
    <dbReference type="OrthoDB" id="9872501at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019326">
        <property type="entry name" value="NDNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619">
        <property type="entry name" value="NEURON-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619:SF3">
        <property type="entry name" value="PROTEIN NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="24821" checksum="DECED4609B229AB7" modified="2015-05-27" version="1">MAFFKQNLTKGIYLMVLTSSTSSSARLFLSHSQDEMDAFYPPLPHDTRLAHAISKDDSSDSNQVLITWKVVERVRLAEANRYRFCAIASRRVPDWAICGELNEGLESIHCVPQTNNSMVIHKLRSGRHYFITVFVRDSLHGSTSSYETLEVNLRRAVDSFSMVPKKIEIHTSESMYETNLLHDGVLETGQLSSRKGSSLDYQFIVPSNTTRSNKFHTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4F6</accession>
    <name>A0A0D8Y4F6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4F6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4F6"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
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    </evidence>
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</entry>
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    <accession>A0A0D8Y4U9</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH51197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9857" checksum="0C14D932D68BCE9B" modified="2015-05-27" version="1">MDRSTQASGDRLIDPVTKANPFLRLRIELAHFPHLQVIKWESSTDLVRVDELVSLTVNNKIEANGRQRLELLTPTTMKLTLCEKDE</sequence>
</entry>
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    <accession>A0A0D8Y4V7</accession>
    <name>A0A0D8Y4V7_DICVI</name>
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        <submittedName>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Preprotein translocase SecY subunit"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="487" mass="53620" checksum="EF346929F6699E44" modified="2015-05-27" version="1">MGIKFLEFVKPFCGFVPEVSKPERKIQFREKMLWTAITLFVFLVCCQIPLFGIMSTDSADPFYWLRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMVITVGQAIVYVMSGLYGDPSEIGAGICLLIVVQLVIAGLIVLLLDELLQASLRTFISESILNKGYGLGSGISLFIATNICETIVWKAFSPATMNTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRNNLPNLMNLMATFLVFGVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLAAKFGGNFLVNLLGTWSDASGSYRSYPTGGICYYLSPPDTLSHILEDPIHCIIYVVFMLGSCAFFSKTWIDVSGSSAKDVAKQLKEQQMVMRGHREKSMIHELNRYIPTAAAFGGLCIGALSVTADFMGAIGSGTGILLAVTIIYQYFEIFVKEQQEMGGMAAMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5D5</accession>
    <name>A0A0D8Y5D5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prenyltransferase and squalene oxidase repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5D5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5D5"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="541"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="821" mass="92108" checksum="FE959CC0ED67EE64" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5R8</accession>
    <name>A0A0D8Y5R8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5R8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5R8"/>
    <dbReference type="OrthoDB" id="5872581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24499" checksum="7EBB45D34DA6E7FF" modified="2015-05-27" version="1">MQLTPAGYATLTHQLMTWGIPLVMILEGGYFIESIAADFEWIVKTMLGDAIPRTELKPLKSVLVPVINRVHNFFGKTYPSLAMIGAIKEKLISRQNKEDEADEYEGTRDFQLPYPTRGVYSEREEQIVLKFVEELRKIMSNYGKQEPYKDVHYANSEATLPFTFENYEDHITLMVSGEAKGAVHLLTACAWLRRPTEPEQKTNIIRRNWGAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6L4</accession>
    <name>A0A0D8Y6L4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">N-acetyltransferase ESCO zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6L4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6L4"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="10">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="11">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39642" checksum="F2A7C56D1192865B" modified="2015-05-27" version="1">MEKQSRVTDFFAPSSDRKLKSVCAKTALFDVELKPLVRKKVRLSGGGSTDGQTILDAGQKNIGGVYCKQCDMMYSRDNATDLKMHEKHHNRYVNIKEVQVSSSMMNSWLRNQCHYQCQHGYVFRILPDSQSSLKSKVQQVIKDFVDTSVGFCVDLSIWGWDKRRTVWASLFNQKSMSLPMPTWLRISDSSGFAILLEIKKCSKSSSLADLKDFVDTSVGFCVDLSIWGWDKRRTVWASLFNQGSSYYIAGVVITEPLMSAQCSSTGKLIAGGDPLIGVNRIWTHPVFRKRGIASEILDIIRKWYFTGITVLRHRVAFSDPSDDGRRFAEKYIRRHANTENSLLVYTVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6N1</accession>
    <name>A0A0D8Y6N1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6N1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6N1"/>
    <dbReference type="OrthoDB" id="419138at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Meckelin"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="198" mass="23001" checksum="DE9617270FA42D52" modified="2015-05-27" version="1">MAVLSPLSILWAAVKAYSWGRRSGKATLLDTTTLLQFLLYVSSVLADVFFVVITAMSCWITFAYKLQTYPFYSILNDDQEWTMMAYLIVTLFLKFISLIHTTIHMILQEIFFIDWERSQIIEDNQQMQPISRDVQKDRKELPVVVWRKYLVANEWAELTCVRATSVSFQLLVVLLVLEAFHFMKFSIVQPGFGDGTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y736</accession>
    <name>A0A0D8Y736_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y736"/>
    <dbReference type="STRING" id="29172.A0A0D8Y736"/>
    <dbReference type="OrthoDB" id="5840777at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23318" checksum="1625A92D2BA021AD" modified="2015-05-27" version="1">MRQAIGFSRVIWYDSVTVTGKLNWQNMLNTHNRGWFECCDGIYLNYNWTDEMLLRSADSGTLNKIFVGIDCFARGCVGGWDCYRSFAKANLMRMSIALFAPGWICEKFPNENPIEHGLRFWKKLALYTPARPILTLPVSTNFCTGFTFDNQGVVSHLTKITHIGCIPHIKRFSVNSMSVQPHFVGSLLGPTPTISGGLLLPKCSCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7T0</accession>
    <name>A0A0D8Y7T0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDHD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7T0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7T0"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="280" mass="32241" checksum="A6A124969F52254D" modified="2015-05-27" version="1">MERCFPDDNSRPMFLPVEWRSALKLDDGVTDVITLPKMSSMRNALNSTAMDIMYYQSPLYRKEIVGGVVHQLNRVYSLFIENNPNFTGPVSIFAHSLGSDTHLEECTDPTNISVLKAFQEARDQLYEKIDGGINKMLQHNDEQLLFKVKYLFAVGSPLAVFLVMRGATYVDLLPSKMNVERLFNIFHPYDPVAYRLEPLFSPEYRYIRPIKLFTSNDLRARNSYDDHPLEVHKSYLKKIKNENKSKKSKIGDTRSGGDEDMDEEDECDSDYDAKSGFLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y883</accession>
    <name>A0A0D8Y883_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y883"/>
    <dbReference type="STRING" id="29172.A0A0D8Y883"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000698">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
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        <source>
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</entry>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
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    <sequence length="236" mass="27224" checksum="531CE871A4AC69B6" modified="2015-05-27" version="1">MTFNIWLSGASVNDGLRKIAKHIALVNPDIVALQEVENVDVVDNLTALLGHKWKGIYHLYSTTPDVGILTKHEVLYFVNFWSVHLDYRSYGPYAANNKLVVSIDQIMAGEHPLNSEGRAQNMEEIKYNSKMTAWRKKSKIVPLIVAGDFNCPSHLDWTSKTQRKHGGWTVQWPATVMMQEMDFFDSFRELHPDIEAEPGYTWSTVNKFNAEWDYTIPEPQDRIDFIFYQDKGRKAL</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH39773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="166" mass="18131" checksum="FE6E52D9991FF112" modified="2015-05-27" version="1" fragment="single">QYAPTAVNCQNKLSDDNCKKFYNTSVAIKTSAERPEACWKKQNGSEVDPQLVQMAVDNCPRTCGYCCLTPEYNCENKAVPRVSCSSISVSMCSDPTWRTILAEDCPKTCGLCNQNTDCTDTIPGCNRDPTICRNVALQDFVKANCKKTCGLCQSASTTSPISKLTN</sequence>
</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="167" mass="18725" checksum="08F475F8F5F6700E" modified="2015-05-27" version="1">MEGVTITLTVKLRDITPDEIIRALGNVSTRSRIVVVCLADGYDYERTFILAAKDGGYMNNEYVYIFSDTKSKGFYNPVLGGPDKPLWEDMKTPSDGRDKEALLAFEKAMIISNHMGAGASSDDFSDFKNEVIARMKDPPFSCTDECTGAVYSKVSCFNTFRERYHIK</sequence>
</entry>
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    <accession>A0A0D8X676</accession>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Tetraspanin/Peripherin"/>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="262" mass="30387" checksum="C1C0602B74D78065" modified="2015-05-27" version="1">MVAPLSNLLAALIAFRTIYGIFAINYTTLSTVNRTVSRLIALIMARLVFGAIVIITGRMLINSIDTEAVHQLVKENMAHLIRFATKEASYMEEMNRLQQSLQCCGMSTDIQLQNGNLRCFLFSKCWVLIPILIIRGTCGLLHIRWMIRIQLQLGLELYSLPWSCCNRTKNLRCEHIGVTRYLRTFDTPTDFYDIEKAIGAKQLNWNPTTFERYLDRNELAIATLYQRDCSVELFREVLYRLEAIKNLMQQTGYLLEVFKLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6G2</accession>
    <name>A0A0D8X6G2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717909">
        <property type="protein sequence ID" value="KJH40098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6G2"/>
    <dbReference type="OrthoDB" id="5794217at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="31863" checksum="B278B71BF1989FCA" modified="2015-05-27" version="1" fragment="single">MYIPDNCRKSVYDIFLECREELRKLISDGEIRSITGTHSLSSRCEYLLETVPACDLSMSLREFRNREVLANNNRENLTKYEVFWDELFKYIILIFVMMEEIETREVLKLICHLRKLPTAVTFDVNFPISPPSSCFVMYSKQEQIIQNEITLEEIKNRWDAMLPKHRIPLFEQYKRELTNFIENLEHFLVECSQLNPQQKAHVEIIIMRTKSAIHEVNNIMGKLEMTEVPQVTNAEEYFRKNVWSHYSDIVDEKERERAIQEDFNKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X784</accession>
    <name>A0A0D8X784_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717253">
        <property type="protein sequence ID" value="KJH40400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X784"/>
    <dbReference type="STRING" id="29172.A0A0D8X784"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF502">
        <property type="entry name" value="TETRASPANIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="372" mass="41718" checksum="804470ED2CDD1A3B" modified="2015-05-27" version="1">MFQLCGIGILALGVYLFIKDFGEFKLLDIFLNPAILLGVIGSCVSIVSLIGSLGALRDNIFLLKAFAICVFLCYLVIVVATFGLFVLFYSDTTDGLSAHSVLVYAIKNYHTNRNLAEIVDSLQENLECCGVSSVAQGYRDWNLSYQFNCTTANPQPERCGVPFSCCRKSVISEAAGLSNPLLPAMRSLECWQNTLKKRPQDLEHDIYTRGCLQPLRTVFESHAIHIGLAVAVIVIPVCVLVCLTNVLARQIDHQRLLLEREARRHQKRIKRERYRHQIDTEAMNRLEDGKLSDHEISGLKNVAVSKPLERSSLTSLSIEQPQKCRTNQESCNSDAKKTRNQRRRRSGTSSSNPRVQPFVQQPTDLLKSSKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7V2</accession>
    <name>A0A0D8X7V2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Core histone H2A/H2B/H3/H4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717077">
        <property type="protein sequence ID" value="KJH40628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7V2"/>
    <dbReference type="STRING" id="29172.A0A0D8X7V2"/>
    <dbReference type="OrthoDB" id="5855123at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="96" mass="10839" checksum="934DD791759AD731" modified="2015-05-27" version="1">MPPKPSAKGAKKAAKSQKVSRTGDKKKKHRRKESYSVYIYRVLKQVHPNTGVSSKAMSVMNSFVNDVFEQIAAEASIHFQMYFLEMSCGDYSSMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X832</accession>
    <name>A0A0D8X832_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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        <source>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KJH41012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="15836" checksum="43BC575A2128A1BF" modified="2015-05-27" version="1">MLTGQHIGNNIIRGCFASVFKYGTTPRAQNSRILVKSTIRYNTKYAVLPYYFIIAKDTSCSRMPAHRLLPPHMAARSSNRSVDLCWCVGQLCNDYPSVPMNSVSWGSECSGEGVTSTRDAARNCGPSCSGPPNTPPGTGCCWKGPI</sequence>
</entry>
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    <accession>A0A0D8XBD1</accession>
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        <name evidence="1" type="ORF">DICVIV_12103</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20468" checksum="0E137069178D70B2" modified="2015-05-27" version="1">MIGIVDVDESKFDRYFKNSCPLSAMFSDINRVIRAFKQAPFPTGWRYCIAHTVFSARVKAYVIITLMIAERRARGEVPPKRVKVIRSIPIEKKASDVPKKENDEVYLSREMYNASNRCACCGDTIKNIGIAWDLYYNSVQNFVNLVKTRTTSKYGYRMSSSCFIRKTRLHAFHEMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBG5</accession>
    <name>A0A0D8XBG5_DICVI</name>
    <protein>
        <recommendedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
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            <position position="1"/>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="8827" checksum="12BE7F3098A153B3" modified="2015-05-27" version="1" fragment="single">YTFDHQVSLKPKTFYRVRVAATNDIAEGPVSETKEFETAHPDLDEWVVMLSGLRNFSNFILSIATVTSNGEIPVDSIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="17" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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        <location>
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            <end position="213"/>
        </location>
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        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="213" mass="23963" checksum="3BF9E55A9FCCB679" modified="2015-05-27" version="1">MIISFIAFEMLMVISAKPYGENSVISQSYPYKSALNSRQAFPPAVYLPTLLSSDSLFTNPLGYSNGQLNNVINDAYGNRPQSSAKYRPYGASGLYNPLYDLNMPLSNSFYSAPYRRHRRRSYRKSDPMEDNNSDSSSDVTWESIETLKPQTRRSIAKQMTKAAVVTDDSITTIDNTRSSRTTPFTITTTNNTTIMNETSRSEFGTTVYLRSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XBZ6_DICVI</name>
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            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718769">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="56"/>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="91" mass="10186" checksum="5C5890DE4923C71E" modified="2015-05-27" version="1" fragment="single">NYALIATEHKNVGLLNIEKYEDMYPNALSGGQQQLVTIARVMAQSTDVVLLDEPFSNLDMLSKSKNTPVLMVTHDLQEALNVADFIYVMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="17494" checksum="3F72328AC6EC0A83" modified="2015-05-27" version="1">MLILHLFASFPLRLSVVYFTSVQHRKYFNALRCVAVLVILIWITSLCTKHSKSIKINPTSSVESRSLAGKPKAPVVDGATKTQQLPASIVTAPTQSVTHSGAGNTAATTLAPALSNTQSSANKTVKPEEQKFLPYPEVKEPTPSARRRRAEELAKDKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEB0</accession>
    <name>A0A0D8XEB0_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_13292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEB0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEB0"/>
    <dbReference type="OrthoDB" id="5816235at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="285" mass="32731" checksum="82B82925BA872A8E" modified="2015-05-27" version="1">MDIEPSTLPANFTTIFERTSPLRFRHRLDYHSFSSMLINSLPENGLRALTLDSRRVSMLKIAKFVDTIKEAVDEICEELRTRENLSKAEVQAEKDLSSEVQQLISSRYVETVMKLVEACAQAIDVPLKIISDRFHLLLFGWDSFLLQGGVLRVRLQLSPGRSHPGIIDVTTNWLDQIDTVLSRAQATLSTRTSAFAVSLAQEKNIMSKVWHKMAAQTSSSFIDQSFIYCSECKLYFHNEDTDFMHNRIFHQKSRECEECYDMFHTLLGLDLHMVGYHKRSFVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XED2</accession>
    <name>A0A0D8XED2_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_11997</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716722">
        <property type="protein sequence ID" value="KJH42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XED2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="69" mass="7802" checksum="1765807719D7C5E5" modified="2015-05-27" version="1">MKQLRFNGHRLNLLCFPICGCFSGNINSHLIPKQVRSNDPESQSISQYEDDFTKSDTRLICVSVKNGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEG8</accession>
    <name>A0A0D8XEG8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717007">
        <property type="protein sequence ID" value="KJH40811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEG8"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF16">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CH"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="400" mass="44936" checksum="0B001233D691E81E" modified="2015-05-27" version="1">MDRYSMSNIYKLDQSAVIMPVFENQYFALFCAFLCERDGFSQPGWLKIDPLKIHDLSRDLSDGIVLIRLIESLQGRKYNGKIYENDPTETQKLFNVQIALDALKEDGIKTVNIGSNDVVEGNRRSILGLIWCLIQRYQISSRCKIPPKKLVLTWLQSAIPEVKLTNLRTNWNDGRALSALLEYCHPGLCPEWKDLDSKQGLKNCERAIELASRYLGIPSIISATNLNSPNLDELSCITYLSYFMMKGSCGYRAALRRVQLILPHVVIEDFESSWSDGYLLSLLVEAVGGPVIDFDHMKFGRFDDYVKNIKIALVAASNIGVESLVKAEDIADPQGDHLGIMVLATVLCSVGPQPHFHTAECFTNQQVNLDFEFANGGEIDVDDLTINGLSSIFTNDVIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEN2</accession>
    <name>A0A0D8XEN2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B3/B4 tRNA-binding domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716705">
        <property type="protein sequence ID" value="KJH42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEN2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="24803" checksum="ECD60F9EDE1A3AB4" modified="2015-05-27" version="1">MLLSNHIQPGNLVENICRLVTIFTGVLLFLCDLDKIHGDILIKTAENKSVTVDDKGRKYSIDKDDLILTDGTNKIIALEGICINQEVKVDENSKSIHAIFGNYDTARLAKTIDRLNIDDSVSAKGINRVQCNDVIDKLKLLVDEIRNNENKLMIDKVVALDLSYKKYGTRIKVSYDDIVNFIGFRITKREIKKNLISLDFKVRPWAAFSRQYRTDIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEZ4</accession>
    <name>A0A0D8XEZ4_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Patched family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716583">
        <property type="protein sequence ID" value="KJH43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEZ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XEZ4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="270"/>
        </location>
    </feature>
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        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48853" checksum="860C1B74522F7445" modified="2015-05-27" version="1">MIQWMNKENECCKVYTYDKNVFCPSSRKDCTVPVPHLVNNDDDRLRRALFAAYNCTACDQNQRNGRPTEERFYKHLKDFMNDVPNANCIVGGRAAFKDAIHLNPRGHVQASHFMTYHTPLRTSREFTLAMEGARKVARKIEQSFEGKVHVFPYRYADIFYSPVKEMFKNSVTLTDLSVFYVFYEQYSTIIYDASTQIILSLAVVYAVTCVLLGLDPVSAFITVLIITCILVNMLGLMVLWNIDLNAISVANLVMSLGISVEFIVHIIRIFTHSVRRTRIERAEEALAHMGSTVFSGITLTMLGGTLVLAFAHSQIFKVFYFRMFLGVVIIGALHGLIFLPVVLSFIGSPINRRLLQDTIRDESQNQHEQRTERRAKLSCIRSKNMALALPSGARLADKLKEKTRDHSSVNFIETSSVVSEDPPLCRSLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF61</accession>
    <name>A0A0D8XF61_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA binding repeat protein, Pumilio-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716911">
        <property type="protein sequence ID" value="KJH41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF61"/>
    <dbReference type="STRING" id="29172.A0A0D8XF61"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
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            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
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            <end position="256"/>
        </location>
    </feature>
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        <location>
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            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="402" mass="46577" checksum="6981F45E7F61C569" modified="2015-05-27" version="1">MKKLYGSHRFCFRITVNRSHILEDFRNNRAPPLQIADILCHVVEFAKDQHGSRFIQQKLERASDKEKQLLFEEVLAKAHVLMVDVFGNYVIQKFFEFGTPEQRAALGRSLKGNVMNLALQMYGCRVIQKAMETIDESLQLEILREMEGHILKCVKDQNGNHVVQKVIEKVKPERLQFIINTFTKNGSDTITQLSTHPYGCRVIQRVLEYCSEEQKRPVLEALHTSMNTLIVDQYGNYVVQHVLEHGTNQDRDRIVQEVRLFDLFLALKVAGNVLRYAQHKFASNVIEKCLICAGGHHKTLLIDEVCGALNDTQPPILLMMKDQYANYVVQKMLDIADPVYRRKMMYAIKPHIPVLRKYSYGKHIITKLEKYFQKQQCTHAQHQYSQYDLPEMEVTNVNSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFH0</accession>
    <name>A0A0D8XFH0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716661">
        <property type="protein sequence ID" value="KJH42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFH0"/>
    <dbReference type="OrthoDB" id="9894375at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="394" mass="45594" checksum="263A2D16AA6B005E" modified="2015-05-27" version="1">MANQTVLIENMKLLPPFNIYFTSLDRIESWEDTAHCFGILYVIVGCLAINLNLTFLYSLLVKCRRKSFSSTFYIMIIDFTVIDTIKGISSILFAIKFLKSNLNLNDSLLFIRIDQFSVFLLRFANLATILNLLTITLNEYVFICYPLRYSTLITRRRIVVVIICIWVISLMATLAKILVGLQNRRIWIDDVCTLEAMSLSSCVYRFQTSGSAQFVYHLVLMVFCLTCLIVTVYSYSILFRVVSNQIRAEIELHAELEHLNEQAVEGKQQQRRIDNKQLLRRYKHVVVIGIVICVYTVYMIAYATIQVLLLVDISETSDGSHHFRSLYLKYICYFFISLHSLLQPLCYLRIREFRMVVKRTLCSKSDNKQAIGNDICSASINPKNFLNERDSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG62</accession>
    <name>A0A0D8XG62_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A49-like RNA polymerase I associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716543">
        <property type="protein sequence ID" value="KJH43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG62"/>
    <dbReference type="STRING" id="29172.A0A0D8XG62"/>
    <dbReference type="OrthoDB" id="5851809at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="428" mass="48424" checksum="D8E192C009D8EA24" modified="2015-05-27" version="1">MPKSEVDKLRHEREKIKRKSLVGRSSHDIVASFSHHRIVDVEKLHFQEHHATYGSWQNEKIFTVRTEACENVVEIGKEVSNLDEGYDYAIAIVNRETGEMTFREVRFYAFEAVHSLHIPELIGKKKRSSPDYNACHDIKAEDFARKRVDLTTHFGSSKKIKIQEASIRRQINDETLDAMRKTAFASTTVLAEVEDIKKEQISMVDNARSSVLPHPHSAELPHNIYPISIFLSDDEIRSLSDCALEYLSSSKKQLSESGFPEPVLKMLTDSGRKDPSLAVPFTLLGCMTFLSSLFSSKSVLKRQFNKTPFPEPFVQKVMGDFINAQIDRGANGKMSERLSVSSHEKDRLVAHLLALALTLSSDCSLPITQWQIALKKSNRFVEKILVGLGCDIIQCNVEEAARTESLRAARLLRPPSKECGAKKTRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG74</accession>
    <name>A0A0D8XG74_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_12652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716838">
        <property type="protein sequence ID" value="KJH41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG74"/>
    <dbReference type="STRING" id="29172.A0A0D8XG74"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335625" description="Receptor ligand binding region domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="11">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="16869" checksum="C786A348E4DB2A2A" modified="2015-05-27" version="1">MNVLSWLVFVGTLRPISADDPVPLYIGGTFPMEAGSGGWAGGQDLLVMLQRYICILLFFLFLRFSFIKACLPAVQMALEDVNSRPDILPGYVLHMNTSNSKCQPGLATQQLYDLLYTPPIKLMLLAGCSPVTTVIAESAPVWKLVVVRLLCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGD2</accession>
    <name>A0A0D8XGD2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_11237</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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        </source>
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        <source>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI67</accession>
    <name>A0A0D8XI67_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716480">
        <property type="protein sequence ID" value="KJH44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI67"/>
    <dbReference type="STRING" id="29172.A0A0D8XI67"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="472"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="578" mass="64555" checksum="F31174FFD0D9B28A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI94</accession>
    <name>A0A0D8XI94_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716553">
        <property type="protein sequence ID" value="KJH43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI94"/>
    <dbReference type="OrthoDB" id="5808628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="17884" checksum="9C9529128126D609" modified="2015-05-27" version="1">MAAARLEEVENRQRTLLANTDNRFSEGIDPVLSLRHSIAAIDARLSSNKATEEEKTDLEKLAKDLRIFLTGLPDDGSNSLLTNTSTGPPTELRVNFDRDVTANVNVETSSGISGTTISTNETSSSSFTTSSCPPAANSTPLADSSNKSKDSQESESINAKETSSTMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XII9</accession>
    <name>A0A0D8XII9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716705">
        <property type="protein sequence ID" value="KJH42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XII9"/>
    <dbReference type="STRING" id="29172.A0A0D8XII9"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF42">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="192" mass="20959" checksum="CD5E6F27E722634F" modified="2015-05-27" version="1">MIVAAQDVNCFSSGAYTGTVSWSQLKDIKINYAIVGHSERRMYYNENDDLVNQKVKSLLENNMVPILCIGERLEEFNAQKINEVCEFQLKNALKNVPVELLSRLIVAYEPIWAIGTGKTSTPENAQKVINHIREVLSTIAGSENAKKVAILYGGSVKPGNIKAIISQGDINGALVGSASLVANNYISLLESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIU7</accession>
    <name>A0A0D8XIU7_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Noc2p family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_10288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="692" mass="79746" checksum="7520BC9C31510BE9" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8XJ03</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716532">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ68</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716521">
        <property type="protein sequence ID" value="KJH43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ68"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16003" checksum="60849208406DDB9B" modified="2015-05-27" version="1">MKSMSDVKSLAAYSSITHITSIQSRRICLNNGPQCRGSGLVRFYSIQSIVMNNRYQDSGSFTATLEEDKRGPQILILDYPRRSQPKMLTAAEQADRPTGSSGLITTGDGKVVIQFRFESRHNIFVQRLRWISGSAMSTIAISTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJH7</accession>
    <name>A0A0D8XJH7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJH7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14587" checksum="F44146C7157EE5AF" modified="2015-05-27" version="1">MMASIPIHSLTFFSHIKVQWLRGYSQDIYCATMAGVKHFTATKFVSIKIDIVHCVMSQAEQLKALSPFRAAGRIRAAGEKMRTDPRHIGTINLNYSQLFVHANAANIVTQNRSKVEEIPRICEGKNHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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        <name evidence="10" type="ORF">DICVIV_08725</name>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716419">
        <property type="protein sequence ID" value="KJH45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XL41"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative rhomboid family"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
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        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="711"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="741"/>
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        <location>
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            <end position="797"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="820"/>
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        <location>
            <begin position="841"/>
            <end position="862"/>
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        <location>
            <begin position="681"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="122"/>
            <end position="143"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="903" mass="102719" checksum="997D76CC8377E368" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL67</accession>
    <name>A0A0D8XL67_DICVI</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44507.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23395" checksum="CEB269D837A6A772" modified="2015-05-27" version="1">MCSEQAMIVMGPMLLEKLKRLQQPNAHFLQYMQACCSECQKINPGGWGASLPGAIFDPPLVQKPNPNTDRGRSQLNILVDNVVRDLPSFDKHTHLLQSYIEKHPEEAGKLEEYLQELYRAARLKTVGSVTEQQAVSAAQNLFTLRSRFETMRHAGQCPLPISSTIEYSPTGSVLQAKDINAESFTRLASSPWSYNVVFYFTWICAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLH6</accession>
    <name>A0A0D8XLH6_DICVI</name>
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        <submittedName>
            <fullName evidence="2">DB module</fullName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_09364</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
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    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="338" mass="37807" checksum="3E6434D01E716E5B" modified="2015-05-27" version="1">MTQFRSFPQQKVQPQIQTQAALPQRYTPVQPPFRHSQQPHLPASHKVIISKSTHNKVPVQQQVEQRLDIHQRIRVPPPPGRFVPHLADIYGHPMPDRPYLPPKFFINSSIESLPDGPYEAEEKNENGKHRSYIEDTAKTSPINKIGRISKPKIIKPSPEAQLRVSGQWTTSDDGSFVCCSIVIGREIREIPKSEIRRPSHRSRPALQQNSTTVHPVHMSKSSFFNTIPKPVVAATGSKLSKNPNVAFLNCCKAAKVAKSCERICNFDILNKKTLTGMFLGTDPCPQSYGLDLLQCAAQSEDHTTCCQDRGVHTTTAGDKCLGFCNMRPGVNFQVRGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMS6</accession>
    <name>A0A0D8XMS6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="190" mass="21440" checksum="6B7E1ED57426109D" modified="2015-05-27" version="1">MQNGELNGSEEYKDKQGGGAGLPLTKVENNDGRKVLTNGMSRVHRILSEDEINQGKTTRWTELEIHGRVRNLSNALWQVSHLSALFLNGNQLTRVPPEISQLTNLTMLDLSHNKLRSLPAELGDMISLCHLYLNHNQLRVLPYELGKLFRIQTLGLQGNPLSPEINKIYHESNGSHKLLHFLHDHLASKC</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    </organism>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="23225" checksum="57CF726F8D6C3EA8" modified="2015-05-27" version="1">MWYEPLNKFLLVRSAELDAETRFPLSPFKLINTRTDFPQLCTGIRTTDCTDKYKFDWITFGDQEQVRSVKEMTEISRFCHSKLNVATMSQLGRDSVLFAYRNKVVITNLEGCEKTKLSVFTFNFNIEYVHCMTDSILAFHPHGVQGRCLSNNTVTQDILDMSKIYRVIGNDRVITLKSHPLYSCEKYDICLLTGHEATPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XND3</accession>
    <name>A0A0D8XND3_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716419">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XND3"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9545" checksum="3D61CA784ED5461B" modified="2015-05-27" version="1">MGYPPGAFILTTNVSKAKALPFVQLAGNATKIVLAYWILKTDPSNNNILSPLIELHDLPQSKFTTVAMELVPKNEEYEPDGCQLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNU2</accession>
    <name>A0A0D8XNU2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="117"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13275" checksum="DE13A5A250C6607E" modified="2015-05-27" version="1">MIDETMNRRAWLQKYEHLISGFAGGVVSTVVCHPMDLLRIRYSGEFSVSLLLANLYYSRKAIISADEGGSFRPRYNSYIHATKSIVRVEGIRGLYQGLTPNVVGAALAWGLYMEWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP53</accession>
    <name>A0A0D8XP53_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08383</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716400">
        <property type="protein sequence ID" value="KJH45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP53"/>
    <dbReference type="STRING" id="29172.A0A0D8XP53"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000040">
        <property type="entry name" value="Calcyclin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26439" checksum="B034A420BDE5EBFA" modified="2015-05-27" version="1">MADDIALDIEELNSLLAGAKRPMIRKWIESKIETLKTKQHVSVPESPALMSLQKNKVLCTTLPTVKLTSYGWDESDKFVKVYITLQGVQNVDPSNIQHSFTKNGYDIMVSDFGGKNYVVTMKGLRDEIVPESSQIKQKVDMLLVMMKKKTEGKKWEQLTKLEYDEKQKRKPKFDDKSMEDDPQASLMNMMKQMYEEGDDEMKRTIRKAWHEGQSKKNTADISSMSGMDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQX5</accession>
    <name>A0A0D8XQX5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716321">
        <property type="protein sequence ID" value="KJH47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQX5"/>
    <dbReference type="STRING" id="29172.A0A0D8XQX5"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12640" checksum="7A2C10891027C2E9" modified="2015-05-27" version="1">MNKSYCQISVIYVSNESRIGNELYYFWAKVFIESIIFHAESEKERYVGSMLLEPRSLFLMTDEAYVNMLHGIKEVTEDYIDEHVFNGQRHLGETLIRGTRQDFYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS35</accession>
    <name>A0A0D8XS35_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716312">
        <property type="protein sequence ID" value="KJH47330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XS35"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF20">
        <property type="entry name" value="MYOSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="162"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1448"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
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    </reference>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023038"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT95</accession>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="102" mass="11533" checksum="A0F2E628031A09CE" modified="2015-05-27" version="1">MLIQSGCTDHVCRADLDTTLSSHLLLKFTKSFDSITFSSDRFSPDHFCVSRKLLECISMQGFVKNAAGEFWKKSPAAISPQLLNFRSTEARHPMWFVLLTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTQ5</accession>
    <name>A0A0D8XTQ5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytoplasmic polyadenylation element-binding protein 1</fullName>
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        <name evidence="12" type="ORF">DICVIV_06028</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with fbf-1.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="159"/>
            <end position="259"/>
        </location>
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            <begin position="431"/>
            <end position="442"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="450" mass="50471" checksum="E5DF0084089D9544" modified="2015-05-27" version="1">MHMAASMGLPLGDLHSQLAALTLQIPPYQPESTSGSARVHSRSSILDESITSQAYNPLFGAEKLFAGLARQHAVVSQNPSMFAYSCNSHSPTMIPSRYARPENALPMLLAGSGNVLFKLRSIHLSGTLENKPTLYGRKVLGAPSRSAAHFSNDVEVFARKVFVGGLPIDVTEEEIWQTFSIFGNVLVDWPRRPDGTSARDEETGRGSRSMTGYVFLVFEEENSVQYLVSECHKEDDRYYLFVSSPTMRDKPVQVRPWRLADMDFISNPHTVMDPRTTVFIGGVPRPTRAGELAECLERLYGPVCYVGIDIDPELKYPKGAARVTFVTTQAFIAAINGRFVHLHHGESQKRVEIKPYVMDEQMCDHCEGKQCSSRYAPYFCGDVDCLQYYCEVCWDRVHYRVGSRRMEHRPLVRMGDQTKVLPRPPHHGNRSSRAFNGSSQSRHYGASSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVD3</accession>
    <name>A0A0D8XVD3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:P-body"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49392" checksum="D361F7EB9EA2CA46" modified="2015-05-27" version="1">MMITSTFEFLFYGIYRISNVPAWLKSLRLHKYTSMFAELTYEQMMALNEAELERRNRLSLSNPQRCLRCAIATLRQIITTPIIPYTPSPGESSDSINGFVAISSVNDQNLPGLIFNLLDEVQRAVFVPGKQPIDIEYEYLLMLFTIFDRLCVNEAFTHMQRQRVHQWKRLARKAIRPVDVRRRRVGLPHSGKCENCHYKDFVCRENKKMGSKSNGASLDKKLSNQTQQYQMAHSAFNKHLPLSNRDWSQFARNSLSASSPSAIQHHRKQHFNSGQWNPSFYTDCNNILRTRSRQMTSLSAQVFTQNLPQYRSQRHFEASESTDAVPLLSVSSHTYEGSSRWPRAIYGNNELLIDENIAREKFNSNPLDHSIGLWESLAFPCSTLEHGSGDLTSGYCSSTSEHSSGAGSPRTSGPGQTLYDRVCRDMAVLQLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG0</accession>
    <name>A0A0D8XVG0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVG0"/>
    <dbReference type="STRING" id="29172.A0A0D8XVG0"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001462">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rab"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="25119" checksum="EF2F01EC9868C005" modified="2015-05-27" version="1">MMVQWKNVRLLFDNEICGRAFNSMNPKDFVDIKVVIVGDTAAGKTAILKRFFDETFEEEVSSTIGIDFRHVIYQLQDKTSVRLRVWDTAGQERFRHLSPSFIRDAHVILIVVDITSSNILEQIERWTSFVQGVQNNESLLIFVGNKCDLKQRSENKQIEKLIAEYNAPYIETSAKTGENIRENYRRPITKHLGVILVVGNVPDCLAVFSVLFEIYKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVR3</accession>
    <name>A0A0D8XVR3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_05199</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716259">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XVR3"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="22991" checksum="B0BD603704D100CF" modified="2015-05-27" version="1">MYKRIDDFEDFPPTCSSSDDHERVSPRHESTITPQRPLHGEHIRSRDDVIGGSLRDFSPRRKTITIGKTARNVVLSESFERMSVGIASSGLPPRAPIRNTPATASLRTHAFPPPYSNTNKHKPPPYPGRTPSGPSCSTPLPQSFVPQSSSTPKSTNGSPAKEADKQQEQVVAEGERRAFIREKEDRLDKAMSIYENVSQAELIQPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVX8</accession>
    <name>A0A0D8XVX8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05224</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716260">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5849431at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF3">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23889" checksum="30AA0DD485DBE5A7" modified="2015-05-27" version="1">MRDDYTKHGICIVCKSPSSSKFKLVLFDKEGGESQKKKAGTQAEMFFVPFTIANLGEFVPMKFHMEDRDTPLAFHYLDTLETQVAHLLDTRTHILCVYGDNWLNTVKYTITFLPISSDSVIPLEEITKVEKILLAKKAEMAKFQKEYAEAKKKFEEAVEKLKREDKDIQDKLKAREKAYDDVINRSQMLYNNHVSPSRSGKSFFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWM2</accession>
    <name>A0A0D8XWM2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_07194</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716337">
        <property type="protein sequence ID" value="KJH46741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWM2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8306" checksum="7FE619006E776E7D" modified="2015-05-27" version="1">MSSYFRSNFVSWKTGSSLSNPYTPVYGNAYDVSSFGYNPEFPSFSSFQGNPSHYQHQQLAFTVFKRYLNIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXK9</accession>
    <name>A0A0D8XXK9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716263">
        <property type="protein sequence ID" value="KJH48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXK9"/>
    <dbReference type="STRING" id="29172.A0A0D8XXK9"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="495" mass="57299" checksum="5C1FECE75BA50894" modified="2015-05-27" version="1">MKLLHIVTQRWKENYEDSCDKRNAYIATQAPLPSTFADFWEMIWQEMSNVIVVITNMIEDGRRKCDQYWPNSSGSPQTHGNYQVSLVKEMSNTYFVHRIFSLRIAKRVPPAERRVHQLHFKGWPDHGVPETVFPLLTFMHYVAEIHSTGPIVVHCSAGVGRSGSYILMDSMRRHLNNSRKLNLMGHLMHMRRQREKLVQTVEQYILCHETIRELIRHGITRIHANSFSRYVNFLNEEHLNGKTRMQMQYEDLCECHHNPPCSPPGNYITLPGYHRANEFIVVNWHHECPELWQLIWLQNCQTIVLLGEREYWTGIESVENISIQHGENFVLLQNNEDQLCVRVVTVSRAALDFDFWAEIERIQQERLVYHDAPLLIINPTLPDTILSSNGIVSPDDNAHHLLLNNVTSKSSTLSLSLAYNVLTIIVDPSPSLAYLICALTSLACQLEQQGCVDVVLLLSTYSHTKCGIWHSKFELMSHGFELITKLEVSRRRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY59</accession>
    <name>A0A0D8XY59_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716229">
        <property type="protein sequence ID" value="KJH49603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY59"/>
    <dbReference type="STRING" id="29172.A0A0D8XY59"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF352">
        <property type="entry name" value="SYNAPTOTAGMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="10331" checksum="E935308BE4E94A52" modified="2015-05-27" version="1">MYLYQGRKLLNPYVKIYLYQGRKLLSKKKTSRKYRTLDPYYNESFQFKIEPYLMEKVHIVISVWDYDKMSKNDFIGEVRIFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYY1</accession>
    <name>A0A0D8XYY1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_04774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYY1"/>
    <dbReference type="STRING" id="29172.A0A0D8XYY1"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11826">
        <property type="entry name" value="SH3_Abi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028455">
        <property type="entry name" value="ABI3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF0">
        <property type="entry name" value="ABELSON INTERACTING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH49067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="47814" checksum="1B6FF7EBE16DE9CD" modified="2015-05-27" version="1">MMLGENEGGMAGNDLRTLIESRIPEHRALLETSHTNLENVAVYCEASYLNASDRNAAFEQTKQFALQSLASVAYQINTLARDLLDMLDLQTTKISNLTDEVRNIDVVVNIHKEKLARREIGALAANRSIQKHPKIIVPVVQESVQRYKRTPIDFSILDNVGHGTPSDVPLHYHGSVVSRAASSVSGSHPYTNQYSKYERTANIGTNTLGRSSVRSGHFSMTPSEHYKTPLVLPIMDHQRYMPVVSVGEHQSVVEHGSYSTGSRNGDGSRTGPSRFRLSNRQENYGVVLQSNVIRTSIAEGTDANSEGRSESPVFPLPPPQLSTHYDYVGVTRIDDLPPPALQMLNSTHEDDPLPPPPNSQGNFFDVHADWIPRSYIEKAVALYDYDADKPDELSLRENCIVYVLRKNDDGWFEGVLDGVTGLFPGNYVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZK0</accession>
    <name>A0A0D8XZK0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_04561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="892" mass="99131" checksum="7C23BD6EC993E989" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Y7</accession>
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        </recommendedName>
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        </alternativeName>
    </protein>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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            <dbReference type="ChEBI" id="CHEBI:195366"/>
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    <comment type="catalytic activity">
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            <text>10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate</text>
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            <dbReference type="ChEBI" id="CHEBI:57452"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:59145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:18447"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.</text>
    </comment>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PurH-like"/>
    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="33994" checksum="ACF7E79CBB7958C3" modified="2015-05-27" version="1">MFMKEQIEMSYPIHIQENRKCSEKDVGCKASSHTFKHYFFQISDLRQQSKIETPAVDTKLREIRLTRQVMCTIEDHWSTAGLSWQDLILKLLYDIKLVDVVVCNLYPFRSTVAASDCTVEKAIENIDIGGVTLLRAAAKNYARVCVLCDPRDYEKTLDQVGRKWPENKSQKKTLTAGGRDGMENDFTKRSFLYFTNDSVLNITSGPTIKRGGVDIVARRLLALKKRTPAGSLLRSFALCTMDLVVIECDHRLHRNFNSSVFSKSMLFIFPNFPGNNLPTPKKMLRKQTKQVALVSLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y113</accession>
    <name>A0A0D8Y113_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716225">
        <property type="protein sequence ID" value="KJH49719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y113"/>
    <dbReference type="STRING" id="29172.A0A0D8Y113"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="205" mass="23582" checksum="974542D0345C745A" modified="2015-05-27" version="1">MEMTNVSEVSTVRCMIIGDQNCGIEMMLRKYATYSGALYDSENGHVITAFNDKKCVFTNYLSNNYVDNIHVFLLCVSIAYEDIVEETVRMVLSTITDQIRTVPFVLVGTHIEKRLVQTIDLNADWQSTSRAYRTMPLHRAESFAQRIGAVKYLECSEITGEGVEEVFEDSFEVGYQYAIEQQRNLLCRKQSRKSFSKRLFSCIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y144</accession>
    <name>A0A0D8Y144_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y144"/>
    <dbReference type="STRING" id="29172.A0A0D8Y144"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12142" checksum="40875D89D3B7C509" modified="2015-05-27" version="1">MLSILDKREVFGSFPGRYRLIDEDQLVQRLDNTRTIKAHEACVNTLRWNRGGTTEFIDLFSLLASGSDDRKVKIWNLNGDCLTSIDTGHHANVFAVEFLPAVYVISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1M2</accession>
    <name>A0A0D8Y1M2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716266">
        <property type="protein sequence ID" value="KJH48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1M2"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF354">
        <property type="entry name" value="GM14138P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="93"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="47160" checksum="8FD58520241F1FBA" modified="2015-05-27" version="1">MYIANVTLVEKQPYPYSRPEFLYFSEDEVLLSADQCVRPVLCPKYPSKMPLCAGYAEVVNAGKTSRNEDQASARIITIVQQGYEAEEAKELEHCQKTGSVSKNSAKDDDELMSPNNGCVASPLEAASRVEAAFFAIFDGHAGTGAALVAARCLHEHIKVLLHFCIWMLSWSDVTNWLLEPFKRHLSTWHDSQIAEDKQTWRISGGCAAIAVLILLGKLYIANAGDCRAVLVTGKGSRPLSSDFTPSTDRKRLQYIAYQNPELIGSRFSRLEYSRILMKKDLKTKVLYRDWFMDGWASKTVKECDLKPPMISESSRKKRLLNTIGVSRGFGDHHLFTVDDHLPIKPFLSSVPQVQVFDLRNLDSLTDKDVLIVASDGLWDVLSNEDAGLIVRSSLSATEQSEESRQEALSLLTSFKLIIATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1Q5</accession>
    <name>A0A0D8Y1Q5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y1Q5"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336139" description="Cell morphogenesis protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="3">
        <location>
            <begin position="131"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="3">
        <location>
            <begin position="548"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1716" mass="193956" checksum="BC2F4F3C07AF5489" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2U5</accession>
    <name>A0A0D8Y2U5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_03347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2U5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2U5"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="420"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26853" checksum="A50827F0A6C052D9" modified="2015-05-27" version="1">MIILKSNFSSTSSAGKLIGGFMVAIWDVGVYSHVLSSINRLVVITCPIRSRNMFSQRNNLIMIAIVWFLGFVHFLPYLKMDECYVVFFSTSYLWTFSSNTCGFILGKVLDFGTGVTVFIIVVVCDAITLWRIRHTMMQLNERRSHHGELKLFAQSCIQFSIFVVKLTNFYFISGYFAVDPVKYHWPLFFTTTFVWEFTHCIDGLIVILFQYNGMADNRKAISKSARISTMRDQ</sequence>
</entry>
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    <accession>A0A0D8Y4E2</accession>
    <name>A0A0D8Y4E2_DICVI</name>
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    <organism evidence="10 11">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4E2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4E2"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="78"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="467" mass="51059" checksum="A8AD01790FFFF83D" modified="2015-05-27" version="1">MEVDEAPIASADIIKAFVSEEEHTIRQARVAAHSHVKGLGLDPVTREALPNAGGLVGQTLARTSAGVIVDLVKVKNMAGRAVLLAGPPGTGVDLIHVLGKTAIALAMAQELGDKVPFCPIVASEVLPIFYLLCWEGRRRMLPAGLRVKEKKEVYEGEVTELTPVETANPLGGYGKTISHLIITLKTAKGSKQLKLDPSIYDSILKQKIEIGDVIYIEANSGSVKRLGRCDVYGSEFDLEADDFVPLPKGDVHKTKDLIQDVTLHDLDMANAKPQGQQGSLSSLFNQLFKPKKTEITDKLRSEINNVVNDYIDQGVAELMPGVLFIDEVHMLDIECFTYLHRALESTISPIVIFATNRGMSKVRGSGEMSPHGVPRDLLDRLLIIPTVDYTIDELKRIISIRASAEHVNLSPSCLKIVAEIAHDTSLRSVAQLLTPARLQAQASGRDTVEEEDMKEISSLFVINRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y547</accession>
    <name>A0A0D8Y547_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y547"/>
    <dbReference type="STRING" id="29172.A0A0D8Y547"/>
    <dbReference type="OrthoDB" id="5828165at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="37143" checksum="4CB7D4844C994E41" modified="2015-05-27" version="1">MFRNRLPCQFCRDSSNIVVRRKNFLGINAELFELSMDGTKWLMVDNRMMYISVYRNDMDRIRIVAISQTGKTVLDTTLSKDQKVEKISDCFVFWRDANGRTLGVNTLNSKDANLFLTHTSNSSTIPVTTMSQHNVIAQVTLIATWNGEKILKQNRIQEPTMVTLIATWNGEKILKQNRIQEPTMASLNPLSMVFHHNHGLINIDLQECFITLTDKPNILHLSYASQIYEFEFVGEAKRFLIQVLNMSSLLLARTTCIDVAVTFLNRQHQKHHEKLQQLKSQRDSSMDKEKLLLKDFAVQYRLCALSNKPLPTYEVSQQFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Z3</accession>
    <name>A0A0D8Y5Z3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5Z3"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="166" mass="18702" checksum="97F3CFC30880E777" modified="2015-05-27" version="1">METQSVNETECNSVSLDYDSAISSKAAVNEKICPELCSSLERDGDAEMSEIEPYIQFQCSICYLNEKCIFGELKASDGFYPSAVFYMRDPFEPPQRIKGRKPILSDFLVIGSFCSLCNQSVCLDKTCSIYFGALFCTTCITRERRRFPDKVLQMVAKAQSLISMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y640</accession>
    <name>A0A0D8Y640_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y640"/>
    <dbReference type="OrthoDB" id="5905679at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="215" mass="25190" checksum="1FDAAD6F024F8EE0" modified="2015-05-27" version="1">MQIYKSRELFGEVYTPFKVTLAAVTSGVVSAPSESRNHQRRERCGYLMRTNLMWICLITIFLNRSAQYDRKRVDVLMLSCNLFIELKLSKCPGHEFGEYLRLYDIMLLMRHQQNYRHGVWTNTKDRHEGVIHLRTSIDQRKFARGKIFIFCSFYTITKQRKNDNPEYLHLTYGSERKLKKAAKSGTGLDFGNFYNANPISIEQVSVTMNIVNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6C7</accession>
    <name>A0A0D8Y6C7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6C7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6C7"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="408" mass="45573" checksum="F199397265AA185A" modified="2015-05-27" version="1">MCALMQSLESPVDYPPADPDVCIVTSQKKTVIQNFRPKNIVKKGHVTNDSESVLTKKQIAKATNQTISSSKKAKQSLISQSTEMTDALPDTTEEKQTDEFVPRGYCPDLVEAIEQTMSRNGTEVTWADIAGLDGPKELFKQTIVLPALMPSFFKVGYPSTMEGSVYGRTTRTGKTLLAKAVATECHTTFFAVNCGDLASKWRGDSEKMIKLLFEMARHYAPSTIFIDEIDTIGSQRGHANEHEASRRVKAQLLVEMDGFCKEDEGKRVLVLAATNFPWLLDEALRRRFEQRIYIPLPDKQARLSLLQSSLKEVRLEDNVDLETFAERLEGFSGADITNVCRKAALMGVKRQFYCSISLPRLTRTLTPAEIAQLTPEDVDLPVTWQDLQEAHSDTNPSVSEVILLSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6P4</accession>
    <name>A0A0D8Y6P4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6P4"/>
    <dbReference type="OrthoDB" id="5918127at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288:SF2">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288">
        <property type="entry name" value="PROTEIN CBG16535-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="234" mass="27141" checksum="D1B784CE79EDEF15" modified="2015-05-27" version="1">MCRGVRVKDEWTYFCGIWVRNRSIVIVLAIAQFFVATVSLAQHVYSVVNFNKVILMALYIHLLNRNKPYIQKILDILCSFNESFSIAGNFMSADVIIFDFGLFHELIQVQECIANYLDGGYMRCLWCFGQMIALALTIVTCLCVRHPHPLLLWPQLIIQNAYCFGLMILTIATADKLLVAILHPTSPHLSLLIMYFGIGTCSNHIFDYILWHYYWHEEFQYISRTGKNVIPFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7I2</accession>
    <name>A0A0D8Y7I2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Animal hem peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7I2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7I2"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF133">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29894" checksum="478E84A5FC0191B8" modified="2015-05-27" version="1" fragment="single">MEIDCHSSLLASPSLTEWKDLEGKPTFPVSQDTLEKVVNLAIHNLKDQQRREISNLRHNQRVFTKGDPLFAYSNMMRAKPQAKQISQMSAVLLETTKLLIKGEMLAEEERLPSLEIDVLQRVLPDIDVSTFVNNFTAFLSDDGQSTNDQCLPKMLPCDHTTRYRTHSGWCNNLKFPGYANAFSPLRHLLPPVYEDGFDAPRSRAKSGRPLPNPRRISNIVCEDRDVSHVKFTHMVMQFGQLLDHELTHSPTARGPNDEILNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7I6</accession>
    <name>A0A0D8Y7I6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716161">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16479" checksum="13D6FDD065652524" modified="2015-05-27" version="1">MLRMGRMVFDCEERLKKEPDRKAVTIERFRPIILVEKCFAWDEDNWLTVHIGDVSFQCLKPCLRCVMTTIDPTKGIKDPKGQPLKKLREFRVAPEGPMRDDCKDNPIFGVDAGIITPGYIHVGQTVYVRYKSTCLKPTPFYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24729" checksum="1DB16DC747E40AEA" modified="2015-05-27" version="1">MAAAGTGSRWDGLVTTNNRALQRQYDTDIVRSNTLLNAPNSIRTKLIDQKINIGDDQYGIVSDSIPTDRNVNVFEILQVFIKIVTIIELIKAAIDPWFYDCYYGIANSQVRIVEHCYKDIGCCQYGCCDNVDWHVKYGWAVALIVIFCILVVIAFVIWLIVWLINRSKDKRQKQDLIYEQSAFASPTLLQRPLAETRAPIEKYDYELPCSNVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y7X0_DICVI</name>
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        <submittedName>
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    <gene>
        <name evidence="9" type="ORF">DICVIV_00822</name>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
    <sequence length="441" mass="50827" checksum="0E78F1FD0E0296F5" modified="2015-05-27" version="1">MTLSFYNFLEAGLLFLNGIAILHRERFLNKYGFGATHSFESESETVKAQIISLILAVQTVMRSEFLLKFHGSLRPGDYLMAKLDRNAVLEYATFKIPYEELNMEFRKGHKARDAFRDFQMKLQQLDSVKREAVKKQRDFIKNMQSRIHFLRDEDISKEKGQRELELWQRDRQHVARLICVQMLRCGHIESAKVLAAEMNILNMVDLKVFSEVQRVISSLINKDIAPCLQWIAEHRSKLRRMNSKLEQVVRVQDAVELVRDNKVKDALLYVRKHLGASKDEWCSDAMKLMGLIALRSHNEVPAYKELLGAHRWQALADLFREEVFTLYQLPRQSVFAMCLQCGLSAYKTPHCSPGGVEKCPTCQPCAYALAEGLPYAHTVNSRLICSFSGEALNEENHPMMMPDGRVYGEKAIRELQVDNMVRCPRTGSMIPIDHVLKLYVL</sequence>
</entry>
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    <accession>A0A0D8Y7X3</accession>
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            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7X3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7X3"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="25617" checksum="FCA0F112A60EA993" modified="2015-05-27" version="1">MGMIDIAWLCILAIRSVYWLVLHACNFLGYSTLWAKNEIKQRERNVINRLVKVPAHLAIVINGMQLNKATLSSFLDVCLDANLRRVTIYDAMNDYSDLVRDLTLFCTMKRIKLVAGCIESSADTFSYRLFVQLLTADSGRSVLVKACRELSSSTTPLSVTDIATHLASKYSLSDPDLLIQVGSIPTLSGYPPWCLRVTEIIPVQSLPCSRLALEDCLEVFGKREIRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8C7</accession>
    <name>A0A0D8Y8C7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8C7"/>
    <dbReference type="OrthoDB" id="5857271at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="12100" checksum="03F384C96A7D6E21" modified="2015-05-27" version="1">MKGNLEIMKILKQIVTLSSGIKRADFLPSKQRYAYDNPKIQILFYVGKTDEDVWKAIQILREMERRIGGSTGEMAAFKKSLKEIRCDIAVFHQGVHGNKQQRRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8D6</accession>
    <name>A0A0D8Y8D6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8D6"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="20285" checksum="99CBDDFF7BB52EEC" modified="2015-05-27" version="1">MKDDYVVPNVLLSEIRHAISSARNRTASGPDRIRPEHLKSLPPVLIKTLARLITRYLSECKVPSQWKTSRTTHRSITRALSEKSLCLTFIDIKKVFDSVEAEAVMEALTNQALPTPYIKILRELYKNSTTKFTPFYKDKIINDHMLCPSLQNPQMIRLPNVNTYNEVERKQCEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8H1</accession>
    <name>A0A0D8Y8H1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8H1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8H1"/>
    <dbReference type="OrthoDB" id="203339at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000274">
        <property type="entry name" value="Mitochondrial RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="349" mass="39475" checksum="AC0D56BD8D3D428E" modified="2015-05-27" version="1">MSTMPVELAEEALEKKVEAMKVVDGNTMEVKKGIATDGRNERRERRFARMTDEERRRIWEEEQMSKKVVEVGLKGRVKWYSVLGHYGFISRADGKPDIFVHQSAISKSQTEKFYLRTLADEEEVEFDIVEGRKGPEASNVTGPNGGNVKGSKYQRVLLYRFRPNRRHISHEKEAGKKNGPKDNNVKVTTDGDAKKPSRVKRQGRRFRGRRSRQPPANETIEGASMNGVEANANTEDITNVKPGPRRRSNYYNRRFRRQVKHDVKHENDVDNEVQFAASFSIVFVSITRNNKLNASNSSGMAAESENGNDEEPKAGMRRRTECEKDAQLKTTDLGGGDVNAEGCRISAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8U6</accession>
    <name>A0A0D8Y8U6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8U6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8U6"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="866" mass="97613" checksum="C5F968F58042AF9A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9D7</accession>
    <name>A0A0D8Y9D7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9D7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9D7"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF7">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="16960" checksum="35851C1B7655BBA8" modified="2015-05-27" version="1">MPLIMGPFISSLFSPNIYDDTVYGFVDVGFEEVLEEFRRNFGEGLERDGAAIAVYHRGKLVVDLWGGYADRESNVIWKRNTRTVLFSATKAISSLCIAILVDRGLLQYDDRLVEFWPEYGSYGKENTTVEDVLTHKSDYNDAFEQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9L7</accession>
    <name>A0A0D8Y9L7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_00938</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9L7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9L7"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="14">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="12">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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</entry>
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                <person name="Rosa B.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
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    <dbReference type="Pfam" id="PF00089">
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        <location>
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            <begin position="38"/>
            <end position="269"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363034"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="279" mass="31228" checksum="6F22CB629A992466" modified="2015-05-27" version="1">MNRIVLVLSTFVFLPIFGASISDDFWRPLHADQVEFRSIGSTLARNKEYPWTVGLKVSTKRCSAVLISTRHVLTAAHCVTMTIKDRNSKIGCRFVEFLESQVKIYPGTRVKDMLNIPLYTASFRVVNMTIHPKYQPCSRGNDLALLELSQNMFSDGLPICMPDANETIPENLTFTGFGLNPEDPKRAMLQAVNLTFYNTTIYDEIVTFTLDKAPCSGDSGGPLFTKRNGQHILLGIAYASAKCQKDNTKKQAIFDNVRSQIEWICEVSGVCTTLRLNGQ</sequence>
</entry>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="124"/>
        </location>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14015" checksum="A12D20DE4A35ABE8" modified="2015-05-27" version="1">MSINPKQKRLLIPNGETVSSTNHEYKIVSLLGSGGFGHVYKVQQIDTKQFYALKTEDVDIDSRLNRLKVEATVLSACGKATYRQHFLRLVDRGVTSKFKFIVMPIVAWSLDKIRKDVLNGAQFS</sequence>
</entry>
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    <accession>A0A0D8XAM1</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717057">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAM1"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <dbReference type="EMBL" id="KJH40669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16838" checksum="4562754DCD08E661" modified="2015-05-27" version="1">MSFHSRRHSNNFLIEPTNPFLFPRSAISCRNFLFFRNIGKTNGRGSAAGYLFHTTYNGSECILNASNVKLFIIDSLINYEQSIFLVQQLLTFFFEAVQLKKNSRQLVINDNKAVVSLPLTHTHFLKIINNYPAHHQYRFLAVILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAX9</accession>
    <name>A0A0D8XAX9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_12267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716766">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8534" checksum="87F600357B94F4FC" modified="2015-05-27" version="1">MLYNVFHPLVRRPGSKISAALFHVAVCLEFSKLVQSLSSKLRDMHRNYENEIKMLENKSDELNEKKMLLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB18</accession>
    <name>A0A0D8XB18_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716996">
        <property type="protein sequence ID" value="KJH40844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XB18"/>
    <dbReference type="OrthoDB" id="5858751at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
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    </dbReference>
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        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="Flavoproteins"/>
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            <begin position="18"/>
            <end position="38"/>
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        <location>
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            <end position="221"/>
        </location>
    </feature>
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            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40844.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="29641" checksum="5F250CBC48808A62" modified="2015-05-27" version="1">MAAEQPGPPWIHDGEDEILLYFTAFLGVVLPAVVYFIYHKIHAIYMKYAEKKESERLADEAARSEIVIISLCTEDSPAERFSTHLQSLLTEELINPPILWPIENLNTKDLMNFKGFCIFVVETLTNGKASRQSEWFLEWLEDIAADVKQKKKAHFEAVKFAIVGFGSLIDGESYYNKVSQTVLKRMKILGSKQIMSVALFDTSQPELSFSKKYDELAERLLQAIDRNLPGVHGDNETDSMSEWSDESEEERETHDKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XCW5_DICVI</name>
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        </submittedName>
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    <gene>
        <name evidence="12" type="ORF">DICVIV_12403</name>
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    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716788">
        <property type="protein sequence ID" value="KJH41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Emp24-like"/>
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        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
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        <property type="entry name" value="GOLD_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD37</accession>
    <name>A0A0D8XD37_DICVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716655">
        <property type="protein sequence ID" value="KJH42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD37"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8197" checksum="3B53D3B557C09F0F" modified="2015-05-27" version="1">MDLICNSYTSWSIVSLTLIGVRNSVDFSLCAVVEDLAQKIPWVVPHVPFFLTLPNTDLSTVDGKFKKKASNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDG3</accession>
    <name>A0A0D8XDG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">DICVIV_11335</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716640">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17580" checksum="F26BB1E04B33D363" modified="2015-05-27" version="1">MADDLHDVATYLADMRLCFILVTATGYLLIFIYFVMICIRRNRRSQPRRRNFDYHVENQRECNASGAQNNDDLTTVRSDGNLSYIGRNHHGRGHNIAPSFMRHGHINHQQTTRLMADQDGSVVKHQIPHITTEPPAEENKAKIPQLVKDSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDJ3</accession>
    <name>A0A0D8XDJ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_11326</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716639">
        <property type="protein sequence ID" value="KJH42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDJ3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDJ3"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19032">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000035">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022268746" evidence="17">
        <location>
            <begin position="22"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="232"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="506" mass="58108" checksum="9BF6A011C1FA2A5B" modified="2015-05-27" version="1">MRFSITFITVISIALLFRVFASDDEERLMMDVFRGYNSLIQPIKNLSNTPIIVKIALQLVLLINVDEKDQVMHTNVWLTLKWHDFQMRWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVINYLGDMLWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFEQAEWVDLSEYAPSSIWDVMDAPASLVNKRSRIEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPTDSGRCEKMTLTTSVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIIDVYFRGPTTHRMPRWVRRLFLELMPHAMCMRRPKSYSRKSSTEKQPSTVTTTELPGLGTFNFTLAAHHPFCPSATEKEVMSLEAMNSGVASEVGSDPTVSAFYPLSIDALRAIDSIEYITDHLKNEEERKMYRDDWKYVAMIIDRLLLYVFFGITVGGTCGILFSAPYVFQGVNQREVLDRLISLYKNGGDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEB5</accession>
    <name>A0A0D8XEB5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_13284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717027">
        <property type="protein sequence ID" value="KJH40751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEB5"/>
    <dbReference type="STRING" id="29172.A0A0D8XEB5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="25175" checksum="13FD4DEBF64214D7" modified="2015-05-27" version="1">MVSLEGEKRSSTFSVESILERKNDFFKPQPVAPAQPVVVPAVVPIPPYSLKFAYPFEPSMMLFGQSRLPLPVSECSPESSGSSPHSLAPVQWMGNFSTRNESPISEDAKIQMGLSKCMLRKHKNNRKPRTPFSTQQLLSLERKFQQKQYLSIAERAEFSASLQLTETQVKIWFQNRRAKSKRLQEAEVEKVKFAHASALAAAAVVNVQNDPSKAFLAFGYPSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XED7</accession>
    <name>A0A0D8XED7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14799" checksum="E2901D96CD6E65D4" modified="2015-05-27" version="1">MKPRWGWGSRERGGAWAWQHGVGLAVVRRWSSHTRVAHEEFHRVTTTLMMFIIILQLFVVIFTFLHAASIFDQTSKGKCQPIEIPLCKDAPYNYTYFPNPYLQQDQQSVSDIVYFLMLSLSTVDVCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF77</accession>
    <name>A0A0D8XF77_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Cu(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:secretory granule membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:norepinephrine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DOMON_DOH"/>
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    </dbReference>
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        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0186">Copper</keyword>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="38844" checksum="1B84B782540EEEDA" modified="2015-05-27" version="1">MQTNFRLAYLIIGFSDHGSYNNSDICIYRNNKLRDGYIDANFQIQFDRSQDCQLEKRNRNTFSFRRRLATCDPYDIFLESGTTQFILAGGYEFSRNFNSDNVMKMSIIFEMKFGNLFQTDSTQVLEFESAHFKILADGARISHDVTTYWCVIKRIPVAVSRQKHHIIQIMPQIQKGNEQLVHHMEVFMCESDDQVEYSGKCDSLARFRNAQTCSHVVAAWAMGEEPIFYPPEAGLPIGGVDGKKYLKVEIHYNNPARLVDIRDDSGFDIVITPNLRKFDAGIMELGIIYSDANSIPPNQASFPLTGHCVADCTMKLSPAPVMRFEISSANHSAENLVPSLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFJ2</accession>
    <name>A0A0D8XFJ2_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_11517</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716659">
        <property type="protein sequence ID" value="KJH42492.1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="538" mass="61333" checksum="69D8D6454F16F4CE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGQ3</accession>
    <name>A0A0D8XGQ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="7" type="ORF">DICVIV_12472</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716801">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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                <person name="Rosa B.A."/>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="12005" checksum="01465F631F7212FA" modified="2015-05-27" version="1">MDMQPRPMWRTICNQHLMTSTGFCDFVEEEGNRQAANVRERKRMCNINVAFIELRNYIPTFPFEKRLSKIDTLNLAIAYINMLEGVLRFDCKTQLGKVEATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ87</accession>
    <name>A0A0D8XJ87_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="9">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_09331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716458">
        <property type="protein sequence ID" value="KJH44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ87"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ87"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="11">
        <location>
            <begin position="217"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="41683" checksum="EF37F8B04646A4BA" modified="2015-05-27" version="1">MPKYIQFLEFGGSMTVDEITRFVDKGGNLLVAGGVNLGRAIRELAAQHGFEFDESDTMVIDHNNYDTYLDDGYHTTVIATEQQVIDAAHIVGDAAKLNPILYKGISIIPHMKNLLCLNILWGSSTAYSSNPKAVVDEYPSVIGKQLLMVGAMQARNNARVIFTGSLDMFSDAFLSAYVHKAGSDEAAVRSGNFDLVSSFSMWVLKENGVLRVKEVKHHLIGKKDVPQEYTIMDDVEYTIVIEELSYGKWRPFTSKDVQLELVRIDPFLRTTLFSNNGRFSTRFKLPDVYGVYKLLVDYRRVGYTHLYDVQQVSVRPLLHNQYERFVRSAYPYYASSFSMMIGVVIFSLVFLHFKEPTKDMNRLKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ90</accession>
    <name>A0A0D8XJ90_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716672">
        <property type="protein sequence ID" value="KJH42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ90"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ90"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF932">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="199" mass="22639" checksum="371B6056FEE33FF8" modified="2015-05-27" version="1">MSVLVLLICSLLAVILLLPVLIQSSVFRINKMSMVQLDEGSEELRLSDLHGTTISKCVFDSDATFTLYTFTIGFALPAVLITFFYAQVTKRIIAVILFYFLCWTPQWTLNIMSQFNLVHVSWTTPALSAMFFVAHLLVCFNSAANPVLYALINRELRQQHVMAMAKKRQSFTHATHEALEFVSRHRRKFALSLTSLICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJS3</accession>
    <name>A0A0D8XJS3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716445">
        <property type="protein sequence ID" value="KJH44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJS3"/>
    <dbReference type="STRING" id="29172.A0A0D8XJS3"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9627" checksum="D6E0B5638A614AD4" modified="2015-05-27" version="1">MVMSFDEAATKVKTLKTSPSNEQLLELYALFKQGTIGDNNTDKPGMLDIKGKAKWSAWDSKKGMKQEDAKAAYVELVEMLISKIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK32</accession>
    <name>A0A0D8XK32_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716438">
        <property type="protein sequence ID" value="KJH44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK32"/>
    <dbReference type="STRING" id="29172.A0A0D8XK32"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="302"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="649" mass="72843" checksum="AF34294B6FB399D8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKN7</accession>
    <name>A0A0D8XKN7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_11099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716612">
        <property type="protein sequence ID" value="KJH42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XKN7"/>
    <dbReference type="OrthoDB" id="10254995at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="9">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM26</accession>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="16679at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
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        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7145" checksum="E9E43C953CE42E2D" modified="2015-05-27" version="1">MAPKQRMTVANSQFSKNVINRGNVAKSLKPQEDKYPVAPWLIGLFLFVVCGSAVFEIVQYVKMG</sequence>
</entry>
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    <accession>A0A0D8XMU8</accession>
    <name>A0A0D8XMU8_DICVI</name>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716382">
        <property type="protein sequence ID" value="KJH45855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="160"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="337" mass="38579" checksum="58855EEE6325254C" modified="2015-05-27" version="1">MLIKLLLLLKVVYSEVVTSEVNFILSDECLKNFFNVVLRNLRPYKCEQCGTEFGRAGGLRRHDSMVHQQKKHACPYEGCKHPGYKCTKALAAHIRSVHTLDRPFSCLFCDRTFVRKNDLKVHELTHSTQCEFLCNKCNSSFRRLIYLQKHEKRCSGGLKRRRLNRVSGTDVYAPNSQLVNSCDSDESMTRVSSEFDYEEQLLSSGFSGATGDESLEEVDPLIVIEDDNLEICDDDGIVKKECPEIVDDESLEEGEIDENQTSLISMHDNEQILPLSIDPKTASTPMLKEEQRINFGWLSRKNLRFEPREEAVVPKKRRRCSFASLSTFSLGKLPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMX8</accession>
    <name>A0A0D8XMX8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cadherin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716427">
        <property type="protein sequence ID" value="KJH45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XMX8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cadherin"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="23482" checksum="D37FE6104A0200E8" modified="2015-05-27" version="1">MIHENFHIRVFASDADVGKNAELFYNITNGDPRFSINENGYIATNTPAKAEEVFTVTIQVTDRGLPPQMNQAKIIMTAIATKERAKGVVNRAPEFVKNTSKKIPVSDADQVGFTIGKFEAMDPDGDTIWWSIIDGNLNDTFSLKSDSGLLQLSKPIESIHHNISSLILLIQISDGELNDTTEVNYQYSFTSLVIFYNYESKYVEQILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN36</accession>
    <name>A0A0D8XN36_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="19">3.1.-.-</ecNumber>
            <ecNumber evidence="19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DICVIV_07995</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="19"/>
    <dbReference type="EC" id="3.6.4.12" evidence="19"/>
    <dbReference type="EMBL" id="KN716377">
        <property type="protein sequence ID" value="KJH45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XN36"/>
    <dbReference type="OrthoDB" id="5871723at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="21">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="21">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="544"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="23">
        <location>
            <begin position="649"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJH45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="878" mass="97712" checksum="A8CF6276BBA1265F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNA6</accession>
    <name>A0A0D8XNA6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716373">
        <property type="protein sequence ID" value="KJH46030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XNA6"/>
    <dbReference type="OrthoDB" id="5837492at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
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        </location>
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        </location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="485" mass="55148" checksum="3DDBE2A0F6466F81" modified="2015-05-27" version="1">MPMQNIGVAEGEFCRFETQLAPINDPYMKIEWFKDKKPVLIGHRFRSTMDFGFVCLDLLYALPDDTGEYLCVATNKYGRPSYDWSETGVSRRITRDNRQSDAARNAGAQRKEGQHEDTLVTENEPARFECAVIGYPRPKGHRYKLNYDGMHYLTISNCRISDAGEVVVIARNSEGEVQAACTLDIFQVTENEPARFECAVIGYPRPKGHRYKLNYDGMHYLTISNCRISDAGEVVVIARNSEGEVQAACTLDIFQVHHLNLATSKKAMHFLVSVCISQKKDWRQKQLKPAHLMTSEELQQRQSQWQKETLGTLGEAFDAAPKPDARKLLSVERSRTPIEPLETEELLQKFTRPRDEQFYDQLAYVIYFNVETAKPHFKGMELEPVQLKPGQIERYQPPREEMESVALRAVPTKGKAVVPPTDHPDWAQEGGVKLPCNVDGRFKRLSTPPKEVDIPARDQVALKTAKPKPASEDHSLTHDEQLVVK</sequence>
</entry>
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    <name>A0A0D8XNF3_DICVI</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="28023" checksum="98D3D5B204684BC7" modified="2015-05-27" version="1">MPAGRLPYLLLESREFFAATIDWSDRTFLDESSHNPFENNGHSPRFVLSSWGECSTTCGPGVRIRSAECVAVHPIAGMIRLPYTECQGQTQPSLFESCEARPCPLQEDSKANNEETLFKWENGDWGPCSASCLGGKQKAALLCRETSSGRAVPWSHCDARTRPPQLVRQCNQHACPPLWEVGAYSSCSASCGGGTSSRSVRCVRPISFFALLKSLTSTSSRGADTHVVLRDFECPLPKPSENEICGAVQCPANWVF</sequence>
</entry>
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    <accession>A0A0D8XNT3</accession>
    <name>A0A0D8XNT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_08531</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716409">
        <property type="protein sequence ID" value="KJH45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="47" mass="5352" checksum="9AC7B08262B9855F" modified="2015-05-27" version="1">MRLNEGNKEKLYLNTAVILIKYGLVANICIKMITASKTYRLLRPVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNX8</accession>
    <name>A0A0D8XNX8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716363">
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    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17102" checksum="D42AFBC175E5F8D2" modified="2015-05-27" version="1">MDTAPFLQIHCQNTQNVSGVGYVVHPSVVHLVDSYEIPSPCLAKFRLQPRLRKKISIINWYSPTGVANESELDAFHNELGKVMQNEKSSYKLVVGDLNTRMGTMDEKHYRIGKFGLGDRNEGGECLAALLSTACLFHENAFFVKKENRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP99</accession>
    <name>A0A0D8XP99_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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            <dbReference type="Pfam" id="PF01576"/>
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            <dbReference type="EMBL" id="KJH46355.1"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
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    <sequence length="780" mass="89712" checksum="6089D4DFB3078BA8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPW2</accession>
    <name>A0A0D8XPW2_DICVI</name>
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        <alternativeName>
            <fullName evidence="10">RING-type E3 ubiquitin transferase RNF170</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
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            <end position="37"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    <sequence length="260" mass="29552" checksum="A4952D7EFA96BD81" modified="2015-05-27" version="1">MLKDIGGQVIEGFSNEALILITVVVASFIVCTANYLLRESRAFNIHPDLAVDVQGFRESHVRGQSGRVNETNRILSENADSDRICPICYGSALYPILTNCGHLFCCECIMGYWRHAASLVSPVNCAVCRTQVTVLLPLHWPNEAEDNQLHENNIALDDYNRRFSGDRPWVEYLWDLPVLIPYILRNLFDFNGFMIMFRFRIFFVIVGIIAYVLSPFDIIPESAYGIIGLMDDIFVSLLLLVYIVIAIRHFMARRGEAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XPW5_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        </lineage>
    </organism>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716344">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="15991" checksum="1E61DDA07A07D53E" modified="2015-05-27" version="1">MISVLPSVGEKKTMLIDQNFASTVGKCLEKRGKQISTRKDDNVSTFNETFLSHLKEERRKFIEMLDNGHFINEQRRLVEEMLDSYHYEKNVHPRIDHLQPTRVNVSMTLYQILEVWMLHIADYPLESNLKRITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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            <begin position="58"/>
            <end position="83"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46703.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11383" checksum="AFC2418D3A18F203" modified="2015-05-27" version="1">MATNASIENTTVLNSVTLQQTTANPLMIHQSITHGTNQFLSKSGAINNNTIIEAEYNWLLFFVLVGLAIFLVFFVIPVLIILLQNRSNKIRRMGKTYSYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ37</accession>
    <name>A0A0D8XQ37_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="33708" checksum="9796922B70411EB4" modified="2015-05-27" version="1" fragment="single">FDTSSESCVWESDGLTLDSIERRPPLQRSFVAKILHHFPQKRAGAPFSDEVLSEVRDSRICEAMSLLHTEHVRKLTAEEPSFDRERMHVPPGTVSGGTHTLPRGRKNKTKRISYYDGGTHNTLFMSKTLCLITRLPLVYSTTTILKTLHEVLISDTKPILPVESYIYWILNEIPLPLPGTTLKVSMLNSTILVQRPGLRELPIFDDSLGAMFQVSCLVNLCILLSGYLHTLFLYSIFLVNACYYLIEYSRLMCVSEALCALAFPFRWQMVYVPILPYSQLKFVEAPVGLFFVGAQKQ</sequence>
</entry>
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    <name>A0A0D8XQH7_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716329">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11648" checksum="E3650653811F81F1" modified="2015-05-27" version="1">MDETTASPSNFRRTQSCRVPQTQFLTHTKLRVKTPESTVLLATKMFASLVVEDRSENNRNIYIHIFISINNMTSLFMLSFESGFFLNHRDYAVDKLYSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQK7</accession>
    <name>A0A0D8XQK7_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716334">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="255"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="415" mass="46768" checksum="00DE0E40AB1F1A06" modified="2015-05-27" version="1">MAMLQECLWFIMEPFLIKKETTDFEFIYRLLQDIKASSDALYEKKHKDEEISQAQVMGQNKKMWALADLGMLMLVYRGKVAIRNEPRKPLLSSRFFLRDKCTEHAATVYAPEELIEDEKRRNGKVPTDEKRRLNMTTKGRFTARTGTKNAVNIKKCHPAAEKEMDPEDICTSPKHPIKLEAPQVPKRANRKPLKIEQASITDLGEVKDRESINALNPFGFVSILLVCTTTRSSLKRQKTKDNQVSTIENGAAVLPSTSKEQLPQRSLRSHSTHQLSFRKTTLDKQSLLHSENEGSSCSQSKENEKNSSRSQLSLEKLHEYVDLSPITRSTSKAFPKDRSRRKPLLTSTPLHTAVSNSPKSKTGGKKNGQARVPRTSQKSNATKVPKNVAGSKIASKARKLSTHTKTATKTRSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRA6</accession>
    <name>A0A0D8XRA6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras family protein</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_06892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716323">
        <property type="protein sequence ID" value="KJH47040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XRA6"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH47040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="192" mass="21618" checksum="905BD739C66CA5AB" modified="2015-05-27" version="1">MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVRHFCPNVPIILVGNKKDLRNDPQTVRELSKMKQEPVRPEQGRAIAEQIGAFAYLECSAKTKDGIREVFEKATQAALQQKKKKKSKCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRQ7</accession>
    <name>A0A0D8XRQ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRQ7"/>
    <dbReference type="OrthoDB" id="5860330at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="48083" checksum="88893A91BB8A3892" modified="2015-05-27" version="1">MGKTYRIPHLPDVVLYHIFGFLDYQQLCKAESVCRRWQSTVMSLMRRHIQEITIERQFGISTPSVSHLMAFRRLAISCPLEKFDFLTGVLRRSHSSLFRMTIDVKILANLAQIAVNKDEGGKYFPNVEDLWILIIDCDDVITNRFLRIENQLFNKITNLTIQVHIVMNFYNNVGKVCKALTDRHKNANIQFEFHAPFSSMVMIFQLFFINRFFLHHFTASVPSCMNIFEVFGQLFELHSFHASRIKIICTEFNLPTFRLDRLYTVAKERDIRTNNLVVRDWTILVNVTMPIIAYPLDTLRISSCTIESVDDLIESLRVTMEEEFSIPTSSTEKRNATVIDKDTVKLSQQKRVNETTKKANRILYLKKLELAGQCTLCGLQFLQSEAHLELEKRLKVAIPEVEVDCKEIYYCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRV0</accession>
    <name>A0A0D8XRV0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716351">
        <property type="protein sequence ID" value="KJH46479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XRV0"/>
    <dbReference type="OrthoDB" id="5829828at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36288" checksum="AD7FABF389FBEE65" modified="2015-05-27" version="1">MESIGDQQHYDNRLNDEHSMLICDVYKKKKKSTLKNPSHPLDSSLSPSFVGLIMAVSGVGEAVTAPILGYWTNCTGKVLQPLLASVALSIIGNLMYMCLNGFSLMWRTYALLLSRFLSGAGSGNRGTYFAYIAATSDTTDRARSMALSGGGALIGLNIGPAVQILFTWIGDEGIDLGFMRFSMYTAPALLAIIINVICVFILLFYLDDGLDRFNDPNTDNTSVYSIAADSDTDLERNTVRSIRLDVLAVIVCMWTRAARMLITANVDSIGSPFSEVMFGLNNKQILNYNSIMQGAVGVLTAFMFVVYVFTDYSKRRQIQSNGLGNLIQFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS28</accession>
    <name>A0A0D8XS28_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716343">
        <property type="protein sequence ID" value="KJH46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS28"/>
    <dbReference type="STRING" id="29172.A0A0D8XS28"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF133">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="415" mass="48692" checksum="A7C37CD3BE2C3ECA" modified="2015-05-27" version="1">MSAKQYARLVPKKHRAQRTPVIDRPMRPRMIAWAGPSAFYPNRFYEIDKWYKGRIDKPEQFPKLHTIEPTNHLHSLAEFLSREIPKHPAINIGFAPRVMPMVTVKNDEDRSKLERKSRKMELRIDYESIPFSSTTVLKHYGIFDHLFGQGVFFENVQTLDITFGDSPVFFGNTLSACATSSKPKVEIESLKAGEYNTLIMLNLDGNPFDKEGEIVHWMLANRLDDENQDPGEEAIPYLQPLPFCGTGYHRVAFVLFRHKERLNNLPKLCSGSLDERVFSMSHFYKQNEDIITPSSLLFFQTSYDISVKERLHAIGLKSPIYEYKYNEALKPEQKEFPKKPQPFDLYLDMYRDPKEVEQELLVERLRRAQLDDYEAPKWLDPNYNENKRVLPAWQHRRILAREGRYRALYDNVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS39</accession>
    <name>A0A0D8XS39_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cadherin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716312">
        <property type="protein sequence ID" value="KJH47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XS39"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="323"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="442"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="724"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="819"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
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            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1322"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
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            <end position="1532"/>
        </location>
    </feature>
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        <location>
            <begin position="1533"/>
            <end position="1634"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1658" mass="186046" checksum="4B31B2EBB1B5AE1A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSC0</accession>
    <name>A0A0D8XSC0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunoglobulin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716417">
        <property type="protein sequence ID" value="KJH45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSC0"/>
    <dbReference type="STRING" id="29172.A0A0D8XSC0"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="435" mass="48919" checksum="11973BCA95D0C69F" modified="2015-05-27" version="1">MECSASCGSGEQKRSVVCEGRDAKGRRQRRPEKECSTEKPPEIQMCSLGPCEKPQLLTNRVFEQNASEKKLTLGIGGVATLYQGTSIKIKCPRKNFDKKKIYWTKNGKRIRNDAHIKVSANGNLRLFHARMEDAGVYECYTNTLQGNVTLRFKYREDDKPYRAGLASSTDKNKWIRKNGSLSEEKKTVDIFCFVFFLAKIQIRSKSILSAGSYAEVAKELQKHRDTIQARWEMGHWSDCKQSTCGVAGFQAREVSCSVKVDGVRRRGDARICTALASSRPPETRPCHKSECPRWEAGEWTEEEPVVIGRIQCSTATCVRNAIAKQRRDVKCLMPNGKQVDEESCDRTQRPKSRKECENRECKAEWHASDWGSCSSNCGTGGVQLRLLSCVWTITRLPAGRNCEGRRPPAARSCPHADSLPPCRPTALPLQQGVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTQ0</accession>
    <name>A0A0D8XTQ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTQ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XTQ0"/>
    <dbReference type="OrthoDB" id="5786609at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7419" checksum="F2FAC063C5258D02" modified="2015-05-27" version="1">MSWCDNDARIIGVNLDFIKYNHEAVKAWRLLLAYITDELIVGFDRLSRISDRKISGGDSYARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-10-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTT1</accession>
    <name>A0A0D8XTT1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716387">
        <property type="protein sequence ID" value="KJH45771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTT1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="59" mass="6581" checksum="030B187E74633CBF" modified="2015-05-27" version="1">MIRGDKDSCQGDSGGPLACQNERNDWQNMRLQKATSKVDYCNAAETFNHSSKNDCTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTZ3</accession>
    <name>A0A0D8XTZ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716285">
        <property type="protein sequence ID" value="KJH47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTZ3"/>
    <dbReference type="STRING" id="29172.A0A0D8XTZ3"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="10">
        <location>
            <begin position="68"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    <sequence length="315" mass="34944" checksum="973E948C7E0A8DD7" modified="2015-05-27" version="1">MLRMFSVSALSAVTIGDVPLEHKVYKLFYDDQLMSFQRGVIFSPCGQLIIAPCANLEAGTRGNGALYAEIFWHDRKAMLSVDSHPVTENGAYRIVASGVQKEVRIWRFEYEQSAKISSKYQLAVTFLANLAGHNVAINQVKSSQNPELNLLASGDSDGRIAIWQLCNTPISSPPIDDLPPNKENWIRIRVLNHDNEVANLAWSPDGKLLASASSNESLLIHDISNGKRCVTVRNLRHFPSGVAWDPKGKHIVTMSTDRKMDLIGAARGRRLRMFSVSALSAVTIGDVPLQHKVYKLFHDDQLMSFQRGVVFSPCG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    <sequence length="100" mass="10819" checksum="E9BFEFDF3CDA6870" modified="2015-05-27" version="1">MSISCISFHAETQQIEVIKSLPKTGIEPVSPRPQRGVLTTILLGPMSISCISFHAETQQIAVIKSLPKTGIEPVSPRPQRGVLTTILLGPMSISCHIVYI</sequence>
</entry>
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                <person name="Hallsworth Pepin K."/>
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            <strain evidence="5">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="12">HannoverDv2000</strain>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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            <strain evidence="12">HannoverDv2000</strain>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF61">
        <property type="entry name" value="ARGININE KINASE ZC434.8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="300"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="348" mass="39045" checksum="8613324B259B8BBB" modified="2015-05-27" version="1">MAVPKDTIKKIEDGFAKLQGAADCNSLLKKHLTKAVVDKLKAKKTRLGATLLDVIQSGVENLDSNVGLYAPDAESYTLFADLFNPVIEEYHNGFKATDTQPPMDLGEKNLAELPNLDPEGKFIVSTRIRCGRSLAGYPFNPCLTELNYKNMEKRMQDILNGIPDEELKGKYYPLTGMDEQTKTALISDHFMFKEGDRFLQAANANRFWPTGRGIFHNEKKTFLVWVNEEDHLRIISMQPGGDVGAVLGRLIKGLNYISTKAPFARHPRTTVRASVHIKLPKVSAKPEFKQICDEMKLQIRGVHGEHSESAEGIYDISNKQRLGLTEYMAVRQMYDGVKKLIELETAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXD3</accession>
    <name>A0A0D8XXD3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="2">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_04562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KN716239">
        <property type="protein sequence ID" value="KJH49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXD3"/>
    <dbReference type="STRING" id="29172.A0A0D8XXD3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18598">
        <property type="entry name" value="ABC_6TM_MRP7_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000037">
        <property type="entry name" value="ATP-binding cassette subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH49298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="33566" checksum="558ED1AC38AD027E" modified="2015-05-27" version="1">MIENSPTFYSDGQQYSLSSSLISTFGWSFFSLAILRLASDAFTFAGPILLHLLVDVLEDPVPNPMGFLYAGLMVLFSLLAAFFSTNFNFYVNKIGLKVRAACITTLYDKLLMVPATEMNAFSSGAILNFVSTDVDRVVNFCNSFHAFWSLPVQLTIALYLLYREVGMAFLAGVLAALILIPINKWVTNSIGRMSVKLMHCKDQRIKVVRETIEGIRAIKSSAWESFFEMKINEMREKELYYLKIRKYLDAVCVYMWASAPLLITISILTTYTMVFHLKLTAAKFFRHNNIETLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXG1</accession>
    <name>A0A0D8XXG1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716244">
        <property type="protein sequence ID" value="KJH49170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXG1"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="26573" checksum="32379AB75DF11FB0" modified="2015-05-27" version="1">MLKRGRVGRRRKPKKKPADTLYLGHSPKSQIPHNPRQNLPDLHKTNGRKRFYRNIHSIRLSFELRQRQRNMKQIFPNSKKKNQFGYYGRKKAKRSALNCRITPFAAATRTRAVANGSQDGTRHRSFVTIHEEIRHSLSEKVLLKMPGRNNVFDSHISLPPFKGSKYNYVALSFLHSKIRHAISSIRNRTAPRVDKIGSEHLKKQLPVFMETVARFFTCYQSECKIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYJ1</accession>
    <name>A0A0D8XYJ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716255">
        <property type="protein sequence ID" value="KJH48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XYJ1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="633" mass="72836" checksum="A16E2B9DF970F5A2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYL2</accession>
    <name>A0A0D8XYL2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYL2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="9273" checksum="5618C8E56CD3D7EA" modified="2015-05-27" version="1">MKWRGDTPADLIPCARIRYRISDDVHSEDRGEWRSQSTPLEGSQEIELLLCKEIRSKLCNMKVFLEKNLLDADARSPVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYS3</accession>
    <name>A0A0D8XYS3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_04245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001067">
        <property type="entry name" value="Serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="27915" checksum="43202577AAF36277" modified="2015-05-27" version="1">MATRVYIGRLSYRASERDIEHFFRGYGRIRDIVLKNGFGFVEFDEPRDADDAVYDLNGKELAGERVMLEFSKRGPRAGGGRGFDRYPPQRRDARQTLGVVHFMEYIKCHDEAGCFDNLHFRSMHSAVCSCSRMIQVSGVARSDMFGSTLCLSLQLNFRLGDQRKRNFGGRQGPEYGPPTQTRHRMIVENLSTRISWQEVPRDVCTFGVGRRGCSMYDGLVDGEQATEHADGEINHGYTGLVVRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYV9</accession>
    <name>A0A0D8XYV9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2 5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2 5"/>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XYV9"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="55"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19490" checksum="998FA63821E97996" modified="2015-05-27" version="1">MLTRFVCRLVVTQQSSLPTINIIGNIVRNMSGKHGTDDIGTKKLGDVKDPKQVSEDEWKKVLPPETFEVARKSGTEPAFSGAFDKFFEKGRYVCLCCGAELFNSDSKYWSGCGWPAFSKSIDNDLNIVRLEDNSHGRKRVECNAHLGHVFNDGPKDTGERYCINSVCMAFEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZC9</accession>
    <name>A0A0D8XZC9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZC9"/>
    <dbReference type="STRING" id="29172.A0A0D8XZC9"/>
    <dbReference type="MEROPS" id="M13.A31"/>
    <dbReference type="OrthoDB" id="5825897at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF192">
        <property type="entry name" value="NEPRILYSIN-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="21171" checksum="C3A6B0594D502A68" modified="2015-05-27" version="1">MKNELRNGTLPWLSTKRRSTVRITGLVNRGISRQWRLFSYQGLPIYASSYENSSVGVDRTAINHNGIVCTSRECVTIAGFLAGNLNDKVDPCEDFYEFACGNYGLNRNLPASKPLQHTISDVQSRLNKQIKSILQKHFKFAKNHYEVFHENSPTYSTRSNSENRMRSLATRVLKKKQHLCIYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZG8</accession>
    <name>A0A0D8XZG8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XZG8"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="13905" checksum="91D47D9ECD3610CD" modified="2015-05-27" version="1">MASYDLLLERVGSQKHLLRFWNELSECEKELLAQQINSIDFRSFREIYENSANLHTVCPDNLTPVLDSHHIVFKDLCEKEKQYYWMKGLSAISRGEVAVILLAGGQSSRLGSSAPKGYLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZU7</accession>
    <name>A0A0D8XZU7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrator complex subunit 14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZU7"/>
    <dbReference type="STRING" id="29172.A0A0D8XZU7"/>
    <dbReference type="OrthoDB" id="5792636at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="1">
        <location>
            <begin position="358"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="449" mass="49765" checksum="FD2D157DB4B771A9" modified="2015-05-27" version="1">MVVFFIIDGHQPNNITNRNGVKVTRNSIYVEVIKEILPNMSKRNSDLEIEVFWGNTSCIRSTVTSADVIPAIENSIVSSIGSLHLGKLFDKIRPKMKPSDSVVLLTDAAIFKADITSYPLGMMFVIIVDIIPTNSDQISELKELVTTSNNDQLSDANAKLWILHYSDYNDVKRLASELLKSLLEPDFTMLYVGNLTASISIYPTSGRDVPECIEVIGFVRSANMVNIPIDGVQFIKPSPIQKLGAAKSTGKHSPADDHSEFVRTEEQSSEDLLGTLGPSLLETECVALVLINEAKFGCITAEKVGDDVCLILNKFPSKMPDFVPDFATLVSGPDELGDALHYTTLKGIAPSYGPVVQSWVTEHGLNIDFQKMMRLLRKLPDRPHLFYQEVNRFRSYALAIGMDHILHEAARIIREEIVQLNAMAQKHGAYVATAFVMENPRDTAEIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZY0</accession>
    <name>A0A0D8XZY0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZY0"/>
    <dbReference type="STRING" id="29172.A0A0D8XZY0"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF176">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="437"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="551"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="642"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="879" mass="95863" checksum="BDE9A970F4B9FEF2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y050</accession>
    <name>A0A0D8Y050_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716236">
        <property type="protein sequence ID" value="KJH49404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y050"/>
    <dbReference type="STRING" id="29172.A0A0D8Y050"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="73"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="314" mass="35300" checksum="AB4536F988CB48CD" modified="2015-05-27" version="1">MPRLAMSIETGFVYCACCSDFVYNRVLEVMRLGAMNKYRTRLGLCKLVSWNPTDADIKAWDMMTRIGQHAQLRGLLNMGSTCYMNSVLQALVHTPVLRDYFLSDQHNCQRSPGTCLMCTMHQLMQAIQKKLYGEGCTLSEIQDFHRGDSSDPVAPSDVLHIVWEQSQMSMGGQQDAHEFFLAVHDLLHRHYSAPFSSSSVTETDSCKCIVHQTFTGKLRSDIICNKCSSISSSTQPFLDVSLIVPSNLHTDQSSIKACLEMFCAREDLDRNCEHCGCLRATRRMSFKLVFKVEVFIAIAENPSNSFSSTASIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Z0</accession>
    <name>A0A0D8Y0Z0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="14" type="ORF">DICVIV_03488</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="KN716208">
        <property type="protein sequence ID" value="KJH50360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0Z0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0Z0"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="71"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH50360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28322" checksum="40E07FC4A348D028" modified="2015-05-27" version="1">MKCGKRSKHSLDASKKKICDIEDIWKLQLEKITEMRKGGDAPVDTMGCHKLADPLASPETFRFQVLLALMLSSQTKDEVTSAAMMRLRRHGCNVDSMLDISIPDLEKLLHPVGFYKKKAVFIKKAAQILKEKHNSDVPDSLEGLCSLPGVGPKMAHLVLQIAWNKVDGIAVDTHVHRIVNRLGWMKTTTPESTRVRLQEMLPRSQWTTINPLLVGFGQKTCLPVGPKCNICLCQDICPTSTSKTSKKPRLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y189</accession>
    <name>A0A0D8Y189_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y189"/>
    <dbReference type="STRING" id="29172.A0A0D8Y189"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26216" checksum="9B0ACDFA4F886C16" modified="2015-05-27" version="1">MEARHTDTMTTSKTRGSSSHKKPSSAQSSQRRQGLVCSNCGGTNTTLWRRNAEGEPVCNACGLYYKLHNVQRPPTMKKEGQLQTRKRKAKSDGTAGSKKRDRSSNYTQSTQSITDRGQMLCHWILWWKTIHLMKKQIYFTIGTATYQPTFGSIGFSSQIDTTYSHINSYPSSWPTPGGIGTSGSDPNHSSAFHTTYPSPYPPPISKISEARQMGEEETRTATQGLVEEISERSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1A5</accession>
    <name>A0A0D8Y1A5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1A5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1A5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="21658" checksum="1657E658D13A8F85" modified="2015-05-27" version="1">MSSPSRQIKCVVVGDGTVGKTCMLISYTTDSFPVQYVPTVFDNYSAQMTLDNHTVNLGLWDTAGQEDYDRLRPLSYPQTDVFVLCFSIVSPVSFDNVATKWIPEIRQHCPDAPILLVGTKLDLRDESNPRMDGTEDRPPITKSQGQKCAQKIKAIKYLECSALTQQGLKQVFEDAVRAVINPKPLKQKKSCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1A8</accession>
    <name>A0A0D8Y1A8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1A8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1A8"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000031">
        <property type="entry name" value="PhosphoLipid PhosPhatase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF201">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="112"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="283" mass="32599" checksum="2DFD0542425D8547" modified="2015-05-27" version="1">MSADTIRISRIACDFLILAVCAIPLLIFHEWVTPYKRGFYCDDETIRYPYRDSTVSRHMLIVVGLLVPTILIVGTEIFRATAWERKCASQFKTYHLKHYSVHRLIVRLYCFIGYFFLGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYLECKNPDLYITNFTCTGSNKNLIQESQLSFYSGHSAFSFYGAWFTSLYLQARLYRPLFSRLLLPVIQFSLFGGASYVALTRVSDYKHHWSDVLVGAIVGSTIGIFVALYVAEVFKRREIPSCGLDSNEFGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1U2</accession>
    <name>A0A0D8Y1U2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_03175</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1U2"/>
    <dbReference type="MEROPS" id="M12.310"/>
    <dbReference type="OrthoDB" id="5829157at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF793">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="16"/>
            <end position="554"/>
        </location>
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        <location>
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        </location>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH50655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="554" mass="62238" checksum="CEA37F3FE3A9C99D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y231</accession>
    <name>A0A0D8Y231_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">DICVIV_03086</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005859">
        <property type="term" value="C:muscle myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
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            <dbReference type="EMBL" id="KJH50740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20035" checksum="E5CE2B290B513496" modified="2015-05-27" version="1">MPSQDQLKEIFNLYDEELDGKIDGTQIGDVVRAAGLKPTNAMVVKASGQEFKRKGEKRLTFEEWLPIFEQLSKEKANRLLACCNKREELWSDVHIESIEIEEQGTYADFVEGLKVFDKEECGKILAAELRHILLALGERLSADEVDELLKGVEDSEGQVKYEDFIKKVLAGPFPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y2E8_DICVI</name>
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        <submittedName>
            <fullName evidence="8">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716195">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12223" checksum="197BC47D97BB5C3B" modified="2015-05-27" version="1">MFVSAFELTIKALTAHIRSVHTNVRPYVCDTCGKAFVRRNDLKMHSLTHTSETAFHCKCGSKFRRMIYLKKHQRLCVLRNGKSPVGDSADQLDESNEIVDDSDDHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2X8</accession>
    <name>A0A0D8Y2X8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716203">
        <property type="protein sequence ID" value="KJH50532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="264" mass="30068" checksum="621E8CD081EC12D1" modified="2015-05-27" version="1">METGDRDGIVNMLTQVFLRADINLEAFADLIIAQSPFGMVIGPAEDQSDEDDANVVYGLLTVVPLSNDLDNPSKLSKELLDFLEKKSQKFALKEFRNAFDIAKTERTGLFINERMLNFPHQIVKPSFSSIRSDLAQLDKPYQKIVYVHKLRIAKQDAEVNVIKNEQTKSKKKMGKAEKKRLAISCLSNADIVFDNVEDEVLYKTDEGEAHFYDIPVHSEVDSSSKFHILIKDGKSYMPYRRVVIMNMKRFNAFLEQVINGDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y342</accession>
    <name>A0A0D8Y342_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Dihydropyridine sensitive L-type calcium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="28941" checksum="566D05FBD23A7927" modified="2015-05-27" version="1">MDRADLGGIAKTFMKKVKLLFKLVEVFGGGDRTDVGLIPLPIRTKHLSPRRAKEVEVWEHPNVYTVVPSTRPIVLLGPCYKTSRLTQLMHTALRSAIVKNFGSRIRRLSSDIGDKSSSKLSYDINERELRTITAMAEDLHLIFLECPNIDTPADVAQLDLAPMLFLIRISDRKILLRLLKKTGIKGANATAGSDVLNQITADQVDLIVEENGLPEATKKIFKHLEAYWLALHPKTSILEDEYLEGNELATTSSKTNQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4C2</accession>
    <name>A0A0D8Y4C2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative zinc finger in N-recognin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4C2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4C2"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="377" mass="42703" checksum="EA54A12DBB252F6F" modified="2015-05-27" version="1">MAEYNGNLLDDIDSKKEESIGQSSHVSSKPNVHGEQNSQNDGETDELLTIQDILDIEEFSKESARVLYGAQDSTVCTYPEGYKPRQTLFACLTCASNPEVNEAGVCYGCSVHCHDGHNIIELFTKRRFRCDCGNSKFTCKCTLFEEKDASNKDNTYNQNFAGLFCVCKKTFPCEVNENMHQCVICEDWFHLSHLDEKCAMLAEEREKSGQADFTLLCKNCSSRLPFLSRLSICGVDDGVLCLSAHAEFKEGPFLLTDGFRKRLCRCQNCLVLYEKSGCEYLIDSDDDIEEFTKENIEKTKDEKEPDDDTIVNELVQTAGREAAIHALEAFNDLKRNLQDFFCEMHDEGVDVITAEHVKSFFDKIKRSRIEDNTGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5N8</accession>
    <name>A0A0D8Y5N8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5N8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5N8"/>
    <dbReference type="OrthoDB" id="5854820at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="452" mass="51066" checksum="B794DD7EBE7A5486" modified="2015-05-27" version="1">MIVIAVLAGEIIRAGNEISHRTHAPSIEVSMRPWLISALEFILPYVLDNYRQKSHPLFFIHVNFRYVNVSIARSAVDLIYSIVSKEVRSFYDDVDLCCPSKWRLELSADHGDNLHNLLLGEESNTDMSFSRSEVWMLAAALGAEILVTNSLSCSIPPDSAAEKTISSFINAENIDAHDIPALFSDISNITIKVFRKYEKNFKRRLEHVYTNGGEELRRSIYEGLSHLASVSLLTTSLNPPTDYSHLPDNSILRAVIDLFSTNSACTKEALHDLLPVLVNQVRSDGRNLPPLDLQSVLSAVDYRHDSEARLNLLLLAIQQREEYMIYELTRPQYLNSNSSNPFPYLLCISQNLSAFLAILPRSRLKVILDHLLEFSIQNEDKGREILEHVDECGTNEIVFDALLRNAPSFDSPTDLLHTMTSLKSIDERFKGRVSAYVEIVYALQIAKQFATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6J5</accession>
    <name>A0A0D8Y6J5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13367" checksum="B65D1559B657D4C9" modified="2015-05-27" version="1">MWEPSFVENVLYLADSYKKHGGHLPLRIKAIPEGCVVPTKNVLFTIENTDPAVPWLTNWFETLLVQTWYPMTVCTISRGYKQQIARYLHATSDSLDSLPFKLHDFGYRGSTSVEACD</sequence>
</entry>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5794962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="285"/>
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        <location>
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            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31791" checksum="6B50BDDCEC6CC4B9" modified="2015-05-27" version="1">MRLVLFLVAINFLHAISTIPYSIYLTVSWDPVYINMNPYIIIISGAPFIFQLKVDLTLTISLAMERIMVRHCTMIISIFYSLTQLIKIFQALFFPAAFRRMSSSSYPTCCLLLGISLGTIDLILQFSLTSFRYVPNCAALGCFLDPTFLSYWGISNMIMGIVVIILTISIAFKLRVIGQQPQPNGQLGFNENKFKQANRICAGVLIISLMCVTIPSLIVGIIEMIVTSTFSIFGPFYIAGLLCAGTFDGILYVIFNKDMRNSASDVFFRKRALPVTNVSTTKLTA</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716162">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11472" checksum="2DEAEE9182D499F8" modified="2015-05-27" version="1">MDIVMNEEEETINIQIFVPEIQVRKCLTVSLDDFVWDLKRKLLATLPQALPQAFNYGLFLPPCDGRAGKFLLEDRIVRDYPFHDCVPYLEVILSNCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y739</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="14009" checksum="DC673ACCFB74B29C" modified="2015-05-27" version="1">MTQHLSLSEENERVLSPSLFSPLVLNPAVLSPFILSPAVGNPFILSPYILTPYILSPLVMAPFILNPYVLSPNVINPYVLSPLILSPLVLCPDLISPMILGGPILSPGVLSPTILSKSYFMASVLSPTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7N8</accession>
    <name>A0A0D8Y7N8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_01657</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="516" mass="58787" checksum="9FB6DEAFA552E832" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8K8</accession>
    <name>A0A0D8Y8K8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716167">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="399" mass="45081" checksum="6EF8361C20F1923E" modified="2015-05-27" version="1">MIIIRSSSSSSRRAAQLFRSATHPKKFSYIEQLTNYLKNNVIVHEPDITSFQLFIPGRFIIIPKPYGISCVGVRQQQSGVFEDSVFDRKDSDTESLKNIADDCVTISDCIPGLSRLFSEPNLSFCTGLKSKLVSERFIIFFCFLFYRYLSGAIVLPANKIDFENMKKSIQHVTGKPANCPYHYRSLAILISSPPTTLGTISGYATFQSNGHQSEYIFVEKYAKKRARTGKFAVAGSMDWRVLVERNGCSLVEFGVNKFARHLPRVMFSHMLCPILGDEIYGNRLIEIDGKPATVQPKDLRRVQHQRYFPPAVPQLLGVSQPDLIKAMPIYCHVYSTIFPRFGWILGRPKGQQDVADLYANAPPPPHFLAMVEALGMNKALMEFFHDDEEAKIIAGDKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8T3</accession>
    <name>A0A0D8Y8T3_DICVI</name>
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        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_00539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8T3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8T3"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH53228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11585" checksum="5991D7EB6985614A" modified="2015-05-27" version="1">MDQLLDIEALKKLTPEQQQQVIAGVKQQAALANAQNLITDLSEKCTQKCISSPGSSLSKSDRQCLQRCMDRFMDSWNLVSQTLQRRLQEELASTGTLHSGTNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y997</accession>
    <name>A0A0D8Y997_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y997"/>
    <dbReference type="STRING" id="29172.A0A0D8Y997"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="563" mass="63868" checksum="F1D2BF66CA931A5C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9U2</accession>
    <name>A0A0D8Y9U2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyroglutamyl-peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9U2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9U2"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010381">
        <property type="entry name" value="PgaPase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06162">
        <property type="entry name" value="PgaPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
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    </dbReference>
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        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22067" checksum="A4EE59390065FBCD" modified="2015-05-27" version="1">MAPTDVVVVTGFGPFSSFEENPSSQVVDELAKTKIPGFDGQLVVEKMSVAYSEVEEKVKSLWTRYSPKLVVHIGAHPIHHHIKLEQQSFGRGYCKYDVDGCVPQNNMCPTNSEPILSTKINCEEIASKVSQELGYKGLKITASDDPGRYLCAYSFYLSLSHDASRSLFIHVPPFDSTCTLEMVTAVVQKTITTILSTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9V8</accession>
    <name>A0A0D8Y9V8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9V8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9V8"/>
    <dbReference type="OrthoDB" id="5876344at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336335" evidence="2">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="248" mass="27266" checksum="6CFCC85B47D73060" modified="2015-05-27" version="1">MRHDCGGSRLLHVLLSVLTLVQYVLGQDSLSQLLSNLDDSRQCGRAISAGRLLSTAVNARFPRLILLARFFAEHPGDFDATFLENSSFDLRPPFKANLTGHNPLYALEYSCENATKRWLPTIVFPTKNTNSTTGRAFLTLRMGFDLDLCSAIQCSTKCTWTVHGGLKVLAKSCCGRGEDTALCRTDVDRNRPVLLVANAACAAACLALIPVVCRARRRGQEARGWALMELFLIGASILYMITYPPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Z2</accession>
    <name>A0A0D8Y9Z2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vinculin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Z2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9Z2"/>
    <dbReference type="OrthoDB" id="6376697at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="855" mass="95456" checksum="D9A8EB18FA5B12EB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Z8</accession>
    <name>A0A0D8Y9Z8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Z8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9Z8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="27495" checksum="30434C5A1B81068E" modified="2015-05-27" version="1">MVILKLFSKRALKSIPYAAILRTPAIWAVWIASIGNFTCVNMMFLFSPKYLSSVLGFPVHKTGITAALPPLAQFLSKLFFGMLSDRIKFISERNKFRIFNSFAFFGSTLFLLVLAFMGDTYKNLNMLILGCAAGILGATTGGFFKAGPVMSRQYSHFVTGNISLGITITMLIVPFIVNCLTPNQTQDEWKWVFIIVAIVLFVTNIIFIVFIKGEPCEWTKDEFVRSRTSISIKVMDLPPPSVQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAA1</accession>
    <name>A0A0D8YAA1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAA1"/>
    <dbReference type="OrthoDB" id="5818094at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9883" checksum="4429DD2707CBE9F7" modified="2015-05-27" version="1">MAYKNSENVAFHFPLTCRKTKDNDGTMLTNWRVEYGDSNPKEFPCLSALVRYYQVFSYYDIRTGTIEAFPIWTNSNDDRVIVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB14</accession>
    <name>A0A0D8YB14_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB14"/>
    <dbReference type="STRING" id="29172.A0A0D8YB14"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="337" mass="35613" checksum="C2B39620F138E44F" modified="2015-05-27" version="1">MIGNLEDAGHQFRCNIATRYIESYEYFELNCLKHERLALYVKVFAASAGNHAQAIAIHGNRLGIKITVVMPRFAPLMKISKCKDLGADVIVEGKDISESRQVALRLAKERGGKYINGYDHIDVLAGAGTVAEEIFDQVDDVDAILVPAGGGGLIAGVCVAAKALSPKTKVIGLVPETCPSLLNSLEAGKPVFTKCSATLADGLAVPLVGCNAFHSLKSIVHNVIAVKETDIALAILRLLESEKVIAEGAGAIGPAALFAGCLPELVGKKVVCIISGGNIDSTVLGRCIEKGLAIDHRLIDIDVLVSDRPGGGAELLKIIADMGASMKDMTWVIFYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBV3</accession>
    <name>A0A0D8YBV3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBV3"/>
    <dbReference type="OrthoDB" id="5874762at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336501" evidence="1">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="223" mass="24474" checksum="B433D6B90A53E978" modified="2015-05-27" version="1">MMTGRCFSAKMLMIPFLISTIIVNVINACGRTPPGHEKILNFTIDRFTIPSAMAYTSTSSVAAQVPRISRSLADAVKVVEDLILNAMDDEIVEEGRKAGLTNNLIMVVLDQLIVTVSYTPLKCDVVFLNNGLLSDRARMTNCFIIDDTVTALCDRQSCSISPPSSISPIPLQYLEIFVSLKISNAAMASWTSRLWRTLLNRATRSLSSGPYGEDFRTASVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5N2</accession>
    <name>A0A0D8X5N2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719898">
        <property type="protein sequence ID" value="KJH39840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5N2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="15162" checksum="4FECC146C48CAAFA" modified="2015-05-27" version="1">MKRRFTGIPVQRTFNGMPLQNGWMTPSPLCSPPTPLCSDASPLFQYTLNNRFSPYGQVVDPLPVLPVDEVERILRDIENEPQKPVKRARKKRETSTKKKSPPQSSPSALQIQKITRRQITSKRRHLTERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5T3</accession>
    <name>A0A0D8X5T3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">40S ribosomal protein S24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_14261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719872">
        <property type="protein sequence ID" value="KJH39843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5T3"/>
    <dbReference type="STRING" id="29172.A0A0D8X5T3"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH39843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13258" checksum="2C9AC8E4B2951163" modified="2015-05-27" version="1">MITAGFFVKVVEVLHPGRATVPKTDIREKIAKMYKTTPDVVIPFGFRSAIGGGKTKGFALIYDTPDYAKKFEPKHRLIRMGLMKKVDRGGRKQRKERRNRQKKVRGIKKATVSAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7J2</accession>
    <name>A0A0D8X7J2_DICVI</name>
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        <submittedName>
            <fullName evidence="1">VWA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717148">
        <property type="protein sequence ID" value="KJH40520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7J2"/>
    <dbReference type="STRING" id="29172.A0A0D8X7J2"/>
    <dbReference type="OrthoDB" id="5792707at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF65">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="458" mass="53168" checksum="F09BE61B808DBB4F" modified="2015-05-27" version="1" fragment="single">MFLATKAQKLLLLGIEQLKIFIVFECHAAVNNSRNHAQRQRTRPLSFKEIRHKGCSSMLCRFARIESNIIYQQPEQQWHHSSKKKVEKTFQLNSRKFACSTVIRINERQKAKKDNISEELTVNSWELHKLNSKMETAHHHFLDPDFNGMAMALHRFLICLQLGITVSTEDFGLEKFSQILISQFEEQSRAKLLDEPFEQLKSKLQVQLEDPRSALDSAKQKLEQLFSDRSKALQSDKAHPIRYVAEVSVFCTLSCPRDWMISHSWITRSKLVGIRIDPPQLRTQAIASNSRVLTTRAACENDSNDYGWKIKFLIKLARSAEGSARYYAVYNDAQFTMPRDKSFCSEFERMLNDSDVKTVSNSASRTSGVHVSIEAYRCDPKVIRDFSWTGAENIEKTMAENERTYETMRHQFIGTYSGVTRMYPRRYWRVEPAPITIDLFDPKFRPWFVNAESAPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X826</accession>
    <name>A0A0D8X826_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_13346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717049">
        <property type="protein sequence ID" value="KJH40693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X826"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="31193" checksum="305842564E655EFF" modified="2015-05-27" version="1">MFRTIVGRAVASAAGLQFCATAICLSDKELSKKPKWYQKDVLELETSLKTLGRRGFTDSPTVLSEAFDTLKKFSDFSNVEVQWRLARACVEKSVFSKCVKEKTNLLHEAVEYAKKAFALDLDNHCAGAHKCKGVFKHAIFMYAIALSMLQDIDKKADRTADIIKHFELASEIDSNDAYTCHLLGVVHYRKKNYEEALSLFEKAEKIKEKFSVRNLYYMGLTLQDTGKTKEAIRSYIAAYKLRPSSEYDIMARSQAKAKLLKLNVSKEEYEEGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8U0</accession>
    <name>A0A0D8X8U0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716946">
        <property type="protein sequence ID" value="KJH40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8U0"/>
    <dbReference type="STRING" id="29172.A0A0D8X8U0"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF19">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="286" mass="32877" checksum="679EB94C86E038B8" modified="2015-05-27" version="1">MEEAFEYFVRKETIMAASKTMGHLMLNNNRNGYRAIPQDAMAKLLQSSTCFDALPLSQNVLILDEDLLMWEGFRRILASELVARAKKRKTLVWLSAEDSLLEAVRMLAKYQVHRIPIFNPLSFDPIGIVTYKCILKFLWRYGNELFQQNIFTKTPKELCIGTWKGIRVVFPETPLTDCFDILLNLRISAVPVVEPITLRVVDMYSRFDAVNIALQNEGFKIRKNVRQALECKYLCATVVCCCHSSNEDVVDLLHILIEEEFGCDIALFRLSEMFRAHISLKQVGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X940</accession>
    <name>A0A0D8X940_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717451">
        <property type="protein sequence ID" value="KJH40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X940"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="286" mass="33141" checksum="D21D3CDFF76DD9C0" modified="2015-05-27" version="1">MMNDDWQSENIFIKQELHEVENGRNVMEELKRAVRNTIARVMTFNPAGEKVKVNQSLLCEVVTEVMTIMSERFGPMWYNLAAAQYATHVQNVDNGTCEDMHQVSQQQDNECQQPQAFNPQPEPHQEPHQQRHQELHQEPQQQPSHSQPENLIQQQLSFDQNLMNALYTQAFFQAQLLLNNLAQTPLPMNATNAEQFVPKLESFNMSEPQRNIFNPCDPMMDLTPLPMPPELSSLPMSSLPPDLWPYKNHCKLSVPTASQQPIFLVYLTDNVVWFQNHLYNVTKHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X958</accession>
    <name>A0A0D8X958_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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    </evidence>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10646" checksum="0FF3FE7E0DEFA3B5" modified="2015-05-27" version="1">MPSENEEVPANLIATGFYWNRKQFTTYLDVIIADDPKTAKLQAVNLTLNNTTEYDEVETLDRAPCHGDSGGSLFKADNGKYILLGIHISKCSVPKK</sequence>
</entry>
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    <name>A0A0D8X9A4_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
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        <source>
            <dbReference type="RuleBase" id="RU004379"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717455">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="59" mass="6761" checksum="F3F3E6C3329EB5AF" modified="2015-05-27" version="1">MTELLHYQQHSDEHLREDDNAIMANWSTQIWQNILNRVMRSLSSGAFSTNLIGATVMIA</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716826">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="439808at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="19420" checksum="0CCCF3512BCCE02E" modified="2015-05-27" version="1">MGLANGSFTSIYFSEAKVIRDSQTQKSKGYGFVSYPIKENAEKAISAMNGHWLGRRAIRTNWATRRPAEECREKLTFEQVFNSTKPDNTSVYVGNVNPNTTENDLRDSFSVHGEITEVRLFKSQGYAFVRYERKECATNAIMDMNGKEIGGNTIRCSWGRMQQVSFISIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAY8</accession>
    <name>A0A0D8XAY8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_12255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KN716764">
        <property type="protein sequence ID" value="KJH41765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAY8"/>
    <dbReference type="STRING" id="29172.A0A0D8XAY8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000209">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF32">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="207"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH41765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49316" checksum="AA29BB05FDFA8031" modified="2015-05-27" version="1">MSSLCFQILKKFDISNDDLHIISCKIEAEMKAGLASVGGSSIAMLPSYVPALPDGSEEGQYVAIDLSGKNLRIMLLTLKGTDREPTAVNNNYIVPNHVMKGTGDQLFTFIVNCLQRFLQEFGLVEANLPIGFVFSYPCELLSIRSARLLWWTKGFDIKDCLQKDVVQLLEEALEMNMSTKAQIKAVMNDTVGQLAAASHKYGPECTIGVVIGYGCNSSYLEKTSRITKFNANAVGYKHPNMVVVTEWEEFGSKGELDAILTDFDREIDAASVHKGKQIIDKLTGALYLGELVRRVLSQLVLDRVLFDGHPCEKLDEVDTFPTKYISEILAEEENSYKACRRICDELDVPMHGSGDYHIIHDVCFAVSNRSAAIVATAISALLRHLDVTKVKIGVGGALIQFHPIYHKLLQDKLADLAPLSTEWELVPADEGSARGAALIAAVAEKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB13</accession>
    <name>A0A0D8XB13_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate-CoA ligase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KN716764">
        <property type="protein sequence ID" value="KJH41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB13"/>
    <dbReference type="STRING" id="29172.A0A0D8XB13"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
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    </dbReference>
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            <begin position="236"/>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41763.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="360" mass="38685" checksum="F5B83AA83AB34AE9" modified="2015-05-27" version="1">MKTNGDDTEYVVKAQILAGGRGKGHFINGRADIDDTEYVVKAQILAGGRGKGHFINGRADIGGVFITLNRSEAVKAVDDMVGKNLVTKQTSKNGVKVKKVMVAEGVAIKRETYVAVLMDQQSNGPVVVASPAGGMDIEQVAEMTPNLIFKVAKEIKRLYDLFIAVDATQIEINPFAETEDGRVFCIDAKMNFDDSAAFRQKDVFAMEDCSEQDAREVEANQYRLNYIGLEGNIACLVNGAGLAMATMDIIKLKGGEPANFLDVGGSVTEDQVFHAFRIITTDTRVKCVLVNIFGGIVNCVTIANGVVSACRKVNLKVPLVVRLEGTNVDEARRILIQSGLPIIAAQNLSDAAEKAVAALS</sequence>
</entry>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716721">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBR3"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6796" checksum="96F2529EDDD156FD" modified="2015-05-27" version="1">MLPKMLHLLSLAKRRPRLLRAYLIRIVSTYLLPLCVRLVKNFVFSLIRMQPANYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBW4</accession>
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        <name evidence="7" type="ORF">DICVIV_12871</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBW4"/>
    <dbReference type="OrthoDB" id="2016263at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="523" mass="60112" checksum="4F5BDFC869852575" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8XCQ1</accession>
    <name>A0A0D8XCQ1_DICVI</name>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716670">
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        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8378" checksum="403092315B766191" modified="2015-05-27" version="1">MSFYVYPLRVGHAPRSIPRVRRVPLFEDEEYRELIVDVYDDSEFPLLGTRSESDNDINGKSRDLMARSDGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCR6</accession>
    <name>A0A0D8XCR6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper type II ascorbate-dependent monooxygenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716670">
        <property type="protein sequence ID" value="KJH42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XCR6"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25760" checksum="E87060BF21A21150" modified="2015-05-27" version="1">MKPFSHQLHRSAHLPEQGIYIFGSQLHAHLTGRKIFSSHYRYGVKIGEINRDDHYSPHWQHIVHLNPYIHVVPGDVISTTCIYETLSRDSVTLLIDVREGGYGIEDEMCVNYIYYFPVSEVEVCKSAVDNASLHRHFHNKYDIRQTSLPIYQKYASVNWNEKNTLLLKELFAVAPLNINCLKHDGLPFPNHPLNWTGVPQPRVRMTPFTKQRDRNECPALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCS1</accession>
    <name>A0A0D8XCS1_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716670">
        <property type="protein sequence ID" value="KJH42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCS1"/>
    <dbReference type="STRING" id="29172.A0A0D8XCS1"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="18259" checksum="57E31D4C8B28C972" modified="2015-05-27" version="1">MTTSKYADFLTSFLTNYPGETTSSSPQPPTLVIPQTTIPLWMVATTKPSFHGQHEINEGNRKNEDKIVSDLEREDEHDKGVNKVSKTAIIEAGGQKTSAVNWIVAAIAVIVLLLILLATIVFVLRYVKQSRKLHGKYNPAREEHALSAAYSMPMSHISKEERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD80</accession>
    <name>A0A0D8XD80_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717278">
        <property type="protein sequence ID" value="KJH40376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD80"/>
    <dbReference type="OrthoDB" id="5869010at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15503" checksum="DE55267860A3A851" modified="2015-05-27" version="1">MVSAANDTNNSINNRNIPSYAKNPSVSSQTTPKLIEDNSTYKFYIIIFSLLLLFVLIALSICIAILVRKVKRRQKFNENGFPNPPWRLETSSQLILLEWVKVIVTKNPLVWRCSDREIIWLYDKRHPACMPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XED1</accession>
    <name>A0A0D8XED1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716602">
        <property type="protein sequence ID" value="KJH43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XED1"/>
    <dbReference type="STRING" id="29172.A0A0D8XED1"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000111">
        <property type="entry name" value="synaptotagmin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF221">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="15"/>
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        <location>
            <begin position="157"/>
            <end position="290"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="298" mass="34470" checksum="5A15D668FF4EEAB8" modified="2015-05-27" version="1">MSLSKKKEEEKEKKFLGRLSYKLDYDFDKNAFLVLKNVFKYYYFQLTVVIVQAEELPAMDLGGTSDPYVKLYLLPDKKKKFQTKVQRKSLNPVFNESFTFKIPYNEIGGQTLVMNVFDFDRFGKHDQIGQISVPLGKIDLATTIEKTDLIESPPENRLGEVCVALRYVPNKNKLSVVVMECKNLKKMDVLGLSDPYVKIYLMLQNKRLEKKKTTIKMKTLNPYYNESFSFDVTPEKMQRVHLHITVSDYDRVGSNERIGQVIIGPNASGIALKQWTDMLATPRRSVAQWHTLLPFNDD</sequence>
</entry>
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    <accession>A0A0D8XER6</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KJH43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="63" mass="6957" checksum="F7F44459719E3E17" modified="2015-05-27" version="1">MTYKDEIKSAPYQVTPELSSLPGLRPISLPLYMTVGSFFTTPDIVFVISQSIKYVGAMALTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF59</accession>
    <name>A0A0D8XF59_DICVI</name>
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            <fullName evidence="9">Plexin repeat-containing domain protein</fullName>
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        <name evidence="7" type="ORF">DICVIV_11685</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XF59"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38029" checksum="AA0BFAD2AD6D1FA5" modified="2015-05-27" version="1">MTIYANRSEQMGMYWVDLDSLLKTPGVVGNTSHPLLTGSYRRAVGAKLSFKFPFYGHMMTNLTIATGGFLYVGDQTHNWLAATQYIAPLMANFDTMLDGSSILYADDGEKFVVEWRKVQLREQHQAGAFTFQVSLFKNGSIAFVYKKVPMNVSSISDEQHPVKCGISDAYLYHHMLMTQGISGFYFILTSPKRVIYEYHRIEIPLEKVAADTVVYLDAQPASLFFLCRSIHRRRQHWAENNCKNQGKNMYCNAAVDEEEVENDGPTSSSERPSPDDVIPLTKGRPSDKTKGKTEGGGYAALVFTLGSSLCLIGWLAYAYYNPHTTSGQLLIKYSSLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF60</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="254" mass="29350" checksum="BCFE89F6EA9A30A9" modified="2015-05-27" version="1">MKSLRFSRFRGPKILTKLGVRIIFLQCLAAPGIALIASFLLGSIIHPSNFYNYKWTCGTVHLPSISRIMNMPMERTIFHLLILTTVPLRLIVLFKHWLVFYVLNSSWMVLVTKRLLVLFGFGEVLFLSLLTVIGERENGSVHVVLFSIFVAFSYFYFCTLHLLSKWTHKRSDSEQRTIKLQLICLTAVTFTIPLIFLLFIFHNVFCIPGSYELFALFEYITLAAIYGFHASSLKMMSGMIYVYHTSIKLRSIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFQ3</accession>
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    <protein>
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    <organism evidence="3 4">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716560">
        <property type="protein sequence ID" value="KJH43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFQ3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
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        <location>
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            <end position="105"/>
        </location>
    </feature>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="187" mass="20499" checksum="6FC31C07E359B3BC" modified="2015-05-27" version="1">MSILDAFLHSFPAAFVLAFLTPICGKSKNFKNKDSASARKDSDSDLKTAVLNPKIPQKPSKKPNNHLDQKKTDVSPKKDQNSKQQSSAVSNKKVKSTKKQTDVDDTIGDAPSLPVAIKKFMKVFKFLKNISTPTVDSLHNLKNVISDVATAKPNQFLMDDIHLHGTQTLDTAAETQVVSTLRQPTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="432" mass="49457" checksum="84FEFE82556B3A01" modified="2015-05-27" version="1">MRLHVCFVQFDGVNSIAWLGTSILPIAGRCSGFLSVNCKTAYSQWYTSMVDRYSPIVAACLKDSSTLVRQQTLQSLTSLIKEQFIRWEGQIMYRFVSTILDENKVIRDYTKFCLRDVLLPQFPGLFSNHFIECLMYFNKAPGACEAKGVQQSIDPAQHVSLHSSSNFENRMTIYKFMLSTFDDRLKFTLMAHICTQVICPIMNGKLKYDDPCVYDLLKDSLTIMSLKEMKLNMEVGRGPDEEDEPPAAVVAAAKEMITQIFRKAMIEYVMPALLDLRVYLAEKRSRLRSELYTVFRAICRENKDMIDEFLDGDQQLRAEVEYDIRRYELRLKAKWADAKRRAEQSAVKRRLSRRSLAVVIETEEGNKTLGGSSKNGTTHVEPNGETDKSAPSVDPISRSGFQKQDISISWKSTVSSRIRFVLAVIYLNCYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XFX4_DICVI</name>
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            <fullName evidence="2">ADP-ribosylation factor-like protein 6</fullName>
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    </gene>
    <organism evidence="9 10">
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716546">
        <property type="protein sequence ID" value="KJH43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADP-ribosylation factor D"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="16965" checksum="4CD5A1CA73128CE3" modified="2015-05-27" version="1">MGLLTILRKQREREREIRVLILGLDNAGKTTITKKFLGEDLSSVEPTLGFNIKTVEFQGFTINFWDVGGQKSLRSYWRNYFEQTDALIWVVDSGDEERLFLCRDELKSLLNEERLLGASLLVLANKQDLHSAMRAADIAKVTTVCFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG89</accession>
    <name>A0A0D8XG89_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG89"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="18220" checksum="E7001EA1C5496B97" modified="2015-05-27" version="1">MVRTSFSCIRRMRSRPFSAYSNLCEIEENDEIVESELGYWHSKSEENEEFEVIEIRKEVGHPGGLAFRIIGSRTSGIFVSYVDETSQQARQMIKVASIINEGDLIKECNGRSMSGYTCYQAASILRHTLSNFGKLRLQISRRSCGSLLMSKRRCHIVNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH67</accession>
    <name>A0A0D8XH67_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716513">
        <property type="protein sequence ID" value="KJH43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH67"/>
    <dbReference type="STRING" id="29172.A0A0D8XH67"/>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="23476" checksum="A605183844B53314" modified="2015-05-27" version="1">MYRLYLIKCMENKRIEKCNQFFLKCVVLTQNNPVWTEWFTFPYHPNPQGCQTFRKYYSNEWREVFVISLHNFVRMAIQLAPKSHLMQLVELLSEDMGASSFCGRALTVANCAVDDELIDDFAVIAQLWEKCDTMSKSERFFGPKCVAFFLVKQRTPLNINSPVGSAFYNKSSVFWWSKKFNKADKDLGVLKRSGYPEVDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM9</accession>
    <name>A0A0D8XHM9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716580">
        <property type="protein sequence ID" value="KJH43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHM9"/>
    <dbReference type="STRING" id="29172.A0A0D8XHM9"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF125">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG CG6966-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="424" mass="46691" checksum="0EC70DED415507B3" modified="2015-05-27" version="1">MSQPTPSRLYIESASAHPISFPFTAKEANQRGPYGRTPLMMLAKNTVKTEEQLINDVTKLCDIGADINLLDDCEWIIQEFCGHLSRTFFKVNAVDNSNRTALMLVAMHDRVDTKAAKMLIEAGAKVDYDGDNTLTSWRGRTALHFAAKYDNAQMVAFLLQMMANENCQDYEYCTPLHLAAAEGHIGPVKELLKGGANVLLRNDRYQTPYDIALLNNCHSVAALLASSDNLRVQLYSNHGEMLASSSPPCFKHVKILSSNIKPPRAHVTYESKGCTQSTTAADESASVFSPYNYIITPYSAAVCGTTTPSELSSVKSAQMVSSGCTTHSVHYITPYVQRFDDSRIDPGSILSSPHYEEVEKCCMKSEKQMGKSSGFFDSGFGISSDISSKRDSIAPCHTFDRFLIPKDCVDACSKPFVSSQEFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI44</accession>
    <name>A0A0D8XI44_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAP3K deoxyribohydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716724">
        <property type="protein sequence ID" value="KJH42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI44"/>
    <dbReference type="STRING" id="29172.A0A0D8XI44"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAP3K deoxyribohydrolase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="189" mass="21203" checksum="5CBA24FC7252A83F" modified="2015-05-27" version="1">MKLSDVNIEVCPISLSSRSTLGRTGSPSFQRTPQSPGSNTDKMGPNFTRKLQVVIVIDQKVQKNLRVREMALKDVQNVADTLNVNLTQIDFDRLDFGEANALDTFYNADVALVDVTVQQQQPSLCYHIDCSHRFTNITLHHPANELLLVYHFFFVGPQSDGAHRERYIAGAFLVIGKNNLDYPAIPFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIG2</accession>
    <name>A0A0D8XIG2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716478">
        <property type="protein sequence ID" value="KJH44383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIG2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13465" checksum="FD6DFEB0C9939B76" modified="2015-05-27" version="1">MSVVYKETMIYSKKKSFLRKGGNIPMIFKGLSIPVVTIQGYSKSFLALVYQLRTPLSIMTPLALARVRLYLLGLFEEKRLVAVDDYGNRMPTPDMKQRSKAKCRQFQNDVKIISRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIK5</accession>
    <name>A0A0D8XIK5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716469">
        <property type="protein sequence ID" value="KJH44485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIK5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="20757" checksum="135608FA9813E52D" modified="2015-05-27" version="1">MALYVLDFINSNELLDEIEEICKELLTLNDQLPHVLYECHRKTTLDAVNLLKVHYSSLLVNLIKLRVDVNQILIRQQQWQKRTPNELYDDRDDDVTDLNVTSPSRSINWDIMESMDNDVPLNDTVMETVRKGRRRSRSLSFVKKIIRRFSRSRTPRCRLTINIDNNNADVTLRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIM6</accession>
    <name>A0A0D8XIM6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calcium-binding carrier protein Aralar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_09527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716473">
        <property type="protein sequence ID" value="KJH44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIM6"/>
    <dbReference type="STRING" id="29172.A0A0D8XIM6"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000396">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="367"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="465"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="557"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="706" mass="78949" checksum="1A4E56CAC87618E7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ14</accession>
    <name>A0A0D8XJ14_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARF7 effector protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="ARF7 EFFECTOR PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17748" checksum="A2A6FD77A9DEA592" modified="2015-05-27" version="1">MILRPILSFSTRHMMNQRRRTISHLLLWVDRQRQMQRELEKLQFINPGGSMTQPTSNRRSRRRINEDKETVQEKRNIFHDKKGKLVVPGEESITLCDCLIPECHGCHWPCASCGSRLCGPICQQNRKKFVACVKMLGVTPEIVTNNPYVSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJN1</accession>
    <name>A0A0D8XJN1_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716652">
        <property type="protein sequence ID" value="KJH42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJN1"/>
    <dbReference type="STRING" id="29172.A0A0D8XJN1"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17399">
        <property type="entry name" value="MFS_MFSD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF30">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="455" mass="49975" checksum="681E588785B31F6D" modified="2015-05-27" version="1">MASEFHAYKRRWIYLFAVCLVNFSNGNTWITYAAITFYTNEFYGNKNAALLFCVIFMALSIPVGLLACWWTDRFGLKSAFHIGALTNFIGNAIRFAGSGVWFSKSIRFPLAFAGQTVAAFAQPFVMFLPTKLAAYWFPRDQRVIANTLSSMSNPIGIAVMYSISPLLVRDSRPAAFAILTGVCASLAAISVCFGLFVTRSVPPTPVSASRNSDIKIPSFIEGVKRCLRSKMYWVLAICLGGGVGLFNGLYNNLQPALCTMGYSASFNGGMGTLLIVSGLVGAVISGMYVDKTGKFEQTMKLAFLMAGIAACSLTISINYESVESWVTASIFFFGACGFAIYPIGLEMGVEVTFPVAETTSTGLIVMIGQIQGIIYVILTNMFVGKPNNHQLALQTCTNDDSNLNTVVTWSVPFMIWCGCVWILIILFVAFFWPNYRRRDYEAARNVMEQSVTPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJP1</accession>
    <name>A0A0D8XJP1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716651">
        <property type="protein sequence ID" value="KJH42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJP1"/>
    <dbReference type="OrthoDB" id="5868525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335892" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23264" checksum="FA90D515AD3A9FFC" modified="2015-05-27" version="1">MECLIRTPWALIMLAGGQLSSLVNCSLAIERMVALQFFVGIEVYELITVDDTVEAMAIIVGPGRGNELPSESSIALFVIIAVIHNIYDTIMNENRACSIIETTGIVYGTKPSPNQIRRQRIIDQMNINDFYRSICSTERIVKCVMFRSRSKKTVEKKKANDDENRHNSIPTFHSSFNHSTVHQYGNELMGELNARTVSTTMMTIRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKB8</accession>
    <name>A0A0D8XKB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KN716491">
        <property type="protein sequence ID" value="KJH44197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XKB8"/>
    <dbReference type="OrthoDB" id="5865511at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF285">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="15304" checksum="C9D1296084CB0BFB" modified="2015-05-27" version="1">MNFRFFTIVGPPPQNKILFLGDYVDRCKKSFEVIMLLLCYRIKYPHLIYLLRGNHECSKMNRLYGFYEEMRRKRNVYIWKKFQEVFNELPLCAVVSSRLLCMHGGISPEIQSWDALINLKVCLFLMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKG3</accession>
    <name>A0A0D8XKG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKG3"/>
    <dbReference type="STRING" id="29172.A0A0D8XKG3"/>
    <dbReference type="OrthoDB" id="5867987at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF372">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="283" mass="28039" checksum="5E8004E6FB3B3E18" modified="2015-05-27" version="1">MEEKLKLVEAESVKKFAFFGVAVSTVATLTAIVAVPMLCMYMQNVQSGLQDEINFCRTRAEGLRGEYTKLESFRTVESREKRQTYQCCSCGMGPAGPVGNPGQDGAPGNDGRPGAPGAPGPDAPNDHVVPRPEDFCFECPPGPAGAPGQPGPKGPPGNPGAPGEQGPNGRPGSPGAPGPQGPPGPNGNDGQPGQPGAPGQVRTVPSPPGPPGQPGEPGPPGPPGPDGRPGNPGTPGAPGPQGDPGQDGAPGNPGAPGEPGAPGKDGLKGSCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLV2</accession>
    <name>A0A0D8XLV2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716454">
        <property type="protein sequence ID" value="KJH44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLV2"/>
    <dbReference type="STRING" id="29172.A0A0D8XLV2"/>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052792">
        <property type="entry name" value="Thioredoxin_dom-contain_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="102659" checksum="8E66C69B0D21C9FC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM20</accession>
    <name>A0A0D8XM20_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7 18">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_09122</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7 18"/>
    <dbReference type="EMBL" id="KN716444">
        <property type="protein sequence ID" value="KJH44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM20"/>
    <dbReference type="STRING" id="29172.A0A0D8XM20"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
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    </dbReference>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="416" mass="47404" checksum="EDEFE3435BCBC898" modified="2015-05-27" version="1">MLLKPSSIVLEEIIEHLMEKDKEKVFTSPVTVEGYRDFIKHPMDISTMKRKLERGKYDSIAALRTDVLLMTDNCEKFNHENSYYLHYGRKFRKVALGLLDKEEYKERFLEELLSNGSEQPLLDELSRIGLYDVLEMDLVKEESEQECDVEKKSKVQTHRSRNTKDSLHLTTESKQVMGSLGLGSFLTPKPIGGRLFLINGISAKAKRKTSSAERSPYSKRRRKLAATIEKSLRQPSIAKFLSESSTTARRLTLREHCAAPLMAFRDNSVKSPLAGDVVSSESSADEEDGTNHCQVRGDHPGMNTQNQSDFDGYHHNDLVVVDGIAGRVIDPVDARVDGGLPSELVSECRMSANRRDSQICVYLFENENKWGWYPLHDVRYLNTNGDNMSSLSSFRLAMKWQKKMIDMYSSKQTMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP78</accession>
    <name>A0A0D8XP78_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716401">
        <property type="protein sequence ID" value="KJH45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP78"/>
    <dbReference type="STRING" id="29172.A0A0D8XP78"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="121" mass="13371" checksum="E5F3BEAB5F9147AD" modified="2015-05-27" version="1">MTSATKGKILAVIGDEDTVVGFLLGGVGELNKARKPNYLIVDKQTSIQEIEDAFKSFVARDDIAIILINQHIAEMIRYTVDQHTASIPAVLEIPSKEAPYDPSKDSILNRARGLFNPDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPS8</accession>
    <name>A0A0D8XPS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin motor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716347">
        <property type="protein sequence ID" value="KJH46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPS8"/>
    <dbReference type="STRING" id="29172.A0A0D8XPS8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="15288" checksum="CF9F88F7FC2F9BD7" modified="2015-05-27" version="1" fragment="single">LLLSGATGDRFKEAAKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQLLLSGATGDRFKEAAKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNTKTIMIACISPSDNNYDETLSTLRYFFVCIFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPW4</accession>
    <name>A0A0D8XPW4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716387">
        <property type="protein sequence ID" value="KJH45777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPW4"/>
    <dbReference type="STRING" id="29172.A0A0D8XPW4"/>
    <dbReference type="OrthoDB" id="5859258at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="237"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="2">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="375" mass="42749" checksum="190B05ECFE491DB5" modified="2015-05-27" version="1">MLCEVCPFGSTPLSNRCVETAVSTSSSFLEAKVHNSCSFRMLSLPYESDRLALMRLMSKSFDENETYLTSGFRRRSQWEWQDGKLIDDGNGNCLAVTNNSFRAVECNSTGLILCEIAKECLEHNEYDGMKNTTNIGRLLTGDQKCTKLSYTSCLWICCILVAKIQCYMKAVVPKSTHFKRILLETPDFKLLRIVIPVFFDALTPKNAYQMTSDAITNPIVWTVVMKRIVIYPIFICCTASSVEIEDTEDYLEEFEFIGSLKIATKIVEIWLFIPHAQVCARRCHDSLTCEAFSYENTTQARTFTCLLTDSAEIVDNLAVKHSSQFYRRQNSTKYIHFKLINGELRVSKKNTWAYVCGDGYSFEYSTSICGVFGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ92</accession>
    <name>A0A0D8XQ92_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716379">
        <property type="protein sequence ID" value="KJH45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ92"/>
    <dbReference type="OrthoDB" id="5788260at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14039" checksum="766E42A66ABE8A47" modified="2015-05-27" version="1">MPESQRRNSEFLDPRETFEHYENRSRPTSSLSFDQSVPHGVLACEYRTGLPLGSHGALACEYRATPHETRYGIDENRPATKVTTFFPESNRKKIPLGVVLAVAIGVPVVLIVSLFGAVWLQELGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQM2</accession>
    <name>A0A0D8XQM2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716334">
        <property type="protein sequence ID" value="KJH46815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQM2"/>
    <dbReference type="STRING" id="29172.A0A0D8XQM2"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="23458" checksum="6B8982E56F9EB07E" modified="2015-05-27" version="1">MLSRLISNVRLFGADGTRGRDVEMVSLGGESAFPPGSTVHFKTALGASLQAQVVCFDPALKVLAVRDTSAGKPILRMFNIALISEITEISGPANGDSLETMFSPSSMSNQQVTDRSAVAESRRCVEAMEADVTIEGQRAFIQLRRTLDDVRWIGENISVLGRVVVRPPYTPESAGAVQEADSQAQSALMHVRKILSKPFIPEQKLTACCVAHEDNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR25</accession>
    <name>A0A0D8XR25_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin family repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716448">
        <property type="protein sequence ID" value="KJH44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR25"/>
    <dbReference type="STRING" id="29172.A0A0D8XR25"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF8">
        <property type="entry name" value="PROTEIN CBG16761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="446" mass="49916" checksum="E704AE5A96AEDCE0" modified="2015-05-27" version="1">MSSMPHSTEPTIHQAGTMGEEDCRDDSRPRKRWTLEQLKCGNTFLSMQAATNKFDSQCGMTAPGMPRWNIVRDKQMGSARDSQFISVSKIMIEKIFYTLRSYIEPDRRSENILRVQCGTNQYASQKGETPMGASRFQVPKVSYKKDWETILDKEGEKIIPKQAGDYGLATQAGEVSIGAHRNQVPNVRGRLPHDRRTHGVLVFQNGTNIFASQTGMSAPPGIGAVRQATQRIEGLDMNEDQQRRGTEYTPWYSGQNKFATQAGSGGFLKVRDVIPHSVGGKDIEESLKQKSEGIVPLQSGTNKLASQRGMTGFGTPRNTIQKSGWKKEWIEEYEAALKEWEETKPPGSGSSVDPFGHYKKKYEERASSRQSEIDNQSTNANEMVEEKGNVKENETVTLNNDKEKDRTERNDEQGFITRSLATMTLVNKSNLRPGTILQSTSSSMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR51</accession>
    <name>A0A0D8XR51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716362">
        <property type="protein sequence ID" value="KJH46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR51"/>
    <dbReference type="STRING" id="29172.A0A0D8XR51"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="26954" checksum="FDB17E4B90E63AB1" modified="2015-05-27" version="1">MANRFCKGMCQAKRRKCAKILENFQLFSSHLLLIEFDEFNRGCAFDGMSQNSFSGESSESAVQRTVTISVIRDTGTKVQLMFKAHGLKKRKSLINSIVTVFKKTKYHTKPGFVVPYFVCNIQRNAPEKGDLDGILKKKCFGGSCQIRFGPSSPSRLLSNGRFTKFELKPNSLYFVLHVQRENKPIKSNHNANRTDIFVCEIKQFPTGINPDSAEFEANSGTGKWRMLHLTIIDQGRQS</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716358">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRF3"/>
    <dbReference type="Proteomes" id="UP000053766">
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            <dbReference type="EMBL" id="KJH46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="12399" checksum="B039FF21041E8ADE" modified="2015-05-27" version="1">MNRVVVLSNWKAKKLDVLTRYLRKILKDDGKKIVVYDLIWIDKPMMTITILFDSGDVIFNDARKLGRWRSDYSIDFSQIHGKRLYIENMIQFLPYLGSFFLVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS01</accession>
    <name>A0A0D8XS01_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">CNH domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="1"/>
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            <begin position="64"/>
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        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="31217" checksum="C0DA42A5B63CF504" modified="2015-05-27" version="1">MTRDLLDKVNNGSSTRLLQRTSQDEHDGDSSAEEEIIRSLCDELTIHLDGIRLGVDKCQRHEVAPSTSSSCSSNTPSSGAFHSDRTLPARDLPPLPDVVSGDALLHDGNGVIDDDKGTLIACRAAPQFLRVPKNSIRQRSSSLENSDAVRLRLLIGCEAERPKTYFGVPVTPKVSGLHCHVRLSLRKFDLNNKQVVMGACFTKMLHECSLRINCAGSWVHPSTGAQILLLGCEEGIYAVDTSKLHDGELTKIHHRRCSWLHVHQDVLMAMQGRTSYLYRWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS61</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716421">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5813795at2759"/>
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            <begin position="32"/>
            <end position="52"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34125" checksum="A9F28AAF2FE9E798" modified="2015-05-27" version="1">MRGGRRIVVDALYQSTTFSIVRNRLKYGTKRMLLIAAFLNLLLIPGSIPAIVDRNCTMNNAEGNLKFASDAVNCPNVLSDSTCNTLYPQAVDLNADRDRHNNCWMKNGAVDPELVETAVNTCPRTCGYCCITPAYNCQNKQLHIKISKFLLTFGGCSDAIAGCSRVPGICQTIGLIEFAKLVAKNLKNLNVLTFCLRSTVRKHADSVKLVRRFPLHRVRLYADHIRGNLLTYHYLSVFYEDVTSGNGTVSVQVPFIPPLKNYSIVANHVGFAEMRQNEPTSSIYLITIISTYNSYQIIIAIDFVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSF1</accession>
    <name>A0A0D8XSF1_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Methyltransferase FkbM domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_06447</name>
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    <organism evidence="3 4">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716306">
        <property type="protein sequence ID" value="KJH47460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XSF1"/>
    <dbReference type="OrthoDB" id="5867391at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
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        <property type="entry name" value="METHYLTRANSFERASE FKBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED DUF13 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="2">
        <location>
            <begin position="237"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="53927" checksum="F8E0A9A20AAD8E2D" modified="2015-05-27" version="1">MGGTGGRDSFGFLMVPYRQRVSIHQMTNHLHKQRRYPSVRIVWIFFILKENRVDNHGSQSTPVISELIDSIGSPLSYKIQKLCVFNSPHLFRNSHYRPHYGRDHDTQSNDEILTTRGVLVILIGLMVLLIYVTLSSVTFDDDTITKTVLGAFNDWRQCMIQQVDSARNEPQKMKFSPPRGVLVILIGLMVLLIYVTLSSVTFDDDTITKTVLGAFNDWRQCMIQQVDSARNEPQKLWNSFSKIVRHCTSSTDVSRINLVPLENSDEIKYFIISDDVTTPKVVVSLGIGEDIRAEQKLQKLLPNGSLFYGADPVTVTNAELFSKIGTFFPLAISRETGRYQSHIRLSNGAYEPMTVVNIDVITFFTKMVNHTYIDYLIMDNEGPEYEIVPMIVIDDSFEQNNIIPCQMNVEFHVPPPHDRYGKFATIMWKMLEVGRYGILHSVNVGHQRMFIVNFDNPYCLEKYLEQYFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSS0</accession>
    <name>A0A0D8XSS0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_07084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716332">
        <property type="protein sequence ID" value="KJH46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSS0"/>
    <dbReference type="STRING" id="29172.A0A0D8XSS0"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049400">
        <property type="entry name" value="DYNC2H1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF352">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21264">
        <property type="entry name" value="DYNC2H1_AAA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="172"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase" evidence="16">
        <location>
            <begin position="651"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="17">
        <location>
            <begin position="887"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123391" checksum="BF21467DC3ADE466" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT11</accession>
    <name>A0A0D8XT11_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716330">
        <property type="protein sequence ID" value="KJH46889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT11"/>
    <dbReference type="STRING" id="29172.A0A0D8XT11"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF5">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="276" mass="31741" checksum="AFF83DD0C8648771" modified="2015-05-27" version="1">MSLFRNTNLFQAVNTKDRSLKVLSEFVERISAKKVDGIVKEYKRLDNFYDVTATYEAFKSNMVKNRYSDVVCIDSTRVKLELGEKDFGDYIHANYVSFPLLTTKFICTQGPLQSTIHDFWRMIFQERIESVLMLCNWPDRGVPDHNSCLIPLQLLDRIRHAPCVVHCSAGIGRTGSIIALEIALQDVVAGNTIDFERIARELRCARAQCIQTQVQYLYIHRVMIENALMHINLDESTKATGKKFLQDYDSKLQKGVLCCQIPTFSYVVYFAILKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTB9</accession>
    <name>A0A0D8XTB9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH47009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTB9"/>
    <dbReference type="STRING" id="29172.A0A0D8XTB9"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000197">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="890" mass="102525" checksum="0A3387805E97CDDB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTC3</accession>
    <name>A0A0D8XTC3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_06832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716321">
        <property type="protein sequence ID" value="KJH47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTC3"/>
    <dbReference type="STRING" id="29172.A0A0D8XTC3"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="358"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="10">
        <location>
            <begin position="705"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="953" mass="108902" checksum="CD625B8C8BBA943F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTI4</accession>
    <name>A0A0D8XTI4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Putative exosome complex component RRP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
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    </dbReference>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="239" mass="26325" checksum="AFD25451A46BE3E1" modified="2015-05-27" version="1">MSIVSEHGFRLDGRRPHQIRNINVALGTITDAEGSAFLEQGCTKILCAVYGPYEGKKSRQLEDRCAINCIFSMTRFAGVERRQRTRADRKSMEIERLIEKTFEGAVQTHLFPTSQIDIYCQIIQGDGSHLAACVNAASLAMSDAGIPMKGLVAAATCSIVDGQPVVDVNQREENDLLPRLTLATLRGEDEVVLVELQNRVHVDYLPTLMAAAKDTCKGVHECICAALVDQLENGTFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTL8</accession>
    <name>A0A0D8XTL8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716392">
        <property type="protein sequence ID" value="KJH45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTL8"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Neur_channel"/>
    </dbReference>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="170" mass="19817" checksum="4514A9F7B6AF93EF" modified="2015-05-27" version="1">MVQLRWMDKAVTLMKPIQLPDFDLVHFETKKENLLYPNGYWDQLQVVFTFKRRYGFYIIQAYVPTYLTIIVSWVSFCMEPKALPARTTVGISSLLALTFQVIESPMLAPNKVTLPRADYNWGLKQNFVTVWKYPEELAESFLCKSDGCMDVGMYLVRFWHYGGVGVCLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTY2</accession>
    <name>A0A0D8XTY2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Immunoglobulin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716315">
        <property type="protein sequence ID" value="KJH47267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XTY2"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000637">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001694">
        <property type="entry name" value="Basement membrane proteoglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="389"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="52872" checksum="017C6B6818B62A6F" modified="2015-05-27" version="1">MQNTLLQKIPELCFLAERGPQISPPEQTVQEGDPVSIRCWVEGDPKAALSFKRADGDPLPFGATENDGILAISSTLKSDQGDYICTYHPPDGGVPKDSSPSTLNVKSPGGPPRPVATPPVLTVKKGQPAQFHCDAHSPTPAQIKWGYGDSDSDLPEGVTHTNDDIIIDAADDLHEGEYVCLATNEYGSGVAEPVKLIVTEDEQPPTARVEPRVWNGKPGDRHQFKCIVTGIPTPTVTWSGPNNTPLPHDVTELDGNVLDFSNGRTELNGDYTCTATNPVGEASDYGSVNIGPSLTVKTTPAGPRLILTAGEPLHVKCEAFGDPEPEVEWLHDPGPERGDLPDDYKPVTISEQFIRHPAIGLGNAGAYTCKGSNSHATATKNIYIEVVEPSRVATVSILGGSSQWFEQGEPSELICTATGSSLVDRLEWIKVDDQLPTDVEEHNEPGLLHFPNFKNSYAGEYECRGYRNNELIASSSVQVYSTTDDTDDAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU33</accession>
    <name>A0A0D8XU33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716313">
        <property type="protein sequence ID" value="KJH47322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU33"/>
    <dbReference type="OrthoDB" id="5814004at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336068" evidence="5">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="14833" checksum="BFFFA784E24892D5" modified="2015-05-27" version="1">MILTCVVFSILVATVIPKQQTYTVTGVLQCNGNPATNQLIEMKFTDPLLKGKVTASTSADNKGAFKINGSQKGRAGQTAYLWVEHNCDSKNRNNCHVMTFISIPKKYVGKQYNIGMYELSKHVYYNTCDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUG3</accession>
    <name>A0A0D8XUG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716309">
        <property type="protein sequence ID" value="KJH47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUG3"/>
    <dbReference type="STRING" id="29172.A0A0D8XUG3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="509" mass="58843" checksum="FE4DC48E7EAC7BBA" modified="2015-05-27" version="1">MGLFAVALVIAALTWISNFLYKRIKYVLKQIAVFQGPVALPLIGNLTQFHFKPEEFFEQAQGLAYMLRNGEDRICRIWFGPIPFVLLYGPKECEAVLGSNKLLNKPIQYSFLSPWIGEGLLISKPDKWRSRRKLLTPTFHYEILKDFVEVYNRHGQTLLEKFLKNADRGQYEDIFHTVTLCTLDVICEAALGICIDAQKKPHSPYLEAVFRMKVIVQQRQVKPQYYSQLIFDLFGDGKEQQQCVKILHEFTGNTLSLQIMVVQRQVFVLHTVNGLGRRRMAFLDLMLDMHSKGELSMEGIQEEVDTFTFEGHDTTSASINWFLHLMGAHPHIQEKVQREVDEVLGETDRTPTYEDLGSLKYLEACVKETLRLYPSVPLIARQVVEDVKIRDHLLPAGTGVAVIPSMVHRDPNYWDDPEVFRPERFINGEIKHPYAYIPFSAGSRNCIGQRFALMEEKCILALLMRHLRVRSLLRTDQMRVAQELIIRPLYGNRLKFERRSYGDYSHCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUI2</accession>
    <name>A0A0D8XUI2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716372">
        <property type="protein sequence ID" value="KJH46041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUI2"/>
    <dbReference type="STRING" id="29172.A0A0D8XUI2"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="406" mass="46854" checksum="F02AC0F1E3AE590A" modified="2015-05-27" version="1">MSSRERRNWIRIAAKEIVCGIPNSQDELLDLPSVSALPPYECFAERISVSSAIEKFEEDARIGDILIVKVKKCDLVGAYVKPLCFATRIKRDLEWLNMQFLTSLSTFSRRISVGQYLEARIVSVQPVKVELREAAPLASAEFPEYFRNGREMSSHSHYGEYVDSSGMLRNTYLTETLHLPTKSSYSFLKLDGLEKDRAEPASLLRKRQNEMLADEFVVRGVEQMKSGNRESAIVVLNQALEINPECVEALVARGAAYSTNGQYVLAEADFDQALSLVPTHTNARNYLVETLVKHASLLEVQGDLENAKCKFEKVLQIKDDRRAKTALAKFNRRKKSPSVEIVEIENNRSTSKRNSCTHERNRDDIEEEKRKRRRTQEVERERKRERYDNREKLRQMEEFIKKLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUT7</accession>
    <name>A0A0D8XUT7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Immunoglobulin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716300">
        <property type="protein sequence ID" value="KJH47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUT7"/>
    <dbReference type="STRING" id="29172.A0A0D8XUT7"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF269">
        <property type="entry name" value="FASCILIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="502" mass="56877" checksum="875DB58423C20A6A" modified="2015-05-27" version="1">MYSRTIISQLYIHFIVIFLFQICQVRSIFGHPPSFRDEDYPTSITLNEGQSLLLNCRAEFAEQFYWLKNGHHTFVETNLYQIVESSRNDSGVYRCVASNEVASTLSPSIRVNIEYLDGFEESDMSDHFISATEGGYFVIKRPMLIANTERIANAKYSWYNNDKQVYSSDSCYVTSRGDLVVLDATSSDFGNYKVVASIDGLGEVISKVFVVRKNNDMVDPSDVLRIIYFSDSRKIVLSEPSGMKIETFDCVSSLKDGVRTRWFMNERSVSGNERGISLSQNNRSLLIKLPDALDSVCLNDFTLYFSAFCILIKNYFSDLQNLSEYKLDCKADASSGVMFDRRSLTIDIIEIPILKPAPTEIFRPLGSALTIPCSRKRRRDISSSIQWYFNGREFATRKSRLVIQKLSRKDYGIYQCEASNDAGSTMNTVWVKEGMSPTTDFLRSEDEPVEEVSGIGFGAPVIITPPKNHSFIVGSKALKLQCIATGVPSTTIIWRFHGKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV98</accession>
    <name>A0A0D8XV98_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylosome subunit pICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pICln (TC 1.A.47) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716263">
        <property type="protein sequence ID" value="KJH48563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV98"/>
    <dbReference type="STRING" id="29172.A0A0D8XV98"/>
    <dbReference type="OrthoDB" id="5869052at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003521">
        <property type="entry name" value="ICln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01348">
        <property type="entry name" value="ICLNCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="695" mass="78405" checksum="1F5B6EB9F9755292" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVF8</accession>
    <name>A0A0D8XVF8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_05406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716266">
        <property type="protein sequence ID" value="KJH48495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVF8"/>
    <dbReference type="STRING" id="29172.A0A0D8XVF8"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF127">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH48495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="27870" checksum="BCF4778B10BEB2A0" modified="2015-05-27" version="1">MDNDISEALRQVLYGSGHDFGGDRIVEDSTTVQVKNPAGRNTGEEMEVYYSRTSQVLSQPNSDDEDFATLSDSELTEHCRKSSFRRGTCGSDDEGKKHTVLRYRRRRGGQWRQVQGTDSSTRKGDEDELEVDVTEECSETTGIVTKTYEARWKVLKYEHLPDWLQDNEFLRHGHRPPLPSFSECFKSIWSLHTETGNIWTHLIGCLAFFCLGVWFLTRPDNHIQWQEKIVFSFFLVVPFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVS2</accession>
    <name>A0A0D8XVS2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopterin-dependent aromatic amino acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716352">
        <property type="protein sequence ID" value="KJH46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVS2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVS2"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="401" mass="45240" checksum="A5B38EFA9835E86C" modified="2015-05-27" version="1">MRQSELWFPRHISELDKCSNCFTKYDPVSDPRHPGYQDEAYIARRNFLNSIASGYKYGEPIPIVEYTDEEHAIWKSVYNHLSTLRESYTCLAYRRNLRMLEDEGILSPEKIPQIRDVNEFLQKKTGFVLRPCAGLLSARDFLTSLAFRVFQTTMYVRHSAKPHHSPEPDLIHELLGHVPMFADPMVAQLSQEIGLMSLGASDEEIEKLATVYWFIIEFGLCKEDGQLKAIGAGLVSAYGELLHACSDSPEHRDFDPALTAVQKYEDSDYQPVYFVAHSIKDALVKLRNYALTLDRDFVTMYDPFTRSIELAINASWGQPGCAAPADVEVVWLSGKRLCGKSGVATGNLRFDKEFGSLMTEQGGRLSGVIRHISQLAPAYERLHADIGATTLVNEKLSMKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVT9</accession>
    <name>A0A0D8XVT9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH48728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10376" checksum="A7FA7024275F3A81" modified="2015-05-27" version="1">MKLNIRKRSSIYHEVDHSFTVMLLGDSCTGKTCLLVRYKDGAFLSNNFISTVGIDYRNKVIDIDNKKVKLQVIFFRMILKKLSSHETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVV1</accession>
    <name>A0A0D8XVV1_DICVI</name>
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            <fullName evidence="1">Proteasome activator Blm10 middle HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="496"/>
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        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="528" mass="62058" checksum="3AE7C5698C7E03DC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWY5</accession>
    <name>A0A0D8XWY5_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DICVIV_04863</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716248">
        <property type="protein sequence ID" value="KJH49025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="182"/>
        </location>
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            <end position="284"/>
        </location>
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        <location>
            <begin position="437"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
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        </location>
    </feature>
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        <location>
            <begin position="467"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="814" mass="90296" checksum="22B58C7F5485F347" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX23</accession>
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            <fullName evidence="7">UNC-50 family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">DICVIV_04772</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="291" mass="33878" checksum="A9D84B66A632FC40" modified="2015-05-27" version="1">MLHPLAYQPGTSGILLPPTTKQFRLGTTSRSGCSTPGGYSTTSGTDRIGCFTAVRMSAWAKLTRFSRRFIHFKQMDFEFATWQMFYLLIQPQKVYRNFIYRKRTKDQFARDDPAFLVLLSLSLFFSSVFYAVVLGLTIWGFIKFLFWVIFIDCIGVGLVVATILWWFSNRYLRKVQDQDVEWGYCFDVHLNAFFPMLILLHVALPIIYPTLVNSPSFLPTAFGNTIWFIAAVYYVYITFLGYTALPILHRTHYFLYPMTFLFILWVATITAGWNISRSAMGFYNYRVRSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXB4</accession>
    <name>A0A0D8XXB4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXB4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11848" checksum="985C34F906CD239D" modified="2015-05-27" version="1">MKNFAFERIQIKQQQRILCWGTLRTEHEVVFLKQFDDVELGYDAPGRRFDHSLLQSVASFSSSSTLLMNEWKKKEKRRKSHERVSHSGVQLTVGHEFSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY01</accession>
    <name>A0A0D8XY01_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="12">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_05241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY01"/>
    <dbReference type="STRING" id="29172.A0A0D8XY01"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="69"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="630" mass="72617" checksum="2F370E496B74DCD1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY63</accession>
    <name>A0A0D8XY63_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY63"/>
    <dbReference type="STRING" id="29172.A0A0D8XY63"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="172"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="529" mass="57236" checksum="70B26FA451EE8BC7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYR3</accession>
    <name>A0A0D8XYR3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYR3"/>
    <dbReference type="STRING" id="29172.A0A0D8XYR3"/>
    <dbReference type="OrthoDB" id="3173at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="12">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH48987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="29990" checksum="CE628496AF8ED5BA" modified="2015-05-27" version="1">MSVITRNNCNLSSYSPLQGLHKQMCTICGRKRKYFCYDCRVLLPGVFSPFVKVCETMTPAKFLLTDSKNIKGILPCAVDVIKHPMEKNSKSSAIHCKIVAPDQTRIFDLPNVVEYNKEEKQKGGGSDVLVFASPSAVSIEEFVMTFGPIKRFIILDCTWFQVNTMLKIPQIQGIPCVSLTKYHTAFWRPQHNVDKCSLATIEAIYYALKEYQEYGLKLPYKGEFDDLLYWFFHTQHHIEKKQVEYSKRKLRDTEMMSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZJ0</accession>
    <name>A0A0D8XZJ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZJ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XZJ0"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="32043" checksum="D45C8D506351C83E" modified="2015-05-27" version="1">MPAIYNDQKARLNIIEALLHRRAKILYAPNVDVVQKVIHKANESFAFIHQLNIFARLVTDFVKKSDAKSLNTTEVISQSSIEFMKWYYGTTHPLRFLIRGLYNFNRTEVIEKWNLLVEETSLNATLPSFIGVVFNNINEKDTSLGPVVTYKIRQKPDFIPTTRATHDKFTAFFGPRIWDDLYYSYGFLWLQDVIERSIISAITGITFVEPGAGIEEMAFPCFRYDRYCNRLEWTGLLFGCRGFFPYYHRLRSPIPSMLFYYSVMKPYFDPPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y140</accession>
    <name>A0A0D8Y140_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y140"/>
    <dbReference type="STRING" id="29172.A0A0D8Y140"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </evidence>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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    <sequence length="352" mass="41320" checksum="A3177AFC4F291200" modified="2015-05-27" version="1">MNKFSIHKTKVDGFRIRSRTNSPHRSERKRLLQFMLIRYKCMDCCQASFQIINFRHIYKKRCIFILIAISVYSFFVINRYHHQDKFVTFTLNHSTFSDQLFEICVGTILAKAVGRRFHILDGLRPKQTRSQLKLIARMFPSLRKQMSYIKNSTSVTFVQYDYYTKRNLKRFCDSQRGGLVFDFQYAFDISMLEQNEGVLRRMLEFSDSIQPNQQQMLQKYNITTKHSAICVHIDGKVQLLKDDEIVNTHNIVVASREIAMKMNLTQFYVFIDDKSFSRAITDLLSSYNNWQPNVHISQWTQAMELYMVKQICGAVLLTSMQSIHGFLIGIFAAPNVVYYLASKKSNGTQLYL</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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    <sequence length="255" mass="29762" checksum="150D3B2DAAE9970E" modified="2015-05-27" version="1">MASICRYDDWDNLTYKKPKRLSVPCARMESDGEWFQINRILDTVFVAGSNKGWQSLVQWKPSWSQDIHASLAVKDFYSKATVLGCVVKDSFLRSRIRRKIEWNRKEFMCMNFRVQIHRPDGSTMYEDIPYPDVKRRFPAALFEYFENKMHPHRVAKADESRKDGLLSIYNNVTDSVVMSRCIFANRELPKRKEIDIHTKTPILKEDHSTILGNVPKLPRMKCGKKRSCELLYGVESCSVVQKKPTFGNEWDLNSA</sequence>
</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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    <sequence length="72" mass="8705" checksum="7E31EC582EAE5DE1" modified="2015-05-27" version="1">MSQYWSDFEYTQPIYENNNKGTFTVFHDNDFDWFLKADDDTYFHMDNLRTFLKVQLASFFAKIIEVDFVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y380</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
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        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
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    <sequence length="885" mass="102428" checksum="9B081533C23255CE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y428</accession>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y428"/>
    <dbReference type="STRING" id="29172.A0A0D8Y428"/>
    <dbReference type="OrthoDB" id="5845363at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336450" description="I/LWEQ domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="3">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="10093" checksum="2E8EA69C255A7B1F" modified="2015-05-27" version="1">MFTAVLMILHMLGAASIMDGTEFVKKKAELSRLVMDAQEQVLRKEKELVHARERLANLNKARYERGVSPDHRNKVPFLSFSHPLSLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4G2</accession>
    <name>A0A0D8Y4G2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Patched family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_04393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716234">
        <property type="protein sequence ID" value="KJH49456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y4G2"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
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        <location>
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            <end position="150"/>
        </location>
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="319" mass="35874" checksum="1EFDFF75FF2C55E7" modified="2015-05-27" version="1">MKITTHYYDNQGKTRMRTLKLDATAPCITRSQDFVWSNTDDYEKLSLVSFRFRIGLHDISTPTDLVMVTAQVRELAAQSPDLDIFTYQYSRPIADQLNVILQSTIQNDSLAVLCMVLISLLFIPNPLCALWITIAIVTIDIGVIGLLSLWSVKLDPIFMITIILSIGFSIEFSGVTLKWNGKGDYVHFFVLKDLLLSLTHVTHGFVSSEGNLSPKERCIEAMEKLAWPVVHGSMSTILGVAVLAFINSYMVLVFFKTIFLVLVIGVIHALLLLPIVLSITTPYVEQFDSYLQHFTKTKKHKNRISRSNVYAITVPVNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5U1</accession>
    <name>A0A0D8Y5U1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">DICVIV_02304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5U1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12493" checksum="A091CC410F075196" modified="2015-05-27" version="1">MGPSTLALQHSEKIEKTGGDISYSSHSRKRVIDKTPQKRISSSYSIIEKILSASRPRTRNDRDFAGETFDLSIIAHWTFRMLKEKNRTVKRNHRLYGGISVLLMEMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y653</accession>
    <name>A0A0D8Y653_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hsp90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y653"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="endoplasmin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <end position="177"/>
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    </evidence>
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    </evidence>
    <sequence length="207" mass="24198" checksum="3DE8F78F6B458E37" modified="2015-05-27" version="1">MRLWTTPTGLFPYSFDEVASVFWDRYPNSYAKHIVSEDVLERRITENTIVTKKLIVKNGSSILKRVPRWLSRMTEIRTVPVIEESVYDRRSKTLTTYTRNVSHNELFALHERCVYRPSMDSLNIPMTEILRSVYITIDCGRMSSVYEKLMLLGFKKSVLNTGRGLIELLEQRFGIRNLSAVPKEKMKVIRDKLFKTPLVSELKCEDK</sequence>
</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <begin position="12"/>
            <end position="33"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <sequence length="190" mass="21048" checksum="AC65F3F0D1C093E3" modified="2015-05-27" version="1">MAASFMDHWEIVDLLLDHGANIYEIDSAGATALHLALSNGSKTEAHDKTIQTLIKRGSDLTLADAHGRVCLHLAAYYGDQNLESLIGHTCIDIQDALGRTPLMLAASQGQLKAVDQLIKHGEAKITSRLLYFPLLDNKSKPTNLNQRFPIFITRNFYRTLECAFYLNSLSIFVSQLSSVALFNYAKPVLI</sequence>
</entry>
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    <accession>A0A0D8Y9F1</accession>
    <name>A0A0D8Y9F1_DICVI</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
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    </reference>
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        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
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        <subcellularLocation>
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            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
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        <property type="entry name" value="PROTEIN WNT-16"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH52822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="31992" checksum="1315BE92CEA25461" modified="2015-05-27" version="1">MLYRYFRSLALLSSSDYNPRPLSHGDRAHYEVLCNRLLGLNPVQRALCVQNPFSIPFVARGIREAIYECQIQFKFERWNCSDRHEITPTPHGNFQDIFGKTLRSTTKETAFLAAIASAGIVHAITKGCNTGNLTDCGCDNKPSLQKYVEGDQTNLPGRYEQFSWGGCSDNVPYGQRYARQFLDEYEKQQFEKDRNVSHLVMKHNFLVGREAISQNIRRQCRCHGVSGSCEFKTCWLQMPKFNEVAEMLKKRYDHFAVQVEMDVITHPLHIHLFLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9S2</accession>
    <name>A0A0D8Y9S2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9S2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="51" mass="5854" checksum="92A1BBD747550A55" modified="2015-05-27" version="1">MLVTSVNEHRKERIAQTLVCQKFGRDITINFHQCQQMAHKTATIHGKGLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA69</accession>
    <name>A0A0D8YA69_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA69"/>
    <dbReference type="STRING" id="29172.A0A0D8YA69"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12133" checksum="35E519CCBC50F8E6" modified="2015-05-27" version="1">MDLSVSRSGIIALYNRFLSLATHRDKATNEYFLTEVDFQNIADLQQNPLGQRIIDAFFADAKNEGRGRIAAILKSGEVRKLEDDCVHRTIMGPFGPKSVTAVTKVRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAF9</accession>
    <name>A0A0D8YAF9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAF9"/>
    <dbReference type="STRING" id="29172.A0A0D8YAF9"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000011">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="695" mass="77687" checksum="B54919168FCA82C6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAH6</accession>
    <name>A0A0D8YAH6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAH6"/>
    <dbReference type="STRING" id="29172.A0A0D8YAH6"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000200">
        <property type="entry name" value="Protein CBG10739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="80"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="285" mass="31967" checksum="D7653555D3A94F98" modified="2015-05-27" version="1">MRWLSSQSTSLACSFHVSRCSNLLFSTGSKYKLGKRPSFVKQRECSAVKIVSPNTSSSWEAILPRRRTGEKIDVAQNFDFLLVLDFEATCCDDGPILPYQEIIEFPVAKLDTSSWTVSSIFHQYVRPTANPNITSFCTHLTGIVQEMVDSQQAIDKVLSDFDDWMKKEELLKSRFAFVTCGDWDLGVMLPAEAGVKNITIPSYFNSWINVKKSYCEHSGVFAKGLRHLLKAYNLTHSGHIHSGIDDVKTICAVTTAIAKEGYVYRINGSTVDDTVPKKLFRNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAW1</accession>
    <name>A0A0D8YAW1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_02102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAW1"/>
    <dbReference type="STRING" id="29172.A0A0D8YAW1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="584"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="682" mass="77755" checksum="5AF344F54C45C167" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCN7</accession>
    <name>A0A0D8YCN7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCN7"/>
    <dbReference type="STRING" id="29172.A0A0D8YCN7"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="607" mass="68687" checksum="D8695E640E5F342A" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8YEY9</accession>
    <name>A0A0D8YEY9_DICVI</name>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="278" mass="31768" checksum="AC656D8E2F4D89EF" modified="2015-05-27" version="1">MEQSFKFFFQAVGVCASAYTLAVIAVERYYAICRPLQSRNWRTKRRAVLTISLVWIFSFVCNIGTLFIFDSVPYRNQWTCDTYGGPLIDFIYQLYVTLVLLFIPLCVMVGLYGHVIYSLSTVVVTDNPTVQQSLQQNGAQQLSSSAISEWLFDALLNNPSINVGNFKEKILIAKKKVTRMLLTIVAAFAVCWLPNFLWWLLVRASDLAGVPMWHSGLNMFLTVLTYISSTTNPITYCFMNKSFRSSILSHCTKKKRPVSGIIDYFVPKEKLFHPVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YGB4</accession>
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        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14333" checksum="3F15147AD0185AFE" modified="2015-05-27" version="1">MSYLNRPEGEMDMMIGFFLMNGFCVAHVSRAIRLGALKSMKKASEGIDCIVEEKQLDDETSQQCVVEKRNSDEVENQVHLPKLSLQSDENFRVLRSVQIEETHANTSSIVRQNLLGPLSFDDLHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X625</accession>
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    <protein>
        <submittedName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENaC"/>
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        <property type="entry name" value="ENaC_CS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="403" mass="46948" checksum="DF7658011DDCA947" modified="2015-05-27" version="1">MTLLLYFNQASMYWLKTHRLPKDLLHIAQRFCIRFFINLINRRDLNLLSVSINVTIPNGIYACMIRLVTDTENSHDFQSERRHCKTSLVAISGHGVSPSQQISVLTQKESINHLEKDIYSDENVTSDEVTKNRRESDESDADSDLRFELWDNLRTASQDPLDDLVIASKKTSEIDVDEYFLTSLSPNYVGKRHPDAEMYVKRGIKNKKLRYDLTKRLFDIFRDQCFNGELPESLIITWNTRLRKTAGLCRNKSDRTSCIELSPKVCSTPDRVRDTLVHEMCHAAVWIVDGQRKEGHGRKWREWASKCMRRFRSLPIIDRCHNYEIQTKFIYECEGCGQQIRRHTKSLNVERWRCGICKCSFTLNVCARPKNSGVVPVLNPFAKFVKENYAKHKNPSVKHGEVR</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716778">
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41685.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17017" checksum="43136FFFD178440E" modified="2015-05-27" version="1">MGVTMSQTYRIVKRLAFTRECSLCPPGTSSEGGAAECIPCAPGYFSPKGAAKCGKCPQTHFSGPKAEHCLERPACRFTDFYPVTEPCINGTTRTIYKKIQPALCRDDIPESVKLPPPSAFRPCPPCNPGMAKDAKGICAFCPAQHFSQGEGQLVINDD</sequence>
</entry>
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    <accession>A0A0D8XAS7</accession>
    <name>A0A0D8XAS7_DICVI</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN723063">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335457" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="45" mass="5379" checksum="47259375738CC9B7" modified="2015-05-27" version="1">MSVAIYWKQVLLLQLLSTLEKEPMDRCEYYLENEGFLLDVTEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAT7</accession>
    <name>A0A0D8XAT7_DICVI</name>
    <protein>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717028">
        <property type="protein sequence ID" value="KJH40749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAT7"/>
    <dbReference type="STRING" id="29172.A0A0D8XAT7"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF3">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="136"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="415" mass="46566" checksum="1484C596182E2D1F" modified="2015-05-27" version="1">MVINAVKLQLKGRAIWLNDPLKNDNIEKVYFDQDFTLLERPPGKPEPGHFTWIGGFPYSLPFECPLPKGCPASYEGPYAFIRYFIKASIIHEQEDGGTKEYYVKKAFSIVPVCEGQVIKGEPVVVNELALYGSCCCKKKISAELILPKTVYLPGEVVVGTLKIGDKFPKDILQHVEIRLVDRVFRVGAPEKLATSPCRTLFCRKNQPTKITKRGREIWDNLYLLTIPALFLFSEILDPLKNEIRSIKTCATVVESPSTATLRLRKQPFIKIEYAIQVSLGNSVMLEAPITIGELSLHDSTTILKPFVGGPQPIEEVDETQRISIGGPFMYTPMYAILKNSDDVNCNTDEHAIPMSSVISTDVGSLFGKETITRQQDITTTNYEISVPNHDEIDLKTPEYVNDEEIHVCSCSMHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB60</accession>
    <name>A0A0D8XB60_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716982">
        <property type="protein sequence ID" value="KJH40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB60"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="10333" checksum="13F038F290AC6ED6" modified="2015-05-27" version="1">MAVFVQLRRMTVRMYEQKFFESTITEDESGEYSTNLTNLCVDSPFQRYWKKNTTCSRSNAVVYVIDRHRFEEDESATKSSSSVISKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBK3</accession>
    <name>A0A0D8XBK3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716926">
        <property type="protein sequence ID" value="KJH41034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBK3"/>
    <dbReference type="STRING" id="29172.A0A0D8XBK3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13656" checksum="D4226606189024CE" modified="2015-05-27" version="1">MTVNGPMITLANGVKMPQVGLGTWQSSFSEVKTAVKVAVESGYRLIDTAACYQNEGAIGEAIQEMIKDGKIKREELFITTKLWVTHLHPDDCEEAIHKSLELLQLDYVDLYLAHMPVCFNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBZ2</accession>
    <name>A0A0D8XBZ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718835">
        <property type="protein sequence ID" value="KJH39991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XBZ2"/>
    <dbReference type="OrthoDB" id="35661at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="24556" checksum="547B6B19A5613AF8" modified="2015-05-27" version="1" fragment="single">SVDAKDSLLDLVKVQKESYKSFTPGSYDNEGLESVFHSVFPVNDPLHGATIKFISCRIDDLKYDESECIKRVITFSARVIASIRLVVVQDGIPLDEYRSIKESGDLSKLASIVKFIEEQEVHLCELPMMTDKGTFIINVVEKKVPFIPDKFRGVRLPFDLMDVKGNVLLKANVRVTSRLAKKLYDDGLKEYLVPFDSICGLFLAEDSIDDVSSTKILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCK5</accession>
    <name>A0A0D8XCK5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_11661</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KN716676">
        <property type="protein sequence ID" value="KJH42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCK5"/>
    <dbReference type="STRING" id="29172.A0A0D8XCK5"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="43684" checksum="9316271D879EE209" modified="2015-05-27" version="1">MRQIRKLAETPVSTSASSSTISDEQSAFEHSRRATFVGTAQYVSPEMLRGDDVGPPCDYWALGAIVFQMISGLAPFRAINDFHLMNKIQKLDFTFPSGFPEIAKDLVSKLLVLDPAIRLGSDDLSKLKSHEFFSGINWDYISDMKPPDIFLSVSEAIEEAETAELDMFEPGLSEKTLNRLMNLSLSEMEPRKQPPLSGEILSVAVDIPSDMIELPKMDKKAIAARQRKLEKQRKENPYHSFVQDNLIIRSGFIDKKKGLFSRRRMFLLTEGPHLFYVDPNNMELKGEVPWSPCMRTEVKNFRTFFVHTPKRIYYLFDPESRAIEWCKAIDQVKMRYADKIAESYARAVKDGTFGMKKYKKSTNYFGDKRKKKEENGKRNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCQ5</accession>
    <name>A0A0D8XCQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717556">
        <property type="protein sequence ID" value="KJH40206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCQ5"/>
    <dbReference type="OrthoDB" id="5836304at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="9716" checksum="435D4D826A97A479" modified="2015-05-27" version="1">MAAKEKNCYIIGDTVTNLCLMMAVGNNNCVAGDVPQEFMNLAGTLTTTNIILANWQNPMWQDVMNRALRSLSSRPFSSNFIRASIMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD06</accession>
    <name>A0A0D8XD06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716657">
        <property type="protein sequence ID" value="KJH42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD06"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10350" checksum="293522234A2AEBD5" modified="2015-05-27" version="1">MCDILNHRKQRFVVFTQGFRSLVLSHILLQINNRNLAQLESPLVAGIRDFDYHGDVLFSLHSIASSYNCDFVAFLVFLKLLMDLENFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD86</accession>
    <name>A0A0D8XD86_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-sigma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="KN716648">
        <property type="protein sequence ID" value="KJH42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD86"/>
    <dbReference type="STRING" id="29172.A0A0D8XD86"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione S-Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23659" checksum="B213FA4916943FCE" modified="2015-05-27" version="1">MVQYKVIFLSGRGPAECARQLLALAGQEFEDVRLSKEQYHAIKTNVPFGQLPVLEVDGRQLIEPMAINRFIARTFGFTGSDLFDEATADSIADRYIFYRDRINEYHAALLTQKPASVLKKLEGTVLFPARDKFFGYITKHLEKNSANGWLVGVSLTWVDVLIAEHASEFSEKVPGFLNGFPQVEAHMRKVRSIPNLKKWLENRPQTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDS9</accession>
    <name>A0A0D8XDS9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717095">
        <property type="protein sequence ID" value="KJH40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XDS9"/>
    <dbReference type="OrthoDB" id="5806678at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
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        <property type="entry name" value="MUN_dom"/>
    </dbReference>
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        <property type="entry name" value="Munc13_1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="417" mass="47366" checksum="EAB3387B33178182" modified="2015-05-27" version="1">MDVQPPDSWDAFPLFQTLNDFLLSEKSLNGGIFHKKLTAQFQPLVVRYIDLMEHSISQSIDKGFSKEKWEPRKEGCATSEDIYWKLDALHIFVVDLNWPEEEFRKYLNVRMKSLSSDMILKVASSTYQQFDYWMQRARKSTDYILPSEVCVMINVLFSSKARAMRVSVDAGEFKYQSKLDETLDTMLSDMETCIQDRLIGVLEFVLGKLARYDEGNPIGALLSMAPKPTSLFNKMKTMVGEQGISISGTSSSTTSASPNTKTAVSQQQSTVHLGNTYVVFMRGCTEQLRQIVTDEVWVNTLFENWYANQVRMINEWLTERLQQSLSPYQFTCVSFIVKKLYSDFELQGIDEEKLNGKIYQSISRRLQLEETNVALHDHCNGHTPSVFPTSLGNASAAVSNVSSMVEGAGAKVFSFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDW3</accession>
    <name>A0A0D8XDW3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716750">
        <property type="protein sequence ID" value="KJH41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDW3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDW3"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11877">
        <property type="entry name" value="SH3_PIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="114"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="24890" checksum="79397FAE1B9BD126" modified="2015-05-27" version="1">MSETEIENQHHESSIVVAKAKFNFEGKNNDELTFCKNDTITVTQQLEGGWWEGTINGKTGWFPANYVSVMTEKDKLMRSRSVPNAVALMNGVISASGIPVYGDVASSTATRTQFRVEIIRDFIRAEENYVTNVHKTYEELLLPIRAAAILSPEDYAILSCYIEEIFTLQKNTLIQLKETASLNVSRQRIGGILISTAGELKRLLVAYCENHPKAVEVLNEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDY0</accession>
    <name>A0A0D8XDY0_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Zinc finger, C3HC4 type</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">DICVIV_12042</name>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716729">
        <property type="protein sequence ID" value="KJH41972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XDY0"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, C3HC4 type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="DUF6535"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF6535"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00744">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
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            <begin position="20"/>
            <end position="88"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="23183" checksum="E9490FF2C306A171" modified="2015-05-27" version="1">MRLEHCSPSLPSLHSLSLSDLSCNEPLCRICHCSWPSDASDPLISPCRCSGSLRYVHVSCLMHWLDLSSRKLHRPAVCELCLYKYRRRRVLKYHEIKLPNCSDRDLRYYTLLICALGMMVLSALATIVCFQLEKSYSNRTTSSQFPISEAMLTESSTSNNLLHRENIINLLSTVTLIAAILFFFSFFMAMYAHVKVSCPLSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE64</accession>
    <name>A0A0D8XE64_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716733">
        <property type="protein sequence ID" value="KJH41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XE64"/>
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        <location>
            <begin position="31"/>
            <end position="50"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="26602" checksum="3DE5029FBF5B1FB2" modified="2015-05-27" version="1">MHLSFASHLVLKRQKMSEEHIQYKFCSVRSALLCVAVVIVGVSVGSFYSYNDLKEIFFQIQERVYGPVISSITNDHKNTDNKKNEEHKQVTSDRRKSQQTDERERMREQQLREQQERKRRQKEQERIRQQQEESEEVKRLQERKAEEIAPIEQKGNDMERNEQQQELKQKFSQHYQENTEDHQRQQTQSTRKQHEAVANKQNVPLQEQNPSQQHHHETQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEC3</accession>
    <name>A0A0D8XEC3_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Chorein N-terminal domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716723">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VPS13"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="765" mass="88375" checksum="0BF8D65C82AFBED0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XER9</accession>
    <name>A0A0D8XER9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="436" mass="50144" checksum="23AB3FCB33F6CC3F" modified="2015-05-27" version="1">MDSLLDPLRLHSDRSQSPAFMPREDDYAELLRNTDFDVRLQTLNRLVGIVRRDPEWFTKCARKGELFKNIDRILMDDRWEVQHQCIKFLQEAMITFGSPLRRKKKVGNLEYCMCYLMPNLIPKLGSSKITVRKISVQTIQTFLRHKPEALGSVLKTLSSFLLTSIERITKTEVMREFSAMFIPELVDYDWLPLLDALTKLLATSDTDTVENAALLAKKLEGLDESPREEIFLIYINVYQKIIELLFSAAEAIRIKTQSVHSRIEIFGELFPMKKKYNEIYLGKTIFTRMLGDLSNIQQKNYARFCTNIVVTTSESTPIAPSIVTNRSSMKLASGERRLRFGIVPSIVAAMVIDNTDVSTRISGLEKWKQLIENITSEEISRLVPHLHSYLISLKNVLNELNFKIVVLALDIVRLTVNRLKSHIEAHLQVDSTISQY</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="12"/>
            <end position="36"/>
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    </feature>
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            <begin position="66"/>
            <end position="87"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="108"/>
            <end position="135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="189" mass="21481" checksum="FDD9EC1F6CB6E5E7" modified="2015-05-27" version="1">MRIVYFFFQLRIFLRLLTVMVIATGVSSIMSLQFFLQVSWSTMIKKYVAIKEFYKVAGEIGETLDIAVLVCSNSAFFVSLLQLFFVLKLQKSHNTNTTISIDYLERTSFMRIIIYSFWFLAVILLMTAVLLLFALNPQRGTISRGVGVSLGVSAIVFCAVITLKSIRFWTRSSPTSTTVDNYKNFSTLV</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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            <begin position="225"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="381" mass="41758" checksum="B4C2240820668656" modified="2015-05-27" version="1">MVYITRSSSKSGNHELSKNSELPADVSTSVEQKQDELYGMNITGDASNEIHETKSESSTEVDPLATIPKRKVSKGKTMLSSKSTSGESMPIPSKASTPSRKRQCSNLIQKSPSRITRSMTRAGIATLEDIVEPKTIHEVPCETLLESRSEGKSSATIDVLNPSQKSHEEFDSSLVTSVEDSCCLKGNIASMNVNVSALSNSHIEEKTSKEMSDFLLPASTVSIASEEKSPCQEDNRLDDEPVVEDTEKSMDKYEGGSITHSTNDNIESSEIPALIPNSMLGDKCVDVSSKDFLVDKELDIMESHNLSADVSRKETRNQPDQYITDHSGYENDPDLSACKESSNSVSCKKTEDSENIHIVNDSGSIQQVLFFVEFVYSIFIC</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716822">
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    <evidence type="ECO:0000313" key="2">
        <source>
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    <sequence length="48" mass="5607" checksum="02C093D6F859732E" modified="2015-05-27" version="1">MRCLQLDKESIVYAIVDGGHIFYSSWFDKVDLANSERTKTMRRPSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHR4</accession>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XHR4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335850" description="DUF3456 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="20055" checksum="D8315140B8E31F1D" modified="2015-05-27" version="1">MHFVFLSFLLFSCFLLLRTASNNIDYPSKCESCAIFARDLNLLANRITTRSETSFIELMEKFCISMLNYKVHKNRSGLSRFSAKETETMEALKSLRSSGVKVDLGMPYEMWNAPAAEATVLKQDCELILALNEDLLEDWFLSGSKDPLEVLLCKERFLRSGEDNCLINEHLNHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHV0</accession>
    <name>A0A0D8XHV0_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJH43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XHV0"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC2_TM"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="235"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="575" mass="65081" checksum="BB43EDE18610A2B6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI42</accession>
    <name>A0A0D8XI42_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GOLD domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">DICVIV_09713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716487">
        <property type="protein sequence ID" value="KJH44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI42"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
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        <location>
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            <end position="206"/>
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            <begin position="167"/>
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        <location>
            <begin position="99"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23329" checksum="3298FA7B29656DEE" modified="2015-05-27" version="1">MIAFMRYVLTISLLSLSTSKAMHCFGNQSELPDAENHEVCLEVSYNEFRARGYADCSIHEFVVGFGDFKSKFRGIKNKESGLCMVRKMNETDFVKNLAVAAKIENERRMNESLENYERQSKVLLDNAKLHLLLLATGMTLTMGTQLIALRLFRKKLHDHYNESAYRQQYGSDGDGTVSPIRQSKSPSKSASKSTGSDAVDFYMIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIS4</accession>
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        <submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716696">
        <property type="protein sequence ID" value="KJH42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetylcholine receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900075">
        <property type="term" value="P:positive regulation of neuromuscular synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAPsyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46574:SF1">
        <property type="entry name" value="43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="13543" checksum="55D70AF382B50BC1" modified="2015-05-27" version="1">MNVANETNDKLLELQICVGLGSLFTLLKDLSKALIFIRNAMAIVQSVTIDDVHTKYRCTILYHLSVALRMRGSLVEAKEACDEALQLASEIGNRVLHARCMCSLADIYRELGESEAKETLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIS5</accession>
    <name>A0A0D8XIS5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_09415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulting in chiasma formation. During oocyte meiosis II and probably together with regulatory subunit ppfr-1, may regulate microtubule severing by dephosphorylating and activating mei-1, a component of the katanin microtubule severing complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. The regulatory subunits are likely to be ppfr-1, ppfr-2, ppfr-4 and smk-1. Interacts with mei-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="KN716464">
        <property type="protein sequence ID" value="KJH44550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIS5"/>
    <dbReference type="STRING" id="29172.A0A0D8XIS5"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH44550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="37371" checksum="49800D925B9454D9" modified="2015-05-27" version="1">MATAIADVAASEIRPDSPHTPGASHIEMTVDDLDKHIETLMKCELISEQDVKSLCAKAREILVQEGNVQVIDSPVTICGDIHGQFYDLMELFKVGGQIPDTNYLFLGDFVDRGFYSVETFLLLLALKVRYPDRMMLIRGNHESRQITQVYGFYDECLRKYGSAAVWKACTEVFDYLSLSAVIDGKAFCVHGGLSPSIQTLDQIRVIDRKQEVPHDGPMCDLLWSDPEDSSVGWGMSPRGAGYLFGADVVKTFCDTNGVDLICRAHQLVMEGYKWHFNDTVLTVWSAPNYCYRCGNVAAILELDEQLNKEFTIFEAAPQENRGAPAKKPTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ17</accession>
    <name>A0A0D8XJ17_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716527">
        <property type="protein sequence ID" value="KJH43779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ17"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF13">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31476" checksum="6AFD5676211F1F07" modified="2015-05-27" version="1">MPQDVVVGVSAAVISAVAYGSTYVPVRWFEIGDGLFFQWIMCIGQILFGIVVLATVGWPPVFPLAMLSGVFFASGNALTVYIMDGIGMAVGSLLWNTITCIIGWAVTRFGILGNPQQLPHHNVMNIIGVITVCIGAILLTLFVGSLYGNMMTPINYLMIKSAQTDTSFTNSSYFFSYCIGALLTSTVIFMIYSLIRFNRPFINPDLILPSIFSGIIYATATYCFFLANENLDQTIAYPILAKAPGIIVSLWAVFLFKEIKGCYDLTKLSVGISITITGISLIAISKIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJH4</accession>
    <name>A0A0D8XJH4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein Srb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein srb family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716660">
        <property type="protein sequence ID" value="KJH42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJH4"/>
    <dbReference type="STRING" id="29172.A0A0D8XJH4"/>
    <dbReference type="OrthoDB" id="5805206at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002184">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS BETA-1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00699">
        <property type="entry name" value="TMPROTEINSRB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="304" mass="35257" checksum="671E61E21A86F5F2" modified="2015-05-27" version="1">MNQISIDLECRKRGLDLVEQPLYRITQIFYVILSMTSIPSLLYVQIKYIYGSPFHQNIKIYGFTSSLITSKPCDYFSPNYIHIPLNICIFVANFGLILIHLALCCERTVATIRFSKYEHNGIVLGLILSALTVVGVLGAIFYVYDIEDFNEKLWSIIILPSASTKRYNKVAFANIIILISSVLLLSYLCKHLYWLSSTALPTSHWRIDSLFFSVHGIVGFFIRSPENRFLHVDHKLYIALRQLFYVIPIFTFVLPIYSVYRLKHYRSNRNDNMRSIVRMESRGAAGCRNYEEIIAKSWELSQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJW9</accession>
    <name>A0A0D8XJW9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KN716505">
        <property type="protein sequence ID" value="KJH44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJW9"/>
    <dbReference type="STRING" id="29172.A0A0D8XJW9"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28300" checksum="2BB9115A972F3E74" modified="2015-05-27" version="1">MTIIIVHIEIVAALVLVEAINLFHIFISYLLIFIAKVGLPAKSGVSGVLIVVIPNQMGIALFSPPLDKTGNSNRGVKFCKKLIEKFSFHNYDSLLHADSLKLDPRCRVGNRDTELVVSLLFAAKNDDIEAIRRMYLQGTNMEVADYDGRTALHIAASEGHEQIIKFLLCVNKVKHNPQDRWGRTPLEDARLFNHPRCAFVLETYCAKKSHSYTESDQIGEASDPETFSSTYDSTKDTSDYSSHLEIGSNGEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJX8</accession>
    <name>A0A0D8XJX8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716504">
        <property type="protein sequence ID" value="KJH44047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJX8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJX8"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="489" mass="54476" checksum="E6F36F27FBEAB2D0" modified="2015-05-27" version="1">MVQILLRLQLVPSRGNRSFIDGRQSRIRSIRNAGFYCRSVKYTNADGIRCCGFLYRTGNKLKACYLRLIRKEYPTLNSMLSNASEGSPVVFIVNPNFTLAVKTLGQFSKEASAYTSENKVDGLPAIVKSVNYSERHFTDIIHSQYYGWCCCKAFHYLILRPDLTSRSQYYGWCCCKAFHYLILRPDLTSRLPKAKVLTSADGFVPNASSYVLSGEDWSNMQSMAEKVLPQLKLPYTAVITATGGISTSEYFYRFSHKDRMKRVVTSDMEDGDSASDSSNAVGADINMPLSLPPYSRSKYPDVKPHRDGLGSCLLYMEGVNIVVQNNKKMFATIPIRSFVDSTTWNYAKGDVQCSNSTVGDYRLVFTGNTAGYWKLSKIEVKSLVVEPVSGSGQNFISNAAKAESGPISTASVENIGLNSVMGFAMACSDSQAAFFKTDQEGVLIGISFYNTEIQTFATYPDPKPQEMLYFTRQVEDCIGTFSTGSWMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKB9</accession>
    <name>A0A0D8XKB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716486">
        <property type="protein sequence ID" value="KJH44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKB9"/>
    <dbReference type="OrthoDB" id="5845707at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944:SF4">
        <property type="entry name" value="CPG4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36944">
        <property type="entry name" value="PROTEIN CBG02791-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="155" mass="17643" checksum="AFA2EA854AF98F3D" modified="2015-05-27" version="1">MAMQECRREINDSLVASNLFSITVMRKEQHNIRNHFESLCKRLGAMIECVEPVTRGGCGDKAAVMMLRFITVGFSSFEQLYAQLGISDQLPMSCKSLLSLRRRIPEQRLQIANSHHSDFSPQADTSAKFNILSFALFTFVLDITVINSVRYNIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLB8</accession>
    <name>A0A0D8XLB8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RhoGAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_08547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716409">
        <property type="protein sequence ID" value="KJH45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XLB8"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20818">
        <property type="entry name" value="C1_Myosin-IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000008">
        <property type="entry name" value="Putative unconventional myosin-IXa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046987">
        <property type="entry name" value="Myo9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184:SF5">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46184">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="564"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="810"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="878"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1093" mass="125810" checksum="5CFE97F01EF6CFE2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLP4</accession>
    <name>A0A0D8XLP4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_08499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716407">
        <property type="protein sequence ID" value="KJH45460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLP4"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="466" mass="54414" checksum="9D6E5BD05A983080" modified="2015-05-27" version="1">MRDLLEFYIDRRSFRPKGAPEYSLYPQIVKRWMKYEITKQKAELNTVDDENVMRVFEPRTQTVCVEVKEPLIRRFLSPSWNDTSLAFYLWTLLVCIGCLYNLVTIVIMVFEEARRNYYRLWICFNLAFDGVFLIDLLLQTRREATYNQWIFSYDKIPDPILIMCGVDNWTTENDCSTDIVPPLRIFEDHSNMTEEISKAMLYWENRKVDQFLQQKAKDYFIYSWSHGGGQVDEEEIAEFLPPRLYGQLAVHIHMETLRRVKLFEECEPNLLYELILKLELRVYSPMDDICRKGDVGTEMYIVKEGAVEVVSDDGSKVFVRLGEGTVFGELSILNIPGNKNGNRRTANVRSVGYSDLYVLSKTDLWEALREYPEAKSSLMEKAFSILGKSILAKDNMLEESENEMHVDEDLSVAEKLEAVSQSTCELAIQLNEAECRFQVFAERAKQLLFALEKEVDSELDQMHMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN25</accession>
    <name>A0A0D8XN25_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine carboxypeptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716372">
        <property type="protein sequence ID" value="KJH46053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN25"/>
    <dbReference type="OrthoDB" id="5849002at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="27231" checksum="61D6E6DD55CD2407" modified="2015-05-27" version="1">MFYTTGSRPPLWVAGDIVSCDFAYEQRALSLWARQKHPELITGAVGSSAPVVAELDFWRYLQVVEESIRSYSTKCAENIRKGFQLMMNLMNSELGREELSDGSYKLGYGISQVCDIMNNDVNDPLRNLQLVNKYMAMSQAMGAFCPALCLQAISLHGVASGNLAARILAGARSWTWQTCTEFGYFQSTDGGPNGIFGSVTPLSLFLNMCRDIFGPRFDSNYIANAVRSTLSYYGGAEGYKDGYRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNH8</accession>
    <name>A0A0D8XNH8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TopBP1/SLF1 BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716413">
        <property type="protein sequence ID" value="KJH45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNH8"/>
    <dbReference type="STRING" id="29172.A0A0D8XNH8"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000018">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057595">
        <property type="entry name" value="TopB1_SLF1_BRCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677:SF1">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23294">
        <property type="entry name" value="BRCT_TopB1_SLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TopBP1/SLF1 BRCT" evidence="10">
        <location>
            <begin position="584"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="694" mass="77257" checksum="3259BFB80B1EA599" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNU8</accession>
    <name>A0A0D8XNU8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716365">
        <property type="protein sequence ID" value="KJH46190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNU8"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
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            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH46190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="384" mass="43153" checksum="811052F2BD1CD5D8" modified="2015-05-27" version="1">MFTYPLDMRFISLYLGRRSICILCIAAGCIGCMCKIIPSFDILLLGRIFDGIFTGLLTSPFQQWYIDEHQVSFDFPSEWTHSTFLILSFGSGFLSVFAGITSQIIVSISEVLIIPYLMSTVTLIVGGFFISLQWKENRSVDAPLPFRNVIAKALGVIRSNPTTLLLSVTTCFAEMASQMYAFVWAPLFIQAQQNEVGSDYALGIIYASFAASYLTGLLIFFSFATKYRSSRLLLLSLISAFLVFVVATRELPFIHEDWTNIRFECVYLCMVVFEIACGVYTPAIETLQSTILHFLPQRSAVLALIRLPLTFLLSLSIMVFFPTPGGEMKMMIFIVIQLFISALLSLLLDAVVINRGYEQDPDRFFLPRTSAGEVRQSENTMISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPL7</accession>
    <name>A0A0D8XPL7_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SPF27"/>
    </dbReference>
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        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="23082" checksum="10E3D5E8A0B10672" modified="2015-05-27" version="1">MLALSGPTGLTAENDEQDSVDFQVLVDALPYLDTEYNDADRQTALRLIDQECKEMSKLDMSRCELPCPSGTSRAGDKVQWRKAIKNAKAQNEHLVTRQINLELMEEYAAESYLRRNRELEQLCTEAERELRRTKEQVMEIHARRKMAQLDAGRQLRELEGSWVAMVTNNYRMELANNQMAATNAQMAKRLRLDSSALEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ09</accession>
    <name>A0A0D8XQ09_DICVI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716339">
        <property type="protein sequence ID" value="KJH46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ09"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="13033" checksum="01763B951DD262DA" modified="2015-05-27" version="1">MKPSTRSLRLTLQVESVQHLIHTINHHLSASTLKQMRRIVAIREKSSMRQTSFLIHNELRMCTPRDSEEERKNVQNWSTTINDHINCIGYKHITQAFHPSVLKTQLRGQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQD0</accession>
    <name>A0A0D8XQD0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716338">
        <property type="protein sequence ID" value="KJH46720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF236"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21592">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21592:SF23">
        <property type="entry name" value="DAUER UP-REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03057">
        <property type="entry name" value="DUF236"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="33671" checksum="72F40F8B39F3E8CD" modified="2015-05-27" version="1">MNIRPPDEKKMVGVYDPNYQTLANMNNDDVFKRKDGGGGGMNIRPPDEKKMVGVYDPNYQTLANMKNEDVFQRKDGGGGGMNIRPPDIKKMVGVHDPNYQTLANMNNDDVFKRKARDGFGGGNNIRPPDEKKMVGVYDPNYQTLANMNNDDVFKRKDGGGGAMNIRAPDEKKMVGVHDPNYQTLANMNNDDVFKRKDGGQVQMNIRPPEEKKMVGVYDPNYQTLANMKNEDVFKRKDRVEGFIEGRAIPGAFVESPKPERYKQKNEPYRDFTYEDCYNNKKNKGGHGRRKRNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQQ1</accession>
    <name>A0A0D8XQQ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQQ1"/>
    <dbReference type="OrthoDB" id="5826491at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="672" mass="75734" checksum="396D5259F8E7613B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQX0</accession>
    <name>A0A0D8XQX0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <shortName evidence="7">LMW-PTP</shortName>
            <shortName evidence="7">LMW-PTPase</shortName>
            <ecNumber evidence="7">3.1.3.2</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Low molecular weight cytosolic acid phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="KN716453">
        <property type="protein sequence ID" value="KJH44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQX0"/>
    <dbReference type="STRING" id="29172.A0A0D8XQX0"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="17992" checksum="893CB329CB2DEDDD" modified="2015-05-27" version="1">MTTKKSVLFVCLGNICRSPIAEAVFLDIIKKRGVYDQWTVDSAAIIAFHSGKPPDRRALSTLRKFGILDYEHRARVVTTNDICDFNYIFGMDDSNMDDLRELEKQTRGKAVIQLLGSYDPQGHRIVPDPYYESGDKMFEQVYHQCVRCCEAFLNSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQY7</accession>
    <name>A0A0D8XQY7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_06806</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KN716320">
        <property type="protein sequence ID" value="KJH47098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQY7"/>
    <dbReference type="STRING" id="29172.A0A0D8XQY7"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF62">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="15">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH47098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="25697" checksum="C88DDE846442D052" modified="2015-05-27" version="1">MPLIWVRIQLLGLQTTHDNTEVVHKSDVIFLAVKPPHVNKVTSEIAPTLTREQLVVSIALGITIRNIESLLPTKSRVVRVMPNTPAVVRAGASAFAMGSACRDGDADTVRELLSTVGYAVEVPEVHIDPVTGLSGSGPSYMFAVIEGLADGGVKVGLPRDLAIKLAAYTLYGAAKMVLETGIHPAQLKDDVQSPGGSSVYGMHKIESGGLKGILMDAVEAATIRSRTTGDRALPRDIRNTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR00</accession>
    <name>A0A0D8XR00_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DnaJ homolog subfamily C member 16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Endoplasmic reticulum DNA J domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays an important role in regulating the size of autophagosomes during the formation process.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716366">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052460">
        <property type="entry name" value="ER_disulfide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44340:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335866" description="DnaJ homolog subfamily C member 10" evidence="7">
        <location>
            <begin position="17"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="41"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="586"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="745"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="863" mass="100072" checksum="A6A5F92095686C9A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR07</accession>
    <name>A0A0D8XR07_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716450">
        <property type="protein sequence ID" value="KJH44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR07"/>
    <dbReference type="STRING" id="29172.A0A0D8XR07"/>
    <dbReference type="OrthoDB" id="5798660at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9386" checksum="6F743DB7B622AA3B" modified="2015-05-27" version="1">MEYGHVGHSIFRLRRMFSEAVAHIRVVKAFQAGLDRREPSLAGHSAARLREISRQLRLQAESEGRGRSASRGNIKANEPNSTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR21</accession>
    <name>A0A0D8XR21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            </authorList>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        </reaction>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="6"/>
            <end position="66"/>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716371">
        <property type="protein sequence ID" value="KJH46071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUK9"/>
    <dbReference type="OrthoDB" id="5794962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF3">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="24549" checksum="35E96E86FF48E073" modified="2015-05-27" version="1">MISSTPLIIQLKINLTLTISIAIERILALSYPIVFRKLCNYSYTKYCLLFGCLLAIFDILLEFVLTPFERVPNCAAIGCFVSDQFRYYMGISNMMMGIIVIVLTTLILIKLRVVKQQPTNRGVWTNMKRRNLKQANRTCAAILFISLVFVTIPSVGVGFVEMIGYSIFRSIGPFYIVGLLCAGACNSFISIALNKNTWRIARDLISGHNTVSKVITPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV27</accession>
    <name>A0A0D8XV27_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716267">
        <property type="protein sequence ID" value="KJH48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV27"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="9167" checksum="7672BB5844F0D2C5" modified="2015-05-27" version="1">MNSKADFERETMNWEKTTELLWLVFQTQQPKMLVSLKSISSKARFFELSRFDFIVDDNLNVFLMEQFHKYRHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVF6</accession>
    <name>A0A0D8XVF6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_07607</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="KN716358">
        <property type="protein sequence ID" value="KJH46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVF6"/>
    <dbReference type="STRING" id="29172.A0A0D8XVF6"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="346" mass="37567" checksum="8B91B2779A2087D7" modified="2015-05-27" version="1">MCEADMWSKASFLTRLVASSVRISETAGNIIKEVMADGDLKIVDKSGQGEPADIQTEADRRAQFLIVNSLTERFGNINIIGEEDLTSECSIVEKSFAVDVLKVENDMKSDLKDIQPHEVRIFSRFSLLHNFSEKVSYLDCFCFHVVVWVDPLDGTAEVAHAVRNKDLALLEQITVLIGVAHRGRAVAGVIHQPYYGDNGRTIWAIKGCGVHGIVPASAQSRRTVVTTRSHLTQSVLDALAALKDKGLIDVVEKFGGAGYKVIKVLEGSAAYVFASPGCKKWDTCAVEAVLSAAGGHLTDISGREICYESTVQRNNTGGVLASAPWEYICSIPKSLKDQLPEIAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG2</accession>
    <name>A0A0D8XVG2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin conjugation factor E4 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVG2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVG2"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="6">
        <location>
            <begin position="292"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin conjugation factor E4 core" evidence="6">
        <location>
            <begin position="601"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="834" mass="95774" checksum="9FCED4C8DFFDC1FE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVT0</accession>
    <name>A0A0D8XVT0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716258">
        <property type="protein sequence ID" value="KJH48718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVT0"/>
    <dbReference type="STRING" id="29172.A0A0D8XVT0"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11474" checksum="192308720B203C8E" modified="2015-05-27" version="1">MAYIRWTALDRLDAKWINNRAIRRIFFFTTFTVTIISIPTLMVHKIIPVNDVLGTNDTQYNDLYTVQLDETDINGCTLFRANLWITETALKLASIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWK1</accession>
    <name>A0A0D8XWK1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 3-and 4-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWK1"/>
    <dbReference type="STRING" id="29172.A0A0D8XWK1"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="323" mass="36825" checksum="C6C4786F43CA0263" modified="2015-05-27" version="1">MKDMTLLNNFSAAKAPFLARFKVRRCGVRELERIGLEAQSREKGKSLPPWADLVELRKITDSCTCWQAAIFKVGDDVRQDMLALQLMQLMRNIWTALGLPVCVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTTYGDESSESFQVKDRHNGNIMIDLDGHIIHIVCNNDTQMTCFNETQDSVSRDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAPPFRQFATLCVQAYLAIRPYQNAFVSLVSLMLDTGLPCFRGKTIQQLRARFAPEMNERDAARYMYSVITNCFLNIRSKMYDQLQYIQNEIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXA0</accession>
    <name>A0A0D8XXA0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXA0"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="28611" checksum="FE9F889A31C0F07D" modified="2015-05-27" version="1">MLKSNGCLLVGVLVRNIHVLNEIVEVHPKWEWCIRMLALTVIIIRCGISLSWDHLEEAMAITLSLGFLTAVVESAAIAIAAIFLLEWSVPIALICGFVLTAVSPAVVVPVMLELRNREPLFEIIGVTVAELVIGVLIGLFVGWILWWFPISYVVNSSVCRTLLLATVTSATVLGGNVLGFSSAGIVSATLICFVAGVRWKTDNDDKAALAPSITALAVSTTDLKDEIHTAKSSIEDMHYIGKTSNGITGIGIKATKLDDAIQSQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXC4</accession>
    <name>A0A0D8XXC4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716268">
        <property type="protein sequence ID" value="KJH48414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXC4"/>
    <dbReference type="STRING" id="29172.A0A0D8XXC4"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF267">
        <property type="entry name" value="DEGENERIN MEC-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28980" checksum="A35985F31ADB3448" modified="2015-05-27" version="1">MASALYLRNWQDVLYVVRKCLRVMLFVNASDYLPTSEAVGVRLTIHDKDEFPFPDTFSYSAPTGYISSFGMRMVLVTVSQFSSYREMKKLLIEKMSRLPAPYGDCIADGATSSYIYKGYAYSTEALYLRCQQPCKQTIYTMSYSEAIWPSQSLNITLGTCEEEPEICNEQYKENAAMLEVFYEALNFETLTESEAYGVVKLLADFGGQLGLWSGVSFMTCCEFVCLVCELLYMIIQYHYKKYKVKKLTTKNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXC7</accession>
    <name>A0A0D8XXC7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NNMT/PNMT/TEMT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716244">
        <property type="protein sequence ID" value="KJH49160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXC7"/>
    <dbReference type="STRING" id="29172.A0A0D8XXC7"/>
    <dbReference type="OrthoDB" id="10050085at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
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            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="276" mass="31589" checksum="7F38273633F556F2" modified="2015-05-27" version="1">MVDTGDDQCADEMNEVYSAASHFDKVIASFQFNPNAYLESFYKTASEDSAMQIVLFFLPGILYRLPEKVKTALDLGAGPTVYLPIVLRNKVLQIYTSDYARVNRDVLQSWIENRSTFDWSEVCHWISSIEAVVEQPFAMQQQARDKVMAILEANVHETPVIRSVHWRRDNCEIPQRFELVSTIFCLEYSCETIDEYNRAVQGACSLIEHWGYLIQGGVMDATSYNFGGLSFKCHRLKRNHIEDALKANGMTVKPEEGFKFITHDGIFLLISRKIMS</sequence>
</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="10">HannoverDv2000</strain>
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    </evidence>
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        <source>
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    <sequence length="143" mass="16879" checksum="179DBDE101E2CEAE" modified="2015-05-27" version="1">MFTNHADLRRYFKGAENYTAEDVQKSERFDKQGQRILLAVYILADTFDDVSFFFCLLYTEIKNKKIAIYQEPTFRAYARETINRHRIYKMDPSLWGAFFTVFVNFLDSRGAVTDEQKAAWKQLGNMFDEECQSHLKALNLPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY13</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
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        </subcellularLocation>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">COMM domain-containing protein</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716255">
        <property type="protein sequence ID" value="KJH48797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15822" checksum="521384D82C026806" modified="2015-05-27" version="1">MNCYRNNTTLPITKADLPAEVKVALLEFVKNQLCETSSAGKIFDWNVCVVVGNNYVKKSLEVKVALLEFVKNQLCETSSAGKIFDWNVCVVVGNNYVKKSLEVITELNFDGEQLEFDTDMFGKLRHQLASAIVAMESYSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYK2</accession>
    <name>A0A0D8XYK2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="351"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="456"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="456" mass="50844" checksum="505A97EB11678879" modified="2015-05-27" version="1">MEQFDENTFFEQLETVMPKKLEALTIYGNYFPLKKSKKYGQWRKFEILFGSMIPQVRTKWWMKEECILMSHLVRSSPYKIFDDFRPTRNTAGSWRFDQASMDNENIRQERQNAPVNRILRFMQMFTLYEQNVPFYLSIGFDSFIERNSFLENKTKRPEGVPPAPIIAPRVLPEIPPPPRRERLRVRPNVPTVPEERSTAPIAIPPDGTMTAPVAVVMPVPPSQVVASVPTASQPPTSTSLSTAPVSVGQLTAPAMQTYSQVPTANLNISAQAQLPRSQDGVDQTRQNVQIEELPADTTTPSDQPQAIVSSPQEIAVVATQPASPDSAQTTSTPNLVVGAETPNSTEQQQVLQRNDVATFSTRSENVPRHGENDRNHVEENINMVLQGMLQALVEEIVFDAVNEDRMENPSTDPSPAVSSNATLSTTATPSTPSHHTQTATSQMTHHSQQQSNNTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZH7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZH7"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0140326">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH50068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17379" checksum="D5A979CE3C5A6DB8" modified="2015-05-27" version="1">MEPRTGRRRDSHDEQSADLLLLSTSEPHGICYIETMELDGETNLKTRCATPDTAEMGDDLDAISGFNGEIICEAPNNRLNKFQGKLIWQGRELPITNENILLRGCILKNTRWWFYYPYRTVSDCDVFDLYGIMWGVGMDNWSMVYRLSPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZQ7</accession>
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        <submittedName>
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    <gene>
        <name evidence="4" type="ORF">DICVIV_03902</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZQ7"/>
    <dbReference type="OrthoDB" id="5859671at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
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        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
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        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336216" evidence="2">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="223"/>
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    </feature>
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        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="25997" checksum="69F89AF3ABE56E85" modified="2015-05-27" version="1">MLPCFVIMELSLLVQITVHCDLLTSTSLQYHCIKFSDQYKYADALGLFSPSSDTGEYNEKVTMGLTSLLSMTVLLLMISENLPKTNEGLPILGSWRNDQKVPKSLMALARFQIFHRRIYRSDSYSDQYEVDDFCQPNGRPREKFVDFPRLQSSLARCEISTPTRSFENTMRLILANLQKKAAQKRLRIKWIRVCERLDSILLIFFLTVNSWFFTFILIVGYLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZV3</accession>
    <name>A0A0D8XZV3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_06056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZV3"/>
    <dbReference type="STRING" id="29172.A0A0D8XZV3"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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</entry>
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        <lineage>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">HannoverDv2000</strain>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="580" mass="65633" checksum="830846B69DC56940" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8Y0G8</accession>
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    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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    <sequence length="196" mass="22562" checksum="2ABE06D0B731807B" modified="2015-05-27" version="1">MKLYGFSEYWYSLDEVLSLGGNYNYTVISGKSKHFCSQRWSAIQVGAAVRRKLYRKANDERLKSQCFKSAWITAVLHDGFHVDREHNNFQSASNIAGQEVQWALGAMIYHMRYFPLRNSASNQFISRHAYDSSLPSASALWILVLAMLTMCGLFTVVILKEDISVGMRRNRSFWTYMMINSNDTSSYSSLRSIRYG</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16317" checksum="614E8AA615801614" modified="2015-05-27" version="1">MELSQAVITAHPENSLIRLNIKEQAYRTQEQKLKRTLHREGPMISLSRGEKRWRQQAGSTRIDVSLASFRTQMPLFKRREGCSIRERYEFRDVLGTGAFSKVFLAECKQEPGHMVAVKCIDKKALKGKEDSLENEIKVLRK</sequence>
</entry>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8618" checksum="EF36B378DFCF8111" modified="2015-05-27" version="1">MVTDFYVHQANTRDRLFGPETTKPSPKKVNPTFKSTIFDSTSPSSPQRTPKKTIPSLARNPITGEVKQQTTQQQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y221</accession>
    <name>A0A0D8Y221_DICVI</name>
    <protein>
        <recommendedName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y221"/>
    <dbReference type="STRING" id="29172.A0A0D8Y221"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="28773" checksum="117A931CF3F17AE9" modified="2015-05-27" version="1">MVYIVKVISVLCARTNLQRQAIAKSFKVLYGKDLIKGLGTKESLLIEILTSRTNQQIAEICQAYQQLYSRSLESDIIGDTSGYFQRLLVSLCAGGRDESNHVDHLRANQDARKLYNAGERRLGTDESCFNAILASNNYFQLRAVFDEYQKITNHSIEKAIEAEFSGDIRDGLLAVVAVARNRPAYFAKLLYDSMKGFGTRDSDLIRIVVTRCEYDMVDVRNNFQAMYKTTLEDMIKGDCSGSYKDGLIALVKGNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y258</accession>
    <name>A0A0D8Y258_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y258"/>
    <dbReference type="OrthoDB" id="5850281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336151" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="56" mass="6033" checksum="3D9DE82C8D94F6DC" modified="2015-05-27" version="1">MFERLLLCIVVIIALITLVTADFSCFFGDTICKSITCRGCTVATCLNGDCMCSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2A3</accession>
    <name>A0A0D8Y2A3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:heterochromatin organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="6">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="16537" checksum="CBBEF578B674D2FB" modified="2015-05-27" version="1">MFKWADYFGENNTLFVVDAKKKGNVGRFLNHSCDPNVQVQHVFVDTHDLRLPWSSFFAIRNIKAESLPQRGQGGRLERQTGSNKLYNECSFLWIFILLELCIHIKELCWNYGYSPDALDPDRPRHRQLFCKCGAVTCRGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2E4</accession>
    <name>A0A0D8Y2E4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_03531</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KN716209">
        <property type="protein sequence ID" value="KJH50337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2E4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2E4"/>
    <dbReference type="MEROPS" id="M01.015"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ERAP1-like_C_dom"/>
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        <property type="entry name" value="M1_APN-typ"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
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    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
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            <end position="225"/>
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            <begin position="264"/>
            <end position="485"/>
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            <end position="857"/>
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        <location>
            <position position="330"/>
        </location>
        <ligand>
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        <ligand>
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        <ligand>
            <name>Zn(2+)</name>
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        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH50337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="882" mass="102129" checksum="AD4791A0EAA23567" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2L4</accession>
    <name>A0A0D8Y2L4_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="21072" checksum="D96728F7F2AB0B59" modified="2015-05-27" version="1">MLDYVFRIVKISDNSSIYEYTQYISEDITPVNTQSKSLPNSPYVNTGNAVDNLISVQIDKACQSMRHQILARAFFGWLSYCRHLRTIRKHLMYLVTTREIIGEEETMTVDEEFWRRCRAEKTPELEEEFLFRVYWKGIEGINTKELRREAWPYLLMVCNWNEDLESKMTEITTKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2R8</accession>
    <name>A0A0D8Y2R8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bile acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH51000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336148" evidence="8">
        <location>
            <begin position="19"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="69" mass="7715" checksum="9D971891EABAF3A1" modified="2015-05-27" version="1">MVQKEWEKSFNCLVTALEYDLPQKSTTVISLSKSANFKEFQTKKSSGSWASMFAKLKLKEIDGIAPLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4C4</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Single-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    <sequence length="299" mass="34400" checksum="862E74A35C34979F" modified="2015-05-27" version="1">MALRMDISDILNEKYGSVNYVVLQLVFCIGGFFLYSMSESTWYCDTIDNTNKNEDIRYDPVSRIFQVVEFESRRESGRYDIYFIPRSREVGQSFLMALPMTIYSFLFSIIIVWKTRPDLLLVNGPGSCIPVVFAAALFDMIRLRDTIIIYEESICRVESLSLSGMLGFFITSLKGNSGIKFIMFFSTTFFYKVEIILKNRSTLLFHKDSFIFYLQGCRPDLLLVNGPGSCIPVVFAAALFDMIRLRDTIIIYEESICRVESLSLSGSIIYFLGLADGVIVQWKQLKEKYPRSLFINDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9A1</accession>
    <name>A0A0D8Y9A1_DICVI</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="261"/>
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        <location>
            <begin position="1"/>
            <end position="108"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="291" mass="32654" checksum="7FB57DA867B0D26C" modified="2015-05-27" version="1">MARSVSRARKAGSKSPARVKRQITSPKSEPKRMVSPITYLRSRSITRKFETPRISSPKAHTRSRSSSKGRKIKKGKASPGKSISRSKSHGRKMAIMNAKDPKISPKMSSKTLEKAEEELSLKTSAVKPRTFRSDPTKISYDKASAMDPTSNTKNVFTSTDRVPRLPERKIITSSYFQPEFRQRYIRNESSDRSPPKVTLRKPATSSCSSLYKRVVGTVSAVGGCVCDATCAACNKIVVNRREIFVTFALLLLVALMIYLILYTDPAKTRAFIHSIPERAHAFYQKHVSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9H5</accession>
    <name>A0A0D8Y9H5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic anion transporter, SulP family</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y9H5"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
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            <end position="88"/>
        </location>
    </feature>
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            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="34"/>
            <end position="339"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="392" mass="43462" checksum="0FFDF6BF3000911A" modified="2015-05-27" version="1">MAGVANDNVMSKHSGGFVEFLKNDSQLEIVTHFEVSPINIATTLTFSIGIWQILCGIFRLQFLMTYFSDPLVSGFTTGAAVHVFLAQVDDIMGVNVPKASGAGYIFKRLYDLATQVPHVNLTALVISLASISFLYIGKEYLSPSLAKKYKLRVPIPFELILIAITAALSSLFHWHEKSSLQIVGTIPAGLPHPDLPTFSILKECMVQSIAISIVIIAVHISMSKMLGKKLGYSIDDNQELYAIGLTSLLGGFFPVFPVSTALGRTMVNVKSGTRTQLSTVFSCALLLSIILWLGPLLKDLPKCVLASIITVALKSMFMKYGELRKIYPVSKIDFSIWIISFIFTVFIDVMEGLAIALIFALFTVIWRFQWLEYFLLPYDTQRGSKQKQIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9K7</accession>
    <name>A0A0D8Y9K7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-di-Alanine repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9K7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9K7"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="344" mass="39851" checksum="6DA6E9806A1EAD8D" modified="2015-05-27" version="1">MFINQKTLNIHSDEVHCPFYRLRVEKNPSGNHFQCYDEDCMKIFTTGEDRDDHCRKHHNINNVEFNIERRKLPKRVQKLEKTFNQMNLAPRRNRAGNLFKMAKLWKEGGDTFVKAAELHGAKGDSKHDCASQYAEAANCYRKVNPQLAVDCLLKTCEIYTDMGRFNMAAKTHVTIAELFETECPDVEQCIIHYQKAADYYKGEESKSSATKCLIKVAQYAAQLGQYQKAINVFEEIAMWEADHPTLKYAAKNHFFQALLCYLCIDQLDAQHALKRYEEASPSFTDSRESKFIKDLIACLEDGNEEMFTDTVKAFDKISRLDQWHTSLLVKVKKSINKDEEDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9L0</accession>
    <name>A0A0D8Y9L0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9L0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9L0"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019534">
        <property type="entry name" value="DUF2452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10504">
        <property type="entry name" value="DUF2452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="286"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="661" mass="74540" checksum="A4AEF8221C8949BD" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9M4</accession>
    <name>A0A0D8Y9M4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9M4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9M4"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF61">
        <property type="entry name" value="BESTROPHIN HOMOLOG 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="283" mass="33867" checksum="15D7107B48722381" modified="2015-05-27" version="1">MTINYNLAVSTSKPWTLFKLLLKWRGSIWKSVILELVVWLMFYGILSIIYRTALSYEQQRQAFITFKQVQGTYCELKWQVVIKEIPGQFIELRISSFFRTFERVVQYCDARLSYIPLNFMLGFFVTAVVNRWTALYQIIGFIDNIGLMTAEYVRGRSELARMYRRNIFSGFMMPHEKDRFDEIQYRYSKYWVPFQWALALTYDARQKGLIESDYYQVVVQEEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFIVCLLARQYIVSDNADKKTEVKLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9V2</accession>
    <name>A0A0D8Y9V2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9V2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9V2"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000065">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GH15-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="962" mass="110331" checksum="0550D4AFC6C416F1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAG2</accession>
    <name>A0A0D8YAG2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00149</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAG2"/>
    <dbReference type="STRING" id="29172.A0A0D8YAG2"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="543" mass="62694" checksum="E68CE5CBDDA1009A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAS5</accession>
    <name>A0A0D8YAS5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_00622</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAS5"/>
    <dbReference type="STRING" id="29172.A0A0D8YAS5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH53124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115173" checksum="FC2379C13D14DB19" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBG0</accession>
    <name>A0A0D8YBG0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBG0"/>
    <dbReference type="STRING" id="29172.A0A0D8YBG0"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24900" checksum="282C8BC9D41BF33D" modified="2015-05-27" version="1">MKFLPRLEEDKIDILINNAGVMMYPRYQKTVDGHEITWQTNYLGHFLLTHLLLPALEKAPKSRIVIVSSNWHLSSKSLDLQTIDDKAKFSLIEPYKRSKLANVMHARELSKRLHKQGIHHVCVNSLHPGIVNSNLIRSTIIAKTPLRQLSAPFRWLFMKTDRDGAQTSLYLALSKSIDGVSGKYFVDCKLGKESELALNDQACEDLYNYSLEQCGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC32</accession>
    <name>A0A0D8XC32_DICVI</name>
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        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716852">
        <property type="protein sequence ID" value="KJH41312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC32"/>
    <dbReference type="STRING" id="29172.A0A0D8XC32"/>
    <dbReference type="OrthoDB" id="6156898at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="30681" checksum="347567327D52891E" modified="2015-05-27" version="1">MREPVMSSRKIFRRFSSSISGALHLITIQKRNDACENEIGTALHGAVQMSNAVMTKNLLDNKSVWIDEEDGKGRTALHYSMEQNSFEVVKILVTAGANLDCVDIYGTTASHLACKEGRIDVFELLLQNGADAFCVDKTGKTPFDLACEYGKQKMVEYMLKNIENISLLQIAGDAHKISALHLAARNGHTHIVCLLLENGWNINRTTVNGTALHEAAGYGRAQVVRFLLHSIKRNFRLDWNKSVINECVRSYGIGIREEECASESDHYQRNTFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC44</accession>
    <name>A0A0D8XC44_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_11839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716700">
        <property type="protein sequence ID" value="KJH42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC44"/>
    <dbReference type="STRING" id="29172.A0A0D8XC44"/>
    <dbReference type="OrthoDB" id="8182952at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERM_domain"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26822" checksum="B1678D5376EC7E95" modified="2015-05-27" version="1">MKRNTWMYPLRFDDSSYIEMMYSQIIHDYLDGLLFTKNLNGELRNCTPDQISKLAVCIYLTTEEGMRNDITTHTVESLVPSVVFRSWSISTQCWVEKFKSQLERIGPDIRITHAKALFLKSLSNWPLFGYTMFRLKCVLRNRKEMKPSYLAVGKEGVKLIEEKSSVVVDEWSYNMIIDANVHIGAKSMEMLVYKRKATLAYDFLTDESSTIARLVSQYTVAVNKYEELSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC67</accession>
    <name>A0A0D8XC67_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716699">
        <property type="protein sequence ID" value="KJH42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC67"/>
    <dbReference type="STRING" id="29172.A0A0D8XC67"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="452" mass="50068" checksum="CEDB899E79DB4762" modified="2015-05-27" version="1">MLRTWCGSPPYAAPELLLGKEYDGLKADIWSLGVILYILVTGGFPFPGDNVENLKRAVLSCHMKIPYWVSVECADLIKKMLVIHPFKRLSINAVMQHRFVVKSSPLYRRPLKLNPTVLLFMQQHGLWTEEQIVDDVLKHNFESSIFATYEMLCDKIEKNSLKGLTNDYPRRGSRGSILSGKANVEADSLKATVSTHHLAQLNFSTSIECDSDDSSASDIYEESPSSSNNGKKQERCQFGLAMKEELGNRGEIRRHTLCASEKILSPDMMAQLPVSSPLYQAVLNHSAFTDLNTSPGGTNLVTSQLPLFFALPLMPMLDYAQMLPVPNSERRASAGENLLNPGTIESVNHIIHSAPTGNVARSIEEEGEGYLSKHAGKRNTVHTASSAFGPSSPAPRHCPYTKASSTERRSSWASPTITMQQQQQLERMHRQASNSEVLESSTVAFSDMKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDV9</accession>
    <name>A0A0D8XDV9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716750">
        <property type="protein sequence ID" value="KJH41834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XDV9"/>
    <dbReference type="OrthoDB" id="5850553at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7371" checksum="BD997C05029F6EA5" modified="2015-05-27" version="1">MQHNISSCAPLEGIISSSASALCDYAVDPLNGVWMSMLISLLCFVVMVIFSTSLVKLYNNMHSYPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDW9</accession>
    <name>A0A0D8XDW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717076">
        <property type="protein sequence ID" value="KJH40631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDW9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="33315" checksum="8827D5EF54329081" modified="2015-05-27" version="1">MDGLAGLSEFRQDKSVQARIAINPKQKEASHSQKKDQQHMLGSVVTFALLYCIETKQRKLTEIIPYVGMIDLGFVNDCLEQDILVAADWLESLLNADKAREQAELLKMLVDASTTMVEKIEAGELKLLHAAELNRVCNLIRLQVIDELIRRQPQNTHPVPNVEVQSHEHNSITTFYSHLLCHHKLYLAISSYIRKRFLERRFDSGSDIPSTSGVQNADYMSAFLPCSSKGLDIPSTSGAPNVDYMNTLLPCSSNGSDIPSTSGTQNGDSMNTMLLSSSKPGVSSAYPFSESSTSSGEISDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFC8</accession>
    <name>A0A0D8XFC8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MAP/microtubule affinity-regulating kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase par-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DICVIV_10655</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MAPT/TAU. Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5. Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ. Interacts with PKP2 (via N-terminus). Interacts with CDC25C. Interacts with KSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="KN716570">
        <property type="protein sequence ID" value="KJH43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFC8"/>
    <dbReference type="STRING" id="29172.A0A0D8XFC8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12196">
        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001032">
        <property type="entry name" value="KP78b, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
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</entry>
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    <accession>A0A0D8XGA4</accession>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="13">Calponin-homology (CH) domain-containing protein</fullName>
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        <name evidence="11" type="ORF">DICVIV_11126</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF28">
        <property type="entry name" value="BESTROPHIN HOMOLOG 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="30081" checksum="0187018419DE1B07" modified="2015-05-27" version="1">MPFRRDISSKIRLRFPTIDSFIHAGLLTQKEYEVLANLHEECETIRWMTPLHWIQQIMREEEEENKPSAALLNSFMTELKVYRQSLRKLFCYDWVCLPLVYTQVAALATYASFFFALFGRQHLIPDINAKNEIDLIIPIFTIVQFLFFVGWFKVGQDLMRPFGLDDDDIELNYILDRNFAISFAIVNRLQTVKLVEPENDQLWNNRERKVGSLPHSIYSCNLSEHRPKLHSYIKIPENDKEEVISCIKSYRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHN5</accession>
    <name>A0A0D8XHN5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_12179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716749">
        <property type="protein sequence ID" value="KJH41846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHN5"/>
    <dbReference type="STRING" id="29172.A0A0D8XHN5"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF105">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH41846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="48433" checksum="C22D9077A2ED60D0" modified="2015-05-27" version="1">MSPRIHCKCSGVFKSSSLASVDSNTAGKLGLISLIYYFITTMMAVVLGIILVVAIQPGKWSSTNVEEIVGEVSKAPCISNAIDTILDLVRSLFPENLIEATFRSHKLCMKFFNGTQSINPDHVLKMHPEDRATFTELPERMSSDGMNILGLVMFSVALGITIGMIGEEGIPLKAFFKSLETVSMKLISLVIWYSPIGITFLIAAQIVGMKDPGKELQRLMGYMITVLIGLFIHGFVVLPVLMITLARRNPIKYVYGMAQALLTALATSSSSATLPLSIKCVEENNGVDSRVARFVLPLGATINMDGTALYEAVAAIYISQCVGLDLTIGQIILVSLTATLASIGAAGIPQAGIVTMIMVLIAVGLPSNLFILIFPVDFFLDRIRTTVNVHGDSIGAAVVGKLCEKYLKQGSSNEHDDQGYSMLSTQASPDPSKRVNISKYHYENSHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI28</accession>
    <name>A0A0D8XI28_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_12034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716727">
        <property type="protein sequence ID" value="KJH41986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI28"/>
    <dbReference type="STRING" id="29172.A0A0D8XI28"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH41986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="40274" checksum="34357C67E9FD54AC" modified="2015-05-27" version="1">MGPRHILVGGGGGESKTGVSNLMQTYLLTFEKKAVLKCSTPMQAKLVGTIDTDVYATMNMDVVCYSNPEKGRYLIAAGHGQYCDVYETTGYSVGKDDSDKDALVYNIRNVGRLTTSEKVESFQKCVRFDHSTAGKRVVTGGEDGRVRVSLLFKNPETVHQPILDIEAHKSDVFDIDISLDGRVIVSVGHDGVAKMWDMNLGTLIQEVPFPTECKSGYKVRSIRCTPLGSGSNLVFVAGYNPVSLSAKHVSYLSLWAYSRERQSLRIVVLRSTGQADNTHGIFVTAVEFLDRTAPDVLSLVPQPTSGNPRQIPGPGSCARASIISLSADQTIQVHNLLFDTSSTSLFLIKLFFISTVVYYVIWYISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIC3</accession>
    <name>A0A0D8XIC3_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716482">
        <property type="protein sequence ID" value="KJH44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIC3"/>
    <dbReference type="STRING" id="29172.A0A0D8XIC3"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF420">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="304" mass="30988" checksum="87EC3A8B804AFB9F" modified="2015-05-27" version="1">MEWIPCSRQATFTATVLSTVSIISVIIGLPIIHLHIQKVTSVMLMDVDLCKSESRDIWKQMSFSRPGDIRTRRQSPYGNYGAIPAGSCCACSQGPPGPRGAAGADGQPGNDGFPGRPGVNGRNGKYLPAPPPGTNACQKCPLGPPGPPGIPGPKGTRGPAGKPGTPGRPGEDNRPGPPGPAGIRGEPGPPGPKGPTGDRGKVLNGAPPGPPGPPGKVGPRGPPGGRGQDGKPGQPGNQGIRGAVGDRGDPGNPGLSGPQGPKGEPGMPGSCSHCQQTAPQEPPKTQRNEQDYVSEQPKEYLWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJE7</accession>
    <name>A0A0D8XJE7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Initiation factor, subunit 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716513">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJE7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="237" mass="26799" checksum="089D9698787ED401" modified="2015-05-27" version="1">MERVVNGPIPADFMSNFDNRIKSFRFDVGKNELLVLDQLLLPHKIEYIPIKNTKDAFTVIRKMQVRGAPLIAIIGALSLLVELTELNFTRNDDLILFIEEKVKYLLSSRPTAINLQNALDTVLVASHVDGDASSKKNVLDSILKLLHDESEENRRLIWNGYQEILNIKNPSSKFVLMTICNTGSLATSSWGTALGVIFSLHQANHVEMVFVLETRPYNQVRCILTYFSLLCSMSVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJK4</accession>
    <name>A0A0D8XJK4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716452">
        <property type="protein sequence ID" value="KJH44733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJK4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="46" mass="5169" checksum="C4EA1F3D536EDF72" modified="2015-05-27" version="1">MKISSSYARDSSTATSAHLPIAATELLKNLQLCWKLFIMCRPIRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV8</accession>
    <name>A0A0D8XJV8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="29794" checksum="ACD5BF81CA00F0B8" modified="2015-05-27" version="1">MFHVPCLGVLTSRCILDECRTNHLLEEVDESDITFNLASFPGTSFPCLFTLSFLTLPFVILYSCKRLLFYSDISILFLDINLYSCAIISTFVVLWFVVKWRLKVLIHSLNALECSARKANRLLRERETLAFGLGLQSLRVHSACRLQLLVCCRETILLMSAFSKSLISTDFMFEESERLLSVFYTDEMYDLVHADISSDSFHLSQRGIEFSHVTREICESMENKGKSGPGFIAKHGFRTFEPVPLIINVIRNSTYRYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XK10_DICVI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="452" mass="52210" checksum="9661A26734DD6FE6" modified="2015-05-27" version="1">MAYRWLQSTRHIFPSAREYLQAYHRLLFMERVRLPLLLPEVYCGLEQGPTESEFMACFKIISECHLRESILGDHITMLDSQEAIRLIEGLTKRAVENRVSSDDNLPLISFSNPVQLIDREEFCFAMKKYYWKVWYIVMMWSCAGKVGEEMEKIYNRYPQLRLFIHMVLVKSFRFPLEFEGKTPEEWEAMEAEMVKKEKEAILSMESFLMKQNIDEENSRFIGTLCFNHPRAIPRRPPEPFIRKLEALALDCSMASRLCECRQPDMVDQLIRNVGPSKAMPAIQKTAHYLLKELFATNASAIEAMPVSTLCQFLQYDLQHRKSSNDVESNAVHTIVARVRAAFADDAVQDDCVSAVLFLLDRRTAFNVRERLGAKLVLTNLFVNTDELMVLNQGTEGVWMEGLRHAPFYRKIAPHLAIQLAKAAVDSEGLQLDCILTTIRQEINKNNMHQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK51</accession>
    <name>A0A0D8XK51_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glutamate receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DICVIV_09763</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716490">
        <property type="protein sequence ID" value="KJH44219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XK51"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008328">
        <property type="term" value="C:ionotropic glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:glutamate-gated receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000241">
        <property type="entry name" value="Glutamate receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000064">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="23">
        <location>
            <begin position="3"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="19">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="19">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="54946" checksum="0836A6407EF66FEE" modified="2015-05-27" version="1">MTKRECMDQNNRTECKGNNKFEGYCIDLLKLLADRIDGFNFEVYLVDKTGSKLPDGSWDGMMGDLLNGHADVAERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETARGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQTKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPSVFVSSYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGVATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDQGITLDGSSASLNLSKVAGIFYILMGGMIASMIAALGEFLYRSRIEARKANSSSLVGNFAKSLKSALSSQLRLSIKGGAVALPGSQSYDALKRQQAASFLPASNSKEKNDDGTVTDRDSRMSSTFTYNTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK54</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XK54"/>
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            <begin position="1"/>
            <end position="57"/>
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        <location>
            <begin position="1"/>
            <end position="14"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="8861" checksum="BB099E039C1F291B" modified="2015-05-27" version="1">MLLSNRSTSTYESEITNDENTPLLNSSSSLPTVTSYDNPLLDFPGPSTAYSETNECEVVNRGQRRRCTAQRPMIKQKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKB4</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22718">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="311" mass="35548" checksum="6BC944A32E60C26B" modified="2015-05-27" version="1">MDEEATTVIRTICAGLILLPTVIGLTIHLIVLTALYKGRKIFYKNSFYLIITQIIGCNIYSLFLLLYIAFPIILTGVQYMGDSFVFYYGPLFLESVTFSGMVLLTFLLTINRLTIFILPKLNVVLFTVKNTLLISGILWLYNFALTTSIEISGCKKLFSKDEFYLWDDCTKTINGGFMLIQTYQELLLTSLMCFIYVTIYIKIKISQKYSTNAFKNEKVFLIQTIPLSVILAVELLAFKLIPMLNVTDNRRLFINISGSLLIILVDITSPILLLLFNKDIQKFASDIFFSSLFQSPSSLSRRHIQSFLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKE2</accession>
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        <name evidence="2" type="ORF">DICVIV_11235</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9042" checksum="147794D1727CBFF7" modified="2015-05-27" version="1">MHNIDKINRIVPASVIIVILVFALMFNIIGTTLLFLYRRSEARRMSILGCAVISLLASVIDCGVIGLFVKFPPVHGTTSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKM1</accession>
    <name>A0A0D8XKM1_DICVI</name>
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            <fullName evidence="12">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="12" type="ORF">DICVIV_09669</name>
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    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Strongyloidea</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKV8</accession>
    <name>A0A0D8XKV8_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
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        <name evidence="4" type="ORF">DICVIV_08707</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 10 N-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Utp10/HEAT1 HEAT-repeats" evidence="3">
        <location>
            <begin position="780"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115369" checksum="0BB5583606C88692" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLD3</accession>
    <name>A0A0D8XLD3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716584">
        <property type="protein sequence ID" value="KJH43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLD3"/>
    <dbReference type="STRING" id="29172.A0A0D8XLD3"/>
    <dbReference type="OrthoDB" id="10062843at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
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        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118896" checksum="4DCE1F38B26949EA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLN9</accession>
    <name>A0A0D8XLN9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716407">
        <property type="protein sequence ID" value="KJH45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLN9"/>
    <dbReference type="OrthoDB" id="5867860at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="38929" checksum="3B7D6AE50AC95B8E" modified="2015-05-27" version="1">MHPPRHRTRLSYDKGRCVPVGWKPLVVDSRVRNYIYARAKRTCLEARDREAQRRAAEERQREQQQMRERVDEDLEACEAELERVKARRDELAAEKHECFTKLKACLQRESMQKKAEDEKKRRELLTLQLQQPFLAATIQAQAQVQAQAQANSLISNQHLLTQQNLLSQHFNAQSLLNQQALLQHQQLLAAQKLQELAQAQRGLVQQQQPSVAQPTPQQSLPAGISPAYLQQALGQVQGLLPGVSASVPTFSASSSVTGSTPPLVFGQFVVEPPKQVQASTSQAPQSHIKLEVPSPQVSPAPQTLNQQSYGLQNLSSSFLSNSNPFFTRALTNNRQDYLKHLNESNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLW8</accession>
    <name>A0A0D8XLW8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_10618</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KN716566">
        <property type="protein sequence ID" value="KJH43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLW8"/>
    <dbReference type="STRING" id="29172.A0A0D8XLW8"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="370"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="612" mass="68922" checksum="886A6764553E9707" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM90</accession>
    <name>A0A0D8XM90_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cullin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_09032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716439">
        <property type="protein sequence ID" value="KJH44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM90"/>
    <dbReference type="STRING" id="29172.A0A0D8XM90"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000022">
        <property type="entry name" value="Cullin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="11">
        <location>
            <begin position="415"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="775" mass="88621" checksum="58868DCF7E0675C0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMJ9</accession>
    <name>A0A0D8XMJ9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_08986</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716436">
        <property type="protein sequence ID" value="KJH44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMJ9"/>
    <dbReference type="STRING" id="29172.A0A0D8XMJ9"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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            <name>Mg(2+)</name>
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    <comment type="similarity">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716389">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="4150at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="19991" checksum="387C616D93A2D73D" modified="2015-05-27" version="1">MNAVYFELDHEDHELARSTRMSSVIWSQDVDDDGLPKDYKLKTLKTGSRRLDTFVNRASGKSSMETAKCILSGRVRVNENVVTKKSYNVQINDNIDVWIESYPENTRLAEVERYEVQINDNIDVWIESYPETTRLAEVERYEVVNYAVTDKGYDIHIKSWKKFVVDNWRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQA3</accession>
    <name>A0A0D8XQA3_DICVI</name>
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            <fullName evidence="3">Regulator of G protein signaling domain protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">DICVIV_07098</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716333">
        <property type="protein sequence ID" value="KJH46823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XQA3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF254">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="18599" checksum="D721BE0F09E6F2FF" modified="2015-05-27" version="1">MRLPRNLLKRLSLRKGDRRPRSTDGNGTSLSPGDGSSPRLSPNEWQFAFDHVISDTDGRAQFTKFLQSEYSEENILFWWAVEELKAVYASESRSEFERTVLEMFETFIASESPLAINIDHDTRTDIMDRVENRDPSSFPDNIYDRAQAHVYRLMEKVSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR02</accession>
    <name>A0A0D8XR02_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716451">
        <property type="protein sequence ID" value="KJH44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR02"/>
    <dbReference type="STRING" id="29172.A0A0D8XR02"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="NSF_attach"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRH2</accession>
    <name>A0A0D8XRH2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="205"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="534" mass="61054" checksum="F6C072604CA3D1AF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS15</accession>
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        </submittedName>
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    </gene>
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
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    <dbReference type="EMBL" id="KN716308">
        <property type="protein sequence ID" value="KJH47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XS15"/>
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    </dbReference>
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        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
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    </dbReference>
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        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF16">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336156" evidence="7">
        <location>
            <begin position="22"/>
            <end position="550"/>
        </location>
    </feature>
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            <begin position="523"/>
            <end position="545"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="550" mass="64290" checksum="FB09AA544130806B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSC4</accession>
    <name>A0A0D8XSC4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716417">
        <property type="protein sequence ID" value="KJH45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XSC4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="385"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="487" mass="55685" checksum="1328928BC788FC30" modified="2015-05-27" version="1">MCLSYLTIAYENDRHLWAFQTILWRQLWIWLAESQLELGLKQITPEAIEEMVKMRDNIDWHKIREEEYRLKHDVMAHNHAFGAICPQAAGIIHLGATSCYVQDNADIIVIRDCVRYILRRTAIVLDRMARFAEREKSRVTVGRTHYQTASLVTVGKRTVLWAQELLMAFKQLERFHDTMKFRGVKGATGTQDSFLTLFSGDEEMVHLVHFHVSQLCFFLVLFQVEKLDELVTRKAGFDQKFFITGQTYSRQQDVQLIFALAAIGAAVKKICTDIRILQAVGELLEPFEKDQIGSSAMPYKRNPMKSERCCSLARKLIHTPQEALSILSDQGCERTLDDSAGRRMLLPESLLTAEAMLTTLQNVFEGLTVQVENVARIVKEELPFLGLEKAMMWLTEEGVDRQQAHAVIRTTALEAKQKQTLGFVSMSDVLQDSFFNSVRDRVMALVDEPILFTGRCVSQTVRFITNELRPAIEPYFDSSAPEVLLNV</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <sequence length="321" mass="37241" checksum="FC087AC8E8CE9B57" modified="2015-05-27" version="1">MDLPHEVVYHHHLPVEAEEDIRMMEDQTDVNMDGGLTEPRAVHQCNICNKIFVSFKGLQQHAVIHTDQKPYQCDICSKSFRFKSNLFEHRSVHTGFTPHSCPYCGKTCRLKGNLKKHLKTHVTSKDELERAWRPFACNRRPAADIPDDAIIVRGTGDPFFTPPSRPRKKKLGLGPDPTAWIDKIRRGEILPGTSIQTKMMRLETVLKNSEFSIEEIFEQARTIAFEKFDCPMCRSQFFSRAECYDHLEIEHPMARIERPLFCEICLKVFADRKSLEQHESYHKRVHLMLDNNEIESTDPEILLPESCEFDEEDLQGVPVIH</sequence>
</entry>
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    <accession>A0A0D8XT64</accession>
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    <organism evidence="3 4">
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        <name type="common">Bovine lungworm</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716296">
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126738" checksum="20A832A81D348397" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716324">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="26142" checksum="59D174125E2D5B0E" modified="2015-05-27" version="1">MLPSSCSSPFGSHSSEVRGCVKKAQRDAMVDLVTSTIDMFLSRSCDEPQVLSIRVPDVNVTVAEVTPTEASKMVNNPHYDKLLEAAENKKRVHAACAAARQFLVEHSMAKNPFCPSAHKTHGVAAIQPKNDKVDLTFKDSKGKIRRRQAANVLRPGGLLSSTNTSSSHVSTSSNILKVARPTSSSYSKSSRSSSKSSDKKTKSLDRSTKSSEKSSKSLGRSSKSSEKTSKSLGKKDRQQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT99</accession>
    <name>A0A0D8XT99_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT99"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12805" checksum="A79CFB90C46806B2" modified="2015-05-27" version="1">MWKLLTMTLRLKKHAAKSENDITRLRQCAFIFCQCSTEENLLLLVEMTCWFYFYYFPQRRLKFHRQNSNCRELMKNGLYKELCGSSDESKSLMKELHEFISVTTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTA2</accession>
    <name>A0A0D8XTA2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716398">
        <property type="protein sequence ID" value="KJH45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTA2"/>
    <dbReference type="STRING" id="29172.A0A0D8XTA2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="187" mass="21434" checksum="CD3BBE103940C6DB" modified="2015-05-27" version="1">MFVQSNDDKIIQGEVIVNVAASIALMIYNARKKLQMDTSNTVPSTSVTSMTDPLRNVSASNDVTQNRMHWSKSLNRRRRTKFSPSQLQVLEEVFSQQQYLVGNERSRLAAFLNVGIVQVKVWFQNRRIRWRREQRRGTMVASYCRAFTTPTTSSAAKRNVGAAASEQAHEINRMAKKFCDRIFLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTL0</accession>
    <name>A0A0D8XTL0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lebercilin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716393">
        <property type="protein sequence ID" value="KJH45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTL0"/>
    <dbReference type="OrthoDB" id="5877253at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36766" checksum="BFA0127B14E5307B" modified="2015-05-27" version="1">MNRGRSPRQEKLDDMREELLKAKKVNAQLILNNRILNTKLQRLTREARKHDQSQKTQYEGKASVNMESKTSTAVRSAKELRSATVIGDRLESAAPNVQELMREISAINIETITPHAHQDAELRELKEKNKRRLRMAKAYAEQNHKLKQRLKQMREQMFAQQNKQHQSSIAIATRENVGKNGSYNRALMERLNEAEMKMEYLRNENDKLKRNLEYLQARTDSYFLGNSSEKATESPNVALSIPQRAGEAVIIPPLDICRGSDSISSTERLSSRSSSNHVLGSNRQCEDEISMNVLLYVVVELAIAYSERQLILQELNDVQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTV2</accession>
    <name>A0A0D8XTV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Troponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716287">
        <property type="protein sequence ID" value="KJH47955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTV2"/>
    <dbReference type="STRING" id="29172.A0A0D8XTV2"/>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030172">
        <property type="term" value="F:troponin C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000005">
        <property type="entry name" value="Troponin I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF41">
        <property type="entry name" value="TROPONIN I 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="27220" checksum="B37AE22733B152F4" modified="2015-05-27" version="1">MLTRCAPVLSSILAPLQKQLCKPVVGIKAKQSICNWSLSLKLDKATDRVKRLAERERKKEAVRKRLEEASRAKKAKKGFLTPERKKKLRKLLMMKAAEDLKQQQMLKEQERQRVLQERIIPLPDLDECDDLEEVYNQMRDRLIILESENYDVSYIVRQKDFEINELTIAVNDLRGKFVKPTLKKVSKTEGKFDKLKKKEASKVDFRSTLKTIEKNQFAMEEDGKEKAKADWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTW3</accession>
    <name>A0A0D8XTW3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="KN716385">
        <property type="protein sequence ID" value="KJH45811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTW3"/>
    <dbReference type="STRING" id="29172.A0A0D8XTW3"/>
    <dbReference type="MEROPS" id="M12.A19"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF818">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005115654" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="92"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="361" mass="42067" checksum="581E96CD4E1D09B3" modified="2015-05-27" version="1">MLFNVALLIYLRFILAASSSVSMQDIIDNTKPDEETVLTEDDFRSFHSEDITKLGIKVKDDPTMGNKMEGDIVVENPRKPINNDNSNRYGRSAIRQAYRKWPNREIPYALSSKYGSYARSVIAKAMQEYHNKTCVRFVPRDPIRHVDYIFIHPDDGCYSLVGKVGGRQSVSLDSGCIQVGTIVHELMHAVGFFHEQSRRDRDEYIEIVWRNVQNGADDQFEKRDRDEYIEIVWRNVQNGADDQFENEIYFRYNYNIIDHLNEEYDYSSIMHYGPYAFSGSGRKTILPRKGGAERMGQRIAFSEGDIRKINKLYRCNDSVHRNSLTDNDQTFYELTPITTVSTDRTYLFNIIANRFGRIWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU50</accession>
    <name>A0A0D8XU50_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716315">
        <property type="protein sequence ID" value="KJH47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU50"/>
    <dbReference type="STRING" id="29172.A0A0D8XU50"/>
    <dbReference type="OrthoDB" id="10055367at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="189"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="518"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="720" mass="79740" checksum="84A5AF101B312F6C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU60</accession>
    <name>A0A0D8XU60_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the globin family.</text>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="218" mass="26179" checksum="184D4E021E825738" modified="2015-05-27" version="1">MKSTRRMSESNKAELVAKQVDDEHSVSCRKVMMSNHKTKHQKYENILQWQPNVNERQLLRLTWSDEFEFLYELGTSIYSYIFENNPNCKQLFPAFNKYGDDWKESREFRAQALRFVQTISQVVKNIYHMDQLEPYLYNVGQRHCKFVQRGFKPEYWEVFQDAMEHSLTEHMNKLPELSDQQRIEAVQVWRTVALYITTHMKIGYFDGLKSINRHPPLT</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
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            <end position="134"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="326" mass="36568" checksum="1B47396BBFFBBE4B" modified="2015-05-27" version="1">MNSCVYVKITSKTAPGTIIGEVHAIDADGGIHGIPTYRIEPPNHLVTVGRNTGLISLTSRPETQRNRTIERIMVIASSSYTQQSSATVYIEISDFWLREEYMSFSSNIFTIGVVVMVVLTMLLVCLLGCCLINYRLSKPKEVDSPNKQIYTVSRYRTSTFANNNVQHLACSTVQDLPSNILEKSSSTTSSALSNSVQRNSLTYHRDVTSTRSQPDSGIDQDAVSVNSSITEYLVSIGLNPNPKFSKQRLQKPDTIDSALSEYIYAQLDEIPPSEPHKVSENVHRPEELYPPPLTAPTFRPLSEIFDELEEMQRERPMEREYVQVEI</sequence>
</entry>
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    <accession>A0A0D8XUI3</accession>
    <name>A0A0D8XUI3_DICVI</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716308">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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            <end position="93"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="336" mass="38532" checksum="6A1D88AA7C585289" modified="2015-05-27" version="1">MISLMKFFDDLRAHLQALPLKSRPDVADRIREAVRQHCRELRICRTAPLNRLIENVCVARESELWSFIDVEAEMTLDGAIDSDGSGSGSDSSGSGKGQRPRRIHTFHGTTCQSGEPNAPAPTREKSAIRRHTTVPRMSSGQDYSGDRIEEDEERYELNESRREQLEVDEKLHRLPLGLNLKARRAMTHLIRDVVKLKSENNHLRNEISLSKTRLAMKERTQHVIMPSALASDTMEALRRKEQELREENAKRRGELEQWAEQLRVEQERQQKQEIQMQLEREQLRRNEVELANKWAALHAATVGCSGVPESRIVGRISMKSPSSLNKTSSFRDTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XUZ3_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716298">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MPP6"/>
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        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="248" mass="28928" checksum="E267D89B41A32F5E" modified="2015-05-27" version="1">MRDATGQLNIFTEKYRENILNYGSGGDPLKKLEVHQFPFNPLYTCPHTPNYRRLMSEKCKKLSSTVLEMKFMQRTKKKMEARQRKKQEAETRENLGSDEIGVSERKQSRFQYSNNLAYLQSLRFGRMSFGGCNPEIEKLMLYYGRKTEDNSDKDSDNGKDIEDRDMAKALVLDLKMKIGFLSEFFCLRLRHNTSRKLNLRESEKLAASTFSNLSEISGAKLNFVDVRKRGARDTWADLSSTRKHRKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW98</accession>
    <name>A0A0D8XW98_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW98"/>
    <dbReference type="OrthoDB" id="5870197at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45217" checksum="D4A99D877C39DE6E" modified="2015-05-27" version="1">MLPSIHYTELSEVFYEVKDEGNTFVQKLMSVISNDRICNDVQAFDTNYKSGKECCASPLLRYILHLLTNDSRKENLCTWYGGPFGVRIWDTKEFTESYNMAMGTNMNFTNISRALQSCEHITIAGNRLWKRIKQGEYSFFPTYKGHGIPPIPPSAMPRNVPTYFPFERYGIVKAPHSRLKMGCDGIDSASTHHHTEVYYPSFSKQIHHHDFLTNRRSPSSPLVNPTLLAPSHMYSPCNVESSTWSVAPPCFVQIRNILPTPPSSDTSPSASDSLYSNESLLSQSHSSVFTPSHKSYENQYLIQQETADKGTAETIENEQRLVDSFDAAILSEFLVPVDNTPSQTLDSSSSPHESSTFVFDNNLTNHNDNTFNVFGVHQDIFGNISSTDGLSLTIDETSLLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWA7</accession>
    <name>A0A0D8XWA7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWA7"/>
    <dbReference type="OrthoDB" id="5824604at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182:SF1">
        <property type="entry name" value="COLD-SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35182">
        <property type="entry name" value="PROTEIN CBG13762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="14975" checksum="F987F226BBA991E9" modified="2015-05-27" version="1">MIRIQIYLIFSLISCAFASLAFYNAKAGDRVVLDLGKDVQTWMRVRDSDIEEFIKYCKVGDKEPRCFGFVTEAGKPTTPKSNARVDKDGKLIIDPVKLSDAGTYSSPDQKPILKKNRNGGVSAVLNTQITLEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWN4</accession>
    <name>A0A0D8XWN4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Spectrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_05671</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716275">
        <property type="protein sequence ID" value="KJH48207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XWN4"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21194">
        <property type="entry name" value="CH_beta_spectrin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="15">
        <location>
            <begin position="131"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="737"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1220"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH48207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="3564" mass="415203" checksum="81BEED8BCA0331F5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWS5</accession>
    <name>A0A0D8XWS5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716275">
        <property type="protein sequence ID" value="KJH48209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWS5"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052861">
        <property type="entry name" value="BPTI/Kunitz_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248:SF6">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47248">
        <property type="entry name" value="PROTEIN CBG06772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336269" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11397" checksum="634FA32D463C588B" modified="2015-05-27" version="1">MYMLTLLMLSAVILVAGGRFPHPPVFAAPQHYPSICYLPPDSGLCSESTSSTEENTELLTRYYFDVTTDQCYPFGVQNCGGNENRFKSRVECQNFCRIDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX18</accession>
    <name>A0A0D8XX18_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, C3HC4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX18"/>
    <dbReference type="STRING" id="29172.A0A0D8XX18"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24948" checksum="835AB734A265BDFE" modified="2015-05-27" version="1">MSYVYSLAGPIVSLIFLIVIISILFRSHLMYFRYIVKKVKNRHKQVRKKKDVHIEQEKTTDYMKNQIIRKSKRISKASCFFDESLLVCDICLEVMHNAMNVSPCNHKFCAGCIYEWNSFNSKCPKCRWGAADITRDTTLNSIIEQYLIAFPEKKRDAAQLIELDERELDHLEKWERKRDTGEGDFEHGYFEVNFLIFLFFWWVERNSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXE5</accession>
    <name>A0A0D8XXE5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716324">
        <property type="protein sequence ID" value="KJH47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXE5"/>
    <dbReference type="STRING" id="29172.A0A0D8XXE5"/>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="506" mass="57584" checksum="42E2317CC42CA43C" modified="2015-05-27" version="1">MRRQNPRRDETEQQIQDNEEKNKNEGRRNWHTTLKRIKTLSTIVRKQRERRKQLKKTLQKMIANSPEKFQDPLKIYAVQQMQMEDEKLLMKKKLTSQKRDEIRVPMKLLRDSIKMQMEDEKLLMKKKLTSQKRDEIRVPMKLLRDSIKLVLAASGKNVTKFDKKTVKLASPRLLSVVPEQDDEDLLNILSPSLFSLHEDGTEEEKSMSLPNLLKELPNSDQEAWLDFITEAAGVSDTVDKAEKEYKKLAEKDMMSFDEEPLYLKKENVSDLLGSTERRKIETFEMLDRSYTIDQKIHRRHENPHHLIERDIRALAEAKKFRVRQKDITLSPFVLTPLTFAGQALSQTITLSPLLLSPITLSPAVLGPIILSPWVFVPLVLSPRVLSPLVLSPLVFSPIILSPLVLHPLILVPGIFNPLILSPLVLSPLILSPQLFSPLILSPMVLNPLILTPIAGSPLVLSPFLLSPIIGSPLLLSSVVLSPYALSPLIESKLVTSEVILSPSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXP6</accession>
    <name>A0A0D8XXP6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05289</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716262">
        <property type="protein sequence ID" value="KJH48602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XXP6"/>
    <dbReference type="OrthoDB" id="5838555at2759"/>
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    </dbReference>
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        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
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        <property type="entry name" value="GROUNDHOG (HEDGEHOG-LIKE FAMILY)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967:SF24">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotid_trans"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="345" mass="40399" checksum="C1E287E56AD66826" modified="2015-05-27" version="1">MGRVIDRIDKYSKNLTREFIENDERFRKFTDILVEREEPPYLLYLDDGYLDITLNHICNLEYMSGTISRLAMVSFDEQMGIEFHRIHPNIPIATLDFSSVKNSIPERIPNRRYIIYQLALMLRSHIAAVLSSRGISFWSMQQDSIWTENFVSMEVEKHYPNSLLIFDTVGNDQFAVYERTMSGWICGATFFVRASPVTVEFFKKVALIMTRRQSPDSSIMTYLCGAPHYKCSKMPRWLVSSSNFFMGDRSVIPIIIQVDHSSNLTKMELFKRENLVFMKNDGTCNASAVIHVKESVAVALEDVRNNPPRNRKMSTFNYILWYFHRHLGFDPYYNKRFLRVHESLV</sequence>
</entry>
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    <accession>A0A0D8XXW8</accession>
    <name>A0A0D8XXW8_DICVI</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KJH47181.1"/>
        </source>
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    <sequence length="39" mass="4314" checksum="F5221F180C102485" modified="2015-05-27" version="1">MLETNCSDDGSVCALYALKPIVIITKNRHFGTLQELAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XXY9_DICVI</name>
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            <fullName evidence="2">Gar1 protein RNA binding region</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">DICVIV_06728</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="49"/>
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            <end position="232"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
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            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="24207" checksum="B0C758AA82F0D19E" modified="2015-05-27" version="1">MIHVSSTADNEFTSDMSFRGQGGGRRGHGGGFKGFRGGRGGGDRSFDQGPPQEVIEVGEFTHTCEDEIGFSVTLSEGVKAASFKVGQKLYIDPAKLMPIERFLPGYNQGGRGRGSRGRGSDRGRGSRGDRGGSRGGKGGFGQDRGGRGGRGGFGNDRGRGGFGSDRGRGGFGSDRGRGGFGSDRGRGGSGSDRGSRAGFGGNRSYGSDRGNHKRPSDNAATPNKRIKFEEED</sequence>
</entry>
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    <accession>A0A0D8XYH9</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716252">
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:chromatin remodeling"/>
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    <dbReference type="PANTHER" id="PTHR22880:SF225">
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            <end position="30"/>
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        <location>
            <begin position="50"/>
            <end position="79"/>
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            <dbReference type="ARBA" id="ARBA00023117"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="445" mass="49910" checksum="2586C4D9276DBEFE" modified="2015-05-27" version="1">MSGSTMNDDVANDIQMWHTSTELASETNQDVALEANTKTEASEEITKPAKNAKRRKSGTRRKRSTTRKLPRRSSTRLKQKQAEHVDYSQLPPKYEGPPSQSMRFCNFVLSDLMSSKYQPINWLIDLATVKRKLIYKQYANAEEFANEIRTTKNTIAKAQALVRELSLQEQYLGDMKYVRENARCQMKTPPKVIQSVWDSAYATFEKCGALPVYKNVKTEQNNEVCDKTEDYTVSEEPANIPPLDTKSDCGQDAVLANKESNLNQDGTDGSLSYIEQLQLAEDLKLLSDDEMSAIVDIILKHNTVKIPNDEKSVVSIFFRELKPATLREMATYIDSVLNSVPSPAKTAPKSRSGKSKNVVARKQSQPTKKRAVIVDIEARKRELMEGIKRLGGTGATKPIRKQTPYVDQYARVRNAYVHVATSVSSSSTSASESWQSSSSSETVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYS2</accession>
    <name>A0A0D8XYS2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XYS2"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25759" checksum="39AEEA5DB8973862" modified="2015-05-27" version="1">MRSVRFCTVTKSDDMRTREAPGATNGQHRWLFFCDRPYPNVEVGLQRDDFVLLGSLSSFRFHSGILLHPSVALLRILKDENASFSRPFFPRLNVNEVEKTFWMSLDRFLDDSLHTSFNIDKNYTVHSFMYYFIEIMKNILLSEKKKQKDICVDPKSLFEEAHTFGVTALLCIMTAMCVLQRMPSFDIMPMLTVSRLADMTPVDVMAEVRVNAERSYTSRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYX2</accession>
    <name>A0A0D8XYX2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716222">
        <property type="protein sequence ID" value="KJH49838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYX2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11786" checksum="AA3FA8B711BB19BC" modified="2015-05-27" version="1">MIVYSMNVNTIHLLRQCPSDLTVTLVQCDDICDATPCATELSGTSFHYRFHGAHYLKEEKRRHDDHLQAAFLSVRHHTISHKVYQYKYEARDSINGSTVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ95</accession>
    <name>A0A0D8XZ95_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ95"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13895" checksum="2EB770AE9C93B980" modified="2015-05-27" version="1">MERGIDDRVDSDIDESTAFSTCAIKASDEQASQHTYEPIEEDSVAEQSPVMNEMAPGRRITSFKSKDIDMETDNIPSTSKYYDEPVAEIKESERGQHQETFEEVELMDGEASVDEILSTFYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZM3</accession>
    <name>A0A0D8XZM3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZM3"/>
    <dbReference type="OrthoDB" id="6247020at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11077" checksum="9C4B0FA7EED31BC6" modified="2015-05-27" version="1">MRQSTIGSGLNTCGPYKGTRIPTCLNSNPLPEHPRIYERDHIHSKSWNVESTNGASSPLQRRGNYQYYQTITKRLVFTRALALKSPPTTPTNVRTCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0B7</accession>
    <name>A0A0D8Y0B7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="219" mass="24769" checksum="66FAF77F53C031F0" modified="2015-05-27" version="1">MLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLSCMTFVFCSLLELAWVGYLSREDESDDNITLTSEPALPAKTSPIPPLTSNKTTPVAPPTPRLQMHSASSTLHRRNQVNEEESALISLRDNDYGYIPPGFGLNGNIANTMRTLRGRCSCAPYTSYHDEFEETTPLEHPTASSHIPRRHQRERLAKRIDTLSAIFFPSLFSLFNIAYWSHYLRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y0I2_DICVI</name>
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        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="22014" checksum="F56D706D40EE3EB9" modified="2015-05-27" version="1">MFTLLIFIPTAQALFFGSSGCGCSPPPVCPPAPVCGCASSGCASPSYASASYPQPQYPSQYPQQFPPQYPPVQLPPSVYDVGPPRAGEYTGPSQKVVNVAEKTAELSSNGVDSYLSQTPGSRVRRDIEAAFDPKCNSEILKEIILKNIDKSTAVSKRKIQEAATADIGGRIDVICSTSTFSYIVNTELYCETESNGITCFAFRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0L2</accession>
    <name>A0A0D8Y0L2_DICVI</name>
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            <fullName evidence="7">Serine/threonine-protein kinase PLK</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="7"/>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
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        </source>
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    <sequence length="605" mass="68405" checksum="32699A468F006215" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="357" mass="41097" checksum="2324FEA98C5FC4B1" modified="2015-05-27" version="1">MELYAAVDFAYPYKFPEWICKIRAYLIEFTSYASILKIASLKDQRSMARNQSPFKDQSSKINVKKLVEHYLKPYPIRSQSSPKISRAYMTIIIMWIISSIAAIPIGFIVKINRLPLPEWAIEQEWTHKVSDDLDTIKNTDFCAMDVEKPNLQSHIISFAFIAFFMIPAILITLMYTHIACRIVFTDSLLYGVENNKVRAKATNTVIKMLVSVVISFFLCWLPFHIQRLLSVFISYHDGDVSPAIETVFQLVFYISGCFYYSNSAINPILYNVFSEKYRRAFCTTILGRKIAKRIRPQWYMAKSGALLCTPQASCRRSNVEYSINASRHTGTSTKLLRHPKESYNKSNSDFKTAAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y234</accession>
    <name>A0A0D8Y234_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glutamate:sodium symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7977" checksum="BAA8D320022ABA18" modified="2015-05-27" version="1">MTLNHPSTNVRMSPILTTMLRFCRDNILLVMTIISVILGVSLGFGLRPLNLSAETLQLINFPGEIFMQIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y271</accession>
    <name>A0A0D8Y271_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03035</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716197">
        <property type="protein sequence ID" value="KJH50790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y271"/>
    <dbReference type="OrthoDB" id="5783007at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="189" mass="20974" checksum="EE3AB647E1132B3D" modified="2015-05-27" version="1">MFIASRITSALGNGEGDDADADASRPKTYRSESGADYFSANHFRHQLVLNSNVSPMDVVTSTNGVDSGRLSVNQEWMSLNCQLACGTCKSPLTAIDVYTDSFPADDYDHIVLPEAPDWLVSARNAKIDRRWKKKKYCWLIISARNSLIMVNATGQFILGTQEANEFEIVEKYTKGQGCAIFEEIAISLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2H3</accession>
    <name>A0A0D8Y2H3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y2H3"/>
    <dbReference type="OrthoDB" id="5852397at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="19856" checksum="6EEEA330D1AD06DF" modified="2015-05-27" version="1" fragment="single">DPSKCAYKYGDGNCDAECAGAECGFDGGDCNDGHSVSHSHDVNMIGIALEMPPEIAVKNLRHLQAVLAQRLYTHVNLAKDVYGVMIYEWSSDRGQGDRVDIVNEQFVEKVQATAPGSLIFFDVDTTGCRLITRKNYSGAHCFTDLRAAATYLTVELTRSQPVSGETLPIRDVTWKRRQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y382</accession>
    <name>A0A0D8Y382_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y382"/>
    <dbReference type="STRING" id="29172.A0A0D8Y382"/>
    <dbReference type="OrthoDB" id="5857858at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="723" mass="80144" checksum="A66CA14D68ACECB7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3P6</accession>
    <name>A0A0D8Y3P6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_03169</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3P6"/>
    <dbReference type="OrthoDB" id="5873841at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="22020" checksum="C7B812BE8304980F" modified="2015-05-27" version="1">MVTRLTYFNGLFLFTLNSKCSTIQGKTRNMRHPTGNDSVSNKYSVYIFIMSMLLPTVLFFLLVLLYICCKRHPEKVVRRSRRTRAREIESVELHQEFFKDKGVLVMQSSFAGPVKHALQDVKSVSIKRVTYDDAQNSIIGIGTDIEKLEGRSYSTQMTQLSDDVQTCRDVSPTFMKNLEKNTMDSRISERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y431</accession>
    <name>A0A0D8Y431_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aurora kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_03090</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y431"/>
    <dbReference type="STRING" id="29172.A0A0D8Y431"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="48"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="36412" checksum="CF1BA6F9057B54F8" modified="2015-05-27" version="1">MPEVETANANQVQSQSDNSKNSGKCTANSAVVKPDSRNVSRTWVIDDFDIGRPLGKGKFGSVFVARSKEEKIVVALKVLFKDQIEKHNVKHQVKREIEIQYHLMHPNILRCKGYFHDQQRVYIILEFADGGELYNRLKKKGRLEEPEAAKYVRQLADALSYCHAKKVIHRDIKPENILLDRKGNVKIADFGWAVVSSHSRRETICGTLDYLPPEMICGGTHDHTVDNWAIGILLHEMLVGRPPFEFPDQNQTLAAIKTCRFIIPKFVSDGPSDLIRRLVVKEPCMRLPLSGVLAHPWVVSMSNLASSEMNRHTVPRQNSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4I2</accession>
    <name>A0A0D8Y4I2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="2">
        <location>
            <begin position="71"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="337" mass="38400" checksum="124DC2FD0B92943C" modified="2015-05-27" version="1" fragment="single">VECIASWHSLGHIFFAARIGNERGESYRCFIVDRMGTSGRIGISADASCQELTDISSATMTLQYKQDHEIHPQCNFPDYLQANFGGILQSWESIADGKRNVIQNGYWISSYKARNDSIWMCLESQLIDNVVAIRAHIRRGCQTGYQCLQFHRRAPHMVQLSFGKVTFNEYEDCSEMAVESRDILVLQGTQEDCPLRGQYFSSNCPHPLLFIGCQKSNEIQIFSECQKTSHTDVYKCIAHFQHVNEHYMVVRDQISMQLQCLKFLISDEIIVEIFDHISCDSFSTTVALPSSMMNISNKARCESSFLAGFLQYSENSISHKIYYTSLTATFLMILSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5H9</accession>
    <name>A0A0D8Y5H9_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01801</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="77" mass="8653" checksum="41C911E4F668A726" modified="2015-05-27" version="1">MLDVPERLSIHLEYVYVFSFSVIPWSLIIPGFSGFEFNGVREMMGLVSLEAIANLSATLLGLHITRASPLHQTFPFK</sequence>
</entry>
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    <accession>A0A0D8Y7K7</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716161">
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="74" mass="8728" checksum="026352DB5871292B" modified="2015-05-27" version="1">MPQEFSYHPWQAIMVSLCGISIRRRYNQFQGTLMWTLEECASFCEVLNSFHLVKTRTVKSSVIHSDYRKPIMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7V0</accession>
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    <protein>
        <submittedName>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43740" checksum="942E35F8633A802E" modified="2015-05-27" version="1">MHRNYYVIEFVSFLLDISIESRAANSHVFISVKQKMDVNKDVMAEIQKLLSIILSLKSLRCCSRLARTWQSFTDVSAKNMDGTEWKAALRLQIEALAKRNELHRRCNRESVYARTADMDVKIVRLRELVATNANYAAQFYLECVCHADETERILNRQVSLPLQPALFFCFYSLESVAVGGNYARAESHSVTVIFVSHMTYNLLNANVLNGASAIETFPECSVINGELLWWKKFSIHCKGKEYHEVRQLWATQVDFFLSCLGFIVGVGNLLRFPGKICEHGGFFLVPYFFCSIFIGYPMLYLHLCVGQYAGQTIDAAFQRLMPITCGVGWAFVLAAIPVIIYHNIIITWSVQYLCYAVFSSMISNQLPWESRVVFFFASYLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9A7</accession>
    <name>A0A0D8Y9A7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9A7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9A7"/>
    <dbReference type="OrthoDB" id="10065073at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="24584" checksum="471B8B957B43073C" modified="2015-05-27" version="1">MRQAGMPPKSVKLNGGAASHVASADDFSYADLDLIFPMEVENSDSFDKVSGEDDRWSLFSLHNDFGRCIELKFVDKMRRQFEFSVDSFQITLDSLLDDFNAPEPKVYIESMFGDVHQAMAHLHERLIDTRRPEEIRGGGLLKYCHLLTRGYKAARPSKCRQLERYMCSRFFIDFPDVVSQEQKLRNYLDNHFGLNNDQVRAHIRLVIMYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9T8</accession>
    <name>A0A0D8Y9T8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear anchorage protein 1 spectrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9T8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9T8"/>
    <dbReference type="OrthoDB" id="5851525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057133">
        <property type="entry name" value="Spectrin_Anc-1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24615">
        <property type="entry name" value="Spectrin_Anc-1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear anchorage protein 1 spectrin repeat" evidence="2">
        <location>
            <begin position="422"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="602" mass="68467" checksum="1D92D2D29B9115A2" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB15</accession>
    <name>A0A0D8YB15_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB15"/>
    <dbReference type="STRING" id="29172.A0A0D8YB15"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="33753" checksum="762C4F55F473A788" modified="2015-05-27" version="1">MALFVGSLRCFARSNGGLILDQYRAIIWPILAQRLLTSEEESDDVDYDADSFDSYSHSSVVSSLSENTIDPEEEDILRSHPEWHQVELDVHRTLARFPPNISDDRRSTLQCQLTPLIIRVLRTNPRFRYYQGFHDVCLTVLLVCGAKTAFDVCRSLAHRGPFRAYLLKSLEDSVLKELEFLYVILSRVDPYLEKILREIHLGTIEMPVIHQLLSTMPHELHLDAILSDSLYLASLMPPLALKSKFLQIYKQQIKTPNINREWTYLSRYAITMVAAVGIAGAAYYFNIGGRISFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBF7</accession>
    <name>A0A0D8YBF7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_01965</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBF7"/>
    <dbReference type="STRING" id="29172.A0A0D8YBF7"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000315">
        <property type="entry name" value="membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF183">
        <property type="entry name" value="MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="107"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="463"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJH51886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="792" mass="90533" checksum="469FE510ED612F2B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFH0</accession>
    <name>A0A0D8YFH0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ryanodine receptor junctional solenoid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFH0"/>
    <dbReference type="STRING" id="29172.A0A0D8YFH0"/>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ryanodine receptor junctional solenoid" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor junctional solenoid" evidence="1">
        <location>
            <begin position="163"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39972" checksum="7C43F13DAA8BFD09" modified="2015-05-27" version="1">MKLLPPALNFDALKAHVMNAMESATRHAVMNCRDLIGGDNRNHFEPLLKLFDSLLVIGLFDDSELEVILSLIHPASFDSNSKILIWKLNKLIWRQLKPLKKTKEFRCPPKEQMFRLLKCKATSFSISDEKYKQGEKELYDKLNFDKYKCTGKVKEEKEDFLDDEVEYDQCPMAESLQEQLRDFCSLLVAKIGNVDEYNDEQRQDLIRAEEGSWVDSLARLVVAVPPPPPTSDKELIARNGTRKFREVIVTMLREWALGHFIESSELIRKMFNLLLRQYSGVRELQDAMSQTYVLHERNNDDVKDFIIYLIQIRELLTVQFEHTEEAILKRGLWSDLLFCFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YGD1</accession>
    <name>A0A0D8YGD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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    <sequence length="90" mass="10201" checksum="1C9A4D17A8DE9479" modified="2015-05-27" version="1">MLFRMTIRQSSKEAKETLFANVRLNDLSQHKRKVVYGSNKLSNSNADLLSSSSERLLEKGTAENFVYHEETMEIDVAPSIDLLVSTQLQP</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="101" mass="11454" checksum="DE022A6DE622F74D" modified="2015-05-27" version="1">MSGKYGVGIRDIYAALRNNLVPHRWDEDLLPFLQMVQAETAQLGCSIQLCKPRDKASFYSVVCRYSIPHVKTRVPLYLTGKPCSQCRKGFKCDQITKLCVS</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7149" checksum="FD8B32936C386C30" modified="2015-05-27" version="1">MYQALNAGTVPASVDDRILLEKRKQIIFISTELSSVFPSASSFQLQLSRDYLVDTLQRMITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">DICVIV_12904</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18128" checksum="2160148D58A4436E" modified="2015-05-27" version="1">MVLLILFFFVLAKDVVTLSHSNTKEIEINRFTKSYAKCEFSVHKDGPDGVLVTGAALDMELYYSIKCEPYDDHCLFVSNCTISSDEAGLKPYPVIDEYGCSLEPSLYEHVTYVSNFIAGIRNPYPVRFRSSSGAVVLYCVTTLLPTTAEGTCNRHECMSTPSP</sequence>
</entry>
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    <accession>A0A0D8XBZ7</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716705">
        <property type="protein sequence ID" value="KJH42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046982">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="327"/>
            <end position="414"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="419" mass="48151" checksum="02AAC2AD160FCEA0" modified="2015-05-27" version="1">MSSSGSPALTTMLLPSPVQVRGLLFGLINSETILIGHTLENDLKALRIVHDVIVDTSVLYSHSGVGGRYFKRSLKSLAREELVKCEYYFSYPPFPSFSTLLQFMSGLKEDFISCLLQFMSGLKEDFISCYLVVESVCDFRHSGVGGRYFKRSLKSLAREELGIEIQTGNGGHDSGEDAWAAMQLELLRNFTLLLADDNQYTVQYPSSPLTNRSNVQYQHYVNENRNPNLYNKTSQNEYMTSQQDYSEVLESQIGNANTHWNYRISVQKRQVNEYMTEPECPGRLKSPQDSTTITDSTSRIWNENVPRHRYDPHSRVSKVKGKYRYRPGTRTLKEIRHYQKSTNLLIPKLPFQRVIREVAMDLFPNHELRFALDALEALRVASEAFLIHLFDASCTCVLHARRVTVKPVDFHLVRLLQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC21</accession>
    <name>A0A0D8XC21_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716855">
        <property type="protein sequence ID" value="KJH41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC21"/>
    <dbReference type="OrthoDB" id="5794962at2759"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20426" checksum="75D50BD6664545AB" modified="2015-05-27" version="1">MIFYLVIDIIVLLLQITDIISNGFILFAFVRKRTLRQGSSIRLLLYLTLSNVLHALTTLPYSIYLTVSWNSVQIILNPYYTLISGIPNILQMKIDLTLTICLAIERILIMGIIVIILTISILIRLQIIQKRTQLNRDVYHYDKNKFKKSSDTKMYAEEEKRSHGDKNPEALTSHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC88</accession>
    <name>A0A0D8XC88_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase family M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">HannoverDv2000</strain>
        </source>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30982" checksum="7AEB523ABE643EAE" modified="2015-05-27" version="1">MWGSTESISGNEDTEVASNQWLIGHGPLNQEKVYSLTGLNNMPDGEFAVAQMKTFGTTMLLSEVIRCAMAKVSIQFDLWLTGTAKLQVCLVDNSTPLLLDCQAASPGTVIVDLPRIERPFRIALRAESANKGMVIIDNIKVQGELCPSVLRHYSSKSYHPVANQPDPNACRLLSCNFTHGHACLYESSQIQNGSPHEITHDAIVSQLNSLQSISILESPTFRLNTISRLHFSYTIEGDAVLFVCNDSANKELESCFKVEGRQGEDYIEMLPSDTKKRLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCD0</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
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    <sequence length="274" mass="30938" checksum="FDFCD07ABA1E5D8D" modified="2015-05-27" version="1">MSVIARQMASSPTSLAFLQYSGLFSLLLLKKGTILASLITTVTTIQNSRNIKEKYLLDLYEFLWNCIKSFLIIFVSSFKIYPAMMIRILDGIWVGLRNLYDLRSVYSKDNIMYSVTSMIHDEAEFVAYTVGSDQLLCFNLQHYANKMLWISLLSYLSHVTNGEQAILEGPQETFVLLGQTAVLKCKVDNQKGAVQWMKNGFGLGVDRQLKFFPRYSMIGSASKGEYNLQITNVTIDDDDVYACQISEVAYESSVISNPAKLTVLSSFQLIEKIV</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716678">
        <property type="protein sequence ID" value="KJH42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCJ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XCJ4"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="18979" checksum="6C020218D335C3E5" modified="2015-05-27" version="1">MYYSIDSPSFPMYLKCGCFELLVIAAFLFVLVILISKSTLELFGLDTLSIASHAPAKTLGGKLHCDPDMLKPSATIPDDVDKVRPADIKAIAAIGDSFIMAARSTNFLDDPLDIFPGNSFISGGDGTVEEHITVAKILRIFNPTMMEVSYGAGYGNMGSNVATGRATCKDVFVQAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCT9</accession>
    <name>A0A0D8XCT9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716792">
        <property type="protein sequence ID" value="KJH41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCT9"/>
    <dbReference type="OrthoDB" id="5819201at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35671" checksum="E6B3FB4B0A851FF0" modified="2015-05-27" version="1">MTHIIKLITNVNPCDIDFDVTFCFICRFITTTCTYSHTTVLFGLLLERVIATKFAATYEKTSIIIGFGIVVTAISVAILLSYAKIHKFFLNKSMIYCSSLTFSTHLDNIAVHATLLSMLLVTIVVFAIIFIQNRNLRKRITRSINEKYQASENLRILRLMGPVLMLHFIAYPTYFAVTLIMQIVKNFIESEKFRLIYSACYDHTKYQRKISGIRKLTNITIDGSRVDVTFYSLSNIFCCYVNYANREKFHRKREISLNIFSLLLSILWYSIIQTKKHEEKDNAVFHRTAPQQENNIYFQNYTAMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD83</accession>
    <name>A0A0D8XD83_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_11426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716649">
        <property type="protein sequence ID" value="KJH42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD83"/>
    <dbReference type="STRING" id="29172.A0A0D8XD83"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="132"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="330"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="652"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125907" checksum="280A10B9186F0339" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD91</accession>
    <name>A0A0D8XD91_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_11400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716647">
        <property type="protein sequence ID" value="KJH42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XD91"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="50000" checksum="6170F216B9B3494C" modified="2015-05-27" version="1">MPTYLPEYITVSSLIDKVPGHKPTNVRLAMFIEGMSSFRTQTMDFQLDVYFQQFWKDRRLAHNESRRILIRDKRTLAKIWHPDIYFANARIAEFHEVTQPNFLLWIEPNGSILYDTRISMVVVCTLNLEKWPLDTQRCHLRILSYAYTTDQLQIEWIKGTPITRNPNIAMSDMQIVDLFPGLCDGNYSTGTWSCVTAEFFVKREVTHHVMQSYVPTTLIVVISWFSFWLDVEAVPARVSLAITTLLTLSTQANAARMALPEVSYMKAIDVWMGACMMFVFGVMIEFTIVNYAQRKATAESASTKSQREGVAKGAQIILDYFGINRQTTLEEEDLLDHLVSNGNLYDPPYVRSSRKPLLYCNNCHKVDLEMQWRQSNDKTVTVKANTINRIGKKEAARRRAKQIDQKSRWVFPLSFLAFNALYWSYYLYFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDG6</accession>
    <name>A0A0D8XDG6_DICVI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717177">
        <property type="protein sequence ID" value="KJH40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDG6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6814" checksum="3B1A3EBF7F921ABC" modified="2015-05-27" version="1">MNYLWNSATIYVRVSDKIWSHRRHCKSPRVADLRSAKGLCSLSKHSGIHWFNLLYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDH9</accession>
    <name>A0A0D8XDH9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF8077 domain-containing protein</fullName>
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        <name evidence="4" type="ORF">DICVIV_11337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716640">
        <property type="protein sequence ID" value="KJH42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDH9"/>
    <dbReference type="OrthoDB" id="5858611at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058390">
        <property type="entry name" value="DUF8077"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8077" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="343" mass="38460" checksum="BE7ED872A7FBAB14" modified="2015-05-27" version="1">MFEWSSGIRVAYCVDVPLPDLLLPFRRTFSKIVTKYCHNITACNLKKQLVFGPEHIMFVDGFPRREYGAIHIKFYVVFPHNTEAVTKQTRPLLPRAVLSDIISKHLTEISNRLGWSIISYEKYPRFDSMTEFMNIAIIPIVIFSVPLMIFLAYWTSSLRPNMSSEAWLVTGATGGKNAALRRTMEIIAEQNAEIDRQNRIELTKHMIITGGNEGLASSGQLLFNVAKMSMGSNQQLNSYVAAPHSSPSHMTAPKITVVMSNYDEHGASKSSLSSPRGSVSTLLASASHQLSVARGFGPRKHNHRQLSTEELKQMRKARYSQSHSKSKPWKAGSLMLGGFTRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEF3</accession>
    <name>A0A0D8XEF3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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        <source>
            <dbReference type="EMBL" id="KJH42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="34742" checksum="BCAAE711A7E71038" modified="2015-05-27" version="1">MPTATVDVKPLSTTEITKEIVNVKPVVPSNLSKDDVRSKSNDVDDRDADLAVGQYPCTADDHFEVRLIDAVEKNPCIFNRCHPLHKMSDYKSHVWNQVAQQLSFSGPGVELERKWRHMRDRYVRLRKIDKTSTPLKKGDKWYYYYKKMSFLDPYIEHRNRRKRGDLVASLMKLGGNGEALFDSQITERNDEEEGSDSGEGEIEDRCDPLKDFYASFAEQSMAMPLPLDVEHCEKLSQPLSTSSKRRKTDETHEDCIADTEVSLFVRSIEKSLSGMDARTFALARLEISRVLYDCQYGDRKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFB5</accession>
    <name>A0A0D8XFB5_DICVI</name>
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        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716664">
        <property type="protein sequence ID" value="KJH42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFB5"/>
    <dbReference type="OrthoDB" id="5810156at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="9531" checksum="A0730E423107DEB3" modified="2015-05-27" version="1">MNYILYIMYYFINTNNFILYRLLMFMNIEYVADAPFTLNGENISERSSYEYLGRECIKIIDLISSEEFCLKFPQKTEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFS6</accession>
    <name>A0A0D8XFS6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DBP10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716880">
        <property type="protein sequence ID" value="KJH41206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFS6"/>
    <dbReference type="STRING" id="29172.A0A0D8XFS6"/>
    <dbReference type="OrthoDB" id="5875111at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBP10 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13749" checksum="F5A34EE8A9FF5DFC" modified="2015-05-27" version="1">MKRIRTEDGTWLPASYKTGRYEDWKKKQKIVYKKNDESEPVHLESAGCARINNKGKKFKTNTMKKYPKGRKAELRNVDQIKKIRKKSVMLRNYMEYRRLQNLKKKAARIGNTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFU2</accession>
    <name>A0A0D8XFU2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716877">
        <property type="protein sequence ID" value="KJH41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFU2"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="161" mass="18879" checksum="BEA27B2100AD3CAC" modified="2015-05-27" version="1">MMLLLWIFRMILPYSIIGILLALIANAYEEFPYMNQMSSPVQPYPGLTPPVQTIAVYVPPEYNNGPYGGVYPGYDGGVFNDMFYGPSYKPHSPPLYSPYSPQYENPRLGYPYGLYSSFANQFLGSRYRRRRYHRRRRERDSTDSRDSRDRNDSRDSRDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFV0</accession>
    <name>A0A0D8XFV0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716648">
        <property type="protein sequence ID" value="KJH42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XFV0"/>
    <dbReference type="OrthoDB" id="5839404at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF5">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15727" checksum="5A2FA863AAB39942" modified="2015-05-27" version="1">MNESSKSSAGLVVCPYNLNHQVEPNLFPDHLRTCRLRYCRQSVQTLKLVRCRVNSRHFLPEIEIEFHEKLCEDQIHLQIMTELETEPIPVKIPSSDSSENDEDSDNETTTSVSSGDTDYSTSKDELLRRILDDCDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG25</accession>
    <name>A0A0D8XG25_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sel1 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
    <sequence length="284" mass="31109" checksum="427A6DD70F67EEF7" modified="2015-05-27" version="1">MSSQRLALSHIIRHGQRFVSFPHPASSNDKRESPASNIPRFSDIVLPLLGSNYNGLSSIQFTPLLGSYHWTPSLVFSENGSGSTYTIKVGVQTDDCEIYPVTKVDPIIRKEKAKWDLENLIGEELLKAGKTSSAITRFQAAASHGNANAMNNLAECFFSGLGITCNKEMAFSLWEQSASLGNANAMYALAVCLIRAATAGEPKGDKTRAIQLMKKAALKGNVHAAFYLVVRHIRDSDLEEAESVIRIAACDEGYASEMESWTEGNFLDVMCSQFIKQALMDSNF</sequence>
</entry>
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        <lineage>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716623">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="14806" checksum="70D19346E4A00E47" modified="2015-05-27" version="1">MEMFSENILINNMRSSTLVVLLLVIVQFFFPDCHDFGCPKKRNQVRSCQQLQYHELNRGSGEASGEGSGEVDSSGESSGEGSGAEASGENNKDVSVTDEPKLLMIIKLLENNIDRHETKKKKSQLKTEKNEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
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    </comment>
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        <text evidence="6">Belongs to the group II decarboxylase family.</text>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHZ3</accession>
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        <submittedName>
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    </protein>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
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    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="387" mass="43267" checksum="DA303F5C3D902FC8" modified="2015-05-27" version="1">MKQFVFLSSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNSVFAPILNCSGGTFLPATTSNKKIFFERLGEIDERDQAHVSPPLKFSLSILRENVNSSTSLFRNYRSGGHKLLMLFTDGLDEWPHAVMDEELRNQNGDVIRMFGFSMGYGTGQLPLLHWMACNTFAKYSVIDSIMDVKPQSRSFLDHLSVALGRSLENTPIEARRISWTSLYMEAQGLGPTITISLPIVTKPNNIWLGQRIAGIAGIDIGLCELTEKLPKEEQLYGIIVDINGVIIYHQSLNLPATEVHAVRRSACYDSSHIRHRAGSGLRVQYGFSDERVYRLVGLIDSIPTIDLFELEGNSSAMIRLRHDIVTRTCDQKAIVDEAISYGISLCPYPSTSTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIC8</accession>
    <name>A0A0D8XIC8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDK5 regulatory subunit-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716550">
        <property type="protein sequence ID" value="KJH43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIC8"/>
    <dbReference type="STRING" id="29172.A0A0D8XIC8"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="59432" checksum="9DC9DE45638FF753" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIR6</accession>
    <name>A0A0D8XIR6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716698">
        <property type="protein sequence ID" value="KJH42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XIR6"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26062" checksum="6C90C871AD12A2AB" modified="2015-05-27" version="1">MSRESIVTLIHYENMKKSSVILLYFTMFFMLNIGGTVVVIDDWNFGIQGMSELQALLLCSGSGSRMTLICNSVIKCLLPVADVPMFWYPLKTLVSSGVKDIKLFVREDGEPEVSRLLMTPLFSFPSANIEVICVSRENEDWGTADLLRHYASKISRDFIVMSCDFISDCQLQPMVDQFRAHKAAFSCLLSDMCIKGPVPGPKRHIVPREHPSELEMFKGDRHFLLGGIDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ31</accession>
    <name>A0A0D8XJ31_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA ATPase AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716529">
        <property type="protein sequence ID" value="KJH43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ31"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ31"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9442" checksum="62B87F4A8774A38F" modified="2015-05-27" version="1">MRTKRMILDDDDIVDRLVEKTQGYSGAEIVAVCRHAALLAMREDITTSTVKWSHFNETLTTIVPRTDQNMLRIYEKFKLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJS4</accession>
    <name>A0A0D8XJS4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="138" mass="15633" checksum="555DA8C8C10F9E9B" modified="2015-05-27" version="1">MDPFELNSIKAMVLFNPDTPSLQETLKIETLQEKVQTSLDEYCRSQKPHQLGRFGRILLRLPSLRTVNASTIETSLSKVYHINDSLSIPMAGSSNSDIFICKYSDHQMTLCLPGQGFERIQKSCSVALFENTKTDKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716493">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5829006at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DB"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17622" checksum="4CD59047E03F2DF5" modified="2015-05-27" version="1">MPQRYRHNVSRGEVKCGIAERNYQPCTSTLIANRLFKSCCDLYVPEECHFMCKYEIDHNKTRKMLIDLVKSKRCNIRYLPSILYCASQNRDNRKCCADLDLNASQLQVGSRCLKMCDPSGTAIEKIIRQDVTCLYNWNVIMYCHHAGIREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK44</accession>
    <name>A0A0D8XK44_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716437">
        <property type="protein sequence ID" value="KJH44968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XK44"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
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    </dbReference>
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        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
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        <property type="entry name" value="OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00907">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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            <end position="130"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="130" mass="15192" checksum="9B6A8072AF2C9BA0" modified="2015-05-27" version="1">MLVEKRQTLAIRKLATELPYTMPKNFSIDYLLSDFENAQRNEGVVKRGSIRFRLEGISLWRRFHALGTEMIVTKSGRRMFPVLSISITGLETNVHYSLLVDMECVDSQRYRYSFHQSKWTATGPEQIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK94</accession>
    <name>A0A0D8XK94_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UAA transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716431">
        <property type="protein sequence ID" value="KJH45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XK94"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="338" mass="38511" checksum="BB5A36EB97717316" modified="2015-05-27" version="1">MIVRTIVHTLAGCVGCQAGVELLNRQVKNSLNLLTLTTCIFVSLEGLFYYWKSNTVKQSIPTRYEICFRSFRVCLLYYYVIFMKLFSVYIKIVVLFFFVNLCNNYAIRCDVYFPLFIIFKSGSLLANIVFGYMLRGHYYTSREVFSVIIVTGGIIIFTLASYEKRTSMTTEPLNNAFILSIPPFFVGVSLLSIALVLSAYLGVCQEDMYRIYGKHVKESMFMVHFLSIPGFALIGNDIIEAFQAANKTPSLHMFGYDLVLPTAWCCIFGICILQYICINNVYRLTSLTSSLNVTMVISLRKFLSLLISFVVFDNTFNIFHFCGAVFVFIGSLMFSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKF0</accession>
    <name>A0A0D8XKF0_DICVI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_11217</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716625">
        <property type="protein sequence ID" value="KJH42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKF0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16418" checksum="A15C19490BDD89BF" modified="2015-05-27" version="1">MLVLERPRLDAPRPRAKWQSMGAVSFVHCRLPWWHLITLYIALHSRWKPCVYDTYRTRNVSTECSERLLVLLFCTSTLSSLCFMLWAPSGVTLSSDPVAWLAANHRLHRFARGRVSNGDAETIRRGARHMVPFLLLAAGMVNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKS9</accession>
    <name>A0A0D8XKS9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716475">
        <property type="protein sequence ID" value="KJH44419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKS9"/>
    <dbReference type="STRING" id="29172.A0A0D8XKS9"/>
    <dbReference type="OrthoDB" id="5856808at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF39">
        <property type="entry name" value="PROTEIN HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="21816" checksum="70AE271C257CB92B" modified="2015-05-27" version="1">MKSLNFTFLSLEPSCLRSGRAFAEVLHGIDEQFFSDVWMEKIAQYESNSNWRVKANNLRKLTRSLGEYYEEHVHRIIKGTNLLDIDEMEFAEAGSPKELLKMAVLIVGAAFLGRTQKQFVDGIACLDANVQRAVMTAINYVMGISKKSEIPTSLVEGSADTVDYFLTLKAIAGLMEVMAKKTDAKLICYLKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKU0</accession>
    <name>A0A0D8XKU0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716606">
        <property type="protein sequence ID" value="KJH42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKU0"/>
    <dbReference type="OrthoDB" id="5845413at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056868">
        <property type="entry name" value="Lipocalin_dom_nem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF5">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24976">
        <property type="entry name" value="Lipocalin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin" evidence="1">
        <location>
            <begin position="58"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="244" mass="27496" checksum="0B313A7C73339B0D" modified="2015-05-27" version="1">MFSRLREPLPGMNFMESIPVLPGVMGNLPGAGSCLPRGSPLVRDKSPSFFQNILRNIPGAHDYLASLLPSPKIDIDALLGKFHWAIDTPSVHDRFCATIDFQRTAKAGNSASFSLQEKFRTQSENGGEKIAFGYGILHKDRTYVYMQDDPCPYQIVIVGPRKDGNGQYEYVILSNWARFPLIGLVRDIRVFYNKFKDQLETELEKEGFINEYSGSSSIHYSDWSKCRPATPVSYIQNVLTELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLV9</accession>
    <name>A0A0D8XLV9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="114" mass="12901" checksum="3CE23147FEA70660" modified="2015-05-27" version="1" fragment="single">MTLKTFGGIDILVNNASAISLTNTQDTDMKRYDLMHSINTRGTYLMSKLCLPYLKQGNNPHILNISPPLLMEARWFSNHVAYTMAKYGMSMCVLGMHEEFRPYGIAVNALWPVT</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
    <dbReference type="EMBL" id="KN716438">
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="210" mass="23382" checksum="0501613DF8953321" modified="2015-05-27" version="1">MLLEKRSSLKAKLLSFDDSFLQSPRNLQSAAALPLPTTSEDNECERDARGTSNDLSLLSQSFISKMDHWQLLHPPLQDFVTPSAPPLPTDPPIWTSDAWTGDLYHPPYYTPVTYHASFQSLPRPSYYDLSMADCQQWTTPGAGHTSMDNAVTLTNIEDSNQLFVKDFAHNYPFTVDYKVPIDYAMPTVLASPGNGFQLISEVTNTLLGHG</sequence>
</entry>
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    <accession>A0A0D8XN11</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716422">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN11"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="120" mass="12745" checksum="9EF61D63481D3B7D" modified="2015-05-27" version="1">MLRLPRRPSVLRAVTLAFRDATSQPQCVAAGTSDVAIGSNVSDSIAENQLAEQMSIKFFSGLQDLLGLYDSSIASSTQTASSVPSSSSLFSSALGSSTVHHRRKSVGECKQKFINSGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN79</accession>
    <name>A0A0D8XN79_DICVI</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716368">
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46113.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        </source>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_MER3"/>
    </dbReference>
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        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="225"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="835" mass="95930" checksum="B2608E0E7F0B21DF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPZ8</accession>
    <name>A0A0D8XPZ8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716343">
        <property type="protein sequence ID" value="KJH46625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPZ8"/>
    <dbReference type="STRING" id="29172.A0A0D8XPZ8"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13308" checksum="A61E522181A124A9" modified="2015-05-27" version="1">MAGIAYKNEKPLPDNTEHRIRLTLTSQDVKSLEKVCAQLIEGAKNENLVVKGPIRLPTKILRITTRKTPCGEGSKTWDRFQMRIHKRLINLHTPADLLRKITSISIEPGVNVEVTQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQJ8</accession>
    <name>A0A0D8XQJ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ulp1 protease family, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716458">
        <property type="protein sequence ID" value="KJH44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQJ8"/>
    <dbReference type="STRING" id="29172.A0A0D8XQJ8"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="28091" checksum="4C137A1DFDA4495C" modified="2015-05-27" version="1">MNVSQKVVPFCRLSNVMRTLAIMTIYSMNLRVDQIPKFGEKNTLVTILPSVFWHNLSILHSGASVALDARFGDILDFVKDFDFIDVDYIVVPVNEWEHWSLVIICHPFTASARMVCFDSQQSEDLNNMQNIAILCDGFLKYVWMRRRKYPLCSSEPMCCITPGCLPQQSNNFDCGLYIVEFARRFLLAPPYNLDEFNFSVEYPDFSIEGKRRDIQNTILSLCSNRELWVPILEFLNRDSEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQY0</accession>
    <name>A0A0D8XQY0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PHD-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_07010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQY0"/>
    <dbReference type="STRING" id="29172.A0A0D8XQY0"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="DPF1-3_N"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
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            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <end position="193"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="432" mass="47744" checksum="69E8401F722D88A1" modified="2015-05-27" version="1">MINESAYIELMKNCSKWNERACNERRARLRYPFFDQQTGTAHRFNPVFYRSPCQRSTSTDANTFVQYSTCRWRRRQSANSSDAIEMKMFLRDNPALDAALSTSTAPAQSDSVDLVYDYGQGKGTPKGLFDYNEEGDDDASNDDGGSDEDDWGSKRKSRKSQGGVSGSGSGSKNRKKASEKASRSSTASASARQDAADEVNNFQCTSECGGSVSAGNPLRVRRVPPSLGVPRPAGFMVAGCAGWLLQLLLFIIFLFYLFYLKRHLCSVCPASYKSLAGLAYHKAFHHNDPLSSDSSIEISPLLEISPICDLCLGSKHMNKKTKKAEDLVVCHDCGRSAHSSCLNFNENVPIIIKRYGWQCIECKSCTICGTSENDDKLLFCDDCDRGYHTYCFTPKMKSLPENEYSCSLCIKTFGANASAVVRCNTPPNSMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR60</accession>
    <name>A0A0D8XR60_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH47000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XR60"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR43157">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF68">
        <property type="entry name" value="RETINOL DEHYDROGENASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336119" evidence="3">
        <location>
            <begin position="18"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="4">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="579" mass="66569" checksum="8659CCD48F33BBEF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRE7</accession>
    <name>A0A0D8XRE7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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            <end position="546"/>
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        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46324.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="123" mass="14348" checksum="7D1D45966D57ADBB" modified="2015-05-27" version="1">MVGDTVADLKMGRLAGLRATVGVLTGVGNVISLKEYSDYFVNILVLFFTQTNICWTTLATFLCLFLRRLTRIQKEVESLQSESRRSSLHCFPCCLRRYRLYHCHYLNHFIIAVLLLTYWHRLN</sequence>
</entry>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTD9"/>
    <dbReference type="STRING" id="29172.A0A0D8XTD9"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06615">
        <property type="entry name" value="PKc_MEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000115">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="75"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH45646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="391" mass="43712" checksum="A95AE7AB467C6344" modified="2015-05-27" version="1">MSSGKRRNPLGLSLPPTVNENEKEDGTKEEETVVQMSLDEQLRRLGLTEPQKQRMCEWIQVKEAIKEQELSEDMLENEGELGHGNGGVVHKVVHKKNGVIMARKLVHLEVKPSVRQQIVKELAVLHKCNSPYIVGFYGAFIDNNNSDISICMEYMDGLSLDIVMKKVGRIPEKFVGKISVAVVRGLAYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYSIQSDIWSFGLSLVELLIGRYPVPSPSKLEYSVMFGIPESQLQLADGRNDVTLYQASNNPAAMAIFEMLDYIVNEPPPTLPKGVFSDEAIHFVSKCLKKMPGERANLKSLSSHPFFMRYADVDDNGEFANFVTETIQIQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUA7</accession>
    <name>A0A0D8XUA7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716376">
        <property type="protein sequence ID" value="KJH45966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUA7"/>
    <dbReference type="STRING" id="29172.A0A0D8XUA7"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="38716" checksum="3F00DBF22D12FCAE" modified="2015-05-27" version="1">MVDTVPYFLVKTVKNFLCLSRKYRKCSYELDVMQCYALGSVRPSGISNPSKLVAVKTEKYSKSMLHVEVGVLKAAKAAKAKHFCELIDYGSNKPDYVYMVMTLLFKDLHKLRSEMPDRRFSMSTSIRLSMQAMKAIEELHKLGYISRDIKPGNFAPGQQCNKQSKIIFLYDFGLSRKYMDKNGNIIPARKDVGWRGTTRYGSLTAHQRQDLGRRDDLESWFYMIVEMARGTLPWRLVTERSAVCAAKQAARAAGRTQFLYETPKQYDQILTTIDSYTFESQPDYERIYKTLDEIREEKGIRMQEHWDWEDESSFSTTNTVTSYSARELKAKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUF1</accession>
    <name>A0A0D8XUF1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUF1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="10973" checksum="EB6471EC20C30C14" modified="2015-05-27" version="1">MDTFVHTLFADEILGNFILEYIRPSFLEEVILLKSILSTFLLRIVSGLHSVLFPCGLVLFSEIERCLILTHYSAAQFNLLIALCASSIICCLSVDCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUS9</accession>
    <name>A0A0D8XUS9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUS9"/>
    <dbReference type="STRING" id="29172.A0A0D8XUS9"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="180"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="482" mass="55114" checksum="7A3299AA94ACCF31" modified="2015-05-27" version="1">MKSLCCVVQSIKRFSSSQRPVVKLNSDRFGSLFPTDIRVERLRWIKNSDFDTPTPSRTVKELQVPLSLPKKKRERVIKLLNSEPEPSTSHHCLIECSRQEFNLYENQLGKDTALCSQFWKKSKYCDDWFVIKRRTKIAKQFVEWGNSWECYVPDRLHPTVKNVLEELKLEKPTYVQSQCLKMFTSPHHLFIAAETGSGKTIAYAAPLVTRLCCQKQKGVSEKAIILAVTSSLKAQISDLLSKFVSNTNLTVATFYSKADVTDDWDILVGTPGQVEKYLRKSKQLHTVKHLVLDEADMLLDESFTDALTEIFSLIPIAYSVTNTVDMSSGARIIFSSAICPEQLQNIADAVVDRQYLTYVKSSKLHFLSESIEMKFIRVRETDKINRLKELLVHDMSRGELNETIVFCKNRATASYVHQQLRSLQYEVVLWRSPNDGYDKTSRIFVATDALARQIFNLASRLGRPLANIEADIAGKIRRLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG3</accession>
    <name>A0A0D8XVG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716261">
        <property type="protein sequence ID" value="KJH48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVG3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="18058" checksum="E22AA53788EC8363" modified="2015-05-27" version="1">MILLLFILFTITFALERKNLNYIRDGEAKIEATSLSYIERTKPLPSYVYRHDPDMKFIYSNYMKHKESSAVLDSDRSDEFISNKRSDVNWSSTNQESYKQTEPETSSPTKYYDLRPMEKQKSHYDRTDVNRVLTQLAQQKISKIEQNVLAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWK0</accession>
    <name>A0A0D8XWK0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716253">
        <property type="protein sequence ID" value="KJH48885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWK0"/>
    <dbReference type="OrthoDB" id="5825164at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23017">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="7TM GPCR serpentine receptor class x (Srx)" evidence="2">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="23527" checksum="818DE55A8B025E23" modified="2015-05-27" version="1">MSCIIASMLDSDVYVIKLKKIQSQVRNLDVYYELINARIGLLIILFNTAVYLGNVMISISRMITIVFPSKTHWYSSRNVQLILFFISIISVSNSITYYPEGCWIFFNSTTLLFEMSHTRCAENLSFYGDFLLGITIFTISFIMDMISIMFLRKMRRRIANTISIMKNRQRFQREVIMTAQLQVKRFLKALKLPDILKMISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXP3</accession>
    <name>A0A0D8XXP3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716264">
        <property type="protein sequence ID" value="KJH48539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXP3"/>
    <dbReference type="STRING" id="29172.A0A0D8XXP3"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018592460" evidence="1">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17307" checksum="3106719101B736AE" modified="2015-05-27" version="1">MPLARNMCAAHIFTGSCWAFGAVEAMSDRICIASMGKIQVPHRTNSKSYKKKLLNLSIMLSRCDGGDPMAAWKYWVREGIVTGSNFTENKGCKPYPFPPCEHHSNKTHFDPCRHDLYPTPKCEKKCVSSYKQNDYEDDKFYGKSSSIIANLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXR2</accession>
    <name>A0A0D8XXR2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXR2"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
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        <property type="entry name" value="GILT-LIKE PROTEIN C02D5.2"/>
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    </dbReference>
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        <property type="entry name" value="GILT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336048" evidence="3">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="25957" checksum="F75788616C3D0841" modified="2015-05-27" version="1">MAFIIASFILLSTFDDVASNKSITKLTSDFADNTIIDQNVNVVVLEIVGASTCPDTTRFLTTQLMPSFKKYTNRIQINYHPFGPFNYTKCTEEFSEVKCECQHGKNECEKNALQACIIETLPTVDDHIDIVGCIQGSASFNDSLTDCLLKKRSSTITSNIVNRIRQCATTNDGIRLMADHGIKAAQLLKNIDWVPWISINGLRIPSAEKHLEAVLCYQYFDPPPIECENLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYG7</accession>
    <name>A0A0D8XYG7_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF39">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="37342" checksum="00EDAAF6F46DBFC4" modified="2015-05-27" version="1">MIFTFQILTETSATVFSSFFSAICILSATISLLTICSSNSSASEESEKNVEQKPPAGSTSSTIPSKELGKSSTETKTSSQSKEMKKAPLRLPQQMPSPSLQQQQQKPLNKLTVNEQQRLAKNQINQGKLARKAPKKETVEAFTVQDNVTDFIEAARTTNLPATKKENAPPSDTGDGNYEDVNLAQAAPEQPRRVVTVDPTAARFPTTGGKSTFTVLNAGTEHVVFKVKCSNNKDYRIKPVYGNLDPGGTHLVWVVRLPAGVMEDRMVIQWLPAPPNVTDPAALFKTAKTGSIQSVVARLIGVSIESPQVNLPDEKTARGNISVVKPLPPGSSPDAPKSLTGGSMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYI8</accession>
    <name>A0A0D8XYI8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">7 transmembrane receptor</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG20548-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="78"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="118"/>
        </location>
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            <end position="276"/>
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            <end position="302"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="34798" checksum="382BDAFA927619CF" modified="2015-05-27" version="1">MPCLKPAELRFVHDHLTRWLWQYLFPLQFTLGVLGNILNLCVLASDETSNVASDLLTAVSFCDLAFLLVMLPHALSSYDILAFNDVFRFFYLKSKQHIAAIANWMSAAAIWLILAVSVERFLIIRSPLRSKLYWQRGRMVLVLSSIFFATGLLTLYHHFEYDCTLMEFCNGSQLIDFCYYAGEKHPRTFLKKELILPSEAKKLYMRIMTIFNAVLVVFAPILLVIILNMLMIRELHFNDKSILKFRESITTNQHRQRSRVTVTVIAIGLCFSLTQGPSAVMVIWELFAGYAHLGSTFYAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYJ0</accession>
    <name>A0A0D8XYJ0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional purine biosynthesis protein ATIC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">AICAR transformylase/inosine monophosphate cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:22193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate</text>
            <dbReference type="Rhea" id="RHEA:59144"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57452"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:59145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:18447"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.</text>
    </comment>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYJ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XYJ0"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="14684" checksum="C327D656279EF9EB" modified="2015-05-27" version="1">MATEESLVVIFSVSDKTGIYKLAHGLVDCGFTIVASGGTAHVLREYGVTVKDISEITKFNEMLGGRVKTLHPAVYGGILARDTEQDRREMEVTDDCLKLIRQYGAVEASDKYRLTSQHAERYRELKWEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYL5</accession>
    <name>A0A0D8XYL5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYL5"/>
    <dbReference type="STRING" id="29172.A0A0D8XYL5"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000002">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="311" mass="36134" checksum="F1CD9C072F18D956" modified="2015-05-27" version="1">MSGNFSEMILLEQNNRVIMEFLELKFTNAKEGKKLENVNVEFADFDGVTYHISNPDGDKAKIRLLRREYDSYLVTPEPGYNVSLLFDLTNLPDDHAALIQKVSALKRNCFASVFEKYFDFQEAGQEGQQRAVINYRKDETMYIEAKADRVTVIFSTIFRDPDDVIIGKVFLQEFREGRKASQTAPAVLYSLGEPPLELRDQPDARVGDNVGYITFVLFPRHTNRKARDNTIDLIHTFRNYLHYHIKCSKPPMHPLHSLLIDNVLPIVTSRLFKVYLHSRMRSKTNDFLKVLNRARPEVKWPFVCAQLERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYT3</accession>
    <name>A0A0D8XYT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_04190</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYT3"/>
    <dbReference type="STRING" id="29172.A0A0D8XYT3"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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</entry>
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    <accession>A0A0D8XZV7</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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    <feature type="chain" id="PRO_5013288923" evidence="1">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15728" checksum="13E29CA3F22A5D50" modified="2015-05-27" version="1">MQTLIVLLLIYGAVAQRRLCEAEGTCRQCADTRYSYYRCTQQEDCFLGEICDRGFCCPNIRPIVGLQSEIQRFTQHSTNEQMLLNTHKPENSDIIEDKLCPDGSESTKRCRLDDECVAVNELCFEGKCCASEFKFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1E8</accession>
    <name>A0A0D8Y1E8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminin G domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1E8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1E8"/>
    <dbReference type="OrthoDB" id="5836593at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="146"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="325" mass="37305" checksum="AB9DF6EA7598BE21" modified="2015-05-27" version="1">MRTKQANGIIWIWANYKNFTRYFYMTLLDGFPTIEVKGRHPEPKILRNEERRLDDGHWHDIVIVKKERELILTVDELLPISITDCPTPKVMRRRMYFGGVISKHRSSFNLQIPGYNGCLKALKVNNVTQILESDSSRDVVPCARPTKGMYAHQGGFVVFENLQKSMKDGSRNIDISLTFRPIVDEGTVLALLTNSNPETARLTIEIKNDKLFVTVIHEASGLNILDTISIQRQVCDGTWHTLRLLIDYKIMQITIDDQRNKLPIDRISSEARDLLLNLPVNIAGVTGKCFLFENLLTPLLRETFAFVFSFGSREVFDEFIGWMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y305</accession>
    <name>A0A0D8Y305_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENP-B DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y305"/>
    <dbReference type="STRING" id="29172.A0A0D8Y305"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="13835" checksum="73D9BB3C8624DB55" modified="2015-05-27" version="1">MEESANATDVIQMVNTNSIDHERRKKKPYKELTLHEKVQLIRLAEENSGMSQAAIAERYTIAKSNVCRILQRKKEYLMAYESAGYAGSRKRKLKGPQSELDECSRTGLLMAATAQCGKRQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y341</accession>
    <name>A0A0D8Y341_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y341"/>
    <dbReference type="OrthoDB" id="5840146at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9597" checksum="82521CA3A2A415CB" modified="2015-05-27" version="1">MPSLDCFRCPFPITQTALSGSTQLVIIIVHGLNWRMGTVISQFGFNQPFLLALIGLLWQREKLHLSLLIDIHLADNDELSKIFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y352</accession>
    <name>A0A0D8Y352_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y352"/>
    <dbReference type="STRING" id="29172.A0A0D8Y352"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="630" mass="70700" checksum="33F632213A691CB2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y357</accession>
    <name>A0A0D8Y357_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716201">
        <property type="protein sequence ID" value="KJH50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y357"/>
    <dbReference type="STRING" id="29172.A0A0D8Y357"/>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000006">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Beta_helix"/>
    </dbReference>
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        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="751"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="751"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="844" mass="94186" checksum="78C81CD15F709875" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3F8</accession>
    <name>A0A0D8Y3F8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation elongation factor EFTs/EF1B dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3F8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3F8"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="3">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="22597" checksum="8565C4CED20F2BAA" modified="2015-05-27" version="1">MIRRNQDLDSFSDPNYKSLREIIAMTVGELGENISVRSMVALYAPEGASLYSSAHPKDGSDAVDMGRYVSVVALRRCENKELFPTEKLANQLCQHIIGMRCDTLGTPPHSTEEPEHLIGMQPDTLGTSQSNDADKVETNTTDAENELNNFAEVQSTNINEEETALLRQAFMFNPSQTVYDYVQSHQAEIVDFFRHELYNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3N5</accession>
    <name>A0A0D8Y3N5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin--protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="4">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
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        </source>
    </evidence>
    <sequence length="430" mass="49117" checksum="368E3E604B6F665C" modified="2015-05-27" version="1">MENSSDEEFYDADEELIDLDKAEVAIPDVSMKDMLYEEVDNFDFGDSHEDFDAIYNNAEEHDVGNVQQEHGSVLVHLLSQVSIGMDLTKVTLPTFILERRSLLEMYADFFAHPDAFVVTVDLKSPQDRFVSVVKYYLNAFYAARKSGVAKKPYNPILGETFRCRYNVPGLPPIGKKTESGPFPGSDENQLTFIAEQVSHHPPVSAFYAEHPGKRISFNAHIYTKSSFLGLSIGVANIGNGTVTLHDYDEQYTVTFPNGYGRSIMSTPWVELGGKVKITCEKNGFYADIDFLTKPFFGGKPHRIQGNLYKDGSKKPFMTIRGEWNNLMMAKPAYGDEYLFIDVKAQPEMKKECVPVMQQGERESRRLWRHVTAALLRDRINIATTAKRLIEQRQRAEAKQRLEKGERWKTRYFTLVSNNNWIYNDPLGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5D8</accession>
    <name>A0A0D8Y5D8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5D8"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336207" evidence="7">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12349" checksum="E9FF7CE2398700EF" modified="2015-05-27" version="1">MSNIIRLAGLSGVLAVAVGAYGSHKICDDDKLDIRRKKAFETGSRYHLIHSLALLAAPKARYPYVTSLVFMSGIIMFCGPCYHYSITGEESVKKYTPIGGVLFILGWLSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5X9</accession>
    <name>A0A0D8Y5X9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5X9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5X9"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="3">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="560" mass="63093" checksum="0E36D7B771E2498B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Y5</accession>
    <name>A0A0D8Y5Y5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laminin EGF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5Y5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5Y5"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000974">
        <property type="entry name" value="Laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="18506" checksum="E144DF4109562F11" modified="2015-05-27" version="1">MEDNVRSAHVRSTPTRAIRSVVRAQTVRYDKHKQFGSIAHNTTGVRCELCLPGHYGNPSLGGEMGACRPCACPTIENSHSTECVMTQLVVAGPAASQEDAYVCTACDRGYEGNKCEVCADGFFGDPMEINGTCKECECNDNIDLMAIGNCDTKTGICLKCIGDTRGEHCEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y611</accession>
    <name>A0A0D8Y611_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y611"/>
    <dbReference type="STRING" id="29172.A0A0D8Y611"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="374" mass="42649" checksum="CC200F6DD58121D3" modified="2015-05-27" version="1">MRRKKKNKKTTRRRKSVEVSPLSATKTHLDSKMMGEIIVVDGVKYRRRRKLGSGGSGSVYEIQREDNGITYALKEALLRQNGNIYRGEAERLQSLRNAPHIIDLIAYDFTTNEQMLRMVLELGETDLERELKLQKGKFDEDTIRTFSLEIAKGIKEMHDHSIIHLDMKLANVMFVNGALKIVDLGLSATIPNGVASFSASDYVIRDFMFGSNRPPEQIVPRSDGTYKLTKKVDIWGLGAVVYQMRYGRKPFTDCPENTVSFSTYIYLTLYKFHKFTSLLFFILSYTKMVAVLNPNVRLQHDIGADRAMTEFLEMCTIRDVEKRATIEQLLGHRYLAEAFPLTIADDVTATSPNNQKSESSIRMQLLADTQSKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y626</accession>
    <name>A0A0D8Y626_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">IC domain protein, HAD ATPase, P-type family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y626"/>
    <dbReference type="STRING" id="29172.A0A0D8Y626"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000098">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336363" description="IC domain protein, HAD ATPase, P-type family" evidence="10">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56724" checksum="AE216112AF8979F4" modified="2015-05-27" version="1">MWYYSLFTLLMLMTFEATLVKAQLRNMQEIRNMGNKAFTIQEPIEDFECERYFDIDSDSRLHVIFGGTKIVQHSPPGKGMDVLKGPDNGCVCYVVRTGFNTTYFPGSKDEKRNKYKLFLECTLILTSVIPPELPIELSLAVNTSLIALQKLGVFCTEPFRIPFAGKIDICCFDKTGTLTTDNLVVEGIAFSTDKEKGFYETSALACCHSLIRFDDELVGDPLEKACLSWSDWSLTKGDSVLPPKGSKQAGLKIFHRYHFSSVMKRMTVIAGYQLPGFQEPKLIVAVKGAPETLRSMYEVLPKDYDEVFTNLTRQGARVLAIGIKDLEQTRLSEIRDTKREVLESNLRFAGFVVISCPLKPDTKLMIKEIIESSHKVAMITGDNALTACNVARVLRFMKKKAVDESIEYDVIPYANEQQLKSFFLENEFCLTGPSFSYLLENEHEFLRDLLMYVKVFARMAPKQKFYLQERVINEYKSLGYITLMCGDGTNDVGALKHSNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y792</accession>
    <name>A0A0D8Y792_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a homohexamer that can probably bind six kinase subunits. Interacts with cdk-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y792"/>
    <dbReference type="STRING" id="29172.A0A0D8Y792"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="161" mass="18514" checksum="62438568C9100172" modified="2015-05-27" version="1">MPFQPEVIEYALLVTTCSSAHEPCSSLKIKYVLGNKLHTTTIHMAVAKFAKMVEDQVDMVSYIRTLDMTTGQNDFYYSNKYEDDEYEYRHVHVTKEVAKLIPKNRLMSETEWRSLGIQQSPGWVHYMIHGPERHVLLFRRPLPNKSNVAGKSAAQAQVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7D7</accession>
    <name>A0A0D8Y7D7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7D7"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="173" mass="20856" checksum="251DD3C3F361399C" modified="2015-05-27" version="1">MGDTALQTAVHRTVPVADQSQKPIKCIEKFHILYKRYHIKYLFPLMFIMLYMVFGSVIFYLLESSTDQNTKNEQYGIYMKMNRIELHLKKYQLHEVQAYKWTAVHRTVPVSDQSQKPIKCIEKFHMLYKRYHIKYLFPLMFIMLYMVFGSVIFYLLESSTDQNTKNEQYGIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7I5</accession>
    <name>A0A0D8Y7I5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_03235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7I5"/>
    <dbReference type="OrthoDB" id="5809216at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F13G3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="56685" checksum="340CE8D09E429F74" modified="2015-05-27" version="1">MVAWNNETNLVTHGRMERITPHNVCRWISIFMTTPLLPNLQGLALSVGNKLIEIPFREPVLKQYDVVTCIAPLFGSEQWQQALLAAHVYRRLLKANCCLYRFGTHMHLYVRSMVSPVYKLLKIYEEEGYLTIQPWLRITLRTISELQFNPNVNVEFRNQAAAQTDCLLQYKESASYIALMDLDDLLIPRMGDTYLEEFAHLFNSMPNVAYLHYGKENTKLKAVKTATQFNLMETMSSIQFVQVSETGKVVADPRYLNTTWIHFPVFIAKGMERYNVPLHVNAITHHKHVELFNLMETMSSIQFVQVSETGKVVADPRYLNTTWIHFPVFIAKGMERYNVPLHVNAITHLKHVELVTSINRSTLSQKVWFLPNTVVEVAEQELIEKRNINEIQKDFERMRNRADVAKILPSLPTSYVYLKAIAQCFQETFYKLHYSGRNAEIKCPGPDRCLFPRGVPCYNSVAEFHSIDDGSRINLHFATDAKFTEQDGCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Q2</accession>
    <name>A0A0D8Y7Q2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trehalose-6-phosphate phosphatase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8J8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="340" mass="38446" checksum="182A7B68C8E74CC4" modified="2015-05-27" version="1">MLNLVVQQCQTKHTFILVHLKTVMMILDHISRPVPLSHRKIAYFNGILKYLSSKSNDAEDETEEDFSRNSSSTEESCSQRNVYESCIPSPSSINSNRPRLRSMSRLSKKQEEKNIELPTKLSRQSQMDSLSHGKRNAEQCLSSTDQLREQESIQRRKSLRSWSGKSKKEDGGNATQNCTTKDMSEIPSINVQSLRSHSDAGMSKTKSRSRVEISDSSVGNSSADEASFLSNGKRRRVLSRSESKNYQKPDLSSCKNRGNVAEKCSREVRLLRSLNMKDVNKSVDNSGIDEYIYSIDNSAIDKEGDRLKEFRILRSRSSFPPMEPVHKERTVAGAVDDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y923</accession>
    <name>A0A0D8Y923_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y923"/>
    <dbReference type="STRING" id="29172.A0A0D8Y923"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000072">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="27214" checksum="E76910D63FEFB752" modified="2015-05-27" version="1">MSRGSSAGFDRHITIFSPEGRVYQVEYAFKAINSTNLTAVAVKGIDTAVIAVQKRVPDSLIVADSVTSIYQLSPTVGCCAIGMIPDCKFQVRRAQMEAAQWKYQNGFNMPCELLAKRMADKNQYYTQNAEMRSLGCAMIMISFDDEDGAVVFKVDPAGYYRGMKAVSVGVKQVTASSFLEKKIKKKSDLSHDEAIQLAIETLQSSLGIETRSKDLEVVVVSKKDPNFKKLTNEQVDHHLNAIANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA21</accession>
    <name>A0A0D8YA21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IC domain protein, HAD ATPase, P-type family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA21"/>
    <dbReference type="STRING" id="29172.A0A0D8YA21"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000034">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26588" checksum="BC5A18F7792EEE7D" modified="2015-05-27" version="1">MKGQLVRSIMYPKPVDFRFTKDLFKFVGFLGCISLCGFVYTVVIMFLRGSNLRRIIVRALDIITITVPPALPAAMSVGIINAQLRLKKKDIYCISPSTINTCGAINVVCFDKTGTLTEDGLDFHVIRGVIPACSEHSPMFTAEFNEMNRNELPEKGDLVIAIATCHSLTRCFSTRSIQKINSVLHGDPLDLVLFQQTGWILVEAGDGESDHDETELYDMIQARFFQRIVYNCDYYR</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
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            <begin position="39"/>
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            <begin position="61"/>
            <end position="77"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="192" mass="22383" checksum="C0D879508A5C6827" modified="2015-05-27" version="1">MAHQLFRSSDEDSEQYTNDDTTDIERAFSELSSYYSDMTSSSSEITSSDIESSHDTSKSCDDEETTNFETDDADDTSDYSTHSSDTSFQLSTLIEETNREKLAEFVRLRPADQQWIRAAWTYFDAEPTYRRNFKAVKVARKMRSDLKPKNNWTELYREYFLRHPLNLDSKSIDELKRLSFDAPFLPLPDLTV</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="68" mass="7299" checksum="3BD1A101726DD047" modified="2015-05-27" version="1">MKFAPTGKLQCLLTTCPESFAIYGYECCGSSSEQCCGSVSNLGWVLTGCGVVVTVLLVMAIFSSFFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB73</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
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    </evidence>
    <sequence length="321" mass="33567" checksum="1E47E5CEDF890D7A" modified="2015-05-27" version="1">MSFSCGEHLEAVRKEMTVLANQLQMSKQEVEKVKMETTNFQQQLSALSEQALQSQMEIVKNQEATKRLHHIISSYLPMLPPEYQAFALGELEKIRRDEAQSQQAQAAMLMGGMPNMMMARNPMIMAGMGMAGLSGGATASPRMTKPSGIPNGAQSGMSASVANGMAAAAAAAAGMTGMPPAMAAAMHIPHQQAAMLQAQMMMAAGMGMAMPGLPMPTGMGMPHTMNGVMPQMMPPMSVASGMFPNLTSQMNVSVSIPSRNPSNGALSAAHASATNSPRPAEPLTPQSSIAAPIAVAGSLKEERAQSPPPKPCAEENVSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        </source>
    </evidence>
    <sequence length="106" mass="12256" checksum="0B6F0E517AFAD938" modified="2015-05-27" version="1">MYLPTYLSVFISWIAFWIDTRALPARITLGVSSLMALTFQFGNIVKNLPRVSFVKAIDLWFFVCVAFIFLSLVELAVVGFVDKISEIKRRSKRLRSKREAESTLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBP0</accession>
    <name>A0A0D8YBP0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBP0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="81" mass="8832" checksum="0416284259F18E0A" modified="2015-05-27" version="1">MTGSFYAKAASQNVFGANKGLYVGSVALKKIHKSFKFVLAAPELTTYRSRLDAFTDDSLFGFKNPSTNPTAILNEPILVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBS8</accession>
    <name>A0A0D8YBS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBS8"/>
    <dbReference type="STRING" id="29172.A0A0D8YBS8"/>
    <dbReference type="OrthoDB" id="5877673at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="326" mass="37376" checksum="E44658C46211690A" modified="2015-05-27" version="1">MLFVYLKSSQFKPFFKVLYFANYDEAVQAMRTLLALVIPLVFAKLDLSHVRAPGMYPPEETRTDVPDIPLNSYQMTMTDISGDFNNYQYYYEKDPTPASKDSDGHGSVNKGPIPPQTSEVRQQINVSTSYANIQGGPPTVDDTSPLQYVSPPSRPSTENKKTDEAVEWTPQQNRPASPSDVGDVYRDRPQYSNFDEKIAIKVPVKTDSYKQDDTEYMIRMCNQSKKTNCPKSNRSFYYYPRRKQYGSVKNIISNQQKRIHSSNDFERRQSFDRTTNSYDERPHTGNTRTQINSEWTNSRIATNDGYVGKVGIWQESKHSKSVIEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC03</accession>
    <name>A0A0D8YC03_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_01685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC03"/>
    <dbReference type="STRING" id="29172.A0A0D8YC03"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF7">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="102"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH52106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="396" mass="46576" checksum="17E6AA76EE1AF3EC" modified="2015-05-27" version="1">MTSLYTRIMAKNRIDFLNYLGAIKSRIRHTLKKRRCKSIHIVFVWMFFMFAYFIYKIQYKTGIEILPFIPIDDSGFMIYNESLLNYAKVSEAALQQKKRGFILCWVMTTSINHKTRVQAIRSTWLNRCDASHIFTNSDRFLDKSTPYHTIFSELPMSYFKLFWKTRLALYYLYTNVSSEFDWYFKADDDTYVIMENLRSYLSTFNPDEPLYLGFRLKRRMPNHGYNAGGSGYVISRAAMKIFAEQLFHAKSLCPYHEWEDLAVARCLESVGIYAVDTRDEQRRQRFLPWNPEYHYNGDLIKFFLMDPIEFRGPDIFHENLISMHHLDPSVIRLIDGIIFGVASGGPDIFHENLISMHHLDPSVIRLIDGILYGVAAGMWNRSTVVEQTLQRPPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCI1</accession>
    <name>A0A0D8YCI1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_01478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCI1"/>
    <dbReference type="STRING" id="29172.A0A0D8YCI1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000355">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH52276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="389" mass="42824" checksum="043F9091F2EC7465" modified="2015-05-27" version="1">MKFSGGLVSTFPSGLAIDRFSIRHLLLVSVLLLSIVSIMVPFLAEYLGPFAVIGLRFLMGIGEGMMIPGINGILGNPIAAEFCASTFRWPAMFITSGLVGFLWCIVWHFTVNNSPTNSKWISDHEVMYLQHHLPEKQIKNEKKLIPWRLMACSAPFLVVLYSGIIGNMMIAMILVYIPVYFKDILLLEVKQNGFYTALPHTCNLISKLIWGFLMDSLKRKKILSATHAVKLSQVTSMSIISVSFLLLAYGVDCTSHGLALFLMCCIGTAFGLSISGFLTSLLSLAPNFIGIISSISQIIGFGGRVATPQIITHFKTVGTPEEWRGILLVYSVMTALSAVLFLLWGSGEVQPWNSYRGKEVKLSDLQGDSKRLVECEANAQSELQAVTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFQ5</accession>
    <name>A0A0D8YFQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8YFQ5"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="394" mass="44227" checksum="EC8A6F0E454C9876" modified="2015-05-27" version="1">MRQARIADTAKVRASECRRTGSRIRRTSTHAAESAESGSVIAADMPFIGRDWRAPGETWVRTPHTNGWERSKLRPIQLVSDAIPIPGALPENEICHTNSSTSLLSLDSGSGSRSGSLSEDPISELEDGWIPHCFVKSKSKEFIGCTSISEAFHRLDLARGVSDVRRFSYIAKVVEILVQEKVQNLSGNARKSLVGILTAIVLRSSEEDVHISTARDLVQQFGQALEGHVCGSPQLVSRHQHTANSLLDVISDRQPKTVVSADETSTTFLDLPREILSLVLRRLPDDRSLLETAKAHEALQSIIDRESCLWQSLCEFHFTSFQIDQRKTQEKTWRQTFFELKKYFGIREVYADMIQICCHCKALFWKTLGHPCLRPGSPSVRVTPQQFVDMLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6Q1</accession>
    <name>A0A0D8X6Q1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717635">
        <property type="protein sequence ID" value="KJH40178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6Q1"/>
    <dbReference type="STRING" id="29172.A0A0D8X6Q1"/>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLAC" evidence="3">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="193" mass="21656" checksum="725E9030470174EF" modified="2015-05-27" version="1">MARISAICQMNYFVVFCECKAEWHASDWGSCSSNCGTGGVQLRLLSCVWTITRLPAGRNCEGRRPPAARSCPHADSLPPCRPTALPLQQDESCEDNSRYCDIIKLRLLSCVWTITRLPAGRNCEGRRPPAARSCPHADSLPPCRPTALPLQQDESCEDNSRYCDIIKVFHSCDSEEVRQKCCATCKYVDNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X865</accession>
    <name>A0A0D8X865_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717028">
        <property type="protein sequence ID" value="KJH40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X865"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15956" checksum="B61A370990B536F5" modified="2015-05-27" version="1">MGSSYNEKRRRQVDEQDFRMVPKRIQTLYWATTCKMGGRAVKLYSQLKTILELRNGQHQCHHGENVEENLERCDCVMCGNVDINEKQLNLDENILWRNKIKKKREYYSVGKIRCDSEYSEIKRSTVVVDMTEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8B6</accession>
    <name>A0A0D8X8B6_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717015">
        <property type="protein sequence ID" value="KJH40783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8B6"/>
    <dbReference type="STRING" id="29172.A0A0D8X8B6"/>
    <dbReference type="OrthoDB" id="10651481at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="39057" checksum="D2445F8FD2C8E7CB" modified="2015-05-27" version="1">MNEKCEQKYNVRAEDITCANVSEVIHRLCHEYLSNGNNASILYYRGDDADERYRSVNHVIQDDVLEEMRSRYGPDWLNRAGFYNMEHVRGFVGHMITLVFKEYMQRQEEAEQFEQRINRAFKQQLEQNMRRMSQMYSSSYLRCGMQYLHAMNAGDGMPVIPPQGNSFMGTPPTPPFMGAWPNTPFMCGQTSPPFMGRQPIPSLMGGQPIPPFMGGQQTPPFMGGQQTSPFMGGQQTPPFMGVQQTPPFMGGQQTPPFMGGQQTPPFMGGQQTPPFMGAQPIPVFIYAPLIPSYMGAATNHPFMGGQFNLIFQPSVRICHDHHLPDCPQCLDEPAQQPLDPQWRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8R8</accession>
    <name>A0A0D8X8R8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718398">
        <property type="protein sequence ID" value="KJH40029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8R8"/>
    <dbReference type="STRING" id="29172.A0A0D8X8R8"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="10751" checksum="968D2303912FBC11" modified="2015-05-27" version="1" fragment="single">MPAFSPTMSKIGGKIVKWCKKEQDRVEVGAVIAEIETDKAIMEFESVDEGVLAKIRVPERTSGVPVNQPIAIMLEEGEDKSALDSYVLASTTNVESHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9S1</accession>
    <name>A0A0D8X9S1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716853">
        <property type="protein sequence ID" value="KJH41308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9S1"/>
    <dbReference type="OrthoDB" id="10597243at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="36650" checksum="39FFEF5782B1EAC5" modified="2015-05-27" version="1">MLVIAAHSPHYKEPCPVIDHSANKNGPRTPSPDIMRKPDYNAEIERLKKDIEEEKRRADLQTKLDLLELKFQAKLREKAANDSAPKDKEGEPRTPSPDIMRKPDYNAEIERLKKDIEEEKRRADLQTKLDLLELKFQAKLREKAANDSAPKDKEDAIPSQNAAKIDSSSGLEGPSQSCPNDSDAMDVDGGESEEERCDEAENDRIAGTDIQMTTESVPIDKSQGGFANAIKGQSDNVTGQPPQISPHFNFMRGLRGGPPRAGRFGFSNVPGPTVRSRSGFFPPRMRGVVRGAPNLRRGFPKTGGFPPPMTPQPFRGRGGGFYGGRRAGPRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA68</accession>
    <name>A0A0D8XA68_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716819">
        <property type="protein sequence ID" value="KJH41463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA68"/>
    <dbReference type="OrthoDB" id="5856355at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="34260" checksum="A816991BE74D4EE6" modified="2015-05-27" version="1">MRNSDVNVQLSIAQIRRLKERVELCGRRLRRLIDENEKNEDRLQQMRKRAATLDCDLKRRLSIGKYGNPEVEGVILRELEKPLDYEIETAGNFQKKMAHVRHLMAKLLVRTSLNEWAAQQEMAEQEREVTARIRDASNARQMLRDVLMESKKKAEGAMIERKNRYEELQRLECQYETCAAGAWLAITERNRLSDRLAILTKQPYITYWKGEDNYDEPQQEKNNAECNSGMSQSSSYPASGGSAFTVTSKQQFVSDSEKSEDREMISQKGEVFVPFNITTTIQKVLHDSLGLDVEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAN0</accession>
    <name>A0A0D8XAN0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, iron-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="Cys_repeat_1"/>
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        <property type="entry name" value="Kunitz_BPTI"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="968" mass="105366" checksum="01A3DA6E3E1A559C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBJ8</accession>
    <name>A0A0D8XBJ8_DICVI</name>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716894">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <position position="76"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00035149"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00035458"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="76" mass="8533" checksum="5ABB9C33A912CD20" modified="2015-05-27" version="1" fragment="single">MVMSDIVTIRTRKVLSNRLLYRKQMVVEVLHPGRATVPKTDIREKIAKMYKTTPDVVIPFGFRSAIGGGKTKGFAL</sequence>
</entry>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718322">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="35" mass="3783" checksum="723321B5DB50FC5C" modified="2015-05-27" version="1">MKTFYNYVGRIGTDIIMVATYSAMPSLATLIGNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCE4</accession>
    <name>A0A0D8XCE4_DICVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="37624" checksum="FA13CC0BCE43AE57" modified="2015-05-27" version="1">MLQECNDFQDTVCTGDLQWTVFEKLLEILIILLSRLKAECCTHHAMSQSKFINTVLLGEYDKFEGGVVRTSDHTASFDLIKEVRKLTTDANRVQYIVTVHRVPCHPVLPNNKYLSSRRKREMHELKKKEDSHDFIFDGTRKREVFDDVKRPLVQRHSLAKRRRSLKDVHDKDYNKYDYDVYVPRAISNAIRFGKQPIKKRPDSSVRVHADGGLYQPKKAAEIKVPPNSPNVINGLLPSQSVAYENNREPQQYNPYYWISNQYPSNSPTSYDGQPQYFYYTPANTFHTPYYYYNYPSSAYNYVGVNFFNVTVFFESETYLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCQ3</accession>
    <name>A0A0D8XCQ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="72" mass="8337" checksum="5407F4EC38584DCF" modified="2015-05-27" version="1">MEGGLGKPGGGPKPIWPRVLQSVQSEAELFLDDDNFAYRVSPYRDAASLIRRMDKQENYDKVMNFLEKYIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDS0</accession>
    <name>A0A0D8XDS0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">HannoverDv2000</strain>
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        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="42733" checksum="CDF2361EBCF88EAF" modified="2015-05-27" version="1">MWRQRYANELHCITNTVDTSMSVSPEIIKKIEDGYTKLQNAQDCHSLLKKYLTKSVVDQLKDKKTKLGATLLDVIQSGVANLDSGVGVYAPDAEAYTLFKPLFDPVIQDYHNGFSPSQKQPATDLGEGKTTQLVDLDPEGKYINSTRIRCGRSLAGYPFNPCLTEANYLEMEAKVKKIFENITDPELQGTYYPLDGMTKEVQNQLIKDHFLFKEGDRFLQAANACRYWPKGRGIFHNKNKTFLVWANEEDHLRIISMQEGGNVGQVLERLIKGVKTIEAQAPFSRDDRLGWLTFCPTNLGTTVRASVHIRLPKISAKPDFKTICDGLKLQIRGIHGEHSETEGGVYDISNKARLGLTEFEAVKQMYDGVKHLIELEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDU8</accession>
    <name>A0A0D8XDU8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein bicaudal C homolog 1 KH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDU8"/>
    <dbReference type="STRING" id="29172.A0A0D8XDU8"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR054727">
        <property type="entry name" value="BICC1_KH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22985">
        <property type="entry name" value="KH_BICC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein bicaudal C homolog 1 KH-like" evidence="1">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="29656" checksum="77632FF2BB8B5642" modified="2015-05-27" version="1">MRFGLLNLGDVANKSDQVSISGSPRNIENARRCLRAISPVIITFDLPWIFPYEPDFTQIPAEIAVTIRVVTPTLYSFIVRANAGDDQIVLHSINLIIEQFHIPKDFPIITSTYFNVKDDIISSLQNGKDTLRLQRLAQHYKVEVQLQNLSQQIQIHGPSNGVLLLRKFILGLSSITLSFDVPLRDFHLDIERIQKEFDVSIYSKKKNNANEILAISIKSVEDNIMNVLRAREFMLGEAMTNYPDNEYIVLETTQCTSNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEA2</accession>
    <name>A0A0D8XEA2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KN717031">
        <property type="protein sequence ID" value="KJH40736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="14828" checksum="479075642B41E85C" modified="2015-05-27" version="1">MIGSKEGDIYSFAIICAEVVTKSWPWNLNNRKEDATEILYMVKKGGHPYTRPELMTDGEMEVNPSLIHLIRDCWTERPSERPTITMVRSQMNSMDSRNGNLMDYIFNILEKYASTLEEEVSETSERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEP8</accession>
    <name>A0A0D8XEP8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11821</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KN716697">
        <property type="protein sequence ID" value="KJH42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEP8"/>
    <dbReference type="STRING" id="29172.A0A0D8XEP8"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="401"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="793" mass="86373" checksum="C4183E054CF63D60" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEQ1</accession>
    <name>A0A0D8XEQ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="10">HannoverDv2000</strain>
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        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
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    </evidence>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="87" mass="9428" checksum="2C54EE58A04E5E82" modified="2015-05-27" version="1">MAIVVTIEVLSNSIDEWNTAVAQASQQGDWDYDAVKVTGYSCRMAQMVVAACLLSAAAFALGSHKQKGDNAAIAEIEIEDRPVHIYR</sequence>
</entry>
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    <accession>A0A0D8XGA3</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="382" mass="44162" checksum="E98466D287BEAABF" modified="2015-05-27" version="1">MRNELERRRRSVASFGGGRRVTTTDLMIRPLYATHRKAYARELKKNFKTWPLMIAEAAKDIEKSFKHRLLFVENVLRFGKMRDVVKEFCKQNKEWVKERLKITDIQNKLFLEGTSLNKLRPFKSPYHLASELHELPPSVGHSVFFCIARKNLTLVIGKEETVRKVTEKGTLPLTIHPTRYQYQPNAVTAYKNVSEFQEPLVISVHEAPRRAPSVNSLSGFSSESGASTATESPGEWQHNWKMQTMHRDLEHRLMDSSIQNPLQEKELGELGTSQRIAEEVDRRIGLLNRGSPRFETFCCGKCNESSKYSTKIYAENMIKLRRNKNAARQIQNDIKKIVMSINSLDVKITKNRLHMQVIDYVFNEMIKLTPTTSGDPYDGYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGA9</accession>
    <name>A0A0D8XGA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716538">
        <property type="protein sequence ID" value="KJH43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGA9"/>
    <dbReference type="STRING" id="29172.A0A0D8XGA9"/>
    <dbReference type="OrthoDB" id="5798238at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="28424" checksum="E4F4F688A6395545" modified="2015-05-27" version="1">MEIIRMCYSVAQKNEVLLRKLEEIFSMNLWLSLTKVIDKNFIVLVINLPFSYIEKKILDDEYPVLFLVSALTKKNYRAEGNYSLRLDDTVSLTRQDHLVQQFSYSDIIWVAIGENLLGIFVENCGLFEFICDQPLLIIAHLRKYIKFKNTFPAVKLDMKRNYNRFYHQEREIIARNLDTSPTSTLESRSITTVEAVQINQSHFFGNEEEKNTNNDIEKCICKIPSRKCSIFSEFFKRFMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGK0</accession>
    <name>A0A0D8XGK0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716526">
        <property type="protein sequence ID" value="KJH43785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGK0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="22646" checksum="20730F60307AD2F5" modified="2015-05-27" version="1">MSDLFKLLLFRIELIEILGKQAKNGRANCSLSENTILSLMLVGSTTYRIKLSDKLQNDSVDSKFALQHTGSSSQTSSKTIALIRSSCALVHCLLRDDTRHDTGLQILSIPIYLWTMQPTVHGSDCDETALWKIHSTFDEIYVYKNSFKVMFPMLEASVEVCVASRILDLCASDNFVVVVTDEHIFIAHKNKLTVSSLMNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHL1</accession>
    <name>A0A0D8XHL1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716493">
        <property type="protein sequence ID" value="KJH44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHL1"/>
    <dbReference type="STRING" id="29172.A0A0D8XHL1"/>
    <dbReference type="OrthoDB" id="5846683at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="376"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="519" mass="58203" checksum="355562FAB12C8032" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHZ7</accession>
    <name>A0A0D8XHZ7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHZ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XHZ7"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590:SF3">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44590">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="14086" checksum="B12600A480809B8F" modified="2015-05-27" version="1">MVYVHGGGFLIDSAVKYGDREEFSPEYFKDMNLFLLLPFKLCLREKYLCCHGVVVVTIQYRLGLLGFFSSGDEVCAGNLGLWDMTMALRWVQDNIKAFGGDPNRVTVVGQSAGGASVDMLAISPHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIK7</accession>
    <name>A0A0D8XIK7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_10386</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="12"/>
    <dbReference type="EMBL" id="KN716544">
        <property type="protein sequence ID" value="KJH43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIK7"/>
    <dbReference type="STRING" id="29172.A0A0D8XIK7"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="2 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="322"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="463" mass="49726" checksum="6C54D5A914FED4D0" modified="2015-05-27" version="1">MKTICVEKDPTLGGTCLNVGCIPSKSLLNNSHYYHMAHHDFANRGIECTAKLNLAKMMEAKASSVKQLTGGIVQLFKANKVGHIEGVGTITGPNQVKVRKNDGSVETVNTKNILIASGSEVTPFQGISIDEEKIVSSTGALSLKAVPKKMVVIGAGVIGLELGSVWQRLGAEVTAIEFLGHIGGFGIDMEISKTFQRCLTKQGMKFLLNTKVMGATTGGDNITVEVEGVKDSKKQKLDCDVLLVSIGRRPYTKDLGLESVNIQLDDKGRVPVNERFQTKVPSIYAIGDCIAGPMLAHKAEDEGILCVEGICGGPVHLDYNCIPSVIYTHPEVAWVGKPEEQLKQEGVEFKIGKFPFIANSRAKTNFDTEGFVKVLADKQTDRMLGVHIIGPVGCVIITNYVLLMFSCVINTNAGEMIAEGALAMEYGASAEDVARVCHAHPTLSEAFREANLAAYCGKAINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIN2</accession>
    <name>A0A0D8XIN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transporter, SSS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_09507</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716471">
        <property type="protein sequence ID" value="KJH44458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIN2"/>
    <dbReference type="STRING" id="29172.A0A0D8XIN2"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44458.1"/>
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    </evidence>
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        <source>
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    <sequence length="357" mass="38928" checksum="2ECAF78244E0C9F0" modified="2015-05-27" version="1">MADVLGVIAIIFFYVLILVVGIWAGRKTKNAKECAADHVGAHTEEVMLAGRNIGTLVGIFTMTATWVGGAYINGTAEALYNGGVLGCQAPIGYALSLIMGGLLFAKKMRNEGYVTMLDPFQIKYGQRVGGLMFIPALLGEVFWSAAILSALGATLSVILRIDMNISVVISALIAVVYTFTGGLYAVAYTDVVQLFCIFVGLWVCVPAALLHYATKDLRRNAEDWLGEIGGFKETSLWIDCMLLLIFGGIPWQVYFQRVLSSRTSSGAQNLSFVAGIGCLLMAVPPALIGAIARNTDWRLTDYSPWNNGTKIEAIPEDKRNMVVPLVFQYLTPKWVAFIGTQYVLSVCFLSCCIFFNY</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="2">Nbr1 FW domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </feature>
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        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="30100" checksum="AEA6A72DEF1E5BE0" modified="2015-05-27" version="1">MDADEVDNILIRQLSCLRTSDKEALVKQFQSILGDVALPPELCAFFLDMTNWNLQDAVGAYYDHGHTNNVGEIGFDLPLLDMQLVKDVTVGEGESVPPKTRFVKSWRVKNTGGIHWPEGTALCFVDGTLLSSDKRVPVVSLGPGGEAELTVVMLSPSLPGIYQSRWQLNTPQSVPFGGPALHLFLEAIWCIISVDAAGILDITQQLANAPLGRLSLPTSINPFMARSTVQSMAEDFIEMEINYRNFESSSPVTIPHENSTDGPPCTPSTPPYERE</sequence>
</entry>
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    <name>A0A0D8XJA7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">La-related protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_09271</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716455">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XJA7"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008187">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA stabilization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="la-related protein 1B isoform X2"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
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            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1160" mass="130547" checksum="7AE37EC4B48F49AA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKQ6</accession>
    <name>A0A0D8XKQ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716610">
        <property type="protein sequence ID" value="KJH42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKQ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XKQ6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
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    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="569" mass="65293" checksum="9865871BDF81F2AF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKR0</accession>
    <name>A0A0D8XKR0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716609">
        <property type="protein sequence ID" value="KJH42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5828232at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335749" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="66" mass="7610" checksum="3D77F655A3CB1074" modified="2015-05-27" version="1">MIAPWLILLIATLVTTSAKSQWRDFPIMQWPDTAAAKRDAGYWNDCEFSPMSCLLRKKRSILRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLI4</accession>
    <name>A0A0D8XLI4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716457">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XLI4"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="10">
        <location>
            <begin position="222"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="35728" checksum="26A322FBAEC4D488" modified="2015-05-27" version="1">MSRVPAYLNVTDIAGLVKGAAEGQGLGNAFLSHVSACEALFHLVRAFEDVDVTHVEGDIDPCRDLDIISEELFAKDLQSLSGVMEKVEKLVTRAGDKSLKVDYETLLKVKKDLEERKPIRLDTWSEKEIEVLNKHLFLTAKPIVYLVNLSERDYIRKKNKWLSKIKDWIDQHDPGASLIPFSGIFENKLLDMPDDEREKYLKENQTSSNLDKIVHTGYKALQLEYFFTTGKDEVKAWTIQKGTLAPKAAGRIHTDFEKGFIMAEVMKVADLMELGDENKVKAAGKYRQQGKTYVVEDGDVILFKFNAGAGLTGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLR0</accession>
    <name>A0A0D8XLR0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716571">
        <property type="protein sequence ID" value="KJH43311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLR0"/>
    <dbReference type="STRING" id="29172.A0A0D8XLR0"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="276" mass="30864" checksum="7F2BAE9BAC2E2D28" modified="2015-05-27" version="1">MMPIRVKQPNMMASDGDGVVLFTGNRKPWRGILLFGPPGTGKSYIAKAVATEADNSTFFSVSSSDLMSKWLGESEKLVKNLFALAREHKPSIIFVDEIDSLCSSRSDTESESARRVKTEFMVQMQGVGMDNDGVLVLGATNIPWILDAAIRRRFEKRIYIPLPEMNARKDMFRLDVGRNNNNLTDHDYKMLAERTEGYSGYDINILVKDALMQPVRRVQSATHFKYVSGPSRKDPSVIVHDLLTPCSPGDRGAMPMSWLDVPGDKLAEPVLTMVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLU0</accession>
    <name>A0A0D8XLU0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="14" type="ORF">DICVIV_10653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716569">
        <property type="protein sequence ID" value="KJH43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XLU0"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF25">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="313" mass="36439" checksum="26A97C7CEA79A599" modified="2015-05-27" version="1">MFHIPSSVWRMLCNQSGLNAGLVLQLACQEQNVDPLVRNRTIDILARHIDDALMYQREHGATKKNIYIFAVIRVGKFYGAYVSTVYIFIKTLHLCNVVLQFVMLNSFLETADYPFFGAHVIYDLLLGREWRDSGKFPRVTLCDFEIRVLGNVHRHTVQCVLVVNMLTEKIFIFLWIWLCVLGLITVMNLLFWLFALASTHCRQRFVSKHLDMESDQIIRFTDRFLRPDGVFLLQMIASHAGNLTCAKVTEALWLIFLRRSGKPMLDEKVESSERGEWESNDDSRKESLPRRESWHEPPLPPPMPQIPIRSHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMG1</accession>
    <name>A0A0D8XMG1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716546">
        <property type="protein sequence ID" value="KJH43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMG1"/>
    <dbReference type="STRING" id="29172.A0A0D8XMG1"/>
    <dbReference type="OrthoDB" id="5778779at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="405" mass="46498" checksum="BEC64A79C4CFDA8C" modified="2015-05-27" version="1">MNNDQLLDDIRRIIAKQTNNELPVLHALPVLPQIGTSSTNKLSTNYIPVTIHIDNQINECDRFDDNERSIKIGRNDEKRKTFNANQYVIPKLEVKDSAVKQVTAYDDDDHFGNLPTTSTGLNCTFVLNKNISISYNNHSIEKLDVMFAEIPTALPTDIVGLQSAVDNLSSNRIKTILNTCRFYDRELRKYLNVPTLVKCFGEVIPSVHSPFSPWRKFLNQLAPKGEFIEYEKILRLVENSKQIENPAETIPDLLNSENIKKAAAMLIPSKRRRTRERCRVQVMMEIKKLLKRYPELNLDRLETATTQKVIQLSEFNMLLEMYGLSTLFQPFYQRLISCFLTYDHKFHYSAFLACLSLIRPSERLPSSNTHRSSQSSLSLPLIKNPNLLFGANLPNKRDRAHGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMM3</accession>
    <name>A0A0D8XMM3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716430">
        <property type="protein sequence ID" value="KJH45054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMM3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8769" checksum="660CC9B81EA277B2" modified="2015-05-27" version="1">MIDYSLYLCILSAIIYINDIQILSECIIYNDDLIHYRLQLFKEVLEVKVYSATFEQFLELYVRNCSRSINDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XND4</accession>
    <name>A0A0D8XND4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716519">
        <property type="protein sequence ID" value="KJH43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XND4"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="11101" checksum="5A1FE5A3F0B477D6" modified="2015-05-27" version="1">MYWRREDGEEGCSNCAFSFCRKCLPYRALLPQLANKPVRVCYQCHEKLNEEALRNQANNGTQITRISIGSTSPQQSPTSNIRSSSKNWWGDGLPHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNF2</accession>
    <name>A0A0D8XNF2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716418">
        <property type="protein sequence ID" value="KJH45257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNF2"/>
    <dbReference type="STRING" id="29172.A0A0D8XNF2"/>
    <dbReference type="OrthoDB" id="5862704at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35711" checksum="E7E44D4389D4B4DC" modified="2015-05-27" version="1">MQMNDSQLIDFVKSNFSTENFEHDGSVAVSLFLRLYSKYCQSINGRDKEVIQKLESTEVLLQQKRPTKVLSDLFALYISCYPLRSNRDWRNVIHWSISHFSDDGMNIFFRSQIGDFLCLTEDSDEIQLFLPTVVKLFCCINCTHVRNEAARVIMSFTEHLNVDQIHRVVSSVQSSDMDGDVVYQVAVKLRPEMSLVDDLSPSKWKRETVRCRIIVKLLLQSSSNCNLSDLLDAVFMSPSANLRLFVDVFEMLDDVVCMHIFHLVLSIYKVIKVRYFDKSVCIFQYFRFYFTFLIISSNDIWNLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNK3</accession>
    <name>A0A0D8XNK3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Linker histone H1 and H5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716365">
        <property type="protein sequence ID" value="KJH46198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNK3"/>
    <dbReference type="STRING" id="29172.A0A0D8XNK3"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="20128" checksum="C5FC9A911FEC38BB" modified="2015-05-27" version="1">MSEAATVPAQKTKKNKPKVEKKSKTTPSHPMYGDMIMTAINEIQDRKGASKQAIAKFIQQKYKLGDNEKKINAHLRMALKKGVIGGKLTQASGTGAAGRFRVAQKSESSNAVKAKMSAKPKLSLSPKKSPAKPKKLTKHKVKLATKSKTPKKSVKAMTPKKPIIKKIAKPKTAKKPTVKKTTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNT0</accession>
    <name>A0A0D8XNT0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNT0"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="19009" checksum="E671C34032A09F86" modified="2015-05-27" version="1">MSAHRYLMPKKKFLKLSQYVGAANKLTEKFSIVPLSSLISNHEVLAAAAVNFVGWEKVESMLPPCLQGRSNNDVILLVADELDCMSKRRINRIIQGEIVPSDSSSSETSGDDSESYDQDFAKSSLRTENMTSMPTNLEDNKKEVGREYFSDTELFEGVGAELDNLPDVNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP45</accession>
    <name>A0A0D8XP45_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="KN716403">
        <property type="protein sequence ID" value="KJH45522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP45"/>
    <dbReference type="STRING" id="29172.A0A0D8XP45"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336078" description="alpha-L-fucosidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="245" mass="28935" checksum="95A491BEE27CC5A9" modified="2015-05-27" version="1">MPTIATILIFHLIAVINAKYQPTWSSLDARPLPQWYDEAKFGIFCHWGVYSVPAFRSEWLWWYWKGDNPDKNVLAYMNSNYKPGTTYADFARDQQTLEYTQNSGIIYQCCITFIKLNSTCVFTAELFDAKEFVDIVTSSGAKYFVFTSKHHEGFTMWPTRTSWNWNSFDVGPKRDIVGELKEAFKVTDVHFGLYYSLFEWFHPMFLNDGKYNTTTYVDVITTFFFKFYKRQLFILTNTRMCLSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XQ45_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716336">
        <property type="protein sequence ID" value="KJH46748.1"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="462" mass="50642" checksum="ADBEE4C20651F8AE" modified="2015-05-27" version="1">MARSTERSVDKNTLKENDDKHQSVTNPTVVDNGRMGKLPMNVGFVAGSEPGHIRESGEEEENNGRTDSARLLEYEDIVGKTVESTSTYNLAKVDNVTTTEPPLQLVQDLIDALAGGGLNAILGPPKKLSESANGVHKKLGDLEKILRKPMKQKQDCASGRMKFLVEELTDLTVKFNYDAAVYSLQHCARVCYETGCTSAAFTRYPRTVCLMRYNNDTQCDYNTTETLTSWRFTGIQQVVKLECIQCDEEVDIHEKKQTDITNLGAFSTDEVNSVIVTNEGVTAKCDGRLEFQILPIGSLPRLNITNDVPARTPADCAKKCFETKDCSMAGFISNPTSTISNGVCLLTSDTNVCGNNADYIPQYAAINPFLISCFRCSACTYHIRTVTPDRELPSFSHTESVSSIGDCAQACYAQRCTMAQYDSSQHLCSMTSEPLNSKCMSETAVVTEGVLPVTLECVTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR39</accession>
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        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716363">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XR39"/>
    <dbReference type="OrthoDB" id="5877983at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="356" mass="37491" checksum="FAAE8F537A18F8B3" modified="2015-05-27" version="1">MRSQPITQQVGMAPSPPLPPPAPPPPTLLVSSSNSVDSFQGKKPTALLADIQKGRKLRKVITNDRSAPQVGGKVSSPSVEGVTISSHLEMETKPVSGSGVRSGGSLTIGSLFVNGLPAKPSENKLHRINKSYTIPTATFTPSTSTEVSFVRPEINSPLTSSLVKPAEFSALSKPSPPPPPIQTMKPAINCNSSGREQFKTLRPMKSESNLPNVNLRRSGSSEDFPSCGSVPSRGPSNRPALHTPSVRPSAPPPPPPSIRINEGKTPEPPPPPAVGPVASTLNNRFGSSSYIINRGEENAPPPPPRTASKATSSALGSSLSYCPKFVNRDAHPLDRFTFKPLSSLPPPPILSQTHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRF8</accession>
    <name>A0A0D8XRF8_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">GDP-fucose pyrophosphorylase domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">DICVIV_07603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716358">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:fucokinase activity"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="78"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="43192" checksum="21534579163804DD" modified="2015-05-27" version="1">MAFLRECGVFTCDSLLVVTDACNDVGSAGSALNALLITGSSSESFPLGAAFKPSLKILEKPWIVPDYPIVHAIRNVNKLATNTNRGVWICGTDALWELDELTNFSFNTTEIAAFYFRGDLQHIETHGVYNLDEQGRIKSINYCCSPYVADSPNIVLGLVYLPPALSTRFLSLHSIYPISRSTYYGIDSGALGLKLYELCLNQLSLFFDVILATCLPEAEFVNNIVITEKSDSDRTLLEQSRREIWKRFHVVKCQAYCLPLIEYEYLGGTEQRIEISKQEIINSLHKNILHRISKMIQNHGGEHSTALLMTLMAINKFYDIKKLSVTTFLKTVHVVVRLCLQNVSQCSHPLMLAAEYLALAAHGKGGLRSGPAANSAFTHIFDQIKTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRS8</accession>
    <name>A0A0D8XRS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
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        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="27051" checksum="403A5D8385287FC6" modified="2015-05-27" version="1">MTLQASYDDDFKSNQQQQMFRSEFFEPSTTSQTPTTNADTPPPGSVTPLHFEEFSLATQLPTLNDYTAAYTAAESMTTAINLTKFQALEPYSAQYFFTTPPDTPPGMLPVTASIVASSLPNLRQSCSTSTSDPTPTIRKLLQQKKKRITAVPCHINSVCSTCQTRTTSLWRRNHLGEIECNACNLYFRKNNCKRPVTLRKDEIMKRKRKPRHNSSHPIDNTTASLDLDVKPNITGCTASLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSD5</accession>
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        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_06471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSD5"/>
    <dbReference type="STRING" id="29172.A0A0D8XSD5"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="300" mass="33516" checksum="670201E02E9454FE" modified="2015-05-27" version="1">MHPIEEENDSFYETNSSAQYAKPNCCTVFGTLLKMCGLCCYIGCPPIPEAIARKLAFHPPKKGVSYTVHCVMNPEKKINEADEIIIFTQPNSSDLGSFLQPRFMNLPQFADIFEMDVYGFDYSGYGYSSGTVSEKNIYSDIRAIYAYVRQTRPDKQIVLLGYSIGTAAVVDLASSHPEGLAGVVLVAPFTSGLRLLGNKPRSEKTHFFDRFNSFDKVEKINVPVLICHGGRDRVVPWEHGVELHEKLKKPVSPLIVHGADHQTILNGAYPQTFCRIHRFLNTQTEVDLSSEETSDDPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSN2</accession>
    <name>A0A0D8XSN2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716298">
        <property type="protein sequence ID" value="KJH47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSN2"/>
    <dbReference type="STRING" id="29172.A0A0D8XSN2"/>
    <dbReference type="OrthoDB" id="5859220at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="4">
        <location>
            <begin position="301"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="427" mass="46680" checksum="CF1A86255F091B25" modified="2015-05-27" version="1">MKYLASIYEEEVNHLRVWQPSAVTESEAERRNTARIQRQNRRSTQGVSKEHLEEASRFAVVENSRRRASNASNSVVSSSNNAFPTRETAVARLASEERESLSLCSDKTSGSTERSSPEAASVGRPNSEQPSSVDHSSDHVNPVLTTATHNATKLCSLSINQTNVAVRRKGQGLSVSRSTRRSTGPVLPEDIHAAVSVRQASENVINTMPSQAHSIEAISSNNKPVASATSIMTSGSNANVFGSKDGGREMILAETSIPNIGSTTLTSSRNAQARLPGNISVNAFSTPTHVLNARPVEMNLNYKALYEKEKLECEKIRKELEEYKRSYNHNCSLSTCTSRLRTVSSSCGPAPIVKSSSGNSVDDGERRAMERRIADLELQLKKLLRTEVSIEPITNGQSETQGGKWGIGARNIEDDNLMSFLFDDPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSZ7</accession>
    <name>A0A0D8XSZ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSZ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XSZ7"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF137">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336042" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="18129" checksum="F054BBBBEE1A5FA3" modified="2015-05-27" version="1">MIYLYIFCLLLLSLLLDVNAQLSEKDYSPLLDQNSASTNPGIYLRIMPTGLAYMREIGMKVVNEQILRLSLPTIRERIENGEVSIYGAHISKYWPPQEYSLDLIEPNMFQWSMSKMHIRAGGEFQASLVNALLPTVPIQGYFEVLLGHVALMISVHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTT9</accession>
    <name>A0A0D8XTT9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716287">
        <property type="protein sequence ID" value="KJH47940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTT9"/>
    <dbReference type="STRING" id="29172.A0A0D8XTT9"/>
    <dbReference type="OrthoDB" id="5848339at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF4">
        <property type="entry name" value="DUF3437 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="1">
        <location>
            <begin position="356"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="50227" checksum="8AF56FE185D6BF21" modified="2015-05-27" version="1">MYGLSFSVRKASMLHQLQVLHRDDTRRYWWLIEELLKGMARTAPTAWHQSVRLLTIVANQWRETETRRRICEIAWRALPKAKIETLRIGISTALKNVCVVLDANMNNDFRGLPKRFHLESVDFWLQRFEGNLGETGSNRSGVVSRQGSEMLIQLDAGIRSSELASKLNMEQISGSSMDLSQVYLRTLLEFFLQYYTDCITCLTPGIIALFPVLLEYANEDDDEIYGSFKDVDIKHSASLLIHEAMSSLQLTPKFADPFLDVVVQSFYTAYLWRVKVSVLKFIQVLVFSNIYEMEKDSRPTKVVRLLYDAIIDHQMEVRREASRAMLTLILCGYVNVSDNLSDYLNKMMKNKNISILHGAILGMGAVVRAHPFSTPPAIKPMLRALCGVTSHNAELQKAATTALREFRRSHRDNWEKMDKILGSDLVYKIENAIAPVYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUP5</accession>
    <name>A0A0D8XUP5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716369">
        <property type="protein sequence ID" value="KJH46106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUP5"/>
    <dbReference type="OrthoDB" id="5827301at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="29537" checksum="A5B5828FE5081BB8" modified="2015-05-27" version="1">MLSNPAIYKVNSKKARPVRPPPNMLDHDMKWIQFYGLLAPTLTTLHNLYSQLDTSVQSLDSAIATFSETQLLAPTLTTLHNLYSQLDTSVQSLDSAIATFSETQLRPCVECFRELCRLHSIGIFASLRRAQLDRMANFREIPEEKLRLATTYYTSMLYTMGILASRLQGFRFEWQCKFPYSMSDPMRNLLDLVYLTVDQLVADCLFAAEPATNAILVTNNLFPFNCDSLANAVVFKQFDVQIILVALYFSTWNVKIVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUT2</accession>
    <name>A0A0D8XUT2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_06299</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716300">
        <property type="protein sequence ID" value="KJH47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUT2"/>
    <dbReference type="STRING" id="29172.A0A0D8XUT2"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF267">
        <property type="entry name" value="DEGENERIN MEC-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16411" checksum="26F0141BB4EB617F" modified="2015-05-27" version="1">MEKTIYDYYLNIFGSYIRLPSCNETKDDYVVPNVLPCEIRHAISSVANRTAPAPQRIRPEHLKILPPVLIKTLARLFTRHPFELKVLKVSREYKKPLCLVFIGLRKAFDSIETEAVTEELTNQALPAPYIEILCNYQNHLVL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
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        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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        <source>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38554" checksum="21ADAC0F447EBEAF" modified="2015-05-27" version="1">MIEKRKNLEAITFSFFVGAVDHGSIMSGSKKLPVNLISVLPDIPYKKTDATFRVNKENEIDIAENMMIMSISPSAAANCSELIMGDRITKLNGNPVKTKTEAIATLKASLGNEIKAEVLRRQYTSPLTPERAKKIGLNRLDGFAYFLLSCSKENNDPVSSFGFTLKLLKNRAHVIALDPKGVASNFFCIGDALLDLDGTPIPFNDLEFVRGYTQKFNKNNKFTVVIERPISKEALFMYNMLFKLMLPQESDVEMGQDAVLIGKEAANMHRMVFRRLKPKSVYGPKAEKRVEPTVRTVDVSDKAKNIRVASSAMELKIASDIDDEDELKPVDRKSHAKDSSMFDDF</sequence>
</entry>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="629"/>
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            <dbReference type="Pfam" id="PF15249"/>
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            <dbReference type="EMBL" id="KJH48429.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXH1</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="210" mass="24210" checksum="4B2B2207A7525BD6" modified="2015-05-27" version="1">MLTKLRSPKFSFSWLVNLAHDNTSNLYEADYDLYEFFLENRNALNNSFVFVLGDHGPRLGREAETAYGNRELNNPFLYVVVPEQLRKKQLYKQLRQNSEQLVTPHDLHSTLKDILYFQPSTSFSDTSFMKYDSNPRGSSLLRKFEDGVRRTCKTLPIPFHHCICQFKTDTISDSNLTTTLGLFAVKHLNGILESHGVSDKCQKIEPGKVR</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="202" mass="23139" checksum="F88196E28C2E9096" modified="2015-05-27" version="1">MISNNKRFNRNDIIQAQSDEDTTRALVIRSSETAEGPSRSSRSSNSSPEAVEFVSHDLSPSSDSANAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALALRLDLLESRVQVWFQNRRAKWRKKENIKNGSHSERDSFSEDGRHSNKTNDCGAFSINNLLAASRVPRGRRPNAKYPRVQVQSLNLKFYRTANEPKLIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXY1</accession>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23599" checksum="371CB00B4A96898E" modified="2015-05-27" version="1">MIVERIIAMFNVGRYEHSTKKMGNCLIALAILISVGQSVWGYRNAEFNEPHITCLEVPTNRSSQITVLNILMIFVHFIAVLIITFIYFVHRRHIRSAQSLTTRFQFSENLTSSRLLITLSFMQFALFITYSIARMCLAKKVLINLTESAVYRSNILALYLVSEYTLLLPLITMLFLRRAKQARQSDIRSMIQLAAHTEFAATKEK</sequence>
</entry>
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    <accession>A0A0D8XY24</accession>
    <name>A0A0D8XY24_DICVI</name>
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            <fullName evidence="3">Lactate/malate dehydrogenase N-terminal domain-containing protein</fullName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716236">
        <property type="protein sequence ID" value="KJH49395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7273" checksum="8475143F3A370F60" modified="2015-05-27" version="1">MATTVQEVFEEIAPVAPTAHGKVTVVGVGQVGMACAYSILQQNMNVIALWFITTDKDQSSDSDICLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY52</accession>
    <name>A0A0D8XY52_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05136</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716257">
        <property type="protein sequence ID" value="KJH48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5843478at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13547" checksum="183AC461E6A81221" modified="2015-05-27" version="1">MIDTSLNDTEKLQKIVNLSSSYIDEEPHSRVLLEKLVLLKSWLDNRLQNVGKRMRSIHEKKFKLLFVLKGSPYYRRLVYKAEQMEEEQIEKEFHEKAEELGINETIELIQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYC0</accession>
    <name>A0A0D8XYC0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716311">
        <property type="protein sequence ID" value="KJH47351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYC0"/>
    <dbReference type="STRING" id="29172.A0A0D8XYC0"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="361" mass="41891" checksum="F6C66935C5055589" modified="2015-05-27" version="1">MLYNNDFELPELGTTVSFKGHTWDVLKKIYEGIFSHVYMLRDVMDHRKLYAMKVEKQFNCERPVLKLDVAVLSQLKNTIGFPTLIIAGRTDTFKFCVMRLVGPDIRSLMWEMPNRRFSPSTSYRIAMQTLDRLEKLHEIGYINRDVKSQNFAIGLGNQSSIIFMLDFGLTRRFRNQDGTLVKRRVSGPCVGTYPFAPLASATMRDQAPKDDLEGWFYMMMEIFTGYLPWHNNQLILDHSLTREWKQYVRGAYKTTMLESLPYEFTPIFNNIISMRFEEQPRYHFIRRMVGASVSRQGINLALPYDWQVEPSLLSLIKKTTEYTTVPAPVILNALGSYQDMTAVEVIPYLEPNQIIPISTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYM7</accession>
    <name>A0A0D8XYM7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_transf_20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYM7"/>
    <dbReference type="STRING" id="29172.A0A0D8XYM7"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF110">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16970" checksum="61D9632904BFAF2C" modified="2015-05-27" version="1">MSLLGVLNNYNRGNYKLNPVVVQEQDYNVYYGGISNGLLWPALHNLPEYIVSDYDTPKDFIWIHDYHLMLTGMVMQSLDPNLENFSVLIEMLKDKKCLFLLRLVFSFISRSNRQAISSRSMSLVVYQCYEDCYDSPKFVKKISLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZQ2</accession>
    <name>A0A0D8XZQ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZQ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XZQ2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="145" mass="16594" checksum="0D09E7499A2FC4E8" modified="2015-05-27" version="1" fragment="single">MFSSTDTKRTSPYDYLFKLLIIGDSSVGKSSLLLRFTDNNFNESYAPTIGVDYKVRTMVVDDKTIKLQIWDTAGQERFRTIASSYYRGVQGILIVYDITNENTFQNIPHWLKNVERFGCENVAKLLIGNKCDMESRRAVSTEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZS3</accession>
    <name>A0A0D8XZS3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716237">
        <property type="protein sequence ID" value="KJH49377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZS3"/>
    <dbReference type="OrthoDB" id="5822308at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17805" checksum="0F772BEB12416639" modified="2015-05-27" version="1">MTGLVVIKFIVGYVMLWCLLLMRLPLPPYTIYICLVGFGVCICTVIGIVVKNSTLLLPLYVYIIASIFFLFFLGGYYFYVNIFHKEKVLDAFGENFDRYSWIAHLLNVLLLLFHYWQLGVISKCRRYYNYSRVEKQPFELPLRSETKEEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y024</accession>
    <name>A0A0D8Y024_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_04366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y024"/>
    <dbReference type="STRING" id="29172.A0A0D8Y024"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF112">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="71"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH49487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="364" mass="42032" checksum="3AE0F6D31DD6624D" modified="2015-05-27" version="1">MGFRPEDAIQTFGSKLLPYEQSEIFNYVRVFFVGSQAKKRGGVIGGPNNCGYDDENGSYQLVAHDHIAYRYEILKVIGKGSFGQVIKAYDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDVDGSHNIIHMLDYFNFRNHKCITFELLNINLYELIKKNKFQGFSLMLVRKFAYSMLLCLDLLQRNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGSKYSMPIDMWSLGCILAELLTGYPLLPGEDENDQGDELFIDFLKRCLDWDAETRMTPAQALKHQWLRRRLPCPPLRDESTAEPEGVAPSLMTGPTNALRTVSSTNTSSFTPQKLAHVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0U7</accession>
    <name>A0A0D8Y0U7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0U7"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20355" checksum="800978AEBB166627" modified="2015-05-27" version="1">MSSRGIELLHEVLSSRNAPSEDQAQRLAEKLFSILTGEERWTDELCPHKVAESVWTVFTDGARLNWSADTLREKLNSSHPFSTAVVERKVDMLRSQLNTIGWDYPELIDCECTLLNTVQTELLNRVSEPFVSLKLHTLSAGETKSKRIEIHLDANQFQDLHWKVKEAENIIKQLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y196</accession>
    <name>A0A0D8Y196_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MEIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="486" mass="53005" checksum="E3931BC0B3BA7CE4" modified="2015-05-27" version="1">MSEPQLWPSAMDMWQFHAPLAPGTFPVAAQTHPIGDSSSSIIKLEKADPIEYGDGYGPPAPPGDVSYPVPTDPSGNMAPYYNNMYPLGGPMSTSEQMMHPHLDEQVKRDKAAIHSLPTFSFRHPLFPLLTVLFEKCELATSTPRDQNRDGTSSNDVCSSNSFKEDLAEFAKTVHELCDNFCNRYVTCLKGKMPMDIVGDERASSSQPPLSPGSTAQSASPSMGTPMSHFQPPYEPQTVPLPENNRAMTNSMEGPSMNYSLASQPGHPLAMGGTSPSAAGTSQTLPMQVVNSPSSSTCLLNDVTSQSVSDTSIQPNNNGNPPSLDSISEAELCMSTAGSGGSSDPMDECLLHSGMLMDCTGYAGTSEQHPLYEMYEYCQQVAVYPQHPSDPPQAERDAPIRSSKSAQVQAKKRGIFPKPATNILRAWLFQHLTVIASSNSFYSRFCLYPVLSRRRRCRGRDTWPRLTYVLYSFSVCICVHFSTAKKV</sequence>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716204">
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            <dbReference type="EMBL" id="KJH50495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="31" mass="3717" checksum="839350BFD9E2D8EB" modified="2015-05-27" version="1">MEYTSIVCLYANHVQKKKSMKVLYLMPHDFV</sequence>
</entry>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
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        <property type="match status" value="5"/>
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    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336393" evidence="5">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="437"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="585" mass="65563" checksum="67E2F6D2046A93D8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y392</accession>
    <name>A0A0D8Y392_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_03339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y392"/>
    <dbReference type="STRING" id="29172.A0A0D8Y392"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="13">
        <location>
            <begin position="208"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH50489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="838" mass="93539" checksum="11051FBCB67582B8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4G5</accession>
    <name>A0A0D8Y4G5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Small ribosomal subunit protein mS23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_02754</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="21">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="4"/>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4G5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4G5"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
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            <position position="841"/>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="81" mass="9181" checksum="DDD340F9C9E4BD41" modified="2015-05-27" version="1">MLRYACRLNDLCLPQHRNYNKTNPHVATSHNNVLYESANSSNSTDSTRSIVSNRQRTTKEVERDNESCSDADGLDVPKELV</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="111" mass="12464" checksum="6B903752F5522AD1" modified="2015-05-27" version="1">MGKPKGIRTARKLKIHRQSQRWCDKAYKKAHLAIRKCVRVQLIKNGKKITAFVPNDGCLNFVEENDEVLVSGFGRSGHAVGDIPGVRFKIVEVANTSFSALFKGKKERPRS</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y623"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336493" description="7TM GPCR serpentine receptor class x (Srx) domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16505" checksum="BFFF5E44801ADF82" modified="2015-05-27" version="1">MGGYVCIWIYTLLQCLVFYESVSFMELKQIIVVASPNSAVTALPHSPPHSITPELPVNIKNRTTKARSAFTNRTFLAGLYKPVNKVEFIIGVVTFLIGTTVNTIVLAVLAILVRKLRTIRKKKTSSPSTTATTGTTGTTGTTGTTGNTGATGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6P3</accession>
    <name>A0A0D8Y6P3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beige/BEACH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716211">
        <property type="protein sequence ID" value="KJH50236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6P3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6P3"/>
    <dbReference type="OrthoDB" id="5848946at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="186"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="874" mass="100279" checksum="703832BECB3C2F4D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y714</accession>
    <name>A0A0D8Y714_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="4"/>
    <dbReference type="EMBL" id="KN716207">
        <property type="protein sequence ID" value="KJH50371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y714"/>
    <dbReference type="STRING" id="29172.A0A0D8Y714"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF18">
        <property type="entry name" value="PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="483" mass="55987" checksum="507CE7CCDBEF728F" modified="2015-05-27" version="1">MSQGMRHADAVIYGEYDNGRRMKENELKGEHIKNYRTTYDENSFNNTMAVEVRRDLFKTFWDRYSDKPDTNSMMLNHTANDLDASDRADILSSLPHLGNKDVVDIGAGIGRFTTVLANTARWVHSTDFIESFIAKNQERNAHLGNISYQIGDAVNLQMNERSVDLVFTNWLMMYLSDHEVIEFLFNAMRWLRPDGYLHLRESCSEPSTACSKTATMHSSAEANPTHYRFSSLYIKLLRTIRYRDNSGKLWKFDVQWSCSVPTYIQRSNNWRQVHWLTRKVPANNGDTDTSISLLLNLFSQIWPAEQVEWDLKLNIESYVWTDRVFSNAINDEVVPRNGTALVFTPRKRSPYLHVNSHLLAEKFTCNVWTVETNEYYYRTSLTKANHEKNHRVRFGWNESLTSSIDYWSQRDASFDCLISTELLSTNSDDEIKRITRMIGCGFKHVNILDVTNDSRTAEVMFYSEHSINAEPLGCTFLLISATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7R7</accession>
    <name>A0A0D8Y7R7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRO1-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7R7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7R7"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09240">
        <property type="entry name" value="BRO1_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000001">
        <property type="entry name" value="programmed cell death 6-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <location>
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            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH50646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="871" mass="97165" checksum="F2E604B65AF92C08" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336321" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="78" mass="9102" checksum="56D42B339A9D5429" modified="2015-05-27" version="1">MHFWHRVLLVCCFVMLLLANDQQPDKKPAFLSRYGRAVLSRYGKRSPRVVSPDNELVLCRNVNGEFECKPYNDDDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11359" checksum="D25EA0AA76F4226B" modified="2015-05-27" version="1">MYRSRKTNARIDSELKAYSLMPNCPSCQKPVYFGERVSSLGKDWHRPCLRCANESCKKTLTSGSHAEHEGKPYCNRCYGALFGPKGYGHGGTESHTFHGGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y927</accession>
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        <submittedName>
            <fullName evidence="4">FERM central domain protein</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH53338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y927"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="FERM_N"/>
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        <property type="entry name" value="FERM_PH-like_C"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    </dbReference>
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        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="573"/>
            <end position="592"/>
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    </feature>
    <feature type="domain" description="FERM" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="440"/>
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            <end position="453"/>
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        <location>
            <begin position="460"/>
            <end position="471"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="630" mass="72508" checksum="13D1A306FDB54C5A" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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            <end position="224"/>
        </location>
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            <begin position="318"/>
            <end position="510"/>
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            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH53315.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    <sequence length="400" mass="43176" checksum="435CC0FE23B16DE4" modified="2015-05-27" version="1">MQYAVRYQIDSLGLESINEGDVILSNHPRAGGSHLPDLTVITPVFFKNIAGPVFFLANRGHHADIGGIAPGSMPPHANFLEEEGATFVSFKVVNKGSFQEDLLLEYMNQPGSVPGRLQGISLVCDLINEYGFDVVQAYMRHIQSTAEESVREMLKEVGSNIYQRSGSTRLQACDSMDDGTEIQLSITIDVEKQFILTLSHVVKISIPDGTLLSPSELAAVVGGNVLTSQRICDVILKAFEAVAASQGCMNNLTFGDDSMGYYETIAGGAGAGDGFNGRSAIHTHMTNTRITDPEILESRYPVILREFSVRENSGGKGKWRGGDGVIRSLQFRRPLCLSLLTERRVFAPYGLNGGQNGARGLNILKRQSRVANLGGKISINIETADILTVMTPGGGGYGAY</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="175" mass="20230" checksum="99352E7CB74B435F" modified="2015-05-27" version="1">MLNDFITIVLKLSITRILQLMEDTTSGWFTIDNGTMLVWEGVCMLKLDKVIYLFKIRNEGIFSIKIPIANVKKVSSDGYWDCAEILGCFGKAGATFYYHADCIKSARQMLMVLIIYDDLYVFTDEVTFYLISTILTCPKKYQLLFARTIYSCLLEFGSKPINRYRERKILSGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9H4</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="163"/>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="35212" checksum="260CDFE8C247CB32" modified="2015-05-27" version="1">MSLCSFHNIIRCPHTFITSLPKASIIVCYFNESPSVLIRMVNSILDRTPLELIYEILLIDDSSEWPDATLQAADYQRKHPKWNMVKFLKTSSNQGLIRAKVFGARKARGEVLVFLDSHCEVNQDWLQPLLERIKEKPERVVCPIIDIIDLDTMKYVESPVCKGGLNWGLTFKWDYPPHSYFLDPLNYVRPLKSATMAGGLFAIDRSYFFKIGAYDEGMEVWGAENVEISFRPEFFKARPYLTSRSDYGDISNRLELRKKLQCKPFKWYLENIYPELLPNNIPQNTDIIQKPFVYGKKYQAGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAW5</accession>
    <name>A0A0D8YAW5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAW5"/>
    <dbReference type="STRING" id="29172.A0A0D8YAW5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="249" mass="29154" checksum="466E0676D72DF89F" modified="2015-05-27" version="1">MSLRQKSEVLYQVCAGMRFLELNGLCHRHLRASNIIIHHSTNHMYAVKITDYMLSYHFLHKDAVESVNMNILDWPWWAPECIRKRVFNIRTDVWAFGCVIFELNHDGLGPYAFNEPLPRTCDDLKAIFDKGGKMALAEDDIETFLDQLFYKCTDYDPASRPSFDFMFQFFRELLFDFAVGPGPALQKYMKNPEEKPKEARKESGRSSRKSSRKSSRKSSRKSSRKSYKKSVKKLSKRLSKKSSRRSIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB89</accession>
    <name>A0A0D8YB89_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor Tu domain 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB89"/>
    <dbReference type="STRING" id="29172.A0A0D8YB89"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Selenocysteine-specific elongation factor 3rd" evidence="2">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Selenocysteine-specific elongation factor C-terminal RIFT" evidence="1">
        <location>
            <begin position="152"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28823" checksum="140B5FA71627F521" modified="2015-05-27" version="1">MTGTVIDGTIRLNQEIVIPILKEKKKVKGLESWKQTVEQVSVGERAAILVQQLSADSISRTMIGSSGALTEMKSCIASTKPITFYRGTISSGMKVHISTGFDTVMAECQFLRPDEEQYEQLTSLEVPCVYHQGRGCRFLFHGHLGDSLNDRKIRRFVRRQRSGQVERVESAKSIVCNSLFKKETNISMFESLPVCLSTGETGRVVCAFGKAGKARIEMTTPLSESTLKMIAGGESVQVTIYLKKYIGRKKIEGYLPGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBH9</accession>
    <name>A0A0D8YBH9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal recognition particle 9 kDa protein</fullName>
            <shortName evidence="9">SRP9</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SRP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBH9"/>
    <dbReference type="STRING" id="29172.A0A0D8YBH9"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000001">
        <property type="entry name" value="Signal recognition particle 9 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008832">
        <property type="entry name" value="SRP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017029">
        <property type="entry name" value="Signal_recog_particle_SRP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP9" evidence="10">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="9061" checksum="C05ABCEA858AAA10" modified="2015-05-27" version="1">MTYFTNWDEFVKAVEKLHSMKPESCRFVTKYNHRDGKLSMKMTDDVVCVQFSTNQLQDVKRLEKLSASLMRSMVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBR9</accession>
    <name>A0A0D8YBR9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBR9"/>
    <dbReference type="STRING" id="29172.A0A0D8YBR9"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="38365" checksum="8EC0021EFF90EA4C" modified="2015-05-27" version="1">MLSELLSGVICASLCDVVRLEAICRLARNRHVFTICTELEVVCRIKSIDHKNQSTFIVRKQRPGYRASDALSHRLCNEIIIRPSVMQVAASSSAPEMIKVEKVGAKKNVALITLNRPKAFNALCNQLMNELSSSLRSLDADDAIGAIVLTGNQKAFAAGADIKEMVGRDFAQNYRGRFLDDWDTVSKTSKPVIAAVNGYALGGGCELAMMCDIIYAGDKAQFGQPEINIGTIPGAGGTQRWARAAGKSMTMEVCLTGNRVSATEAKDCGLVSKVFPAEEVVNEAIKLAEKIAEQSPLIVPMVKEAVNAAFETTLQEGLRFERRLFYATFATNDRKEGMSAFTEKRSPKWTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCB6</accession>
    <name>A0A0D8YCB6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Helix-loop-helix DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCB6"/>
    <dbReference type="STRING" id="29172.A0A0D8YCB6"/>
    <dbReference type="OrthoDB" id="9978016at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19697">
        <property type="entry name" value="bHLH-PAS_NPAS4_PASD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000081">
        <property type="entry name" value="Dysfusion, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056192">
        <property type="entry name" value="bHLH_NPAS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF39">
        <property type="entry name" value="DYSFUSION, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23183">
        <property type="entry name" value="bHLH_NPAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="66561" checksum="F453C72DC03D830F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCF7</accession>
    <name>A0A0D8YCF7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron-sulfur cluster assembly enzyme ISCU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NifU-like N-terminal domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NifU-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCF7"/>
    <dbReference type="STRING" id="29172.A0A0D8YCF7"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="17972" checksum="C9CF2063EC8F7ECC" modified="2015-05-27" version="1">MISSNLRVATNLCRVAVVRQANYHEKVIDHYENPRNVGSLDKNDPSVGTGVVGAPACGDVMKLQIKACDYEAFLVDENGKIIDAKFKTFGCGSAIASSSLATEWIHGKTVEYAANIKNDQIAKELCLPPVKLHCSMLAQDAIQAALNDYKKKQINRKTSSKCVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEJ7</accession>
    <name>A0A0D8YEJ7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tectonic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEJ7"/>
    <dbReference type="OrthoDB" id="5779933at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336584" description="Tectonic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23764" checksum="AFCD5742BF5E7C6E" modified="2015-05-27" version="1">MRFFHVIYLYLIFIVVTVQSCSSGTSFARESEIITDPAFTFTVSPPVRWTYYPRIGNTGLVTLTNFFPGQSVTSAEALQYAQNDVNAAFLEALNEVPIATVGITTSVSYSPDEISNCYIGQTIPGGTRIGYLAGGAVTQISLVSGVSATAVSCPLPINQIQTGIGPYEDYTKVVTVSTRGGTTLSRYTWIRILSQFQSILNYRYQALFRSKITMENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEK1</accession>
    <name>A0A0D8YEK1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEK1"/>
    <dbReference type="STRING" id="29172.A0A0D8YEK1"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="11102" checksum="BA41381074688C66" modified="2015-05-27" version="1">METGSVKGFCYFIYFSILFQTYLLGDQSNRSLFPQPKLKEVDYRASCACHHELVSSGWVCSVCLSVMCQFMPMCKTCGAIFKVNALPRKAQKRKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFT1</accession>
    <name>A0A0D8YFT1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFT1"/>
    <dbReference type="OrthoDB" id="5849338at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="100" mass="10451" checksum="47E407B865A7B6C4" modified="2015-05-27" version="1" fragment="single">AAELAEALYSRTQAEQLSSYASVYSAGFDTSSEYVNRTHTSPRSLPYGANQSLSTAVYPSGYPAVSASPAANFLNAQTGFAPFGSVNPFSATLQSSTRLA</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17712" checksum="26ADE5128EC9B173" modified="2015-05-27" version="1" fragment="single">MEKIIYDYYSNLFGSHVRLPLCNERKDDYVVSNVLPSEIRHAISSARNRTAPGPDRIRPEHLKNLPPVIIKTLARLFTRYLSDCKVPKVSREYKTPLYLTFIDLKKAFDSVETEAVMEALTNQALPTPYIKILRELYKNFYTKITSFYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X614</accession>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH39980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="39234" checksum="744F51B35B1E2A2A" modified="2015-05-27" version="1">MECTIFSFSHQLQRECKFPSHIEGMHVRDDDDVDRCKTDSNASRRSLYVRHNGAKRFTPGDPCVVCGDAASGIHYAVAACNGCKTFFRRVVLENRTYSCKNNGDCIIDKNMRCSCRHCRFKKCIRVGMDRSELNVERRRKRKARRDADHNDCPSEVEITDPLIELLIDKEAKCIFFLDTYASNPMPVGMSTNFSYWRAKILSVLVEWAKSFEMFNRLALDDQMRLIVHSSFSNLVLAEAFNTPEKYTDRIVFPDGLSGFRSPSANTLKERSGLIPTVVAVINNILVPIRQCLSLSETAQQLVSAKRRRLLDSLRRHLDAKLKNPTESAARFAEILLRIGNVQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X631</accession>
    <name>A0A0D8X631_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718970">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X631"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
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        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF0">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335590" evidence="1">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20382" checksum="78D488563C9634E8" modified="2015-05-27" version="1">MINILLCTIVLGKSMAAIMDPSCTIPVAGTLMFSPEAVNCQNKISNDNCKKFYPKDVDISMPDDREEACWKKQGGNGVDQQMVQVAVASCPRTCGYCCLTPEYNCKNKQDSRIPCSLITMSVCSDPAWRTILVEDCPKTCGLCNWNQICNSDRVDCVDEMNNQSASLRKEVHLSKNNTFLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8N3</accession>
    <name>A0A0D8X8N3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717791">
        <property type="protein sequence ID" value="KJH40132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8N3"/>
    <dbReference type="OrthoDB" id="5865309at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13380" checksum="BDFF4C6BB0C54E49" modified="2015-05-27" version="1">MSWPDNQYYETDWTSDDESSDELEFTVSSAASSAIKYAMYGNIPASYQKATTVEGIQQPCMYRIGRWIYRTEEKLNDLSIMNEVFSRIISDCRDDFPYYIQIHEREDIFDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8T7</accession>
    <name>A0A0D8X8T7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_14037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="KN718300">
        <property type="protein sequence ID" value="KJH40049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X8T7"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF44">
        <property type="entry name" value="RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="5">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="30511" checksum="7FC4613A3DD86B0F" modified="2015-05-27" version="1" fragment="single">IKIFKVTLNIKGGEEKSRLDTYIAEKCNISHSKAQRSIQDEQVKLFGIPVTNNDHLVKLDEDIMVLHKQSGVTVHPGAGTSNNTLLNAIIAYLGKIPYTCVRPGVVHRLDKDTSGLMVIAKNEEAHSFLSGLLSNRNIRREYLAVVWGMLSSNPAAIKTNIAPKRGNEEMMCVAKTAGKLAITNYSVQKVVGQMNLVKCVLETGRTHEIRVHMSHMGHSIVGDQVYGKNSSKSARYAKNSDFICNFNRQALHAYKLGLYHPKEKEYMDFCSDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8V0</accession>
    <name>A0A0D8X8V0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717650">
        <property type="protein sequence ID" value="KJH40172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8V0"/>
    <dbReference type="OrthoDB" id="5849517at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="12931" checksum="559C8F4FB0D67602" modified="2015-05-27" version="1">MKNDIHSDIPDCTGRNMTMMLRGFSVDAHNILRSRTAKGLIPTVEHKPLPKAANMYKMDYSCSLELAADSLVNKCLRYQKSPTFDDNGWNFRDIDANTVNTPLEALREVSNHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8X7</accession>
    <name>A0A0D8X8X7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716924">
        <property type="protein sequence ID" value="KJH41040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8X7"/>
    <dbReference type="STRING" id="29172.A0A0D8X8X7"/>
    <dbReference type="OrthoDB" id="7754674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012090889" evidence="4">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="35328" checksum="2EC03266D84BF9F7" modified="2015-05-27" version="1">MLVLIILVIVPSVLTDNITREENCELKKHCGAHFLEKPLRYARSLGGTRAKQNEFPWMAAFYVRKVKPTQPFTFTTMACSGVQISKLHVLTAAHCVVENSPYLQMYCSQRIPVRNTDKYTVQDPVFFSMFIGSGCTNPDLCQRNRTNYSVAQVTVHEDYNPCNLSNDLAVIELDRKILPVHGSAICMTNPGELIRYPPYAVGFGIDPTDRPKRKEILSNLRFVKLAELGAGDPRLITAGDYTKSICKGDSGGPLTRKRNGKNYTLTGIAIASDPLCDQPKTDVDTNSSGTGFTGIFTKNFPRRKLLPENSLRRPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X944</accession>
    <name>A0A0D8X944_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_12920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="KN716903">
        <property type="protein sequence ID" value="KJH41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X944"/>
    <dbReference type="STRING" id="29172.A0A0D8X944"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF27">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH41110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="10">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="15534" checksum="E556676A46664A56" modified="2015-05-27" version="1">MVGVDGKPAVGSVLLSGCSTTELSNQCCSTSDVVSRQSTFANPDDNSTYSSKLSLATSNTSKRSLLHSSFASKIKDNVGRDRDRSRSDELQERNAMLPPAMRCAYATEVTTYNSPSGNENIVKHGNQSKKKKHGMKVAKCTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9X9</accession>
    <name>A0A0D8X9X9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminoacyl-tRNA synthetase class Ia domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717105">
        <property type="protein sequence ID" value="KJH40572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9X9"/>
    <dbReference type="STRING" id="29172.A0A0D8X9X9"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="6">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="429" mass="47541" checksum="4F96AD230C2D9774" modified="2015-05-27" version="1" fragment="single">GESNISEISGEAHISKQLVEHVADLIEEKGADVWWTYSVEELILKSLSLQSVSDLSKGNDIMDVWMDSGVAWYCARKAFHDANTSFPTDAVVEGVDQFRGWFQSSLLTSVAVQDSIPFKKIRVHGFCVDDNNKKMSKSLGNIVDPETITDGSLRQKALGADGLRLWVALHAGESLGESKIGEKVLADIELKLVSIRNSMRFLLGGCHGYMGQCPKYIIPILDQRFKAILVDVTAISTVWNAMFGKLQKLPLSYRSSRCSSLLSTHAERPLYCESLIRDRLYCARLDSNDHLSAQFTLHSAGSTLAECLSPLLPHLSIEFFQHQPASTKKQKVLCLRSTLAAEAGPSCDLFKSGALVGVTPSTKALLMHCQMEETSFDSQLCELFGVSMVRIQDSDVDFIHPIKSDRLFCDRCLQFNVDVSPKDSLLYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAP1</accession>
    <name>A0A0D8XAP1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716783">
        <property type="protein sequence ID" value="KJH41653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAP1"/>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF14">
        <property type="entry name" value="DEMENTIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="23344" checksum="48051020C7055B44" modified="2015-05-27" version="1">MPLSPSSSLALPDETSEFSPQLLEDLRGFRYLLTKMGDQIIRIESRLDSELAYMTRALEEERGKYLSLETTMNETIELHQAEFQALKQEQKGIANRLDYQYNDRFKRVEESVESVENHMVRMENSIKDTLDIRLSGPAWGNAVFLSSANIVVEFLKIVLYLVATILDVFLPFFGSRNKAGVFLCCVIAVAIMWQNLHIYRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBK4</accession>
    <name>A0A0D8XBK4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ/DHR/GLGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716731">
        <property type="protein sequence ID" value="KJH41963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XBK4"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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                <person name="Hallsworth Pepin K."/>
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</entry>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8753" checksum="B7DD64A396B58427" modified="2015-05-27" version="1">MKGKIRRETDKIGKSPSDLTSARIEPVCKKRMCEGSFTHYEDRMDCSVPPFTYPVKPSQMQIHIRRSHAVLRENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCX3</accession>
    <name>A0A0D8XCX3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_12512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716809">
        <property type="protein sequence ID" value="KJH41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCX3"/>
    <dbReference type="STRING" id="29172.A0A0D8XCX3"/>
    <dbReference type="OrthoDB" id="10260567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 35-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="10">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="10">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="9">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="33741" checksum="FA4730C06015D249" modified="2015-05-27" version="1">MQERFSNIEILQIYARILLPLHMHENNLDKTDIAISELLEEDRNLSLEDSLMIDRTWTASLAYHFIMMAQRQLFDGKILFSLQFGTDGDHNGAMKTSVYLTQFEEYIDPVEIYSLLEILKKKRFNERVVIGFRQPIILAIKKKTPPIYLSNVKTANCCFTDMEKALSSCACREFNLCSRAFMSLESLTDPSSEERKAYQKLALDLFSRQPPTDNHPKLVRCSACDKPLADYEFCCPHCETIFPACIASGRPIITHQFWLCPICKQRAYEEEIYHYKYCPLCHSQIMWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCY8</accession>
    <name>A0A0D8XCY8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716784">
        <property type="protein sequence ID" value="KJH41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCY8"/>
    <dbReference type="STRING" id="29172.A0A0D8XCY8"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="308" mass="34784" checksum="F96BA0E35B2956E8" modified="2015-05-27" version="1">MTADVVTQPPITTSESRRFTSIRSVLGEWKQLFDGCNFIKKKERSRSRRRDVKDAKAKRVVSASVAQRSTRKSQSTELCVCDSIDDQVIEKFTALPPGIDQREWLATHTLALFDHVNALCGSLSEFCTPVVCQYMSYPGTTKAYYIDERGKRHLYSAMQYMDCVMSFCEKASRCEEMFPTKYGNQFSGDFDSQIRRVVRLLWHCCGHLASKHWDDLGQLELRPQCSLVMAHLAKLSKTFALLDIKDQQLINNLVQAIRPLNMISSSHGHDTSGGTSQRWSRIPSSKSGSWGGHPTPSAFSCKSYAQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD35</accession>
    <name>A0A0D8XD35_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716796">
        <property type="protein sequence ID" value="KJH41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD35"/>
    <dbReference type="STRING" id="29172.A0A0D8XD35"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF4">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="350" mass="40669" checksum="63D9B2C13F214475" modified="2015-05-27" version="1">MNGTWPELNYNITTEKPFIDRVFSNTSLAHRLLERFSNGLSNDEIDSVSAWWLVFIVVEFVILTISGHQERFALNDSITSICAGILSQCFKFGGRTVAIFLYVFIWNNFRVIELPWDSPYTWILCLFFQDLMYYFGHRAVHEAGFFWGLHTIHHSSEYYNLSTALRQAAIQDAGLAIYDVLQAFFIPPTIFLVHRYFSEILQFIMHTSLVGNLGPLGIVFNTPSHHRVHHGRNPYCIDKNYGGVFIIWDKRNFLNDIGFSKYLLFFMSDILPTSLARMMFGTFEAERLDDPPVYGLVHNENTFNQIYLQVHVLWDMLYFKGQMKNEKGEPLFPGIVNKVANNIFFMNSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XDC3_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716644">
        <property type="protein sequence ID" value="KJH42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDC3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDC3"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="38161" checksum="F715B8256011EC94" modified="2015-05-27" version="1">MELHHKITFTSFGHRHNNDLLHVTEQSGGHTEGLLKLWKVQYFVFKDFAIAKYHIALNIGKGPLSDLVFNPASVLQEVVASGTPCPSPLVLPEKWNDQVMLTQRNLQASRILLSSVCAHASTLDDLWYFCLLTCQHIAWLLAMRPSSVGTFLCERSEIDQQSKCGNVISSAALAEIPTLAALFDKIPCVSVSLTDGSLLMALNALTRLSDENIAVAATGRECSLFPVAMLLRFCSLNLHRQQICGHTTPFLRDWAAVALSSMIKQAFKTKTSISEMEHQFQTLNTLQLMCSIHQSDVQRRQLDCLMTLLQTDGSQLKPDIWQHVIHMIAVVVDEESCYQVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDI7</accession>
    <name>A0A0D8XDI7_DICVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716750">
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    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XDI7"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679:SF2">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21679">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039979" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="9916" checksum="A4CD4E9835C95C10" modified="2015-05-27" version="1">MIFFMLLTLTAKSFAQNEITFDNPGNCGTATTNWKPCIERKVADQVFGSCCERFVPPECRGLCIYETNAIEARVVVRNISNFFSLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDZ1</accession>
    <name>A0A0D8XDZ1_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716727">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11606" checksum="421E513A4E4E9B57" modified="2015-05-27" version="1">MACFGRYKLALNETSNRRKEEDVVRMSSEKLCDLRLLRRNEAYPNTLLSFCHRGDTTLTLAIDERIDCGEHRHADVASNETNESVEMNGNDKKKNLTSMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEB4</accession>
    <name>A0A0D8XEB4_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">DM13 domain-containing protein</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716710">
        <property type="protein sequence ID" value="KJH42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
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        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335708" description="DM13 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="28"/>
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        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="150"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="457" mass="51610" checksum="CB3EFABA55EF58A8" modified="2015-05-27" version="1">MLLGKVVLLTIGISVFAEEINSYNPEYGTFIGELPNLADGNIHGKVYIVNDTTLQIINFTYNGNAPDLYFWMDRKEHPTIDGIKIPSFEYGITPLGKYEDVKRVVLTLPGRHKFTNFKSFSLFCYKYEHNFGSILIPDNLIIPRPQFLAGELKGSRYSVGSGPILILDRRTIKIFGFTFDADKAPDGYFFIGRGPNVAHDSGVKVPIRGRDTPELITAMNERYRGGQDVIIELPAEYDVQHVDWLAVYCYKFRVDFGHVAISNVSSRIPPYVPHQKRFDDITTTIDSWPVASLLGNENRRNFTFQLGAPGGKKGYQSMARARSAKYVWYVNGMLAEIYLKRGITYTFIVEGGSDKSTSDFFNPLYISDDQFGGYGKLSNEEKEQVTVFSGPDPSRAAGRLCIWSNDDNTDPSIFSTFAEFRKTLNLKCERDKAAALLQFTPDEKTPDILYYQVSDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGF7</accession>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716818">
        <property type="protein sequence ID" value="KJH41466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGF7"/>
    <dbReference type="OrthoDB" id="5849309at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="65" mass="7332" checksum="0A47E8B4A5CB4298" modified="2015-05-27" version="1">MEQGGAAAQICFPLFISLIMGEIYSKLDIHSDLIRQRGKAKAAGSHRLTSELTKRWRETIKEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGR7</accession>
    <name>A0A0D8XGR7_DICVI</name>
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        <submittedName>
            <fullName evidence="6">RNA pol II accessory factor, Cdc73 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_11093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716611">
        <property type="protein sequence ID" value="KJH42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGR7"/>
    <dbReference type="STRING" id="29172.A0A0D8XGR7"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="13274" checksum="FB0DCFA01BE6ED48" modified="2015-05-27" version="1">MTQQIGFFQVPNKFTDAEWDRVVAVFITGQLWQFKPFKRWHSNPVEIFAKIPAFHVHYDDLNVDTNVAKWSVTRLPVSRTKRHMDKARFRVFWEVLDRWIPANRPYLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHG1</accession>
    <name>A0A0D8XHG1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein GPR175</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716504">
        <property type="protein sequence ID" value="KJH44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XHG1"/>
    <dbReference type="OrthoDB" id="10027388at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47845" checksum="19996F1D222356EC" modified="2015-05-27" version="1">MSVLFPDNPGTSLGEAKFSNFTKRIPQESPEWIANIFPNNSFIDSETHTTIKGLCRDVLLFELPILGHFVSYANLLITKRVRCKTLRHHLKAIFIRNPIKVYLTTSMNIVRCVVSMSISAANPVGEVVDKILWVTLKFFYMTSELSVLTFALLFGHLDSSTSIRRALIATLMISLAHTCIQSVLEMKLIHQSVSDGFFDLHSQGGLLFWMLTSTAFALVYLFVLCLPITCVRRYVTLPSKWSFYLYCIILSFLNVLQAFGAILLFFQANDGMCFVDFSTYLYFCFYTPLVYMTFLRRSLKHPNSNSGNSLFSYRKQRDEHGSGDLPESYYPRFSGLTSPSYDDLFDCSPRFEAVSFPDAPLMLFTSETVESTVTTRADSNEWDARHSGHWDNNVEARHLKGLGANGSLVFDDEPYPRFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHR1</accession>
    <name>A0A0D8XHR1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716493">
        <property type="protein sequence ID" value="KJH44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XHR1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000033">
        <property type="entry name" value="Glutamate carboxypeptidase 2 homolog"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="10">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="11">HannoverDv2000</strain>
        </source>
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        <source>
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    <sequence length="179" mass="20496" checksum="4C3C89FE0C91BEAC" modified="2015-05-27" version="1">MYLEQQLKPYEWFLPKSLCQIVPYTETVSLSVSVFTLTASAVHEFRTVFFSKNRRLGNRSVRSFVVIIWVIAVVVSLPHGLFHKVYDIQDGNLIISQVFARGEANIEKLSSVDVFARGEANMEKLSSVDGMFEWKTHKPHGTWELSCRCLYRKPLILYTTPHFSASSTDFMSCDTTSKM</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="153" mass="17188" checksum="E61488DF80B6576D" modified="2015-05-27" version="1">MSSIIGFYSGWLTSDWSECLPICGRGRRTRSVYCVHQALNETLNVPEMYCVNQTKPNSEELCASESCGHWLTGQWTKCSATCGQGIRRRTVECVNGNDCTLTSRPISEEICYSGIPCDAHIEGSHPWIQVDNRSVLVFYEICMLFSMTTNLTL</sequence>
</entry>
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    <accession>A0A0D8XKZ6</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="69" mass="7996" checksum="390B111B5C3335B0" modified="2015-05-27" version="1">MGKAVGQHLKFLEIDECRKITEFGLKHLELCSGLKLLILRNMKRVHSPEKVLERLKHALPNTEIHFPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLF9</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716406">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026627">
        <property type="entry name" value="NDUFB2_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14813">
        <property type="entry name" value="NADH_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="395" mass="46620" checksum="33BFA12C7FDE1158" modified="2015-05-27" version="1">MLEEKNNSNCLETEKLLKKYDEVKRSVTAKRADFKTLPKCERGPALRRALKKNKRARQAEREKIREALGDNAPAKEVPKTIESTREYDETMVDDDDEEVKHDEANDEFAHYYNSEIVPKVLITMSPFAKKTTWKFCFELRKCIPNAEIFARKGVPLKKVVKQASMRLYSDLIIVHEDRKKPSLSLLLNQCFRITHQITFAFHSYYILIWLTYNHCFLKLRLSEMEMLTICIARMFGCLFPRNPKYVGRRVVTFHNQRDYIFFRHHRYRFVWGKDAVGPHVPVGFKMGAPENPELHTHDAVYRGTPSKGDKLRPDFIYRAPCVGTTYIERCVTKFISALLWFWLSYNLYYNPGHIFGHFYMPYLHEFTDEELGIPPDSAPDPEYWGNHDKKYGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLG8</accession>
    <name>A0A0D8XLG8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716458">
        <property type="protein sequence ID" value="KJH44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XLG8"/>
    <dbReference type="OrthoDB" id="5912827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019546">
        <property type="term" value="P:L-arginine deiminase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271:SF2">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19420">
        <property type="entry name" value="DDAH_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="21088" checksum="11AD55F2218354BE" modified="2015-05-27" version="1">MLDDKLVFRTGEQVQYLKWFKSQGMRILGDDYPDFFEGGGDAVFSDPMTLWAGFGQRSVKKVYERVKVLGNFETVICELIHPDFYHLDTCFAPVDETCALWYPPAFSEKTQKEIVHRLPNSISISDEEANAFVCNAITIRNTVISPIGMKVVTRNALENRQMAVVEIDMSEFMKSGGACQCLVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM55</accession>
    <name>A0A0D8XM55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716397">
        <property type="protein sequence ID" value="KJH45630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM55"/>
    <dbReference type="STRING" id="29172.A0A0D8XM55"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="23081" checksum="3037BC3355806270" modified="2015-05-27" version="1">MPKNKGKGGKNRRRGKNENDFMKRELDTKDIGQEYGQVSKMLGNGRVLAFCFDGKQRVCHIRGKLRKKVWINTGDIILVGLRDYQDDKGDVILKYTPDEARRLKERNELPEHAKINENDEQEEGEIEFRDLGAESGDDEGEEEDDNMPSSGNDESEEESEEEEEGTESDDDSDKFVNEESLARGHGLKPSGRGGRNKYNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM96</accession>
    <name>A0A0D8XM96_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAAT/acyl-CoA thioester hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716389">
        <property type="protein sequence ID" value="KJH45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM96"/>
    <dbReference type="STRING" id="29172.A0A0D8XM96"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="1">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="294" mass="33205" checksum="BC09B68F1D604FE5" modified="2015-05-27" version="1">MVSIKKHWMHPKLERIEIEEDGFCGTLFKPPGDGPWPAIIDISGTGGGLHEHKGSMLASEGFVVLCVAFFQYKNLRPIKWLKRQSFTTDRLGIQGVSYGATIVILLATRYPQINAVVAINGPHISTDYFNVRENKELLPQAILAVDLFYFINNIFASDKAIQHAKFDDEAEIPWNRIHPDTSFRFVASLDDLVSPSVFSTRYMLKCLKEVGREVEVQFVSGGHIVEPPYFPHHDVVFAKFQGCCCGYGGEAILHGTSQEISWERTIKFFRRKLGPSAKMPDWNRLSCIDVKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN33</accession>
    <name>A0A0D8XN33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716423">
        <property type="protein sequence ID" value="KJH45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN33"/>
    <dbReference type="OrthoDB" id="5820918at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335963" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="12734" checksum="617CC51082702C57" modified="2015-05-27" version="1">MYIVVISLLIVTPTVLSKDVYELNEHEKRRVSSFDTLAGMGLGKRAQLSSIDSLAGLGIGLREGDLLYQNVKKSLSNFDTLGGIGLGKRGYLFPRKFFVPYRTLMESKYRNEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNF7</accession>
    <name>A0A0D8XNF7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 9">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 9"/>
    <dbReference type="EMBL" id="KN716417">
        <property type="protein sequence ID" value="KJH45267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNF7"/>
    <dbReference type="STRING" id="29172.A0A0D8XNF7"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="10">
        <location>
            <begin position="12"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16906" checksum="FD4B3E8E013FD307" modified="2015-05-27" version="1">MCPIVFPEGVWSFVMWDYHVILLQLVETSTSHIWDLDSTLPFPCPFDDYWNETIRPAKWNIPAKYSRYFRVISCAHYLAQFSSDRSHMKRQDGTWLAPPPSWELICRNGQNNIEKFISMDPNVMSEISTVLSEDEMFRKYSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNL7</accession>
    <name>A0A0D8XNL7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">U1 snRNP-binding protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">U11/U12 small nuclear ribonucleoprotein 35 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716367">
        <property type="protein sequence ID" value="KJH46145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNL7"/>
    <dbReference type="STRING" id="29172.A0A0D8XNL7"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="363" mass="42260" checksum="C84BDBAB7351C2A1" modified="2015-05-27" version="1">MRRTRPRGGSILHKRPSKAKFAYSLRIDRSALFYAAFKNITEMTACLPPNLLALFEARPPIPYLPPPTDLLIDKREKGRCINITGIAEYVDLFEDPMDTPPKPIIETKAEKKERRRREKEELLAYKVEQGIAQWNPADNPNATEDPYKTLFVARINYETSENRLKREFETYGKIKKLAMIHDLNGKPRGYAFIEYSDKAEMSNAYKRADGTKVDGRRLIVDYERGRTQKSWLPRRLGMFGFKDCFGDLFTGGGKGDTRRARESRAAIEEREAAGLPPLDAPRDRDRDRDRDSPRAPPRDSHRDYDRNGSSKHRSRSRERTNNRISDRGYDRDRGYGRDRRDNGYRDDRRGFRGPPPPYGRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNP8</accession>
    <name>A0A0D8XNP8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716507">
        <property type="protein sequence ID" value="KJH44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNP8"/>
    <dbReference type="STRING" id="29172.A0A0D8XNP8"/>
    <dbReference type="OrthoDB" id="5851936at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16683" checksum="2BC3F099969725B7" modified="2015-05-27" version="1">MKIPFLNWIKKSSFSRCSQYFCVGKDVTLNRRKLQICDVARSDVPIEKMSLSRGLAMNKFEKDFMIYPEYTDTDDVRAIQGFTETLKKALELVGIIINNQAIEVVSLWKAKIRFAAPIEEFLKTELWKFAAERLTKMLPRPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP12</accession>
    <name>A0A0D8XP12_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716405">
        <property type="protein sequence ID" value="KJH45487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP12"/>
    <dbReference type="STRING" id="29172.A0A0D8XP12"/>
    <dbReference type="OrthoDB" id="5867267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="432" mass="51160" checksum="C318B419391E7700" modified="2015-05-27" version="1">MSVADEDFQLDADIENNHMLCTRKRTRCNGEIDHINKFMRVSMNSALNNRKLSGAYSEVAGRIAGVEIENFMCHGHIKIDFDTTNNNCFYIGGPNGKVGTLDHLRIHYCEVVDLFLFTLFVSFLVKLKSDSCSRIESVRLLRLIRPIFLKLYLELEKIEEVGQFVHYRFIRDFECFEPIFMCATELEHTKTCYDHCEAITTAVETICKSMKEEFERMKRKYQIMVEQRQQLRNINDMRIQQSEIGWMLLWCPLRDVNEEIHIFERKKDKFKCELNHVDRRVEESMEKINVCSISFVFLCYVKYSLEISSLQSRIDAEMEELSNLNVEITERKINIGNVKNEMTNDNAELRRLECNRTSYEKRRDLLKEQIAKFEEECQSEKRKKEASQTKLKLDKITQKESKVIECLRLAQQERDELQKVHEQVASHYEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP87</accession>
    <name>A0A0D8XP87_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Immunoglobulin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716358">
        <property type="protein sequence ID" value="KJH46340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP87"/>
    <dbReference type="STRING" id="29172.A0A0D8XP87"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF8">
        <property type="entry name" value="IMMUNOGLOBULIN SUBTYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="79"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="29882" checksum="84DC28681DBD43D1" modified="2015-05-27" version="1">MRKVRQGLREFWKIRLSSDKNVVFENRSYTAEQPVPEVGFLIMSNISKDDEGLYWCRHTETGIVGEVFSLTVAYVDKIPSDKHIKVEPPYPLIGEQVMLICPVPSAVPHPAINWLLNGEPVAHSSVDAQPYANGTLVIRRFSTVHNGLYECVVWNFVARTSSRTIIDSKHMADRSVHSGSNAKCSSLFRSSILWFLIGCLVTSCSVLFYLLCVLVLMRPTSRATIVPLMWSRSNPLLGPGFRKPVVPMPDLITGERTSELQSYQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPA1</accession>
    <name>A0A0D8XPA1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716399">
        <property type="protein sequence ID" value="KJH45582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPA1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12154" checksum="EF1130185F53ADE5" modified="2015-05-27" version="1">MRNASKDEAKSAVASKKDGDKKEDAKKGAFHIQLPEDKTMMPQQGEDQKDGKPSKAPQNEHIKIPGNMQWTESAGTQLSYPPTSVQARKKIEPFFNRIGTVKEMLPIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPB9</accession>
    <name>A0A0D8XPB9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 22">Exonuclease 1</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DICVIV_07437</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EMBL" id="KN716350">
        <property type="protein sequence ID" value="KJH46488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPB9"/>
    <dbReference type="STRING" id="29172.A0A0D8XPB9"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 22" id="KW-0228">DNA excision</keyword>
    <keyword evidence="17 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 22" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 22" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="12 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="24">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="23">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJH46488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="588" mass="66389" checksum="78422257C59FE101" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPK5</accession>
    <name>A0A0D8XPK5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716351">
        <property type="protein sequence ID" value="KJH46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSJ9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012813812" description="DRBM domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14769" checksum="44BD0EC1EF99F7D2" modified="2015-05-27" version="1">MSIWSMILSIWSVRWDTITYYLTGSESSIQEVRSHYTGQHIYSITVKNTSENGSSSIISQKEAVLRGVYEALRYSNPQINEGEVNNATDEIAESEEHSNAVLRVLREEPFEKKSTEVSKQQQAEERHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUH4</accession>
    <name>A0A0D8XUH4_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">MTP large subunit lipid-binding domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716305">
        <property type="protein sequence ID" value="KJH47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phospholipid transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MTP_lip-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
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        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19444">
        <property type="entry name" value="MTP_lip_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
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            <begin position="246"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF19444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="54940" checksum="FFB105EE0D403D68" modified="2015-05-27" version="1">MENNFQYWLADINNNDALYWKVANTIATVLKRRCDQTISKRKSCHMGKEKIVSKFINDISKCQTEQCSLKSLHVLRNIPISTSVEMARGYLCSTHSTSLQIAALQLIKAASSSLYDSKARADVPLYFTHFEYIERKQFEYLAKLTLRSKIFKFKTSEILTTTLIEKMQKLRCIPDQQHVGTMLFRTETLNPDNHEKWQYLYKAVKSTGQQDILFVMDVTGLDSLDFGQTMSANPQAEFRLSVLGHSLPPVTLFKNSAELMNIVWNANGQTIKAFEGNVMLRDTSSTIPLLSGLTVQVSSTGALSLKLLTSALVSLWNQQSLGSMKANVSMSLQSSAFLLHHGEIIQKFTSDTAMVTTIGAEARVSFVNVPFDVCLTIQSGDVYIRKGPSAETDDNQESGEKNCMEKYYVKTKDEKKTPKKKPSKSPKKKGKRSKTKKSSRRSKGGNTLTVMLYIVVMLLGISIVVTIIVVLHLFEALSLIPVLLPPNCVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUI5</accession>
    <name>A0A0D8XUI5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin</fullName>
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    </protein>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the actin family.</text>
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    <dbReference type="EMBL" id="KN716305">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="255" mass="28937" checksum="45BFF40AB9ADD6A8" modified="2015-05-27" version="1">MQGYKYAAIVIDNGSGMCKAGFAGDDAPRAVFPSIIGRPRHQGVMVCMNQRDSYVGTEAQSKRGALTLKYPIEHGIVTNWDDMELVWQHVFTNELRVSSSQHPILLTETPLNPKANRERMTEMMFESFHTPAMYVAIQAVLSLYASGRTTGIVIDSGDGITHTVPTYEGYSLPHAVHRIELAGRDLTNYLVKLLTERGYFFSTTAEREIVRDIKVNFQSIFKLLRDYNESSIFKSILRHKQMNFLKVSRKIAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XUN6"/>
    <dbReference type="OrthoDB" id="5872055at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16137" checksum="1D27659A88693778" modified="2015-05-27" version="1">MHDSSDFTFLPPLSSQQHASGGRHEHSPVKQVQVHTFSSQTPTAPVKAVPVPSQRNAFTKIEERRQGIKDNENEENSAIPSPSMRGNSTLKRTASCQSGEMASIPSVENMTLPPKLIAQIVLHLEFLGVTLDIEQLRVHVFFIIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUZ0</accession>
    <name>A0A0D8XUZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUZ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XUZ0"/>
    <dbReference type="OrthoDB" id="5815677at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="786" mass="88755" checksum="6E89063B3D8E00E9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV33</accession>
    <name>A0A0D8XV33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716270">
        <property type="protein sequence ID" value="KJH48370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV33"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="154" mass="18060" checksum="46E899E9B9108240" modified="2015-05-27" version="1">MFGRCTVNTSNDCDSFLKKRRNKKSKFSSREFSFYPPPPPSFPPSDKTLILLTFVFLDLIDGIDVCHKLSNRDVLYKCAIEISLDINKPRRSRIRKPSYFAVVSERHRRHPPRAVLRNLLTFAFPAFTFDYKSREKWRKFAGEDLNRAVEVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV76</accession>
    <name>A0A0D8XV76_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XV76"/>
    <dbReference type="OrthoDB" id="409763at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="418" mass="46494" checksum="F5FAC18E2395161D" modified="2015-05-27" version="1">MIRHLQNGLHSINWPTYVTIPARAFSSREELFEKAQENLKKLPEEPDVDIKLQIYALFKQATIGDVLGSRPGMMDFAGRAKYDAWSKVKGMPKEEAQLKYANLVDSLMSKRSELLNNNEIPMGLKAVEGLNISVEGKAFKIRLNRPEKFNALTLDMYNGIIEALKASNEDKSTSITVITEKFNALTLDMYNGIIEALKASNEDKSTSITVITGTGNYFCSGNDLANFAKAASAGKEEIKEMAENAAVILKQYIQAYIDHEKPLICLINGPAIGIAVTVLPLFDYVLATDKCTFHTPFSTLGQSPEGASSYTFPILMGQLKAAEFLIFNKKLSAQEAFERGLVNEIVPYEEFETRAAAVVNHHSSLPSESLRINKMLLRSFHKDLLTKVNEIECKTICERWQSKECASAISAFLSRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVA4</accession>
    <name>A0A0D8XVA4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVA4"/>
    <dbReference type="STRING" id="29172.A0A0D8XVA4"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="36483" checksum="E244BEA2A0959675" modified="2015-05-27" version="1">MARVLEGQIALVTGASRGIGRGIALQLGQSGATVYITGRSPEMSLQSQYQNLPSLEKTANDIRQRGGKAIPVYCDHTNHVEIAHLFDRINNENNGKLNILVNSAYSGVKDMADAASVPFFEADPLLWDAINNVGLRNNYICCVHAARMMVKRKSGLIVNISSAGGLQYTFNVPYGVGKAALDRMSADMAVELSPHGVSVVSLWPGMVRTEFAEVLRSEDKLEKMVQQTKEQLDKAFKESESPEFAGKAVVALAADEKVQKKSGKILMTYDLANEYGYKDIDGGMPMDIRRVTTALEFFGFNRFANIVPSFLRIPLWGMHFASYKFPYKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVB3</accession>
    <name>A0A0D8XVB3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="7">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="7"/>
    <dbReference type="EMBL" id="KN716263">
        <property type="protein sequence ID" value="KJH48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVB3"/>
    <dbReference type="STRING" id="29172.A0A0D8XVB3"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000005">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF20">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="326"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="463" mass="53841" checksum="8FC1E0F39181F312" modified="2015-05-27" version="1">MKPAKLLQRFAFQYFPRTARAPNQAQKLDTQHSAEAIREAVMRMVSNEYAIARYPDWPNFSHIVVNSQSTYGHLWDGVPDSADYLAIIFEQYDGVGVQFILDLLSRSRVLGARRALSNSPLVQMLRIVQFPTVALFKRDHQHALYMQPFTISTYSDLDNVILNDSHNSRPLINLLTTTRRPIITTTTIPIVDCQRNPYKCRDLYFVSETDMLKAMRMALYDEVTRTPGDIRGENFTALTNFVTLLSEHFPILTFSNDIRRSRGVSVILKNSDRARLIFIHMREFLKSRRNLNTIAVDEYKRQFENVERVYAYPFPVSSQWQHCKGTTPMFRGYTCGLWTTFHALTVHTYIDTIRDNTMDPLKPLKAIQGWVQSFFGCQHCKRHFMAMTTRIFPMNERRVRHPHDMMMYLWRAHNIVNNRLHGDPTEDPQFTKMQFPPPFLCPTCSAGGQFSRRQVSISLAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVD5</accession>
    <name>A0A0D8XVD5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716262">
        <property type="protein sequence ID" value="KJH48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVD5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="11585" checksum="977C38439A89A1C9" modified="2015-05-27" version="1">MGGATREILLDPAYGCIKYVSGPIPSGAGQVPPAPYASANPNIGGGGNVGPSYAGVYSNPPSVSKNLVYKTLKTYLHPLLNLLAIKSTTSDDDTPEFLIRNENLRYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVV7</accession>
    <name>A0A0D8XVV7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716350">
        <property type="protein sequence ID" value="KJH46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVV7"/>
    <dbReference type="OrthoDB" id="5864875at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="12308" checksum="1D1DD43DBF4EFA1C" modified="2015-05-27" version="1">MPHHTQTLPDPKKQLAGDFPSQHSKRSLIKLEPLEQRRFRSVESRPITTSNYLTESVERHRDMEASRLRDYLKAKESDANKPWAKPGWPGPKVRCLAIKGWLTKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWC0</accession>
    <name>A0A0D8XWC0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Globin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWC0"/>
    <dbReference type="STRING" id="29172.A0A0D8XWC0"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="29012" checksum="D06AFAED1E1FC21A" modified="2015-05-27" version="1">MVMENMDDRDYMRKLLNEIGAHHFFYDTCEPHLELFAHIMLRSLQNPAINDQKMDADTEQSWKRFLSDVKNFIGEGVAIQRNTYLRECMTSTEIANIRSKWEHIVAFGMQEAGEILCKTAIKSYNTMVMAHNLSMLMPFKKQSKVFSEVAVATMKAFEVTINSHTEIVGFCDLPVSIKEFVVSCMVLEICPTFVRKAMMEGLFVMLSKVFGEEQLNECLLRTWSKVYRALEQVKIFQFVYRIYASTFVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWE5</accession>
    <name>A0A0D8XWE5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_04933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWE5"/>
    <dbReference type="STRING" id="29172.A0A0D8XWE5"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="8">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="182" mass="21480" checksum="B9DE519FB84C93CD" modified="2015-05-27" version="1" fragment="single">HISIVVFSNTNVISTWRAVIPCERFLEQNNNSFTRMRIETCYFCSSPIYPGHGIQFVRNDSTVFKFCRSKCNKLFKKRRNPRKLRFTKASRRARGKQRRDIPVKYERELFKSTVEAAKLVTKIRHKRYANLIRKSLQPGKIVQKAGMIKKAETKLHLIRAPVANKEAVKQKHKEEEQQMEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWL1</accession>
    <name>A0A0D8XWL1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase alpha catalytic subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWL1"/>
    <dbReference type="STRING" id="29172.A0A0D8XWL1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="14112" checksum="8A3A4A9B066242C2" modified="2015-05-27" version="1">MSDAENFNEVECRRSSRSRESARVQSRRSALEAMKEARRQGRGHRVDLDNLISNVYEEVDEEEYNEIVRTRQAANFVVDDDGSGYVDHGADIFDDESCDEDDEINNKIKKKDKKGLLKANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWR2</accession>
    <name>A0A0D8XWR2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCDC92/74 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716274">
        <property type="protein sequence ID" value="KJH48237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XWR2"/>
    <dbReference type="OrthoDB" id="5856504at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16984" checksum="3BBAAA19824A03DF" modified="2015-05-27" version="1">MSAVSESEYFQKCRYIHEVELVNMKLQMRILETHLENKDRLIRNLEDIIDEQETRISHMEDFIQGRANTYTPSSKILKGISVLSLDFGALRDENMKLKVALTEMHKNTRLSQLTEDDEDYESDIPSSEDRFRVRYCFLSNLIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXG4</accession>
    <name>A0A0D8XXG4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716265">
        <property type="protein sequence ID" value="KJH48517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXG4"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336292" description="Transporter, major facilitator family protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54676" checksum="EF68C25F21A4B412" modified="2015-05-27" version="1">MSLLLFLLYVIFPLVTSCRIFRIFIAAMSNACCDVIGMEIPLFIYMMTSFLKYPVFQNLIYEKSCLLRYENSSICSNVTAYHGDKLIQADANHFYLLSSVVLIMPSFFSTLLLGSAYTTFYAEFEYVANFLRLSSVTDLWSVKKPLLIPFFGLIICTSNYIIQTVNMNASIYLLLISDAVFGICGGYIAVLVTTLSYGVKKTSTSRRSIRIAGFEGAIGLGGTVGYALSGTVRELLGYSYTFLLMLILQILGLLYIMIFAKEYGQPQNTDKEFVDGGYVSTLFRKCLMALSHYRQLLTDSRQFLAILRLNFLAFGVELFIFGGLMDIQYSYLRYKLGWGDKQYGWFSGLHFGVSTLAVSVLYPFLYLRGFTDGTLGCVGLVTKIISLIMFAFLSSTPIAYSIIRKMFSLIALLEGATGLLASAVFNTLYPKTLSFFPGLLYIISAVLSIIPLLILWISDRVVKSKGFQRAESNNEINLQHVQSNTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXP2</accession>
    <name>A0A0D8XXP2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maelstrom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXP2"/>
    <dbReference type="OrthoDB" id="5802353at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55488" checksum="A246D86B99E3AABD" modified="2015-05-27" version="1">MSIENRSTATQGRHRGKAKGRLKVCRNKYSDFWCWFIKVGSKEFREKYGRNYDETDENDRHLIGQLWILVKGSYDQNSQQKFNGNYTPQSVGNVEITKSLRTLRGPSHSSPYRSTSFQNCPPISCVVSDFSNVVLQFLEVLPYPVISPVNGHVLICPAEIAVTNFTLANGPTFHSEIIHFDRNLSYDCSSSYYEKNNFYFWDQDTIRQNAVLVNVLIKQARGKTPQDMWRTLIRNRNSCEITVCDARNILVVERALLFLASTAGVDQQPTYNEIMDTMVTAQDLVIALSSHYSDVAGMCVSNYLSREKMDREFEKPRTTSICCHYHENTILCHKSRQFCPVAKTAILIDAFYSLCFSANVDDFRTKYRAQIHRFTDIDSDEDTPHTTLSKFAQFFHISSRCFLQRVLQLSRSRECSSDFDQTENIETEREYSQQNIFVFRYTVVSIESSPFVRRRKVEIDLKDAISRLLDTPTRFDQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXS6</accession>
    <name>A0A0D8XXS6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXS6"/>
    <dbReference type="STRING" id="29172.A0A0D8XXS6"/>
    <dbReference type="OrthoDB" id="5810603at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000060">
        <property type="entry name" value="Protein CBG03800"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="336"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="484"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="664" mass="77731" checksum="DDFB20528E07C09B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYV6</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">DICVIV_04211</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5813366at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="65" mass="7386" checksum="6612E04A3D644151" modified="2015-05-27" version="1">MSDYLRSLILFILLGFSVALPLLWLDTEGELHYEPQIPYLRFGDLLSPEKRNIAIGRGDGLRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYY4</accession>
    <name>A0A0D8XYY4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chondroitin proteoglycan 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYY4"/>
    <dbReference type="OrthoDB" id="5773441at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26572" checksum="7E17706CE0920E5D" modified="2015-05-27" version="1">MNGMQQSLAGVSSEWTVDMVTPLQALLSQSHRAQLFYRMDSVCRLNTVYQSCLSSCPRNPAKRILLNGQKTWNIICDDFRNDTDFRETVLPCWAKMGVTLTNHCAPMASLLQVEMLQLMEGGLENVQQGMDGFCRSVHFYDKCFVGKNYEACGVKAGRFLIKLTQQTSHALMELLDNVLKLENLPDSCKEWLNQKDTDDPRPRAIARRMKNNKLSFTTSISIIFLMIRTYLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ38</accession>
    <name>A0A0D8XZ38_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ38"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ38"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="17228" checksum="03A9C34BA0787CB8" modified="2015-05-27" version="1">MIPKGRNSVEQHLVQYGRLQYVSVPRHLAPHTTIAEVMGVDIEVIKSGDVLCHCLRKLQVITLGKTFPKTGQTVTCHYVLTLQDGKKVDSSRDRGSPFKFKIGKGEVIKGWDQGVAQMSVGQRAKLTISPDLGYGSGGVPGAIPPNSTLIFDVELISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ91</accession>
    <name>A0A0D8XZ91_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_04115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="258" mass="29625" checksum="0D3683BC5AAF198D" modified="2015-05-27" version="1">MEYLNHCSPIDYWHLETIQCAVKMYSFREDRNNCTNHATSSQRGRPLAHTISSNTDIYHTYRPYHNLNQSVYATPSECVNSYQMNRTIHVCEKIDDSFHDISCSQKKKKSRVRIALKELLGKSFRRDSAVDLCGRSAHRSELPKKCHDSVANSRIRYAKVASENAYCARKVDSREDFLLALEFQRDRVRRRNRGPIKLDSSVASKPIEIAKNRKSSDDAFVNSHEWTLSRSVSELRLTSTVLVIIGSAAGLQIRGDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3A5</accession>
    <name>A0A0D8Y3A5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_02455</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716185">
        <property type="protein sequence ID" value="KJH51338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3A5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3A5"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051583">
        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH51338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="307" mass="34758" checksum="6A73E9D04F29C794" modified="2015-05-27" version="1">MHSNGLTSNTVLQVEPILKESERETWSSKVDFLLSVIGFAVDLANIWRFPYLCFKNGGGAFLIPYTLMVLLAGIPLFYMELSLGQYYRKGAITTWGRICPLFKGIGYCVIMIAFYTDFFYNVVIAWGLHYLYASFSINLPWASCSNSYNSPACYEPHKGFLGLHEAGDTTSHVARSLDNLGNINWQIAICLAIVYLICYFSLWKGIGMSGKVVWFTALFPYVVLGILLIRGITLPGSEMGIDYYLRPNIEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNHFHNNVYMYALNQILINFVDKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3F7</accession>
    <name>A0A0D8Y3F7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3F7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3F7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF10">
        <property type="entry name" value="MYOSIN VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="103"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <source>
            <dbReference type="EMBL" id="KJH51230.1"/>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="4">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
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        <source>
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    </evidence>
    <sequence length="103" mass="12087" checksum="584377D06FE30D14" modified="2015-05-27" version="1">MPKSITQRSHSAEEKVYHDVWSRLYMDKRNALKKTKDVEHRTMKLRTESESSSTPKLPQSSLQLKPPTDYKFSTLDSDRRQRLAANQDVLDRQTDELRKLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="464" mass="54367" checksum="5A5AB41E2A3BB698" modified="2015-05-27" version="1">MTQRQLYLSNEETIRAKDLEYRSLKTKITSAELHAREKDSKIDQLTAQLENMRMEASEMAEEKQKLSSIVKAAEHEVKAVEEEVEKLQDERQLLATQLADAKISHGRLIDYESELQRMKILLDDTRKVQNKEREQLEKHRSDGKVSKQVDVVAKEASGGNCTSLLEEKLSQLQYSYDMLLSRNYALVAEADRLRKELCESNHRFGQLNFKLSECERSLEDANQTKQKLVQQITTFQKMENEWEKLEREMRDELVILRKDRLVLTSDHEELKRKLVRAEVEKKEVDGLRARLDREVASLKKHVEALEEDKSRTEAAIRNSINERRAIDKSLAAMEKENAELYRNCAQLQSQIAHLERDSDPNSIAKVLKDQGQLEARIAKLVIEKEQLELVIERKDMKYTQKLRVMESQLAMLRNQLELEKKRKIDMQKVTRGDTDAQQHHFSRTSDLRMNRTKSIRRQVNPFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y557</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
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    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
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        <property type="entry name" value="Tam41"/>
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    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH51144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="34384" checksum="A0A2CBCAF4D4149A" modified="2015-05-27" version="1">MLMNGYKELLERLPLSTIEYAFAYGSAAFQQKGEDKEDKMVDFILSTNDPLLFHKENIKRNPSHYSLLRLIGAKALSNFQTRFAARVYFNTRVKASSRRMKYGIITTEDLNRDLLDWQWLYVSGRLHKPVLDVNIFSIISLLLLPDSFTLEELYEEIVALSYSGDFRMCIGEDRNKVKKIVHGSMAELSDIYLPLLTNDSRIVVQNGNVTIYHRLNLLPSAVLSAVKKNWNKKNKLQKDTEEVLFLLAHRHDVSSHVLAAISSIIAPVAISQTVKNAVSAGFTRSVIYGVSKLSKMIRSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y584</accession>
    <name>A0A0D8Y584_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="297496at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF312">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="483"/>
        </location>
    </feature>
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            <end position="514"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="573" mass="65009" checksum="33B037B23A996640" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5C0</accession>
    <name>A0A0D8Y5C0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GH25_Lys1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336206" description="Glycosyl hydrolase family 25" evidence="3">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31268" checksum="7F195D670D48A1D4" modified="2015-05-27" version="1">MFLVLLAISLCSTSTSLHILPQKVPAVENTNGISYALDLSQLVSPTTFQCIRRYGYNVVFLRAYSPYNQGQVDPNIVSNIKNAFYAGLGTEVYMTPQPNSVKTGIQQFDEMYSYLTTSGIKVRTVWIQVTSPINWSYTIARNTNFIRNILNRARQYGVNVGIYTNVYDWNQITNGLVVNNAMLWYWNVFGPGISGESSSDFGDFRSFGGWNKVMVKQFAQVESVCGVTVNRDIYKTASMPSSIGISKLTAPIEKSESMKPQEIVVGGLGLSDTSTFAEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y683</accession>
    <name>A0A0D8Y683_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y683"/>
    <dbReference type="OrthoDB" id="5788998at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="316" mass="35732" checksum="325EA760DA5AE8D0" modified="2015-05-27" version="1">MCFIGFITEVTFMSQNILLLVHECNLQLALFRNATQGIGTSHDGASLRREVETAGRACLKACEAAKNCVLPQLRHEGVEFTRHASQFIGCVAAYVVEMKRCVALEKTFPAPTEPSITPQQWRLCTNMCRLQWGTYCVVDVLLTVYTLSKMLVKRKLHALHAVLSFGGWRSIGYLPSKFCIGLRDAESIIANMESMLVTLENLITVHFSTSESSPTDKPRRVELTMFNVKNSNLLMSFPAPYLLSLPLLYYATMFILKNASHGQMDKPTRTWTTLIHHQQQFDKKVKTLATYGSSYRDRQLSNDTTRNHSVRTAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6K4</accession>
    <name>A0A0D8Y6K4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative aquaporin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aquaglyceroporin that may modulate the water content and osmolytes during anhydrobiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6K4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6K4"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="31834" checksum="7DE00098BFE44A06" modified="2015-05-27" version="1">MIDLLCYMDKIRSKVHIKNDLGRALIAEFMGTALLLLIGNCVVAQSVLPRPKLNEMIGVNVGFGLAIAFGVAISAKISGGHINPAVSLMFLSFRQLAPVRFVLYTLVQTAGAFVGSALAYALYHEAINQFDGGVRTIDGVKGTAGIFASYPAAHLGLFNGLIDQIIATAVFCFLIAHITDKKNSYPTWLQPLLIGLSFVAVGAGFGYNCGYPCNPARDFGPRLFTFIIGYGGDVFSYKSWFWVPIVGPFIGALIGAWLYQLAIGFHTPQDVEEKYVVLTGNQELKPLTGKDGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Z1</accession>
    <name>A0A0D8Y6Z1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716209">
        <property type="protein sequence ID" value="KJH50346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Z1"/>
    <dbReference type="OrthoDB" id="5867550at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13853" checksum="CCAD20B7AE43FFEA" modified="2015-05-27" version="1">MGCFNALEQWKYVILCFKTFKNETACSYNVETREGFDHWGFGVCCCRSEKCNQLPPDWLCLPRWNSWWRVFSNFLILFSFLSLLFFTIGCCEGTYTSRQELKRRGSLSSESGSGHKDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8R9</accession>
    <name>A0A0D8Y8R9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8R9"/>
    <dbReference type="OrthoDB" id="5792770at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="9872" checksum="99A7404382AFAF1B" modified="2015-05-27" version="1">MVFHSEKVVTERKCGGIEDAIGCTLYNSKISRKVRHLLSKDHSSVRRETSTLFVEVCSESCPGGECFNIGSRTIISNLLLTILLPLYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9H0</accession>
    <name>A0A0D8Y9H0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9H0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9H0"/>
    <dbReference type="OrthoDB" id="5872864at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF423">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="404" mass="43410" checksum="32F3E9690450357A" modified="2015-05-27" version="1">MDNLLTSVGFCPRSSDHYGQRSQSRYHSMHLNMQMNVPKLLDVKAVDDNFDSKKRWGKRVEIKMRHIVMESNPDIETNTAKGSYFSAVLRRFSTQSIVKKRGRSIFPDADLIGEINEIRYKTIVIVTENYHIDRVINPPNATEKTESENHCELRPDPECPFGAPGLTGRDGEDGVVIVTENYHIDRVINPPNAIEKTESENHCELRPDPECPFGAPGLAGKDGEDGVDGANGHAGINGLDGEPHYTHDTKCIQCPIGRLGLPGPPGKPGPTGENGPDGKPGVTSVGPPGPKGESGSKGESGPPGSPGEAGKFSIRWISPRGEKGLPGLPGHPGKVGPQGYSGEIGKLGASGGVGQRGTRGIPGADGPPGKRGLRGRTSKRPRRCSCPLRQKALQRNFARKLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA13</accession>
    <name>A0A0D8YA13_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_01016</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA13"/>
    <dbReference type="STRING" id="29172.A0A0D8YA13"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="200"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH52809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="714" mass="83523" checksum="68C88B495200534C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAT3</accession>
    <name>A0A0D8YAT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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        <subcellularLocation>
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        </source>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPERM-SPECIFIC FAMILY, CLASS Q"/>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Tandem-repeating region of mucin epiglycanin-like" evidence="2">
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        </location>
    </feature>
    <feature type="domain" description="Tandem-repeating region of mucin epiglycanin-like" evidence="2">
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        </location>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="996" mass="91607" checksum="3C144D7A9815B2A2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD65</accession>
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        <submittedName>
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    <organism evidence="7 8">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8YD65"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rabaptin"/>
    </dbReference>
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        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="416" mass="47306" checksum="B31FCB1154F7B85F" modified="2015-05-27" version="1">MNERSSCVDQMSEIVDVSIKDSNDIRSTQISPSPTLTCEMCQNYEIKLTSTQADERKLREKLISMKCSNDRFKDELATERKFRIDAEKKMAELAAQFTDDLKSAISANVSAENSIKELYDKQRIEREKCLERLQDANQLCSSLESDIKSLARKYQELLGANRATAAEMRAEPIDLPQSADQLQFLCLQMREELIELKSARQHEQNELRDEIALLKEQLEEERNAKSALERRLLAQVNYLETQLGIAASKLSSADAVSLSNESHSRQIRDLQDTVAELEERVKQVQSERAAVEMTAQNYKARCTSLQSELDTSETVQKDFVQLSQSLQIQLEKIRQSEQEVRWQWEDDVENCSGCGASVAKTKPKPRCLHCCKIFCSTCVQHTVPSGPSRRPANVCQVCHTLLNRDSKPFFAVDPTN</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="226" mass="26744" checksum="EA7183EC5CA23A60" modified="2015-05-27" version="1">MSEGFNFRRKFLLKIHEKVGNVEETQMTPEFNNNMQNYETYHDSVTTLVELLEAVNQPDPVVLATGRVDCPKDEDPYDKLRKALEEFQEFIQEDKVGKVARICTKLENAAKTRREYQIKKRACIRHLRRFGSLEYKTLMDNREEFNRARSNMDMAKHDVKQAKTTEQIERRAVLYQQQVEIFDEKCNKLMKLLEELPTIKASHSKDLTELTQCSREYHLAMSEIFK</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="6"/>
            <end position="26"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="KJH39978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61434" checksum="8CDD65C498ACCE7B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718855">
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        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="29483" checksum="EBD6785FC793F5C6" modified="2015-05-27" version="1">MMRSPHTPLTPSPTPPPLLPQQPLSVMSTVGVTGQQPQITAPLVSVPVNNTGVPLLPVGTIPPPVAPTPILQLMPSQISPMPMHNASLLSPPVVPVNINYAVSAVKCFTRALQLAPGSRLEDTLRLLQLWFDYGEYNEGYKQLSENMKGLPIETWLEAIPQLMARLDSRDKIASLIKQVVLEISKMKPQALVYSLTVAAKSSNIDRQKNAQEMLAAMSEMHPTLVEEASMVSEELVRCAILWHEQWHDALDEASRQYFQEKNNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8U1</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="1 2" key="1">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716934">
        <property type="protein sequence ID" value="KJH41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8X8U1"/>
    <dbReference type="OrthoDB" id="5826989at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11233" checksum="F36AF7F7804529C2" modified="2015-05-27" version="1">MDKSVQASDNKPIDPITGANPFSEVTDQICRLPLPTLFYRLEAVHLGDLMRTSMNEVLEQQGLNVSVFQTQLKINLIEDLKYRFLSQDLELKKLLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8Z4</accession>
    <name>A0A0D8X8Z4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717545">
        <property type="protein sequence ID" value="KJH40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8Z4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="21981" checksum="753949197F664694" modified="2015-05-27" version="1">MKMNTSSGGGIAGGGMSRYQNNGDANETMQNPRLLQNQNDQCAVTSLAPAYVEEEPSVSLMKNSFHITTRRNCRRVTERRLKGQKKRGTGVNTVASYSEMSDYVLEDFMLLNTFKPLVYSFNAPYSSNASKDYPSAVGFLISEYLLTAISGINMQQKCFGWELRGGLGYQSFGLASIDSSTREETSGQSYSSSTVATFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA76</accession>
    <name>A0A0D8XA76_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_13376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717058">
        <property type="protein sequence ID" value="KJH40667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA76"/>
    <dbReference type="STRING" id="29172.A0A0D8XA76"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000150">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335608" evidence="12">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH40667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="27279" checksum="5E45C9F726DD66CE" modified="2015-05-27" version="1">MWQLLIIFLAYIHYSYCLPNLYSNNNPLHCANDTEIIDHLLFDISLHYNKHKLPSNPVDVRIEMWVQEVTSVSELTQDFEIDLYMNEYWTDPGLAYEILNPCQGNLSFDWTVLQNIWTPNTCFINSKKAQIHSSPFRNVFLMLYAAGYWNELTVTFVFRRRYGWYLLQGYIPTYMTVFISWIPFYLGPKAIPARTMIGVNALLAMTFQFGNIIRNLPRVSYVKAIDVWMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAP4</accession>
    <name>A0A0D8XAP4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716783">
        <property type="protein sequence ID" value="KJH41658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAP4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAP4"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="353" mass="38078" checksum="ED6207626A9F6D06" modified="2015-05-27" version="1">MIPSNCIRLSKKPLIRLLCSQVKNIPVSELTVSAVRETSAGEKRVALSPAAVKLLCGKGFNVQLCCGLKTTSQVEECAGVGACWSDDEYIRHGAKIVDCKTAFQADIVLKIRPPSLEEVPLFKEKATLISFIYPATNKAILVDLAKQKLTVIAMDCVPRISRAQVFDALSSMANIAGYRATIEAANQFGRFFAGQITAAGKVNPAKVLVIGCGVSGLSAIATARSLGAIVRGFDTRAVVREQIHSLGGEFLTIPVKEDGEGTGGYAKEMTKRYLDVLNVEISQAEMDLFAKQCKEVDVIISTALIPGKPAPRLITEMEESLFGTWISSTDSFKFPRTDPAQYDDATELDSIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAV7</accession>
    <name>A0A0D8XAV7_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN722607">
        <property type="protein sequence ID" value="KJH39646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAV7"/>
    <dbReference type="STRING" id="29172.A0A0D8XAV7"/>
    <dbReference type="OrthoDB" id="8961010at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF442">
        <property type="entry name" value="PROTOCADHERIN-15 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
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            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
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            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15633" checksum="DD3E86266571F272" modified="2015-05-27" version="1" fragment="single">GNELGYFRVDNDGRITVIHPLDREHTMTHYLVVQLSDGIAPYRCKLISPFRYCRYKPLKSNHTIDCVVTVDVLDINDNHPIFISPTEYQVEENSPMRKIIGKIKAVDADEGRNSMVSYRIIPESLPKAEFIIDAVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAZ3</accession>
    <name>A0A0D8XAZ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716763">
        <property type="protein sequence ID" value="KJH41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAZ3"/>
    <dbReference type="OrthoDB" id="8048764at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="12970" checksum="D70ADB73AADEBB4D" modified="2015-05-27" version="1">MYANSDKFSFLSTTISIRRSPPDVAESITTIQHRQMCSKKIGSGTDWIGREHLKNLPPVLTEAISRLFTCYLSECEVPDQWKISKIVLLHKKGNVQIEAIIAISAFGLMSFSFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB69</accession>
    <name>A0A0D8XB69_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721396">
        <property type="protein sequence ID" value="KJH39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XB69"/>
    <dbReference type="OrthoDB" id="5826989at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34141:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="69" mass="7738" checksum="E83CCEEE4CA67BE1" modified="2015-05-27" version="1" fragment="single">EPSVSSVLIRQSDFPSPYQFQPIDPVTGANPFSEVTDQICRLPLPSLFYRLEAVHLGDLMRISVRCSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBL4</accession>
    <name>A0A0D8XBL4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="13562" checksum="0EADD6541EB49E08" modified="2015-05-27" version="1">MGGGGRTVTTAVNGGGKANVPTVLRVVVVGGGGVGKSALTIQFIQQYFVQDYDPTIEDSYTKQCFVDEDLCKMEVLDTAGQEEFCTMREQYLRSGNGFLIVFAVTDRNRCVHFIDLHKTIISCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBQ1</accession>
    <name>A0A0D8XBQ1_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716723">
        <property type="protein sequence ID" value="KJH42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="29362" checksum="B9A67F110C809F4C" modified="2015-05-27" version="1">MHYLQNVNNLVETLTYSNAVIQESKAQSIPVTPENMSRREREIARRNKSFIDPAALRVAFKIDPSVLNDSLDSSIADIKKPIALSRCTRRIRTGNVKPNLNRGTLFRGITISSSTTAYTTTPFEVKEHLDGENTPSMEINTDGECMQKEPSVETKNTVSSSLLCPAEMTANLSRRRRFRLDKKAVTNHFDQSDKDNEGYSTEIAESNQQSLAVQHEAVQSEVPLIADICESSQITNTRLKRGRRSSIKPCLPSSDKSRKSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCZ3</accession>
    <name>A0A0D8XCZ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716661">
        <property type="protein sequence ID" value="KJH42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="186"/>
        </location>
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        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="30161" checksum="616B69F493481F93" modified="2015-05-27" version="1">MDEKLREQEHESRQRTAVIRSVTVATFALATCMIALPVVFTRLQELDSNVRNELDECMIESRNILRQVISAKVEFPLFSAANVILRNKRQASGGCCTCHRGSPGPPGPAGADGADGIDGIAGELGNPGPNAIEPLDYRKSKVVQCPCDAPAGPPGPIGQRGMPAVPGEPGIAGAPGQPGEQGEAGPPGKPGTQGERGQPGMRGRDGVIKVGEPGLPGPPGPQGDKGIDGERGAPGPKGNTGPQGPPGEPGPIARIGAPGLQGPPGNPGEQGPQGRRGPCDHCPPPRTAPGYFYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDS6</accession>
    <name>A0A0D8XDS6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716737">
        <property type="protein sequence ID" value="KJH41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDW6</accession>
    <name>A0A0D8XDW6_DICVI</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="402" mass="46877" checksum="B99DFCDBE207C497" modified="2015-05-27" version="1">MSDEEEYSEEEEVEEDGLEEPEEEQEKMEEELPVEEEKPKSRAPPHDDKPPAEMTEAEAAMLAAKKRHEEEEALKMLDYEQRRLVEKQKIEEELRELKEKQEKRRLEREEDERQFAERRRQDEERRRKEEDERKAKADAEKNRKNEERLRRQQMMAGSFAATNAVPGAGKNFTVTKSDQAAQFGNLTQAKSKDVLTKEQQEEVKRAFLASVCRAVDISSLLPNDLKNRIRDLHSRISKLEAEKYDLEKRHERQEYDVKELNERQRQVARNKALQRGLDPEEAASSRHPPKVTTASKFDRQTDRRSYGDRRFMFEHPATPKPPTIAHGTARPPSDWGRKDNEELEQLRKNLEPPKYVEQVKAEGDAAKPPVEPIPLQLPDKDFEDESAQCAETKGIGEEITVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEK2</accession>
    <name>A0A0D8XEK2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716595">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
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        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="223" mass="25445" checksum="86C41A547FF4858A" modified="2015-05-27" version="1">MQLSHIIPLLKALYERISTRSATNVKPWLLWIQCILSLHASYLSSVKNLETQLGGLLEWMRVRIGHQQKLLELYGKLSMLGEQIERRINRTVIVAPQPLMVFNDDVSDLEDVESGGSDESCVSSDDEQQEWWDENGFGVNNDCRDDEDSDGLFTHLCHFTFQIHIKERKKFFEESGSDSDSNVLMSKVNNDGDNCVVNDDNELEKELSADGDDEENEDEMDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEV5</accession>
    <name>A0A0D8XEV5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716696">
        <property type="protein sequence ID" value="KJH42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEV5"/>
    <dbReference type="STRING" id="29172.A0A0D8XEV5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26839" checksum="92A37262ACE783B0" modified="2015-05-27" version="1">MEFNIVDDDYCPLFHYQYRMILIGDSTVGKSSLLKYFTDGKTAEMSDPTIGVDFYARMIELKPDYRVKLQLWDTAGQEKFRSITRSYYRNSVGVMLVYDISNRTSFENIGIWLNEAEKGVGGPNPRKVVYLLVGHKSDDQSDRQVGFFFKVDYEEGEYFAKYHKMKFIETSAITGKNIFDAFLMMAQEISNRVEKGLLRPTDGWEGIKSGMTRSQTITLSEINVPYKGQMCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF51</accession>
    <name>A0A0D8XF51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).</text>
    </comment>
    <dbReference type="EMBL" id="KN716680">
        <property type="protein sequence ID" value="KJH42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF51"/>
    <dbReference type="STRING" id="29172.A0A0D8XF51"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002119">
        <property type="term" value="P:nematode larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10552" checksum="27D017A82D821B5A" modified="2015-05-27" version="1">MSKATKKKSSKKRSGTETTQFDQKTINEFKEAFGIMDQNKDGIIDKNDLKDLYATMGQIASDKQIEDMIKEAPGPINFTVFLTLFGERLTGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFT4</accession>
    <name>A0A0D8XFT4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_11445</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716650">
        <property type="protein sequence ID" value="KJH42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFT4"/>
    <dbReference type="STRING" id="29172.A0A0D8XFT4"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25430" checksum="3658ACC9D6938421" modified="2015-05-27" version="1">MAHTEYRQVQATSLTEILSDIGGNMGMFLGMSLITVTEITLFMSKIGWIAFSKRRRNYLYNKQKREKEREKQLEETVSGFNMFRSSKIDGVGDSFRVTQSRIRSLGKQIRDSFRHSKPKRVSAPPSYSLNDVEKAKQQTVNSEKKPKSLPISNCDVTDKAFNINGTMLRKQENSMIELQINLHDLRQRMLRGLPIIVRSRQRASTAPPTPRGVHVNPRKTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGB1</accession>
    <name>A0A0D8XGB1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">aECM cysteine-cradle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716829">
        <property type="protein sequence ID" value="KJH41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGB1"/>
    <dbReference type="STRING" id="29172.A0A0D8XGB1"/>
    <dbReference type="OrthoDB" id="5861617at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055352">
        <property type="entry name" value="CCD_aECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435:SF4">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37435">
        <property type="entry name" value="PROTEIN CBG14344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23626">
        <property type="entry name" value="CCD_aECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="aECM cysteine-cradle" evidence="1">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25055" checksum="855905457E7D3533" modified="2015-05-27" version="1" fragment="single">PTQFSYYLDFIVDEANSVREKYQANRNSLRRKDPNSGSCSKSSAFHSGHMKLFHVVFSAGIIFSCEGLRRVYVKSISHSLPIFQRLQEEDSASSLTEHAQTTNKIYEVLELDHKTFQESGNGATIIDEKKKALEGEISVSSTTEAVMTFEPIYDKPSDVSYSEHELLQLCNDAKNTGKKFGISDMTSFADNNCSLIQLYYTDVTCEQINTFMQYCQSTGAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGL3</accession>
    <name>A0A0D8XGL3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716808">
        <property type="protein sequence ID" value="KJH41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGL3"/>
    <dbReference type="STRING" id="29172.A0A0D8XGL3"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000053">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="22896" checksum="11993B9080DF9073" modified="2015-05-27" version="1">MINSYRCECESMYRGKYCEEKLQYCSKQLNPCQNGAKCERTENGYKCDCMPGFMDRNCSTNIDDCTNHKCQNNGICVVGRYSTSLNKVVKDGIESYSCKCVMGFSGEFCDIPPTFGATYPNTAQCYSSSCTHGSCYMNDQTKEYECRCHEGYGGKKCDELRSIGFTHPSAYVALEQWQVENGNLTFTIRTTNKLVFFNLVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM5</accession>
    <name>A0A0D8XHM5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716581">
        <property type="protein sequence ID" value="KJH43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHM5"/>
    <dbReference type="STRING" id="29172.A0A0D8XHM5"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056879">
        <property type="entry name" value="RM3_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25065">
        <property type="entry name" value="RM3_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="8">
        <location>
            <begin position="112"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM3" evidence="9">
        <location>
            <begin position="477"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="54791" checksum="F4DD23D10A8B10CC" modified="2015-05-27" version="1">MSTKPPSNNGENKRQVPTVALPKEPKEKKGILRSLSFQFSNLGKKKDNHYDMTPEEMNVEEMGPILGVQCYGNLMKKYKKRNRPAKWSKRFFILKECFLIYYSTSFKKKFQKTKKIGLHPKGIIPLIGCSIVCGGDVGKKHCLLIAHPQFPSAIIVAAQDFKTQEEWLKALRNATKISFKNTLVGETMIRELESRGVMLCEEKKTYEEKLEQEAKARKEEHDRAAELAKMKTELENEREKLIRTTKKLKDDLQNVKNELKVMNETKITLEQEKISLNSKNEHLQANMESLNIEKEKTEEQLHNILREREQFLLENQNLSTTTCQLKNRLAEIETKTNCIQVEKEKIEMLLHLNENKTMDLEKERQYYTNQTKELLQSLKNINEQKELTESELREQVIARIGAEKQLQAAEKALEHLEMALKMTGAQMTELQEHIMPDVHKLREYFEQCAHEAQLEANRTGIMRQAIYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJT8</accession>
    <name>A0A0D8XJT8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716444">
        <property type="protein sequence ID" value="KJH44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJT8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJT8"/>
    <dbReference type="OrthoDB" id="10070774at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="340" mass="39129" checksum="589CDE24FDFE733F" modified="2015-05-27" version="1">MPDRGRERERKRRRRRSFDEDDNGFSGWKLGLVVGVIVVCFAMLYPTVLHPMLMSFFGRSEPAKAPRPSRPPVHPGMGGPGGGRTGGRHDVHPAMKMAQQQAESHSSGRGMFTWMLPLYTIGVVIFLLYTLFKSKNRRKRRSRYDSSEFSSDEDEYNDRLTKRLVDRLGKKKLRGLQERLQQTEEAMTKILEQLEAVQAAGALIEGEQGLKGRKDDPEKSELLPQVDAKNEQYINDLEKALKDFKVLSEAYEEEKSMIRRKSRSEEDETSSEELHSESSEDVEEPEEKTKEQTKIELVDESEEEYFSKENETKSLIDKECVENESAKPIAKNVRRRAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV0</accession>
    <name>A0A0D8XJV0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XJV0"/>
    <dbReference type="OrthoDB" id="10027016at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="30777" checksum="8D5156127163F5E2" modified="2015-05-27" version="1">MKNLFRSPVVEESRRSLPSIIEVNVNPKEVWEIIGELGDGAFGKVEKAVSKTDRNLLAAAKAIEVQEGELLEDFLVEIDILTSCKHINVVKLYACYFFENKLHMMLEFCGGGAVDAIMIELEKPLTEKQIAYVARYTCEAIAFLHEQNVIHRDLKAGNILLTSDGVVKLADFGVSAKLKDCNEKRDTFIGTPYWYVIKNPAERKTAKQMLSHSFIANASDRRPILALLAEVNADIEEEVVMDDDHVSCDESCADSEDQGKKQAICFETYKYVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLB6</accession>
    <name>A0A0D8XLB6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferlin B-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF08150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0D8XLS3</accession>
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        <name type="common">Bovine lungworm</name>
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            </authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    </dbReference>
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            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50112"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="97" mass="10902" checksum="7F1FA6AAFFD47664" modified="2015-05-27" version="1">MEDHQVHLDQQQFSDHHTSFILANAQVVDYPIVYCNDGFSKLVGYSRAEIMQKPCSYGCVEKKYTVLLLGGFPSVEKPKVINFSKTLIESTIGASME</sequence>
</entry>
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    <accession>A0A0D8XLU7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716451">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KJH44754.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="79" mass="9360" checksum="D597A03BBB568FAD" modified="2015-05-27" version="1">MLDSFVVARRIRFQNFMKLVIVTQYGHITKKGGVRVKLELVFRRTKDCLFINVTYNNGCVERQLFDLCRITNFLSERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM11</accession>
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    <protein>
        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716445">
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        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="20570" checksum="0D0D2865EA6D7D26" modified="2015-05-27" version="1">MSRTCATLFRKADGFMRHVMRCDSSRAGDVDSEPDKRTILISPTNVDITTKTSRIIPVRKPLANGLTPTPSMHSSTVLKQDYNLKETIVKMQTVPSTRMLEIGSENEVKNSPLLKRAQNRVTTQKSIPRKVQKMDTSETNDVSANTTSTSTTTSNIGLKDISSEIRPSRMRKTPKWLEDNAFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM59</accession>
    <name>A0A0D8XM59_DICVI</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716556">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14562" checksum="66A4C452A259BAA3" modified="2015-05-27" version="1">MDGIVCNLSLSSTRLMRSSSNRNKALHSHKDWMTSEYGNSFPKWVPPEIIAAYSDKNIEKLFDWQTNVLEIAEKCSDNVVYSAPTSAGKSIVAELIALRVAMTGKKVLFLLPYISMARERMNFLQVVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMR1</accession>
    <name>A0A0D8XMR1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase, patatin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716385">
        <property type="protein sequence ID" value="KJH45810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XMR1"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07204">
        <property type="entry name" value="Pat_PNPLA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="605" mass="68273" checksum="90AA00192DFBB5DF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMR2</accession>
    <name>A0A0D8XMR2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716379">
        <property type="protein sequence ID" value="KJH45918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMR2"/>
    <dbReference type="OrthoDB" id="5811893at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33853" checksum="D2F5332BCEC23EB9" modified="2015-05-27" version="1">MVSEKTKNGTLLWFPLPITVGGHLPHQQRVRFVPVSSTVGYPIKIINKQNLIGRRFAEIQLSGHLSANNLDLMEFYLSAIDDYGFEYAKCKVTILIEEASYEPPKFDASHYFTILPKIPADYVVMTVKARDRRSTVLYHMKHDNSSFDVLPFSGEIYTTSATFPGKYTFDVVAENSIGQKSSTTVTVIIQDEKSITNAILDGHRRRIRREFSEAVVIKLKENTIGQYKKLIPLYVGEKILDAPVVREHFTVFPDGSVKISKPFNYEKIHELTHMLHVVGPREYDHHVDGGDVRRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMY2</accession>
    <name>A0A0D8XMY2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716532">
        <property type="protein sequence ID" value="KJH43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMY2"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335786" description="TauD/TfdA-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21935" checksum="9871126C582FC3C6" modified="2015-05-27" version="1">MYIGPTVSLSALSLMIFNSVVCQRIVRERFQWRQRIATLIVGSRITSIKNKNDTVELWKDDVISEYDTNYIVIDSKLSSSSSLKGYIREGKRLTSEEIHILYFCMKTFAYMFIKYGMIIVDNVEATYTTEMFCRAIAPIHDTFLGTCWVFRNETKEKAETSHEDTAYRNEFIGPHTDSTYFKQTPGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN10</accession>
    <name>A0A0D8XN10_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <comment type="similarity">
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        </source>
    </evidence>
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        </source>
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    <sequence length="563" mass="62977" checksum="DF91B7FD2D45CAF2" modified="2015-05-27" version="1"> </sequence>
</entry>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH44706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="309" mass="36010" checksum="8E933310CAFC48E9" modified="2015-05-27" version="1">MLINLLINDIQFDNIFVSAERLNLYLNRQEGDVDPDEVIVDETLKKKKSRWKRYEKPFEEHLRNETAHRVHLLKQRIIDDLWKMNKNGTSYNIWVERAQTAMDDIIRDVFIDYTRNYMTPEDVITGSGPFKWSFGSSVFFSWTAITTIGYGHIVPRTNAGRVAIIFYALFGIPLILVTIADMGRFLSGGIIWVHNTYRKFMDSCYAQCWKCIKCTCCRFRRKQRRIQMPTIELLQKQGQVYGTVRGPRKTHDNRSDAGTFEDISEIHTQNSQHGGDSEDTRALAEELEPEIPHHERRVSVTFILVIMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQW1</accession>
    <name>A0A0D8XQW1_DICVI</name>
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        <submittedName>
            <fullName evidence="6">RPEL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716366">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="393" mass="43784" checksum="40FE98584AA2A05F" modified="2015-05-27" version="1">MFVLNIEAELNIAFLFRSGSERSHKLTTTTHSQGCPTSPSLPNFRNVTQSIMVCEELPMNGNDASVCVESVSESNVGESASECPHALLSGVNTDSVTNIRIDDVPVLLFPTNTNSGDYNPVHCESQASGTSVESESYTDTVEASILEGYVGIEAKEPNLAAQPNKPVLRKPGQPSRLNIRKNQSNCSKNGVEFLRSDLPTHLTDDSDSDNPIEYRDSESYPRIPTTSSRSSDDDEEVPIGGLAAKVARRDTLALRLEAPPCKDDISGQTADDRRTLMHNASIKLARKLSERPSAEELENRNILRSPAVKTMEEKRKLLLRKLSFRPTIAQLKEQQIIQFNDYVEVTQAQAYDRKADKPWTRLTSMDKALIRKELNDFKATEMDVHEESRIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR95</accession>
    <name>A0A0D8XR95_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716440">
        <property type="protein sequence ID" value="KJH44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR95"/>
    <dbReference type="OrthoDB" id="5806770at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="192" mass="21909" checksum="942F5C9045F812A1" modified="2015-05-27" version="1">MEQGVAKSKGTHSRWSYPCDYQSRDPGQPKSVAAHNGAYRNNETHGRTVTVRKNTPSHRRRSFNPVETEAIMKLSMCFPFDTSMRLMNISIIAKCSSFYHRRHHLHVKSNRVIQASQKMSLLGSLIRGRLISYTALRNTCMNTDFAGMTGTLCCCNNRHYCNSSRPKIRLIPFLIPLLLIFGVFVQIMLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRD1</accession>
    <name>A0A0D8XRD1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KN716317">
        <property type="protein sequence ID" value="KJH47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRD1"/>
    <dbReference type="STRING" id="29172.A0A0D8XRD1"/>
    <dbReference type="ESTHER" id="dicvi-a0a0d8xrd1">
        <property type="family name" value="Carb_B_Nematoda"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043187">
        <property type="entry name" value="CM06B1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45029:SF6">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45029">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="191"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="576" mass="66022" checksum="D5417D4D6C16E487" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSA9</accession>
    <name>A0A0D8XSA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716303">
        <property type="protein sequence ID" value="KJH47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSA9"/>
    <dbReference type="OrthoDB" id="5869556at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="391" mass="44153" checksum="C92678C20DE7B3F2" modified="2015-05-27" version="1">MDADENLAGDDQQQGELNYFDHYSHLLQYPCIKQAVATYDWTKHRSRLLESALNRIEAGVFTVVNTAAKKILEVHRNCYVRPKEIVASVYNTGIEKTKAVVETSTDFAVRGGTFGLGAAVVATQVSLTLSTGCALLILNTIEEARKAGLSMLCAIRNAEQLIEQKIWHAVNEGIRVAKVPAAKLAESTNVFLDVVSVLVERSFGIVVEDNVECSVKQRVTVLAQKIVEAINDKARSKVIEPFSNHVRFLIDQLSKKFALVDLILSKHEWVLGKVIELSSSIHDMKIRIENEAIECRTRPEEVLMKSIRSISSKLKDNLQALKDKQIFGDGTKLESLINYLQEIDKNLGESNDIYEVRNEVYELIIHFLRYWCTIKKCDSVNCKKRMLKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSX6</accession>
    <name>A0A0D8XSX6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPI-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSX6"/>
    <dbReference type="STRING" id="29172.A0A0D8XSX6"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
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        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
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    <keyword evidence="1" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="3">
        <location>
            <begin position="770"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="898" mass="99699" checksum="BE3CBD3F87669A8E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTI5</accession>
    <name>A0A0D8XTI5_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Immunoglobulin I-set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XTI5"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bent, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        </location>
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        </location>
    </feature>
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            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="400" mass="45047" checksum="44978641A0F4EE99" modified="2015-05-27" version="1">MKRGRQCCNVSGIAAESRPIALDFTQIYWCLSIEQLDCFAETMPEGKAPHFPQQPVARQNDDGSLELECFLDASPQPDIKWFYDNKEVKQDSRFQFKLDSKGNDSYSAILQIKDLADSDAGGYRCAIVNPHGKGNANFNLKLTGFSSPTFVEKPQISSRDDGQVMVMEFRAKSILKPTFVWHKGDEIVAQSDRVNIVLREEANQIYYAALEIKEPTKEKDAGQFICTAKNDSGKLTATFTVKFEVPQGAPTFTRKPQILQVTSDSGDPAIVFDIGYQADRNPEVSFFSTNHLICFFFFKQISSFFRFSMFKQIPWNLLFKVMWINPKGKKMKESTRIRFFTSPDGPNNTFTAKLELKNYKAKDSGTYTCNIKNEAGEANVELTLNIEGPMDDGGDDGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTJ4</accession>
    <name>A0A0D8XTJ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase RFWD3-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716291">
        <property type="protein sequence ID" value="KJH47830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTJ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XTJ4"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RFWD3-like WD40" evidence="1">
        <location>
            <begin position="120"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="446" mass="50161" checksum="4AB216876B7DAABB" modified="2015-05-27" version="1">MKDVRKHYTIAVKVTDTTEVEQLRNANAALHIRVSGLEVELARKDREIYELSNKLQGDNARFVFRVPCIQTYLSKSSLDYSKTSLVFSNNEANPNKLFVQPRGGRIYMNPERKDSLMIGSANADARAIDFNGEFWAIGVACSQARNIFSPFGIRMVTLTQHDFKLHECYPLHSARPRVVAFSPFESSLLLSGGEDKRAIISINGTIRCQWKMPNEKPVWTGCWTAPDKVALGLCDGRVFEYDLNSGSTEPVRDYTQGVGHLPIIFTGFDTSSSALLVASFKTLIAFRNEKVFPLLSNVTDEFDKMRSISFHEASLHFVITLSPGGRHPAISHRLYRLEVDGENDEVHCIEMAQWLTDCQMSSTMWSNCLFSLNNGLYSVVYNEDKQRFDAHDWSGRRPDAMVNFPSRSTVTAIRAVATNCDSRKTIVVLSDKAIFSLSFGLSDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU56</accession>
    <name>A0A0D8XU56_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CTD nuclear envelope phosphatase 1 homolog</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine/threonine-protein phosphatase dullard homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Dullard family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU56"/>
    <dbReference type="STRING" id="29172.A0A0D8XU56"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044091">
        <property type="term" value="P:membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000044">
        <property type="entry name" value="CTD nuclear envelope phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="75"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="30220" checksum="5530A0463CC8BCD0" modified="2015-05-27" version="1">MRRQTSSSSSDRRVHQPNSHFRNMMSMITAVLIAIGAILSFLMQGLKRLHRGYAKYQVVKYHHVPCSPLTAHRLSIMRKKILVLDLDETLIHSHHDGVIRPMVKPGTPSDFTIKVVIDRHPVRFSVHARPHVDYFLSVVSQWFDLVVFTASMEVYGTHVADKLDNGRGILNRRYFRQHCTMDYGGYTKDLSAIHQDLSSIFILDNSPGAYRKFPQNAIPIPSWFSDPSDTCLLNLLPFLDALRFTSDVRSILSRNQQSFNQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUQ6</accession>
    <name>A0A0D8XUQ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homoserine dehydrogenase, NAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUQ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XUQ6"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873:SF6">
        <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873">
        <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20390" checksum="8054F501CC47D205" modified="2015-05-27" version="1">MMKKQRVGVIGYGHLGEFLVSELNRLDDFQVIRIWNRTPNNERGILPLEAITVQHLRDIDLIVEVAHPAIIFQYVDVILDNCDLFVKEVTSILLIDIFLITTVILVINACQVSESYSRRRFSYKFTTSKSSNTQLLENGAKADPNDGKSWPYILPMCSIFIACHSFSFLLYFENILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUV1</accession>
    <name>A0A0D8XUV1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716300">
        <property type="protein sequence ID" value="KJH47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUV1"/>
    <dbReference type="STRING" id="29172.A0A0D8XUV1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="116"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="29273" checksum="1F6292963C222D99" modified="2015-05-27" version="1">MATNDQHVFMVTDPKMLKDAPPHVLQKLAVEPTQWEEGPWRGRMTPHTLYPFIQYCENRQLRAEAWEKWTNKRRSTGLDESFSILANISQIDRYHSAHTWLRVREVIFLVTVGSDARGLDKLVYLIGSAIAPTQALPSLLHHQQLQQLLFHVGRALQMLLSRSPYRDIAIPWAPFYASDWDAADAFPTFLQFFVYKPTLLQSLGSPHVVNGTTISDDAANNICLALSRATLWDSYRTLFWSDLDLTIFEMEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVI1</accession>
    <name>A0A0D8XVI1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    <sequence length="350" mass="39857" checksum="272B0CD9B12560ED" modified="2015-05-27" version="1">MIPKIKRTSTGKTLLPLEETLRNRWYIKGLIGHGGYGEIYYAVDIRNSDEVAIKVEPKKRKGRLVKRMILEQKVLLRLQGRPHVPKMIASGNDEKINFIVMQLLSVNIGDLKKQSPVKRLGRSSVGRIMQQAIAGLRDVHLCGYIHRDVKPANMCFGISPQTRHILVIVDFGLVRRYKNMDGTIRPLRSRAGFRGTVRYVSIRVHERIDQGPADDLVSLVYSGLELLIGDLPWKYIVKGDDVKRAKQELQSGPPHTSFLSLTTESFQEFARAVFSLNTEEEPNYSALQALLTELVGDRKMSDPYDWEMNYVEAVEGVRIFYTYPQKLLDISESTETASNKSIELDNDIRL</sequence>
</entry>
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    <accession>A0A0D8XVU4</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
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        </location>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH48733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147440" checksum="54E91FDFF9712C80" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVX5</accession>
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    <organism evidence="12 13">
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="205" mass="23713" checksum="51DACFC0EF86687B" modified="2015-05-27" version="1">MFYNSSLLLRHPNDVRDQLYDIEQKLRLFKSYQKKVFAKYFENLDEANSNTRELRPSRKLMINSCFRDAAYITVQWINSTITVLDRLVWLGLIGEQFDTSGSRENFQHALGLFLTRTVNAIQSGIIKKIMKPISNFNCLENLNQFTAACRSLGVKDEETFQSVDLFDGRDLFSVCVTLQSLARKVEKTHNITPPKQISKDSIMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYC8</accession>
    <name>A0A0D8XYC8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYC8"/>
    <dbReference type="OrthoDB" id="5862630at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13378" checksum="0A05800DA145A6A2" modified="2015-05-27" version="1">MLTRLYRLPALVLQPDIVVRVGRGLVKEANYHPRYSQRFALTPGVQALKLSVVHESLPTLYYNIGVEVRAGTGRYKDTQVVLLTSRYVINNNSSFSIFACHHDLIDLSKTMNTKSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYR8</accession>
    <name>A0A0D8XYR8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYR8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9586" checksum="1D37A00798F0704A" modified="2015-05-27" version="1">MAVKLNTIEILDTNDWPVSPLAEGKAPSFKVPPTWRRRITVGEKPQSLLKKVLIKVTQQRTKCFKTENGTPSTLLAKPERPDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ72</accession>
    <name>A0A0D8XZ72_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716298">
        <property type="protein sequence ID" value="KJH47651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ72"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ72"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01416">
        <property type="entry name" value="SAICAR_synt_Ade5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000183">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000020">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050089">
        <property type="entry name" value="SAICAR_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599">
        <property type="entry name" value="MULTIFUNCTIONAL PROTEIN ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599:SF3">
        <property type="entry name" value="SI:DKEY-6E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="31371" checksum="F80A9B06CB15D661" modified="2015-05-27" version="1">MESLVADPANIAQIAEGKTKIIYSIRGHEDFVLIRSKDQLTAFNATRKNILEGKARIANKTTINVFKLLNSIGLATHFVEEAGINQFIAKSCKMIPIEWVARRIATGSFLKRNPGVPQGYRFDRPKIETFFKCYFHDDANDDPQYSDEQIECAKFEFNGVKIGKIEVNLMKRMTSVIFRVLEKCWSKKNCVLIDMKVEFGVTCDKQIVLADVIDNDSWRVWPHGDKRLQLDKQLYSFPVLKSSKRIFATLVLSTTKQALLLNFRFIFIDFSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZL8</accession>
    <name>A0A0D8XZL8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZL8"/>
    <dbReference type="STRING" id="29172.A0A0D8XZL8"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="627" mass="71924" checksum="1D955B7F530E0183" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZV5</accession>
    <name>A0A0D8XZV5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH50000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZV5"/>
    <dbReference type="OrthoDB" id="5801479at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF93">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40268" checksum="B4D737F748AB9615" modified="2015-05-27" version="1">MPSAYNGGYTHEPYGHNAYIDTTYGDTQQFPYYDAYTYTPLYHGNGQSCYNYAYQSSQAAYPGAYGPYPGASGAYRPYPQPQPSPPRRSRTTSSRLFQPSVRTNATPSRKLRGISADIYDKRQFKSFSGPLKKPSPIYRRCREPHAYRLGPYQETEFGGAPVDYSSHIGRSNEAPTTLRRLRPFYAPSYATYPPSTMLRTEKKLDARKYPIFARVTMKIAQLIIAAVILGLVLGPMHGTSFHDFIIRTNTEWQGVVVGIVSTWGILTLLLLLTSFVANTIHLWRKLDAHVTLIGILAYLLASCLEAYYAACYPPNGRRINLVCYRTEWIIATILCFINTALFVIDFAMSWISGVDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0I6</accession>
    <name>A0A0D8Y0I6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_03453</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716207">
        <property type="protein sequence ID" value="KJH50373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0I6"/>
    <dbReference type="OrthoDB" id="5786116at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF793">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11 13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005115628" description="Zinc metalloproteinase" evidence="11 13">
        <location>
            <begin position="17"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="137"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="354"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH50373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="472" mass="53363" checksum="C68AB94F01C1B8D3" modified="2015-05-27" version="1">MKILLFLVLYITTVLSNTATWNIRPSDHNETVEEKIERGYQILKDEAHAADTKAFLLKLHDVEQGRETELDQQHANLPDDMKRYLNINFDEVKQMGDTIVAVNEKSHVEMALYQGDIMLTKEQGEQIINDIEQNDKNRLKRQAYHPMTFPMRLWSDGVSYTFHNASGGARKVFRRAVEIWQNVTCINFTENSTAVDKIIVVNSSGCWSELGKLGGDQVLSLGNGSKIPRRWISFEDDWKSQLIKESNITNYNYGLTYDYGSVMHYGARTASKNYRFTMIPQNDVEYVLTLGSDILAFYDMMMMNLHYGCLDRCGGVSSSKCANGGIPHPRNCSKCLCPSGYAGDLCTERPSTGCGATLIANFTEQTLTVTMGDRMSRILKDEFDLCHYWLQGPKNSRIRVVIDGYWGITAGGCKYGGVEIKTGEDKRYTGYRICSNDFAGVILTSTHNTVPVIVFNRYHSNTVTLRYQIGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0V5</accession>
    <name>A0A0D8Y0V5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0V5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0V5"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="264"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="451" mass="52032" checksum="C515F1A3A7D629C0" modified="2015-05-27" version="1">MSRKKKHGGHGHSHDEGGCCNHNQDVSLHGEGSSDQNSVGHDADMQQHKNFAFWSTQPVPQFDDEKVEDENTYIEPDVPLDKVLVSNMYTFLWKCFVVLQIRPEPYSLPESFVWSDVDLNNEKQLQELYTLLTENYVEDDDNMFRFDYSSAFLKWAVQMPGWLPQWHCGVRAKHSGRLLAFIAAVPQKIRVYDKERPMVEINFLCVHKKLRSKRVAPVLIREITRRVNQQKIFQAVYTAGVVIPRPVGICRYWHRSLNPKKLIDVRFSHLSAKMTMARTIKLYRLPETPATSGLRPLGKKDVPSAWKLLSEYLKQFSLAPVFTKEEFEHVFTPIDGVVYTYVVEVGGKVTDMLSFYSLPSSVMHHPTHKSIRAVYSFYNVATTVPFKQLMNDALIFAQKLGFDVFNALDLMENASILEELKFGIGDGNLQYYLYNWRCPEMKPEQIGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Y3</accession>
    <name>A0A0D8Y0Y3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0Y3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0Y3"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008545">
        <property type="term" value="F:JUN kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF15">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="335" mass="38383" checksum="5D35D45FFC237445" modified="2015-05-27" version="1">MLDEGRLPLRPQLELSLAPPHDENILLSTLSTGILKFPEKEVGYAFTASNLIDCGKIGSGNFGSVYKMVHSESGKEIAVKKIRCNNISSREQEKIIREHDTIMRSEKCSKIVKYFGAILHEGDCWICMELMDISLDVLYKRIYNVHLTQFNENVIGHIAVSVIDAFYYLKSELKIIHRDVKPSNILVNRCGIVKLCDFGISGQLINSLAKTHDAGCQPYLSPERLSHYGQKYDIRSDIWSLGITLYEIATGEFPYPPWSSVFDQLSAVVQGDPPMLKMDGKFSRSFVTFVSKWFVILHYHFCKENSTNFFFQSLTKDYKDRPKYDALKNEDFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y104</accession>
    <name>A0A0D8Y104_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="37483" checksum="09E94A041673EF7B" modified="2015-05-27" version="1">MDKIIRRFCSLSVTEYRCDFCSFLRFDLYLVVYVVALLSSIPTIMINILILFVMRKYVSKLVGDFCKLCTHFNHNSRLNETNKPLRIVIFLTIADLLHAVAVFPYIIYLISKWDRTTINMNPYTIMISSAPLILHLKTNLVLTIFIALDRTLALYIPFRYRRISPSKFGNAALFIGIVIGVFDLIIEFKLSSFVEVPNCGAVGCFVSLSFRTYWGLSNMALSITAIILTILVMVKLHCLRINSNSLPKSQNCRNDKLFKASCSSLLFLLCSLLFLTTPSVVVAVTELFGVTFFRFIGPLNLAGLLSAGQQQLILFDYFTVRKKHNAESRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2W1</accession>
    <name>A0A0D8Y2W1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2W1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2W1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="270"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="457" mass="51400" checksum="4286D0F2919CD090" modified="2015-05-27" version="1">MDLTSDFDEVFIVALLAVANSDVSDLLPNACELNVLIVLDRSDSVKGGFNKSRQFVIDASDEMVIGPTHHRVAMIVYSGLSYRREVFPWNFAKSNEEFVRITNNLRAIGGTTNTKKALEVAIDVMAQRNKTIPTLIMVVTDGRSADDPKIPAQRLQQEPNTWVYAAATGDPEKVDKQELEDITGNPYHIVLHRGREHAADVARRLLRKAQLWSCNEASYHSVLSSNMHVRQELEDITGNPYHIVLHRGREHAADVARRLLRKAQVRCEMDLVLVFDFSTTTDPLIEYYKEMSKKLVQALRIGPHYTLVAAVTFATVGRTRTKFNLKRYKTQDEVMKAIDELESTGGTTAIGEGIREATKQISQKEGARPEIATKVMIIFTDGWVNKGPDPEEMKKVAIDQGFEIYAVSFVGPVPNMVHTNNEMLSVLAQDSMHIFTEKTFDQLIQKVKQRNLKCLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2W9</accession>
    <name>A0A0D8Y2W9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SLED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716208">
        <property type="protein sequence ID" value="KJH50364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2W9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2W9"/>
    <dbReference type="OrthoDB" id="5912862at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF138">
        <property type="entry name" value="POLYHOMEOTIC DISTAL, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="SLED" evidence="4">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="41838" checksum="A991B902682CC609" modified="2015-05-27" version="1">MLENSVEDKVKDLLMHAKVEQQRLAKQLLQPPVAYLSSSKIVHSPPPLPLSRLETSAASVAFYAPIKNEAEEVVSSTTAPVDTPHSNRSLIPHSLCSQGNRDQMKILKQVHPKIECEDRRKEKVEEALASSSTPISVHSGVNHQRSHDIELLSKDEIPLEERLMTIFVNYSCNLGPHLDPAMVAGIRRKFGPFATHHALREAVQQLLNCSIDDGLVLNLVQPAAVTQILSVTGHCGGIPRSRFIPCVKSSADAWNYLKQLLRKMKVCENFYSSTSDPCKNCMSGNDLSLEQIVASSQPIRHWTIEKVANELRKLLEPAVVLKFVEQQIDGRSLGLLTTDLLMTHMGLALGPALKVVDFVNSVRKAQEGQQLCSGSGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y340</accession>
    <name>A0A0D8Y340_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_03445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y340"/>
    <dbReference type="STRING" id="29172.A0A0D8Y340"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000040">
        <property type="entry name" value="Phosphoglucomutase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A0D8Y445</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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    </reference>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
    <sequence length="173" mass="19503" checksum="1577B9D3EDCA31BA" modified="2015-05-27" version="1">MKWGKKRDEPSAPREPEQAKDIREDTLGWIAQQIPPAVHKVNYFLLDWAQKLAYEESERPELPGKDGSMTRNQFLAHLRDGKLLVNLANKLQPGSISVESDVTTEAMVGTEAEKRTETVVEGEKKEEQATESVKIEEKKAATPQKTLKEKQSELINKFTTWANDCLGLGEGRL</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="558" mass="62484" checksum="026EF24BEE9CCECF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Y5</accession>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KN716228">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Y5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Y5"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="454" mass="50885" checksum="E368BABAAF69978A" modified="2015-05-27" version="1">MRFAQRLFRIAFFQHRNITVLGIESSCDDSAVAIVREDKKILSSRRFTDRDTQRRLGGISPREVALQHRTHLPLLLAECLDEAKLNFSDIDAIAATTKPGLVIALKEGIQKGLELSRQYKKDFISIHHMRAHALCAFLICDDLQFPFLSVLISGGHSLIALASSDEDFTVYGSPGECLDKIARELQLNQADEFRNIHPGAAIEQLARRCSDNGHLRYSVPGPRASGADMDFSALKSSCINYVRKERTVNHFLQKISVRVCNPSIPLVCLYSDTKLLIISTSSLDINSVNTLAYFLFFLGYRVTRHLVSKLHCCLEYLSDSGQLSLIKKLVISGGVAANDYICNGISKLAIFHGLDVVRVDSNLCTDNAEMVAWNGIMSLLNNSTNVHRYPQIPESIYVHDRFPIGRCSRSLVPSKPRRKLTLRTVHGDIPLKFFDRNFSKGEEDKSNKLVCENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y505</accession>
    <name>A0A0D8Y505_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y505"/>
    <dbReference type="STRING" id="29172.A0A0D8Y505"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="204" mass="23181" checksum="BF1BB126C895FEAE" modified="2015-05-27" version="1">MWQAPVLSEPAKEYVIKYRQKYSDSNAFKKRKVDPNLLSTTIDKLEPFQLYEFIIVTVGEFGEGLPSIPKEAQTAPAAPGRPPSKVQARSLSRDSVLIKWSPSEKPNGIITSYRIYYTNKDRSTPITQWEMVILNSFQFVVERNIKFAIQRDTNSDELMATLYGLEAETRYFIMVQAHNIKGASDLSSVVTVATKHGSQYSYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y551</accession>
    <name>A0A0D8Y551_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hyccin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH51998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y551"/>
    <dbReference type="STRING" id="29172.A0A0D8Y551"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44257" checksum="E072DC85915D057E" modified="2015-05-27" version="1">MNGEQLQDFLTDLSKTYIRLGSRDDLEVTKKFLDKWAHNTMLCANYITINYRDVDLVQPLVAQILALYYRGGILRQYALQFIPSFIGTYLYALSKKQQKSVAVFEVFFLAVYNEEILERGSELESLVKKTTVRVGPYPTIESFTSQSKFLILTRIMKSVNSSVVYMATDVVCRHVCLAAISISESGFSFPGTNFVCKVMDSEQSCEVIEDHSKKPRQQVNSNLLLELLTGVYMAFFNGAPDIAIRAIDAVHQRAQYEILAEVVLVTSAIRNSLLESPLSKEKRDELLCSRNSNMEKRRKGLVTTASLRIRKMPEDIPVQPELKEKEHPSLLEEGSQIFLTVTGMDNLKRRVSALGLHHRIHRNRKCSVEADDVTLLVFKLRMSLNFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5A3</accession>
    <name>A0A0D8Y5A3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716185">
        <property type="protein sequence ID" value="KJH51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5A3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5A3"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
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</entry>
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        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myosin heavy chain, isoform G"/>
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    </dbReference>
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        <property type="entry name" value="Myosin heavy chain, isoform J"/>
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    </dbReference>
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        <property type="entry name" value="Myosin heavy chain, muscle"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13374" checksum="A13638929F02FA75" modified="2015-05-27" version="1">MTILRRFQSSLEFRLHLRCEFLLLGMANAVAMIRSEASSLLRDHLDLFEMMRKEDEMVLCSGKSEDSGASSPVNFESASDIAEAVQSKLRSSPALPYFMSLLQHMLMVHIGILTAVNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5X3</accession>
    <name>A0A0D8Y5X3_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the COG4 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="COG4"/>
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        <property type="entry name" value="COG4_M"/>
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        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="11">
        <location>
            <begin position="116"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="54168" checksum="921780D1571E32E9" modified="2015-05-27" version="1">MAVSRLNNAMLVVEGDSKQLASSLRTISRLADNISSKVSALDVAKTRVVECLQLAGDMYDLGVCSEGVHDCISNEDYEQAAQHIHRFLTLDRAVFQFSSTAEKEAGQNMSHSYEVLTDAATRLKGILERKLDEAIDNEDVAAIQRFVKLFPQINEHDKGLLQFGKFLSKKILKIGEDNLKIMNAGGTDDKRMNVLYADTLYLFFEGIAALLETNQPIVENSYGADKLLDFINILQVEIDKIVEKVIDAFAKKRQLDKRLKVVQRILRDDRHVDKVVVEKIDALELDTLLSEICLMNTHTEMYWRFVRRRIKGATIESETEDSVMARCDDFGDLDEEKKKRFREEKLRRKEEREKKLDHLLNRSLVGSKMQFLGAPSSVVDDVLFLVRKCVRRAMSSGSVDCVCAALNNGVALLETTFYQHLYTAVQVCLIFPLQIAFLFYFYISFANNVNYIRLVTHRLILPLKLFKQLKMRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y627</accession>
    <name>A0A0D8Y627_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y627"/>
    <dbReference type="STRING" id="29172.A0A0D8Y627"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="461" mass="52473" checksum="FCDDC77A29CDC288" modified="2015-05-27" version="1">MAGIKVGRRLDRLQLFRILSYSQGSGSIHLALSLNLVVIQTTHSRIFAGRSPPSIASSKYSYNSKSQITSPNRTLLNISNLRATTTRSDRNIPLESKSSSTRTGISSQTSESNDESSHGSYTISRSESGRTSGGISQEDDNVYENSSNSKPSNNDQTDSKGSDENSQESLYWVPMPKDRYERSSRNHKQEFSNRYGFQQSQRRSRWDEYQASKLSSTHRLQRPKSVSVEHRGDPTLIDNDKEFMKLKRNKSQQKEWNKRFPEGTIVVYTDGSCIDNRASGFGVYFGPNHELNRSEKIIGPVHNSGLAEILAAQTALQSLRDWDRYRNEPVILRTDYLPLVRAMDSGICDRFSAEMEKVRALAMEFPNGVRFQHVYAHDGDPGNEQADALARIATESARRSRSASIPRFRNSMTRSRRSRRSRSRGRIRSRSASREFNRSRSRNNDPHHIRSHSAFVLGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6F5</accession>
    <name>A0A0D8Y6F5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ground-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6F5"/>
    <dbReference type="OrthoDB" id="5825670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007284">
        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336375" evidence="2">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="3">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26005" checksum="331A6A39AE76F3B0" modified="2015-05-27" version="1">MIVSLLSLLLLVQYSEAFFIIGSACGCPPMHPMCPPQPRCALNGVITQQTQPISVPDELELRAAAFGIPIGQQQQNPTSNLEQFEKLVDRQEESETAVTNKPPEQEENKQLLVALDSKTEVRRAPASKFDQSKESEVLTDASETNSNTDDEDFTTPIPQATTKCNSQVLRKLMYESMTSNSSESKRKVNAAAEMKFGGNVDVICSRGHFSYVFASNLFCEVTKDLVTCIAFRQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6K7</accession>
    <name>A0A0D8Y6K7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716179">
        <property type="protein sequence ID" value="KJH51624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6K7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6K7"/>
    <dbReference type="OrthoDB" id="5841389at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="210" mass="23749" checksum="BC462A967F7E9672" modified="2015-05-27" version="1">MCDNWGKMETVQHDDDFEPEVHSLAPHPPPPPVEEDRSVSREAPTRSGKTMLNMESFSRELSAAEREEIQRREDLALTLDMFGEKPTTGDERPYSDIVTKDEFEDWGLKVGTFLASRHKAAHYGDMLNKLIQTVSEKLNASEIRTMSNYLKTIADSKKAADKVVKSTPGQKKAPKASLKVGKGSVKEMYADYNAVDDYDNYSDYDDNDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7G5</accession>
    <name>A0A0D8Y7G5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7G5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7G5"/>
    <dbReference type="OrthoDB" id="5845308at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012362055" description="C6 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13709" checksum="A0A15EC93E6AB5B8" modified="2015-05-27" version="1">MHYCWLFMTISITSACAPPGFVQSNDPGMVGSRCSDLILYPVSAVDQSDQYRFDYSDVSFGNTHAQGATVAITCTTGGQPATVEGYDQQRTSISAAPSLLATCTNVGGSQYTWTILGRILQFVDCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7L4</accession>
    <name>A0A0D8Y7L4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7L4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7L4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="331" mass="37852" checksum="AA986EFF985B38BA" modified="2015-05-27" version="1">MTDSSNLVRLDNGKIVDGYKVIKKLGEGAFGAVYAVEDTMGRKAALKAESVNEKVPLLRLELIVMQRLKARNAVHMADLIDKGRFEHFNYIVMKLLGKSLQEAKKTGPNQHMSLGPAIGCSIQCLEALEELHWAGFLHRDVKPGNFAIGRAETGDIRRLYILDFGMCRKYVDNNNVMLQPRKKAPFRGTPRYAPIASHNGKEHCRRDDIESCKKNGTTANKAYMKTPLKQNVGSDHPYLMHQTLLKHHIRSDSCNASPNMVGKTKVNSRQEPLLSEMMKLCPRKEYKEVLDHIDSLQFFDEPNYELIYITLRRAMSRKSVKEFPYDWEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y863</accession>
    <name>A0A0D8Y863_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y863"/>
    <dbReference type="STRING" id="29172.A0A0D8Y863"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2 3">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="205" mass="23635" checksum="F5E89408AB57B848" modified="2015-05-27" version="1">MFTFRVNAVVFTYYTSIIVNVLQMLRYIMMLMVFKIAETVLKRNKPCLNGELDGNLCYCRDGWTGASCHRRMNCDGFERKPNGSCVMCSDGWTGPDCDAIHCNDRGSPNYDLTSCTCEKPYSGQFCETFITKDIYSYYNRIVSNFGAIGVLSCIPLIIIYVTCDRHAKRRHRERVERHLTGTMITHPEMVVNRQAIAHLLYDDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8G1</accession>
    <name>A0A0D8Y8G1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol-5-phosphate 4-kinase</fullName>
            <ecNumber evidence="11">2.7.1.149</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_00705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
        </reaction>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
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        <property type="entry name" value="GTP-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9065" checksum="27246FFB4E1DBFF3" modified="2015-05-27" version="1">MSLRFSSICFIGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGKQVIAGRFLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8Z7</accession>
    <name>A0A0D8Y8Z7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8Z7"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF7">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26348" checksum="78051F2CFDC5E815" modified="2015-05-27" version="1">MNSQWNISGLHGLVNNAGVLGSTFFDDFLSIDDYMKVADVNVWGTIRIVQAFKPLVKRAKGRIVTATSVCSRIAILGTGPYTVSKFALTGYCDIIRTELQLFGVSVHVLEPGFFSTHLTSRENVEKQLDTIYAKCSDEVKSEYGKEFFYKMRKKTMWLLGLASSTRIDLATQAYFHALTAVYPRARYQVGWDSILLYIPLTFLPTDLQDLFIRFVIKLIKIPKPLAARRIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9D8</accession>
    <name>A0A0D8Y9D8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9D8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14814" checksum="30D46B687CF946D9" modified="2015-05-27" version="1">MGESGKKTTSIIDRSVEVRCVVGRKCEKTGISRRLNDLSDLVPRIRMCQLRYATSTAYHFTNRIEDNTMAGQFPLDLFYIKIYKDNSMFTVLISVLHIGNQPVFLQPHEVLQHLQKKKEANDQRSLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Z1</accession>
    <name>A0A0D8Y9Z1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Z1"/>
    <dbReference type="OrthoDB" id="10678480at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="248" mass="28881" checksum="4596E685EB0F6D30" modified="2015-05-27" version="1">MNSDSIGDDFYIFAQLSRLEKLRLLLHYCNITNEDMQLWENLTNYNHHLFSNAFKIIMGTTLINTQSSENGVIVIRREYECISLKKRHFMKVFETLPNGRIALGTPESPFSHEFLLRHEEYLEKQALLSKHDFDSMMILAVVVVGCLHCHTVCWRPLLEDAVQRLILLPRSPAPLPSVFCNYVPESLDRVHGVDSLRYVQQFSQPQLPCTSRDLYNNCVYDLPSHFSEIYSTLQRCSQYEIDETVVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAH4</accession>
    <name>A0A0D8YAH4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAH4"/>
    <dbReference type="STRING" id="29172.A0A0D8YAH4"/>
    <dbReference type="OrthoDB" id="6777468at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="62"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="427" mass="48174" checksum="79D118111AC0FF6C" modified="2015-05-27" version="1">MSLPRLPIIAGQVAIAPSLVPPSNAPPSTIRVASFRSDDAATVQPKKLEVVSKQATKVTALSTKLEWKIDQFEKLMKLFKNGQNLISRQFGVPQAPTVCWELHVYPNGKREEDMNNVSFFLRQVGLQRGEEPIMTEFQIYALDVSSQRVSVCRDTKDFTNQQGRGKFQVSRDKMAGALRADGSLLLICEVEYFTPGSKISVEPADDEECTLEDVDEKVELSIRDSNREMWESELFTDCLIKVGNKEIKAHRCVLGQHSPVFRSMFNNESMVEAREGIIDILDAKYESVRAMVEFMYTGSMDTVDSNSVDEVLAIADKYEVLPLKEQCERLISITINQKNITSIAVFADTYTATLLKQAVIRYLTLHHKNIIRTPEWRAMKKDRYELANELLEAVLSASGDFDDDNLSSSTSKGPARKRVRRCVTTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBW4</accession>
    <name>A0A0D8YBW4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBW4"/>
    <dbReference type="STRING" id="29172.A0A0D8YBW4"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="99"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="802" mass="91769" checksum="D37949A56839624D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF28</accession>
    <name>A0A0D8YF28_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF28"/>
    <dbReference type="STRING" id="29172.A0A0D8YF28"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="21479" checksum="377AA8708D1B43F2" modified="2015-05-27" version="1">MVQSNIARKIGLIVAVDKNLGIGRNGSLPWSLKADMKHFVDCTTNTEDPSKINAVIMGRKCWESIPEKFRPLKNRLNIVVSRTLPECNDDDLIITNSFEKIVEELLYGQLSTKIERVWNIGGGEIYKLALQNGMVDQIIMTKIEKDFDADVFLDGIDWNHFQEDESARSDILNEKGLNFSFYTYNYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFP6</accession>
    <name>A0A0D8YFP6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00409</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFP6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16587" checksum="3D5DCEA25269BC68" modified="2015-05-27" version="1">MKCEVNMKDELIKNVSSESITAIVTPMAIRRYSRRQPDCSTAGFAEKLYSLNHTVESIEKGRRNKIISVEDCLFFNFFDECLSPPEDLSFMLDSTTWEALRSFRRVETIRAANRPTSPSQEVLRLTFDVMIVITLALQENDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YG83</accession>
    <name>A0A0D8YG83_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Activation-induced cytidine deaminase AID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YG83"/>
    <dbReference type="STRING" id="29172.A0A0D8YG83"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013158">
        <property type="entry name" value="AID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08210">
        <property type="entry name" value="APOBEC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activation-induced cytidine deaminase AID" evidence="1">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="319" mass="36579" checksum="C83937AE636D18AE" modified="2015-05-27" version="1">MRFSGNDYIYRSDFYHDSKGEPHVEEQLVANIYDLISKYNVELHEVVIFVSKSPCFHQDCDPKCEVVDECKSNKACAKLLGLLLSKIRKELKKVDVKMTVKFLYPHLNRGDLYTKQGILCMLQAGIKVEPLLMKDWCAIMDWSPNIDHKGDYLQLWNNHNLDKAVAQSQLFINECRRALGLSMKFWVAEIHEIVKNAILHFSELRVKCGDLNDALKQLDLTATPHKIKSTPSKRRSFIDLLELRDKLMRTSTEHKKNGSHMSVASEDAQAQAMVASFCGRSFDDCETDEIAQRIRRATANINVEIETLMEFLTHKGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5Q9</accession>
    <name>A0A0D8X5Q9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719684">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X5Q9"/>
    <dbReference type="OrthoDB" id="5850742at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24794" checksum="4CA1588669A3E1F7" modified="2015-05-27" version="1" fragment="single">MATLTSTVDDLLDWNRQSDLKKTQRTIAYVLRFLKKIISRIRENLRNRILHNIPELQSESPQQFISAIEYENALNLIVRNHQKMYCGSHVQKMHGCLRLFADDRNVIRCKGRLGKADIPQEAREPIFISSKTRLAELIVRDAHLPYHCSTCQTMANVRQRYWMSRLRNLSRKVIKRCVACQKMNNLPYRYPDMEDLPETRVQRTRPFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5Z0</accession>
    <name>A0A0D8X5Z0_DICVI</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718943">
        <property type="protein sequence ID" value="KJH39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5Z0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="9602" checksum="71C97815F1AC7924" modified="2015-05-27" version="1">MASVEKKNKIAENRVILMLPKIRHNSFDVRMETMKRVPALLSFHTEYETTYIHRYNVVAYIMRLIKFTLYHLFSKHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7G2</accession>
    <name>A0A0D8X7G2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721396">
        <property type="protein sequence ID" value="KJH39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7G2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="11839" checksum="3E5E9FAF47F7C736" modified="2015-05-27" version="1">MINRVRLATMSTRVVAVTLKALGVDLAGASVSLVRSRYRKGIGLIFPNVDTEIMIRMNHLRGNASELGERRSKTELENGLPGIGSAVGTDVISVKYRGFCDISCFLDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X831</accession>
    <name>A0A0D8X831_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_13328</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="EMBL" id="KN717041">
        <property type="protein sequence ID" value="KJH40710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X831"/>
    <dbReference type="STRING" id="29172.A0A0D8X831"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="18">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="17">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH40710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="28846" checksum="02CAD8BFE6F79E83" modified="2015-05-27" version="1">MKSFVPVPQDSDFPIQNCPYGVFSTKDNPRRRIGVAIGECILDLSEVAHFFDGPLLKSNQDVFKQETLNAFMALPRAAWIEARSTIQNLLSDDVNTLKGNPELRSRSLVNQKDATMHIPATIGDYTDFYSSIYHATNVGIMFRGKENALMPNWRWLPVGYHGRASSIVPSGTPIRRPRGQLKPEGTNVPSHGPSKLLDFELEMAFFVGGPATELGHPISIENTEEHIFGVVLMNDWSGKHFTSFTFSLYIYFVFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8F1</accession>
    <name>A0A0D8X8F1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719246">
        <property type="protein sequence ID" value="KJH39919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8F1"/>
    <dbReference type="STRING" id="29172.A0A0D8X8F1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001197">
        <property type="entry name" value="Putative ATP-binding cassette family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="10442" checksum="034D5F498D60B26A" modified="2015-05-27" version="1" fragment="single">RSQEEYRTALSHFGLVGDMALQSVYTLSGGQKSRLAFANIAMLKPNYLILDEPTNHLDVETVAALGMALNSFSGGVVLVSHDEQLTEMVCKELWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8Z2</accession>
    <name>A0A0D8X8Z2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20357" checksum="013C8C2EC9740E78" modified="2015-05-27" version="1">MAMCGKEMLSDNRILEGTSEIAKKLEMLDGDMEKLMREGKQLEVEMLFLITQNPSDWIKMPRTEEFVDIMCRFLNVLQESNALQFRWYEAFLNEIHLETEYSLRRIVTNDTQEGKSVEREKQLLNLLIYVIDEKARISEEIGDRTVDRSTVTKKELKRLKYKLQMALLSKKK</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20207" checksum="B1D747943EFCF8FC" modified="2015-05-27" version="1">MSSIAQKGLLALSIVFILAGLGLTIAGVFSPAWQVVDIREFRAEHQHGLWWDCIRAEKHVVAVGDFYDETPLHCMYKFDNSAELVIENTLNNIDEDGAAGESEHHRFWVLCSLIADGVFFLAANRVDNRFVQGMVGTYEQRIGYAFYLHVMGTICWVVAFVCAISTTYKFIYSRNSSNR</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF10">
        <property type="entry name" value="SHSP DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00011">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ACRYSTALLIN"/>
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        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="167"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="365" mass="43902" checksum="F59E5C104ADA9B1D" modified="2015-05-27" version="1">MCTLQFTSHLDRLDRNWRNDPFWQDIYPRWAEPIFKEGIDVHSNIINDERRFAVELDCYQFKPEEIQVKTQDDTLMIEGRHEDVRDRDNFTKMYFVRKYQMPRDIDHALISSNMDSRGRLTVEAPRRSAPLSGRDRVIPIEGAGHRSISSSQRVHESMYRSESHSPRSTEIPLHVQTGDSRSHEIHISRNGNRDLDSEREREREREREREREREREREREHEREREREIYVRREDDRDRDRIRDHEVRLSPHTSDYTSSSKYRYESHTREVSPHFVSSQNEIRSFMHPRRTSFETRSAGQESITEESRRERSRDFTSDRYHSESRNGYRVDSPSSMSGGILRNTDRPESRSESMRSVQILRKTFG</sequence>
</entry>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5912142at2759"/>
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    </dbReference>
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        <location>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="15706" checksum="5B481D30FB8E07D6" modified="2015-05-27" version="1">MLKFNSQLLLSPIQSQSFGMLLENDPAALVEALETIAAEQPIVARSIPKHAKITKHEDRSMRNCLFEQKVYDSMLFDSLRVCDLLQSHLDDCIVSVRAKSPEHCLDTSQDCKDSGRGASSPSLTGSSSPALKQSLKSCIRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF68</accession>
    <name>A0A0D8XF68_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BCL2-associated athanogene 6</fullName>
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    <gene>
        <name evidence="14" type="ORF">DICVIV_11630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <sequence length="183" mass="21623" checksum="E54047741519D1AC" modified="2015-05-27" version="1">MYAELLTTFISWKNFKDDDIRQMLLGARSLLHFQRRRVTIEREIGDFLENVVNRSLNIHYGEGWFLFFYFVSSNQIVFGARGSFTITCGNTGNLFLLPARNFQSQPSVNPFYRRQRLLRKVIRFHHKLSCKTQSYEFLNTHVVLLDCTTWHRSQDIGNFHVIILICAFKTTSLFLCFFDSCLE</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
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            <begin position="6"/>
            <end position="65"/>
        </location>
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        </location>
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        </location>
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            <end position="106"/>
        </location>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="7">HannoverDv2000</strain>
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    </evidence>
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        <source>
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            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="284" mass="32207" checksum="BF986E7C83E17AD7" modified="2015-05-27" version="1">MFNDDDFFGFGVHRNIQRQFREMDRMMNAMMDPFGMLGGMGMLEGPRGSPNRQMARPFDPFRGFGGLFSAMEDMQERAMNDPRSHVYSQSTMVSFGNDGQPRVIENSVRKSGDVKETRRSVRDGSREEVAIGHTIGDRTHIIEKKRDKDGKVRRQQRFVNLDEAAAEEFDREFQSRARANMNYNDTNARRALGDGSSTTGHRYQSANAAENLRTRDSAPIITLPEEDDEEEERSANSVRPSARVSRSAGGYTGPVIREISEEEAESSIPKRRRGFAGFFRANDE</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    <sequence length="641" mass="73407" checksum="E34F169A0C948DC9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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            <end position="108"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="127" mass="14208" checksum="0C4B7E6C8AA8C41E" modified="2015-05-27" version="1">MSSLCFSNISCVCYHNPTDYPFYICKTHSEQKRLKSADATWTPPNLAADDGSRPDLTSSGDPFVLSSVAAYITIGVLIVAILFTVMVLVVVNRQRQTRREDSPRHQENAQEALLMQPTDDDRYLPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHP7</accession>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntrophin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PDZ_sf"/>
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    </dbReference>
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        <property type="entry name" value="Syntrophin"/>
    </dbReference>
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        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
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        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="518" mass="58455" checksum="35135047548FE107" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI13</accession>
    <name>A0A0D8XI13_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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        <source>
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            <dbReference type="EMBL" id="KJH43584.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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</entry>
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    <accession>A0A0D8XJ11</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_09159</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716446">
        <property type="protein sequence ID" value="KJH44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJR8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJR8"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021939">
        <property type="entry name" value="KN_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12075">
        <property type="entry name" value="KN_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="76" mass="8423" checksum="2B3EE14A7ECB748B" modified="2015-05-27" version="1">MSTKQPLVTEKCSCCPYGFHIDIDFVAYAEDVRKGGQNRTPTTTRKHGGDRALLSPLDNIFSNILDPCKCINDCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLJ6</accession>
    <name>A0A0D8XLJ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_09353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC149 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716459">
        <property type="protein sequence ID" value="KJH44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLJ6"/>
    <dbReference type="OrthoDB" id="5917629at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019179">
        <property type="entry name" value="CC149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21682:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09789">
        <property type="entry name" value="CC149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="43742" checksum="1DB31974F740E13B" modified="2015-05-27" version="1">MNIEVYKKRQKTKAAKPLFYETSNCQRIVLNIALYSIKIQHLQSKVDSKTETIVKLGKNIESIQEENGHMKMRSLTLERNMERLEMEVYKYSTNEIDMKSKSQMEKQRLMDEVENLKKELAVVLKENKELKAEKIDLQNDCKLFRQRIAKYEISSLDNLSSTVGSDIITSRKEISNANNDELGKYEKLYNEFKQIETDLHTVLGIKEELVMERDVLVKKVERLNTEISYLLNGDPRRIVEDLDSLLAENRFLKARLDSANEESETMKATLSKYRSMTESRPSTENLVTGCETTLRQKSCVAVVNMKQIRELLSSHAIELDENDYKAITAILLDLCNDKQMALTHLRRANKVLGNRVSEVESHIAALEAKSQNANLNKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM06</accession>
    <name>A0A0D8XM06_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="KN716445">
        <property type="protein sequence ID" value="KJH44819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM06"/>
    <dbReference type="STRING" id="29172.A0A0D8XM06"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="234"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="476" mass="55877" checksum="824F17463A2DAC73" modified="2015-05-27" version="1">MLTNTRLSDVDHRFRFRNLGSQSKLRQLPGIAGQWMAKVSVRNNIVCANAKTAHNSKKRNTNFESILIFRSGKYIYKPLMERTCCPQYTIRLDVTKYILSRSHRKVLRQMNEYLKNDTKPRSNPRAQEAMCCEGSFPKSGVVKEATNRTDSLPKKKSDNPVPKKKEIRRQRCFSRWRDKGLDEDEMKKARVAKEKARVKTVESYILEPDKEWKHTLEVKLVSTSSKEFTERFEESFLLFKKYQEEIHSDNHVSRSGFRRFLVDTPLFDDKVSSSSERLSFGSYHLWYILDDKLLAVGVIDILPRCVSSKYMYYDPEYGFLNLGTYTALREIAFTRSLMKIQSEVKYYYMGYYIITCQKMRYKGFFRPSELLCDRTFQWVPLDRCQQLLQENDNKFTVFLPDLPPATMQTRDNLLLLVDGKIVQYSEIHDLGPALRDLANSEAIKENLDSFAMRIGCDMNRLVMYLPEFQNLKMAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMZ4</accession>
    <name>A0A0D8XMZ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716380">
        <property type="protein sequence ID" value="KJH45905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMZ4"/>
    <dbReference type="OrthoDB" id="5865705at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335788" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9517" checksum="072CCAEB6D298456" modified="2015-05-27" version="1">MVVVYLLITLLTLVKANNQTIVNVYRSCHKTVDDILDSKEAFIPSSSQLPKWCLAMRHDVASCIASEVMYLSHVNLNYSESNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPY9</accession>
    <name>A0A0D8XPY9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
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        <property type="entry name" value="ENaC"/>
    </dbReference>
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        <property type="entry name" value="Mec-4/10_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEGENERIN MEC-10"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Degenerin mec-4/10 cytosolic" evidence="15">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH47593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="278" mass="31460" checksum="0D1FD659A2DD9C8A" modified="2015-05-27" version="1" fragment="single">MKFNQNDLDEKANEKSGNSFPNISTYLASDTNFLKAAEIITTFAYGECSNDNDKEIQCDLLKEDGGLEIDPNRLDFKGRIRWHLREFCYKTSSHGIPMLGQAPNMIYRCFLIQKYEDVHRDILSCVFRIVWIILLSGCAFTFIYEAIAVVDKYYRMDKITDIQLKFDTAPFPAITLCNLNPYRDSGIRDEESVNKILNVFNMVMKMAANAGDLDELSKMKITAIGIGNSAKKRNVDDIGTIEPANSVCICEDGECEAEPDKVPTKDDTECICAFDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSK4</accession>
    <name>A0A0D8XSK4_DICVI</name>
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        <submittedName>
            <fullName evidence="1">50S ribosomal protein L18 domain protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">DICVIV_08597</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716412">
        <property type="protein sequence ID" value="KJH45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSK4"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="55" mass="6502" checksum="9A4B760F99D256BC" modified="2015-05-27" version="1">MREVDALARNVIENAIKLLRSFISDALYELDSTETYVTERLESLVKYSEEMWTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSS7</accession>
    <name>A0A0D8XSS7_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSS7"/>
    <dbReference type="STRING" id="29172.A0A0D8XSS7"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11727" checksum="5A1A6C570854D565" modified="2015-05-27" version="1">MIYMGVVQPQISYCDYLHFEVVEMRKVCPLMGPKMSAFWCGKCSLYLRDIENKYSEKAMQCWIAAGMYGVTLILLEDPIFIDRQGLIKYQKFQHERSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSW3</accession>
    <name>A0A0D8XSW3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716406">
        <property type="protein sequence ID" value="KJH45471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XSW3"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF15">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13115" checksum="1367C7C379AAC103" modified="2015-05-27" version="1">MTICAYKVPVCVGGDLHIHQCASRRFCPVVRYWSRKWTPWCVRFFLHFAISTDLGEIMVFFFPKGMRGPNGPPIYPGLYAVVGAAAYTGAVTHTLSVAMIICELTGQLAPILPVLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT14</accession>
    <name>A0A0D8XT14_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716329">
        <property type="protein sequence ID" value="KJH46894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT14"/>
    <dbReference type="STRING" id="29172.A0A0D8XT14"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000158">
        <property type="entry name" value="Zinc finger protein 362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001172">
        <property type="entry name" value="Zinc finger protein rotund"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="239"/>
            <end position="266"/>
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        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="40612" checksum="DBACA6C6BA1E8741" modified="2015-05-27" version="1">MSEFGDSSTFLQKCSFSTSRVYWYDEYKRKIQRFATLTKQSSLIITNNKVNNNKFESKPDVGQLQSQMQMREAKPYKCTQCVKSFANSSYLSQHMRIHLGIKPFGPCQYCGKKFDPDISLYFTFTEVILNERVFFHFLRNELKQYVTNFYLSDEYRNKRPIVAFRKEAFPLALLANQQQRDILTRKRKYFTQLSHLQQHIRTHTGEKPYKCKYTGCEKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEQSLLEHIPKHKESKHLKVHICPFCGKSYTQATYLQKHMTKHADRTRTNPLGSFPPDFPVDHLDLNSSWNGLPMPDNSHTQQFDISEFFEGVPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT22</accession>
    <name>A0A0D8XT22_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Globin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716329">
        <property type="protein sequence ID" value="KJH46904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5859312at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxygen binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Globins"/>
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        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
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        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
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        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20983" checksum="AB53C36514FA71AE" modified="2015-05-27" version="1">MVYCRSEFQLESSCPVVAQCFSSTQQVLSTAQSSVRTVTDHAKFLLTMLDKIMDNEQDIEEIREIGARHCILKQKYGLGTVELDKFQEIFVDVILKQDGVRNSKEASRAWRILICSIVDVFRDGFEAQLRQFRRKHSFNAHTQYFENIERRVSNASLRKSSLNADSQVNHCTRRMSQLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT36</accession>
    <name>A0A0D8XT36_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heparan-sulfate 6-O-sulfotransferase</fullName>
            <ecNumber evidence="8">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56604"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140604"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sulfotransferase 6 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="8"/>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT36"/>
    <dbReference type="STRING" id="29172.A0A0D8XT36"/>
    <dbReference type="OrthoDB" id="406981at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017095">
        <property type="term" value="F:heparan sulfate 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010635">
        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="30953" checksum="57C4D1E4E2A01661" modified="2015-05-27" version="1">MTILREPISRFISEYRHVNRGATWIASRHLCNGRPPTSDELPLCFDPNVGWDDVSLNEFLHCPFNLAFNRQTRMLADLTLVNCYSRNGTDSRTRDRILLESAKKNLKDMTFFGIKERMDDSQVMFQQLFNIRLYIDLKTTLFDSFNRRLSAWNRSKSNDTDVTDKQMKLIREHNELDIELYSYALKLFDHRLAAVLNRSSTMREPSLEFKSLINQHDGQLIYSHAVGGEGGLPSQKNMVLNDVEYEIDDDDANTSDENVDIEFVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT56</accession>
    <name>A0A0D8XT56_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716327">
        <property type="protein sequence ID" value="KJH46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT56"/>
    <dbReference type="STRING" id="29172.A0A0D8XT56"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="313" mass="35979" checksum="E539ED2DE0856476" modified="2015-05-27" version="1">MTGTERKVFQKYYPPDYDPTKLPRAKGAKSRQFVQRVMTPFNMQCNTCHEYIYKGKKFNMKRETVEGEDYLGLRLFRFYFKCPNCLAEITFKTDLENCDYQNEHGATRLFEAIKLYQDAEKAKEAKEEEEKKDPMKMLEKRTMMSRAEMEAMGNLEDLQEISRNKEAVDVESFLEATKPELSIAEQVKLQEEEDEALIRNIYGKTSEGKIIKRIDDEVYDDATPSSSRHLLMVDPLESKPVDNKSTVVIDVPKRPKDQKSLLSKIVVVKKQKVEVKMEPVEDSPMQIPSSSSKATNSLLGLCEYGSESGSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT74</accession>
    <name>A0A0D8XT74_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716324">
        <property type="protein sequence ID" value="KJH47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT74"/>
    <dbReference type="STRING" id="29172.A0A0D8XT74"/>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="45413" checksum="022CB61F11105E03" modified="2015-05-27" version="1">MMISGKNTTDFDKKSLRLISPRFMSIMPESSNSTTDEMNLLSPSLFSLHNKGKDIDYITSLSSLLTSAGMKSARDREDWMDLIIEASGVSDTLKNTKDNAWMNNMTHIRGPDGQPIYLDKNNITKIYGENEASKIEVFERLQKSFTQQQLREMNRTGYTFLTSQQRELVYGISSPFNNSETLAIISNVSDDTVHRTILSAIHEIADGRLQFRVRNGTITLAKRSSTTREKRSIVLSPIAKSLFLNNPQSVSQPIILSPVIFSALIYSPAIFGVVVLSPWLFLPIVLSPRILSPVVLSPFTFVPIILSPLAFLPIILSPGVMNPFILSPFLLSPFILSPQAMTPLILSPFALSPFIATPNVLSPLVLSPFVLSPLIFSPSYVSALVLSPYALSPAVNSTPSIFTAIASPSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTA1</accession>
    <name>A0A0D8XTA1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716291">
        <property type="protein sequence ID" value="KJH47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTA1"/>
    <dbReference type="STRING" id="29172.A0A0D8XTA1"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="247" mass="28295" checksum="7EF44E5295A50E61" modified="2015-05-27" version="1">MLRYRIEFVSEMTVPEACFHTKYHSSWYATDTIYMYNLLQPTWWNCQWERVNFWMAACVLKLVPCVLLTVFMTLLVRMLIEARERRSRLCGGAATGNSKAERTTAMLTGIVAVFLITELPQGILGLAAGVNPRLIFITNPLGNFFDLLSLINSAVNFLLCALMSHVFRREFLHTFGICCPHSSENHSGAPNMKSRNTKFFSTFVTRKSKSGFRAIPTNERNLRDVRYDEIDTTTTKNTRIQKLSTLK</sequence>
</entry>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="35"/>
            <end position="48"/>
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH47735.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="11539" checksum="67C39462D699DDF5" modified="2015-05-27" version="1">MKVDETTVSETKTCTISSMSVASAISDDERRYESADSTISTTPSPSRSGHVAQWQKGGTAKSAGLFISQENEKMNRCVIVMKSVVEMVDSRLVANQHRIIRVEVM</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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            <end position="313"/>
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            <begin position="818"/>
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            <dbReference type="Pfam" id="PF14680"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
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    </evidence>
    <sequence length="875" mass="99053" checksum="18D6595FDFD0ADEA" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="156"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="212" mass="23626" checksum="D4B1F82372A45405" modified="2015-05-27" version="1">MMTTSDRNIIVFQMKSVRTGRPPGYVFFTKKKRKSDRMILLKALDCEEQQMIGFNSVVQSAATSIHVLTGLNFQSLQSYGSHKSIAQTDHSIGTPTLHQRFTDDRKCFSSRLLMFIAGISMLGASSSEDDDDDFVNGEAPELSYAVSKRPIFGQLSPRSASPAPSDSVSQTNSLKRNNSSSTYRRKDSCHSQTPARSKITPYSDEVYLVYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
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    </dbReference>
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        <source>
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        <source>
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    <sequence length="187" mass="22268" checksum="2220E80D829FA417" modified="2015-05-27" version="1">MTENRLENNENFYVLLDGYYAFANISSNNFTDNFSRRSLVELGGMEKRLVIERNRFLTNKAKWLLKIAITSQAVRYVLVNAYIQYNYFLHNHFIKANEDYVDSWPRSYAIGIFGSQKIEIHFNQLRNPLLDFEVVSGCKVGYNYHIFILIVQIYQERVSLKMCVCISYMFIFFHFLFSAIFSNYFIK</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716296">
        <property type="protein sequence ID" value="KJH47702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV72"/>
    <dbReference type="STRING" id="29172.A0A0D8XV72"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="116" mass="12751" checksum="85B18CFD6C7F2B14" modified="2015-05-27" version="1">MAPIVKKPQVKKNAENINTRLSMVMKTGKYVLGYKQTLKALRNGKAKLVIIANNTPPLRKSEIEYYAMLAKTGVHHYNGNNIELGTACGKLYHVCTLSVTDAGDSDIIRSMPSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG7</accession>
    <name>A0A0D8XVG7_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVG7"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="58" mass="6505" checksum="1AAF50402A1D50CF" modified="2015-05-27" version="1">MPFEKGVGFDLAIKNEAYAFQIFVNGERFTSFAHRCDPNDITGLQIQGDIELTGIQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVI5</accession>
    <name>A0A0D8XVI5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AN1-like Zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716291">
        <property type="protein sequence ID" value="KJH47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVI5"/>
    <dbReference type="STRING" id="29172.A0A0D8XVI5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="28816" checksum="4459D1E3C2430FD7" modified="2015-05-27" version="1">MENQQQPSTTSLCRNGCGFFGSQANEGLCSKCFKDSIKRNQDTARLSSNGAGLSANVCRIDWVLTGCVVYWGAGASFSICLWDRNMGMWRIPMPMAASSSTLISDCPMTETPAQTCAQAAHAASDVTAKLESAEAIAASQPETTCVFMIDIEVPCFVVGFVNGFVASDSQIFFWHRLRFSCVIITDAGNVSVDATVPVKKANRCQMCKKRVGLTGFTCRCGGLYCGDHRYDQAHNCSFDYKTMEREEIRKNNPVVVSDKIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW17</accession>
    <name>A0A0D8XW17_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="KJH48823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XW17"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
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            <begin position="46"/>
            <end position="70"/>
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            <end position="203"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28593" checksum="833570AD8BC1E022" modified="2015-05-27" version="1">MIGVVIGSAMFGQFSDLYGRKKITVMLLIGTLFTSLLSSFSPSMDIYVAIRMITGVFCGGLITVGMILVVENLPTKHRLWMSTLVTWAPNYVLFAIVAYVMGEWRSLNLACNIVTAIAIILLIFTNTDRVNFFFVPFLFLSTLKNAIKFSVDEIESMVDKAITLARETERRKKKYTFIHLYSNVSIAIMTLVLSFGMFAVSYVTCGLIFNLHVIQGSIFWNTALSGGLRLDYWNDCTSFCIIYEGKTDYCNNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWE6</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="167"/>
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            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="40"/>
            <end position="51"/>
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        <location>
            <begin position="105"/>
            <end position="119"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH48104.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24599" checksum="7D5B5E41C4D676E9" modified="2015-05-27" version="1">MLVERGVCTRSPTDTIHTQCSNSLSTDRIYDRPTSDASRKTTSYSSYSTPKSHYDTSSDEYYTGKVSVRKMSSSNSNPYEKIPAMNSFHSTNSSRERVRPWDNHTSSSCSTCPTGSEGSWSEHSSTVSDSTLQNRRLISPKPEPPPRWKPYQTNSTFSQSNPNLGTSHAIKHYSSAVPLQTVSRNELSTPQRSLVNLFNPQTHAKAHNTAVSRKSVIETAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP4</accession>
    <name>A0A0D8XWP4_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05681</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716275">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="167" mass="18980" checksum="96A8BB74CC52D790" modified="2015-05-27" version="1">MLSNTVCCAVQLSIGDALQQVLHGDTEKNGWDRARSARLGASGVVIGPMMTVWYRYLDAKYVERRLPIVVKKVLIDACTNPVFSSTIITVCGLLEGKTFREAINEYLSKMFHILKVDLSIWPPVQFISFLLLPPPLRVFYINVVYLIYSCIISFIKHNDKEEIEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP6</accession>
    <name>A0A0D8XWP6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like Heme/Steroid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04910</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWP6"/>
    <dbReference type="STRING" id="29172.A0A0D8XWP6"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="102"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="39783" checksum="F848365EC48EFF2D" modified="2015-05-27" version="1">MVSKLLRLNPALYTTALVYLAVQVAFLSFLCSYYDYGLRNFTQWTLTQLYKFDYTREKIGWVKEVWKDVPKFDPGFSKKKIDHDKIETIDAEIHLGDTMQILNTEQLALFDGSRSSRPIYLAILGRVYNVDKGKKHYGVGGGYHFFAGRDATRAFVTGDFTEAGLIDDTSGLSHEDLLGIRDWVSFYEKDYKLVGVLVGRYYDINGNPTDELHNVLGRIQTAAEWRNSKAAEVEVFPPCNSEWHQSSGGRVWCTMKSGGIQRDWAGVPRLLYDPNTKQKRCACVKNFGVGLSSTGSVSNSRGDLDHPNLKVFGFPFFLLNDLNNIRTAHQHRIAAKLKMASEDVQLAYCGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWW5</accession>
    <name>A0A0D8XWW5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716274">
        <property type="protein sequence ID" value="KJH48249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWW5"/>
    <dbReference type="STRING" id="29172.A0A0D8XWW5"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="329" mass="37783" checksum="71BD2959193E55BE" modified="2015-05-27" version="1">MLRLIKQQSSPELDLSDPRQLALHKLYRLERITPSKRGVDLLKTPRLNKGMAFSLYERQYLGLHGLLPPAFMTEEQQAYRVMKKLRGQANDLERFIQLDSLQDRNEKLFYRVLCDNIKELMPIVYTPTVGLACQEFGFIYRSPKGLYITINDNSISKIYQILSNWPSRNVQAIVVTDGERILGLGDLGAYGIGIPVGKLSLYVALAGLHPEWCLPVLIDVGTDNQKMLNDPFYIGLRRNRVRGKEYDTLIDNFMKACTKRFGRDTLVQFEDFGNQNAYRLLDRYKNEYCMFNDDIQGTASVVVAGLLAATRITKKKLSKQKIVFLERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY99</accession>
    <name>A0A0D8XY99_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716258">
        <property type="protein sequence ID" value="KJH48719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY99"/>
    <dbReference type="OrthoDB" id="5813706at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="24969" checksum="2E4870ECAAC65374" modified="2015-05-27" version="1">MNEDIVVSKSTYDDFSSPTPWRSFEIIVDERSFFVNAGWLAELSPFFAHYCFAEEVHRSLIIDDIKPSDMLEFFRCIFFCPMRKPLSVMNVSLILRVASRFDMKPVVARCEQFVARSANTLDRDNLFQVTCAVSHCDPNSSTMSVLVDKLASIKEEDLSRMQFSQMPGDVVAEVYTQKFRERERKRQLWCCFVSWMERFNRRRRRRAMKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYG4</accession>
    <name>A0A0D8XYG4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RasGEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="246"/>
        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="74"/>
        </location>
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        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="29846" checksum="F8B66EE5A8626F10" modified="2015-05-27" version="1">MASVSGLLSEETAFLGSCLAVRAADQEYFGGKQVYTTVVPSTSKFLDEGHCHGHSQSHDHGHGQGRVHERDHGHRHEHKHRNVHAHGHKQGYGNSHENNHEREYDHKNSQGKELIPKPDMHVVPKCELNVAIQYAKEVIAKALSGENLPHGITFIGNFVIYDIQQEVKILRKENEEIRKELAELREALEKFVRKQVIPVKESHISDVNIAEGNSVDEDFDLFGSDDEDAEKAKVVQERLKEYNEKKSKKVFIKSNKSSVLRQV</sequence>
</entry>
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    <accession>A0A0D8XZP0</accession>
    <name>A0A0D8XZP0_DICVI</name>
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        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_06144</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
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        </reaction>
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        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
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    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005115316" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
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        <location>
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            <end position="601"/>
        </location>
    </feature>
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            <end position="178"/>
        </location>
    </feature>
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            <end position="524"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="610" mass="70096" checksum="61A8E0D09CBA9B27" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZV4</accession>
    <name>A0A0D8XZV4_DICVI</name>
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        <submittedName>
            <fullName evidence="14">Cation transporter family protein</fullName>
        </submittedName>
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        <name evidence="14" type="ORF">DICVIV_04427</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ligand-Gated ion Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NRIONCHANNEL"/>
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    </dbReference>
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    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="345"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
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            <begin position="77"/>
            <end position="281"/>
        </location>
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        <location>
            <begin position="290"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH49412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="480" mass="55516" checksum="B9480DA64E7A3EE6" modified="2015-05-27" version="1">MKSIVFAMVFFHLPREIEAVRGALVLKKSHQQSIDSDDNVEEIEELEDDEEIYYANEVDKASIYEQGETRDFLQFLKKIKYDHRQCPDGDNGGPVSVNVSIVVSNVRSVSEVTMDYSIEMFYREAWRDPRLKYSKAIFKNKTEISLHESYSNFLWHPDTFVPNAIASKNPRKQSITHRSLLRLRNDGSILYSRRLSLVVTCGMDLTLFPFDSQLCKLGIESYGYTADQVRYFWSHGKIEALILHKIRLPDFRIKESFVTSRVETYATGDYSRLYVCFVFSRSAGFCFLQLIIPSTAVVITSWVSLWMENETSFQDMISIILTITFLLFSYNEVMPRVSYIKAMDVYLGVCFCIVFCSLIKLAIVKYMRQRLRLTRDTSIVAGLLPMVRLSNGITDTNTSFTVEHSCLKKNPLSQTATGLYNTPSVNKLESTISIDSKLKTPHFTPQFMHRFHWISQCHSSSVLFYFVYSIFLFTQIFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZY3</accession>
    <name>A0A0D8XZY3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="KN716238">
        <property type="protein sequence ID" value="KJH49329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZY3"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
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        <property type="entry name" value="GDC_P"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="4">
        <location>
            <begin position="184"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="648" mass="72636" checksum="C6490B8148B7C65E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y034</accession>
    <name>A0A0D8Y034_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716236">
        <property type="protein sequence ID" value="KJH49384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y034"/>
    <dbReference type="STRING" id="29172.A0A0D8Y034"/>
    <dbReference type="OrthoDB" id="20799at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="315" mass="35886" checksum="D3317EF469600EB0" modified="2015-05-27" version="1">MCFFLGPLEIIAERESIYRLLGQVTKDNMNKMISKYTIDPRTRYVSLDVSLQPEDVVQIISSDNPRLAPIGQPLSMNNTYCVHENPILRIYSLWKFCYHALLPYILVFDMDSCWQDGRSLAGLVAKFFPEILDYYQVVIFNAVESIGITPPCRPSEWATLKVVDKITYIEKLVKLIKCSKSRLELALSPCIRSSQKKDFRELVCSRPKKSEPIQKLADNLLSCSTFTNECDMLSVHDYDKEIAESDVVLKKKEFLDASEIGECCHHDAVPSLMSVAAVQPERRISTSVMSALYDSVNVKRQEICRLCGKVVEFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0U3</accession>
    <name>A0A0D8Y0U3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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                <person name="Choi Y.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="4">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="3">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="43907" checksum="54AABFEB27670899" modified="2015-05-27" version="1">MVPEFVGDLMESMIASPEASPSTSRDECWYTEKTGRLFGYNEIVAPWSTKRYSLSIEGLHEEIKDIFQWLRPCRLEEAIRLEVFRKVRSAIKERWKNNNVRVSVFGSLRTRLFLPTSDIDVLVECDEWKDSDIMSHCMQETANYLEEKNLAKSVAVFSDAYVPIVKMVEKDTLVNVDISFNTAQGVKAADYIEKRDTVPKYSVQVKEEFPVVEPLILVLKQFLILRRLNTTYTGGLSSYGLILMLINFLHTQNKYVNESNQFMIACVIIGTLIETPAASGDRLPTALSCFVEECTLLRTFCNFMHYGMPVRRKHPYSAEVNLGELLMRFFEVYAQEVNYERVGISVMDMRYTLKEQHDVDKKQAMLSIEDPLLINDIIGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5G7</accession>
    <name>A0A0D8Y5G7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5G7"/>
    <dbReference type="OrthoDB" id="7754674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="11500" checksum="04F08DE82A21DAED" modified="2015-05-27" version="1">MPQSNESIPTTVTAAGFGKNPNIPSKTRPMQVVNLTYQETTGDRIVTNTTGSTICLGDSGGPLFKTNGTHYVLLGISSTNRKENCSNTPKKSEQLVLFLCKNFIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5R4</accession>
    <name>A0A0D8Y5R4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SZT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716186">
        <property type="protein sequence ID" value="KJH51324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5R4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5R4"/>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="108700" checksum="BCB217C2C18785D2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5X0</accession>
    <name>A0A0D8Y5X0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_02230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5X0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5X0"/>
    <dbReference type="OrthoDB" id="5807605at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone"/>
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    </dbReference>
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        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13648" checksum="E6CCEBFBECF8A25C" modified="2015-05-27" version="1">MPPKPSAKGAKKAAKSQKVSRSGDKKKKHRRKESYSVYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIAAEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6M9</accession>
    <name>A0A0D8Y6M9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6M9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6M9"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase EF-hand" evidence="8">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="500" mass="57229" checksum="4F22AA7EC4F8403F" modified="2015-05-27" version="1">MRQNTVVGQTVRRTLSHESSHGSQLQELIFDLYRDEKTNKIFIPRFFKEWTDAGIRKDDPRLQDIINQVREAEANVDEGVFNQEHLFLDKEAFKRCVGNSIGVIGKALKKQLVIPDWTSFTTVMGNLYEQSRIEDSGLSVSKPFTYALVHEEIGPDDLHSHVGQEPSGRLFNDICLDHNSLFFLFYNNNNKYRQQKPHNPLINAGAIVVASLMKRHASLSDRFDFVFPPDTNLQDTLDLYFQLCAIETNCDSMAVMAATLANGGVNPMNSERVINNRACRDTLSLMYSCGMYDWSGQFAFRVGLPAKSGVSGDMIMVIPNVMGIAIYSPRLDTLGNTFRGLKFAEAFISKFNFHNYDSLVYSDCQKMDPRKVIPETEHDNTSRFMFAAKYGDISTIKRYLLLGIDIHERDYDDRTVLHVAASEGDSSCLKYLLSKWRESPASTYRIFTSVIDILLGVYLFVFVEPRDRFGRTPLDDAKFFKHEECERVLQEFIDQWTCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6P7</accession>
    <name>A0A0D8Y6P7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6P7"/>
    <dbReference type="OrthoDB" id="5811295at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="15038" checksum="5D13F29C039618FD" modified="2015-05-27" version="1">MNHFHDMPLPPNYDDRLWITKILDHMSYEEAFDQRHKIPFRPVKKDRTANIHNKWVYKVEWELYNSDRIQTWEIEDQLVHLKELDVYKEKNGIIDEESRIYTRCRWTSSEDEADVSPEQTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6T7</accession>
    <name>A0A0D8Y6T7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6T7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6T7"/>
    <dbReference type="OrthoDB" id="10267155at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="338" mass="36652" checksum="6B0732DD7EE9CB33" modified="2015-05-27" version="1">MALPQHVQFRTTAIRLPTAPQHVQFRTTAIRLPTPVNSEARDKIRTSKSSEEDSAYAGFGSTSPTSSTQSSMSLQSSSSKGSHEVVCQAVSVVEENPNASETVVNKPASDGQLERFCHIVDAYDSIDPNLSICYENISSDFVKSVEQKRGDIYDKPTLAVKGISSSLPQAAENEELELEPETPKSELPNTRKSLPSPTVGIVSPMLNQRKVESQESAVAEPTFPYFDCGPSSSAKSTETKPLAIPCKSISQSAVAEPTFPYFDCGPSSSAKSTETKPLAIPCKSISRVETTFDCTPPAMAQIRQLPAYQQLVEQGRIQRNRLGSGSIYGLHIEHSHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y789</accession>
    <name>A0A0D8Y789_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Guanylate cyclase</fullName>
            <ecNumber evidence="3 13">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_01774</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y789"/>
    <dbReference type="STRING" id="29172.A0A0D8Y789"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="162"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="511"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH52072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117020" checksum="A10F3FAE6F2B3FB8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7M0</accession>
    <name>A0A0D8Y7M0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA synthetases class I (E and Q) anti-codon binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="11027" checksum="F7743F261C4DE3E7" modified="2015-05-27" version="1">MAAAKCVEWLQQFKSKNPEDLDEVPNGFLSDVNKESLTVLYNVLIDRYLSSSKVYDHYQFERVGFFTVDQDTELGKIIPQYFDVNTFTIATTDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y813</accession>
    <name>A0A0D8Y813_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH50706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8279" checksum="95E3D51DD1EEC182" modified="2015-05-27" version="1">MKISCYLVKSSLLVKCGKQLSPMITLIYLMFTIALTTYVICSKPKPKIMTPSMRSVAVLPQNQPNDTKSDNKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8Q9</accession>
    <name>A0A0D8Y8Q9_DICVI</name>
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    </protein>
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        <name evidence="1" type="ORF">DICVIV_00514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5859197at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="318" mass="35440" checksum="04D7BBD4E2170842" modified="2015-05-27" version="1">MGLSLKSEHDSQLLCLLDVFCATIQCAKSVKQWQTLSVNEHDLEIRISMIASYLLSCRLPEILNPVLSLSISTDLFAKLNLLHLEFSGISSDDTSNLAAAFCALQLKVSMSAIRSYFSATELTNTELINGGVAERFTDSAIRMCLSLSNHPHSWSLLMEIHERSMRVLLVIGHIIRCGERELCDSSLVLATLVLAGKYAAFDKYHQASICEASLPCLPFTQSCVIGGQRSLLFAVASLPVYYLTRASLRVPFLIALITMTYECELATQLLSEELNVKHLLKFITEVREGNLSNLEPIQRLIPHCTVDSLIQYYKIVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8X9</accession>
    <name>A0A0D8Y8X9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UAA transporter family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_02802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y8X9"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
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            <end position="96"/>
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    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="202"/>
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            <end position="243"/>
        </location>
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            <end position="275"/>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35557" checksum="22EA5699B23BA3B9" modified="2015-05-27" version="1">MLVQMTPAIRSAIFYVVSTMFCSLLGKIVVTRFFFDYPIVILMLQMATTLFIVELLRVLGVLKLSPYSFDKGRHFLLPSLLLCIAQWLTVVAFEGIGMPAFESVKRITPLIILIGTNAISRQSRIDNAQLIGVIGISFASLLTVNLELSLDHYSLFYGLTAAVLQAIAYMQFEVLSRTYQAVELLYIHSFNSLIFFLIADVVQDEIRDAFMYMLTSAHPLFGGVFAVLLLSGILIQFATFVCIEQNGALKTQILSNIRASFQIFIAYYLSLYLFYDVTPSFLNYISLICTVGAAYYLYNQRSSECMPIKNPLSNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y935</accession>
    <name>A0A0D8Y935_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
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        <name evidence="8" type="ORF">DICVIV_01163</name>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Elbow/Noc family.</text>
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    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN ELBOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="239"/>
            <end position="273"/>
        </location>
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        <location>
            <begin position="29"/>
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    </feature>
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            <begin position="73"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="304" mass="32952" checksum="DCD37BF98F68F708" modified="2015-05-27" version="1">MFCDYVEAGKSPLAMLAKTCETIGLPDTPSKKSLLEKKDDTNKKDIESPTERRKERSPRTSPSTATSIRGESAASTTTYTGLPKPSQTTFPPVGFSPTLQFPFPYTMMPYALPFPSFPMAFSMTRPPCPSMVLQRPCVTPGCTSCSPDMLNSFATHPLFSAYCSMPSVSSAPMSYQNFLISPTTVPSTSSVTTTSPPTGILSKMSNSQQKHVCSWVESTGICGKQFGSADDLALHVKQLHTPSPPSNVSSTTADASKSQQTRTNLPRFHPYSKPNHIPISPMMSFPSALQAMYAQRLMSGMPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9A0</accession>
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            <fullName evidence="2">Protein FAM50 homolog</fullName>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9A0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9A0"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="38336" checksum="6614202B44818CEF" modified="2015-05-27" version="1">MSRADAGRLIHLSKKRERAKEDMEQQLKRMEEESSRMHLSNTGSAGISSKFTANYDAVEEHLKSKTVGLVTLDEMREKQKDVVIDREETVVRGEDSKIQRSSTKNSNVMGQEKCAQKRVLSFDFEDEEEEVIPVLTKKIGVFMILVGMDPTIDTSFLPDKDREAEIAKRKTELAAEWRAQQEREKNEEITVAFAYWDGSSHRKNLKVKKGNTISQFLTWAIEVLKKEFTELKTTVSENLMFVKEDLIIPHFYTFQDFIVTKAMGKTGPLYEFDAAGDVRIRQDAALDCGEAHPAKVVLRSWYEKNKHIYPASRWEPFIPNKKYGRTIDDLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9E2</accession>
    <name>A0A0D8Y9E2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Replication factor RFC1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9E2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9E2"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    </dbReference>
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        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication factor RFC1 C-terminal" evidence="9">
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            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="53566" checksum="C66879543C8F54C9" modified="2015-05-27" version="1">MVEMNASDVRSKKSLEQRITQLTESHQIEEYFTAVHRNNDENEVKHVLIMDEVDGMSGTEDRAGISELIQIIKETKIPIICICNDRQHPKIRSLANYCFDIRFQKPRVEQIRARLMSIACQEKVKVSKEEMDQMIELSGHDVRQSIYNLQLFSSAGGQAKVQKKDMAVGPFEAARKLLDSRSTLQEKQDMFFVDYGIMPLFVQENYPNMRNDKHTAKQAIAGLRKAADLISHGDIIERCIRSTGTWKLLNEQAIIGCALPSIAVDGHLRAMIQFPSWLGKNSTANKRQRIMRQLATHAHLKMSADIPYVVVDYVPVLHDCLTKPLLEREADGVFEVVCIMNDYCLVREDNEAISELAVWPGKVDPSSKILPKVKAALTRALNKEHRSLPYPTGDVAKGRKKTLFDYEVEMDEDGNLIEKMDEESGFEDDSDDEDYKPGAKSKTKARSSTSTASRGRGRGSCATGPQRGSFKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9E3</accession>
    <name>A0A0D8Y9E3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9E3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
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        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="559" mass="63791" checksum="22C71AB158032536" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9K3</accession>
    <name>A0A0D8Y9K3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase Rpb3/Rpb11 dimerization domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9K3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9K3"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="462" mass="52332" checksum="0FD7D54326B9539E" modified="2015-05-27" version="1">MGAKRSSKIKNETNNPVTSKNEIKLEEERVLNIVFVNEADNGMSLDFDLINVEAPIANTLRRILLAEVPSMAIEKVYLYQNTSVIQVIGVNEHGVDCEEEPKPDSSRTVVFNINVTCTRNRDAPSTATEPHNLYHQSSVYSKSFKWVPCGDQLCSDDKVAVVADARRDTCSRNVFRHSDLSSVVELGRKKNHFIFNVESTGALKSAELVIEACKISKPIADAVIRYGKDHPLFRNKILIPIGKEVESGLVRMTTSLRMKRLGLGESSKTAAVSEAAALEQASDLVQQLVLFTYSLVVFFGYYYYTKKNTPENLKLTDFEEFCEKNEKRSDSDKSKNDSKRETATEKKSRSTRVSSLPIDAASCIVLEGEYITQEINNHIVQTIFLCKLIIFIFYLFTLVLLWFLYCIVVIGKSMVFSRKKLQAPFLSHCALLSLSRLLLPRWYIIYTNVQVMLRIAQYGHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA29</accession>
    <name>A0A0D8YA29_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin-tyrosine ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA29"/>
    <dbReference type="STRING" id="29172.A0A0D8YA29"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019098">
        <property type="term" value="P:reproductive behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="141"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="483" mass="55744" checksum="2F3CBCFDB9B63A02" modified="2015-05-27" version="1">MCGLTDLVSSCLSKANNNRNRVNSTQQTQPFLRASLFTGIPPTIRFYTKGTKVSKPSKKITCRLTWCHNSLLPIVMRNSLSASHFTIVDESLFFIGYWGRHLKSSQYRSFKPHQKVNHYPGAFHIGRKDRLWMHIEKQQRRFGEHVYGIMPKTYLLPKDYERMRSYLDASPTHHVIVKPPASARGTGISVTRKIKDIPEKTQLVAQQYSRCLSTVSNKYMHLTNYSINKLAEQDGVANSPVAKWRLSELWQFFESNDINSDNVRERIEDVIMKAFIACEKPIRDHMTRHIQHGFICHELFGVDILLDEDLRPWLLEVNISPSLHSGTSLDVSVKAPLAKDVLNMAGITVPPSAEEMSAADYSTKPRNWPKDDDHMQKEAVWTAAFRKEGVLNPKILKRLTDEDIRTLVEFEDEYVRRGNFRLIFPTSETANMQSLFVQPVYANLMLQQWQIEQEQQGREVGIERIESLCSQRFARNRNNNSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBD0</accession>
    <name>A0A0D8YBD0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBD0"/>
    <dbReference type="STRING" id="29172.A0A0D8YBD0"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF742">
        <property type="entry name" value="PROTEIN DHS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15295" checksum="52DC1AEF931744BD" modified="2015-05-27" version="1">MIEQVVDTAVMIVKCFAMTITASVKALLPMGLFPGEVVLITGSGSGLGRGMAMEFGKLGAKIVLWDINENGNLETKKMLEDINAESKYARNHGFPFQKKIALLYIYSVDQNQNRVALVESPDKEIIRKHMGCIFILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBT5</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="26293" checksum="F344761330E10387" modified="2015-05-27" version="1">MINLLVVCKCCKVGDVNFLSLVFQLDRNGNCTGISEYTPGLTDIVNTVWYGTVFRFYIRNIMTVFLPFFLLSYLNYRIVRTLRKKHRAAELFQMSSDHKKKIRSATRLLVLIVCSYLIANVLNVLITLWEYIAFQSTQTQEVYEVYEFCTDVISVLYVLVCATRLFIYIICNKVTMFIAMFIVVNNVKKSELRDNGHRLRKVGTEVDAVAVAIARHLLRPNNSDDADC</sequence>
</entry>
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    <accession>A0A0D8YD22</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11520" checksum="D68F4F19A2EBE21E" modified="2015-05-27" version="1">MRDCTLPHITSDRNEIYVSDIRDRRLGSLETIDRALYKAWNALQSCCSNIDVSSMFVGYKMYNSSARCMKAIATATATATATATATATATATATHYFCFLQYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YE45</accession>
    <name>A0A0D8YE45_DICVI</name>
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            <fullName evidence="2">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
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    </dbReference>
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        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52891.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="301" mass="33071" checksum="FBD5CF7FF41A7543" modified="2015-05-27" version="1">MGPIFGEGDSLITLLSLVGMPPQRTYLFLGCYFGLGFAPLESLVLLFCLKCLYPTKVYLLKGHLEEPASIKNLGLDDWLLRRKIPPESVTRVSEIVMRTVAQMPIGAMIGQKILCLPGGPGPIIREQGLAALKNCTRSSMNQLDRSICMEAAWAVMKLESNPVTVNDGIPTFTESQCSAFCKANGLVLLVDEGFLNYPKEVLTIVSAVAYLDNFRNYAAAITFQGTLNALSTASCFTPRTPKESFEDINRCVIEAVEFPDFLCDRLRSRASVVRYKMDEGEPKSLDIVKPGIGRNSMALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YE55</accession>
    <name>A0A0D8YE55_DICVI</name>
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        <submittedName>
            <fullName evidence="3">K+ channel tetramerization domain protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">DICVIV_00947</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20406" checksum="4A2F9AA34D91AF26" modified="2015-05-27" version="1">MSKVNVNTLKEIKDLKESENRQNRSKDMENQQDRNAVCPPFLKQPAATPPSPRLTAINPLILVFDGAANTQCQKVLHISNVSNERVAWRVLCNAPTRYVVTPNKGFLFRQEKITVQVLLLNSSKYHRRHAFVVQVKPAKIEESNRKLTWKDLSPNEMKVIQSTRVSTLSPNDEMRTAKG</sequence>
</entry>
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    <accession>A0A0D8X5Z7</accession>
    <name>A0A0D8X5Z7_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719248">
        <property type="protein sequence ID" value="KJH39918.1"/>
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        <property type="entry name" value="DUF236"/>
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    <dbReference type="Pfam" id="PF03057">
        <property type="entry name" value="DUF236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="64" mass="6860" checksum="3B97FC40EA8E14DC" modified="2015-05-27" version="1" fragment="single">SEEKGIEIFGANETGIFLAGTRPDTYCNNGDAGGALNIRAPQENRKVATFDPNYQTLAGLNNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7B7</accession>
    <name>A0A0D8X7B7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetraspanin family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_13606</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717213">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20239" checksum="C4F8B8F90F3F5A60" modified="2015-05-27" version="1">MGTFGFWSAYGALGRTIRSLYFFSSTCIIVYSIVCMAYGAWLVSTRGQYSELLAPSLYVDVARILVVVSALALINQIVCIFSIYKELRFWIYASSIAALIIFIMLFIGGIMGLVFRSQLITQIPLRLKMLTSLKELYGTTDMQKITDAWDQLQSNVRSISLIISILLSFKKKIDQLIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8C5</accession>
    <name>A0A0D8X8C5_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719419">
        <property type="protein sequence ID" value="KJH39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8C5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7091" checksum="7C07244B0EE0008D" modified="2015-05-27" version="1">MPKTGTTGVDPVSFTDTNAVTGAGTEKATGSAMMDLITGLQKNKGSSSSGDSMSSILQCLFKGYGFVLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8U9</accession>
    <name>A0A0D8X8U9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI inositol-deacylase</fullName>
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    <gene>
        <name evidence="1" type="ORF">DICVIV_13024</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716933">
        <property type="protein sequence ID" value="KJH41010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8U9"/>
    <dbReference type="STRING" id="29172.A0A0D8X8U9"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58325" checksum="E28E4453BABD6F76" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X904</accession>
    <name>A0A0D8X904_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IFT121 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717525">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X904"/>
    <dbReference type="STRING" id="29172.A0A0D8X904"/>
    <dbReference type="OrthoDB" id="10260567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="1">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12363" checksum="C4950A16E64C9FA0" modified="2015-05-27" version="1">MHCSSLSGCSWDPTGVKLALSSENLLWLCNVRARYKWGYCGHTVVYSYEKSERGDCRVVFYESKLDEVHSKPVRYLEQIAASGDYCVIASRPDDVLGKVVYYHNKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9C7</accession>
    <name>A0A0D8X9C7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12847</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716885">
        <property type="protein sequence ID" value="KJH41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X9C7"/>
    <dbReference type="OrthoDB" id="5866288at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="10888" checksum="9249EED0638264A9" modified="2015-05-27" version="1">MNRHDGAHGPVHMGSNGLRIPTFYMDGLDGFGKQELYGTITVEGQNGIYEPSYTNETLIWWSRSGIRPLDEPLCGFTGRQIYIEALVGSGFHAWSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9D2</accession>
    <name>A0A0D8X9D2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717278">
        <property type="protein sequence ID" value="KJH40377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9D2"/>
    <dbReference type="OrthoDB" id="5873253at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="387" mass="45170" checksum="513E3A11E5141C17" modified="2015-05-27" version="1">MLPLAINGKITMKENFLIAERIKSILSKEVVIMIGNEKVPSCVLPSLPHEVNDEYTYHYLTTYYSFKLEESNVMAPSTFKYVYGVVITKHKEKPIKQVVTVYYFRWKSLFITDNKVLRDKRRMPSEYDEILQLAMVYKPGETICISNRRKEVFSLLHMFYTFCYIMKEPIGFIDALQLHTEKCNGSMLDRDELLFVMAVIMEWAFQSDSLTDGLDESHREWCHSYAIMAAFMRKNPNIRISAVKRHMEVDILIDLGKSSTSDCFNLYRKLIHPDYLTKLDEDVKKSLLHDYFQSSPQFSERNSVASIDRFHRKNVYHSSIEKKECKNNKKSTIESKNKLSLSIKKEKQKKAEVISKNKVVEAEKKSKKFDDTEATQLSSLKYTVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9D3</accession>
    <name>A0A0D8X9D3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716884">
        <property type="protein sequence ID" value="KJH41185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9D3"/>
    <dbReference type="STRING" id="29172.A0A0D8X9D3"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19372" checksum="5A9B2BF89DB54CF1" modified="2015-05-27" version="1">MNRTVRQFISPIELFRFSVVDAPAEKKIQMQKIGVIYFLYLLLYAGLEFTLPFLTHLRFNFNSIQQGKIYLFTGLLMLPIQSCVVRRTPMIRQKCVVKIGIMCIIPAFMVVAQATNQFTLYLGLFLYAIVFWLSGPTWCYMIGGTLLTIPLILLIRLENPVHDLKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9I0</accession>
    <name>A0A0D8X9I0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongation factor Tu protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717218">
        <property type="protein sequence ID" value="KJH40432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9I0"/>
    <dbReference type="STRING" id="29172.A0A0D8X9I0"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTu-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="204" mass="22982" checksum="13FF8F8F4FDD0825" modified="2015-05-27" version="1">MAGTIKVNDTLLLGPNSVGEFVPLPVKSIHRKRMPVSSVRCGQTASFALRKVTKRDVRKGMVMLDSRMNPVSCMMFEAEILILHHPTTIKPNYQAMLHIGSIRQTATLVSMTKEVLRTGDRDRVMFRFIRLPEYIRTGTRMVFREGRTKAVGTVVNVIPQSTLSQQRGKLKDKTNRACLFLVRRGGAKPITNSKMTGKKQDNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA37</accession>
    <name>A0A0D8XA37_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_12570</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="13"/>
    <dbReference type="EMBL" id="KN716821">
        <property type="protein sequence ID" value="KJH41455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA37"/>
    <dbReference type="STRING" id="29172.A0A0D8XA37"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000060">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF253">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE MCA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1230"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1231"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH41455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139441" checksum="4B54154DF65AC69C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA61</accession>
    <name>A0A0D8XA61_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elapor1-like galactose binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717065">
        <property type="protein sequence ID" value="KJH40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA61"/>
    <dbReference type="STRING" id="29172.A0A0D8XA61"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056609">
        <property type="entry name" value="Elapor1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF15">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23032">
        <property type="entry name" value="GBD_ELAPOR1-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elapor1-like galactose binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20711" checksum="D32D99630AC47C14" modified="2015-05-27" version="1">MLFLAYSCVAGNYLDIVTQSCRPCLPGQYSLGGGARFEEFYTLPPGFSVENFDANSLQNEGAVSSHAMSCPPETGWIVRDSELLYIPSPCVSRLSFSAQLVRPGYVDFSYRMPKNNRALSLQVEVRNQQCQSYRDVVQSLLTKYVSSEKSHRGEASGNWQKRTVYLRTGEAKKCFLKSFYYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAD0</accession>
    <name>A0A0D8XAD0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="7"/>
    <dbReference type="EMBL" id="KN716807">
        <property type="protein sequence ID" value="KJH41528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAD0"/>
    <dbReference type="STRING" id="29172.A0A0D8XAD0"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="306" mass="35601" checksum="A1962D53E16F7B6F" modified="2015-05-27" version="1">MLREICHRIDWVLVGGRWTRISVMGTNLSSESFHENKYDVENCVVVLMIPGNPGNEGFYRDFGQKVLRSLLSREERMGNRERHYLFYTSSERFQLDEQVQHKLDFVLEHLPKAAKIYILGHSIGAYMMLRILPYIKDEFNVKKAIGLFPTVEKLADSPNGLRLRRVLAMLDSNQWLAKLLSFWLDYIPNSMKRWLVLWNVDGDVAPDNVIVAATELLNMNVFRNIVHLSNDEFNKVNDLDDTLVVNKELLYFYYGKQDGWCPEELGYLMEQRLPDGHVLVDEQGCEHAFVIRDGATIAEKLLQFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB70</accession>
    <name>A0A0D8XB70_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
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            <end position="103"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    <sequence length="103" mass="11653" checksum="F83B445EE5DBE2AA" modified="2015-05-27" version="1">MCSQVVALTLVYHNPIQMFDTSSASWQHTPQPPPPLSASSKRKSDRSESPNSALKRRFRTNFTEAQSLLLEEAFQESHYPDQAAKKHMAEKLDIPEDRITVGL</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="90517" checksum="F9A5FF19619114BA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCT5</accession>
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        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
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    <organism evidence="2 3">
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        <name type="common">Bovine lungworm</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716667">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="318" mass="36100" checksum="20CF102180742CA0" modified="2015-05-27" version="1">MDLSLLPEEVLVNVLRLTSPTTVIAAKRLNKKLNRIVEQNHLGKPHVDDFSVEMRTFVSRTRPLGRLQLKNPCGKLHRRVVVTMKRKNKSKYIVQEGIEGPSNSGLNLIGEEMKKVNLDERLSFDGVTADIEFYNMLTAKWNDLRCVNSLSFTLCRLKLSEEQMLSLLTRTNCHSLTFDFCHFEHDIISDKVLSAIVSLQSLRVQPRSDVFLHQLTNATLRSWASSPPTTIALYSCVTNITLQGIYDMIMSLSDDSVVDWDFGRVLPSEGVHGQLFSMMSMSGMTILICDDFRSRRVQLARGDSRIAFNLVKEEAFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD40</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13718</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEX0"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="C:RISC-loading complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:deoxyribonuclease I activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
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        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="169" mass="19216" checksum="92771464531C71FF" modified="2015-05-27" version="1">MYMVTTEEEIDEGQEEDIEVPKAMSDIFESVAGAVYLDANRDLDIVWRVFFNLMRKTIEECCAYPPRSPIRELMELEPGKTRFSKMERIIETGKVRVTVDIGNKMKFTGMGRNYRIAKTTAAKRALNSSCDVITALSYIADKEIVLPGIDCSNRDQIPQKHGRAEVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFB9</accession>
    <name>A0A0D8XFB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine dehydrogenase/PNT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716894">
        <property type="protein sequence ID" value="KJH41141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFB9"/>
    <dbReference type="STRING" id="29172.A0A0D8XFB9"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="3">
        <location>
            <begin position="199"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="472" mass="52972" checksum="66E168651CFE2CA9" modified="2015-05-27" version="1">MLIHRLTSYTVTIIRKSNTFVGKGKPTLGIRRETINAWERRAPLAPKHVKKLTRCGVGVLIQPSNRRAYPIQDYISAGAIVREDLSDAHLIISVKQVPIDQLIPNKTYAFFSHTIKAQQDNMEMLDTILQRRIRLIDYEKIVDERGKRLVMFGKWAGNAGFIDILHGLGLRLLALGHNTPFLHVGLAHNYSDSHMAINALRDIGYEIALGRMPRSLGPLVFVFTGSGNVSQGAQELFQHLPHEFVDVSTLPKVAQKGELNKVYGCVVTRADHLVAKNGSVHEFEKHPDRYISKFATEIAPYATVIINGVYWDARTPRLITIPDAKQLFTPVHKLDTPGCPSLPHRLVAICDISADPGGSIEFMTECTTIDRPFMIYDADFHTTSFFCFSFDCPSGCLVCSIDNMPAQMPLEATSQFGDLLYPYIIDMLNCTTDQSFEHLSCRPEVHRAIITDNGKLTKNYEYIADLRNAKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFE5</accession>
    <name>A0A0D8XFE5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716668">
        <property type="protein sequence ID" value="KJH42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFE5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFE5"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="415" mass="48128" checksum="703DB0B7BB6E1B6E" modified="2015-05-27" version="1">MNEGSSSKAVRSFPLAPFIPALLRILLWCRAEKLRLFTAATVISISSLKDISFILDWISKCDLKNVRANHIHAVLSLMSFVLKINNYGEVKERVRKILMDLIRTGLWLKWCDLNKYVFLLMCNDLHLEFTTSIDTNDLVLTKRPLAEAVLLGGNFDYVNLGSDYELRLEIYRYIQKSAENVKNVKFILDYVIDDLKNCVTERDASRILDVIYLNKESFSDTDRKAIAEYVLLRLGNWKMPNTISLARRLLAFLFNKVTASTEELKWIEQCTYVEEKLSKEIALQVGAHYLKQGFDKRVLTHMIVFLQDDDLHIRELASTILSPFLLKTDRVLNPAVCYRLMRETVLPSEDEMTKKEVRHTEMPFNWVIRRSSKETLYDACSSNPYAETGYFGDYNEVKVMINDLLQSDNREQANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG34</accession>
    <name>A0A0D8XG34_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ndr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716850">
        <property type="protein sequence ID" value="KJH41326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG34"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
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        <source>
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    <sequence length="340" mass="38432" checksum="16BFC7FABCBDFD34" modified="2015-05-27" version="1">MTSMEMHAFTNDQQPLIDNQIPQMNEEKVDTIYGKVKVSIYGNPSKHPLITFHDLGLDSESNFQNFFQFVSIAEFTEKFCIYNINAPGQEVDAQTLPDNYVYPTMDNLARMVETIVDHFGLQSVIAFGVGVGANVLLRYALLNQRRLDALILVNCAATTAGWIEWAYHKMNIRYLRSMGMNTFTIDYLMWHHFGRRLDECSPDIVRQYRIYFQHLSNPTNLAMFIESYLNRTAILISRDGQSGPALSVPVLQIVGAGSPFVNDTVDVNSKLDPSRSDWIKVSDACGLVLDDRPEIVTESMILFLQGLGFFPTMNVVKLMKKIQDTQNGSCLAVTDNVNEC</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KJH44140.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Domain of unknown function DB" evidence="1">
        <location>
            <begin position="98"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="25099" checksum="129CE9D0D1EE7356" modified="2015-05-27" version="1">MIRCETQKAVVPRHCVGSIPILTVFQCKSNGACGCCGCRAKAKARAANTNHVNGDVVNDDDRDDGNIFGLQLWNKTNLPINSDNIARYTNPNFLFHSCCEERRLPAACIQKCHFNTYEKEVLESMFVGTDECSIDFLPEMQFCAAQGMDHTKCCIDNGVDRTAAGDKCLTFCDQRPDHYTPIDYSYAPCYDRFEDMKRCFYNQIRVSAEKHFIPMIKEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK49</accession>
    <name>A0A0D8XK49_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_08982</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
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        <property type="protein sequence ID" value="KJH44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK49"/>
    <dbReference type="STRING" id="29172.A0A0D8XK49"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:dendrite"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ephrin receptor 1"/>
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        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="279"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="687" mass="77106" checksum="9CDBB0C61D50E9CA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK59</accession>
    <name>A0A0D8XK59_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">Chloride transporter, ClC family</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cl-channel_core"/>
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        <property type="entry name" value="Cl_channel_volt-gated"/>
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    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
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    <dbReference type="PANTHER" id="PTHR45720:SF13">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage_CLC"/>
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        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34667" checksum="662B3C086D65C2DD" modified="2015-05-27" version="1" fragment="single">MPTPNGGHHHTYSLKRIAIIRPLAACNHWEAAEITILTIRNHRQTQMRKLFDFSCFRLHKMEALRPIPNHIRPERHTKPLLSTYFYSLLIPGDKFGNVKMILSDWIFLAVLGVLVAFLSISVDMMIYYFQEDYEWKEGKQDGMHGSPSILYPLHQLQAMTLPISNRFDKLPISTSILSFLSWCAYTVGMVVASATFVHYISPQAIGSGIPEMKTIIRGVFGVAMSLGSGAPIGKMGPFVHIASVVANQLSCLASIFDPAFASEARRAECLAAACAVGVACTFSAPVGGQVNLRNSKVMNLAQEKLLRLATSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK76</accession>
    <name>A0A0D8XK76_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716434">
        <property type="protein sequence ID" value="KJH45008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK76"/>
    <dbReference type="STRING" id="29172.A0A0D8XK76"/>
    <dbReference type="OrthoDB" id="5870079at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="15910" checksum="38E10F7DF9C365E7" modified="2015-05-27" version="1">MVSAEQRRKLVNGYISHSNERAAIVDKEISDDDQLILVAPITCQNGNGLLKFNYWILGDQSAASLKVCTQDGEVKSCTQPIIYTESPNVTVDVVHPNAAVFEIDIVASNITQSTILILDNIDYKSDRCDDVEKPNGIEKNTEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKE4</accession>
    <name>A0A0D8XKE4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKE4"/>
    <dbReference type="OrthoDB" id="5818152at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19460" checksum="3D1539663702F816" modified="2015-05-27" version="1">MATIKIETTSHNLTEFKAHLETEGRDTFKKTANINVHNASYDAIKALPHQINITPSSGMKITTTLLLIFVAANAVPDCYYQFLKATIDCKSGSDCESGACVYSLNQNKRVCCEPKEDKIQPVCPSGKPAPLPVLCNPESNEVDICPDDYECRKSTSIFEKELFDAIRMFFQNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL18</accession>
    <name>A0A0D8XL18_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ets-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL18"/>
    <dbReference type="STRING" id="29172.A0A0D8XL18"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF182">
        <property type="entry name" value="SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="5">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="346"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="418" mass="47093" checksum="E00837BEA768BFBF" modified="2015-05-27" version="1">MNEIGSCAWPSMSPDAQVKTEYPLDDEMFQVGKVQEIVTFNITTDVKTEANEDIYNGFGANSFDSTNSSLTCENGSNQCQNGNACVDAQQMDIYRDLILRHLIQDISTTCAKLGLPTDAQNWTQEHGSRWISEMCQQFSLTSPRQTYISGRVLLSMSQKDFVALAPEGGDTLYAQLQLWKTAFESYHQQQNGSQNSGGITAADNSTPKNHWAMNTGGQTMVVDQPMKDTSTLRTEFVQQQYNTSDIHQQQRHYFSNGGIGNEAHDSHGFFGNGILPSPSGSDRSSNASMHDLGDEDCIDLQSMLQMQQDGMRFCGPMTNMNITSVSQTPSADEPRPSPFPRHSGTVHLWHFIRELLDHPNKQYGSCVRWVDRDEGTFKIESSHHLARFWGQRKNRAQMNYDKLSRSLRQYYKKGGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL51</accession>
    <name>A0A0D8XL51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716595">
        <property type="protein sequence ID" value="KJH43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL51"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8318" checksum="D7466F5117D95B32" modified="2015-05-27" version="1">MYNRTGLAPAPNVPNPRNAGRKKSNPTYESVIDVHVNNIPELADRHEKEIFPDVAHRSFFVDLCGNRALSSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLD2</accession>
    <name>A0A0D8XLD2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09407</name>
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    <organism evidence="2 3">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34351" checksum="9AA095E3F4C7A15D" modified="2015-05-27" version="1">MDSSFWVLTIFSASNYYEVGSNRGAYVKFIGRSKQPHFVQYMASKTHRKTTIRERKKERGKGCRGKKLLLFIPYFRSLDVISPILALFLVLTIFSASNYYEVGSNRGAYVKFIGRSKQPHFVQYMASKTHRKTTIRERSHKAILKDNRIKISYSDCNAVSLISRIVKIFTKQLLFYYRLNVVEESAVRELREKLGSFNNQLQNEFEKCDPRREGMISVHQWCECVERVTGLHLPWRVLAPKLSTLHSDGKHVLYNNIFAVVQVGNANQQVVIMLLLTKYKQLLSNKPYKISFVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPD7</accession>
    <name>A0A0D8XPD7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_07563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPD7"/>
    <dbReference type="STRING" id="29172.A0A0D8XPD7"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="350" mass="40431" checksum="2D5288C246914F78" modified="2015-05-27" version="1">MDQSIIRVPVDVKSNNRSFPRFEQPERLGEYTVTRDRCLVPGRENAKYLYEAALTDGVQVDFDLNKGFSTFEEKSGEEKLDILLDWIISQASRGGPLKKVLHEADFVCWRGLLTRIASTPYCPETSWQFSAAKIKGVIFLCERETEDMRQRKETMTQRDKLMSYWGFKFEQYMTVAEKNSKPNVNEPVTSLEEFGVVVRSVLGTSIGRALRLVYSGEVDAINNDGRLVELKTQRHALEGSFWKQKSMKWWLQSFLIGIDHIIVGYRNDDGIVKKVESLQIDELTKRGEWSGNVCINLLSTVLNSVRELLVEGGACQVRYEHHRDEITIHSIPLRNIDFFTYDFRVHFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPH0</accession>
    <name>A0A0D8XPH0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPH0"/>
    <dbReference type="STRING" id="29172.A0A0D8XPH0"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19250" checksum="C1D4D4C33DC7B681" modified="2015-05-27" version="1">MRRAIGGPEQIQIWMEQQIVALQAVNMYNNGFFQVPNPQLLAPPTDHLPRSPLLRQSTLDIDVSLGAGPLKGTTLWRRSRSESDVSRSLTIGPFTCTTCGQAFALHDRLAKHIASRHRDRSASAIAEADGAKSHKCNVCNKSFGRSDMLTRYVLKKNCIHSSLGIKTIIINIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPU3</accession>
    <name>A0A0D8XPU3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716386">
        <property type="protein sequence ID" value="KJH45804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPU3"/>
    <dbReference type="STRING" id="29172.A0A0D8XPU3"/>
    <dbReference type="OrthoDB" id="5989213at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16238:SF7">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="237" mass="27547" checksum="060CAAFA382EE522" modified="2015-05-27" version="1">MKAISMRKIIIELSKINHWEGVTEFKCEMEVFENLSWSRDARFSSFWAHFKAVKKWRSDHAQMVSLSCRLPQEKYAEIPALETPNILSKIGLCLASTSHHVALPNRDCGAAYVKDDLQVAKDAPGHSAAERECNLMERDDKRVHWIELPLDEYISADKSSLFYLLTFFLIGVYGVQKRTFSLPDEEEQTRSRRMNARNLYGSSAERILAMETLIDMRFEQEYAKKRPPLWPNIPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQW9</accession>
    <name>A0A0D8XQW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </reference>
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    <sequence length="124" mass="14557" checksum="46D21C4ABBD32D34" modified="2015-05-27" version="1">MNMILLVLLHQCHFHHWTNCFLIDTLLAINLMLRFLKALIQWFVYIHSKQNSNLTEISADLTMTTLEITGSGEIVVKNRCTGGTNDIDHHRTFIENKKTKFLYCWIAKLYQYSLDALQSWLNLI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
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            <dbReference type="SMART" id="SM01071"/>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="306" mass="35884" checksum="F4408E0CD773044F" modified="2015-05-27" version="1">MPIDYSKWKAIEVSDDEDDTHPNIDTPSLFRWRHQARLERMAEKKQKKEEIEKNKTTSNSKIEEIEKKLAGTDISEEERICLEKELAEIKEQEAKWLAKEKELEERLLNVLRLPFCLEQERLEPWNVDTIGHEAFSFSRINKVGEKKPLPKLSDEEDTKRMTNFFDQNESLIQEYGKLTTLGESEEFILEHPHLASEYTANYLTIDALNLAIDHKEAEMSNIARQCIIIQYLLELAKNMNAVPTNVNIIKAFFKKFRSADPQYLKLYTDEVAAFEERLIRRAKEKRDAALAEYEAEEKVMLTLLML</sequence>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716433">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336138" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="66" mass="7404" checksum="1C64D35CCDA10AAD" modified="2015-05-27" version="1">MKSLMIIWCLLVLLCVTELTSAKGKVIDIFNGGGGDIIGLRRTNNSNHNYGNVGDRMRHVDEHENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS08</accession>
    <name>A0A0D8XS08_DICVI</name>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="13">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="25027" checksum="2695C430B0A33EAF" modified="2015-05-27" version="1">MELRHYEDGLRMISGWRQNQDILFGANERKVMLSYGRNPQKWESDSDYNKREAIERNEFEALRPMPRHHVSFTSKELFEEHKKVLRGEYWDSSPEDLTKEAFVLANMYAAARQAQIEVPQPNIPQKWKEQNQQDIKDENDRLDKLRGFIRENKYEKLTEQLAKMMEKNSIDEPHSSVNVESEVDGNDGFDVRSMMKTIQAAVHRYKNFDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTC6</accession>
    <name>A0A0D8XTC6_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_06906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTC6"/>
    <dbReference type="OrthoDB" id="5857231at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336084" evidence="1">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="24072" checksum="DCEA345408854A2A" modified="2015-05-27" version="1">MLFGVLGLLITAPFLHACSPLPPGEERKIAFKVDGITLPMEFTYSDQQNVTQNYPKVQVTSNDAIMNLQKYVKKAVSKAIKEVAKERGFEGYVSQIQQQIKTIVYYNPMLCYEMEPEPVIGTTPPTYTSGIGYFCLEKDDTVTKILYDSKTEPVGDIPKEFQSFIVILSIRNFIVSIWDRNTWEITVTKFEKQLRRGDYGPYFRGADVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTJ0</accession>
    <name>A0A0D8XTJ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XTJ0"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1260:FF:000003">
        <property type="entry name" value="Intermediate filament protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000058">
        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000023">
        <property type="entry name" value="Intermediate filament protein ifa-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
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        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
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        <property type="entry name" value="Intermed_filament_ifa/ifb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
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    </dbReference>
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        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM01391">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="10">
        <location>
            <begin position="73"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
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            <end position="75"/>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="547" mass="63302" checksum="26B201B69B50603C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTT6</accession>
    <name>A0A0D8XTT6_DICVI</name>
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            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716282">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="285" mass="33521" checksum="2A80682243E47514" modified="2015-05-27" version="1">MVKVDELLLVLLPGIKLNIRSDIVCSSYVILQAEYASTYNKDFIKPFSFAEGPYQTIYLLRANLAISLLKKGKSFWMMQQDTFWRKNLFELGFEDDLSYDAIFDQLGANDKSMRASWINGANFFVRANNDTIKFFERLSDKLAHWYTPDMGVMIHQCHTWTRPRCAYFPYELAHSWEWMYTSQKNPPYILQLDCETDGGSKLMQLGKYGFHFVDNNGTCDHEKVRQARNRMESGSVEVRRNFPSWGRLQFKAYWYIVEYILWIPYIGQLLKPYLALVGYILMITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV56</accession>
    <name>A0A0D8XV56_DICVI</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04870">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="588" mass="67880" checksum="C3C5AE427AAD08B6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW30</accession>
    <name>A0A0D8XW30_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716345">
        <property type="protein sequence ID" value="KJH46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW30"/>
    <dbReference type="STRING" id="29172.A0A0D8XW30"/>
    <dbReference type="OrthoDB" id="5864586at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="53" mass="5781" checksum="898FBA88528E1D2B" modified="2015-05-27" version="1">MTLTKMTSDNFHEATDDNQTLSVIGVGGLILMVAITLIIKAYRIKNADKAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW94</accession>
    <name>A0A0D8XW94_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000001">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
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        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF48">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="6">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="38717" checksum="FF0B09ABA11EB040" modified="2015-05-27" version="1" fragment="single">MQTSALYIFKEDSPSSTTVLTSLTNVTYVDISSRAEDIQAGLIDTFLNLEKVDKNLFLARHLLKGRNSLPVVYGGQVIGQALTAATATVGSGFLPNSLHSYFLQSGNVNMPILFMVDRIRDGRSFCTRLVKAVQNGDAIFTVQISFHKCLLSELQPEPDSIAHQLTMPDVIGPDGLLDWNQLMEEAAKNPELHSAASAMIRFKRKEIPPAFFRIFSFRPVDVNSFLFQTSLIDGKKLPDQESFRSYMWIKANENIGDDPRLHVAAAAYISDATMIETALRPHSRMGFIPSMALTLDHSIWMHSDQFRIDDWLLYENHSTIASMCSLLFFYEMTNPIFGQCLTNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWH4</accession>
    <name>A0A0D8XWH4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor E2F/dimerization partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWH4"/>
    <dbReference type="STRING" id="29172.A0A0D8XWH4"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
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            <begin position="83"/>
            <end position="109"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="517" mass="59829" checksum="18D2597515EB1657" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWQ2</accession>
    <name>A0A0D8XWQ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RED-like protein region</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">DICVIV_04915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RED family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012492">
        <property type="entry name" value="RED_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07807">
        <property type="entry name" value="RED_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein RED C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="393"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH48945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="508" mass="59700" checksum="4E5468C791E7DA46" modified="2015-05-27" version="1">MTETANLRNEDFRKLLNAPKKVVAEASASGDASHSFTHRHQAKPDKKKGGGGHKHKKEKIEHNEDEATLKEILKNYRDRALERRLKGNDDSDEIVKLAAAYRAMPGDARAISDKANLRRQAIEESKYLGGDMEHTHLVKGLDYSLLNKVRSEINKSQAEVENVDELELAFDQKGVDAVEKMSENKMVRAMHRILFKNELPLRNELFGKGRMAYVVDMEDEDCDIPTTLLRSVHDCPKAESNANINANNMLISKLTQVLSYLRSDHKKKKKPDMTEEEIKKYQSQSIYDNEADYAPKKDKERDRRDKDREQKKDRNYFDSKDDRTKRDDRDKRDKDRDRRSGRDHDRRDRDRERDRERDREKDREREKERKEKEEKDKEKRLEEKMEKRRREAEGGGYDECYPGGMAEMGGGWDSDEEDLTMMDMGAKKSSIKRWEFENDDEYEKFQGAREAMPKAAYQYGVKTGDGRKTRKSVDVNKKIDKELNQINKLIEKRKSGMEEERDYKRPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX80</accession>
    <name>A0A0D8XX80_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase family M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF05649"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48374.1"/>
        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH47291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="373" mass="40641" checksum="1F154CCF1BF4F459" modified="2015-05-27" version="1">MSDVNILPLRNRYPSKYSCLPRVTRNCPEDHKCVPSSREGMHICCRAKPNRVSALSAENQSSSNQSQSSTTETLLRMSEWVAVMNSIKVCAPFRKSAVSICCHSFTTLCGPGSTVEMDGLLARDCSNVPCSVGFECSLTPFGDRVCCSLAECSNGQRARAVCAGGCRNDEICEVIQQQRWCCPIVKTITRKCPDNRVSNGAICSPSSPICDDGYECEESFDQEGYLCCQNGQLSTTTLSSWVKTFTNDQTMAATSSTNDPIISVRLHKCHNGANPLMIDGEYLKCPELGAPCPKAGYTCQFGDGGLYCCPLNVIDILEASTVSIFTPPTESSENCRECVPEQPPAPKCPFAFREARSQTSDEFKTCIGLLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYU9</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12374" checksum="CD2F3796F0478494" modified="2015-05-27" version="1">MAILNIRATRPYYAAAWAIFNGCLMTLTVDESESQKSDPPTRKQPANPLPRKFSSLQVSHYPVLLLSNTKSSDQTSSVIWKMRYVDVLTCFEDAMVLFVSFFEKGKNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ27</accession>
    <name>A0A0D8XZ27_DICVI</name>
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        <submittedName>
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    <organism evidence="2 3">
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26765" checksum="DBF09C198D42BB82" modified="2015-05-27" version="1">MDNSVLFSYIILYTTATVHGLNCYTGRYYTIPQDVMAIDTMPNVWACAVRVRVDIHSRRLIAFELYGIDNRLNLSSTINDKHILSCTIGYPIVMGLLNAEYICNHRDKCNYVLGFLRCMSYKEKKFSTQLAAQLILDAITDDLLAPHRPDDEEKLSQLFFFHKELSTYLSSHLNDKSIIMFLRDIYYAHVFNTIVAVLIIAVTFTYIHLAGCTIFLNVIILRKKTHVIRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ71</accession>
    <name>A0A0D8XZ71_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04771</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ71"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ71"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into peroxisome membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pex19, mPTS binding domain"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="247" mass="27262" checksum="DC98E631ADF7A234" modified="2015-05-27" version="1">MSDKDSGLSKDGSHDVDGLNNLLDDALKGFTERPRTTDDELDEIMAEQDQAAAQKAAGDFQAMLQQMVKVQEEALRQAESSGQHVAEYEEETKNMIDAMKALMECSGKTLASKAVMYPPLKEIHDNYPGFFAEHGVSLDSETRQRYEKQYEIIGKICREFEKEPDVQPELVQKTECSIEQKKRSIGVIDSSVSNFETLGKLLVELQSYGYPPKEITGDLPAGWAVDDTTGLPKVSDVSAAAGSCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XZH4_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="16745" checksum="1B4EDB09FD6B8759" modified="2015-05-27" version="1">MDCTASSIEPLTSSSLELPLSSGICQEQNNQIRKKLRVIHSVKCRQNGVLAQVQLPQASAELLAQMPAKSVIQDDIRSGNGRFQLVRKRGRSEVWNLFGQVLDSLTNVRLPYVACYACKVLYTDTGGGTGNMTRHRCPIGLSYRSSAHGWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZS4</accession>
    <name>A0A0D8XZS4_DICVI</name>
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        <submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716241">
        <property type="protein sequence ID" value="KJH49249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZS4"/>
    <dbReference type="STRING" id="29172.A0A0D8XZS4"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="311" mass="35721" checksum="FF0B057453264023" modified="2015-05-27" version="1">MKSLKLSAVVKLLKLMHGRRRATIFLIEHLIEILEAICPRIGKKSLPWIKDEKSCLSLHGDITTISSAVEELLPILWRTFSMTVSYFRDQLNSSAVITTETDVTYWFFIPKICIYCMYEMFQIVEQLTNLFRLCLITLEHLFSWTHVSSMPSDSDALATRKKCRREKMMEIIEHCILHENEKNAGSEAEITVSEFLVDICEVAPSVGVAIAILDCFSVMRSSSSELSNKMDKLPNPAILPHFLSARHTLAFLKKEWVDQEGKSIKGATLNLAVPHDEKRKSKVYEQNSYDPDLNERDTNQIFACFTRYIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y076</accession>
    <name>A0A0D8Y076_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03622</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716211">
        <property type="protein sequence ID" value="KJH50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y076"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NIPA1 (NonImprinted gene in Prader-Willi/Angelman syndrome region 1) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
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        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39234" checksum="B2607EE56BFD1694" modified="2015-05-27" version="1">MGRNETSMAATTTPSKMSDFYIGLVLAVSSSLFIGSSFIIKKKALIKLASGDVSQRASEGGYGYLREWMWWMGVITMGIGEACNFAAYAFAPASLVTPLGALSVLVTAVLSSHLLKERLNLLGKIGCAVCLLGSTVIVIHSPKEEEVASMADLALKMKDAVFILYVITVILVTLFVIIYVAPRYGRSNIIVYISVCSLIGSLSVLSVKGLGLAIKETISGNQQLTNILTYFWLISVTACVSVQLVYLNKALDMFNTSMVTPIYYVFFTSFVILASSILYKEWSCLGASDILGNVIGFLTTIIGIFQMQLFRDVNISLRQVRVLLHRPSASLASLDLSSNSVTNLVDDFNTQSNGANRHAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0C0</accession>
    <name>A0A0D8Y0C0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716214">
        <property type="protein sequence ID" value="KJH50155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0C0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0C0"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF1">
        <property type="entry name" value="HYDROXY-ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0520">NAD</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14233" checksum="0BD839175003C965" modified="2015-05-27" version="1">MNDRRRFAGLHFFNPVPVMKLVEVVSTPETSHETHSKLIGFCKSLEKQPASCKDTPGFIVNGLLVPYLLDSIRMLERKDATKEDIDADFSIQCIQKLSGQFDLPHKSWVALPNQTDTRELLASTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0F6</accession>
    <name>A0A0D8Y0F6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beige/BEACH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y0F6"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2084"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2581"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="12">
        <location>
            <begin position="2171"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="11">
        <location>
            <begin position="2328"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2757"/>
            <end position="2788"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="3028"/>
            <end position="3088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2120"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2925"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2133"/>
            <end position="2155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH49519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="3091" mass="346255" checksum="5A491AC3A84DE7F0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0P6</accession>
    <name>A0A0D8Y0P6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0P6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0P6"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051774">
        <property type="entry name" value="Sperm-specific_class_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22947:SF7">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="11917" checksum="3FDE86FD3E6D5DE5" modified="2015-05-27" version="1">MPQEFDFPALISLPASGGTTTHQLSNPSDQKMIFKVRSTNNNDYRVNPAYGFVAASANTNIEITRLPGAPVPNDKLVVQFAPAPPDAFNPQEAFSKVEPIGNVTINLVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0T4</accession>
    <name>A0A0D8Y0T4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0T4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0T4"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24450" checksum="6ED40676D707F4A6" modified="2015-05-27" version="1">MGDHYGFSLTTFSPSGKLMQIEYALNAVKNGQPSVGLRAKDGVVLSTENIASVLFEDQPKIEKISQHIGCVYSGMGPDFRILVKRARKIAMEYEMMYGEEIPTTQLVTQIAAVMQEYTQSGGVRPFGVSLLIAAIHRSRKGAYFAWKATALGKNDVNAKTFLEKRYSEALELDDGIHTALLTLRESFDVGMTEDNVEVAICNTKGFHRLTKQQVKDHLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y118</accession>
    <name>A0A0D8Y118_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716272">
        <property type="protein sequence ID" value="KJH48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y118"/>
    <dbReference type="STRING" id="29172.A0A0D8Y118"/>
    <dbReference type="OrthoDB" id="5775605at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF3">
        <property type="entry name" value="PAN DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336246" evidence="1">
        <location>
            <begin position="17"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="337"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="481" mass="53106" checksum="BD8F029B47F24E30" modified="2015-05-27" version="1">MLQAALLLSLCSTAVAVFECSNQETTAFVRIARARLDGTPVVVSTAGHDLTCAQYCRNNIEPTTGAQRVCASFNFDGRETCYFFDDAASPAGTSQLTANPSANNFYYEKTCLPGVSAHEACTYRSFSFERMRKTILEGFVRKSVQVANREQCLSACLKEKDFVCRSVNYNYDSYLCELSTEDRRSKPTHLRMAEGAVDYYDNNCLSRQNRCGPSGGNLVFVKSTNFEIKFYDHTQSVEAQESYCLQKCLDSLNTFCSAALVSPRGDNPMEQYQGYKVNALSWPSSGYRGSVEFNPSEKNCIVSDEDTFSRADQQGQIVGKDYYEPVCVAADLSSSTCRQQSAFERFIGSSIEGEVIASAQGVTIADCISLCFQNLNCKSINYDRSASTCFIYAVGRSDANVKANPAMDYYEFNCESQFGGMALCTNEGIRFIVNTKEPYTGAIYAAERFSTCSQVVENAKQISITFPPPTVSSDCGTVIRL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
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    <sequence length="393" mass="44070" checksum="05D3C5E29CCAB69E" modified="2015-05-27" version="1">MVKTPYVQSFKSTHVQKMKRWFKKYFMEGQYLEVDATDKLQALPENPTWEDLIFIKYRKFVAMLIPFVFMQIIWWMLAIRHNFFQWYPDYWHMPVTMILGSLIGGMTSEGSGAVAFPVMTLALHIAPSIARDFSLMIQSCGMTSALVCVVFMKVKIENRAIILGSLGAIPGFIIGVHFIDPLFTGGQKKMMFVSIWTAFAIALGILNSHGKRTTFKDIPDFCFWKGFILFVTGFVGGVFDAFAGSGVDICIFCVITLLFRVTEKTATPTTVVLKGVNAVFGFFYRAAMMGDISDVAWKYFSLSVPVASLAGPVGSFLGSHLHRQVIAGFVYILEVIALIGFLLTRPTWQLIAIGGCIIFGGFVFFSFISKAGQFLLKKIEKTELEKHQQTNKV</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
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        </source>
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            <dbReference type="Pfam" id="PF19718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH50224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="386" mass="44634" checksum="D59B2C4FE8363BC7" modified="2015-05-27" version="1">MITEDEVQGHEAHSRTRYWTELSGYTPVPSMAPCNEIKYGVFELATPLENFLRLDVDSRLLFGVFKKWLGLKLNIEPTQFVIVKHYKEDDKGYECNCSDSESVRSALENVFKINIKLRPPLREDEKLIRIVQFDLEETNRENWKALFDCVASKETTIKDLMLQCIQLYAEIYGQRLQLQQIRLRDMPSLNNPVKAVLNPADTLNCRGPQWSNNIYFQIITERLEPYFFLFKDERLIGRPGVPVLVRRFRPSTVEVSSIQEVLVDPYAANQMESFACSVSLLSSIPVERLAFTEVGSSWDKWPYALSKLAMLDGSVKFFTQPSYAPNEVIDRIGGRVVYYKDIAEVSKELSTEDRKQIQIKEHGHMSTSSRRKERPLRIQMSSISEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3F5</accession>
    <name>A0A0D8Y3F5_DICVI</name>
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        </recommendedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3F5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="168"/>
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    </feature>
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            <end position="275"/>
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            <end position="114"/>
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        </location>
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            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="425" mass="51056" checksum="4414709EC3FF3211" modified="2015-05-27" version="1">MRGHMLFWRLQKIAELESSSCDFRHDYSPIFLSSPRLLQYSEEIRDSENENIDEIISRLKNELFKNNTLEEINYMLREENDAALEANDNLRQDVVQLSRTLEQLERGVRNDRERFNIENARYRNHMEQQHRRLTELWKSFMALKRKVRDLHASTASDLDKQLTEFTRCAAIVKKAIRHTEFKNAEWRDKAVKEKDIMLEEVMVKYELLSTTQIETEKQLLEKTRQLQRLQEEFQQTRKNYYDLESALARICSMIQHSSPSSQQRARSESPSFPRMANDAIRKIRSVLTMRAAEIKEVNMRFEHAELEVNRLKKQIDLYENEKRSQKDYERRRDQEANERELQLVAMENDLRRTVERLSTLEQDRNMKESLITTMQNTLTSTHRNHKEFIEGLVSNHRDELIAREKLHEREVTERLNEVCPLFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y411_DICVI</name>
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            <fullName evidence="14">Solute carrier family 25 member 46</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716179">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y411"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="439"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH51623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68802" checksum="67714B9EDAA28203" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4I9</accession>
    <name>A0A0D8Y4I9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KH domain protein</fullName>
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        <name evidence="7" type="ORF">DICVIV_04418</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716234">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22451">
        <property type="entry name" value="KH-I_ScSCP160_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
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    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="263"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="332"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="428"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="510" mass="55866" checksum="3F6EEE64F2925C55" modified="2015-05-27" version="1">MYRYAYRVIDSLSSVTFGLDNDSLATSIPAVDVVQMDYTTDFPKLPEAASTFTKSLGAWTRPVVGAKTVVNSFVLAAEERANKVKSFGGNASEEHKKCQAVAAATGTRIELSESKDGSLTVVIKGLRNKVEDARARLIRDLQTQASRDLDIPKDHHRKLIGKEGVALRQLEADTNCRITIPSRDTPSETIKIVGPRDGIEKAVAYIRSVSERESKLATEHVVCPRIFYPFVRGPFNETYDKLTQETGAKINIPPSQVNNEQATVKSVTCTVARAQHRYIVGQQRSGLHTILKETGVSVEVPNEDENSDTITLRGDPSKLGEALALVYQRASSVITQQLDAPSWLHKHLIGPKGTTLQVPKLNWLQSNPYISANLSNLIGNSVKQLVPNRNKVQIDFEDSGSIFLEGPPDEVKAALSVLSSEVSRLLDEMAIEKVKVHPSLHRHVIGRGGALISKIKDETGVQISIPNEQTNSDEIVVEGKKDGVKKAVEEIRAIVSKIVSAYIVEIHGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4X8</accession>
    <name>A0A0D8Y4X8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-serine(in) = L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:35031"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4X8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4X8"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF20">
        <property type="entry name" value="SIDEROFLEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336197" evidence="10">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="60" mass="6731" checksum="3DEA85A78A35AEAD" modified="2015-05-27" version="1">MATPIQILMAGFFLTFSTPLCCAIFPQKSSIPIKKLEPELKKRIETCENPPGIVYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y594</accession>
    <name>A0A0D8Y594_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716185">
        <property type="protein sequence ID" value="KJH51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y594"/>
    <dbReference type="STRING" id="29172.A0A0D8Y594"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="39682" checksum="F3B427182A513300" modified="2015-05-27" version="1">MEKLETTIPHVIPRDLPPWRECLRDSFNDIRIEMNDTLLLPFSSGTSGKPRCVILTHRNYSSATEILKRALFNELVSNSRRRTVAVLPFYHASGFWALLYSLLDGCHTVIMESFHPISMLEIIQKYEIDTLNVVPSILTFLCRIDIDRFDVSSLSTVLCGSSPLGKELVSLFLKKFPNVQNLIQGYGMTEIVVLSHITPFGIMEEKHYGSCGKLLPGFEAVLMDENGLIVSGPNRPGELYLKSPTVMRGYLNSEDDDQQQPFDSDGWFRTGEDVILSLPYVKEVGVVGVDDAEHGQIPKAFVVLQHDVDEQIAMTTKLSPIKYLRGGIEIVNELPKTKSGKVKRNELRKIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6M8</accession>
    <name>A0A0D8Y6M8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DB module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
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        <location>
            <begin position="463"/>
            <end position="561"/>
        </location>
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        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="567" mass="63349" checksum="931C67B30C194A84" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y740</accession>
    <name>A0A0D8Y740_DICVI</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Metastrongylidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y740"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="664" mass="74386" checksum="7CA33353CE6E9C55" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8Y7B9</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716162">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="36251" checksum="4A4451A6881348DB" modified="2015-05-27" version="1">MLDVVRERFRCSFQSLTKRNIDQQEAIWEIVSTEYRYIQVRSQKHARFVVLFYRIAKTWIFQVCEVLINLVLINLRVKFFRDINASRVFLNYTELFTVNVIFWRRAIQPLLEWSRQSHKPFDPVLLLNGFEDISEWSKCYIPFNLGHDDSHTYIQKKQKDNELFKEFVQWAESQESMRRQKLCDTLTTPMQRLTRYTLLLKVCRNENELFSTHQYCVTRNHSFFRPYSQIRLTIVNVLLCKLTTRLFSAMIDRTDAATQQLNFELNNNDLRLQMAEIMKSIDGYDAVDSDEFEKVMAFLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7D4</accession>
    <name>A0A0D8Y7D4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7D4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7D4"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000013">
        <property type="entry name" value="Pre-mRNA-splicing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52738.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="696" mass="81336" checksum="695D3BD44E56E8F3" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7K5</accession>
    <name>A0A0D8Y7K5_DICVI</name>
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        <recommendedName>
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        <name evidence="3" type="ORF">DICVIV_01860</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14151" checksum="0E95E31676EAD496" modified="2015-05-27" version="1">MLLSLTFTLVHSLYYNGPVVKSPLDEDLAYNNEISMSIKQHQPQSVHTRDRRARLCGKKIIEQLLILCDSCILPVGSEIAKRSIYEENLTEAVHRLMKRELSIATKCCAGQCKLSELEKLCCKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">DICVIV_00748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y878"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="256"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="177"/>
        </location>
    </feature>
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        <location>
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            <end position="29"/>
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        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="482" mass="56081" checksum="8F3DCC62185EF515" modified="2015-05-27" version="1">MQQQRNMGTPCQPMGRYPNQPSTTPQSTMRRPGGPQLPSQATTMQANRVSQPLRKKKRYADKLISPQVRELVPESQAYMDLLAFEQKLDATITRKKLDIQEALKRPQKVKKRLRIYISHTFIAGKEPEKLWMFQEGEEGSVPMWELRVEGRLIEDQTNGSTTVGHSNPAPPARPLPKKKFSSFFKSLVIELDKDIYGPDNHLVEWHRTPTTNETDGFQVKRPGDRPVKCTILLLLDYQPMKFKLHPRLAKVVLPCFFDLFLMCSQSHFQVLGIAAETRPKIIEALWQYIKTHKLQDPVDHDTVNNDTFLEQVFSCKRMRFMEIPQRLHQLLQQPDPLVLSHIIKHNEGGAEKNTACYDIDVEVEDPLKQHMAAFVHTQANVQDIANLDQKIYDVVDQINEWKTRRDFYVRFADHPHEFIRKWLVSQSQDLKTMTEASGEGEAERRADHYYRPETQEGVFRYIYQKVQQKRAELEQGLGVRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8V4</accession>
    <name>A0A0D8Y8V4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8V4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8V4"/>
    <dbReference type="OrthoDB" id="5920520at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="288" mass="28096" checksum="448710F48A5ADE1F" modified="2015-05-27" version="1">MDLETRVKAYRFVAYSAVIFSFVAVLSVSITLPMVYNYVHHGAAKDIWSEVHVLKVTEQQGNRTARQASYSEGAVLSNKARAGGCESCCVKGPAGPAGVPGKHGAPGRPGAAGQPGNPGRPPTQPCEEVSPPPCKPCPQGPRGASGPPGQQGDAGVPGNAGKPGSEGATGVPGAKGPPGLPGKDGAPGAPGKPGTPAVSEPVASGSPGPAGESGPPGPSGPKGQPGKPGGPGRPGPKGSAGKPGAVGSVGNPGTHGNQGTQGSHGEKGICPKYCAIDGGVFFEDGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y930</accession>
    <name>A0A0D8Y930_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_00536</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y930"/>
    <dbReference type="STRING" id="29172.A0A0D8Y930"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="17">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH53225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="53187" checksum="3DF53F0380B576F3" modified="2015-05-27" version="1">MSFSRGTNTLNISVKLFVENRARLVAALKESYFFWTFGVHESDFFGVIDIGSGRTCLFPPKLDPSYAIWDGKINDENWFKKKYEVEEVHFNKDDAICAYLKKINAKNVLLLKASNSDSGNVLEAPSFIGKELFDIDVDKLYPVMAELRVFKTDKELEASFSGYVMRYVSKVASEAHRAAMKANLTINFLTYLPQCSSVFRHISYYHGGCRHLAYTCIAASGYNSSILHYGHANAPNDKQIKDGDICLLDMGPEYNCYASDITTSFPANGKFSDKQKLIYNAVLDANQSVFKAAKPGVRWTDMHILAEKVILTHLKEAGLVTGDVNEMVDARLGAVFMPHGLGHFIGLDVHDCGGYLGDALPRSMLPGLKSLRTTRTLQERMVITIEPGCYFIDTLLNAALENPNQSKYLVKSEVEKYRGQGGVRIEDDVIIWSNGNENMSDLPRTVEEIEDFMKNGEFTDETVQKSISHHLHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y954</accession>
    <name>A0A0D8Y954_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y954"/>
    <dbReference type="STRING" id="29172.A0A0D8Y954"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000087">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="175"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="369" mass="41492" checksum="A255B46197835F4D" modified="2015-05-27" version="1">MASTITTITPPNVSYIQMDSLVIMKIVKHVDSELYAGMSEVAGEACQGLLTGLVSVEKDDSRLEITNCFPTARAEPILESDENAVQASQMYEELKQQEMLDMLRKFRNMNIDYELVGFYQAHPFGACFSQDLVDSMFDYQSNGPDGVVIIYGILDPVKTRQGQLCLRAYRLSVPALELCAKNDWSPDAVKAANLTYQTMFEELPIVIKSSHLVNVMMAELSLAPTKISDRFSTHLELGSRRSLEKSVRSMMANIDELNKSISAYGKYVNDRQRHDNIIYNLTQKRQAENEQRIARGEPPLSMDDIRKLKEPQLQTRNGMLDAMLSSCETQALADFCIKVTGENIAKLFLAEALADDKGTTREKQSFPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9T7</accession>
    <name>A0A0D8Y9T7_DICVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9T7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9T7"/>
    <dbReference type="OrthoDB" id="5874817at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="964" mass="108443" checksum="1CDBBEC3892C5889" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Y1</accession>
    <name>A0A0D8Y9Y1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Y1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9Y1"/>
    <dbReference type="OrthoDB" id="5863415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023963503" description="Leishmanolysin-like peptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="37618" checksum="5F4EFEF917F8B5B4" modified="2015-05-27" version="1">MCDYEAAMLFLLIVPLVFGCNEISLNKQDVRYGIVGRHEDGNVLSNARVKRNAVWNYIRIEIFYDDSLKTFSDQKQVLLKELIEESRDYFSNTLMVDQEYWMQIEPECDGNRYKDVLDDAICENDCLPKCGDAVAPANVKMFSKCTCMGKKCPTDWSQYEGKLYNTDFVLFVTINQESCSSQTMAFASTCSLSLDTKRPISGFINICPDMFNAMKFNDKSRWSSTIKHELTHSLVFASSHFERFPGVTQVLQNDPITIIPGVVEKFTRTDWEVAGGIIKHDVYMIVTPRVRQEARKHFDCDSLEGAELESQGGTGTAGSHWEKRLFEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAA0</accession>
    <name>A0A0D8YAA0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal ion transporter, metal ion transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
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            <begin position="48"/>
            <end position="66"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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            <begin position="228"/>
            <end position="255"/>
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        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
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        </source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KJH52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="50919" checksum="01219074A7ED9E28" modified="2015-05-27" version="1">MAEVAYSYYPKCPRLILWIMVELAIIASDMQEVIGTAISLYLLSDGRIPLWAGVLITISDTFTFLFLERYGVRKFEAFFAFLIALMAIAFGFEFVKGKPNTSLLFTGMVVPWCRNCGTTQFLQGVSIIGAVIMPHNLYLHSALVKSRNIDRTRLAKVDEANKYYFIESFFALFCSFWINVLVVAVFAEGLHNKTNADVRKNCYTIDNHMPDFYKDIFDNSTELANVDIFHAGVFLGCTFGVAALYVWAIGVLAAGQSSTMTGTYAGQFSMEVDKSLAMAPTLLVTIFSGGIRHITGLNDFLNCMQMIQLPFAIIPMLTFVSDKRVMFDFKMSRLQKIFSLTISLIVLAINFFFLYDWMNTTFGFDAITAVVSILLATIYSMTIIYLFYYCFVAMEICRQLKWRCFPEPHYCDFDAPWLTTTQVQKCYVNPTIIVDEGNNPKYFHSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAC4</accession>
    <name>A0A0D8YAC4_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_00813</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="80255" checksum="71AC73D1B7DE480D" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAC7</accession>
    <name>A0A0D8YAC7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">microtubule-severing ATPase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_02278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YAC7"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="141"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="42350" checksum="5A3ED1E9218BF8F4" modified="2015-05-27" version="1">MDITPDKRKAVAEAKERMVGYQRSAKERFVTLMNKMKGSSEPVRSSLVPGPSSAASSSRGGRVRRVIPNRTGNSCPTIPTREQLLKGVDAKFGERLLDEVLVRTGVRLSDVAGCEAAKEALEEAVVLPALNPSLFSGLRQPVKGILLFGPPGNGKTLLAKAVASESRQVFFNISASSLTSKWVGDAEKTIRCLFQIAKNAQPAIIFIDEIDSILCDRSEKDTEVSRRMKTEFLLQFDGAASNPDDRVLVIGATNRPYELDDAVLRPIRLRYKVRKEDLRFLCLYLDFIHLKNNKFFDFWWIASRTDDYSNSDLVALCKEAAMVPVRSIDKEKLATCDESKLRNLKCSDFDKALRVIRPSSNRRNLQSLDEFARRCGQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAD5</accession>
    <name>A0A0D8YAD5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquinone biosynthesis protein COQ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YAD5"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="132" mass="14858" checksum="E7477A787B92CD3A" modified="2015-05-27" version="1">MWTEEKKHLDIMDRLAAKHDISHSIFSPIFSVVAYGLGVFSALLGKETAMACTVAVEELIGQHYNNQLKELIADDPEVHKELLDLLTKLRDDELNHHDTAIKYGGLEAPQFDIMKRIIQFGCKGAIKIAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCB4</accession>
    <name>A0A0D8YCB4_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCB4"/>
    <dbReference type="STRING" id="29172.A0A0D8YCB4"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14485" checksum="E48345DD33DFB2D0" modified="2015-05-27" version="1">MDRHYRLPPFSPSAFHSRFFDDFDFDRPFYRPYWLDQTMMRSHKIGEGIDVRDDEKEYAVSVDVSQFEPEELKVCLNSIRSLLRHIENVCTADLICCVIFAFIFKKTSTLKVTQRFVTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEB2</accession>
    <name>A0A0D8YEB2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEB2"/>
    <dbReference type="STRING" id="29172.A0A0D8YEB2"/>
    <dbReference type="OrthoDB" id="6618337at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21524:SF5">
        <property type="entry name" value="SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="9">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH52966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13583" checksum="5C734751A66C9897" modified="2015-05-27" version="1">MLAALYPGEPIRNVLAEHGFEGITSDTDSKSELGSIDDSSSELLSPIPNTSAVTLPVTQFRRHRSRWRRVLRTALPLQAMLVLLLGAACLVPHCDDEYCCQLLNNFARSFDPSIQFVNGPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8D4</accession>
    <name>A0A0D8X8D4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SecA wing/scaffold domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_14045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecA family.</text>
    </comment>
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    </evidence>
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    </evidence>
    <sequence length="359" mass="41612" checksum="BF29002629A8E5B0" modified="2015-05-27" version="1" fragment="single">ESRRTDNQLRGHSGRQGDPGLSKFFLLLEDDLMRIFGSDRMRSFLQKVGLKNNEAIHHLWINKALEKAQKKVEARNYDVRKSLLKFDDVINSQRKVFFKQRSHILESIVHSGCYEDYVEDIAKEFHTKYGMILDREDLAKFVNKQEALDYVNDKVQGFFTERERYFNSQQTTNLWNTVVKQVMIMTLDHLWREHFSILECLRQSINLRAMGQKDPLSEFKREAFLMFESVLKKWKELTVHRLAYFKLVDNQEIDIYFTNLASLIAMSTLISATVTNSSAITPVDNKEFGVDDKDNKESTLVIGVTPYATRPIPFVTFQINKPPTYIIGFSKSLILQLRGSVDGEIVVEAAISSTTEMMP</sequence>
</entry>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="108"/>
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        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="293" mass="31803" checksum="AE6E0C55E9B15D01" modified="2015-05-27" version="1">MSREIVTIIVVGIQPKRQKLDKQGAPSSVTYSDTTTVEMKPNPAMLPPLPLRPKPATTPSTVRPKATITPPSTLKPKPAITPPLTLKRRPATTPLTLEPKYTVQQTDLKPQASAHRVAPNAATVSVRDSETREEKPQVVPVSQAPTSNLYMVRASTPRRNVAATIPTGMTSMVPNPYVSPSSLPHIHPYCTGQQTALPYAVANPYVVYPSNASAFPPDSSSMGRPPINYIPGVVPNPYGQQPSGEVEKFGEVAWPRQKAVIVIFALCEDNTVAVNPQSHCYCQFRNEAENLVK</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
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    </feature>
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            <begin position="61"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="94" mass="10205" checksum="85C105234F74D1C9" modified="2015-05-27" version="1">MGGRDGVGGVVSHLRCAVTPTLTPSAVSTSSMPNVTRSASKIRKDDKTTSEGATVNSSKRNSLEDRESSKLTLDDELFDILYAFRYTVFKIFGE</sequence>
</entry>
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    <accession>A0A0D8X8V3</accession>
    <name>A0A0D8X8V3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716939">
        <property type="protein sequence ID" value="KJH40988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8V3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7861" checksum="74BCC14BA4F9AE7D" modified="2015-05-27" version="1">MKKIIEQPQHLTKFVTLVCNHQSDSGEIMHFFANEQRKSMTWIIYLTAPLHCFMKSLSLHATCFSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9P8</accession>
    <name>A0A0D8X9P8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tumor protein p53-inducible protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p53-induced gene 11 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_13700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31584">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="67"/>
            <end position="87"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="20805" checksum="543317CCD908EFF2" modified="2015-05-27" version="1">MIDEKHMITRKQSASDLQSRLKTRKLLGVGELARDNGDIYKSKGLIAPHLALRLDYGLEIKSDDSVFITRMYGACLICYGILFRTIISQRENRSEIATLLLVTALLQTLQLSVALVFGQRHEFPCFIRAVGIVGNLIYNNFVDSQGGVYRHLQHVIEDCSVLSTSCRSNDLSTEKSASTIKPIKSE</sequence>
</entry>
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        <name evidence="14" type="ORF">DICVIV_12669</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
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    <dbReference type="EMBL" id="KN716844">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
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        <property type="entry name" value="PDF RECEPTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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        <property type="match status" value="2"/>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="487" mass="55873" checksum="96CBC7556B11F8B2" modified="2015-05-27" version="1">MDAQRVPWNYSLPNGNVAITMEACFQMLSEQGIPPIPDQTDGSLWCNATYDTVLCWPPTPANTSVVLPCPPLKGLDPTRQIVKSCDRYGRWAGKTEGVYENPWGWTNFTVCFKMDYENVKIAQEVARNARKLEFVGLGLSLVSLIVSIAIFSYFRRLRVFRNMLHLHLMIAILMVVVIRLVLYIDLILLEPFVCEAMYSLLEYFKTVAFGWMFLEGLHLHNQLVLTVFNSEPRLTRYLLAGYERCLGSYYLEPEFWILDGPRMAELVVNLFFICNVIRVLWSKVRESHSTSELDKMKKSVKAALMLIPLLGIPNIMQTIPFAPTRDNITIFAIWTYLASFTYMYQGLMITIIYCFTNKEKQNLIKVNMVLKAFYDRYRLQHTTQNELRRGSRSAASHYQTRNGQVTAETISMDNNNDLSISPYSQRSKKGSGDSTVKLMLSISHCGEEIVNNNGYPTVDERTPLKPHQCDCEDEIRVKTILNGQHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA12</accession>
    <name>A0A0D8XA12_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716831">
        <property type="protein sequence ID" value="KJH41403.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="130" mass="15030" checksum="E218E2A4D41A236F" modified="2015-05-27" version="1">MENEWMPPLLMNTDEPLSQPQPIVFVIYSIPAMLLLAVIFIVKWRPCYEFVGIRHCLRWYLHCCSKENLKEMQSFDRERILTIDAESLASTALHDSPRLSLKQNSFELWSATGGERQPSISTLNDLSNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAK1</accession>
    <name>A0A0D8XAK1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716790">
        <property type="protein sequence ID" value="KJH41603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAK1"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335734" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="28965" checksum="9B5787FE0CFBC86A" modified="2015-05-27" version="1">MMMCISYTMLLLLLAVVPLHGQIESCGNKTKDAYRRYLLGAHNRVRDVQNPMMMKQDNFTNVGCSLKRCPSSLNTNTIVMVCFYEKPATTTTTATPAEEATTTATVSSSYTSTNKSTTCTMNKKTRERILSSYGNLMKSKTSEKPKWSCELEKMAKETVENCPQKLENTSSASSNSQSTDLNVQVRLSAFFVKKILHQWKKSSITRRKLCHTLAAHLKTALILMTERWLAWHVSMVNLEEVCFCYTNGGTAALNLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB81</accession>
    <name>A0A0D8XB81_DICVI</name>
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        <submittedName>
            <fullName evidence="3">NifU-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DICVIV_12150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
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    <dbReference type="EMBL" id="KN716745">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB81"/>
    <dbReference type="STRING" id="29172.A0A0D8XB81"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
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        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13720" checksum="BB17A75AFE832372" modified="2015-05-27" version="1">MRAEILSKIANFIESERPIINSSESSVVFEDTAIHDDDDDTVAMIKELIESRVRPMVQEDGGDVNYGSCTGCPSSSVTLKSGIQNMLQFYVPEVKEVCEVKDESDDLIQRELEKFETGRGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBZ9</accession>
    <name>A0A0D8XBZ9_DICVI</name>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="11" type="ORF">DICVIV_12853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="KJH41169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
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            <end position="138"/>
        </location>
    </feature>
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        <location>
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            <end position="166"/>
        </location>
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            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="452"/>
        </location>
    </feature>
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            <end position="212"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="452" mass="50920" checksum="0B744E0375374048" modified="2015-05-27" version="1">MEIQAHLMHHNPYDIVKAEEPSTPPKTKATLCSSTDMLFSVSNFNIQSNFCPPVNNNHDPLNNNHVKINSNGRTLAADRKRPYPCNLCTSRFGSKMELEEHQNSHTGMKPFECDVCKARFNRRSTLWNHKRIHSDAKPFVCTVCQMTFKWKNSLKCHKEMHMRKNESTPHIDNDLRQLTYATAAKRKLMMDQEEQGNPATSSASSIHSQPLITTTTPKKKSNKSSPNHAIGAIHLNPITQPLQASALIPPSDHQLDLDTSSLDTLVNSNNNLLMHIYNSEVDPTLSSRHTNSMLNSIDDNMLNSQLLGDIKNESSLSGTTTTAPINVHLPMQLNMLNFRPINAQQLPSVHHLTSTSLPVSVPMDYSIHNETPNVAHPQYIVTTQPDMMLPQGIGYQHHGLDQCVILTTGHDYVPNFDYPMIGNYQMQTEQHEAAQSAHDSNNDEKIVPYEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE44</accession>
    <name>A0A0D8XE44_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">VMA21-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <begin position="54"/>
            <end position="76"/>
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        <location>
            <begin position="216"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="416" mass="47385" checksum="AD7BA702ECCD0F1C" modified="2015-05-27" version="1">MDDLIPNLRDERVQGAVKNLLVYSIVILLVPLGSMFLLKQFLFEDIFGYTSDDALTFSAVIAVILVHVVLCLWLFAANPPVYLGFCHDLETDNLYRLRRIFLPLGKIGGKPSWLNPKILPSTTDLQCGVCKKAMCFLIQIYATHEDDPSSAFHRALFVFICRDQRCSKRNDATNMAVFRCCLPRENPFYSFDGPLDPDLVGNTSDPYLPVDAPNLCEICGCYASKKCGRCGVVWYCCRDHQALDWTSLHKDGCGTNTLSEALPANPSNSFLFKEYGIEMDQEYVPAKFFENGDDDEDDDECFNGNCDEADDVERRNMIEFERYLATNKVKNERFEIEDIEAAVSDQPNDLRFERRYLDLNCEQILRYQRSGNPLWATDRAPTLNEAPPCEKCGAARHFEFQLMPRLLSLIDVDQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE97</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="14066" checksum="B3A7925BFE5E5950" modified="2015-05-27" version="1">MRKSNSTNFNSSKQSKRRTEKGLDKELWKMQLTTSTSKKDDNGTNRAPNETTEVSSTSSRGIESCVRNVPNTAYKWKSKRPIVVKRRFSPTHESSTSDSQRSSNQSCRSPPRNDSLGKYYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEC7</accession>
    <name>A0A0D8XEC7_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Brf1 TBP-binding domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_12006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11143" checksum="EB7DDE46B4AF5315" modified="2015-05-27" version="1">MDSVYRVADSDEEGSTSHDYSKYAPSLHSLGITQKTTCSSAAYVAVSPLPTQDLPDGSLDLTGIDDEEIDTYILTASESAMKERFWMKLNGEYLKEIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFK8</accession>
    <name>A0A0D8XFK8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_10609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="KN716565">
        <property type="protein sequence ID" value="KJH43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFK8"/>
    <dbReference type="STRING" id="29172.A0A0D8XFK8"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF6">
        <property type="entry name" value="D-ASPARTATE OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="313" mass="35592" checksum="C196A6BBEDFD4630" modified="2015-05-27" version="1">MVFINGDADQTRLYGNETFIHLAELWRKFGGTSGVQLLSGHILSENLDSLIEQERAYADIVYNFHFLTKRELKSQFVLNTTEYCIVFLSKSSAIHYTAFTSEGAKYCPWLKKKLLCRGVQFVQRRIHSLDELADEGFPIVVNCAGLDGARLAGDDSKVYPIRGILLKVEAPWQKHFLMRDFITFTIPTDSWTNIEQIVYSIDAVYVGTVKEDHKDNRNITDEEIRELFNRYVELQPSFQNVKIVDHFVGIRPGRPDVRVEAETRITKNGTTYKVVHNYGHGGSGFSIGWGTALHASALVLDSSVDRYERAMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG64</accession>
    <name>A0A0D8XG64_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716543">
        <property type="protein sequence ID" value="KJH43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG64"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="21975" checksum="2FCB46DF6A871C27" modified="2015-05-27" version="1">MKSRPYPAQPPHYCGGNVQIERSGDFAGNKPSIKDFVSDNLTHCMEKVQQQSSEPLFVIIDNYIRTKPRRILLAWGIGILAAAIGTHYVVKKYRQRPKRTVRACSSSTRELIGKTRYFVCISKLSEVQVSSRVTPMKIAKADVPSTSTMAHQPTTQTVLISKPAEKKSVVEIDRGSVTRLVKPIDAKRREKHTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGC9</accession>
    <name>A0A0D8XGC9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716532">
        <property type="protein sequence ID" value="KJH43705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGC9"/>
    <dbReference type="STRING" id="29172.A0A0D8XGC9"/>
    <dbReference type="OrthoDB" id="5843820at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="210"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="309" mass="35304" checksum="63A312CF85180889" modified="2015-05-27" version="1">MDSFATKEGAIALNINNRVSTRSTRKSKSKVPTPKKLIDSLTGKVPSRKLGEGVISAHKELIRESPTFFAFFKEENTSKNLKPNEVFLYDWSRVVLSDDPDYYHASYVDGCVKAQQYILAQAPFNSTTQTDFYRMINQIHPDSIVLMDSESSPDMKFVLPQNYSGNTIPVKAEDEQQKGDGYTTRNLLVNKNKIKLYFIDGWKDDAEPPKDFVNVYEKIRRSIGLDSKNILILVCKDGCSRSSLYCLLDIEAERFRLKGRMKFGDTVRHIRYQRSNCFDTQEQFAMGISLIMILAKKYQDKGDASFSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGR6</accession>
    <name>A0A0D8XGR6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716608">
        <property type="protein sequence ID" value="KJH42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XGR6"/>
    <dbReference type="OrthoDB" id="5810237at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF170">
        <property type="entry name" value="T-BOX PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16580" checksum="D606A5178B78EBC2" modified="2015-05-27" version="1">MHKYIPVLTIFEIAQSETPFLSAPTSQPPKQIARIRLPQTEFIAVTAYQNSTITQLKIEHNPFAKGFRDGGERKRSTPESSTTTSPKRIYSPQNYPALLEKPTPVVTTPTPLPVPPPMWHGFYPTYWNPYSYILNPFFTRFGAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH34</accession>
    <name>A0A0D8XH34_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716597">
        <property type="protein sequence ID" value="KJH43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH34"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13693" checksum="B4EE15FB62C05E3B" modified="2015-05-27" version="1">MTKSKAQSKKTEHHRYKLVFQYSNRKRLECLYWVWSNDDEYGAFSRIQKMPYGKMPCNNCTVLSTCKQKECCHLLSRFFVKSSSYPTLQDISVNNIFNTSLFMANCSTTVTSLATMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH96</accession>
    <name>A0A0D8XH96_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase, alpha/beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716590">
        <property type="protein sequence ID" value="KJH43124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH96"/>
    <dbReference type="STRING" id="29172.A0A0D8XH96"/>
    <dbReference type="ESTHER" id="dicvi-a0a0d8xh96">
        <property type="family name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="119"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="309"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="48575" checksum="A8BF79AB156263F5" modified="2015-05-27" version="1">MKCKDTQKLKWLTFICIPFLVMLLVIYRPLPVGLTKKPMDRFLIHFFESFLRITYYWPSRFLTKPTTIVWWTRTVLNTLAPILGPYWRDSSLHTEDRVFRGVLVRVYTPRKNSSINGAVVFIHGGGFAIGNIYIYDSLTWRIAKMLNVVLVSIEYRLSPETPFPGGLNDCENALEYFLEIAEMEYGVDPRKVILMGDSAGGNLVAAITQRRRDFNNKPDILGQVLIYPLLQLADFQSVSYRFFQKHLHGTSFVDPESIVYYYMLYAGINMEKYSHVVKHVLVNGHVAGHLVDRVSKILAYNSSSHFNYNNGTLMEQKQVAYSAEAQELLAPFITNPMFSPLMQENLSNLPKAFIMTCEYDVLRDEGIMYAERLKAAGVNTETRNYKNGFHAMLNFHNKIEEAAESLNDITLWTINTFISKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI36</accession>
    <name>A0A0D8XI36_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716563">
        <property type="protein sequence ID" value="KJH43397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI36"/>
    <dbReference type="STRING" id="29172.A0A0D8XI36"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="239" mass="27847" checksum="D15F65C766E13977" modified="2015-05-27" version="1">MINFETDHRTFGECDIGWLARENGMCYRKVEAQPKVGWADAQDQCNQMQANLASIHDKNDYDYMSTQWLVPKRCDDSNMPSDKPNFSTLRDQCTEFFGQIPSHSWIGYTDADDEGALMGINSKSNTIWPQPILPDNNDERDCLYLDYSMPVEEPYRIADCRTKQSFICQKRNNWSTFVVGPQHERVRTAFFKKQCQNRIHSTESNRLVRGIDTHSQFDHSQPKDALYARINYQDGKHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ46</accession>
    <name>A0A0D8XJ46_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10224</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
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        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
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        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="KN716528">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Aconitase/IPM_isomerase"/>
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        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
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        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
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        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ACONITASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="63"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="796" mass="86898" checksum="73140174F235030C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKE5</accession>
    <name>A0A0D8XKE5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716626">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5877402at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="143"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="435" mass="48836" checksum="607951CB5030379E" modified="2015-05-27" version="1">MLILLLLLPLSAAQNPYGPSQLDQYARLINSGNLGGFGSFQHALAEGTARGFGDLNPFPSIAGLPPLPLTHEEVIKQLTSTPRTAPTRATAIPTTPSTYPGGIYAINRMVELPPMPENRIHGTFDDDGVFHPYNEKKTEQIIRNQIQGTKIRRFSQTGRDNTESNAQENTNKGFRHEDGTADDKVSLDAKEHQLTDRNKKSPKPRQNSTKDKQRLRHRQVKYYDSDAKLERGGTSDVPRQPRYPPFVFRPKPPPVQREPEYNNLLAEIEEYDDFLEEQRLYLSRYPKASVPNPYHELPPGQLPSAGAYSMINLGITLQNNQKHDESSNKAIIKLTNNVIRHYDIPPPKRISFENDNADSTQDWSLSPSSSQPSSTRVENVNPHIDNPLLNFFNLFSIPHAYAMAAPQLNIDTKASLTTTTTSPVYSMTLLLSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKV2</accession>
    <name>A0A0D8XKV2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716604">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0D8XMD0</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="268"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="382" mass="41569" checksum="36B5FBBADED16427" modified="2015-05-27" version="1">MEMNHGVTIQFQLRGYSNPQSALPNGWTCICPLGHSCNYLKSPPTCYFGFTFIISAPDTSVRHLATDFITLDINGQLPTSQRNGWDQNYVVQLPSKPVSKCIFPLFICCISAIDIFVHHLGPVINQADGSLVSVETLTHVDTFVVPLSDAVPAVGGVQSMAQQHAYQGKLLGTTLHISYSISCTGNLIGPDCDLTCTPSSISFSVASCRSNATGFFYICNYQSGGQVDNCNSCPWGVKENTYCQDEQGGVLDPYNAGVVDTGYRTATIVLSIITFILLLLLISAVVLICILRRRQKPTEKEFMTFSRNGGTASTRPLLSTPYRVDQPSALQRSQPPSLDARPAKSSMRKAMSPPLGQLNDSRDTSLNSELPLISRPSRSEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMF3</accession>
    <name>A0A0D8XMF3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exocyst complex component 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716435">
        <property type="protein sequence ID" value="KJH44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMF3"/>
    <dbReference type="STRING" id="29172.A0A0D8XMF3"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14683">
        <property type="entry name" value="PH-EXOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="830" mass="95206" checksum="2576376AE511CCFF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMP0</accession>
    <name>A0A0D8XMP0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 61 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716429">
        <property type="protein sequence ID" value="KJH45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMP0"/>
    <dbReference type="STRING" id="29172.A0A0D8XMP0"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24434" checksum="AC4EAACEBB28F835" modified="2015-05-27" version="1">MSLLDCFINHSLSDIANGLLKALEDIPNIIVKVVDYNGHVPFLSQLTSTYNSDVFIGMHGAGLTHLLFLPDWAAIMELHVPFLSQLTSTYNSDVFIGMHGAGLTHLLFLPDWAAIMELYNCGDQHCYRDLARLRGVKYFTWNPDKEHLIYPESTAPKSGSRESHRKFMNYRFDPLEFRHRVELMVEFVRRHPKFVEERRRLRRVLKSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNQ1</accession>
    <name>A0A0D8XNQ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716411">
        <property type="protein sequence ID" value="KJH45367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNQ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XNQ1"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="241"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="362" mass="41731" checksum="893ECC6B652B95BD" modified="2015-05-27" version="1">MLEFVIRRKFWIKDFIPNAYHDDVVDDALGQQKKNEVEMKSGSSTSADNRLTWTQSLITKRPIRALAKEFAAHKKIKPIDFTTEAYEKNDAKNRYNDIVCIDATRVVLKDRSPENDYIHASWMTMPTDRSIFVTQGPLQEYVGDFWHMIVTEKSKVIVMLCNFNEGKHEKCCFYLPKEKSDIGSYGCYIVSVKSSKPDPFEGIKHTEFDVRWSDNKTFMVHHIAYFDWPDHTAPLDPKPTVGAFKLARTLAHGNPITVHCSAGIGRSATFIAIDYAAQKIRDNAEASMIDVIKDLRSQRYQAIQSAIQYVFLHVCLLEYFAEENAKIRDSKFNDYMESYASMIKRYNKKVEAKQREQSKAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNU1</accession>
    <name>A0A0D8XNU1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <source>
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    <sequence length="121" mass="13385" checksum="86A037BC654C6587" modified="2015-05-27" version="1">MLFDGRRLLEQKQTTVNPSVAYKSSIDTSSKLSSSSGSSSFGSSSSDATFSESFLFHVSPLRLYRCHIVIEMFDHNSAGETVPVGHCVIGRMGDSTGHAHWIQMLKKHGLPICMWHRLAEN</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        <name evidence="1" type="ORF">DICVIV_06910</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716324">
        <property type="protein sequence ID" value="KJH47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQS5"/>
    <dbReference type="STRING" id="29172.A0A0D8XQS5"/>
    <dbReference type="OrthoDB" id="5810331at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF37">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="25286" checksum="E775339F331818A0" modified="2015-05-27" version="1">MILSIAMRRSQDVLKWISYFLTSLAFTEGFIKRNHLFEVDVKNSPYYKDGIFNIPISDEHGNALYKHWVDQAFSSLMAAIATKKLQSMSTTERTRHHNCARKAKNLQAHAKCVSELLDVSAKVAKRNRWVKLLNKKRQRSLVNHSVISQIKSTPVIHARTSERNSLLRNRFHLRHKRTVASMSSYNITEEKDGSIFGRLARQLMKTVLTLKNKKTHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQT0</accession>
    <name>A0A0D8XQT0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_07059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQT0"/>
    <dbReference type="STRING" id="29172.A0A0D8XQT0"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="1">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42749" checksum="7DC92532D82112D3" modified="2015-05-27" version="1">MDSRESGPHLIKAAQAGVSLMSVPYEDHGLLTTPQLHFIVRCKNDPNFGLAKEIGYYTKISDAFKELLKLGSETEQSSYSPYLVLDCSNGVGAMKMRMLCRFIPETELKIEFRNENGELNCKFICLVSAILTKCGADYVKIEQMLPENFDDVDINTKCASLDGDADRLVYFRRKTKDSKKALLLDGDRIAVLIAKYVKEALNVAGITNLTVGVVQTAYANGNSTKFLREVVGITPVFVPTGVKHLHHAAVQFDIGIYFEANGHGTVVVGDALADLLVVESLLRWYGFSVIDWERQFYADAPSVQIKVPVADRSIFKTTYDETILIEPEGVQLKIDSLVEQYSEARAFVRPSGTENVVRIYAETQLADEAEALAESIAVIIRDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRJ4</accession>
    <name>A0A0D8XRJ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRJ4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="190" mass="21671" checksum="83D1B5A976EF38AF" modified="2015-05-27" version="1">MGSDSDFEDRLVIVEDEDEPEVQLSKNESDGENESDSEYEDRLMIAEDQEEPEVQLSRNESGVENESDSDFERRSVIVEDQEETEVQLSKNESGDGIESESDSEDSSESDEDEDEVVIVTALVTRRTKLSRVLPLLLVLNRRRSYGARAKQSRYIIPRGEREHFALFAEECDVFTALNRAVTYGFDAVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRN1</accession>
    <name>A0A0D8XRN1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716354">
        <property type="protein sequence ID" value="KJH46399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRN1"/>
    <dbReference type="STRING" id="29172.A0A0D8XRN1"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="2">
        <location>
            <begin position="348"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140635" checksum="1EC9543723DC8C92" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRV7</accession>
    <name>A0A0D8XRV7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CHY zinc finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716348">
        <property type="protein sequence ID" value="KJH46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRV7"/>
    <dbReference type="STRING" id="29172.A0A0D8XRV7"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="68615" checksum="9530522F7A46A4CB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRX7</accession>
    <name>A0A0D8XRX7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716349">
        <property type="protein sequence ID" value="KJH46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRX7"/>
    <dbReference type="STRING" id="29172.A0A0D8XRX7"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="182" mass="20952" checksum="F932C10DFE4E342F" modified="2015-05-27" version="1">MTGNFGSPIRVNKWDGPTVKNTLDDAVKQILNDKIGWKEYYSLMDGRLLISFIAICFSATALVYDYIHPFPKSKVVLAVCSVTYFILMGILQLYQWYIEKRTFYQAEESDGKQKRMWKWSSELKSYDDKYTLSAEFSKESRSGQGKITKSIGAYINEAGEIVTPLLKKDVDHLYENLLKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS71</accession>
    <name>A0A0D8XS71_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS71"/>
    <dbReference type="STRING" id="29172.A0A0D8XS71"/>
    <dbReference type="OrthoDB" id="5798901at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF44">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="21945" checksum="7949C85E2740FB35" modified="2015-05-27" version="1">MEQLLYSSAVYPRKLINGLHFLIPDDKSFLCMPAEFHTDDPIDNLLAEMKVAFTCAALSITVTICCNAFRTQSVAVQGKLVCGNHPAANVHVKLLDEDHGDPDDVLDYVLTKSDGIFNLSGSASELTPIDPELRIYHDCNDYGKPCQRQWIIRIPSKYIYSGIEPDEAMNLGIMNLEASRSILSNWRVKIKIASTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSW4</accession>
    <name>A0A0D8XSW4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pep3/Vps18 RING C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716329">
        <property type="protein sequence ID" value="KJH46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSW4"/>
    <dbReference type="STRING" id="29172.A0A0D8XSW4"/>
    <dbReference type="OrthoDB" id="5852971at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="139"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="516" mass="59550" checksum="7AECB57313CEE944" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT00</accession>
    <name>A0A0D8XT00_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT00"/>
    <dbReference type="STRING" id="29172.A0A0D8XT00"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="2">
        <location>
            <begin position="181"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="358" mass="40965" checksum="6ACA79AFC4910137" modified="2015-05-27" version="1">MEWFLPTSQRLENTTFMDGDIHAQLHMHPVSLLLRSFVALSTIALLVQIVLYHINDIVLDLVDCGADDWRVVVTIDRAIQFCTEFLLCAICPLPGTGSMYWSFIETARNMQSSQGRSFYIKEVPIDVPLSILMLSRVYLFARFMDASTRTLAALNRIQVNFSFVLKTVLDQQPILFLTTFTIIFWIVTSWTFVQCERFGQADQDVPSILYSNALWFIAITFMLNGYGDIVPQTHAGRIIAILVGVVGAIISSILIAVISRNILLSQGQRNVNNFMHDSKLTREHKNAAAKNEMRVFSENNSANSQQVTRLVAEMHFSMQRLISAQEEMKTQIEVLQRAVRNHYANTHQWLEYDRYSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU15</accession>
    <name>A0A0D8XU15_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Utp13 specific WD40 associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716382">
        <property type="protein sequence ID" value="KJH45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU15"/>
    <dbReference type="STRING" id="29172.A0A0D8XU15"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="530"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="580"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="633"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="PNO1 second type I KH" evidence="9">
        <location>
            <begin position="923"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="857"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113012" checksum="A5E6F2A3402ED156" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU29</accession>
    <name>A0A0D8XU29_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716315">
        <property type="protein sequence ID" value="KJH47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU29"/>
    <dbReference type="STRING" id="29172.A0A0D8XU29"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="16705" checksum="60F8F8FB5D8D57BA" modified="2015-05-27" version="1">MEARKAANDTTLASVASNLEPIGRIQMRTRRTLRGHLAKIYAMHWASDSRNLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGSFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMTWFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUU5</accession>
    <name>A0A0D8XUU5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUU5"/>
    <dbReference type="STRING" id="29172.A0A0D8XUU5"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="396" mass="44771" checksum="BBD3E9FAE6A29995" modified="2015-05-27" version="1">MLRFFLLKDVLGDINTKLTAVNDELSTKQMAENVNSSRPVQQAQYCGPYKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVGNESIFTQRTFTILYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDDRNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRNLLEKVKKGMFHIPHFVPSDVQGLLRAMIEVDPAKRYSLADVFRHPWVVGTTKNEPELELPMSQVVQTHVIPSEESIDPDVFRHMNSLGHNTEKMVYFLLLDRKRRRPAHEDETEIVLRGSAQHNDPPRKRTDSARTNRYAVGSIADGSPINPRKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUZ9</accession>
    <name>A0A0D8XUZ9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome complex subunit dss-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUZ9"/>
    <dbReference type="STRING" id="29172.A0A0D8XUZ9"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="165"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="46964" checksum="2DCBB8A60DB94073" modified="2015-05-27" version="1">MIIRFHPSASSLLSSLVVSTPFGTQRAFVHHHMEREDLARFLGIKRSNKARSNRNTHVNEKIFRKLRGKKTITMQLPDDEERRRHDSLTPSQLRIELLRKGINPYKEVQPRIWQESQISIQSFYGVIDPFVTLEETLPIFSGGVEGMKLKGEELKQRLLHRYHNWRNGTSRIRKKEGFEKFDARAFGSTADLIYEQAHQALMNRDKTALHKYITEHAYSKMWPDVENGSVVWDLVERLEPSTVVSVRCLDYPYKSGNDIAQLTVRMHSKQKLAIYDRFGHLLLGSETEPREVVEYVVFENHIAVIDGTWRLHDKVYPKWVAPKQGVLTTYALVPKKENVNEKIKKAIDDEEFEEFPVQEWAEKAQDGDDDEVNVWEDNWDDETHESDFSKQLKEELSKSGAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV95</accession>
    <name>A0A0D8XV95_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MT-A70 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716296">
        <property type="protein sequence ID" value="KJH47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV95"/>
    <dbReference type="STRING" id="29172.A0A0D8XV95"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14532" checksum="67F708A32E657863" modified="2015-05-27" version="1">MRYETSNGAPVVYYVPPKATFHIGSASDVCNFSAINDEMFDLIIMDPPWENLTVKRQKSYVMNESILFQINMNNLAPSGLAVVWITNRKGIEHSLAVHFRRWGLKRLATFYWLKDYRGNTNTEGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWE2</accession>
    <name>A0A0D8XWE2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWE2"/>
    <dbReference type="STRING" id="29172.A0A0D8XWE2"/>
    <dbReference type="OrthoDB" id="5857313at2759"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="269" mass="30780" checksum="8178B83FDEA1B72E" modified="2015-05-27" version="1">MFFFGIFSACHLRHSISSNVIIRRNCFKNPQAAYEIGTELVEHRKRIDARENNWGSPQPAQFMNKIFDQFYRYSLAVIEIGPYAAVCNQRNPHITFLQEYFRQFRNESQPFVLGGTIYENHDLATGRYTIVDDLHIVPGAKLTIGSGSILEFHNGVGMLVQGELLKSDFSSSEKQVVFTSKPFVLPKNKVIRLVDDNGNEEVLEGRLEVFVDGIWGTVCNRSWTAKLAQLSCNQLGLVADPEFFENWRIFRSKGELPMVMDSIRCEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWG7</accession>
    <name>A0A0D8XWG7_DICVI</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="10549" checksum="9A2858EC3AD13AAD" modified="2015-05-27" version="1">MDSLPETLLIVLAVAMCAILFCFAIGVLMIFHCYDIKDINIYDLPSVVLEKTRHSMNDSQNSIVSSDSESEGVDKDNGFLKPFRAQFQKSSSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWN7</accession>
    <name>A0A0D8XWN7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XWN7"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF262">
        <property type="entry name" value="CUTICLE COLLAGEN 34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
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        </location>
    </feature>
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            <begin position="144"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="29130" checksum="A24FD1AB115AC7CD" modified="2015-05-27" version="1">MEFEWQHRCKAYRIVAYSAVAFSVVAILGAVTTLPMVYNYVHHVQRTMHSELNFCKISARDIWSEVNTMKISGNRTARQAGYEVSQGVEEANIGGCSACCSGGQPGPAGTPGQPGRPGNPGAKGAPGSPGKPPSQPCNEVSIPPCKPCPAGPPGPPGLPGAPGDAGRDGNPGSASSESGQGPPGPKGPPGPAGNPGQPGAPGSPGKPAVSSSVPGEPGPAGPPGPAGPPGSNGQPGNPGADGQPGPKGPRGNDGQPGAAGNPGAPGNKGEAGSGGEPGICPKYCAIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWT3</accession>
    <name>A0A0D8XWT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UBA/TS-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWT3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWT3"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25025">
        <property type="entry name" value="EF-Ts_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11345" checksum="8CDA405CBCEE0C3E" modified="2015-05-27" version="1">MLRRFNQRMLSVAFTVRTFSSIAPEPSVKIDKEALMKLRKRTGYSYMNCRKAVIQFGPTNLEEAEKWLHERARSEGWSKAVNFRIVVSVVSHDALLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWZ6</accession>
    <name>A0A0D8XWZ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWZ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XWZ6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="120" mass="13101" checksum="FF564061BB0E7267" modified="2015-05-27" version="1">MVTRISGVLRTSDSTGSLASNGSEPTDSGTSSSQPSSPHHPTQEVPPSYTHAPWPYLISSGIYKIKKYINPYIIGSSADLMFTNPPFVGRCNTHDYDCGSSLVNYYKLLTVALYLTIHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX25</accession>
    <name>A0A0D8XX25_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATG1-like MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX25"/>
    <dbReference type="STRING" id="29172.A0A0D8XX25"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATG1-like MIT" evidence="2">
        <location>
            <begin position="201"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="284" mass="31510" checksum="67C8786D91E76278" modified="2015-05-27" version="1">MHSASSKTEAMESCISGGDGTELSMDVVDQSDSLLPSNLSSGNVPILQGSLPRTPVLFPHRDKEEDGDDVLPGALEHETVMEEEHKQILAKLRFVVELVDTLIQVAEQKENPLIAAMSNRKTEPSSAFRRAEQLVVYVRALHMLSSALLLAQRNVASRVLHPSPAVQNVLNVLNDKYHQCLVRSQELASLGLPGQDPAMAVISAERIMYKHAIELCQTAALDELFGNPQLCSQRYQTAYMMLHTLSEQVHSDQDRTVLARYKNAVEKRLRILERQGFVTAVNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXH3</accession>
    <name>A0A0D8XXH3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="KN716322">
        <property type="protein sequence ID" value="KJH47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XXH3"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="364" mass="40797" checksum="CC514E0534CFA850" modified="2015-05-27" version="1">MAWVSRELTGLMADPLARFKKIAAATDERHRVLITGSLGQLGRGLNSVYRYMYGDDCVVMTDIIKAPRNASDITNYYYLDILNQASIERLVVDQRIDTIVHFSALLSAVGEQNVNLSLQINCRGVENILEVARKHRLQVFIPSTIGAFGPTTPRNDVPDSTVQAPTTIYGVSKVTVYAERLGEYYHHKFGVDFRCLRFPGIISATKPGGGTTDYAIEIFYDALNKGRYTCYLGPDTKLPMMYDTDCMASVVQFLAAPRESLTRRTYNVTGFSFTPAEIADAIKKIIPHFEIDYNICNARQSIADSWPRSLNDSEAKKDWGWHVEYGLDETVQVMLALIQREIESNTTISCTSNKPTLDTMKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXU4</accession>
    <name>A0A0D8XXU4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_05276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716262">
        <property type="protein sequence ID" value="KJH48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXU4"/>
    <dbReference type="STRING" id="29172.A0A0D8XXU4"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HCO3TRNSPORT"/>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
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        <source>
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        </source>
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        </source>
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            <dbReference type="Pfam" id="PF07565"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1062" mass="119537" checksum="E60D607A726D92D8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY70</accession>
    <name>A0A0D8XY70_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DICVIV_06602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716313">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
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    </dbReference>
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        <source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="420" mass="46401" checksum="E3BBAA63FFDC1325" modified="2015-05-27" version="1">MGNCISEDAHKGHKDFLKSVKTDPEKQVTSFRVYLHRRNKFIHAWLRISADDVILERSKADIVVWPLQFLRRYGYTSAGVFFFESGRRCPTGEGLHTFQSQNADAIFQLIQSRIQDNINTNNVETLRRNERARSTGPIMGTGVSFRCINPIQRYGRAGVGLEYLSHPSGYNSYHRGSAQRLRNIVIPPPPRPRSVGEGGVPSLPPDSFHPHRHNTFVDQRLVGSIISESTNPSAVDEVSQRRSSGSSLKISGGVFSVPYVNISPQEVFNDEQRSRGVSSSSSQSSMPNTPTRTVFPLRWDTGAGSTNVLCYTKPASPTAPFSPHNPIVNDSILPSGRYVNVAETGGRTLVDRDESNSPRPLNYAEVGLGTEPERVPSRCSSVGQRADTENGAVSYTLIDAEKTRALQVANGERRRNPTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYA3</accession>
    <name>A0A0D8XYA3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYA3"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF150">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8599" checksum="29EC8740A0E4B9B2" modified="2015-05-27" version="1">MTIFGGLMLLGVGRTMPFSLGLPLMDDNVKKNNLPIYFAFMFFVRILGPILGLLIGSKLNEIYYTFDRELTSSDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYI7</accession>
    <name>A0A0D8XYI7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYI7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="16624" checksum="9F49EEC17D071839" modified="2015-05-27" version="1">MIGSSCVQRGHHSETRQRYMRDDKIMRRSYANEEARTNVLACNSNQLGALIGFAKALLRGTKTEKQHCCKRRRKSSSRFLNEAMQILMDREKFITKLGIITKNNNEWVKYSDNKDTVDHQRNNSCQIKKLNSKSVEVEQHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYV4</accession>
    <name>A0A0D8XYV4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1707486at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10967" checksum="56AB1CF882CDCC23" modified="2015-05-27" version="1">MVFILNVTSYANDYAVTRKRKVLAPEDVFQALSIIESDNITAPLMDALGAWKTNKANKSGEAKKRKAEKKNALTQGASNTSVPFSITLSEELRLKNAEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ82</accession>
    <name>A0A0D8XZ82_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ82"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12237" checksum="DF6BADC0C58DDCE7" modified="2015-05-27" version="1">MNCCADSSVDYKLRASFFLRPGILNFSSNTHVNAWTGPLCNEKARVVKIKKNKKIRRECGPVVLLASKLCRINTARLYYSIGTLNELLILFVIEPHTAQADIRSTPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZB6</accession>
    <name>A0A0D8XZB6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Synaptobrevin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Synaptobrevin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_06238</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Synapse</location>
            <location evidence="9">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716297">
        <property type="protein sequence ID" value="KJH47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZB6"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000013">
        <property type="entry name" value="Vesicle-associated membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00080280"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50892"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="12187" checksum="EC53B1F418A0E2DE" modified="2015-05-27" version="1">MESQGDTAIAGAGGSQGPRPSNKRLQQTQAQVDEVVGIMKVNVEKVLERDQKLSQLDDRADALQEGASQFEKSAATLKRKYWWKNIKMMIIMCAITVILIIIIVLWASGK</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <begin position="146"/>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH49527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y065"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="KJH49527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="11116" checksum="9487339A260F01C7" modified="2015-05-27" version="1">MHSLHPGQLRNAAMTSYTLIVLTNIRNLNDCYRIKYYVNGEVMIEVSKCTDEKPLNNVAYITRKYCTGLTTLRCDRDRRFDFIVAHISMTLIFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0C3</accession>
    <name>A0A0D8Y0C3_DICVI</name>
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        <submittedName>
            <fullName evidence="5">KH domain protein</fullName>
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        <name evidence="5" type="ORF">DICVIV_04416</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716234">
        <property type="protein sequence ID" value="KJH49479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y0C3"/>
    <dbReference type="OrthoDB" id="5826393at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
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    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="SMART" id="SM00322"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49479.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="598" mass="67974" checksum="861210FA504FFD36" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1E4</accession>
    <name>A0A0D8Y1E4_DICVI</name>
    <protein>
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        <alternativeName>
            <fullName evidence="14">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ATG7 family.</text>
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        <property type="protein sequence ID" value="KJH48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="631"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="762" mass="85596" checksum="2B8D40C9F5B38098" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1Q9</accession>
    <name>A0A0D8Y1Q9_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Laminin EGF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Laminin/Netrin_ECM"/>
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        <property type="entry name" value="LE_dom"/>
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    </dbReference>
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        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGFLAMININ"/>
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    </dbReference>
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            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="4">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
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            <end position="55"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
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            <end position="62"/>
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    </feature>
    <feature type="disulfide bond" evidence="3">
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            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="16646" checksum="23654C34EC11FC2E" modified="2015-05-27" version="1">MPLIRSHVQHQRNETIESPIIIRGTSQFVKDGHGDIENGCPPCECDIIGSIGEQCDAVSGQCTCKQGVFGKRCNQCRPSYFNFTDAGCQFCHCNIYGSMQDGKCNNVTGKCECRENVDGTMCEKCATGFFNITSGTGCQRKSFWNFLKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1T0</accession>
    <name>A0A0D8Y1T0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716197">
        <property type="protein sequence ID" value="KJH50793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1T0"/>
    <dbReference type="OrthoDB" id="5869826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336319" evidence="2">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="16647" checksum="46F2F3561CE78B98" modified="2015-05-27" version="1">MVVVGFCSVNSTLLLLGQAIIMSGSDIDAKEISAEKQEHGTAETTGDEVAEESRDSAASFDNDEKSYSGSEEKNVESEEGDDEEGGGDEEEGADGAEENGKEGENGHIDSTDTNGNDRKRVSDVGAGEEAESDAPALKKKRSDDEEVGAGDVPAESVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1X0</accession>
    <name>A0A0D8Y1X0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="KN716213">
        <property type="protein sequence ID" value="KJH50167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1X0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1X0"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="265" mass="29556" checksum="3C00CB025B07CE3E" modified="2015-05-27" version="1">MINDRDILSIGNAFVDYLNDTMYMGRTVGRVCNRIRHGRFNFENREIQLPVNSPPHHLHGGPQGIALREWKVVRQVSTSVTFRITSSEADDGYPGDAKIDREWKVVRQVSTSVTFRITSSEADDGYPGDAKIDVTYTVNDLNQLLIEHGANCATSGVLNLTNHSYWNLDGSPSVKDHLLKVEADSYLPIDEDSFPTAYITVKDYAKLSKMKCVGQAMCMSLEQLNSIGGNYSKEDNAIAFNSIVKKDSLPTLSKICEARGPTLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y240</accession>
    <name>A0A0D8Y240_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y240"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14139" checksum="A010704E10AFB696" modified="2015-05-27" version="1">MPQEQSYCGLGLILSTVHDLRLKYLTVDGYTFARCNTREKTSYLNGKSKDLRLKYLTVDGYTFARCNTREKTSYLNGKSKGQEQKCEYIDSSIRTIRLEATGFDKKNAIPNPDPGYGNRVLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2A8</accession>
    <name>A0A0D8Y2A8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2A8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2A8"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="37268" checksum="253887A0A85C43F8" modified="2015-05-27" version="1">MDSREVGASSSQPDVGIPPSVLVLGMAGSGKTSFVQRLTAYLHARKTPPYVINLDPAAAKVPYPANIDIRDTVKYKQVMKEYGLGPNGAIITSLNLMCTRFDQVLEIIRKRASQYSVCLLDTPGQIEAFTWSASGSIITDSLASSHPTIVAYVVDSARATNPTTFMSNMLYACSILYRTKLPFIVIFNKSDIVSPSFARSWMNDFERFDQALEESRSSFMNDLSRSLSLALDEFYSGLKTVSVSSLTGEGMEEFMKMVADCVEQYKIEYVPLYNRLVEEKMKLNEQERQRKSGNIVENLEVLSLHPTMEPTNIERIHIGGVEEENAEDANILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2E1</accession>
    <name>A0A0D8Y2E1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7741 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Hallsworth Pepin K."/>
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        <source>
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        <source>
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        <source>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Q1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Q1"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF251">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="30067" checksum="2BAE0D93DBB03054" modified="2015-05-27" version="1">MTTTGYIGAGLCLFGVLGALVVISQIANDISSLRDEVTVGLDEFRVIVDDTWDRLLILQSPTGRSVNAMPNLFRPKRFVYPGMCNCRENSNGCPAGPPGMPGSPGPRGEEGRPGDDGRPGAKGISLAVTHDIPGGCIQCPPGPPGQPGPDGPVGEQGFPGVVGKAGPPGEDGAPGVEGEAGDQGPLGPQGFDGPTGPDGMPGTVYFPGSTGQPGEPGWAGEPGLPGKAGDPGLDGKPGMPGAPGLPGNTGHDAFPGMPGQIGKPGNPGEDAHYCNCPQRKEQAIAETTNNVGYRKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4S6</accession>
    <name>A0A0D8Y4S6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ufc-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4S6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4S6"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="57"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="404" mass="45025" checksum="D608979C6808289B" modified="2015-05-27" version="1">MSKIRGYIEELRAQMQALTAELNSYAGDCNSMKSTSFGFSREKIDKMSGEVVDTNPYSRLMALKRMGIVKEYEKIRDKTVVIVGIGGVGSVVAEMLTRCGIGKLILFDYDKVELANMNRLFYQPHQSGLSKVEAAKFTLTHINPDVIIETHNYNITTMENFTNFVSRLCHGSLTSGKVDLVLSCVDNFEARMAVNTACNEENQVWMESGVSENAISGHIQYMEPGRTACFACVPPLIVASNIDEKTLKKDGVCAASLPTTMGVISGLLVQNTLKYLLNFGEVSMYVGYNALTDFFPRQEIKPNDQCGDRFCRQRQKEYKAKRASQLIPEIVAPVREEVLHEDNTWGIELVDESKDESSTTKVGNGLEYAYDLPSKSMLEAEEDKQSAGNSRQELASLMSQLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y571</accession>
    <name>A0A0D8Y571_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p21-Rho-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y571"/>
    <dbReference type="STRING" id="29172.A0A0D8Y571"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49691.1"/>
        </source>
    </evidence>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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    <sequence length="100" mass="11381" checksum="F566B3953734E9A5" modified="2015-05-27" version="1">MMRKERRQLLDRCLIDLCREMEVENVLIYLQGKGIFTDAVVDKVLCSGSVTSQRAAVVRAVKSRGDRAFEAFFRALLHARQLHLAELLRPLVDIGVLQTL</sequence>
</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    <sequence length="172" mass="18942" checksum="C9EF123CE6BA34DD" modified="2015-05-27" version="1">MPGLSLHVTTLNFLGTRFRPLSLQLPKPLFPIAGVPLVEHHIDQLAQLPGLSEIVLIGSYSSDLFTDFIGRCQQTYRISIKYLQEQQPLGTAGGLIAQREIVVGDYPEAVFVINGDVCGDLPVDEMVARISSLPEDSCLLLTTEATREQSGNFGNVGLFSLKFCQLSRKYMQ</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    <sequence length="164" mass="19121" checksum="DB13BD427B711F15" modified="2015-05-27" version="1">MYMVVEWTSGGLPWRKYKADNREEVLKMKEEVRDSAEAMGIFFRNCPEREFKRILKYLYELTYFSIPDYNFVYYCIQHACKANNIKPTDPLDWDMSHKFAGPTGPPGDGKMSGITIDDGEEYLGYSKHHHVGSNSACDKIKNTSLRKTNQKQRSFRKTSLQEAR</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
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    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="16974" checksum="AF0C9D15A027DF64" modified="2015-05-27" version="1">MRRPELAAYSSASSIERSSSSLHSLNNLAENIPMSAIEKLYFIIGIGILKEELRDEIYCQLCKQLSSNPSNLSDARGWMLLSLCVRCFTPSPRFIKYLYCFIQQRSSTHPKCSSYMKECLRRTEQNGCRRQPPSYIELQISEVFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA51</accession>
    <name>A0A0D8YA51_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA51"/>
    <dbReference type="STRING" id="29172.A0A0D8YA51"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="238"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="513" mass="58409" checksum="4D21696564C684B0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA60</accession>
    <name>A0A0D8YA60_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA60"/>
    <dbReference type="STRING" id="29172.A0A0D8YA60"/>
    <dbReference type="OrthoDB" id="2154311at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39607" checksum="91F64D02C219086D" modified="2015-05-27" version="1">MIYEEVEANPIEIKVEEAPFSQFDYDEVVSKPRFFTPPLQYQRNLFVRDIINSHMEGTGKKIRKLAVLGCGSLSLERFLMSSLGDMGIERVLSVDIDEHELAKGIKLLKIEHIPLADATRFARSVLLNIQPDLFIVSTPNHEYNEAFGLPNGHFRHGDHKFEFSRQEFRNWLFKIVGEFTPTYGYLVKFVGKVPGFDRLGGATQFGIIHKKRARLSGVVRHECSKVYRKVGETVVRNSLFSLEREKVKQAFRLWLQENKLLEENLIQSSIGNFWRVDMKEIVRNIELPTKLKNNLNKRSMVDMLRFICRGRVINEVYNGEFCLNIPHTVTKDELIEITSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA92</accession>
    <name>A0A0D8YA92_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA92"/>
    <dbReference type="STRING" id="29172.A0A0D8YA92"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="33549" checksum="4CF817A8DF2A75BB" modified="2015-05-27" version="1">MEDGVSSTNSLLVSLCEREHVLYAAERRPVKLPQGDGVIDWSCRDREATWICSAARRLHLSTDSSTLAVAILDRVIYSTRVPIKYVNCVAVACLSLAKKLCEDHEEDASLYLHKLRLSYSSRELKRMELRILDLLGWDAFLPSFDRFLVALLKPMCGQWLMSPLRSHIEAIVCDSSVMSQFSPSTLALSVVSLLIEATSKRWMQAIQVQIKLCKTDPSELLSCRKRLSNIWSYALMPSLTPFEWFLPSSELPTSAATTSCRGTTFVSTSAHNGQTDSTKVSVSAAVTEVVISSPNAPQPTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAD6</accession>
    <name>A0A0D8YAD6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aph-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAD6"/>
    <dbReference type="STRING" id="29172.A0A0D8YAD6"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="32306" checksum="1F2F6E28616462AC" modified="2015-05-27" version="1">MGVWLTVACYLITFSPSAALFCRFVAKDPLRIILFVLGAFFWLASLLICAFIWLAISMVWDALPLTVLFSIILQDAARILYFWLLKKAQRGLNKITRPGATSIAPGVTDLHNARHMLAMVCGLGMGVMAALVLTMNVFAEFSGPGTIGLPRAMKMNTRDIQSAGTQLPLYYALSGCLSCLFNVTWTIMVSYTELYPYFHSDIRLQLWDSCHKVKQGQFWALPGITATSVHVIVSVASWYNSYGYQPIVLCVQFTLLLGCILYSQVIMGATLNSVVEGEFLFQCKFVLNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAE1</accession>
    <name>A0A0D8YAE1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAE1"/>
    <dbReference type="STRING" id="29172.A0A0D8YAE1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000039">
        <property type="entry name" value="PhosphoLipid PhosPhatase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF174">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2_HALOPEROXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="34197" checksum="C761CB8FF06C9BAB" modified="2015-05-27" version="1">MKLKRITFSGRLYSSHNNNETFRRILIRGLICMVLDISIALAISILLFYTFSGYAISPYQQPLPCNDESIGKPFKPNTVQTKHLLLISLGTPFLVICFVEALVFHYSHGQNKVANYFLTSTFLYLKYLFTFASCIFLMEYLKCTVGRLRPHFLSVCQPDWSRMNCTGREYIPASETYCMNPDARRIRAARTSFPSGHAAAAFHVLFFLLIYLPRMARITGISYLYQTRNVFLIICTCWTTFTAVTRVTDFWHYSTDVLGGIILAAVCVLPVFGWQWRNYDDVYLPRQLTKSRLHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAS8</accession>
    <name>A0A0D8YAS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAS8"/>
    <dbReference type="STRING" id="29172.A0A0D8YAS8"/>
    <dbReference type="OrthoDB" id="5871344at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="258" mass="29392" checksum="FCFF83AE582705EF" modified="2015-05-27" version="1">MTDEIFVTHCSLCLLSELYKLITKIILLCISNKFDETQKIGNHHHDVSNIFDVIQEKNRLVVTLVEGISLVQIIYEHTEELTQMKNLISAIFVHMQLCFSDGDHGLGSSHSSQTFEPSTSKRVRHTTDISPVREYPEYRNETFSESHLLLMFHGMDAAMSITINLSSTFCTMTDPSFLLQSISAQIRRRRDYAGQKIADTSQEDIPSPNEIEDDVIVDLYPANAFRENELRGFTTFLLVNIVNENLLRITATELMSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAZ7</accession>
    <name>A0A0D8YAZ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAZ7"/>
    <dbReference type="OrthoDB" id="5829932at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336532" evidence="1">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="27512" checksum="FDB576E226BB5140" modified="2015-05-27" version="1">MTFQHLLILHLTFFTYSYEKLSSNINEFDPRITYDGKGMKFDMGSVESSSSSIPHIEIPIGDGINLRVPKAFYHYSEQNVEANSDWGIPDTGTMLDFSTLLKNNRKDINGIYLPLPNMQPINLHFISQRSFEKGIDSSAYDNASDSALADAKRICAHSSERDCERALLRYHRTKTQSVLKQNTPLHQQLLDLGDLTSYSAVRDHDNRDMGVMVGLQGYQPLYVNAAINKNEDKNIRIGFSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBP7</accession>
    <name>A0A0D8YBP7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBP7"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7341" checksum="6F7987D73A5E2581" modified="2015-05-27" version="1">MMSYIVYLFRFRIYQGLYRVSSLCVLGDLRDRSDIECDSHSGVVTTADETMCCKLRTDRCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBZ9</accession>
    <name>A0A0D8YBZ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PDZ/DHR/GLGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBZ9"/>
    <dbReference type="STRING" id="29172.A0A0D8YBZ9"/>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12036">
        <property type="entry name" value="SH3_MPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058845">
        <property type="entry name" value="Kringle_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035601">
        <property type="entry name" value="MPP5_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25866">
        <property type="entry name" value="Kringle_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="389"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1121" mass="128377" checksum="ACF7159E8772C132" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5W7</accession>
    <name>A0A0D8X5W7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719138">
        <property type="protein sequence ID" value="KJH39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5W7"/>
    <dbReference type="STRING" id="29172.A0A0D8X5W7"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18869" checksum="C2B9E3863C018380" modified="2015-05-27" version="1">MEIINELSRIRRISEFNETIISNLRGGYLLNNWLNNVLNVANGTMTKPNRMLLYSSHEGTLLSLMYAMGVANDRLVPFASSIIMEIFKDGSDHYVELLYRNDTTAPPYLLEIEGCQPCTVQKLLKRYGSMVVESYGQQQVVCCSTATRVICTAFSIIYLHLQFTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6P2</accession>
    <name>A0A0D8X6P2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717576">
        <property type="protein sequence ID" value="KJH40195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6P2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="68" mass="8163" checksum="C745E2C1CBE8AB5E" modified="2015-05-27" version="1">MVFGSYTFKLVIITRKMYVKRLHTMIMLSSTSTTSMHWTPMFWSTLYIKFAILLNNKSFLFSFISYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7W7</accession>
    <name>A0A0D8X7W7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_14224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN719555">
        <property type="protein sequence ID" value="KJH39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7W7"/>
    <dbReference type="STRING" id="29172.A0A0D8X7W7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="5005DAF70DEF3F7B" modified="2015-05-27" version="1">MAGAEFIRVTARIRPSNVGERIVTIQGAKTVVFNSCEPKHFKFDSVFDESITQEKLFEDIGGRIIDGCVEGYNGTIFAYGTIHSHILLYCYCTIALRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Z6</accession>
    <name>A0A0D8X7Z6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719289">
        <property type="protein sequence ID" value="KJH39912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7Z6"/>
    <dbReference type="STRING" id="29172.A0A0D8X7Z6"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7088" checksum="AA9ABAC3190977F8" modified="2015-05-27" version="1">MYLFEQCPSSTARELVFVQAIWRHGDRAPPSLPYPRGLYNETAWPRGWKQLTNVSQKYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X846</accession>
    <name>A0A0D8X846_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN717040">
        <property type="protein sequence ID" value="KJH40713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X846"/>
    <dbReference type="STRING" id="29172.A0A0D8X846"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="443" mass="50891" checksum="89472AED4C5C1FC5" modified="2015-05-27" version="1">MKSIMRTCSNKKMAAMKAMNASDSNDTEEEDSPSSGDNEETTRLQSQSVYQPLISQTSHKKNLPGALLAPPHVPRWYIKRILEEERPDLAEKNGKFNLELNEMYLLDKHLRERAELQIDDMIVVNDNRDDDDRDYVRYQIQLKYNEGRYSSIYIVSKQVCRGNNVSNNSDLYVLKTGNRNGSSTFTIKMKRELRILSIMTKARIPWAPRLFDSGTVCDMPFIVMNLLDMNIEKLREMIGGRFKLSSVFYIAGELLNALVELHNHGFVHRDVKPTNICVGVGPLSSRIFLIDYGDTVRIGKNISTPDSYTLPYWSLDCHRRSCATEMCDFEGWFYTIGDLLVPSILTWKSILSEKEVKVAKTVFWTDFPSRMTTAPPAFISIAETIHATNDQHKVDVERLKNQVKIGLDQCVKRMQKFTPEWVRPSVRQRAIATTRQTKSRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X948</accession>
    <name>A0A0D8X948_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN717435">
        <property type="protein sequence ID" value="KJH40267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X948"/>
    <dbReference type="OrthoDB" id="5868824at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16468" checksum="940C36E22155774A" modified="2015-05-27" version="1">MCHYWIEAQPGEKIEVILDSFSRGFQVEGCKYAGVEIKTGSDKRYTGYRFCSPSSSGTRLVSTYNVVPIITYNLRRPSTARLRYRSIRSDTEALESTSMPVTSTPSPSNDFVLFKQTFALQTTTTYRGKCPVEGRAIFANCHFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9F5</accession>
    <name>A0A0D8X9F5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_12816</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="KN716878">
        <property type="protein sequence ID" value="KJH41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9F5"/>
    <dbReference type="STRING" id="29172.A0A0D8X9F5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJH41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="213" mass="23556" checksum="17BC11C51B5B00B4" modified="2015-05-27" version="1">MSGAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIFLIGNKSDLDGQRDVPYEEAKAFAEENGLTFLECSAKTGDNVEDAFLETARKIYQNVKDGSIDLNAADTGVQPKQVLPRAAAATAGPGKKDCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9V6</accession>
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        <name evidence="1" type="ORF">DICVIV_13630</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KJH40414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0D8X9W0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="68" mass="8052" checksum="1CB350DB4798FD75" modified="2015-05-27" version="1">MVLIVVTDAEVFSKEKLIDWKKIRRKNRIYSDQYVDDYCIRVRRMDDVSWIFSDVINVKLVVLISASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA27</accession>
    <name>A0A0D8XA27_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13424</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717080">
        <property type="protein sequence ID" value="KJH40617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA27"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="238" mass="26592" checksum="A80A335447231C7C" modified="2015-05-27" version="1">MDKKNCRIVSREYKRPSERIPTRGVNVFEANVGKLYPQLKTISGLRNGPHHNNTLEEKKAIPTNSLQLMKFSIAICLTVVSVMDGCGQLPQGQDISTVPANVLRHSFGVDQNCIKNLRTLVMLVSKDKGHDFIAIRLANCGKKSLSRDAGELINLTAAAVDRIAAKHLKILPSVLMKYCLDFHTLSVRVRSFTWKTSRTVVLHEMETFTTLVIITQSTCRQLATNFSHESFQIGLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA75</accession>
    <name>A0A0D8XA75_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716813">
        <property type="protein sequence ID" value="KJH41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XA75"/>
    <dbReference type="OrthoDB" id="5791078at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19741" checksum="0C6B7E313CCB4F9B" modified="2015-05-27" version="1">MQNNNGKIKLVLIFISRRFFLKVGLDNAGKTTVLYKLKLGEVVSTIPTIGFNLETVEYRNVAFTVWDVGGQQRIRALWKYYFHDTHAIIFVVDSADTKRIEEARHEIHSLVGDTELRNTLLLIFANKQDMPNAMNAAEVTKNLHLSSIRDREVGSMHISWKASSFTVHRFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAD8</accession>
    <name>A0A0D8XAD8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717085">
        <property type="protein sequence ID" value="KJH40609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="10170" checksum="4BCF4794931A982E" modified="2015-05-27" version="1">MHISDRPTFIPNENAFSEKSSLKGKEKIKASISQTSQSKKARACSAWFVIFAQQTSSSRSAATQIFRPSAPLPPSSVTSVVFAATPNNGVVNQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAV2</accession>
    <name>A0A0D8XAV2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717023">
        <property type="protein sequence ID" value="KJH40764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="33623" checksum="F7D903C8BEB925EB" modified="2015-05-27" version="1">MDIGKWKIFSTILMIIGWLAALGASIVANFQEGAQLAIHNTGAFTLFFGIVIYFWGQLIIAYALKPKMVSTHLTNFRLILNILCTVILVFHVTCLFAKPFVKSTNGTKPVDAVPNNGIVRHMKGDPFYYNWIASTISEWTLAILLNLHLLTYVHDLNAVSVAIANSSKCGSLVKTVNDDMSVDQVYAECPTTIFNLTSSRRQLHRIDQLHESSSSLKLILSSDDFEIVSFKHFKLQMAIMFHLEHNHLQPSTLDLTTINISTFDRVRLFSVHVICGNRLQKECYRSDDLGYSDDRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB38</accession>
    <name>A0A0D8XB38_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716760">
        <property type="protein sequence ID" value="KJH41793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB38"/>
    <dbReference type="STRING" id="29172.A0A0D8XB38"/>
    <dbReference type="OrthoDB" id="6097796at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="166" mass="19379" checksum="F475A5854446712A" modified="2015-05-27" version="1">MITNFILSRYNKGLIPKRLQNESIKVSFSMELYQIIQVNEPQQYLMLNAWIVERWTDNLLGWDPIDFSNVTEIMIPYDHIWIPDTTLYNSLIMDDKNTRRLLNAKLTTRGFFPFDVQTCKLTFGSWTFDNTLIDYFPFNASQAIGTANCIDNEGWNVLKTSGISFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB93</accession>
    <name>A0A0D8XB93_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein orai</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Store-operated calcium channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716747">
        <property type="protein sequence ID" value="KJH41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB93"/>
    <dbReference type="STRING" id="29172.A0A0D8XB93"/>
    <dbReference type="OrthoDB" id="61124at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.140:FF:000003">
        <property type="entry name" value="Protein orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="31373" checksum="130F975D61E9BA96" modified="2015-05-27" version="1">MPRSLDPSRTALLKKSLIPRCSISVDDIQSLSSHKGDNDPTGFPWPVPQFFLQVPKLSNVSSTASLRPSSSLHASGAKITDIELDIGHRGELDMSEKYNYDLSKAQLKASSRTSALLAGFAMVALVELQYDQNTPHWLLILLGVVTTLLVSVHLLALMMSTCILPYMEATGCTQDSPHIRLKVYIDLSWLFSTCIGLLLFLAEIGIIFFVKFTSVDYILAGYITTAMLIPVVIVFVIFSYLIHKSRVSYTLGRFKDKVDTMKQFLDVEAQIPKSNPRNVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBV6</accession>
    <name>A0A0D8XBV6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN718977">
        <property type="protein sequence ID" value="KJH39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBV6"/>
    <dbReference type="STRING" id="29172.A0A0D8XBV6"/>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="192" mass="22670" checksum="E5C84670B53E6774" modified="2015-05-27" version="1">MSLNDTGGLNSQKSTCKYFHYYQLFRMSLGNSSRPLDYSFPKYFTTTSRMDKNQAGKYRSTVDRSHMLTYEMAQRPHHIGVRKAWLTWHSQNLEGFRQSQPLVVVQDEIIRRFIRGFFPQNVVISGEEIVIKRRGNIVVVAGFLQYSRRLDIRRIYWMFGFTEEFLSILLKQPVKLELAFVESEADLAYNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBW1</accession>
    <name>A0A0D8XBW1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716713">
        <property type="protein sequence ID" value="KJH42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBW1"/>
    <dbReference type="OrthoDB" id="5870807at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335654" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8855" checksum="583F115AA6ECFD38" modified="2015-05-27" version="1" fragment="single">MTRFYSMAIFNLPFLLFAIPATFKRVDIPDCGGTGMTIYLRGFMLDQHNYVRSTVAKGNFPKENGRHWPSAANMYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBY4</accession>
    <name>A0A0D8XBY4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718872">
        <property type="protein sequence ID" value="KJH39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBY4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9914" checksum="587D566CA8815E70" modified="2015-05-27" version="1">MYYRMIVQPEHLITSRKAILQREIKQAGPSAGERFSDRPREVIIDTFRRRTAIEMKARPTKLVAEVCKKKRDEDGTTVHETGVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCC8</accession>
    <name>A0A0D8XCC8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DAK1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN716854">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaK" evidence="3">
        <location>
            <begin position="10"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="351" mass="38041" checksum="37E3984B124CDAA3" modified="2015-05-27" version="1">MSTTKKFINEPSNAVDDALDGLVNATQCIIFDKNCRRVTLRSDYTEYCARGLVALIAGGGSGHEPFAAGDCYLNEHCLSEQHIDLFYLPRIDSWNLKILVISGSYVLYLGYIGSGMLTAAISGNVFASPPSRHISAALNSTTTRGGSILFVINYTGDRLNFGLAAERYTRAGHHVRIVSIADDVAIEASKLSIGPRGLAAAVLIIKIAGAMAESGKYTVEQIESMANQLSKDAGSMGVSLYPCSLPGFGQIFEIPKDMMEIGFGIHGEPGSRREPVATAQHTVDIIMTKLHSVISLTKGQRIALLINNLGGVSQLELNIIKSEAIKWCREFTNFFPSFVLNDVQVTKVRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCP6</accession>
    <name>A0A0D8XCP6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-13 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF9">
        <property type="entry name" value="BAI1-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="79"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="5">
        <location>
            <begin position="605"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="742" mass="85324" checksum="B6E34820435BE00E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD22</accession>
    <name>A0A0D8XD22_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="9997" checksum="B4A59ADF9B62A856" modified="2015-05-27" version="1">MSASGMVASPTRYSVYVGNIPYQTTEDAIGGHFSQAGRVTNVRIVYDRETGRPKGFGFCEFSDEAGAQNAVNTLNGTDFNGRSLRVNWANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDF1</accession>
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            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716761">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="309" mass="35570" checksum="F662BC27337D2716" modified="2015-05-27" version="1">MPMLNVSSSASQFFTLPFRRRKQRYTINPPDDSYSVIYLGNVLTVLANGEHCFDKPLALIWKAYCCRHGSDLTMELDITRSGLKAETKEQGLTEYWAHRITSSCAPNEHPKIFCWIYKHDGKRLKPELRCHAVLCKRSSDPLAIHTKLQEYLHSALQEYRREKLSVQNARLTGFAGCPRRKRMLHSGSLNFRPPVCRSKSAPRLGSIDEEQEIEENINNESVCYQAEPEILSSCSPANNAVKGDSYYVYYDDEYQKTLGSLEFDSISDESGYHEEKYLRGFSEDSYYSDGELVMLEEDYEESDKQMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="158" mass="18802" checksum="D41EB0CA1E7C3055" modified="2015-05-27" version="1">MMCHAHSRQRSLRHLNLSYVLAVTSDMPSDQSTKLLPQKLRRNERERKRVDQVNQGFNQLRLRVPRPHGSKHKLSKVETLREATRYIEQLHALLQQSNYTTSTNQQQRTHVQQQTYYHHSSADVSPYYPTHFKQDCSPTSSYYSDSSFEEQKYTQFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDQ2</accession>
    <name>A0A0D8XDQ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_13468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717105">
        <property type="protein sequence ID" value="KJH40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDQ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XDQ2"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
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    </dbReference>
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        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="32698" checksum="AB15959E62AEFBBA" modified="2015-05-27" version="1">MFREIWTTTPWTLPLNNAICFSSESQYVAVSFKDSLKAPITEVYLIAEPLVSSVTEITGRALAVISHFKGKSLLGKQYKSCWHPELALPMLAADHVSMFKGTGLVHTSFAHGFIDYNIAVSDNYKVESFVDENGCYTRHMGPSLENKEVLTAGQQEVLRNSFCSTSAQKPVAYLSSPYAKVSAIICYIANVLSMPALTYFGIFSDLLILKKDVVHKWKYRHSYPYDWRTNKPVIIRSSAQWFFDVSSMSKRAAQLARSIQIGNDESVAVVRRNRIASIEPIRLAIRTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEP0</accession>
    <name>A0A0D8XEP0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716980">
        <property type="protein sequence ID" value="KJH40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEP0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEP0"/>
    <dbReference type="OrthoDB" id="5799915at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8748" checksum="B98483194612146F" modified="2015-05-27" version="1">MMLFGSSGFAKSSPYSCRSLVVYNPHCHGFSSMTLSTSNLFANPTYDAVWKFWIRKIVTVFLPFTGMETSNFDLFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGN8</accession>
    <name>A0A0D8XGN8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716529">
        <property type="protein sequence ID" value="KJH43753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGN8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGN8"/>
    <dbReference type="OrthoDB" id="5870774at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="429" mass="48960" checksum="18BF3FBFE58E75D3" modified="2015-05-27" version="1">MHQNVVNHWPIHQIGVNAVRQLQLQVCENERLQVFYSNILEACQRKLTEDSLQCERNITNKQVSIIHLRDMGRIHDAVEMLFDSKMYISKVGAFILNRLSALSPHFCAYLVMEAQCLVVILNMLEQKITGRGPATAEILIILQEVFLRIVECQHLVVVAEVDAQLGDCAKASLHIFHAFYTYPAIVDGFGRAILALYRRRGAKKYFEKAPFYLNYATRSCITRGMELGKIYFVLSVESLNELRHGVVLAAAWHIYNVNDFDIQLYPGDSLLLKVANAVESLNELRHGVVLAAAWHIYNVNDFDIQSYPGDSLLLKVANAACSPISIYYVYIQSVNNPHDAAVRIQKAYRSFRFIRAIRSCFSRHAVVDAPSSDLHNMLQTNTFVVVPEVMSFYEVSKTVQRRHSEDLKWEQHEMQNIGKVISIAILIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGQ5</accession>
    <name>A0A0D8XGQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, carbon-nitrogen family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716609">
        <property type="protein sequence ID" value="KJH42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XGQ5"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="213" mass="23592" checksum="B3CE1B6A99A296A9" modified="2015-05-27" version="1" fragment="single">LAAKYGIVIVNPILERDEYKDDVIWNAAVVISQTGNVMGKSRKNHIPRVGDFNESTYYMESTLGHPVFETSFGRIGINICFGRHHPQNWMMFALNGAEIIFNPSATIGDLSEPLWGIEARNAAIANHCFTVAINRVGTEIFPNEFTSGDGLPAHHDFGHFYGSSYIAAPDGSRTPALSRTKDGVLIAEMDLNLCRQVKDAWGFRVSAEGYSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGV3</accession>
    <name>A0A0D8XGV3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10165</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BETATUBULIN"/>
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    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="47"/>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="449" mass="50095" checksum="EB39935C75D5C47C" modified="2015-05-27" version="1">MREIVHVQAGQCGNQIGSKFWEVISDEHGIKPDGTYNGESDLQLERINVYYNEAHGGKYVPRAVLVDLEPGTMDSVRSGPYGQLFRPDNYVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTNPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSAKGAQAYRALTVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDDQMMSVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATADDMGDLDAEGGEEVYPEEE</sequence>
</entry>
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    <accession>A0A0D8XHD4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_09974</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="15609" checksum="2E6AFE5B42AF07A7" modified="2015-05-27" version="1">MVGKDDDEKESDHDMYQENENATNISFCIKSEQSFENFSQLESAGIKEYSGTIMDKRHHQDMSVEKTFKETIEKKPDGYFVRLPWKDNAHKLPDNKGIAVQQMKSPIIKLAKDPALLTNYHQIITQQCKGVNGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM7</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="10881" checksum="4A8668CB3D724BD7" modified="2015-05-27" version="1">MHTVQPSRCRLYKYLPAIVHCAAQTHDNTECCRANGVAQIGEQCLQMCQPQVNPRRFWGVKSLRKDLVVCLAKWDQIMQCHQSGLRARKVTRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM8</accession>
    <name>A0A0D8XHM8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XHM8"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NR_DBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="retinoic acid receptor beta isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="257"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="507" mass="57466" checksum="1F7D710E2DC51740" modified="2015-05-27" version="1">MSFDGFSAARSPSSSRVSSSFYEFSSISDISSDYRPSQMSNSAQMICVKTEKPSPSQAWIPHSYSSYEASSLYSPSIANQLSDEGNAFPYRPYKQESSFFTEQVIFPTQSDFPVHTSFSDNGVNNNERSSPQPSGLLVPVGGKAILICKVCGDKASGYHYGVTSCEGCKGFFRRSIQKRMEYRCLRDGVCPIYKQNRNRCQACRFKKCITVGMSRDSVRFGRVPKRTVKEVSDGDTSDSDEKPEVSSTTSPEPLKVELNQLIQTVYEAHEEFSAMTIKRQRVITEHRLDFIIDDPPSLSNQLRAWELYTEKVTPDIHKTVEFAKRVPGFPSLHSGDQQALIKSSFFRIFLMRTYRGLSSRGLLLVDGTFMQLTFLHLIFGQFLNELLIFAHMMNGLNLNDEVVAVFAAVLLTTTESIYYHSKVEVDRIHDKLVSALRIKINDDFPDSVIFDLLMSKISHLQELAMHHDKIHNILRYNSTNVKISALYSEIYYLDDRSAPHNSRNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHY2</accession>
    <name>A0A0D8XHY2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_12076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716734">
        <property type="protein sequence ID" value="KJH41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XHY2"/>
    <dbReference type="OrthoDB" id="10250638at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="10">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="9">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="553" mass="61989" checksum="716F7A16CDD9CBE4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI96</accession>
    <name>A0A0D8XI96_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_11974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="KN716717">
        <property type="protein sequence ID" value="KJH42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI96"/>
    <dbReference type="STRING" id="29172.A0A0D8XI96"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000006">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="367"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH42056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="776" mass="87187" checksum="8490BC63FA052C97" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIJ9</accession>
    <name>A0A0D8XIJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBA/TS-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716704">
        <property type="protein sequence ID" value="KJH42141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIJ9"/>
    <dbReference type="STRING" id="29172.A0A0D8XIJ9"/>
    <dbReference type="MEROPS" id="A28.A02"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="42704" checksum="1321C8B6D36D7568" modified="2015-05-27" version="1">MFISLTNLNAEAGYDVPSDMKLSDLLALCSTELFGSEISPSKMSVFKYGERLKNISLTLQALGIQAGDVLLVKEQDVTPQLEQAMPTENSRLTELIKSIKMKNPAQRAHIYFKAKPLVDQYVRDPINFEAFLSVYERIIQDEIDKARLMADPASVEGQRLIHEQIQLENINYSYAQALEYTPEAYIPVHMLYIKMEINGHPVKAFVDSGAQVSIMSEACAQRCKLYHLIDKRFTGTARGVGGTQKFVGKIHSCQVKVEDHFFPCNFDVMADREMDVLLGLNILKRHQCNINLKDNVLEMGDGTRTSFLSEMEISTYLNNLAESDGTDYMVDDDLLSQAMSLGFSEDDARNALKMTRNDLESALQHLFIKADEKTLAKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIS6</accession>
    <name>A0A0D8XIS6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KN716536">
        <property type="protein sequence ID" value="KJH43669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIS6"/>
    <dbReference type="STRING" id="29172.A0A0D8XIS6"/>
    <dbReference type="ESTHER" id="dicvi-ACHE1">
        <property type="family name" value="ACHE"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="AChE-related_enzymes"/>
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        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF12">
        <property type="entry name" value="ACETYLCHOLINESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="538" mass="62293" checksum="44B93630D0BEE748" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ98</accession>
    <name>A0A0D8XJ98_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716457">
        <property type="protein sequence ID" value="KJH44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ98"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ98"/>
    <dbReference type="OrthoDB" id="10033734at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="19919" checksum="784AA8BC4ACD44ED" modified="2015-05-27" version="1">MTTCHKAYQNFYRITKIVTYGGDASNFESQLWGVQTAITALKRRLKTVAEPTPSMPSMIANDQPCIEMFEEKQLMAVQSMLRQDILREKRCIARFCWMLRSLEMNSKEEISSHSPRADQESEEVWRERSELEEAARAALLMEIVRLRNDCANLRAKIEYYGQRQESITTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJH8</accession>
    <name>A0A0D8XJH8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cysteine dioxygenase</fullName>
            <ecNumber evidence="4 12">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11516</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="4 12"/>
    <dbReference type="EMBL" id="KN716659">
        <property type="protein sequence ID" value="KJH42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJH8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJH8"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="UniPathway" id="UPA00012">
        <property type="reaction ID" value="UER00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000045">
        <property type="entry name" value="Cysteine dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="10">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23784" checksum="982C90591D7D797C" modified="2015-05-27" version="1">MNSLTELIASFHRIFAEDQVNVNEVIMLMESYKSNPAEWRQYAVFDEHKYTRNLVDIGNGKYNLMVLCWGPGMGSSIHDHSNAHCFVKILEGVLVETKYAWPEDSNFEAPLKRLDQNYFEENSVSYMSDKLGLHRMENPSHSDGAVSLHLYIPPYESCNAFDERTGTKTMCQVTFFTKYGKKVDYTGKKSGSLIDYGATVLNAHRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJT6</accession>
    <name>A0A0D8XJT6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716499">
        <property type="protein sequence ID" value="KJH44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJT6"/>
    <dbReference type="STRING" id="29172.A0A0D8XJT6"/>
    <dbReference type="OrthoDB" id="5871578at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="195" mass="22860" checksum="9586C50792BBE126" modified="2015-05-27" version="1">MAFKNLAKNYVVEVKSAHLPLHENTSKESVTYSSKKYLALEQECEKNEEFERSVTNLLTKTCRILRIIREDHPRQGKVCPFAAPRKYFQRKCYLFKQKYLALEQECEKNEEFERSVTNLLTKLATFFESYVKIITDKKQTISTSRNRTEELYNFLDDKQKAIAFLIIQMYSSAMKNPALSAKQYSTAAEVFFTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKU6</accession>
    <name>A0A0D8XKU6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716419">
        <property type="protein sequence ID" value="KJH45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKU6"/>
    <dbReference type="OrthoDB" id="5800039at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="8472" checksum="4AC81C3848F7E25C" modified="2015-05-27" version="1">MSVDQTISELSGTLAQLSTLVAHINRQITGITSRINHTLDNFDQAVANIAKDAGSVTYQVGDSVSQMSFFLTQNCLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL47</accession>
    <name>A0A0D8XL47_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_08737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716419">
        <property type="protein sequence ID" value="KJH45240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL47"/>
    <dbReference type="STRING" id="29172.A0A0D8XL47"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH45240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="328" mass="34901" checksum="0294878016970717" modified="2015-05-27" version="1">MVKEFSPRGGGGGGFRGSGGRGGDHKGGSFRGKGGGFRGGRGFGGDRGGNRSGGRGAFGGDRGSTRSPRGRGSPRLRGSPRGGRSGMRGGKAVIIEPHRYEGVFIVKGKEDALATKNMVVGESVYGEKRVSVDNGSGNSVEYRVWNPFRSKLAASMMAGLENVHVKPGTKLLYLGAASGTTVSHCSDIVGADGIVYAVEFSLRSGRDLLNVAKKRPNIVPIVEDARHPHKYRMLVGMVDTIFSDVAQPDQARIVALNAHNFLKNGGHAVISIKANCIDSTAEPEAVFAGEVNKLKEEKFKPREQVTLEPYERDHAVVVAEYRPKGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLD7</accession>
    <name>A0A0D8XLD7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AARP2CN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09392</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716462">
        <property type="protein sequence ID" value="KJH44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLD7"/>
    <dbReference type="STRING" id="29172.A0A0D8XLD7"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="77"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1066" mass="122289" checksum="B95BBEADE996541C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLL4</accession>
    <name>A0A0D8XLL4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reprolysin family zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716408">
        <property type="protein sequence ID" value="KJH45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLL4"/>
    <dbReference type="STRING" id="29172.A0A0D8XLL4"/>
    <dbReference type="OrthoDB" id="5842692at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF278">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="15495" checksum="1672B2F5F0B3168D" modified="2015-05-27" version="1">MCDAGPHVTSNAQDTLHQFCRWQKLYNDEDDESPNHHDVAILLTRGDICRSKSDRSSKVKFSDIAFSPNCLTLAPGKCDTLGLAELGTMCDPGKSCAIIEDNGLSAAFTIAHELGHIRLCVPKPSLPKSGMFIQQGILRNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM33</accession>
    <name>A0A0D8XM33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716448">
        <property type="protein sequence ID" value="KJH44797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM33"/>
    <dbReference type="STRING" id="29172.A0A0D8XM33"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23009" checksum="56FD7BB97826EEF2" modified="2015-05-27" version="1">MVKAVRGFTVIEELDLNKLPTSYFEPISEYEHRKFGCFSCFGGQIRLTLHMDRSAFVCGEGMTIVGDDVIVINLPIIIGSKPLMNTLCANSTASKDNNTSAVYRLCKHDRAISLLDSKERTLCNKAQLQHLNMYPFYSDLSTSSKQSKRLGVIATAIRAENKMMNTILSTVIEDRRDISMTDDCTAVTSCNTSDVIDSDRALMSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM53</accession>
    <name>A0A0D8XM53_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716556">
        <property type="protein sequence ID" value="KJH43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM53"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="30070" checksum="65107D340C2C2227" modified="2015-05-27" version="1">MEKLVVGDDVAQSSLDRKVVIEDDDYEVDELEESLLKVSLIDDEENQIITCTLKPIQRLKTVPSCNDELKKPVGDFHKYIEKSASSIAQESGHHGHFVTQHPSTKRVRDCIAASSPTTSSPLGKNSRVERPVNPSQSEFVIHDVCRSESDWNYFVQRSLLWEKVAVAVVKKKHNFTGEKLLQGICFCTPCGSPYYIPLDEDYFPGNEIEETVCPSSTPSQSISLSERIACTTSILQSCELYFVDALKDCRFLKSFKLEEIFSFFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMC2</accession>
    <name>A0A0D8XMC2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Unspecific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716440">
        <property type="protein sequence ID" value="KJH44897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMC2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMC2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF114">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22425" checksum="702C4B960D9513EE" modified="2015-05-27" version="1">MDRSSIRTSIGNALGLYHSLDAEPRDYTDAFLLRMKEDCKNGVKYSSFDNESLVVNIMDLWIAGQETTSTTILWGLIYLLRNPEVVNNVRKELLKVTGGSRSLSLSDKSETPYFLATIAFDPSRFLSEPSLLSSVIPFGIGRRACLGESLARAELYLIIGNLLLRYAIQSIDEKPSIDVINKFGIMKKPKPYKIKITKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMH1</accession>
    <name>A0A0D8XMH1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716545">
        <property type="protein sequence ID" value="KJH43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMH1"/>
    <dbReference type="STRING" id="29172.A0A0D8XMH1"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="337" mass="39355" checksum="A2AB537B83C14651" modified="2015-05-27" version="1">MDFDESEWKKKRDMMCLIESIHFRLNRFEARRRRHGEIILFYKNTRKLYLYGVSFFQRRKKRSAEDKSSGSSSDSGSEISEKTKTNVLPVYVAKKQKMPGTLLKPPRQPPWYSRRIIEEERPDLTGADGKLNLEREEAALMDMFIRGKSDLLPGDLIITDDNLDEDNRRFNRYEVQLKYNEGRYTALYLISRQICANNETVEKDTLFAMKTSIRPYSVNITLRMKRELRILNELKKAKCPFSPIVLDSGRVADLPFIVMNLLDRNIEKLREQCTAFRPSTAFFIAHECISALAFLHSLKYIHRDVKLTNLCIGAGPMCTRIFLIDYGDTVKKGKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNA0</accession>
    <name>A0A0D8XNA0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716418">
        <property type="protein sequence ID" value="KJH45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNA0"/>
    <dbReference type="OrthoDB" id="5856489at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="91" mass="9899" checksum="18148D250CF58EB1" modified="2015-05-27" version="1">MLRRPLTSIEIKADDIDHMEKVLLELYNKKSTAKTNIESDQTSNTTSEAVSCEDKQPSSPVSFTSSMDTSGNQTLSTILPSGSAFDPDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP18</accession>
    <name>A0A0D8XP18_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP18"/>
    <dbReference type="STRING" id="29172.A0A0D8XP18"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11659" checksum="D3A856546B8ADDB6" modified="2015-05-27" version="1">MYIVITELSGSIALNGFDIQVNNADYKHAGLYTCEAVNEYTAAGKTSKPLIVIERMLRVKSELAWIYPLSIIVVILILLAIIIGLCEVRKRRQNKLSEYMIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP33</accession>
    <name>A0A0D8XP33_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716401">
        <property type="protein sequence ID" value="KJH45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP33"/>
    <dbReference type="OrthoDB" id="5857164at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24900" checksum="91686CDD42CADF6B" modified="2015-05-27" version="1">MSVGVLFELGIESKTISHYVKGSAFDMVLVVVVRSFTSTTVAQHIMGLYNRIPEFRKLGCDVCVLTKGPPVGTRGGSYIKLIGVPFRRLYDENEALNELKFHRRSTIDLVGWEALLRTVDASLAEEPRPHSSSKITSNSPHEDQDYFITQKGGTILVDRSGNVLFKYIESEDVPWPTVDDVLDQVRKANESSPPKVSGAVKIDSEISAKEKKHDKQQTSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP43</accession>
    <name>A0A0D8XP43_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716400">
        <property type="protein sequence ID" value="KJH45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP43"/>
    <dbReference type="STRING" id="29172.A0A0D8XP43"/>
    <dbReference type="OrthoDB" id="5823958at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="5">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="485" mass="54401" checksum="AF1F8374F5A50DA6" modified="2015-05-27" version="1">MEVTEEICQNKDSCHYNCESEAMVFSTDSSHHESLYKLRGLSNEELRKRRRISEVQIRKQKQEEFFNNKRRLDNDEVEFTLADDCCIIPKAVLDMIKSGNFQNELAGLKFLRSKIAESTGDVNCMSRLGDISLISHLTRLLIRGDEDLTDDISWILVNMFRRHENRSFIGDARGQVLPTFCDLIHRAASSKNGAAVPMENSVLSQILWSTANLVECSVTSRNFVISCGLVQDILRIASKNKKLVILRHLMFLAAVLFLDIQESTPDLGELFPLLTLISRQLSSEDITIQSDAVRACKLMSECADFFQPMANNGIITKLVKLIPSCSSYITHGSLRSIANIVQETSLYTRDMVNNGLLFNLLPLMSCNTTMREACFVVSNIAAEGDDMLQAVLDAGTLKEIALLLEMADYETRKEAFYIMYHTAKSNRSCHLAALISADLLSVLCDFLTVLEHSLVADVMEALSALLAYGEQLNMGVTGELRLHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP65</accession>
    <name>A0A0D8XP65_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPG6</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
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        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
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        <text evidence="3 13">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2 13">Lipid-anchor</topology>
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    </comment>
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        <text evidence="4 13">Belongs to the phosphorylase b kinase regulatory chain family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44606.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="365" mass="41296" checksum="EB968A57C483D22F" modified="2015-05-27" version="1">MSVQSVIDAVSEAMKRHVHGNFMQNVYRARFSAITDKDIKLAMQNLVRPNRNESLSVDARQELDLRIGCSFTRFQTKFFQNKYGDLDSTVISYGPCQTPTLGFCVSRHDQILHFKPESYWVLQCVFETSDGISIQPSWKRERIFDRDVCQLFLERVKNAGIGIVIDRTTKESRKERPIALNTVELLRVASNAFGISPSSTMSIAENLYTQGFISYPRTETTSYSANFDLIGTLNQQTDSKWRDIVSKVLSHGIQKPRGGEDKGDHPPITPMKSDNGRLSGDMARIYDYIVQHFIATLMGPCVFDVTTITISCGEEKFVLTSKCMKDPGFTEVMPWLVIEDDLKLPPLSHGDHVDLKYGPFAVINE</sequence>
</entry>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">HannoverDv2000</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20711" checksum="BC281B625D6910C6" modified="2015-05-27" version="1">MLKRKQNLNYSVTAIQIQGFFNGVFDVGGQRSERKKWIHCFEDVNAIIFIAAISEYDQVLFEDETTNRMIESMRLFESICNSRWFINTSMILFLNKKDLFAEKIQRTNITVAFPDYKGAQTYEEATAFIEEKFEGLNANPEKTIYMHQTCATDTNQVQIILDSVIDMIIQANLQGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSB2</accession>
    <name>A0A0D8XSB2_DICVI</name>
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        </recommendedName>
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    </gene>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    <comment type="similarity">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="23118" checksum="A59CE586DA1319E9" modified="2015-05-27" version="1">MQLQDCVFRTRERSTWVATVDLDERIYVIEDTTISQFIRSSAKRNYGELRFRCRWVLRYHEIPNDAKTWRLDGSYIPMAKWHNTSQVAPVNHTTKSIIQPIQVESMGVHQVLRFLPGAHVHLVPPEQAVIRQDTNFISLQILGKNCFYRHYRIIEGWTNFLKEAETFGSFEYTEVASNKLQALNDSVTRKISQIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTV3</accession>
    <name>A0A0D8XTV3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="8">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
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    </evidence>
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    </evidence>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW63"/>
    <dbReference type="STRING" id="29172.A0A0D8XW63"/>
    <dbReference type="OrthoDB" id="5875562at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="673" mass="75092" checksum="75C52614EB267447" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWU9</accession>
    <name>A0A0D8XWU9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cohesin loading complex subunit SCC4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716273">
        <property type="protein sequence ID" value="KJH48277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWU9"/>
    <dbReference type="STRING" id="29172.A0A0D8XWU9"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="608" mass="68727" checksum="EF16E8EA74138336" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWZ2</accession>
    <name>A0A0D8XWZ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XWZ2"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
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        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="2">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="14842" checksum="90F938A4AF1C917B" modified="2015-05-27" version="1">MRDSMADLLPVDIPRDFTRNGNRNHIGHLCPVPSDLRFSYGTAGFRHNADLLTFVVFRMGYLAGLRARELNRSIGIMITASHNPAVDNGVKIVDPMGEMLSADWEKYASELVNTSDEQLPTAVRALEVQSGQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX40</accession>
    <name>A0A0D8XX40_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX40"/>
    <dbReference type="STRING" id="29172.A0A0D8XX40"/>
    <dbReference type="OrthoDB" id="5970620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019322">
        <property type="entry name" value="TIMM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21435:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10171">
        <property type="entry name" value="Tim29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13769" checksum="AA2841FE404F3948" modified="2015-05-27" version="1">MLDELCELRQVMTVLPLSIHNKESDAELAERSMLLCQDRLHYYNLWVFSLLVQSEYDHLVRIYESQDKNLKDWIWNEFFNNIYDVGFFGKWYRLGRKFKDYDINQDEIAHLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX46</accession>
    <name>A0A0D8XX46_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="9">HannoverDv2000</strain>
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            <dbReference type="Pfam" id="PF14748"/>
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    </evidence>
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    <sequence length="326" mass="34757" checksum="0E810840B3786E18" modified="2015-05-27" version="1">MTEFNRLCHVAGISDPMLLFVGGGNMASAIINGCISSGFTTSSEIAISCRSERTFEKWKSQGFSNVFTSTASMIKRFPRGVIILAVKPQSRHYVFASILSENSSLSSCPLLISILAGVSTDVLGKELSSIGFEGDLVRLMPNTAASIGNSATIYSVCDGVAVEKIEIVKHFASKMGICVEVDPRNFNAYAALAGSAPAWAYMFIESLADGGVLAGCSREIALKLAAQSVMVFPFLFSFTFIWYLQIILLNVNKLYISFIPGNNLIRNSKGAAEMVLSGNHPAILKDSVCSPGGTTISGIRKLEECGFRSAVIEAVKAASEKGDTIS</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48447.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="72" mass="8080" checksum="343976D82E6B41EB" modified="2015-05-27" version="1">MKFARNAESGGQNYDEAVAFIKLKFAELNLNPDKKTIYMHETCATDTNQVQLVISSVIDTIIQKNLQKAGMM</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJH48752.1"/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716252">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="64"/>
            <end position="85"/>
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    </evidence>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
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    <sequence length="83" mass="9368" checksum="980834BFFC299284" modified="2015-05-27" version="1">MILDEVNKSRQMMLKNSSTNANRNIREPLAAQCTDQRSLNLFTAVETQNYPTNFVPINSNFGNPLVAVFPRIAAEETERPISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44783" checksum="D2E3E77F1C67B758" modified="2015-05-27" version="1">MMVENKLLSEINSEAEPSWQSRSRSVVTSPVTLFVNSLLFELKKVTFKWKFGFLLLTKKSYGGLGNRNKMLRKNNSNKDSSTLVDLFTHLSSVFLCDEIDFPCETVLDCLRLHCYEKRMKLLDLDDMFLLNIANAMDGKTVMVFAQVCSKLRGLIMCNISSLKRTMSATFDIFISFNKQTKQEDVRALKCGRSIVEPSYYGYSLYDVVPPIPLCQLRITFGSNIEILKWTTEIRHLFKDCRIVPVALIFGGASSGVDLRCFNEDSFIAFVRLFVPHVKEVQLATSRLFEFSNSPRLVFSMINVLRLFGITYEQSFLRYTTEDIGRVIDLWRFSPRAHSCDVFINRSYGYDEINWLRYEAATTIDGNRVTNAIVQHALFENVKLHFHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="542" mass="61392" checksum="4703BD2F7541AD33" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZW7</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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    </reference>
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        <location>
            <begin position="80"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="36815" checksum="FCA18D58D146365E" modified="2015-05-27" version="1">MPHAHHYITPLDTVAIVRVIRSHSLLFAATTKALAQQNWSDLTNGITVLRRTLSKLEANAYDVLSTRFERVNVNGVSMKPSDSNTSIDSNSNNNSPTKKSAEDLLSMDEDDSEEKCDAIEQSFDNEIDKEFSMAISAVSTKLPPSQFFKKDEEFLAKVLCAVSPLEFYVIKVAHIRVLREIERLISYCSEKLCSQTLSDSLCWRENACLVRFEDNLARATIGHSGAYDLQVYLVDYGRSMFINRSECFAMPKFIAQYAPPLAHYCTLNDVDSRALDHATVKAFHEKILSVSEVTLKCEFLASVSQYGVDSCFGERRRTHGELVEIID</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716215">
        <property type="protein sequence ID" value="KJH50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y044"/>
    <dbReference type="STRING" id="29172.A0A0D8Y044"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="15551" checksum="3B69C8C33CB0EE5B" modified="2015-05-27" version="1">MFVPDEVYCCLGTLCIAGRLECVDKDRTAEWLARRQCGSGGLNGKCRPEKLPDVCYSWWVLASLAMLGRLQCVDKVDSMVRFIYACQDDESGGFADRPGDCPDPFHTLFGIAGLSLLGDTSLQPVDAVLCMPKYSLKGKSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0T5</accession>
    <name>A0A0D8Y0T5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0T5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0T5"/>
    <dbReference type="OrthoDB" id="5824098at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="505" mass="57648" checksum="8A3EB76DC4E9C675" modified="2015-05-27" version="1">MHEVDPGPQCSLISYVVPPGLSRIPAIGPSDPIHCAVSSLETISAKNSRNGNRNIKRGATHYSSSPSQTVTETVSTQKETPAILPSTQSFGEAVKPPIKSYHTAAPDSHSQQQRKSCLSKNITTAAPARQTLKKKTVAFGKTVNVSQTIEGTSRLEKLAKLRNTMSKTKTLPEEPSCNLENKENEPQDSGKKVEEQTLLDILKDVKSSLDALKIRDEERAEELRSIREVVNERGKEIDLLRGMFADYIGKECPTSFESKESLSPRGTKFEGGGVDRNIDIDKVGKMNVDQPLRRTNQRHHTSPTTYSMKEKCEAENSDGESITFEEFRRLLTKNPRLRRFVADIRAEENDRYITYDDRHRYENAASSRWRGSPRQPERFMEAKVEHVKRDDLNQRGSRGAHKYTEKVTVERSVRCSPTELTQYSVDTRRYLEDQILDDNYEAIESTYRPGESVSYYPERIRRNRNAEDSPDSNEDVRGGRTYRDYPNTTVEERRKQRRIRRADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0V3</accession>
    <name>A0A0D8Y0V3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716275">
        <property type="protein sequence ID" value="KJH48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0V3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0V3"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="21910" checksum="AD6E8649780811C7" modified="2015-05-27" version="1">MGIYVKQIVYNYKTSVVFQGEDADDWQNAPFIGCIQCPTGKPGPAGERGKPGIRGMRGARGTPGMPGNDGNPGQPGQMGPTGAPGEDGHPGKNGEKGQDYEQVVPRKGPRGPTGEGGEPGPEGDQGKDGAVGEPGPPGQEGTAGFQGAGGRPGDEGLPGKPGELGSDATYCPCPSRDQKKQEVDAPAPQRGSAPAPKFSAGTGGYSGGTGHAIDSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1Z7</accession>
    <name>A0A0D8Y1Z7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase inhibitor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716261">
        <property type="protein sequence ID" value="KJH48621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1Z7"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="24"/>
        </location>
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        <location>
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            <end position="101"/>
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        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="80"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20464" checksum="B9937810966A629D" modified="2015-05-27" version="1">MMTDMSNTNVDDRMSPGGKICVDDPTEYLKRQPKKSILKMKQEVSLDSKEGRAHFDEMNILATYHPTDKDYGTMKIDEPKTPYNFSDCESEGDDASGQAVRTRRVSLGKAVDPAEVAEGLHQGACSGSVKSFGSGTESDDDETHLTPEQIAHKREFEKKRKLHYNEGAALKAMKKQLEEEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3N0</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="65"/>
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    </feature>
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        <location>
            <begin position="183"/>
            <end position="253"/>
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    </feature>
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            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28292" checksum="568640E91618F5E7" modified="2015-05-27" version="1">MQLCWAYDKSQRPSFFDILGMFEKLRDKIEFQDDKPYPPYGGHYNGAFDVSQDSTSSERMELDRDVSSQRYYDMEDLSESRFEKSNSGSIAMRKQSAQATVRSQSPSEIDISSQFNRSGGQRVENSISTDTLTTVCDLSGQPPSFANSARSPFLLPSNDFYGNTSVKKSSLVLDHEKVVDMPHSRSWAGPSQRHRGAVQQPSQSSYAFAIRPSQSEVISDASSSQPSSLRNQTSTSISSSAYEKQQRNRVSQV</sequence>
</entry>
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    <name>A0A0D8Y3Q2_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Alanine--glyoxylate aminotransferase</fullName>
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        <lineage>
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            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y3Q2"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 12" id="KW-0032">Aminotransferase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <ligand>
            <name>substrate</name>
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        <location>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="410" mass="45330" checksum="C3C02419D2C269FB" modified="2015-05-27" version="1">MMCRFRVVSKYLIASKTPKMNTFARMSTYPPPARLLQPMVIPPRQLFGPGPSNMRDVVANTQSMSLLGHLHPEFINVMSEVREGLQYIFKTHNTYTFAVSGTGHAGMECAIVNLLEKDDVFLVVDIGIWGKRAADLGTRIGATVHTVTAPHGCAVENDVIKEALNKYKPSVLFVCHGESSTGVKQPLEGLAEVCSHYGTLLLVDTVASLGGAEFRMDEWGVDCVYSATQKVLNAPPGLAPISFSDKAIHKIKNRKVRVPTFYFDVMELGNYWGCDDQPIRYHHTAPISCVYALRSALAVIANEGIDESVCRHEDNAKFLYQKLQEVGLQCFVEHEKWRLPCLTTVKVPDGVDWKGVIEEMMKRGTEIAGGLGPTVGKLWRIGTFGCNSDKQKIEKVVTLLAETIAKKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3S5</accession>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5867269at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="189" mass="21930" checksum="99D9B44EDA2BEE79" modified="2015-05-27" version="1">MDCALRAYGAFVLWMHLVVYLLFKYIYRGNVDQFQIDKYSKELCRRRGKNSAMNPGKVNNMTKGATKQKDKAMTKKFPIMKKRKNEKKLNDTQKEETVNSGKRIEEESDYETSRHGSYALVLDKILRSHKRSIEEHIGLMEKNNTYTEEESQSHDDHKNDDNKNHNVASFKNQKLYGGSSTENTALIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3T3</accession>
    <name>A0A0D8Y3T3_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3T3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3T3"/>
    <dbReference type="OrthoDB" id="5825849at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
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        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="17932" checksum="57B5FC462A22182B" modified="2015-05-27" version="1">MFLSSPLFKETAQTGRKSLYPKVTVFSEILPLASKNSYKGKGLRPAASSCTQELQALFGCLRKWDFDDKPCQKQHSEYMDCVHESNRIAKYYKEAAKKGTLGDGDANGKSITTAQFNKLMELFPQPDLGQAPYRMMKRLPGQSYADDIFHRKHLKGKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3U2</accession>
    <name>A0A0D8Y3U2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3U2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3U2"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of primary metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336446" description="C3H1-type domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="148"/>
        </location>
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        <location>
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            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="33128" checksum="B2F10CC3E1851348" modified="2015-05-27" version="1">MTSLATLVLLLRSAQMSDNLPDVQTKLGQNDEVGKTAVAFMKTCLEDYSMYEMDDKQNSTCPPDLLGFDVSLLRNLTAQDAYLREQLNSCVKSALAAQDPCTLTDDEREELLRQKRKEDAYKTALCESYRRTQTCSYGKECRFAHGVDELRLPAQPRGRSHPKYKTVLCDKFSNTGYCKYGARCQFIHKITNPAILAQQMLARENALRTQTSHYINYDFHNSFDAHESGKRLVDMNISMPMEIINRRSDVDRALARTAGSQNVARIAKSIENRHTSLNSMHWFNSSLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Z5</accession>
    <name>A0A0D8Y3Z5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Z5"/>
    <dbReference type="OrthoDB" id="6372137at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28850" checksum="F59317F0F8739C43" modified="2015-05-27" version="1">MAYCLKFQRRDGCGKTKACLFKPLGCDPNLDCTIGLVFFVVGPNKLRVEMVATSLIPTVQQQYIAIGFSDDPLMGEDMVTECVMSDMGQFAGWEPEVFVSYNHGKANDRIFLNEEEHRTLFSNISSQVIDGRLVCHFTRQIIPKIDNKNGLVGSLDKDFYVMAATGSAQPDEVNAHDMNHGSHFYPIVSSARINPSQVGEIKYNHLLDTNMIQKQPATNAKPSSSTPTVSTSSNRSDSETENSSTSSISVAFAIIALLNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y497</accession>
    <name>A0A0D8Y497_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y497"/>
    <dbReference type="OrthoDB" id="10071877at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="76"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="612" mass="68258" checksum="2A52C59545E3EF57" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4B5</accession>
    <name>A0A0D8Y4B5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716181">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5875220at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="11097" checksum="6343C8274998F6A2" modified="2015-05-27" version="1">MKFTDSILTLVGDFAAMKRTPDYIPSNFPVEAQPMKSENNKSNNTRRHSLHISVGTEEIPKLGRNRSESVFSPSTLTDSKIYNKSDRRSSFSRKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5B9</accession>
    <name>A0A0D8Y5B9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF46">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
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        </location>
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        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="418" mass="47951" checksum="FBF8936248AE45CA" modified="2015-05-27" version="1">MPELRSQKYLPSFWHDDSAMQGYMSVIKARAVNPIDYDRKIRFWTNLISSSCEVEGNAIVSVDVLKRRFRRGDQLPSSIPVVCGVLMPLSKWQEQHSSWMGWSFQQLSKTSEWLFGTSKSISTERYIHLQTIKIQADELMKLYNKEFHSEVDGTGSIVEYSTFYDSAKDIVRTKENFDIVLAHLSDRGDVTIGQGRNGEQILKFRDSEEPVRFTEADASVHDIRRAMTKIEKDITVLERKAEKCEFYFKVVLDKTKAANLLRQKKHVQKDISDKDSQYQRLLTMLQQLAATKHNKEILDAYKAGTAAFRANLSRQGMTVEKIDEMMDDVANSIDEYREIEEAIGHAFVPKQNDDEDLEKELDELISKQKDSPAISNGTSNKVLPSLPEVPSNTLGYNDFEDEDALSLQKRLERLRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5E3</accession>
    <name>A0A0D8Y5E3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Wilson R.K."/>
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        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
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        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25177">
        <property type="entry name" value="Talin_VBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1694"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="1647"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1915" mass="208604" checksum="FA405C543C982D91" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y642</accession>
    <name>A0A0D8Y642_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_03772</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="19148" checksum="456EA9741C18490E" modified="2015-05-27" version="1">MQAKHELSDLTPEFLNAVRSIDYISPVTKINVAVRELPSFLCSPNFGKYPMPHHQATIHINCEHIDIIHEASRDFTNGKWSLRPIIEMTIPSSIDRSLVADDSSHVISLFTQYTPYRLTEGLWTSETKHRYVKHGQMDASLFVILKLILLLKRKEFRSSFQFMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Z4</accession>
    <name>A0A0D8Y6Z4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Z4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8712" checksum="4CC5F4D50ECC70A5" modified="2015-05-27" version="1">MVDVFAADINHLHSPMYTNFGLLNAPCVHHNVGGRPPPWMSDCARQKEVELCKTRTTEDIVYPSQRIGLMPANYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7I9</accession>
    <name>A0A0D8Y7I9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7I9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7I9"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046426">
        <property type="term" value="P:negative regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="46989" checksum="42E23E7A5D869285" modified="2015-05-27" version="1">MSTSLTEDYKRTQKGGNKAWEETYMKMHINSYKEVEGRGLTTKVAKDVVNMELDQCRIVLGSNTDDQDSYINASPVSIKRAHRNYILAQGPLENTCNDFWQMIWEQEVPAVIMLNKIIEGGRHKCAPYFPSKVGHALEFRDFSVKLEEEEKRHNFIVRRLSAKKTNEKDGQCKSVLSRSCLYLLNIVVFPASQRTILHVQYTEWPDFGVPASTKCFLDMLDFIKSQNVLSTSDEDPPCVVHCSAGIGRSGTFIIVDGVLRMIELGIPESEISLSDLVVDLRCQRFGLIQTPHQLMFSWHAIIDALQQPSAKSFLSDTSNDVVNVAVNESEERAIPIDRKAKRKTDEKLTDCVDDRLVKRREMVARMVARCRESEAARRGFLRNFPNQMGVSRGALFAASGLFLAVVVGYYVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y832</accession>
    <name>A0A0D8Y832_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y832"/>
    <dbReference type="OrthoDB" id="5770929at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10552" checksum="2C79663F3835E568" modified="2015-05-27" version="1">MPKLCSSCVEKRDFMEVDPPRTEKDFYKNYDPWMGVSTAILLALFFFVITVKSCVRYLIRKWRMHQFYKRASSGEENIVDNENCATDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8V2</accession>
    <name>A0A0D8Y8V2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_01391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8V2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8V2"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF44">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="71" mass="8474" checksum="E3EC98C783B2D328" modified="2015-05-27" version="1">MVRISVEILVSLKMFGGRPIECWLPAEYKSSWEDYTEMYCWARNTYFAPFDDVNLPQVHERGKTMKTYSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9A9</accession>
    <name>A0A0D8Y9A9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="11">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="11"/>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9A9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9A9"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="446" mass="50760" checksum="309DBFA052202033" modified="2015-05-27" version="1">MEFQLPKSRAIPFSAKNVKLISSPKEFYEFLVSRSKLATHRIVLGTLYLGSGPFEHNLVESISSNLRQNESLQVVVLLDYLRGTRGNEDGISSTTLLKPLADRASVYLYHTPKLRGFMKHILPKRFNEIIGLQHMKLYIFDDTVLISGANLSNSYFVNRQDRYVVFENCKELADFFHGVITAIGKCSFMLNIDGSIELNPCCYVHPFEGSFADYSTLMRSRINNVISSLTTEQLSSEPSSDTVLYPLLQMGLFGFYEEYEMLKKLLSSQANGLSITMASGYFNCIKEYEELMFTKGQYAMNIVTAAPKANGFFGAAGISGYIPSMYSSILQSFLRSKKRYNTTSVNMYEYHRDGWTFHAKGLWIETATQTATLIGSSNFGYRSVDRDLEAQVLLVTSNERLREQLREERAHLFDFTSILDEVTFKRGDHHIPAVVRILARFVRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA23</accession>
    <name>A0A0D8YA23_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA23"/>
    <dbReference type="STRING" id="29172.A0A0D8YA23"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF70">
        <property type="entry name" value="PROTEIN WNT-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8629" checksum="E4DEB5776C419F6B" modified="2015-05-27" version="1">MGLLNSTGKKGILGTSGRECKHSSYNSDSCDLLCCGRGYNTRLERRMIQCHCKFVWCCQFGSINEALPCNTSDFLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA47</accession>
    <name>A0A0D8YA47_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA47"/>
    <dbReference type="STRING" id="29172.A0A0D8YA47"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13311" checksum="AE0DB3585F5E4875" modified="2015-05-27" version="1">MLRKAFAYAVATGVAGASAAISSKLAFREFAVGYQYKVDAFWVIVFVLSNLLMWLMYTKSLSLVDSTMQCLAINTGTNYALTGVLGCAFFSESHCKLWCLGLSLVFFGVCLLAYDDKRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC20</accession>
    <name>A0A0D8YC20_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC20"/>
    <dbReference type="STRING" id="29172.A0A0D8YC20"/>
    <dbReference type="OrthoDB" id="93664at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF176">
        <property type="entry name" value="CORIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23896" checksum="3CFC679B3E6A979C" modified="2015-05-27" version="1">MNFYKKKPIHCNLAQCEQRFVRQYWFQDATFSQQLIVWQIFQEAVSQERIADTLQSRSAGGVLARDNEYPWVLLLTDSEWTRICTAVLVSRRHVLTAAHCVTSFSKDRNPEEYWCVSLFKIPITEVLVYPSFRCSNGTGDIALLELTLNMFTEASPISMPHLNELISMKVTSAGFGRNPDIPNTIRPMQVVNLTCRKTTKDKIITKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YGD9</accession>
    <name>A0A0D8YGD9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YGD9"/>
    <dbReference type="STRING" id="29172.A0A0D8YGD9"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="409"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="792" mass="92251" checksum="5B925805EE986C14" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5V5</accession>
    <name>A0A0D8X5V5_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">PAZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719578">
        <property type="protein sequence ID" value="KJH39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5V5"/>
    <dbReference type="STRING" id="29172.A0A0D8X5V5"/>
    <dbReference type="OrthoDB" id="10450697at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12752" checksum="0B79623386514CA6" modified="2015-05-27" version="1" fragment="single">FEAPDGKRYTVERYFAKRYNIKLKYPSLFTVSERHNPEAYYLVEVLFVAPSQRVLTQQQTQEDVAAVRKASTTLPKYRLKQTKVMKDALKMIPGNTDLEAAGISVDSDFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6R9</accession>
    <name>A0A0D8X6R9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717497">
        <property type="protein sequence ID" value="KJH40230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6R9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="210" mass="23140" checksum="E6B79952A157A937" modified="2015-05-27" version="1">MKPPLWKERQPTGVCLQACIWKERVSFYNGRRPDLLRGPKLRVTVAWPMKEQAAALCQTCLGALLWSAPVFPFMYILVSKPGIEGRTQGIFPQDPRMFQTVLGSLAVARSHIMLYLLLTVKTLLELDMIFLNAGDSGFIPGSGRFPGEGKGNPLHIMCDLATASEPRTVWNILGSCGKIPCVRPSIPGLETKMYMKGNTGADQSNAPKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7E0</accession>
    <name>A0A0D8X7E0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
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    </evidence>
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        <source>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="75" mass="8715" checksum="CBC809BB2524987B" modified="2015-05-27" version="1">MLVEQYRCRFGSELEASPLIRFGKRSPAFHLLSFENVEEKRDLIALMRYHLLDLGDQWTPRPSSGDLKSFSTTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="498" mass="57086" checksum="004DEB1E86A2A3C7" modified="2015-05-27" version="1">MLTNKRKSRCFFRSKEGRRVVKLTCSTAPEYEWRLVVQLRIKTGAANATILKVVDKDVFEFYPKSHPLSVEVTNNTIGIVKFELRVLNQLIEALPTFEEGDLAIHFSKGTPIHVYRDLIGLYSPYMKFEEFFLEKCTESAEKTYVEDFPKEAFVEMLYHIYPTLRPLYRNMRDIAKAAVAFQVVPIVYALSRHLWNFNGRSSCSRWCMGSFNQTGFEPESFFGAEIYRKLVCPAILAGKQNDYGVQFIARPYVQPDFFSQESALNKANVVLIFRRTPFYVNRGIIQAHGMSKFTVTSEGYLHALFTREMEEQCVKDVLVPGEVLVALLCSLYPLGPEVPLQFLRAAIVFCHDHDWIHMKNRLEQCLLQEPPDSCDAYRDQILFAEHFGLRNMITTCIQRAEASCNAFASELIAREDFNLISSETRDLIMDRLCSGWGLEPKHVNKLATREPTSFRERQIGLTSGGAKLNGDERNTATLAEMNSDHYFGSVRELCVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAC1</accession>
    <name>A0A0D8XAC1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipoprotein amino terminal region</fullName>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716800">
        <property type="protein sequence ID" value="KJH41555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XAC1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Vitellogenin C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
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        <property type="entry name" value="Vitellinogen, superhelical"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335612" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCI6</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <begin position="108"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="130" mass="14869" checksum="AF89809D085E5A6C" modified="2015-05-27" version="1">MYEPKAVVPRTAKLYTKHEYSEKFILILEGRALVTIGQAEMTFEAGPWHAFGMEMLEHLVARCDLDRRALGDVEHSRNSLTTDASKKFGFVPDYSVVVRDECTFLEISAHDWLVAYRSTLMSRGETRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="EMBL" id="KJH42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="45490" checksum="159D7406FE0624A4" modified="2015-05-27" version="1">MILHPGEILLVGTVCGVSLTIPPYIYFKAEIMKRLEELELQELRNGEIDHCTDNKGGPFVSKLMNLNGDDTKCLTSMMTLHATKDDFSQSSVVQFPTNSIEFPNTCKNQETPTSSTQVESFVATTKENLTENEVYDDDVRHDFSTDAFHGEELVEMLTNQEEDYDENVHAYKPPRGINVEDYQKLLRVIESINSEGSDSDRISEESNESYKEVEQMDEEGSELDSDDITDAEFQNKDYIPSPFVEKVKSNITVANVNDRIEVKGECDNLSAKVSQNEEKLKRNPMRKKKKAVVFAENLEDATLIDKNAPPCDVRASTACTSKTQPKKILTNCDEKSPVDEQAVMNVRSEKANCSYAFRDTSTAFTGVFQEKNLDYLASDCDQTIVTEPVKRQSLFKIKSRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDL3</accession>
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        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">DICVIV_12295</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716770">
        <property type="protein sequence ID" value="KJH41734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDL3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDL3"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF286">
        <property type="entry name" value="CUTICLE COLLAGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="66"/>
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        <location>
            <begin position="137"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="320" mass="32139" checksum="C4B2B22ECA64A775" modified="2015-05-27" version="1">MDLKETEEQRQMRRIAFVAVVVSTAAVIASVVTLPMLYNYVQSFQSHLMVETDYCKARSRDMWLEMTALQAGKGMIHRQKRAWLFGQWIPEGGSGGGASGGSGGAGRNTAGYGGYGAVVNAEPAPTCCTCNQGAAGPPGPEGPPGNNGRDGKNGKDGKNGRDAELLTAPPSEPCVICPIGPPGPMGAMGPKGPPGPKGSPGEPPKDGVPGEDGMPGQPGPVGRPGRDGMKGAPGSPGRLIPVPGPQGPPGKPGPPGPMGPKGNPGPDGQSYQGPPGPPGDPGNPGHEGRPGPNGPPGPPGDDGEKGDCLHCPPPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDU6</accession>
    <name>A0A0D8XDU6_DICVI</name>
    <protein>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
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    </reference>
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            <end position="508"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
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    </feature>
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            <end position="187"/>
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        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="609" mass="70766" checksum="74D2EF8B1E0C453A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE72</accession>
    <name>A0A0D8XE72_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
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    </protein>
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        <name evidence="7" type="ORF">DICVIV_11047</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716607">
        <property type="protein sequence ID" value="KJH42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE72"/>
    <dbReference type="STRING" id="29172.A0A0D8XE72"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="17328" checksum="4A597BA0D1E77B37" modified="2015-05-27" version="1">MTVNYMREAATARLGTFLKLLFRWRGSVWKTIWKELAIYLFFYFNLSVFYRFMLKGNSYGVIFELFVTHCRNLSRGAATVLSFALGFYVSQISDRDISERIRRRFPTYNHLVRMPFFHYSSRNYNLNSFIGGKILPSSSSISELLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEI1</accession>
    <name>A0A0D8XEI1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716603">
        <property type="protein sequence ID" value="KJH43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEI1"/>
    <dbReference type="STRING" id="29172.A0A0D8XEI1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="157"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="478" mass="53511" checksum="3E206C701FC35B73" modified="2015-05-27" version="1">MLTGHLPFQGHDRKDTMTQILKAKLTMPHFLSPEAQSLLRALFKRNAANRLGSGPEGSEDIKRHSFFASIDFNRLLNKEISPPFKPAVTTIDSTLYFDPEFTKRTPKDSPAVPPSATAHELFRGFSFVSPSVVDEKKDEKKIRTIPTAKTHPITNDYVLKEEIGTGTFSVVRRCIMKTTKREFAVKIIKKSVCDPSEEVDILLRHGHHPHIVKLFDVYEDESCVNLVLEYCRGGEMLDRILSKRTFTEREAAASMVNLASAICYLHTNQVAHRDLKPSNIMYASNSGESESLRIIDFGFAKQSRAENGMLMTPCYTAQFVAPEVLKRQGYDRSCDVWSLGVLLYAMLSGQTPFAMGPDDPADEILKRVGEGRVTMEGKPWMDISDSAKDLVRKLLDVDTSRRPTAKQILQHPWITHRNSLPANVIVNNVYSVESVKGALEQTYRALTTTSSVSLRPVNASALAKRRLTQLPKLGICSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEK1</accession>
    <name>A0A0D8XEK1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimeric intracellular cation channel type B-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_13184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716994">
        <property type="protein sequence ID" value="KJH40851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEK1"/>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH40851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32718" checksum="CECF7129445820CC" modified="2015-05-27" version="1">MWPERLQLDQDILMDAGTYLHRLKMFPYFDIAHYILIICEVRDDLGTSAGLFSRKHPLSCWLSSMLMCFADSFLANFLLGEPVIVPFKRHDDILLTTIVWYLIFYAPFDAPYKLAKTLPIQCVLAVMKEVKRAYRVTHGVSHAAKLYPNSYIVQVLVGTAKGAGSGIMKTAEQLVRGVWLPNHNEALRPSFATKACLLASMVFCLEKNSIYITAPHDLVYLLVVGFFVYFKLSALLLLVTDPFSPIENLFCAVFMGGIWDALSRALAAARERRAGGHTSENGTISSGEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEQ5</accession>
    <name>A0A0D8XEQ5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716972">
        <property type="protein sequence ID" value="KJH40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XEQ5"/>
    <dbReference type="OrthoDB" id="5834955at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056710">
        <property type="entry name" value="DUF7808"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493:SF4">
        <property type="entry name" value="PROTEIN CBG13422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34493">
        <property type="entry name" value="PROTEIN CBG13422-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25096">
        <property type="entry name" value="DUF7808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335722" description="DUF7808 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7808" evidence="2">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="18512" checksum="B52AF5B986F4819B" modified="2015-05-27" version="1">MLRSIFLIASAVAFVIAYHQYRDLKCSTPTNTIRGGPDRAECQLILKDEEHQPGRPVPKGLGCWKEDHEGEEREYCDLVCPNSHTVFISYIDQGHRACFNFVTYQIEKRAEEQYLWRSGKCLNSTVNYRIGCKFDEPFDTQFKSDNEILTRLRSRARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF65</accession>
    <name>A0A0D8XF65_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716678">
        <property type="protein sequence ID" value="KJH42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF65"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="71" mass="8032" checksum="D07D394E12D015A0" modified="2015-05-27" version="1">MNCNRENNHLPSGVSSFDYGIVAMRLTANGEVLSSYSLVCFLSCLYDIIGSKWTRPEEVQLEVSRINPRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFK9</accession>
    <name>A0A0D8XFK9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716557">
        <property type="protein sequence ID" value="KJH43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFK9"/>
    <dbReference type="STRING" id="29172.A0A0D8XFK9"/>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF4">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335613" evidence="2">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="418" mass="48522" checksum="8031196F768CB557" modified="2015-05-27" version="1">MSELLVALFLSSLLVQCLSQDDVATIELSVQNHDEVLNSSQVVFVAFCADWCPFSRRLKPIFEESARVFKRENPQASVVWAIVDSVRQAEIGDKYFVNKYPTMKIFVNGELIQKEYRSTRSVEALTSFVKYQLSTAINEFTNEEQLNEAIDRSKRNIVAWVRRGDEVYTNIKKIASLLREECNFWVSAEATSSALSQDRLYYIDPDNQQEQHFSGDFRDYNFLKQWVTDKCIPLVREVTFENVEELTEEGLPFLLYFRDPKKKDEDKIFTEQVIRELYDQRAAVNPLLADGLKFAHPLKHLGKTKEDLPVLAIDSFQHMYLFPDMSQLTVPGKLREFVMDLHSGKLHKDFHETLDQKLIDLAKFKEKHGITDEDLEDNRENDGQMPSARPEDTTPPPSVFKQLKPSEKRYSLLQKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFL9</accession>
    <name>A0A0D8XFL9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ShKT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716658">
        <property type="protein sequence ID" value="KJH42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFL9"/>
    <dbReference type="OrthoDB" id="5869788at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ShKT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="39" mass="4278" checksum="ABC6D7F1AD846ABF" modified="2015-05-27" version="1">MCSNPTWRSVLVDDCPKTCGLCDQTGRSNQSITTSKCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_11484</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5877812at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
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            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="283" mass="30969" checksum="32ACF524AD17AF20" modified="2015-05-27" version="1">MLKDCADNSGRRMKSPTVGAGIMKSPKKRRQRTTQQHEVPRQQATRYMSSLRDPRTTALSFPDEYQAPQCLGLQLHKTSQIQHFQPIHTSTPSIQPTGIIGRTAPAEDARQRNTLSPSREIKREMPPPDIALLSIDDEDEELPPPPPTLMHTSVHHLPSPSLSAIQLVPSEAQTVLPPPVPPPPPPPNLVSNTNSASATFAGAAKPSMDSEEEKKVDTRSNLLAEIQSGIKLKKVRLAEEAAADKAAAEANDVAAILKRRMEHVMGNDDEESQSSGDDDDWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG73</accession>
    <name>A0A0D8XG73_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716633">
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    </dbReference>
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    </dbReference>
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            <begin position="21"/>
            <end position="83"/>
        </location>
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            <begin position="105"/>
            <end position="125"/>
        </location>
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            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="205" mass="21958" checksum="2F4CF7FCF1988B6E" modified="2015-05-27" version="1">MQEEYGNRAAPEILRLYASAVKKSTKPSKDLTTSTKSTSTLRATKNLPSVGSARSRPSTTSAQLSQNTGIGIRSSKQTVNPRGVNMTSTSFSRTSHVHPMNDVKRTQQQTQSQTAPVKRAPAVSARISRGSVKPVLVPNIVRVTKHPTKENCNVSGGNLKARSSSNLTNDSTTIVRNTSGLRPPTAVTRISTGIPRLSRPNSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG87</accession>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="29172.A0A0D8XG87"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335755" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="18906" checksum="FD4AC6B25C007B70" modified="2015-05-27" version="1">MHHLNCLFVIPGVSSVSAASSFSQTSEAITPKNSIAAGSILSGVSAASVESSRTLTAAQAPSITDDSQSTQSTVSAPQLTSMASIGKYLPEGSTVNESIGHQFVIPPEFYKVSCKLDTTVRPLEVTKETEAIEAELRRIDSETAEQKAIRERNRWALMSDEERRVKPAKLHINIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGB9</accession>
    <name>A0A0D8XGB9_DICVI</name>
    <protein>
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            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716625">
        <property type="protein sequence ID" value="KJH42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGB9"/>
    <dbReference type="STRING" id="29172.A0A0D8XGB9"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        </location>
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        </source>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="390" mass="45112" checksum="CEC61D4B0E47DE3A" modified="2015-05-27" version="1">MGHNPGALDEIDLNTLRDPAGIFELIEVVGNGTYGQVYKGRHVKTSQLAAIKIMNINEDEEEEIKLEINMLKKYSYHRNIATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSVTDLVKSSKASSIKEDWIAYICREILRGLYHLHQNKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDENPEATYDSRSDLWSLGITSLEMAEGHPPLCDMHPMRALFLIPRNPPPRLKRTKKWTKKFESFIETVLVKDYQQRPYTDQLLRHPFIKDQPPERSIRIAIKDHIDRHRRINKKGLQVLFFYSRFFNWKNVRRANETEYEYSGSDDDEPNPGKQNQSHRDGRFSRCFGLFLFSFLAFLSMLKCSLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGT3</accession>
    <name>A0A0D8XGT3_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
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    </dbReference>
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        <location>
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            <end position="151"/>
        </location>
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            <end position="1333"/>
        </location>
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        <location>
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        </location>
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        </location>
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    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1333" mass="152138" checksum="06B468653FA683CF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGX2</accession>
    <name>A0A0D8XGX2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716789">
        <property type="protein sequence ID" value="KJH41611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="ELM2_dom"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="19329" checksum="331EE2518F93D7A0" modified="2015-05-27" version="1">MPLDRSSIPNMDALKEAVRDSDYEIQAHFGWQEFWQFDAEPIEPIAANSKFSDKISDCSNAKWYYLKQTVHSKDASCSDCYDFCLPDWAVVRKEKYEDESTLGVRRLDCFRLYVPEWKNFRVETDVSGGHWQYPLASESTKRDKNGNWVSWIPTANKINTRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLE5</accession>
    <name>A0A0D8XLE5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
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        <name evidence="8" type="ORF">DICVIV_08492</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
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    </reference>
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        <text evidence="6">Forms chloride channels.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="6">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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    <comment type="similarity">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF58">
        <property type="entry name" value="BESTROPHIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="467"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="492" mass="57135" checksum="BC471439E8DFA51C" modified="2015-05-27" version="1">MTVSYNLDVSSVSAFTFFKLLFRWRGSIYKSMITELIAWLCGYYAVFIVYRNVLSKEAQLQFERIAEYCDEKLQYIPLTFMLGFFVTIVVDRWRSIFQNMGWVENLALTVATFVRGDTKTVTLYRRSIVRYCILSQIMVFRDVSLRVRRRFPTMESLIVAGFLHENELRDLENIKIIYNKYWAPLNWATTLCMKAYKEGYIETFLAAYSIQSEIKNFRTNLALLCNFDWVPIPIAYPQVVFLAVRMYFLICMVSRQYIVNETAINKNVIDLYVPFMTILQFIFLVGWMKVAEALLNPLGEDDDDFECNFLIDKNIATGLCIVDDTYDVCPHLYPDRLADPYYYPVFPEENHRNRRDSALLGSAEGIEFETEADQLKLTGVDVEASRNRNNMKHPSDSSLARRMSAAFVGKINGILKKPYRSQSVQPTHIGSVFQLPFDYAPPHVRVKSYNGDEENTRSEEEMSDNQRIDISMSNITNPPDNKYKTSKTSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11747" checksum="934CB8F0E7776D83" modified="2015-05-27" version="1">MIPDRDLQFEFSRETMTTYSNHYGRQSIRALLGGVNRAERQRRWLTFDCFELSVKINTVLCCRCLHKNTVHKQFVNELTRRYESSGRSMKLLANRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XLX7_DICVI</name>
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            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="NEMP_fam"/>
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    </dbReference>
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            <end position="134"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="484" mass="56259" checksum="1296363DD3C67193" modified="2015-05-27" version="1">MLITLELDTTKWSVPAKTSRELDLYVHRGLIYSFKNAFADIVVVLNLTNEDTYDLYKADNCSVVQEEFRLDNRLFGLLKGVNVWRNHQLNLFNHTFVGISTTLPYTIHAEILQLNYIRLGVFVAGLLLFIFARNLVRNSIFFYTSGCSFGLLASILIVVFIIYRMAPKTLIRIPFIIGGWSLSLYFFHFVWKNLALIAVHYQKYVVVYFVVVLAVSFAICYIKGPPVDSRSHDIAQWTLQAIALVLIYSSVQVQEISFVVILALFLRNFARSWIWRLILRVGRLFAIIWWKFFPPKHRLLTKEEYEKEGREVTKRELERLREFCRSPEADVWKLTCRVRNPRRLAQFVSGNESHILTNEENSYDDDLESLNSDDGDDHVKRKFSFSDEGDEWEERIVGYRSRKISNGYVTSNKSHESLQKLSSHSPSPSRFSDSRLKFCSPMDSSLVHRCKKQQSTTRISSKRRSRQASDEFLSSDSESGIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM22</accession>
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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            <end position="80"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="8870" checksum="32E6E34A88AAE8EC" modified="2015-05-27" version="1">MPAGSSMVLNESGASHLGGSDSFVPRSESWNQDNWRPVPPLAELKNVEWNSEDSPSGVPAIQIDDDTTRAFHRPPDRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMF9</accession>
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        <name evidence="5" type="ORF">DICVIV_09013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716438">
        <property type="protein sequence ID" value="KJH44937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="147"/>
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            <begin position="55"/>
            <end position="147"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="204" mass="23552" checksum="880D97397D670170" modified="2015-05-27" version="1">MDRLCVEALRDYQRALFSIEPCNDVTQFNVSYRGIVPSRNFFASTSLFPMFDQPKPQHSYIGLIAMAILSSPEKKMVLSEVYEWIMIHYPYFRTRGSGWRNSIRHNLSLNDCFVKAGRAANGKGHYWAVHPACLRDFERGDFRRRRAQRKVRRYMGLSVPDGDSSDDSPNPSPAFVFPIEKIRLHASPSRKRDFSINSLLADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMW7</accession>
    <name>A0A0D8XMW7_DICVI</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716381">
        <property type="protein sequence ID" value="KJH45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="21883" checksum="13E8AFC67187730A" modified="2015-05-27" version="1">MRMGLLTTKPELSSIEVNSQKENSCGASDNEGSSQQHKVILYRNPLDSPGGSCSRASNHASPMRNLSSAHGGLYVSAPGKIILFGEHAVVYGRTAIAGSIDLRTYVSLFTSADGRIYLCLPDLNVEKTWLLKDLIKAADRLAGESCLDILAVKATVRFKLPSCVGLGSSGAYCVCIATALLQTTGLIPSPSIVVSIESRNLSVHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMZ2</accession>
    <name>A0A0D8XMZ2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMZ2"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SERINE AMINOPEPTIDASE S33 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="130" mass="14044" checksum="0F4387C59C98F8E3" modified="2015-05-27" version="1">MGLQGNRSDSDDMYGYSSGKPSEKNVYSDIRAVYDYVRKSRPNKKIVLLGYSIGTAPVADLAASQPEGLVGVVLVAPFTSGLRLVEAQPKKPNTSILDRFNTSAIRIGYVACDNTVFSSCIALPCSVFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNS5</accession>
    <name>A0A0D8XNS5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716407">
        <property type="protein sequence ID" value="KJH45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNS5"/>
    <dbReference type="STRING" id="29172.A0A0D8XNS5"/>
    <dbReference type="OrthoDB" id="5874701at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
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            </authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <location>
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            <end position="82"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="337" mass="38478" checksum="06F2CFDF94D9BE92" modified="2015-05-27" version="1">MNSQSVEVLCSICGDKATGRHYGAVSCDGCKGFFRRTVRKRHVYSCRFNYRCVVDKAQRNTCRRCRFDECMRSGMRKEAVQNERDRIRRNSVCSIRDDSILNVLLSSEAIVRQLRSSVITRTVDAHRQATTGDVTDSMNQQLIYMVEWAKNLHSFQRLPINTQAALLRNFSAQHLVMSAAFRSIHVNDAVYLTNETCLPRYSPNVPDINRVAAKIVDHLTTPMRRLQIRETEYVALKAIVLFDPMVKGVQDSFGDIDETRQKVLESFEKYVLQVSPVRDARRRFANLLLLLPPLLAISRDLVEDVQLAKLFGLASIDELMQELLLPPDGTTVVEKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS90</accession>
    <name>A0A0D8XS90_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716341">
        <property type="protein sequence ID" value="KJH46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS90"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22587" checksum="77465C34F62880B8" modified="2015-05-27" version="1">MVVSNLSKKRTMMKMYFVIAQASIRMKSLRNSLRERRITFESPVVVYLYVELINSNRTTLFDTCHLTTEELVEIVKNKRTSLHGFDLDGLSTLVVLSKHIYHTFLLSTIVSHDGDTKEVLVSSAMRGMKSDIKFGEKSRCLVHVDDRNFKYGNWSSSPSSKIFTCDIVETLCVSGFCTEGYLHPPGSIGRSPNHGILSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSF3</accession>
    <name>A0A0D8XSF3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716306">
        <property type="protein sequence ID" value="KJH47465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSF3"/>
    <dbReference type="STRING" id="29172.A0A0D8XSF3"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF328">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="314" mass="32284" checksum="902CA34D48CB3DD1" modified="2015-05-27" version="1">MSPRSVAVVATSLGCFALVTCLLSFPMIMNEISDIRAELDAEMESWKLETDVLWRDMNKNGRIRRQAYGTVLPQHKHIQVEDKGMQGVHPHHLTEPLHQLYSAEPTCNCNADNTCPPGPPGPKGAPGFDGPDGIPGIPGIDGKDAENAKAQTQQYAGCFTCPQGPPGPPGPPGKPGPRGMRGARGQAAMPGRDGQPGFPGTIGGIGAPGPAGEEGPQGEPGDDVEHQIGLPGVKGAPGPAGEPGDQGLQGDSGAPGQAGPPGERGPQGEKGDDGAPGLPGEPGEEGEPGKDAEYCPCPKRNGVQNAQASSYRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSH8</accession>
    <name>A0A0D8XSH8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716305">
        <property type="protein sequence ID" value="KJH47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSH8"/>
    <dbReference type="STRING" id="29172.A0A0D8XSH8"/>
    <dbReference type="OrthoDB" id="5877574at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="354" mass="40104" checksum="9FBF872656456244" modified="2015-05-27" version="1">MLTDEDNRDISISMLNETTPPDLLLIKAFNHLHGVVHHKDQGVESMFYNDDLTQSSNSDGLGADGTISPKKIATLKSDHAIVIKATVACEKEDYSTGTRDVNEKNMKGEMETAVGRASDTLISATFDVSVLGDASILEIDRPSPSERLSELSLSSAIKSASIDSKTSFSPIVDLLKKDYDRSPIVNKDRKYNLNDSDISFLMNENRVYDMALRDVTDPTEMIEQLNRNIIVLEGEKAEALEKLLSLSDEFEKYKTKFLMQDAELLDVNRKLTELTRSKENAEKTVADYEFIVEDLKKRHIKQKEDLHAKMLALEEAWNKRLDAAVSGFRYPSRIDHRQNDVLTPRHLMHRKTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT67</accession>
    <name>A0A0D8XT67_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT67"/>
    <dbReference type="STRING" id="29172.A0A0D8XT67"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="65"/>
            <end position="87"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10409" checksum="8CC73B1174DE844B" modified="2015-05-27" version="1">MHRDGLSKADALARITSQMSLKEKMNMASILIENNGSKDDLKHKVDVVVRELESKWTPQFIRSTTYLIIFICLWFAFKAILIVYYWIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
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        <property type="entry name" value="LGALDH-like"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <end position="45"/>
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            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="405" mass="45058" checksum="86B291ADD9970EF1" modified="2015-05-27" version="1">MQSHTFTRARGVPIRCINAPINRYTNHDQEPSTSQAPQRSVSLASNRFRHNDVTDSSLPPTYVVRFHDEAAARRMQYRRLGQTDMIVSKISFGSAPIGGMFGNVDDSITQIVETALRSGINLIDTAYWYGHSRSESILGKVLSKVPRKAYYISTKIHDTDFEPQKNIILYETLPALEMARQSGRIRYIGLTGYELRKLASVIDCSTIKIDAVLTYCHGSMNDNSLSNFTYLLKKKGIGILNGSPLSMGLLTERGPPPWHPAADFIKETCLAAAHYCMSKNISISKLALAYAFEIEGTASCVVGMDSIQQVRDNIALAIADSPLTDVEQRVLDRIMRRYFDRLENAGWSGIDVGAYWKRLKKLGLTALATHRHSSVESLASTLNGLSLHSSPSSSELRTPRRSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTN2</accession>
    <name>A0A0D8XTN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal ion transporter, metal ion transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XTN2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
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        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="514"/>
        </location>
    </feature>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="565" mass="63290" checksum="A821947067050BA1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU18</accession>
    <name>A0A0D8XU18_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716283">
        <property type="protein sequence ID" value="KJH48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU18"/>
    <dbReference type="OrthoDB" id="5826894at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </evidence>
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    </evidence>
    <sequence length="108" mass="12023" checksum="E3B492106BF69550" modified="2015-05-27" version="1">MGDACSMMAADHFVVHFEKMNSFNLVDPNDLLNSVLSSTEGEFLVKGGEDEFGSIEPFLRITHTCNVKKPGCKRVSEYEIPKSKINGVYDMTFVTLDIHSAVDSEKCK</sequence>
</entry>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="624" mass="71174" checksum="0B5EB7149CAB0487" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="85" mass="9425" checksum="F198511F494F8E0D" modified="2015-05-27" version="1">MVSRLTLITFIVVALASFVAAQWGPYGDYGYGGYGGYGGYGGFRPYYRRPYWRRPFFRGPFGGPYGGYGGYGGYGPYGGYRPYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716298">
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            <begin position="15"/>
            <end position="36"/>
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        <location>
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            <end position="137"/>
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        <location>
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            <end position="77"/>
        </location>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47642.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="195" mass="22221" checksum="A826DCD132D086FE" modified="2015-05-27" version="1">MVEYSHTMNLEDMDIPTLLSILVGVLIVMSSSFIYLTRKQKNQVARGSEEFGTKEVGSGDIRKSGREKKSRQGKNDHWKTKVKDVSYDHVWSVTTLKGHTSKVTGIDFAQDGKKFVSVSSDRCVFLWDVRDFEEKEHKCISHVLDFDTATKVSFSPDSRSMVFAMKRLNKKPPFKCTEIVMEFLKLLGFQAVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV53</accession>
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        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH48395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="294" mass="33789" checksum="C3D2460F0897A024" modified="2015-05-27" version="1">MENCHLGRHQRKKAIPVMNKFRLGGPQQEFFTVAEDFADDVLRRTRHVLPHVARLCLVSTFLEDGIRMWFQWDDQQQFMQESWSCGWFLATCFVIYNFFGQFVPVMMIMLRKKVMIACGILGSIVVLQTVAYHILWDLKFLARNVAVGGGLVLLMAETQEEKASLFAGVPTMGDSNKPKSYMLLTGRILLIFMLTSLLHFKMSLLQVIEIVVGFALIILVCVGYKTKLSAMLLVVWLFGLNLWLNAWWTVPAERFYRDFMKYDFFQTLSVIGGLLLVIAYGPGGVSVDDYKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG5</accession>
    <name>A0A0D8XVG5_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVG5"/>
    <dbReference type="OrthoDB" id="5874484at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11410" checksum="C5DB6B054E23DAE0" modified="2015-05-27" version="1">MGGKMCDPFDLGKNKLIGEVLIGTCNVTLTVVPKKTTNKSISKQEEYSKYKNLTSIDINTQPVQVKRHYDDVQFGRSDLNKKASYDYIRFGKRNENAMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVG9</accession>
    <name>A0A0D8XVG9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein Srb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein srb family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716265">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XVG9"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002184">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS BETA-1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS BETA-16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00699">
        <property type="entry name" value="TMPROTEINSRB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="301" mass="34725" checksum="D6E14250233B3517" modified="2015-05-27" version="1">MNESEIDMECRKSTLHRNIKINFFMYFSLALMHSVAYPIAQIQAVISSLVNKPCDFFPPLYIYAPLHLCIFASNFGLMVSLVAICIERCVATIRSSKYERSNNVLGVMLLAFTIVGTVLVLRYVYHVDDFNVRVWSIVVLPPGSIEEGRKIVIVYVIVSMICVITFFVSSRINRRRCIVGTATLTTRYQTRENVITTEFAYHITGLQVLFFTSYAFMSSLARSIGDNLFQMDLKVHIIVRHAIYVVPIFMLVLPIYSMRRLKYYQRIRDDNIRSIVRMECRGVAGTQNYETIITKTWQLNS</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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    </reference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="228" mass="26176" checksum="3AE5A1CB6897C4A8" modified="2015-05-27" version="1">MNAIQISVCQKHDMLPYNVVCTNRHLQTLIKTFRNSSANRCGRSDYFTIVNFPTNSSIFDTCPLTLHNYLDAEILQFYHPNYNPKANCSLYEPLTKLVDGRVIVDRRARGYDCSARCLISYKDVSYIAETDKQIINKPDVYLLIIDSVSSYMSKRDKQIINKPDVYLLIIDSVSSYMSKRSLPKTLEYLKNMGGIQMEFLNKVGEGSRSNGFPLLFGKLKLIKQLMKI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </reference>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KJH46606.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="374" mass="42703" checksum="D76ACF1AC5A9CA71" modified="2015-05-27" version="1">MNVLPLPKRSKIFGMRYLAMIQSYNQEFCHVDINRFVTSASTPETLELIYLLTDVECEISGSLWDKAANLLFTTCPHNPKLQAFVTNQLIVVIQARSPCSLARFKFVLDKLNCAQPDADFLFMFCNEFLSRLRGYFSHIASQLIPLWIFSVLAYSTSREMETKRFTSLIWNHISQMLGSIASTISMELSLGNLEFNVVKFFMVLGSSKSSADIIRKIVADSVPLYMVNQIVILLKNDDDDLQERILRVCGEILTHVGHTLLAIAETEAHRIGLNRTSFVVLIQALVAKLLRSSMDLRFYAHVVPIYVSALIKLPYRMFIYSRIKDILIKFVEEPTIMSRISDNLADLNDVGCYNQLVKETDPRIRRFFDVQGST</sequence>
</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <location>
            <begin position="35"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16080" checksum="E9ECA70B3D7D8EAA" modified="2015-05-27" version="1">MNMSLGIRFITTPTRIRLNLIIMLLFSYCRTQLADDFNVEAKYSRRRLKESWLESSGHTYDTDDEDYINGGGSGSGIPVEEEMEGNDIYTVTTKSLMHVFHMVLNKRITTKISILSTFVPYTGSYKQYLTDYRDALHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX51</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
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        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF39">
        <property type="entry name" value="P53-INDUCED DEATH DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="28699" checksum="1A46B12A35D1B973" modified="2015-05-27" version="1">MRKEQMLLSTGSIEHGRMMGTAIMDSTFLAVFLTIAVSQTINMEHNRINKIPIGIFSRAAGLTKLNLKENELLSLPLDMGSWTSITELNLSTNQLKVLPEDVEKLINLEILVLSNNQLKRLPAQIGNLKKLRELDLEENDLETIPSEIGFLLQLTKLWVQSNKLVSLPRTIGNLASLQDLRIGENSLSSVPEEIGHLDCLKSLYLNDNPSLHNLPFELALCSSLEIMSIENCPLSQIPPEITAGGPSLVIQVTNINNAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXB1</accession>
    <name>A0A0D8XXB1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716244">
        <property type="protein sequence ID" value="KJH49145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXB1"/>
    <dbReference type="STRING" id="29172.A0A0D8XXB1"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12990" checksum="356832DACB4C6950" modified="2015-05-27" version="1">MEMMEWWLPERDLVTKFFQVIVPRFINREAPFTSIYRLPTQRLLQSKKGMVEMWRRYDIAILEIDGNPFPPVLGDEPKISSSLLNILLKESLNNRLRKLRTDLEKSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXI1</accession>
    <name>A0A0D8XXI1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716264">
        <property type="protein sequence ID" value="KJH48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXI1"/>
    <dbReference type="STRING" id="29172.A0A0D8XXI1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336011" evidence="3">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="607" mass="65282" checksum="8D991381995C1EFB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY23</accession>
    <name>A0A0D8XY23_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin motor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716258">
        <property type="protein sequence ID" value="KJH48707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY23"/>
    <dbReference type="STRING" id="29172.A0A0D8XY23"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="27155" checksum="6D93779F58D3EB93" modified="2015-05-27" version="1">MLGPSHINNSILDSYHCGLIPRACEALFAKLCSKAAEKGEHFTYEVSCRFVELYNEEFYDLLSGSQQKLLIRSDSKGVQLLGVSEHRVQSSLDMIRILEIGWESRRTAETAMNRESSRSHAIFIVDVKTEELINTIVNKKCATLNLVDLAGSERQTLTRTIGDRFKEAVNINLSLTVLGRVIRTLSDANRRCEHVPYRDSKLTHILRDSLGGNSRTVVIVNIHPDKEYVALYCLLFSIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYJ2</accession>
    <name>A0A0D8XYJ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYJ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XYJ2"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="646" mass="73803" checksum="D5D0D35D8C34D750" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYM6</accession>
    <name>A0A0D8XYM6_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_04262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000116">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
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        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="116"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH49595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="339" mass="38334" checksum="5DCF2798493959E5" modified="2015-05-27" version="1" fragment="single">MAIAASVVSATGLSIHLMNNADGTMLVSHSVLLLATNIVGLFVFYPLELVQRKTFRETRKCVETRMMLVRELDKQEKILLSVLPKHIAYEVKDDMEGKEKDQMFHKIYIRKHENISILFADICGFTNLASEYTAEELVLMLNELFARFDALAAQHNCMRIKAEIPHSKVCVEILRRYFANMMLICSSCDDMVCLQILGDCYYCVSGLPDVNHHHAACTVEMGLDMIETIKLVREMTRVNVNMRVGIHSGRAHCGVLGLKKWQFDVWSDDVTLANHMESGGLPGRVHITKATLNALNGEYIVEDGHGDERSKYLAEHHVDTFLVVEPKNKQTSQRPAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZG3</accession>
    <name>A0A0D8XZG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
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        <location>
            <begin position="1169"/>
            <end position="1244"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49159.1"/>
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    <sequence length="1262" mass="145903" checksum="E8AEB63AB87F68D9" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8Y083</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the MAM33 family.</text>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="237" mass="26616" checksum="EDCE019070328CCE" modified="2015-05-27" version="1">MRAVSVLRSIPRVMCVSRTAVTGHFYTRSVSTTHRVYNIAPELTQALAREIQAEQQLSQENLGGSAAPSFQGFNISTKGAEVRLTKQFSNESILVVFNVNHSVDMGDDYEEDVQSEVTQVPVALPPFTVEITKGDERLCFHLELVESVDVQGEYDFRVEEFYVAPAVKDDNEDVAADIYASSGKYIDPDLHDLLFVRYLEERGFDGQFCKTLVAFATHHEHSQYVGLLNRIKAFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1B8</accession>
    <name>A0A0D8Y1B8_DICVI</name>
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        <submittedName>
            <fullName evidence="7">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1B8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1B8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF493">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2M6</accession>
    <name>A0A0D8Y2M6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative H/ACA ribonucleoprotein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716210">
        <property type="protein sequence ID" value="KJH50264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2M6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2M6"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="281"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="49520" checksum="1934E908A14F02F5" modified="2015-05-27" version="1">MGKKDKQQVDVGEVQHQGTFHLKPSSAEPSLNSEEWPLLLKNFDKMNVRTNHYTPLPEGCSPLKRDIRSYISSGYFNLDKPANPSSHEVVAWIKRILRVGKTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYVCIFKLHNPVESEKKIKQALEKLTGALFQRPPLISAVKRQLRVRTIYENKLIEYDKEQQMGIFWVKCESGTYVRTICVHLGLLLGVGGQMQELRRNRSGITDEHDGLVTLHDILDAQYVLDHHKDETYMRRIVRPLEALLVEHKRIIVKDSSVNAICYGAKILLPGVLRYDDGIELGQEIVIVSTKGEAICIALAQMTTSTMASTDHGVVAKSKRVIMERDVYDRKWGLGPVASKKKQMIKDGLLDKYGKPNSKTPENWKVVDYSVRKADTAVEEDVSENIGSPKAKKKKELKELSTSSSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y308</accession>
    <name>A0A0D8Y308_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y308"/>
    <dbReference type="STRING" id="29172.A0A0D8Y308"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="401" mass="42860" checksum="2C0266E1575FE9C4" modified="2015-05-27" version="1">MYRVVITGMGAITPYGSGVQLLQKMLLEGRSALQFSDQLGFVVGTIPESSVDFNQWSSGDKREMSKASLLTLVAAEEVMSMSNAKSVEHSDTLVNIGTGVADLLEIGKTSTLVQNGQSRKVSPYFVPRILTNLPAGYVAMKYHMMGGAESASTACATGLHCIGNAFRAVRYGWARRAIAGATESCVNPIALAGFERMRALSRGKDPTCSRPFDKERNGFVLSEGVGLILLERLEDATKRAAPILAEVLGYGISSDCYHISRPDPTGIGAKLSMQRAIYDANISTNDISYVNAHATSTPTGDAVEALAIRELFGKRRIAVSSIKGHIGHLLAAAGAVETIATVEAIRDAKLPANLNLNESDDETDVALLRQVTEWPRPRIAVVNSFGFGGTNASLVISEYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y353</accession>
    <name>A0A0D8Y353_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716248">
        <property type="protein sequence ID" value="KJH49006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y353"/>
    <dbReference type="STRING" id="29172.A0A0D8Y353"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="12">
        <location>
            <begin position="540"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH49006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="835" mass="95649" checksum="6AE2B16919A69A4B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y407</accession>
    <name>A0A0D8Y407_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y407"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="34520" checksum="CA5E41CD1B362C55" modified="2015-05-27" version="1">MHNYPLRLVMGNEFTQYNLQSFKFVFRRHCIVSFILETTEWVLFMDADIGVVNPTRLIEEYMDTKYDITFYDRFCNWEVAIGSYIVRSSPFSRKFLLNFANFESQLPQSFHGTENGAFHAYILETIAPYESRNDAEVCYSIWEQSQNYDDLYLYEACIRLVLGSKRIFDKVQILRKGTAWVRDIWITGSQWSFDRDFMLHGMKESDRSMIPDGFFSKLRYIFKPRFTWYPPLTNDLDMTHCSTGDVKWQYDMRFQIPQSAIEKRLYVLSRQIERKRWRLLGQMKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4A0</accession>
    <name>A0A0D8Y4A0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_04479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 6"/>
    <dbReference type="EMBL" id="KN716236">
        <property type="protein sequence ID" value="KJH49396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4A0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4A0"/>
    <dbReference type="OrthoDB" id="5804929at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="255" mass="28283" checksum="DA77DB2FE75AA33F" modified="2015-05-27" version="1">MACAYSIMQQVSFPTKSLSGILLLKHHIACNLAKILIQNIATELCLVDVVANKVKGEMMDLQHGVIFTGRCDVKADTDYSVTAGSKMCVITAGARQKEGESRLSLVQRNVEIFKGIITKLVQYSPDTIFLVVSNPVDVLTYVTWKISGFPRERVFGSGTNLDSARFRFLLSEKLGIAPSSCHGWIIGEHGDSSVTYRFRFLLSEKLGIAPSSCHGWIIGEHGDSSGNFNDPSFLNKNRTSDLLLIHYVIIYHDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4M8</accession>
    <name>A0A0D8Y4M8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4M8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4M8"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="596" mass="66141" checksum="74CF713DA6D7C4B2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y541</accession>
    <name>A0A0D8Y541_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, Sir2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH51988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y541"/>
    <dbReference type="STRING" id="29172.A0A0D8Y541"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="31392" checksum="4B65CEC219AEADF0" modified="2015-05-27" version="1">MYRFVPAYKIPDSDMVKKFIDKVAAIDRLLVLTGAGIPDYRSEKTGLFARSNHRPITIQEFMACESARKRYWCRNFLAWPTFSRAICNKAHLAIASWERSEKFVWLITQNIDALHTKAGSTLLSELHGCGHRVKCMECGDVTGRAEHQSRLQKLNAEWSKINLPGEIAPDGDVEIEEGVHESFVLPSCSKCGGILKTDVVFFGDNVAQDMVDLCYEKIDECSGVLVLGSSLTVNSGFRFPYCASLQGKPVLIVNIGPTRADNFAEMRISAPVTEIITKLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6K6</accession>
    <name>A0A0D8Y6K6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_01344</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc-1, and probably the ufm-1-ligase E3 enzyme ufl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with odr-8; leading to deufmylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6K6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6K6"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH52498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="13921" checksum="6DB5A12AFE773632" modified="2015-05-27" version="1">MSENTSVSNSTSKVTFKITLTSDPKLPFKVLSVPDSTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPSQSAGNIFLKHGSELRLIPRDRVGSWGFVPFVIYLGFRKGPEPLPNGQVVPLTLFSLLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Q6</accession>
    <name>A0A0D8Y6Q6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Q6"/>
    <dbReference type="OrthoDB" id="5792278at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21990" checksum="F0C24408039A663C" modified="2015-05-27" version="1">MVMAISLITVGTLDSNDEKQCGAILVISTSVLLVQVVLLFCEVMDWMLAVFLPVYFHSSSPFYRLLPFIIGCVFCTIIIVLLVVIDVTNETSCVASLFNQAVTSAYDISLILTTFCVIAITILLGKKLNTSPHAALLFHFTTTLLLLEIPLLLITSLKYAGKEKAGNTVMEANNLFIAVHYILHSMFFIYNHEDYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6U8</accession>
    <name>A0A0D8Y6U8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6U8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6U8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10059" checksum="2E0C39E7214F8253" modified="2015-05-27" version="1">MGHLVVKCKNTQQNHIHLPKVSTFRACDARRKGLDRTLFGHIAVVFVDEVQPFLTGCVALDNQSKKKDFKTKKASIHVALSDTSKNLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6V4</accession>
    <name>A0A0D8Y6V4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6V4"/>
    <dbReference type="OrthoDB" id="5856035at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="203" mass="23196" checksum="D370D8B54C11DE0B" modified="2015-05-27" version="1">MIGRRLDEEQSHEQAVFRKELSTMDYIHTTTRLIEVSREYKKSLCLTFIGFEKAFNSVETEAAIEALINQALPTPYIKILPKHYFAKLKKKYKASKKGVKAGSHLTAKHSSLLNVSCIRLNARPMICSCESLALAALEHITWCIILTIEYCASTATFKEFISEAVQMRLMDTYCFEVMFFVLVMVKFLLSYGMCRNSSPTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="323" mass="36478" checksum="A213B9073246D2BD" modified="2015-05-27" version="1">MDKCRLSRFTGTAAVLLILASFTTSGNELDLRFRKELGVVMNLVGSLNTTRSTDVTEISAPKLPPSFVDILFKTGTSAEIHFTPANIEEFNMKNEGCMVYVCLEEKISSSTCQKIRSDVGTTTAAVEMLQPKETYFTTVTCHNEVNGPFSSWIMFVTPDKVKRTIPLRVQRTDCNVKVRLDEIDSLNVELFWNFTYENGSVFPETNIRTLKLQAHRHNEDDTYEKKLITEDKSIEHIVLGISPSYTFDIGCYFYSLNVTFTDGKNLFFSTDEKCYGFGSVSYIVLFCAIAISLLLFLFIIYHDAAQVRLNSLQITPTSSYSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y947"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="217" mass="24627" checksum="3DA41AFE6065244C" modified="2015-05-27" version="1" fragment="single">MTQMKQKTTTLKKTKSRLPLAERICRLPTLVVSPDDGDLQLAAVQLLTTPTSTPTLSPSLSSHGGEVMRSVAWTDDRGVILTARRQTTRKIQRTHNGEHDMIRIRNVSFPQVTPNKKVQSRKEKATDPFDHRLPNSFLPPLQYQYNEKNFKTTEIAPLQPQKIRGNRAESSSTICSTVIAKTSLNNTRVRHRAVDEHHFRRTPRISVNVDTAVQTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y951</accession>
    <name>A0A0D8Y951_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y951"/>
    <dbReference type="STRING" id="29172.A0A0D8Y951"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="397" mass="45585" checksum="6B7992D467BD4B75" modified="2015-05-27" version="1">MPKHIIKVFISLKDEFTHENVCEPTSSPKYMTVVSTFASIAAARGDIYGNLNKCYTIWRDKIEPNVRNSTKKHTYAELPLRLAACFLLNGDYYKALSCLLHSINLESKNILPRVLALRWSAFLGEWEMAEMALAFENAKFMQKDVEDYFASHLILTKEFVKYYVDFNRDHNTRSNSGTSLLKMTHKINADTRTTFLTFEAQSFANWIYSFNCLHRAVVKSEGVMKNRIPGIHKESESIDFRKLSSDVNDFLKACASYAEFCELRREYSIELLNVGMVHDAAFHSQLGLWSALKIGVFFRIQQFVNVNTLIRQCVVQVEFRKDLQFCMNIIRILYLKEPSSKNVFGGSKQKEVLPDDSEMSLLLTAKSPMGNRLFPASEGQKSVAISIMESFEDLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y961</accession>
    <name>A0A0D8Y961_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_01071</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y961"/>
    <dbReference type="STRING" id="29172.A0A0D8Y961"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GS" evidence="16">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="123"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH52727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="522" mass="58379" checksum="AD4C09117DEF4F18" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9S8</accession>
    <name>A0A0D8Y9S8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ANTH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_00826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Binds clathrin and phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9S8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9S8"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000017">
        <property type="entry name" value="Phosphatidylinositol-binding clathrin assembly protein LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="11">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="413" mass="47014" checksum="92F2C3BF919C710C" modified="2015-05-27" version="1">MQTIEKALHQPMPFTTGGQTISDRLTAAKHSLAGSQLGKTICKATTEELVAPKKKHLDYLLHCTNEPNVSIPSMANLLIERTQHPSWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLGNFLDKNSTSGYDMSQHVRRYGKYIGEKIATYRVCAFDFCKVKRGREDGLLRTMHTDKLLKTLPILQNQIDALLEFQVSASELNNGVINCSFILLFRDLIRLFACYNDGIINLLEKYFDMNKKQCRDALDTYKGFLTRLDKVSEFLRVAESVGIDRGEIPDLTRAPASLLEALEAHLIHLEGGRPPTSVGINDQVCVFNIFSVLMFKPCIFIPYSFAVMANEFQYPSVQAQVANFSLVGGFQMQPHVGDAERNRYIELEKEKLRQFEEQKRQQRSVGMFIAVVYHYLEISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAJ8</accession>
    <name>A0A0D8YAJ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Zinc finger, C3HC4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_00719</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8YAJ8"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000028">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1246"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="1304"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="912"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1357" mass="155659" checksum="4830EC9F0C2FBF23" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="240" mass="28223" checksum="7AF4BCD9AD4FB37B" modified="2015-05-27" version="1">MEFREDQKINQANEQAEGFFMIYSEDFTSHLKEYRNFKNSKKKTPNSKIDGKQLRRSKRQVIYEDVVDDRNDDSDAEEAILRRQLEQLTDDELASLSHIARNDMNRYVKPRYVTVPQYEIIEIPDEILDNAVMEVYPRDRRSVVPVEWSEVHEPEEAQYSVGDAILPQARIRIDLQMSSVLAILTSLWDRETGKRDYFAVPQEAVIEALKQEQDEQELRDRIAELAQILNERAYRGGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBZ3</accession>
    <name>A0A0D8YBZ3_DICVI</name>
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        <submittedName>
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    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="13">HannoverDv2000</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
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    </dbReference>
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    </feature>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="232" mass="26340" checksum="E0DE29DEC2DBBD34" modified="2015-05-27" version="1">MKFVEAIISLLATLTAALELDLTVDVPPGKFQCFFQPVDINKHKIMEVDYQVVDGGDLNINFLLLFEGAKIYEDLMKTDGSHRVNIQANGDFQICFDNSFSYQTRKLVFFEIFLLNEKGEADERDVSKMGVREASANWEALGVPIANFLDSTNRIKSQLNKVEYYQAILRAHEARDRAIMTANFDRVTLWSSTHTIVMIAVGLLQVFLLRSLFEDNSKVGRLLRKGKVDYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH53734.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="303" mass="29487" checksum="3BC7A7B66BB1F7BE" modified="2015-05-27" version="1">MIDDDSKRLEAEAVALRRVAFVGVAVSTVATLVCVISVPLLYSYLQHMQSVMQSEVDFCKLRSGNIWREVTRTQVLSKVSGARRERRQAGYSSSGVEGSIESASQNVCCGCGISPPGPPGAPGQDGESGADGQPGRPGKNGPDGPLATPPPQHEFCFDCPEGPPGAPGNPGPKGPPGAPGVPGSDADGGNRGPPGPPGPPGPPGLDGAPGNAGSPGAPGKIVEVPGPVGPPGPPGPPGLPGPDGQPGENGAPGPDGDQGPPGDSGAPGAPGQPGAAGQDGASGERGASGGCDHCPPPRTAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <protein>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <sequence length="352" mass="39478" checksum="26CCDEA803B5911B" modified="2015-05-27" version="1">MYRSAESGDAKKISKRDMLSEAEAKLKALSLEPARPLMAQNVPVGTIGEQFPVQTNAFAVDLKDPMTFWRYSITISAEIKDKRTVYFTKKSNDDYLVTSRNFKCKVVFDAVLSKYKQFFGDSGQLWYDGQSILYSGSDLFKNEEKTAKKFEVSGHDCYEKSLSVFETIVFDIAPVEENYCITLTEKALIESSCNLDLSKNDHSLAQLMEIIFNQIAVMNPKEHVLFDNGKAFVTHPWLHGFNEGDCPDVGDGKRLHPGTQKSVYIIEGPKGRGSSIPAIFIDSHKAAFHEEMSLIEKAKIIVNSNLSKKLSKLDLEKLNSGLKGLYFYTKYAGFESDHKIAAVVDHTASDTT</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <location>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717280">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="31310" checksum="BC4CBB30ABB7BE83" modified="2015-05-27" version="1">MKDCELKKISVANAYEKSSSYPNTIKSYLITVCQKLDMSHTFERNGSLSQAQNFERMQALLHQLGDMVSSIDENMIETSRGYDSGVAGSNRSFVTGTGGVVTRSMARQYKSRQSRQPRQADTGIKKMQDIIKQIEQILSRTITEMSETPRERDGEAAVVKERLIKNAVDAATQSLLCAGIQSFEDPNEIVSRLTKAVLEACKRQQESESQQQFGHHPKQQPHVLEQLQPQQPDHEQYNHLQRLDLLEESLMNSFRAYLVALLKVLPPSLHCPANHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7V5</accession>
    <name>A0A0D8X7V5_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_14416</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721591">
        <property type="protein sequence ID" value="KJH39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7V5"/>
    <dbReference type="OrthoDB" id="5808628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="10923" checksum="A51EA6860A7BF2AF" modified="2015-05-27" version="1">MAAARLEEVENRQRTLLANTDNRFSEGIDPVLSLRHSIAAIDARLSSNKATEEEKTDLEKLAKDLRIFLTGLPDDVRFHEIIYIHHTTCRTFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X844</accession>
    <name>A0A0D8X844_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717036">
        <property type="protein sequence ID" value="KJH40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5834577at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15440" checksum="135DAAEF1F559B18" modified="2015-05-27" version="1">MGDISLNTRYLDTNRGIIKILQIVAGFIICSLLCAQWYGGRSCFGEGRLGFCSGLNFICVVINIVLLVLNFLNIGAWGLERIYSVVCTVLFLIASALVIWFIIEYNTSRSTLIASAALIICEFFLFLWDVKILQGEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8U6</accession>
    <name>A0A0D8X8U6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_14026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718224">
        <property type="protein sequence ID" value="KJH40059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8U6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8649" checksum="DBE8D5B332E3443A" modified="2015-05-27" version="1">MVDKTTNDSFVENISFANRWIDSMMDSDRALKHWVLLTVMRGVLGDILRRMKQESSQYNTLRTLTLFVISFGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9M8</accession>
    <name>A0A0D8X9M8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_13565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN717176">
        <property type="protein sequence ID" value="KJH40477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5786116at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF793">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="15">
        <location>
            <begin position="173"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="286"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH40477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="425" mass="47864" checksum="B168DCE191A29FAE" modified="2015-05-27" version="1">MRNHVDMVVDHVNKNGDSIEEVNEHNRIDKALYQSDMILSEVQTEEIIQEIEENAENRAKRQAMNLRRYPKSRWPNKRVYYSYVNASARAVMSFEQAVKDWSNATCIDFYQNDTGILQAYPKPLQINNAQKIGVSENPRIIVTSGRGCWSHVGYIGKKQQQLSLGRGCGTAKMASQFNKQSEASNNNYNLTYDYGGVMHYGPMSVSKNRKPVVITRDINYMPTLGSPMISFYEKLMMNVHYECNDCTKETSAACQNGGFPHPRNCMICICPSGYGGDLCDRRPDGCGSVLKANESFQSLVDTVGVDTIPPGRVQFYMCHYWIEAQPGEKIEVILDSFSRGFQVEGCKYAGVEIKTGSDKRYTGYRFCSPSSSGTRLVSTYNVVPIITYNLRRPSTARLRYRSIRPDTDALESTSMPVTSTPLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9R2</accession>
    <name>A0A0D8X9R2_DICVI</name>
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        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">DICVIV_13682</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717290">
        <property type="protein sequence ID" value="KJH40369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9R2"/>
    <dbReference type="OrthoDB" id="5799527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="25282" checksum="5AE8CC5A96F62EB5" modified="2015-05-27" version="1">MAFGTHAQRAAVISAGVGLSLVLFIFLSVFFEFDWYHHEKGVDIGALVGLLLFLIVGMSIHWYVVRGIKLGQPKYLVPFIIVYAMTLVIEAAFFIFVVNHIVVLNYLRPMPPQSSSGYLIVTAMFIFTMGVQGVMLTAVVRCRNYLEKRQIHDLEMHVAEKSKLQHPGITIVFGSGNPDINTLSSTTEPRANVADAPPSYEHATQSANGTRSVAPVLQRTVLQAEDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9X4</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717217">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5791021at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16122" checksum="EB473881BA09E3C2" modified="2015-05-27" version="1">MNLEFLRTLHGFINLLQVCFGFAAIFASSLIWVDSSVYFQFIYKGFGWQTVILFILGITFLFALTILVFNVIGKDVLGTIGKKKLLALYAICLLLLIVSASLESWYIGLSTGYLHTRFIAVTIISWLLVFSYAVLFVVTLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBS8</accession>
    <name>A0A0D8XBS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719182">
        <property type="protein sequence ID" value="KJH39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBS8"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8372" checksum="387CBB1AC4383666" modified="2015-05-27" version="1" fragment="single">IVIFALQMKHVDFVKQKDKNQARYCLRKHDGDSVSTVGPCQSQDQIGYAPLPWVVNAEFYPLWARSTCVSITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC17</accession>
    <name>A0A0D8XC17_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716856">
        <property type="protein sequence ID" value="KJH41292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC17"/>
    <dbReference type="STRING" id="29172.A0A0D8XC17"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212:SF8">
        <property type="entry name" value="LIM ZINC FINGER DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24212">
        <property type="entry name" value="ZYXIN/TRIP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15532" checksum="F190B325A2170A9B" modified="2015-05-27" version="1">MNQCGYCERKIEQEPALFARGRLWHINHLLCDLCGCRIQEEEMFEEKEGTIACRHCYLNVNNPKCAGCNQGIDVKFVEASGKIWHRTCFQCTICLQPLNRTFVENDRGLPMHRQCFWKELLCKEIVTSFGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCK4</accession>
    <name>A0A0D8XCK4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716679">
        <property type="protein sequence ID" value="KJH42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XCK4"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10022" checksum="16D0542D8C9108EF" modified="2015-05-27" version="1">MVEQMARQLDVDVLVIGHSHECSVKEKDGRFYVNPGSATGAFSVIHDSPIIASFALLDVQSDNVVTYMYRLIGDQVKVERVIFKKTHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEN3</accession>
    <name>A0A0D8XEN3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5' nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716699">
        <property type="protein sequence ID" value="KJH42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEN3"/>
    <dbReference type="STRING" id="29172.A0A0D8XEN3"/>
    <dbReference type="OrthoDB" id="5800749at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="33012" checksum="D97476DE4DDB485E" modified="2015-05-27" version="1">MTFLLGHKWRSFFNITVVNARKPKWFAEGTVFRECTKVDTSTGAVKLGFHTGPLKEGVVYSGGSCDAFHKIVKARGKDVLYIGDHIFGDVLRSKKSRGWRTFLVVPELDHELMVWTDRRPLFEQLNQLDNTLADIYKHLDATARRKPQIHNILQKVKVERYADLYASSCYNLAHYPSFYFFRAAMQLLPHESTVDHASVVNSSKKDLLERKETIGQQVRGWTQKTSNENEFCHEEEEDEQSISDGEVHMTCTLRHSKSFSDDVTEHEVADTDIVVVPPAYVEQEQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEW0</accession>
    <name>A0A0D8XEW0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_11734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716685">
        <property type="protein sequence ID" value="KJH42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEW0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEW0"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15934">
        <property type="entry name" value="7tmC_mGluRs_group2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000362">
        <property type="entry name" value="Probable metabotropic glutamate receptor mgl-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <dbReference type="PANTHER" id="PTHR46671:SF7">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46671">
        <property type="entry name" value="PROTEIN CBG11221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="30026" checksum="7682F77608564B6A" modified="2015-05-27" version="1">MLISSLRPIRILITHSTKSCILILLLTITVFLLVIDYLEELYINKHTDRTSTELVELDSTASTDVKLLKESSSPSTLERTASGKAVTQLASLESIYNIWRARRRNETSHVDCGRVLNEDKDYVKLIVGKRPKLIPQVLDMNCSTIRGRLNPINLLKPLAFGVAHVRIVYESYQFVEDELISSYHPQNFFCYSVDKKSPAKFFNDINNLAECLPNVLISKQRFDITHGGKFMNHAFYSCLKSLISHSGWEYAILLQVNLSRVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHW1</accession>
    <name>A0A0D8XHW1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHW1"/>
    <dbReference type="STRING" id="29172.A0A0D8XHW1"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="165"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="40116" checksum="2AC6573C9381C9A1" modified="2015-05-27" version="1">MMESYDYTVFDWTTNLMNTLKLTSSELNLKAVLMNGQTFRWRNIGECYYGVVEGLLLYMKQLDDETIEWSCLGRSDSSSDIDVSKKLHEYFQLDISVENLWDEWCAREPFMAKLRSIKELQGIRILKQDFFETLIAFICSSNNNIPRISKMVNQLAIMYGMPITLHRPTVDYEVVRHFPELGFAFPTLSQMVNENNLCENLRKQSFGYRARSVSETVHQLSSMPTIELSNLRSLPYEHIRKFLLGFTGVGLKVAECVALMSLGQHQSVPVDRHIFEITKKYFMPSLKNSSLTDSLNRRIMDFYKKKFGAYAGWAQAALFNQQLENFICDLFVNEPVSKKSRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI85</accession>
    <name>A0A0D8XI85_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716718">
        <property type="protein sequence ID" value="KJH42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI85"/>
    <dbReference type="STRING" id="29172.A0A0D8XI85"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17534" checksum="2D54532CAE1FD978" modified="2015-05-27" version="1">MEPRRKRKLDLRFRSLTTAFFRDAMGFILIFDITNEQSFLNIRDWLSQLKVHAYCEAPDIIICGNKADLENRRQVSTARARHLADQLGLPYFETSACTSTNVERAVDCLLDLVMQRIQQSVETSGLPLSGECSHLKKHHSIPIVQLRFYSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIB9</accession>
    <name>A0A0D8XIB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716555">
        <property type="protein sequence ID" value="KJH43482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIB9"/>
    <dbReference type="OrthoDB" id="5849824at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
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        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10497" checksum="524B178ABD91FFEC" modified="2015-05-27" version="1">MPIFLIHKSQSLCDADSGVDADDLMASGKTNSNGEFELRGYTEEFTPIDPKLNIYHDCNDFKRLISVANRLVIGTTSISYPCAYYKKSFDFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIY7</accession>
    <name>A0A0D8XIY7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716534">
        <property type="protein sequence ID" value="KJH43692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIY7"/>
    <dbReference type="STRING" id="29172.A0A0D8XIY7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
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        <property type="entry name" value="TFP11/STIP/Ntr1"/>
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        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="713" mass="81808" checksum="0569878790A41911" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJN0</accession>
    <name>A0A0D8XJN0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BED zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716511">
        <property type="protein sequence ID" value="KJH43962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJN0"/>
    <dbReference type="OrthoDB" id="5871196at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="23471" checksum="3C3382969C817F56" modified="2015-05-27" version="1">MTKHLERHHQQDYQQLIVQIKQYRQQKAPVSSGVSSPESHHQPCILSMNQYMKSENYAQQLYSQFDRDDVLRNCSGYDRHDNSFVWQRGHWNQWTSHDPAASGIDMTGVLHGCLGSPSNGWGTVTPSTSASVEKPYMKRNRKTEHPVWEYFKRTADGNAQCGICTGVVKSPCSSNFMRHLMRHHSSEYNDVYVKWVQKRGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKB0</accession>
    <name>A0A0D8XKB0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716434">
        <property type="protein sequence ID" value="KJH45010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKB0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16880" checksum="AE0B18ABD9A14F2D" modified="2015-05-27" version="1">MIMVTISSFTFCNSSVIEKVAWQKLVATGNDEQKTRMAVWYRAGKCLTQSIIYYVFYIAAMYCQFPLIDCTSRSDLTRDRPQHSKPQFCEIMDQESPKALCFIIISATRRTHPRYEKQPGKSTFLDWRLLELEVDKRIYNRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKD1</accession>
    <name>A0A0D8XKD1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716628">
        <property type="protein sequence ID" value="KJH42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XKD1"/>
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    </dbReference>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13342" checksum="33BDE8483BEDA45A" modified="2015-05-27" version="1">MRNCPSPGVPLSTHVPPSTVEAIRIDISRTFSNNQYLRLERFRNGLGRMLYTLAQYVPSVGYCQGINFVAALILLVIKDESKATDLLIHMVRQRQDYYNDTMSGLRRDTRVLQVILA</sequence>
</entry>
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    <accession>A0A0D8XKT5</accession>
    <name>A0A0D8XKT5_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">DICVIV_08759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="11939" checksum="9508108D8A1AC8F3" modified="2015-05-27" version="1">MLVKSLRVPPGQPGSAGESGRPGQNGPPDDRGEIGSNGNKGPRGPLGQPGQQCKNSRASEVGSPGKNPMIGAPGTADRNGDMGPPGSPGMPGSPGIHRCPGKDTGYCVSAAQCTQKRAKA</sequence>
</entry>
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    <accession>A0A0D8XKT6</accession>
    <name>A0A0D8XKT6_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716474">
        <property type="protein sequence ID" value="KJH44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKT6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7857" checksum="0D1D716F4D6C58AA" modified="2015-05-27" version="1">MLLAFPKQQVLLRNRDVAAEVLKMDVEGDLLPALISFIKSYKVCQVGSLFLLKNSTCFSDLVMINPDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKU9</accession>
    <name>A0A0D8XKU9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase</fullName>
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    <gene>
        <name evidence="6" type="ORF">DICVIV_08735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716419">
        <property type="protein sequence ID" value="KJH45238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5874773at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000629">
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
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            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23205" checksum="B52F3107A5132F30" modified="2015-05-27" version="1">MNYVQLLPIQGYSTSVLLSGENLLVYAPTGSGKTAAFLIPAIELVIRHNKNEGRRADHPLVLILGNTNNLMLQTFKFACAMAGYDPSEEVANTHVRIFNLFAGSGMSRMRNMMKIDHEIVIATCGGVLQAFMYQKLDLSNLKMLVIDEADKMVDESRGFGYEVAQIFSHVPKDVIVAEFSATFCEKNNQIQLSDLDKKLFRWVEMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM80</accession>
    <name>A0A0D8XM80_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716440">
        <property type="protein sequence ID" value="KJH44904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM80"/>
    <dbReference type="STRING" id="29172.A0A0D8XM80"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
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        <property type="entry name" value="Reg_chr_condens"/>
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    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="278"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="416" mass="46726" checksum="04176C00999FF5C9" modified="2015-05-27" version="1">MNVRKIKHIAAGFGFSLFASKDKLFGSGLNNRFQITTHIKNAGLRLQEYYISAKRIHLPIGEFFPKYESCSMCTVLWIHHLFSRKSGDVFAFGLNEDGQCANGSYDIQWKPSKIMGDASGEKITSISGSSDTVLACSENGEIFIWGQNEYGQAGMGVDSVQLNYSRYIPFPGGKISSIGSTSSSCVVSTERGEVYVWGVGILGLGPTMQKLDRPVLMDPPLFGNEKVSNVYAGNTSFGALNAKGRLFVWGQNRYGLLGLDHGKDQYFPFEVFFPYDVKYVSLAGLVVFRRESNRVEFLLLQASYPPHHWTPPKGHVEPGEDEWVAALRETKEEAGIPKDCLKIYEDCHETLKYDVNGVPKTVKYWLAFLQNSENVKLSNEHQKWKWAELDEAIKIAEYAEMGALLRKFKAYIDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XME6</accession>
    <name>A0A0D8XME6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716386">
        <property type="protein sequence ID" value="KJH45793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XME6"/>
    <dbReference type="STRING" id="29172.A0A0D8XME6"/>
    <dbReference type="OrthoDB" id="6022609at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000291">
        <property type="entry name" value="Transmembrane matrix receptor MUP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
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        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="511"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="570" mass="64316" checksum="20709D917A1C25D2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN51</accession>
    <name>A0A0D8XN51_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716370">
        <property type="protein sequence ID" value="KJH46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN51"/>
    <dbReference type="STRING" id="29172.A0A0D8XN51"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="178" mass="20640" checksum="B38FA0AE1EBDD9DE" modified="2015-05-27" version="1">MATAGQDNMIRVWAARSHLKYFVQMRERYQHKNSSDSRNSPSEVFQAAVHDIESFRPPSSSGSNAQGRIEQYLQGHTADILDLSWSKNYFILSSGMDRTVKLWHLSRNECLCCFQHVDFVTSVAFLPKDDRYFLSGSLDGKLRMWHIPDKKVAVWNEVPVSLLFLIPFFLSVRFRGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP63</accession>
    <name>A0A0D8XP63_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716399">
        <property type="protein sequence ID" value="KJH45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP63"/>
    <dbReference type="STRING" id="29172.A0A0D8XP63"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024201">
        <property type="entry name" value="Calcineurin-like_Pesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF32">
        <property type="entry name" value="UPF0046 PROTEIN C25E10.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035808">
        <property type="entry name" value="Pdiesterase_Brain_239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="279" mass="31589" checksum="0743B9F3FF82B142" modified="2015-05-27" version="1">MDNYITVDPLSNKPIECWKKYQRQGRIAEPAKTLRLDTPIFDNKVRFVCISDTHEKLDEFLTLIPDGDVLIHAGDFTNYGDLGEVIKFNAEIGMLPHKYKIVIAGNHELGFEDGEEMNDKQLAGLNMLGINKAYELLSNCTYLCDRTIEVYGIKIHGSPWHSMPGYSFYRPRGQKILHKWNQIPANIDVLITHTPPLGHGDFNSWNKMDGILAGDVELLNTVEQRVMPKYHVFGHVHQMHGATTNGTTTFINASLCDHKLRSAYDPIIFDIPLPNGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQM0</accession>
    <name>A0A0D8XQM0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_09313</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX4/VASA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KN716457">
        <property type="protein sequence ID" value="KJH44666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQM0"/>
    <dbReference type="STRING" id="29172.A0A0D8XQM0"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="227"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="436"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH44666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="661" mass="74788" checksum="3C72D9170D8F3CD3" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQY1</accession>
    <name>A0A0D8XQY1_DICVI</name>
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        <submittedName>
            <fullName evidence="7">Putative chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716365">
        <property type="protein sequence ID" value="KJH46194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQY1"/>
    <dbReference type="STRING" id="29172.A0A0D8XQY1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
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    </dbReference>
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        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
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        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK00290.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="648" mass="70481" checksum="3842734D3940B1BC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR84</accession>
    <name>A0A0D8XR84_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716441">
        <property type="protein sequence ID" value="KJH44886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR84"/>
    <dbReference type="OrthoDB" id="5871872at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="33767" checksum="195A18696AE46024" modified="2015-05-27" version="1">MESLETILHDRVHNQKWFTARGLVVMSRVTGRTPQTNAKIVALMILYFLIGQNAWVVCNSILVIVPLLLTFTFPSERPQADTMHVYWIIAFIVSAYDRMLETFPLYYTGKLCILLSLLIDSSALSEQLKILFKMPVKSEKSSMDEKVRGKSESTAWDQSHGSSRLESSRADTPISSARSPLTAIGHVSDGMESKSSTLGAPTPYDAVPFVNTKASSRDIVRVTKESKLTKQRDHEYVPSTYIGLPKPVDKHHVTSIRVRADGKSKPRTPKNQRKTSTSKLTADNKNSSDDDDYFALPKSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRD9</accession>
    <name>A0A0D8XRD9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716437">
        <property type="protein sequence ID" value="KJH44961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XRD9"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002283">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="423" mass="46579" checksum="A86A59CD28EDDF0D" modified="2015-05-27" version="1">MVLRTESDRVPQVLISQASTDLRRTRSESQLATKLPDTVSMSSSTSAGFEDEILSVCTMSSLESEPVVEKLLPSFEEVIDANDTLTQSLLTPRAKDATLTPGMTISDIQKYADTAQTSSMQGLGTESASSFTSSLSFRTEDDLDENGITRNQTASTRKQRLHATLRASKRRVLDLMQKRRVGTFSCSETTEIGADAMDLKNAANPANEPSLTPTGKRSPIETQVSDRKEKKKKGKRRSPSAQYGQLTPSLQDSPTASTGFAHSKITKFMPLQENVVWKQSLDYDLDGISSSSPSRTSKYMNITIHAKELPSPIHDSGTSCGNQLTAVSEVESSQDILLGYVSLYIPQILDDCQLTLSNYHREVYQLKPPTDVQSIIETSASEFCRHAGYDPRLCYGDVTLGFRYFPNGFPHKVAALSNEERFA</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        <text evidence="1">Belongs to the E(R) family.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="144" mass="17007" checksum="749545615C4AF7A6" modified="2015-05-27" version="1">MVHTILLIQPTMRPDSRTWSDYESTTDCLEGMNVFILVQHLLYCLENNTRLYKEQLLTFNNVHFVDCDTIVLGICKIYEEFLKKQNPSMASITYDVSHLYEFIDKLSDLSCLILDTDTCQYVPHNKDWIKEKIFVMLRTQARND</sequence>
</entry>
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    <accession>A0A0D8XSD6</accession>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716340">
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            <dbReference type="EMBL" id="KJH46692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12381" checksum="6893F2D04AAAFFC2" modified="2015-05-27" version="1">MSPKRRSIDVGSSKARIAMSNSFFGHLLPTAVTGSGCSTEHNCFGQSGVVCSIEPFSGCIYSNSKVDPRIQRTEIDGKFFACEECRHVGECHDVIRSMIHNWDKIIQRQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTH9</accession>
    <name>A0A0D8XTH9_DICVI</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTH9"/>
    <dbReference type="STRING" id="29172.A0A0D8XTH9"/>
    <dbReference type="OrthoDB" id="5841843at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="155" mass="17301" checksum="7C72258DFAD2A59D" modified="2015-05-27" version="1">MNKDSDSDRCDNKCFIDKETCDPKEINLVRPLLPTGIPPIRVTPWSNAAKIFNTAKSTPTTTTTTSTTTTTTTIRTTSAAYSKTVLSFPNMRKTKSHPKLRLAAMNTSMRSRCRITYPRKKTIGSRVVPLLVCNSAYTIFTSLLLLILVLHCILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTR8</accession>
    <name>A0A0D8XTR8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTR8"/>
    <dbReference type="STRING" id="29172.A0A0D8XTR8"/>
    <dbReference type="OrthoDB" id="5866180at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="768" mass="86944" checksum="F4F3CE076A3B98BA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUC7</accession>
    <name>A0A0D8XUC7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="14">FTase-beta</shortName>
            <ecNumber evidence="2 14">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_07944</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of FNTA and FNTB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 14"/>
    <dbReference type="EMBL" id="KN716375">
        <property type="protein sequence ID" value="KJH45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUC7"/>
    <dbReference type="STRING" id="29172.A0A0D8XUC7"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000007">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 14" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="15">
        <location>
            <begin position="65"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH45986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="415" mass="46229" checksum="365826835DC21313" modified="2015-05-27" version="1">MMCNTFRTCREEFACNDDGYFTFTSTEQVSYDFMLSKRVEDLVNDQYLTYKSSEQRNVPNSSPVLNRNLHVDYITKSLREVGRGYSRSFLLCQGLDASRSWMCYWGLHSLNILGVPPSHAQKGEILAFLKTCQHPDGGFGGGPSQYAHLAPTYASVMALASLQMEDALSAIDLKSLSRFLHRMKQPDGSFTMHDGGEADIRGTYCALAVAALCGIMTDDLKDGVAEWIVTCQTYEGGFGGEPLAEAHGGYAYCAVAALVILDRYRLADSELFLRWLVNRQMRFEGGFQGRTNKLVDGCYSFWQAANFPLVDGEMAREGRFPTEGLFDARMLEEYILMCCQDENGGFRDKPGKARDLYHTCYVLSGLAVAQMYSSSREPDGILGGSQNIVEPINPVFNLTTLSEQFAVSFFSKCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVA9</accession>
    <name>A0A0D8XVA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="9731" checksum="79AB542E80D4621E" modified="2015-05-27" version="1">MSTQARIRGLPSAGLLSIYASFCPPIDSYENINGFTVFNGSREYNFLLLLDSIAGLLEDVDTTANVSYQLDRLSHLAQIFQSTLGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVD1</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716295">
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        <location>
            <begin position="1"/>
            <end position="16"/>
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    <feature type="chain" id="PRO_5002335984" evidence="1">
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            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="17182" checksum="1BBD05BF15A6E8D3" modified="2015-05-27" version="1">MQWLLGLSALISFVYSQLNCDILEPECRALYRSRTKFNDIRRQIKNQCNYQDIWLIPGRADASCTRPGARRLLEISPGQIHIKPDVVRLPGCFTLEIKNLRLKEDTDAFGNSFFAKAEYQWWNVKDFSNLKCQNASNNGCGGYGNNWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVI6</accession>
    <name>A0A0D8XVI6_DICVI</name>
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        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716293">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="25669" checksum="264EDA368CC7CAC5" modified="2015-05-27" version="1">MSTLKQLLLPQPNLQRVQRILEGRHFRSFLKAFIFIEIVTVCGLISSVYVVVMKAIMRLKILWEVETLPKVGYFEEFAVSSSSELCTELARTMYVEGFAMNLIALAMQYCLHLQNPDRSGELGSSVAVHYSPNGCRYTRGESRAPENKTLTDEFVSSFTSYRVDSLFRGPYSELVPLDLVTTLGFLENATESEIEEVALMIKSEHGDKCIALTINEVDPLELGLLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVR4</accession>
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        <submittedName>
            <fullName evidence="9">Putative 4-hydroxybenzoate polyprenyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06064</name>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="35746" checksum="3022F217F0CF1212" modified="2015-05-27" version="1">MFTREKLYNGVEKYADSFGSHLEDGRLSSVASSAANNNFNIMVERTKMRPLACGSLTQKQALVLLASLLCASFSVLMRLNWFSVAVGSASMLLVVGYPLAKRYTYWPQFILVWNNQFLRLDIQTCNKLVAGATLNWGVLIAWAEMLPQDQFYTYLDNLAAGLTFNWGVLLGWSAIRGSLSMASIALYLAALQWTIIYDTIYAHQDKTDDIMIGVKSTALRFGRATKVWLSSFSGITIAGLGIAGFLAEQTWPYYLSLAGTSAHLMWQVATVNIDDSKDCWRKFKSNQWIGVMLFVGIAAGTLLKEKKTVNENIQLDGFDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVV9</accession>
    <name>A0A0D8XVV9_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XVV9"/>
    <dbReference type="OrthoDB" id="5835329at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31571" checksum="C1AA5A076CA84C02" modified="2015-05-27" version="1">MILYEPFDIICFRSLDAFIWDSTRLDFEAARHCQLRTRGALFGRSAYGVGLQKNSPWTPHITSAILRMTESGVMEMLDSKWIENKNSKCVVAAHKTPFRLSLWNMKDVFILVVGGVIFGVVCCIVEVIYGRKRSHRERERLLAVRYLKKWQQFVFEGHKPLSYNLSRPSINRRRLCLPRQNMDGQPVLHLSTFIPDLNFGRHPVVLFCSRCRTKSERFSLCLFNEFYDITRFSYRVTYVEAMLVYQNNEGLTYFCIIYCVNSIRSTQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVY2</accession>
    <name>A0A0D8XVY2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_05959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716287">
        <property type="protein sequence ID" value="KJH47939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVY2"/>
    <dbReference type="OrthoDB" id="5850701at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH47939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="379" mass="42548" checksum="749550EEDA11053F" modified="2015-05-27" version="1">MGEPNVPRVDSKVVDEICVSYPLPIGIERSVVLRILNGKTDFANMSAIELLAGGALNDSNLTFSEVEQYYVKQAARWPEHLDMVTIPAILPFPDPDDNSLHDLTQDVLLMSLMERISCEPLKQLPFKTTPLIPPLYPIQPIELGCNVNEDIINEVADVASLNRSTSTENNFVPPGAAIISMEANALEDLTVEQIAEFTRRLLDGKSLTHSETKQMLKSLENPCTNQKFMDLFFKLSDLELSKLIDLNVKVAIELIDLCVLNDQSIATRIMRIVQGMDVTVQCMEVVTRLYQYRPQLPREPLNDYVRYCVRYCLDATPSSNLNRVVRLVAITLKNLLKNGSISASELSLELREFGVRFCQHPDTTFLFNTVGSAQLKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW02</accession>
    <name>A0A0D8XW02_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nanos RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716348">
        <property type="protein sequence ID" value="KJH46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW02"/>
    <dbReference type="OrthoDB" id="5875747at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="26333" checksum="15720AF85811ECD4" modified="2015-05-27" version="1">MFSFAPFPNKVWSMNGHETMHESSTTSEDLDDTALLNTSWPLFYVGINEEVLWLQPTDQLRCRPKKPNNFMSKVESFAWFLAQFVTTLSIYINQENLCYCNLGKCCCGDRPHKANAFLRKVCSERKVPASRDYMFLKECAYCKGIGKPFVGHQKTSCPVLFAMRPCSLCGADGYENHTLSHCPYQQKVNLALKDEHRFGKETRQTKRYEERHELYSNNIVNSANLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWT2</accession>
    <name>A0A0D8XWT2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_07132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716334">
        <property type="protein sequence ID" value="KJH46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWT2"/>
    <dbReference type="STRING" id="29172.A0A0D8XWT2"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30585" checksum="53FE27F40F0C0D62" modified="2015-05-27" version="1">MRSDIVYGRFTGTVYSARAGHNLYGTDVEVDYRGEEVTVENFIRLLTGRHYPATPRSKRLLSDHQSNVLIYLTGHGGDSFLKFQDTQELTNVDLAYAIQTMYEDNRYHEMFLIADTCRSASMFEWISSPGVLSSSSSLSHEESYSYDVDDEIGVYVIDRYTHFTVSFLNREVKALNSTATMQDYLDSCSRRQCLSTVEALRAKAGRFLTTLPILSEVMSLIDFVLGVRKDVYPKEPSRVRVTDFFGSSRIIRQISEEIIVDDDWLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXQ2</accession>
    <name>A0A0D8XXQ2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXQ2"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF24">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20274" checksum="CB4E83BE17AAB87B" modified="2015-05-27" version="1">MLLKCYSIYFQFIMSSENKSEYAFTNASNPESWDDYRTALIDSTLSTKCSTITTAQDIDTKDISDDQTLKTARTAHIEETTYTFENESAISVFCQTFLPFLVAGLGSISTGLLMYRIQRTDLVCKVPEFIAICPPLQAMKGNLDMTFTSRLGTMAHQGRLRKHPGRIKRILRNYALLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY40</accession>
    <name>A0A0D8XY40_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY40"/>
    <dbReference type="STRING" id="29172.A0A0D8XY40"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF55">
        <property type="entry name" value="BESTROPHIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="21681" checksum="11123145AA3E514B" modified="2015-05-27" version="1">MFRWWDCCQLISWPDHLLYNVSALIRGNDSETRIIRRTIARYAILSSVLAWRSISLRVLARYPTDGHLLDSGLITEEELALFKSIHVRVDPHQKWFVPINWIQTMMVRCYEKGTLSHTNELRILLDVLEKYRNGFFQLFIYDWIAIPLVYTQVSTISVYGYFAFALIGRQFPIYNEYHEAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY77</accession>
    <name>A0A0D8XY77_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716259">
        <property type="protein sequence ID" value="KJH48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY77"/>
    <dbReference type="STRING" id="29172.A0A0D8XY77"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="515" mass="58321" checksum="D27BF398379D1D84" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYC6</accession>
    <name>A0A0D8XYC6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
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        </ligandPart>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="322" mass="37629" checksum="CF0D16B9AACC3C5C" modified="2015-05-27" version="1">MGTTVNSQTEDEIRKINEQVISQFFALRLISKHSVVKVFSFRFPWLWLEPIWYLSGFQSEFNRLVKLTNDFTRKVIADRKRRMDDTEFIDEKEMHSNRKKLAFLDLLLHMQRSNELSDEDIREEVDTFMFEGHDTTSSGIGFTVWWLGQSPECQKKVHEELDSVFGDSDRLPTSEDLKRLVYLEKCIKESLRLTPSVPLVARKLTSDVVIGETTLPDGLTVVVVPSTTARDDRYWEKPKEFYPEHFDAEKVSLRNPYAYIPFSAGPRNCIGQKFAVLEEKTVLSWIFRRYYVESEERYPGNQPSPELVLTPSNGVRVRLTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYF2</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716309">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
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        <property type="entry name" value="AAA-FAMILY ATPASE"/>
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    </dbReference>
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        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13154" checksum="DA36A09778F09CD7" modified="2015-05-27" version="1">MFDKSIHIVPGNDVESKADILKAASKKVNLAVDVDLYEVAAQCDEIMSGAELHSILSLAAMESIREQIHLIETNCISPSEVKGIISRQHFQAAIKKHKNELQSVRQAAKIDEHQDYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYW5</accession>
    <name>A0A0D8XYW5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716222">
        <property type="protein sequence ID" value="KJH49828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23511" checksum="A6FBEF35B1FD19CE" modified="2015-05-27" version="1">MNLHVLRFAAVTRFIDLMNWFKCRRSYCLLSVGNYTSGLIIVTWLISDYGDVLDALYCISSCLFGIAITGLYLYRPLFMLPDIIYKAAVSFCALFYSIQETDATGQKAVSHLILVMLAVGLLFIENYLLLQLWSSKQLESQRLAQRRPPPPTYDQLSTLELCHQTGSCPMPDVKYSDDVNRPETPPPCYELAVAVLRLSLQPRRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZA0</accession>
    <name>A0A0D8XZA0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">DICVIV_04043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="414569at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF3">
        <property type="entry name" value="PROTEIN C31H2.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="163"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="375" mass="42911" checksum="7598BEFEC05A37DD" modified="2015-05-27" version="1">MNGVADFHHVEFRVSNALQTSYWYCCCFGFQRFATNYCESSTCIAIRNGPVIFVIKSIRSSNREDLKQITVHGDAVKDVAYRVDSIDAIHERLVENDISILSPKTTYQDEHGSVNILQIQATDSDITHSLIEDKNYSGVFLPGYSPADDYPISSLLTKIPVVFLDHVVQNYPINTIENAAEWYRQSMAMQRFWSIDDKVTTSEFSAMKAWLIANQDRKVQMTLAEPVCGRKGRSQIDEFVSYNGGSGIQHIALLVDDIVANVTEMRKRSVEFLEVPSSYYDMLEERLQESKVELKEDIKKALVSKLLRELCILMDFDDNGYLLQLFTKPVQDRPTLFLEIIQRRNFNGFGAGNFKALFDAVEREQKRRGTLFEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZB4</accession>
    <name>A0A0D8XZB4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZB4"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9666" checksum="887D4211B97AE585" modified="2015-05-27" version="1">MSLIVMSASIVELTTSRNSQLDSLDIFRVVAILWVIVNHTGSEGRVDVLDRLPSANQFKDWLWLRKRLDLSWHSYYSKNGITTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZD7</accession>
    <name>A0A0D8XZD7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leishmanolysin-like peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716296">
        <property type="protein sequence ID" value="KJH47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZD7"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336249" description="Leishmanolysin-like peptidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36834" checksum="C597C23C82DDB301" modified="2015-05-27" version="1">MYIFLVALISHTISSCLSQYIPLSVTVIRPWEESTMRGIIEVSLRSAIRNLSTIISMVDYGIRNITKKSITKCSLSFERSKVVGVLKMAEHERSREIKQHFKNSFLLRTTSFVLLIENKRKLCQQHRQMMASAAPCGILSEQRPLFGIVNICQGKRWEKFHAGMDLFRHELMHALVNSVLITFVTFVDTVVFPNSVQLLSFNLFEEKKVILSSINFHGFGTLLPASNFQKSPAGVQYKWAVTWDGSSKQLATREFLDFATDAVNEAKKHLGCPSLIGIEADSVDKIHLNEYVFGNELMTPILSNVSNRFSYISAAILEETYIGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZF1</accession>
    <name>A0A0D8XZF1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716244">
        <property type="protein sequence ID" value="KJH49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XZF1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="642"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="440"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="821"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1497" mass="170838" checksum="C264A17C7BAA5671" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZK9</accession>
    <name>A0A0D8XZK9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_03934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZK9"/>
    <dbReference type="STRING" id="29172.A0A0D8XZK9"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF20">
        <property type="entry name" value="ARGININE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336073" description="arginine kinase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="146"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="37643" checksum="D70ACEF20B3D6200" modified="2015-05-27" version="1">MGHTKICWHTLFGNFLVAKSFFGSSADAATVKKIEEGYAKLNGPEGTKCKSLLKKHLTKDVMDKLKYKKTKLGATLYDCIRSGIYNLDAGVGVYAPDAESYRTFALLFDKIIEDYHGFSPKQKQPPVDLGEGKIHEFPPLDPKGKYIKSTRIRCGRSLAGYPFNPCLTQDNYLEMEKKVKRAFDSFTDRDLKGKYYPLDGMTKETQDKLIADHFLFKEGDRHLQAANACRFWPKGRGIYHNNDKTFLIWVNEEDHMRIISMQEGSDVGKVLERLIRGIKSIEKVVPFSRDERLGWLTFCPTNLGSTVRASVHIKLPKLTAKKKEFEVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZP2</accession>
    <name>A0A0D8XZP2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the CIA complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZP2"/>
    <dbReference type="STRING" id="29172.A0A0D8XZP2"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="299" mass="34258" checksum="9D79D216565ED94C" modified="2015-05-27" version="1">MTPFENQSDLFQQLVVERRLSLSEFFESRRPLFFSDSDIVKENAFSELGDLICSFPKDFLSEQQVELLLNFLLQQLDASIVAAPYCIRGINHLVLHSSNFPHGFEIPLFQIMFRDGNVQSWDPEKRLLQYIYEKFNKYSMLKFSSTILDVVPLGLDFVSAFIKTISGEQHPKCLPMVFRMFVIVAHSFSIGPLVEDMFEIMSWYFPIEFKQSSSGAPITQELLERGCIKCLTALPEFGPFCYLLIEEKMTDEECSIEQKHEACALLAEAVMVFRPDDIVNHLEPILGGLRAIGLNPKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZV2</accession>
    <name>A0A0D8XZV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716239">
        <property type="protein sequence ID" value="KJH49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZV2"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336096" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18816" checksum="1001B7244985AB74" modified="2015-05-27" version="1">MVVVVVVLVAEVFSPLGTVIVLEPVAAIEVASVDEMSPAKLKALRKAIERIYVSHLDRQVVVVAIDNLLYVPEYVSVTPQPARVRVVHFQPEAIVRMTYAEGYNINHPDSLFTIENPQPHSRETHSKRRIEKKYLINWFPFLRLYFRSGTDFRNNLRELHEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0K8</accession>
    <name>A0A0D8Y0K8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
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    </dbReference>
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        <property type="entry name" value="FBXO47"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36981" checksum="02CAC8B680A41E43" modified="2015-05-27" version="1">MVKQPPEMKLKVQCSSSALLSSRSSQWMNNIFRRVDGSRITSYFPVRKRVRQNVDEDRCKRFRHGMTICDVRFMPQTESSQETTPLILRCVEFQSEMNPLQHTDLRKSDGEKNCFTYGLVPVANSSSSVTGHLAVRIPTALGAFEELPSNLLHLLFDNIDVSCLISLCLTSSAWTQYALDYVYSNSFLQRVEREGLCFSENEGESSSNFFTLLDPFFCYGNLLKCVSVSFHSSKRIEILISFCERAFLCERIGNLGVGRVLHTMCSSWSYSERAKVLQAVLDWKGGQLKNALKQLSDHDPGSIPKLEMQRKDMESKSFICTALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0P4</accession>
    <name>A0A0D8Y0P4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716211">
        <property type="protein sequence ID" value="KJH50255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0P4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0P4"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="253"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="310" mass="34942" checksum="7614720CAD3A213C" modified="2015-05-27" version="1">MPKRVVSFADDVASGSGSVKRTAFNGKDNDEFDLPAGDERETEVEGQEDSTLDFDGSTKITAFNMKEDMEDGHFDEAGNFIFDKKEKEIKDAWLDDIDWSTVKEKAGDQWEILNDRDNDEVPPPTLNDIRRKEIFSTLVTFMKPNQTVANVLTTLKRAKGLTAAEERKMRWKAKKEGKSFEESESGKNTRLISGLVDELISAGHMDAYEWSREKFEFLLKKLDGTAVDSVDMFSDEPASVSSWNTQDNLNDEDQKWEYKESEAGEILGPFSSSEMARRQQNGQLSSGGLARKCGSASFNPISRIDFDLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y136</accession>
    <name>A0A0D8Y136_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_04084</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716224">
        <property type="protein sequence ID" value="KJH49744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y136"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12236" checksum="80AC8BB3CFD4C9A5" modified="2015-05-27" version="1">MLKSWLVSSPASCCVQAVSQLCCDVDAFEPAVVDDYCILRLDLTYSRGFPWSQKIIDQFKLLQIGGKPCTSLCSKRALSGFDSAGCFVLHIYRRSGGESPPAVLVALLSWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y181</accession>
    <name>A0A0D8Y181_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin Inhibitor like cysteine rich domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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</entry>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH49431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="551" mass="59179" checksum="DE5DA8951751B587" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4H0</accession>
    <name>A0A0D8Y4H0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4H0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="10719" checksum="227126B49849FDAC" modified="2015-05-27" version="1">MSLSSSKSVISDRTGSSGDNQESDVERKSLITDKDKSKSKGKDSVDVRELVKALKVVRKAKQRNVILFLYCLLFSNHSDPLDAFNGFVGVCSPAASSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4S4</accession>
    <name>A0A0D8Y4S4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH51009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4S4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4S4"/>
    <dbReference type="OrthoDB" id="5804354at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="294" mass="33014" checksum="D4DC6BA9DD0268BD" modified="2015-05-27" version="1">MVDKTGEINFVGLAPGNYFLRAILQEYKFEPSTTTITIKEGQHEYVKLRGKKVSFSAYGHVREMSGLPVAGVIVEALSEQCDQHHSEAATTQDGSYRIRALKPNCQYTVSVKGTLENEAAPHCFPTHFHVQMTGEDLKGLDMIAAPYHFNTDVAVEIEFGAMTIPSSYRLILQENGEIISNSIVRAPVSVFYHNNLPRDGREYSVRVEPDRHSQFFLAKTVFFTADAPVHVVRVPITMTRRSGEVEISVASLFALPFFGIIALGFFNQGRARELLRSFLSVIHPSSTFERKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y533</accession>
    <name>A0A0D8Y533_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y533"/>
    <dbReference type="STRING" id="29172.A0A0D8Y533"/>
    <dbReference type="OrthoDB" id="5840389at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO armadillo-like helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="40076" checksum="2B7CEA30B420ACF8" modified="2015-05-27" version="1">MSTFIVIDKKSGNVNEVVKHVVYDLKLPPNESYELIFEEPKAFLTSSNLHRVHHGFMLTVTAAAKYYVMQIDSILASRSNFDNIEWALSALESFSSQSSMFKPLLAISAIYVAVTTQRYWVEYNFYCPRQQARYTCYGCRAKREDSNVVLIALQMIEQLLNSDNAIIRQLVLAEVPPQSLIRHLEKSDERVALAALSLMNALHDKSDVLSREEIVKHLASVPFRTAISGSVLREGRARNTALLGYLVSLERLLIQEHTKLFGCAVMENEINALLVRFKIFLYLRVLFIIFFHCQSRDVVRAAATGEPQLNEWKEQLLTTHFGKLAIDTFSNYADQNAEDLRIVSKNSLCFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5T3</accession>
    <name>A0A0D8Y5T3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5T3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5T3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="154" mass="17501" checksum="B443CE1816E2325D" modified="2015-05-27" version="1">MLFRPGAKSFSDNAEDRRKALFKSANPSGPYSEIREPMHSHNEVQLDFLEQCMIGDEYKVISMLNANIVNTTYRHPINGWTALHWAACRGHQNVCLLLLRSGFSKEVKDTRGRTPWEVCSEGNIKLKEILEPESLYSENEIMSDSDLCAETVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y602</accession>
    <name>A0A0D8Y602_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Exocyst complex component Sec15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y602"/>
    <dbReference type="STRING" id="29172.A0A0D8Y602"/>
    <dbReference type="OrthoDB" id="5839770at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="25371" checksum="CF252CFB0DDB10CF" modified="2015-05-27" version="1">MLGKFHRLKIGWFIFHRTHVEVEQQIEVCIREKVDAFIELAQYDWELPASSGHASDYINDLINYLSTTFLSFTNLPSVLARHVCMQTCKHLSSRLSELLLSPEVRAISTGALEQFSLDVMQCEMFTARCPVAGFDHNTLPMTFAHLRQLLELVMSNDWTSYLAEYGQENGKYVRVNATNATQLLEKMIEFEKKSSGFFAINKGDRKKLLDTIIRQLRALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y620</accession>
    <name>A0A0D8Y620_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y620"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="91" mass="10964" checksum="39F8798812B24B76" modified="2015-05-27" version="1">MIPCSHASFHAIIPFMLTTSLPFAFFYLLKLYPLCLKLYTTNLFLQMKQITSTFEVKKVLNAIIYILRIIFIFNFKKEAYHYSREKRNFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6I7</accession>
    <name>A0A0D8Y6I7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6I7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6I7"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="364" mass="41095" checksum="B993057932692662" modified="2015-05-27" version="1">MKPYDTWKQEFIADRCCQENDFLKELLVASSPHVLLNLVLITYLLLGTVVLRYTDEAIGKEKFPPALLFSFTTITTIGYGSIYPKTDIGKLCCMLYCVVGIPLVFLVLSNNGQFIVDAYMIIRKSFGSKKTMSKGLPLWLSFTLLFLHSLVGGLIFSTWMGQMRFFEGVYCSFISVSTIGYGDLVPVPDNWTHTVAIIAFLSTGVVILSTLFETFGCYLQYLHYIGRRFTGTKDIEIWFGGRVLTVQELIALVADQFEVSPRRLRAILRDLDNILEAAYEDMSGITVLGDKSQTVLPSGEVSPDTDVESTQLYRTSSNSSMQRINVRDTENALHALRVIHHKLNKSPFCRPQRERQDLEVSNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6S1</accession>
    <name>A0A0D8Y6S1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_01278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6S1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6S1"/>
    <dbReference type="OrthoDB" id="9973372at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH52568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="358" mass="40189" checksum="0812C8D34259FD12" modified="2015-05-27" version="1">MEDEITALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGILSLRYPIEHGIVTNWDDMEKIWHHTFYNELRIAPEEHPVLLTEAPLNPKSNREKMTQIMFETFNTPAMYVNIQAVLSLYASGRTTGIVLDTGDGVTHTVPIYEGYALPHAIQRLDLAGRDLTDYMMRILTERGYTFTTTAEREIVRDIKEKLCYVAIDFEHEIAVASMSSSLEKCYELPDGQVINIGNERFRCPEVLFQPALIGMEAAGLHETTYQSIMKCDVDIRKDLYANTVLSGGSSMFPGIADRMQKEIQQLAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQLWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y788</accession>
    <name>A0A0D8Y788_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_02025</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y788"/>
    <dbReference type="STRING" id="29172.A0A0D8Y788"/>
    <dbReference type="OrthoDB" id="5918422at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH51834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="127" mass="13409" checksum="AE66F4CBE9B8FDF0" modified="2015-05-27" version="1">MSGRGKGGKAKSGGKAKSRSARAGLQFPVGRLHRMLRKGNYAARIGGGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKSAGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7C8</accession>
    <name>A0A0D8Y7C8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7C8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7C8"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="238" mass="27504" checksum="42AD621564E47682" modified="2015-05-27" version="1">MRQFYNLCKCFRCVYAIFSYIKFQVVPAIRLDDADWKVIQQNTFTRWVNNHLRKTGDCIQNLETDFSDGLKLISLAAVLSQKCWSQVNFRSQKLENVSLALKFFQDVEHIKIVNIDSSHIVDQNKKLILGLIWTLILHYSISMGWFQERFDGKSEDTPKQKLLNWIRSKLPQGMPLTNFTSDWNDGVALGALVSALLPGDFPNWKQWTPANALENTQIAMQIAEDRLGIVPVSIQFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7J7</accession>
    <name>A0A0D8Y7J7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7J7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7J7"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040022">
        <property type="term" value="P:feminization of hermaphroditic germ-line"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17974">
        <property type="entry name" value="DEXHc_DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="253"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="435"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH51959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="887" mass="102058" checksum="D75C2F642D54612A" modified="2015-05-27" version="1"> </sequence>
</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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    </evidence>
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    <sequence length="322" mass="35024" checksum="5DA19D08C4DC0E31" modified="2015-05-27" version="1">MYVQGGVAVASPAVVLTRSGSTIGGEPDRSNSLPLPPHQQSSISTQGTTYTAPSSSRHHDEAALPQNLFDELPAEEQSPPSPPKQRGVDKDGSFTPVQPEPPHLSDHTGRPPSQEAPQDPQCSSTSAGSTESQIVVPTDPTQGMDKSEMVRKSAIKDGEESDSATDKKPSDIHENTREQVKILVFRTVYSSYQPYNTIYSCLFSNISILQISSLPTDPPITNKSVSSNQNETQKRSERLELQGNQSHDISAHVQSMSCAQRERSESSLINNTLNVFQNARSSTDEELWFDVGIIKGTSCLVTHYFLHGDQSLESTYGVGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="125" mass="14170" checksum="C888E2CB37DC8422" modified="2015-05-27" version="1">MQPKSKLTPRKIGVQGPSIRKKEPTKTQQFSREELTELKRLSAILPPRAGKEQDPAQLVLNAANYIQQLVATVRVRVNKGTLPIGWSCNDLPSAYHYYQALAALPQTSTSTRIPRKKRRSIEKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="95" mass="11341" checksum="F67C8CD8DC87D78C" modified="2015-05-27" version="1">MRRIFQVILLSSVLLNPIVAQHFTKRESREKQCKVHRSPPVHHVMDQICLFCHEMFSHEAPNLRAQCRANCFRNDWFTSCIAIFSSKNRQERERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y849</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="16245" checksum="9394A439C0AC3C49" modified="2015-05-27" version="1">MMQKKRNQDTEKVVKTKQTSATGQVGPPLTCPLPDGAGYQVVLRNISHNHLTKGNPVLCSSKANNCKDGYECIQGLSFIGEPDGVCCPDQITTCAYSIFDHESGTLGRWGFDGTKCIEFKWDPEKPSSANNFKTKFQCENYCMNIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y958</accession>
    <name>A0A0D8Y958_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y958"/>
    <dbReference type="OrthoDB" id="5844480at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="23130" checksum="F2AD403D2545152C" modified="2015-05-27" version="1" fragment="single">ETIPSELSINTFDGETAGSGYGWISSIDAEPHCDLACVEESQRVELRMLNQQIESMKEQIGLCLNDERLITEFIEVNFMKEKESIKEGMEYSMLHEIVKKLENEVDELRKISPGTVSLQSPGTPQRHSTWSCTRCLEENPIVAYRCRCLFPRAAIDPCEAIKCNCIHCSQIKAYEIFQSRTSGDDDWLLLNKLPSENKVAKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y987</accession>
    <name>A0A0D8Y987_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y987"/>
    <dbReference type="STRING" id="29172.A0A0D8Y987"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000187">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="212" mass="24119" checksum="56EB9897A47150B2" modified="2015-05-27" version="1">MGRFFQRIFAHTNICPVLAAANQPPNLVVISQYMPFGSLYNVLHEQSSVVIDHSQAIRFAVDIARGMSYLHSLDPPILRYYLSSKHVVVDEELTAKLSMADTKFSFQEVGRMYSPAWMSPEALQRDPEDLNIRAADMWSFGILLWELNTREVPFADLSPMECGMKIALEGLRVQIPPGTSRNMCRLMNICLNEDPGRRPNFDQIIPILEKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9F8</accession>
    <name>A0A0D8Y9F8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9F8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9F8"/>
    <dbReference type="OrthoDB" id="5876240at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Hallsworth Pepin K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="34"/>
        </location>
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        <location>
            <begin position="173"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="366" mass="41777" checksum="E34ECA3650909A84" modified="2015-05-27" version="1">MPIENRHRRVTRRTLLTASTMQVIYLMTCLYLIYCRPFPQKHTNYDETTARRLLSLAAGAYASREQQEACLNRGMSSEEAYTILTTVVVQCDTMNNTCVGSHTKKHIVVVYRVHCISQHQLVAQGINTFTNFKDFFGMGKKFRGNASLKPIRGKASFNTPKKYMNSSNLLVFVSEKQILDYNITFTGHSLGGALAVLAAARTATQGYRNGDQITVYTFGQPRVGTAISQIFTIVSYGAICQKRMVVGSYRVVFRKDIVPHIPPCETYESWWYGEYYEDGTYCDVRAKIILIIIEQKSEPQGEDYSCSNGLTFSFDDWFDYINDHLHYFGVKISQYGEVSCDANMMNVEVSWLEKLVRMISVYIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCK9</accession>
    <name>A0A0D8YCK9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCK9"/>
    <dbReference type="STRING" id="29172.A0A0D8YCK9"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF88">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="32257" checksum="5CDE1B269C562AFD" modified="2015-05-27" version="1">MSTAEINTISDRSESERSSETLDGKQNELTKPILRLNMSILILVNLLNYMDRYTIAGVLTTLQSFYGINDANGGLLRTTFMIFYMICSPICGFLGDRYSRKRIMILGISIWVLAVFASTFVPANMFWTFLFFRGLVGIGEASYVVISPSIIADLFTGAERSRMLMYFYFAIPCGSGLGFVVGSSVAALTGDWRWGIRITATLERGAAEREKGELINEMVQTTYLEDLKSLSMNSTYIFSTIGYTALIFMVGTLSWWGPTAIEHYYAYREGLNSTNQLHLKVKARYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCL3</accession>
    <name>A0A0D8YCL3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCL3"/>
    <dbReference type="STRING" id="29172.A0A0D8YCL3"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF8">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="39943" checksum="3E662208BA533DB0" modified="2015-05-27" version="1">MCIPKRSNRSDADYKQRQKSKSGSNGSHSDSDSDSDLLKDTAEAEQKRNDGTTNKSTDNEEAENGNGDTDLKQEKKFVDQSFKVAKTSKHAGEMVSHWVNRALDMGVPKLIEEFRMNLSKWQPEGMTTNAFLANRDKNRYLDVPCQDQRRVILNWPGLPNDYIHANYVANPARDHRFICAQGKFKCSQYWPREKGESMSVGEGEGKITITNLDVRPLSEADSFVRVCRLKLQYSIKGKPITSTVTHYQWENWPDRGVPSTNLTATKLLSAVRGTTKPIIIHCSAGIGRTGTIAAIAYVQEKMQHGQYIYVHRVLLAYFLEKYRDRFSQILEGEGEAKYAKWLEDYKIATGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD86</accession>
    <name>A0A0D8YD86_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MYND finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD86"/>
    <dbReference type="STRING" id="29172.A0A0D8YD86"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052452">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="73"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="394" mass="44021" checksum="50E7F3D7D936B7F9" modified="2015-05-27" version="1">MSSQESLFAAIEAGDINRASCLIESGVDINSHDATGMTPLSAAAYRLVFIGNASLVKQCIDKGADVNDKQHSQGYTPLMFAALAGKPDICKLLMDHGARSYSTNSIGKTASELAAFVGQHECVSVINNHVSIDQIEKFLCPQSATAPDEIHPVAIAFELSNYEEAMKYQKKKLRYALGLTHHLRRKVDKLITNPMFQILYVIDRVFEKQLRCKEGNEVMSLKVWVVLFIMRELYKFIGELVSSGKTSHDACLMYAKFLLKWEPGEQVRKNLETLLRNAVAAFPYHHSLLYETLVKAMSKTAYGDRPTAFEYIVQGLFGHRLLMASKFCATCGACTAKKRCPKCKLCYCSVSCQKFDWSIHKQCCESIKTWNVSASVKDTISLDDIKAHIDEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YG18</accession>
    <name>A0A0D8YG18_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_00044</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19114" checksum="0A280422EA22B53E" modified="2015-05-27" version="1">MEIFFSLFSDGARCFSCMSRLYEVVWPSLSYIYRMPKNFTDDCNDERIANGHVPVVHCDTICVSMYEAPNIAGVRIGGHIRGCMKDVLIKGFNETIVNWYRWMHRDSCRPYRKKELFKLEGELVDESTIDVCTCYADYCNGNSSRIDFLYFCLSFVLFVFLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YG37</accession>
    <name>A0A0D8YG37_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">choline-phosphate cytidylyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
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    <dbReference type="EMBL" id="KN716150">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="reaction ID" value="UER00739"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_trans-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="223" mass="26010" checksum="B385068DC2EE91BA" modified="2015-05-27" version="1">MFYSGPRYQQRQARTMLHTSHKFVPYTLTQLRNGEVPENRPIHIFSEGIYDMFHYGHINQLRQVKEAFPNVKVTVGICSDEMVLKFKGGPLVMSQDERLASVAGCKYVDNVIDHGMFYPTIELLDKLQADLIAHDNIPYLVAGSVDCFKLFKESDRFLPTQKRKIYSQIVNKKLPIRRLIHIEQHPRKYPQNLKTTIKKWKQNGFRELIALYPRMGRNSSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5J8</accession>
    <name>A0A0D8X5J8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14364</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720952">
        <property type="protein sequence ID" value="KJH39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5J8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X650</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X650"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="23540" checksum="C48645DDE4EC6837" modified="2015-05-27" version="1">MQTAILHGSTALLLSSSTLLELQQQAQHRRLKKLTIQPSTLVASATTPYRIFYHSSKYLYFKHLNEQNSRQGGTSSTLILQDNELMIYHNYPHVKLHERNNFKIRKCIVTLGDPNIRKLQSRPMKFVKGSSVAAICVTLRISTTHVGSQRCGAKRIFDVELTLLMGQAVVKTEFSWSYDEEPHASSDVLEKNFWNNVIVFFLSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6M5</accession>
    <name>A0A0D8X6M5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_13893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH40175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14692" checksum="C544C0174AE33E6D" modified="2015-05-27" version="1">MNGREWEESGHFPRVTLCDFEVKVLGNVHRHTVQCVLMINMFNEKIFLFLWQLNFVGKYLTGIEGYKMVDSQSLRRFVFHFLRQDGVFLLRMVATHAGELPCYELAKTLWNNYCDNKEGKMHDI</sequence>
</entry>
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    <accession>A0A0D8X7C9</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722054">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7C9"/>
    <dbReference type="OrthoDB" id="5919351at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7620" checksum="4321DEBC04AFC84D" modified="2015-05-27" version="1" fragment="single">VYQHGTIGAFIRQELEGNRFFTVSIEILSGNRGDEIRTARHGGFSSFIRCVYKAKRVNNNIVTLVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8A7</accession>
    <name>A0A0D8X8A7_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717012">
        <property type="protein sequence ID" value="KJH40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="475" mass="55750" checksum="941667CC08ABD448" modified="2015-05-27" version="1">MVLHGDKIDKFKEFCGVAEDSIALRYLRHCGYNLQAAIQHFYQTNGVLEENEEEEEGWNRDVLGLSASSNSISRNNHIEHNAPPNSQSVLRSITPNSRAVQRWRQFAFAFLTLPFNFFISTVYDVLKFFYELVVGERTPSIEDMRHDVGIFRQSVMEKFSRTSVEFFDGTFDEAYLAACDSDKIFAAFLFTPGARQYEDVVRQILEDDNFNTTVIDFDMVLWGVDPRSAAGRMAARQMKLTKFPSFVALSSRDESTLMRVETPSSAQDIWPLLRQCALEELELREEEEFKKRILRENRMLMYQQEMEYRESEERDRAIMAERRRQKQLQEEENYKKNKEEKERHDAMVYCQQALNELRREMSSNQEVNDYSGKDCIRVLVRYPCGETSKHNFSPDESSKNLFGVVFTESYCPDYFEAHYGFPRTKLNFYSERYHNILMKHRRSLGQQTLSYVEPKTFRQLGISSSLTLYISNIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X964</accession>
    <name>A0A0D8X964_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716904">
        <property type="protein sequence ID" value="KJH41103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X964"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335633" evidence="1">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="239" mass="27173" checksum="5DB53FCFFD9ABF30" modified="2015-05-27" version="1">MKLLILITITLAIAIASYNSKPNRYQPAANPVPYGSPSNTGQYGAIFNTAPYSAPLNYPLSIDQSPFLIPWWHYSSSSSGQRRRSRCRNSKESDRSRRKCSRCFPLTKVVNESANITSINVRYNTLINPCKQAILSCPKSEDYAIVAFYAQNTLNSASLFFYRRGFEFSFEILKDLLKNDFIFNYYCVPCSVKKNFRWRSESLEDTVISIQSVGCVKQATNETSSVDGDDEQLPEDYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X994</accession>
    <name>A0A0D8X994_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716895">
        <property type="protein sequence ID" value="KJH41138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X994"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11120" checksum="4BBCC38F01284AB5" modified="2015-05-27" version="1" fragment="single">MFETNGSIKIILSLTHSLFEEGWKIYFTCVQWHSADAPALRCISGSVLECSPDTRTTTVRPPSANPPYAGDQWLSNATETRVEQDKLSGQCFMMCTALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9N4</accession>
    <name>A0A0D8X9N4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717347">
        <property type="protein sequence ID" value="KJH40339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9N4"/>
    <dbReference type="STRING" id="29172.A0A0D8X9N4"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF172">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335649" evidence="3">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="44320" checksum="CCF53FE874D3BA3C" modified="2015-05-27" version="1">MIWLCSVLIFGASALADDDLSQLVSVIVLFRHGARAPTDRISNASHREFFSNGLGELTNIGIEHSYDLGRFLQKRYVNNGFLRSPLLPSEVYFRSRAINRCLMSASLVGSGMFDVNGTSNRPVVPIYSQEKNDMSRNKSITESILQLLSSRSNCTAEVKVVFNMCGRTFGRSYKNFVEYQGFIFECLGLQNTSEAFHDGKSFEVIDSLITEYQNGLPMSDWFERHKKEIFENFVKVENLITGVAEYHDVSMLRIKSGHLLYTVFEQLKSNWQQFLESNSVKKRKFIAYSTQDWVMYAFLESLGIREFAINDNSLPKYNSLIIIELRKLSDMPVVKVFFRDPTEETLKDVTFAIRGCNSSNHCPLQLLLNCCNSYLTANPLQECYPEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9X2</accession>
    <name>A0A0D8X9X2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716842">
        <property type="protein sequence ID" value="KJH41363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9X2"/>
    <dbReference type="STRING" id="29172.A0A0D8X9X2"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="10601" checksum="F8FEDDDE9AB3E55A" modified="2015-05-27" version="1">MSDLLQAFVGCGIGVPHIGFVCTAFGISDAICSLVFGPLIKLFGRMPLFVFGAVNNMLMIVTLMVWPLNPADKAIFYVAATVWGMADGVWNTQINGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAL6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_13246</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11317" checksum="402085C963FE1F73" modified="2015-05-27" version="1">MLPQIAVMMIFVWDTSRGYTSHIGGSGHRCYSCMSRYYGVTWKFAGYSRIYVEPSAFTDSCRNPSGRGAEVPVSFCDDNANCITMVEDLKIGTYVNMKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBH8</accession>
    <name>A0A0D8XBH8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716730">
        <property type="protein sequence ID" value="KJH41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBH8"/>
    <dbReference type="STRING" id="29172.A0A0D8XBH8"/>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CUT_N"/>
    </dbReference>
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        <property type="entry name" value="Cuticlin"/>
    </dbReference>
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        <property type="entry name" value="ZP_dom"/>
    </dbReference>
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        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF16">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335752" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="190" mass="21985" checksum="082E276473D2B1A2" modified="2015-05-27" version="1">MIIHWLLLTCTFQLTHTIPVPNGQLEKPFCITIIYERYFDEVTPETRKAEVECGESTIEVIFLTEAIFEGRIFVIGHSNDSRCASRNIGRRTTSIIINKDECGVVTTRSVNPPGLFSNVKIMISFHNDFITKVDRIFKSGFVIMTSSLMVHMHSHFEKPLQILKKEYGVKFSLDHFNSSYDNEGFRFRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC11</accession>
    <name>A0A0D8XC11_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716886">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XC11"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11763" checksum="B1703A64E59DF92F" modified="2015-05-27" version="1">MTSSPSSSSLSRSDIDPLPLEGVFGQYRFADVPKLKAIFYAEFDIDIGPVIRYQIPEDQVVVSPERFSAFSAAIIPKDEMLNRLVKLNFRDYKVMGHPIGLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCX4</accession>
    <name>A0A0D8XCX4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716787">
        <property type="protein sequence ID" value="KJH41632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCX4"/>
    <dbReference type="STRING" id="29172.A0A0D8XCX4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF414">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13245" checksum="E1C6757D643B0551" modified="2015-05-27" version="1">MALQTVVNKPLLKIEEVQYGTMILVDELQVSAAYIQFKTDWQMKMLLFDLLFAGVETTATTLKWGFLLVAINSQVQRRVQEELDRECLGDVVTLADRPRLPYTQATINILKSLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDI2</accession>
    <name>A0A0D8XDI2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_11328</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716639">
        <property type="protein sequence ID" value="KJH42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDI2"/>
    <dbReference type="STRING" id="29172.A0A0D8XDI2"/>
    <dbReference type="OrthoDB" id="10063829at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="16" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="19863" checksum="D9625127AA66ABA1" modified="2015-05-27" version="1">MSGRKIAAATVQNRTQTPFWNWLRNKLLAVDRQPITPPPGLPTPDGKAKYHNPLRFPKSQSARPGSAEPPSLPGGVHHLLADNYYYTRDGRHEVLPPKPIYKSDGHHVKYGTYAGEELTVENAVQVNKGPSSNFGLDAPTPGFGYEWKRKRTEELEATKEDAELARLERFDRFTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XET4</accession>
    <name>A0A0D8XET4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716700">
        <property type="protein sequence ID" value="KJH42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XET4"/>
    <dbReference type="STRING" id="29172.A0A0D8XET4"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF62">
        <property type="entry name" value="SMAD PROTEIN DAF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
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    </dbReference>
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    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
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        </location>
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            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
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        </location>
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            <end position="278"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="55533" checksum="B737685831A9B319" modified="2015-05-27" version="1">MSAKNETYMSLSKVFLLKQFEKHTDIEFSRKAIVTLLKKLASKESEVDSFIACCGSQGRESNTCVTITRPLNGRIQITGRNLFPHVVYVLVFRWSDTQSHQLTSLNICKYPHSRRCNVVCVNPYHYDRFWYRNDRDLVSPYRMLSQHGQNALPTNRTSSHPNANQHVGSGRESPPNRADNSVAVAPVDQQEVDTMSLRAPSAFDMSSHLVNQIRMLGQLKMDVASCIAENTKVMSWLNDYVVHPALTANNAREQPWTGPQLESSNSQLMQPNEMSSSSNLSIANTVHTQQNNSASTSSGRIIQSQFPAIRIANVELQLNTSNIFGYEIHEFAVRRDLTCFVSEPPSCRGTSNWGSLVYHEQAAQIGIFQAYESNTFIDGGYECEANKFGLGAVNNPRRERRCVAVRGTIGNGFRLSLKENGDLWIEVYTIQPLFVHGYYLDQQRGEVVNRIYKLYHGVREKIFDFNTSKALLQRHIIPCKYAKAFLSGEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG44</accession>
    <name>A0A0D8XG44_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="20912" checksum="5DE36B2F08045F57" modified="2015-05-27" version="1">MGVKDSQKESPRKKSATGKQKHFKSPLNRDQRKKNESKNIAKRLEDNVKNLKNKYLSGNKSGNANNEEEERRKNHVYQVEQPRRNVPLAQKAEKDMKLQFGVCAKEDTIGTALSINLPSACPQKTANFSDVHYESSVTGNTTTTTGLISVNNVQRERTLQNTSVTGTTLTADVVPAVPLRSPKYGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG67</accession>
    <name>A0A0D8XG67_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_11321</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716638">
        <property type="protein sequence ID" value="KJH42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XG67"/>
    <dbReference type="OrthoDB" id="10408821at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <end position="75"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
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            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="294" mass="33008" checksum="6D954BBA81867F2A" modified="2015-05-27" version="1">MDQLITSKKSETQQNNRDGSFMVTSKTSKQKGGEPQRAAEMSQKKADSWMPPHSSHLKSRSLTPTSTGSLTTQNGIHHNEDHLAIQKTSKCWLTPTTVANSCSNSKSGIIEPNGTSHQHFSHRTSEDGSLSDPAPVPSPFWMATNPHSSYTSAMMSPIMNEMLSTDEGTDDERSRLIRDRLPMASQLLSRLPHQQRVPRFRISMSPPNKKKIFLTDSHGVIYIHMRIIDTPLDDDSDSMNRRFEMRVSSTSKNEVDNRTPAENGRGRTRSPQHCDSISSSQRKDLNRTNTSNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGD1</accession>
    <name>A0A0D8XGD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_12588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716825">
        <property type="protein sequence ID" value="KJH41436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGD1"/>
    <dbReference type="STRING" id="29172.A0A0D8XGD1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="277"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="464" mass="52339" checksum="7EA813744585FC5E" modified="2015-05-27" version="1">MSDSSTSEDEQLANADHIENLPTSTKTHEESRITSEASNNVEEQKDPTSFSELLVLKGVCEPLCEACERVNWGRPTKIQMAALPHALKGRDIIGLAETGSGKTGAFALPILQSLLELPQKLFALVLTPTRELAFQIGQQFEALGAGIGLVVAVIVGGIDMTTQALALAKRPHIIVATPGRLVDHLENTKGFNLRAIKFLVMDEADRILNMDFEMELDKILRVIPKERRTYLFSATMTKKVAKLERASLRNPVRVEVSTRYQTVEKLKQHYIFIPFKYKEAYLVYILNELAGNTFIVFCATCNSAMQIAVLLRQLGMQAVPLHGQMGQDKRLGALNRFISKQRNILVCTDVASRAQKVLIFLMLIWLSITMYHLIQRIIYIEQVGRTARAGRAGLAITFVTQYDVEAYQKIEAHLGKKLTEYPCVEKDVMLLVERTQEANELAVKELKEMAERKKKKKRYVLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGH4</accession>
    <name>A0A0D8XGH4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716622">
        <property type="protein sequence ID" value="KJH42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGH4"/>
    <dbReference type="STRING" id="29172.A0A0D8XGH4"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="11209" checksum="65052E344035FE88" modified="2015-05-27" version="1">MKHKIFSYCATQGYRPYMEDRMHYMYDPNNNLSIFGIFDGHGGLYVSDFLESNFAKSIRERLLRLGSKRKISLEGMLDVTVKEVRKNIKIFSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGM5</accession>
    <name>A0A0D8XGM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716807">
        <property type="protein sequence ID" value="KJH41526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGM5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10516" checksum="17E60CABC73EEC7F" modified="2015-05-27" version="1">MSDNIRSNINSILSGCDGQHVAALIDELVEICNVYRRSINGVCHGLTQARSNDDCQSGDDSYMEERVEELIRRHGNAVLELMSLYNNPQQPQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGT6</accession>
    <name>A0A0D8XGT6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_10175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN716525">
        <property type="protein sequence ID" value="KJH43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGT6"/>
    <dbReference type="STRING" id="29172.A0A0D8XGT6"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="348" mass="40689" checksum="1B11D40B07453A28" modified="2015-05-27" version="1">MFWRTLASYVLLKRHRPSPSPLKLIVLLFIWILPYLLLANYLERSLLPFRLLCYTQSDLLSSEPLRNETPECIRQYFPNRTPDPECTLTALPRILQRPQIPMQPRRILFVRTAPHSIDYRNFIRDTWKTQTESFAVVIFVCATGANITSEAMKYRGNPIPLKIQAEYLNRIIDILHFDFIDSYHNLSLKMMAIYGFVLQEIPSVKEIIITNDDTIVNATALIQLLNVERTGSWMLGKVSRGYPRLFMTWLPWHVPGEMYPNLCYPRFTQGSSFILSRDAARVLLENICQIPFVHLDDVMMGIVASCTRLKLLHHNGFDKHTLANFVVYHYQYTRHSALHLRQLWSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHF0</accession>
    <name>A0A0D8XHF0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716586">
        <property type="protein sequence ID" value="KJH43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHF0"/>
    <dbReference type="OrthoDB" id="5875837at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="38088" checksum="7B81B77D592EDA01" modified="2015-05-27" version="1">MVDDKVNMALDDIIKLNKRKRAGKVNRRNTESIRQAKERKKISSRGRGGLSRRRGGLVNLGQRRSARTRIIRRRSVSSPSTNVSVNDAATRRLVKNLVNKALRRIRAASSTSVLNRGAVYTNDPLRGISARSRGIRKRVVEIPSVVVRRPRRVRTAGRTQIEEEPDRFMYQTVRVVKREPASVQVVRQRQERLPYHDVNHRDAVRIVQNQRASVMPTSHFIQQRLPQFSQQRSRVVAHQPARIGKALITRRSYPSIIRRGNPRGSVIYVNEQMSSRVQPARSGIRFIRRNPNRQFVAYHDEFDRYPSSSTANGNRGRKRKGRGFDVAYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHI2</accession>
    <name>A0A0D8XHI2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_10793</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716583">
        <property type="protein sequence ID" value="KJH43194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHI2"/>
    <dbReference type="STRING" id="29172.A0A0D8XHI2"/>
    <dbReference type="OrthoDB" id="6073114at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="45248" checksum="4E6817F7F863E77B" modified="2015-05-27" version="1">MREIVHIQVGQCGNQIGSKFWEVISDEHGIDPNGHYVGDSDLQLERISVYYNEAGQNRYVPRAILVDLEPGTMDSARAGPFGQLFRPDNYVFGQSGAGNNWAKGHYTEGAELVDNVLDVIRKEAEGCDCLQGFQMTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRSNQQYRVVSVPELTQQCFDAKNMMAACDPRHGRYLTAAAIFRGRMSMKEVDEQMLNIQNKNASYFVDWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTGKRFFKRFLFEQNRTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHN3</accession>
    <name>A0A0D8XHN3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716577">
        <property type="protein sequence ID" value="KJH43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHN3"/>
    <dbReference type="STRING" id="29172.A0A0D8XHN3"/>
    <dbReference type="OrthoDB" id="5918422at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="13"/>
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        </location>
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            <begin position="1"/>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16211"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="127" mass="13441" checksum="087864D8D59A324E" modified="2015-05-27" version="1">MSGRGKGGKAKTGGKSKSRSSRAGLQFPVGRLHRMLRKGNYAGRIGGGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRINPRHLQLAVRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTAGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIC1</accession>
    <name>A0A0D8XIC1_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">Fibronectin type III domain protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">DICVIV_11939</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIT3</accession>
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        <submittedName>
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        <lineage>
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    <reference evidence="1 2" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5855500at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="169" mass="19409" checksum="AC192C426633B21D" modified="2015-05-27" version="1">MTSSEFAGGPTQGLSGLSAFYYDPSQTQQQSTNAAAYFPQTTALATNGSFANQTATTHHDPIKCASYFYCHFVYYTLYRKESTIFILYRFQNRLPHRTFSVIYEKSKLFNKIISVLLQNLCYPQRSVDWTKDDKEEKKDGDEEKPSVAAVYPWVTRVHSSSGEGFFFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJJ4</accession>
    <name>A0A0D8XJJ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716453">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005501">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002449">
        <property type="entry name" value="Retinol-bd/Purpurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873:SF0">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="566" mass="64681" checksum="23CF56F98B03B2FD" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJJ6</accession>
    <name>A0A0D8XJJ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isocitrate dehydrogenase (NAD(+))</fullName>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NAD(+)-specific ICDH subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="2"/>
    <dbReference type="EMBL" id="KN716515">
        <property type="protein sequence ID" value="KJH43927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJJ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XJJ6"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="385" mass="42465" checksum="103E687E6363E1AC" modified="2015-05-27" version="1">MLAKCFKKINSLTQVGTRVLSTEVRRVVLIPGDGIGPEISKSVQDIFEAAKTPIEWDPVDVTPVKGRDGVFRIPSRCIELMHTNKVGLKGPLETPIGKGHRSLNLAVRKEFNLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITQDASHRVAKYAFEYARKNSRKCVTAVHKANIMRMSDGLFLKICREEAALYPDIKFKAGLFFFPSFLFHATEYFFRFVKYDVLVMPNLYGDILSDLCAGLVGGLGVTPSGNIGEDAAVFEWQSLGGHRDTDTVWFQIDTVARSVHGTAPDIAGQDKANPTALLLSAVMMLRYMNLTSYASKIERAVFDAISEGKAKTGDLGGTGTCSSFTADVCARIRNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK80</accession>
    <name>A0A0D8XK80_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_08944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716433">
        <property type="protein sequence ID" value="KJH45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK80"/>
    <dbReference type="OrthoDB" id="5870103at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="908" mass="102975" checksum="6738BD14DBF889A7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKA5</accession>
    <name>A0A0D8XKA5_DICVI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716434">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKA5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13422" checksum="D3C481382E92267B" modified="2015-05-27" version="1">MATDNTMEDNLNENDAMEDELHGAYILSDFDIEMGTSQTALMYNSEKDSRSTTIISLRKSLQSTLRSPCNWLRMVITTPIRFLVTKFKLLIIILCYSLFGAWMFMTLESEGLSKMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKD4</accession>
    <name>A0A0D8XKD4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716485">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="458" mass="50199" checksum="611DDC482B0889F6" modified="2015-05-27" version="1">MEKSFTNPETSTSSSSNGPLQSFLQHAMSAIIAIFFALRIFIFSSSERDLEASGEEESPPLILNQMGPSSVVSLLSTDDLPISSSQEQDNQPPPPPPLPMLLQQSALPPFLDTINEEESDDLRSLSSASFASPKTIFNRSLSSERIDSFCSSSSVLSDSEYFSPVAKSPQHFKHVPSESKGNAAVTSTYVLKPFTVSREETNGLLKELARLGQDIQTRSINGAEVRTPNSGKRSIISRVAREMSHKLDIPMMDEQVDTDRDQEEELVYSEQQVKSSNMDDNLSLNSVSINLNSTKDNLLDLSITSNPTIDEKSAMENTILRDVVRPSVRPPSPPHDLPPPPPDLASPVQASTPSSSLRTTESQYHFSSNDNGKVFVQTQHLNHAADTPQLAQSKVVSPSTLFASVMNASGRTFASSYDRSGACSFFYYTVFLIEINIITRILATKLIQSKSRDISKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKL4</accession>
    <name>A0A0D8XKL4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase</fullName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
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    </evidence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL57</accession>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Tango11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716418">
        <property type="protein sequence ID" value="KJH45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL57"/>
    <dbReference type="STRING" id="29172.A0A0D8XL57"/>
    <dbReference type="OrthoDB" id="5986838at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039433">
        <property type="entry name" value="Mff-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008518">
        <property type="entry name" value="Mff/Tango-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501:SF6">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05644">
        <property type="entry name" value="Miff"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mff-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="16161" checksum="B0A39BA43BDA0CC8" modified="2015-05-27" version="1">MIVPEHISVRGEPLENVGIDDQNVSAHDRLSKIMNVPDRIVLTGNNTYKGFVADPPELMHNSVAGKYESNIQDLPSTITLENNPYLDRSEPADEPVQSENSIAVEENPLQELKLMRRQIGRISTRLFQLEDDLEKHRFREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLM2</accession>
    <name>A0A0D8XLM2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09309</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="KN716457">
        <property type="protein sequence ID" value="KJH44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLM2"/>
    <dbReference type="STRING" id="29172.A0A0D8XLM2"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="374"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="817" mass="92137" checksum="7BE7C78ADE8C1CBE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLT0</accession>
    <name>A0A0D8XLT0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716404">
        <property type="protein sequence ID" value="KJH45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLT0"/>
    <dbReference type="STRING" id="29172.A0A0D8XLT0"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13406" checksum="462AAA308267F802" modified="2015-05-27" version="1">MFRGTVRYCSLNVHQYKEQGRHDDLYGALFSMIECLTASLPWKGMVRKEAGKVKENTTDAALCKGCPPSFLEIAKTLRKLTYQDVPPYKTFMEKLKHDLPAKLKMYVECVIMYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLX8</accession>
    <name>A0A0D8XLX8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10607</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716565">
        <property type="protein sequence ID" value="KJH43381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLX8"/>
    <dbReference type="STRING" id="29172.A0A0D8XLX8"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000038">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="616"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="763"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="879" mass="97724" checksum="93FE044846826D2D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM85</accession>
    <name>A0A0D8XM85_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716390">
        <property type="protein sequence ID" value="KJH45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM85"/>
    <dbReference type="STRING" id="29172.A0A0D8XM85"/>
    <dbReference type="OrthoDB" id="5875171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF194">
        <property type="entry name" value="CUTICLE COLLAGEN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0176">Collagen</keyword>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="29070" checksum="7B5E0052C8D1D073" modified="2015-05-27" version="1">MFEEKFVVGVASACSTLTIVTCLMVVSSLYNTINGIHDDVFDGVSVFRAETDSAWTQMMTYQIDVSPASKPRENAFNSIFRRKRQANGLPAFCQCEPSKPACPPGPPGPPGQAGTPGQPGSPGEPGEDSSVTYAPIDCPNQNDGCIKCPPGPPGPAGPDGAPGNPGPDGNPGLPGLAGQGGQPGPPGPAGDAGAAGNIGPDGQPGQPGEDGTSGKGAPGSPGQAGPAGAPGNAGSPGQAGQQGEIGQPGPSGQPGAPGLPGIDGPLGEPGTPGLPGSDAAYCPCPPRSNVYISRFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMQ5</accession>
    <name>A0A0D8XMQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DICVIV_08869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716428">
        <property type="protein sequence ID" value="KJH45084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMQ5"/>
    <dbReference type="OrthoDB" id="10588535at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="18041" checksum="82EDEA114BCF5A07" modified="2015-05-27" version="1">MKKCRNAISLKTGERVVLKTGLYAAQYRTKLELWRGFLPYQSCYHYDVELQLITGDNVTSRSDTVCIGPGSESAEQVKFWLFTIIMCMLVFHVFVIPITNEILKDDYAGDDEKPIAVMSTHGRLSKHETTHNTITDRTKIIDTTSSTSTSNDKRKGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMT2</accession>
    <name>A0A0D8XMT2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMT2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMT2"/>
    <dbReference type="OrthoDB" id="5863196at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF357">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="30206" checksum="67B7EB1C60F2AFA1" modified="2015-05-27" version="1">MTRLPRLHVSCSSCRPATMDEKLKFVQARKLKHIVFFGVAVSTIATMTSILAVPMLCVYMQNVHSGIQEELTYCRVRNNGLHSEFVKLEKARYKRQSSGSCCSCGVGLQGPIGLPGSDGEPGSDGKPGVPGPPGADADDVNSVPTAQDFCFECKPSAPGIPGMMGFKGPVGPPGEMGEQGSMGLPGPRGPPGPRGMPGREGDVGPDGKPGQPGAVRMLKSPVGETGPPGLQGSPGPDGMAGSPGQSGQPGQQGPDGDPGQDGTPGKDGEEGAPGSPGKDGMIGSCDHCPVPRTPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN12</accession>
    <name>A0A0D8XN12_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase family M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716424">
        <property type="protein sequence ID" value="KJH45142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN12"/>
    <dbReference type="STRING" id="29172.A0A0D8XN12"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="362"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="593" mass="67552" checksum="CB4973713373E8D2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNK1</accession>
    <name>A0A0D8XNK1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="KN716368">
        <property type="protein sequence ID" value="KJH46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="7">
        <location>
            <begin position="167"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="382" mass="45071" checksum="16362422AF9A6659" modified="2015-05-27" version="1">MQQRQKEEVVLCGDLLVTSFGLQRQQEREELDVEMLTFEKFIRLYNKICPRSEVQELFVKLWVFVLNLFNFSFFLNFRIAELFRSGQKEYLTRERLTNFLNEEQRDPRLNEILFPFFDNTRTQVLISKYEQDNNYIDNGKMSGDAFLRFLMSDENSPVFLDRIDMYQNMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLYQIRDTAFERSEFPVILSFENHCSKSNQLKMAKYCMEIFGEMLLAKPLDDFPLDPGVPLPSPNRLRRKILIKNKRLKQEIERHQLEQFLREGKLDEEDEIIETPEVVGEDSVSPRKYSDYFSNQTHKGILPLVMDVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPJ5</accession>
    <name>A0A0D8XPJ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716485">
        <property type="protein sequence ID" value="KJH44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XPJ5"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19424" checksum="AC0A05B23A7B2566" modified="2015-05-27" version="1">MSTVACEEPFAVAIESPLLQSVCHACFRVATLKELMCCSRCSTIYYCSTTCQKHDWSNHSVECKFLVNCSSRVPNGFVRLMARFYLKVLAQGESVVSFNSRTCKDLVDNCTELLKPAKHTENFSLVFNILTTYMHGVDVQSIKTELFSAYGKLVSNAFSITDATGRLLGTGLYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPQ9</accession>
    <name>A0A0D8XPQ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
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    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
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        <property type="entry name" value="TAF7"/>
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        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
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        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="4">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
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        <source>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="103"/>
            <end position="118"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="148" mass="16177" checksum="12C478947A1D6771" modified="2015-05-27" version="1">MLFATGLRKAIDQADPSMAAIMVTAEQTERLLTEKRRRQMIRRHTCSTLKPDVKDLGPVTFFTPSSANEEDKYEPLPPPAAPLSRSPADDWGAGFPLPAAVPTPQSIASATTNAQVAPSSFGGDDFDDEWTDDEDEVLVRCTSYSDFL</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="124" mass="13968" checksum="20995F864FF770AA" modified="2015-05-27" version="1">MRHAISSARNCKAFGPGMIRSDNILTEPFTATLKNTVGNLEWDDMEHGNLLVLDYSTGKLWILLSGVKGVRRLKEVRLENPLNSQEALGISATRARKNVSKAEKTAFKNESKDEKKKLTERKRV</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="3">HannoverDv2000</strain>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH46877.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30197" checksum="EF76B14905E46828" modified="2015-05-27" version="1">MSRIGDPSYHKLITSPIASLNSLMIQTCSPSIPSTASTSQIPITDLTSSLACSLLTCSIPTATMISPPPPYHAINHHHPHNYHQQLFDIHSKAKIGEFDVDVIGLSQSTKEVSIYDHEVDTDQEDKPLDLSMKNSTSLYSPTTSRPSVIIESPSGRNPSVRRSASSVSSSREHDVHEHFRRSLSGKWPRRSKIDDEKLSIISDVLYPKKNSITGNEKEMQFNKQQNYHHSNSVNINNCDNRYYAKKIVYEIKFDIVERRPLFHLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT54</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">HannoverDv2000</strain>
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    </reference>
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        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="EMBL" id="KN716327">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19 20">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
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    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
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    <dbReference type="EMBL" id="KN716309">
        <property type="protein sequence ID" value="KJH47404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="60033at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein kinase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate cyclase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
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        <property type="entry name" value="HNOB_dom_associated"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="244"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="49922" checksum="20E40CAB8F30E669" modified="2015-05-27" version="1">MDIVFMESMLIDLATGLSFIHDSFIKKHGRLTSLVCVVDDRWQVKISYYGLTYLKETESRSNNELLFIAPEILRGEAEPMGTQEGDVYSFAIIASELITKKIAWDLQNRDETAEEIVRLVAQPSKHPFRPVVEPDQNIEVSERLVDLIHECWSENPNHRPTMRKVKEILISNGRGRRRNLMDHVMKTLERYASSLESEIEDRMLELKEEKKKSDILLYRMLPRQVAERLKMGQNVEPESYESVTVFFSDVVGFTTIASKGTPLQVVTLLNDLYTFFDNTIADHDVYKVETIGDGYLCVSGLPNRNGLEHIKEICDLSLELITGLRNFHVPYIPSENVNIRVGIHSGPVVAGVVGLTMPRYGLFGDTVNTASRMESNGKPASIQMSTEAHQLLCSHHAGYLTECRGEIIIKGKGVMQTYWLLGRQDGLNIRGTLKTDVMSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVK3</accession>
    <name>A0A0D8XVK3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVK3"/>
    <dbReference type="STRING" id="29172.A0A0D8XVK3"/>
    <dbReference type="OrthoDB" id="6022652at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="209"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="816" mass="91733" checksum="3DF99845AA6C3E38" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVL2</accession>
    <name>A0A0D8XVL2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVL2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVL2"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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            <end position="103"/>
        </location>
    </feature>
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            <begin position="149"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="284" mass="31866" checksum="E1B6F6D492B6E200" modified="2015-05-27" version="1">MPSLDDLFTSIDDLRLNEPSYFASDPIVNMNTAAAFSQKTPVMALDEGCRRVYGVAPDYQLIREVPNFGFSCHLMDKFVKGYAKTKKAAKHIAARAMLHEIIEKDRQSDFGIPGLTKEDAHRAVDGLVISDVRIEMSEEDPIHGGQNENYSGKLLQLCQKNKFDTPQYSYKEEGPPNDRTFTTMCKVVDQVVEGVAKTKKASKNIASQKMLAIITKGIDDMNKEFELDREADDDVDSLVDNVPCDVTPSCDAIRMVSDILSDTKRFESPTQEYRILEKKSTFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW05</accession>
    <name>A0A0D8XW05_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_05894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716284">
        <property type="protein sequence ID" value="KJH48002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XW05"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
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    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDLR-related"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
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    </dbReference>
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        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH48002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="623" mass="69954" checksum="6FB5969B1030AC47" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW23</accession>
    <name>A0A0D8XW23_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716285">
        <property type="protein sequence ID" value="KJH47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW23"/>
    <dbReference type="STRING" id="29172.A0A0D8XW23"/>
    <dbReference type="OrthoDB" id="5847988at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="24329" checksum="7D86C47BE190A661" modified="2015-05-27" version="1">MSLKEFTGLDNTKEEVSNLPTATWKSFTSPSSLINSFSARRRSVLSSDVPSSPSKKLAPPQEECIDISTAIKRISALRIRLDEIRTVEKLSTASSSFVAASSSQDRRQQLLEESKRIVNAAKDFASISCSSSDAKWNATVAEIVDCADCLTSAALAVLSESNVYYSQLITTELIQTLTAIHSSLNDAQQSRLNNDDNLMSKSMVNLQSAVNQLMYAITSSSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWB0</accession>
    <name>A0A0D8XWB0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWB0"/>
    <dbReference type="STRING" id="29172.A0A0D8XWB0"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37534" checksum="CBC30B56C773ADC4" modified="2015-05-27" version="1">MYDEPSIPFLVLDIKYCFLQIWCHYRVDYESTPFSNSVSADVLAIHFRGTAADGSYGFIAEISAIPSTADSTNADTVIIRGSRIDRNERGAVLYQNVGEMSPAVVIEDCSLSTNGIHLFGNISTSYHAVQLHLHNTMLVLLRGNSLTYNRGGLVISARSSSTIGRLNAVIKHNLFSWNSNNTVVELYGNNFQMVTMLNNIISYNYVLYRDIMKIDGMSVNLTGNVFFSNTGQHTVDSQGGNYCIPGIPDSPQTYKPFYTTVLKKMLLSATAISIWSSLVFFPKFNTTSLSADQEDKLVVSICFIVLEVITQEGVSFDWWAHVDTNSERYRSTILGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWJ2</accession>
    <name>A0A0D8XWJ2_DICVI</name>
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        <name evidence="3" type="ORF">DICVIV_07225</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716339">
        <property type="protein sequence ID" value="KJH46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWJ2"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="319" mass="35799" checksum="D41ECEADBB82DCD4" modified="2015-05-27" version="1">MGVDISLMVVISTLITSYALIHKRCAWMSDDSDEFKIQEFIAKEENVSCIVRFRNVCTKPRRTLSYKRREDHADESLSASCEVDGDEVVCYCHESLCNVNGNKEFQEAITVKPLSNSTLQSCLIAHLTHGVIPGGENQTSESRLTREGNVLLSATHSTTDTPGIRGTSIAGTRGSNGANDIPGTPSAPDQMLPDYSNYSRNGTDISDNKTSLRKKFIIMIYRLFGIPPLNTITNMNRNTDELSEPIKIRRSFFVVIAVGIIVLSAMIVLMTFYFVLKRLKQEDIEDEAISEAERRIWQDISNRSISNSFKPLRYSRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWV2</accession>
    <name>A0A0D8XWV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_07101</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716333">
        <property type="protein sequence ID" value="KJH46826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWV2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="158" mass="17988" checksum="79C541F8A7DD3FE5" modified="2015-05-27" version="1">MECVTESFCYAINPHIELSEEWCHKPRVGDIKQPDLRAEMQALILTKRGDEISRLFCLRTLLHLAAKHVRTRRVAIPKSVIKPISKETYDNHCIYLCKRLSRSVLKICITTRLKTGSPQKSFCSTPKNKAPYSMRCLHDVGGALVDEKLIPTVEALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX16</accession>
    <name>A0A0D8XX16_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05533</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716270">
        <property type="protein sequence ID" value="KJH48357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX16"/>
    <dbReference type="STRING" id="29172.A0A0D8XX16"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
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    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053302">
        <property type="entry name" value="CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47159">
        <property type="entry name" value="PROTEIN CBG07705-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="11813" checksum="42578FC19DA09C7A" modified="2015-05-27" version="1">MHSKQIIVINAPKFINLLYHTCIPFIPSDYKKKITISSGDARETLLEHIDECCLPLELGGSCDMKSSGEYEIYLPIQQPLYPYPKSLPIDLTLEELTIPAGNAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXD8</accession>
    <name>A0A0D8XXD8_DICVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716266">
        <property type="protein sequence ID" value="KJH48487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXD8"/>
    <dbReference type="STRING" id="29172.A0A0D8XXD8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13725" checksum="04607E322B0ED69F" modified="2015-05-27" version="1">MFVVRCEQSMPIFLFDSGANDVCERHSLQMKSTKRSLPLCSTGIRIIQFKGEVLLVMLSDVQIVVYANELSRCCSGGARHFVQTQTCSNIKSEGSTMTCLSNLDVRTQWCFSVTLAMLHPQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXU8</accession>
    <name>A0A0D8XXU8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716262">
        <property type="protein sequence ID" value="KJH48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXU8"/>
    <dbReference type="STRING" id="29172.A0A0D8XXU8"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
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            <begin position="1"/>
            <end position="143"/>
        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="21668" checksum="70F0E426612CA36F" modified="2015-05-27" version="1">MRDKIMSESWCGRQPVTFTLHSQMNSLDQQKVFDSVGPGERKVILSTNIAEASLTIDDVVFVIDCGKVKEKTYDHTSRISQLKVTWIAKSNAEQRAGRAGRCREGFCFRLYSVEDYDAMLATQMAEMQRTAIHDVCLHAKMFAPENMTVKQFLQMAPEPPLADSVDKSMAFLEVRLIFPSLFCSTFSLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYX6</accession>
    <name>A0A0D8XYX6_DICVI</name>
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            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
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    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <dbReference type="EMBL" id="KN716222">
        <property type="protein sequence ID" value="KJH49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XYX6"/>
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    </dbReference>
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        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="143"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16494" checksum="E691FE21739B460C" modified="2015-05-27" version="1">MCCSQTAVYWYFISHNVKSTFYFSTIGFGDIVPGQALDEGSQEKLIVCALYLLFGMALIAMCFKLMQDDVVQKARWLGQKIGILVHEDFSDSESDLEDDIIEEDDEDMSERTDQDKRSNSSGSLKRDDDLLRGSSYRRHHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ26</accession>
    <name>A0A0D8XZ26_DICVI</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716248">
        <property type="protein sequence ID" value="KJH49019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5868703at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="21120" checksum="75F724C99A029F11" modified="2015-05-27" version="1">MVNETGFSFEIPWESHNVNQDDVYINENVFDWSNEIFPDEESASVGEKRPLDILDDFSLKPKRKAVLKESDAHMEQTDDQSLFTAPIQLRSCLKPVKPLLTDFDENICAVNERILWHKKFESHSAKKKRVRFRVSSVRNRTAPGQDRIKTRTSEESTASYYKNAGSTLHTLPVRLQSSKSMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ46</accession>
    <name>A0A0D8XZ46_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716225">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336065" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12134" checksum="DBD33F3046A38805" modified="2015-05-27" version="1">MLMLFVNLFLHSIFLLVTCSSSLSMDRPTPLDLDCKQKTVQLAEVDRKNRIKRSKRLKKLKKSRKQKLSRKPTAVNREIQWRAANDLETVKDMTSCWGSVQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZW5</accession>
    <name>A0A0D8XZW5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    <sequence length="115" mass="13086" checksum="155C463E3B3219C9" modified="2015-05-27" version="1">MKRATPSTNLSKERCIALNEQGPVVHYLTHHGVTTPNKETTQLRMVFDASADQKNQQSLNEVLYQGPIFLPQIGVILFPFWKGQTTIISDAEKTVLQIDYMREAEMQHAFCGYET</sequence>
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            </authorList>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="MMS19_C"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 C-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="486" mass="54520" checksum="54C037CBEDBDC56E" modified="2015-05-27" version="1">MADSVLRALAAITRSLNENDKSSLLKLGSQLLENLEPFVLQAEMGLTERALNLLLCASSAGPAIRSMIYDRVVPWILMLVQGDVVNVRMNRPEIVQEGLRHITTWLNVIHDHTCDDILLRFQSSIFASLDAARETVPSEALAALYECLAMTSFSGDMISAFSETLQSLSLLLNEENRRLLLEKVNSYITSSVMMDMFVLLLIHSQDPSLMLNYAKLPLCGEQSAYRLCVGVANHEQDLQKVLSLKNQLSHYEVRCAISKGLLLCGKKEGIEIFEELLINVSHNSTNRDVLLNQLCDLFDFDSVASNPHRCLFNVTFLWKQRVFNQLSKSYINIVNQTDETARSVLMTLLPSILKYSENNTSVQQLFEFLPVFRAALTCDKETNSLVLLALPRFIAGLPTDGISLEDVFCVISALSKTLMADDKPMSVILSCLESLELLSRKIRRNFSDANISMVTSATVHALAHHKRVVRQKAAVVRNLWEAKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y292</accession>
    <name>A0A0D8Y292_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Morc S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y292"/>
    <dbReference type="STRING" id="29172.A0A0D8Y292"/>
    <dbReference type="OrthoDB" id="1885370at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF3">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Morc S5" evidence="5">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="26543" checksum="EEB9EF355FE7F4EB" modified="2015-05-27" version="1">MEPGMIGQYGNGLKSRRVIVSHFLHICASFSGAMRIAKDFIMFTKKDGLLTCLLLSRTFHEMYSLKDVCIFLFYYVVFVPVASFTLEGGSRAMYCDSHTQSKMDALFDQFERISGPSGTLIVLFNLRRIETGDFELNFDTPHDVRLSNFEEQREEERNSLRAYLSVLYLNPRMKVYLRGKKVLTTRILSTLLYPYKYNYTAKNLKTCAIKEYERCEQKVRESQSLNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3A2</accession>
    <name>A0A0D8Y3A2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase family M49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3A2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3A2"/>
    <dbReference type="MEROPS" id="M49.001"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="283" mass="32558" checksum="420B27C3248E002D" modified="2015-05-27" version="1">MSRICNSLKLASESAANDTQKKMISKYIEHFTEGDIKFHKGTTASNQNVFAQVLKENKAQEGSRLWIKDVEPVIESYIGFIENYRDPAGTRSEFEGWYSLIHICSNFDRRYDDIRQNEGFKNVSLGNVIAATPKQKMNFISQEDEVWFVSIIRFYYIAVFIKDLLHQYHKDSFEVQVGLHELLGHGSGKLFQKSRDGTFNFDKNTKDLITGQPVECRAEAVGYVLCCDADILEIFGFKGEVAEKVKYVNWLNEIRAGLLALEFYSPEAKKWGQVCIMQSNDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3E7</accession>
    <name>A0A0D8Y3E7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3E7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3E7"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000384">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF399">
        <property type="entry name" value="BLOWN FUSE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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    </evidence>
    <sequence length="144" mass="16898" checksum="7131E7E8FC1B70F0" modified="2015-05-27" version="1">MVNRLSSEYENVVLITRSFLANKLKSVRWRGRVHIFSCSTLSEDDLLVLLAAIEWGSNAYVLSNDRFEVHFDRSNTTEQYYVREWMRRRILRFNRSDFSYDCLLEYGEFVQQLTTSTFFVPISEETSGIPLRSAFLVSKDSLNS</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
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    </reference>
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    <dbReference type="STRING" id="29172.A0A0D8Y4N0"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047777">
        <property type="term" value="F:(S)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106064">
        <property type="term" value="P:regulation of cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="573"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="808" mass="89616" checksum="7ADEA7E8532C68BE" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4N8</accession>
    <name>A0A0D8Y4N8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_02622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4N8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4N8"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="13593" checksum="7BE41C485B774DCF" modified="2015-05-27" version="1">MKLFRVKKRFLDTLYVDEKLAMKYLYEHRVIHRDLAARNVLVKRHNHVEVTDFGLAKLLDYGQEKVKVMEGKVAIKWLALESLKDQSYTYRTDVWAFGVTCWEILTFGQVNKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4R6</accession>
    <name>A0A0D8Y4R6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELP1 first N-terminal beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4R6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4R6"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="1">
        <location>
            <begin position="53"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="48980" checksum="5669ED0C40E8FA24" modified="2015-05-27" version="1">MKNIVLTKALSSSCNAQLLKGCSLFVEDSSTHIVYFVNLEGIIVLDENFKTKTVIPCRDQFDYFDPVSIDLLQDRNEVCIILKNAQVITMDVESYAICTVGFLGETCLATAWSPDETILTVSEDDRVVFYDGSFEIINYWNLSNSDTGKESLVAVGWGSAETQFQGSAGKAVRKPVEVSRSAYPEDSHNSYIRWRADGSVVTVSFHERESDERRIAVFNRDGELMARLKNYESLEEIFSIRPSGNCIATTTRSSDGARMLVFYEKNGEKRREMLLSPMADQSKIINMQWDVEASCLCVHVQYNDKEELELWTESNYDWKRQWTASFKGALNWKWDTEKARRMCVLLNDGVYIRLYFSRLLGLVGSTALVVGTGTLHLTDFERCPVPPPLYEYALTIKGAAHSYAFDDSRLAVIDSDMTLHIARHLFYTKQQ</sequence>
</entry>
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    <accession>A0A0D8Y4R7</accession>
    <name>A0A0D8Y4R7_DICVI</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4R7"/>
    <dbReference type="OrthoDB" id="5800929at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16486" checksum="C99530FCA039FB82" modified="2015-05-27" version="1">MRGTSPQGDLPFISKFIASLKSLKPEIVDESGLLSPSYRKKNTYIPPLRFVLFEWFLHEKLPYQAQLVIHNITCEDPERGVLAEIDSVNVRGQLNVVDETEPVSSGDGENHDEKLFEQLPSLRIAREYLRRKIAAERELEHQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4V2</accession>
    <name>A0A0D8Y4V2_DICVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716229">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4V2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4V2"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16429" checksum="D2A5391E3C25A16D" modified="2015-05-27" version="1">MDPVEVGEWLGGRPQQLIFLTGLDPNNKESHSALVNTLGARCSDRIPLNFRLVSGELALPQKTKNKCGKGILRRDWPMKYLEKIPALIVLFLDLDWDHASWSEKKTEAENQFQHLEMILLPQNELMSCAKYVISRPVSFSSYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5T5</accession>
    <name>A0A0D8Y5T5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y5T5"/>
    <dbReference type="OrthoDB" id="5834297at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10734" checksum="871B467032474EE5" modified="2015-05-27" version="1">MKRDSTQWRMPTLPGHHRNVSQGQHLIVDRNESGDEDDTEHGRVGILPGENRADLNTSPHYLPQNNKPNCLPTGLEEVWLSFNLLPFFMVLDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Z0</accession>
    <name>A0A0D8Y5Z0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">DICVIV_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5Z0"/>
    <dbReference type="OrthoDB" id="5856915at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="447" mass="52542" checksum="F5640C6973C09796" modified="2015-05-27" version="1">MQQEAKNSWEHDFVDLIPPPNWDDYVLPRTIKHYMEYEWSLSTYSNECGHENPLKIVPVYFWPGDQVDLPCLMCELAFVFNGKMKMWGKAVNIPKFLENPKRNARLSLSNKWSQIRNSNKTLTSSSDSEIVDRMPGVRLSDGTIVYGNKLEPYYIQRKGKLSIIHAGPSSQGVYFCYDTQSRSHTSIFYVVMAMTPPVSITEMKEVFSDGCYDRTDKGFIRANFNWRYHFVPNVRHEMPRHCHHHKKTFCEADYFTQVMTKRGCTLDFCRKEFKNGDNELNLALELRWEPWSECVESRQLQKREAHCYLVRKFGYDIPVDNLDEQHNWMPKLNSIFNHEPFTSKGIRLYSSLLASLFVDEDVMTKCFYEKKSRKTDKIWRLILRTMGLNGTMVELDENGKIFGTPPTLRLINPFHACMVYEYDRNTRYEKVVGSYMTETRTCTSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y637</accession>
    <name>A0A0D8Y637_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BCD1 alpha/beta domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y637"/>
    <dbReference type="STRING" id="29172.A0A0D8Y637"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="1">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16100" checksum="19B3ACBD9B0EA48F" modified="2015-05-27" version="1">MTPFIEGGIESLNGFMPVPNYEPERFYGINFEKDLLHNTRNRVIVNHPKIIITLDTEFISSHQVRGFFQLFNTYVLLLRSLDDDFDPFEPFEGPVRLPQSYLGAHETNSNSDEAQPKKHCVDQNDAIRKWGECIAQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6D5</accession>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </location>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">HannoverDv2000</strain>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7U2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7U2"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="364" mass="43015" checksum="9E8BD07C1C08C536" modified="2015-05-27" version="1">MARYDYQPKYGLENYTVILPLEDTFDAVRSTVWMQRNWLHSVTLSVAYVVLIYAGQKVLNTCMKIVLHIYFIYFPKSLCSCRIKICRILVDSFNRVHYIRLTGKCVKIMEGRKPFAFNVPLFLWNVGLALFSILGFVRMTPEWLWSWTENSFVYSICTASYAQGVTGFWTEQFAMSKVAELLDTAFIVLRKRPLLFLHWYHHVTVMIFTWHAYKDHTASGRWFIWMNYGVHAFMYTYYALRAMRVRLSKHIAMVITVLQISQMIMGIAIGVTVYKVKTSGEECQQTWENLGLCFLIYFTYFLLFCNFFYHAYLKKNNRYVSETQVQNKVEEESVERLKEDINANISATAVMTRNITRRRLQKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8H3</accession>
    <name>A0A0D8Y8H3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8H3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8H3"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13833" checksum="C724E4B1726F6DDF" modified="2015-05-27" version="1">MLRNARKQTRKFSYTRLLEPTNDLVACASCGSFHQVDTICGNCYEKVRQLTNEIKRKMMAYNPYKGEQQDKEVVVRFSNDNIVEDGVFKGKRVIEIEKERPTISFHLTSCCASMKSEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8J6</accession>
    <name>A0A0D8Y8J6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8J6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12274" checksum="AC864CC55F7B048D" modified="2015-05-27" version="1">MIAITSALNDQDCYGHRRIVLEQLSDSETTSSNRELLNASNSMTSRIYAHPIQRDNVLSLSSIAATPIIWWLQPTRHTIRVTNHTPSSCVKLTYHSRDFPLIKTSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9F7</accession>
    <name>A0A0D8Y9F7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_00493</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Possesses 5'-&gt;3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with paxt-1 (via N-terminus); the interaction is direct and results in stabilization of xrn-2 in the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9F7"/>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="13225" checksum="7DD67772CBA1DF84" modified="2015-05-27" version="1">MTASASSLIDVVKAGCSLWRCMLARDKCISTVFQKIPISLCCCSTDRCNIEQKQDFRQQVNVWNMQPDQNEFELIQNWTREEMVHKFHSTNLDDDLSATSRGYQNNETEEIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAV4</accession>
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            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="9" type="ORF">DICVIV_00445</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052012">
        <property type="entry name" value="GTase_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21645:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN F59C6.8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="513" mass="59703" checksum="ADF3DFEB1107B1D4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBD9</accession>
    <name>A0A0D8YBD9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ET module</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    <sequence length="155" mass="17592" checksum="24B80D7013AA16E0" modified="2015-05-27" version="1">MGLSDFHYVYTFCFHNFIEAVSKIMSFISLIALLGIIYYCASLECYTGFKYISGRSIGTSKITCSSPSDYCYNATADVSQLNKLSMAGCSTTRCFVRFHFEIQLSRNKCISQMFKGREIKFCCCNSGDLCNSKYSNLTFYQKVKERIKDLGKIIG</sequence>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <source>
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    <sequence length="275" mass="31252" checksum="CBCA68150827107D" modified="2015-05-27" version="1">MVNIPYRSKLTEKIEPGQTLIIRGRTAENAKRFNINLHKDSPDFSGSDVPLHVSVRFDEGKLVFNSYTKGAWGKEERQKNPVKKGDGFDIRIRAHDNKFTVAINRKEVKSFEHRVPLQHVTHLSIDGDVTLNHVQWGGKYYPVPYESGISEQGLIPGKTLVIYGTPEKKAKRFNINLLKKNGDIALHFNPRFDEKCVIRNSLVNGEWGNEEREGKNPFEKGVGFDLEIKNEEYAFQIFVNGERFASYAHRIDPHEVGGLQIQGDIELTGIQIVGN</sequence>
</entry>
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    <accession>A0A0D8YC50</accession>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="43532" checksum="39005995875116C8" modified="2015-05-27" version="1">MITHLLIALCVLANLLSSELYKVMNVKLSNESSLAATDRIDKKGIANNVTTLLNEILKGYDRHLRPGFSSERTTVFIDIFVRTMGPISDLTNTYSFNCYFRQTWTDSRLMFNGTSNQQLSLSMAMLDKIWKPDTVILALSTQEGLKGTRAVGKCAMSMRRYPLDRQACRLIIGSYAFSTDELLYEWKIMGTDRGVQMDYESISDLPQFSMTGFEVLNSTDMLRDRNYSALEVRFFFHRHFGYFLMNFYVPCTLIVLLCWVALWTNREATGDRIGMGITSVLTMVLITNDSKSDVPKVNFPTALDIYIWICYTTLLVCMIEFTVVHYYTKFNTGDPEIQAIEREKMRRIISRIPKSAVMSSRRTNRMLAGPISNKAIVSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7D7</accession>
    <name>A0A0D8X7D7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717209">
        <property type="protein sequence ID" value="KJH40448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7D7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10029" checksum="63310350A4C74E97" modified="2015-05-27" version="1" fragment="single">MFFSRASPSARRTTAAASFPKKKQKSEKIKKNSNWPIMVEREISRGYISMPVATVAGVPSGQQSTCFQKVCMANCSHVIVSLVSQKFQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7S2</accession>
    <name>A0A0D8X7S2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SKI/SNO/DAC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_13427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DACH/dachshund family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717083">
        <property type="protein sequence ID" value="KJH40610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7S2"/>
    <dbReference type="STRING" id="29172.A0A0D8X7S2"/>
    <dbReference type="OrthoDB" id="6436112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000001">
        <property type="entry name" value="Dachshund homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052417">
        <property type="entry name" value="Dachshund_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577">
        <property type="entry name" value="DACHSHUND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12577:SF6">
        <property type="entry name" value="DACHSHUND, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI/SNO/DAC" evidence="5">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="41245" checksum="36E8378B98AD3132" modified="2015-05-27" version="1">MISGQSSIVTEEFLSFDSSETAIPKEINYRGQTVVGFDLKGTDMLCLPQVYELFLKNMVGGLHTVYTKLKRLEITPIICNVEQVRALRSKNAIQPGVNRCKLIAATDFDRLYDDCTNTCTRPGRPPKRWSNVEEWSVKREKFRDLTQRCGVETDYCGVASVSSPNSVLFGQFLPQFNAQQLLVQQMMLLAATQKQSEICGASSSLGISTDAATIDGGIPLNLSKSTSNSETSDNDSLENMQKEGNISPNQSISFDRGVSNGSNNSSSSSEQSTDATTKIISLIDMASDYFKQQMESIRKEKEEIEFLRCQLKGSLIDGNRLREQLRVEKKKSNIYFRRYCKARREMILLREQMSDMRNNPMTSTLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X876</accession>
    <name>A0A0D8X876_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_14255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719827">
        <property type="protein sequence ID" value="KJH39849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X876"/>
    <dbReference type="STRING" id="29172.A0A0D8X876"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF32">
        <property type="entry name" value="STRESS-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="95"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH39849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="205" mass="23890" checksum="54A2E244F371B134" modified="2015-05-27" version="1">MRPFFDLFPRLPAPITYKDFDNYGQCVDFRPPIVVPSLWFLLFPAVAKQFVMALWPESRFGHPLRDFVNELETFSRGTDWFGREMQQMYRTTDQIVLNRANQSHEIANDDKKFAVDLDVSHFKPEELKVHIEGRILTVEGKQEENTDHGYMERAFVRKWALPDDCDMDAIHTQLNDVGHLSIEAPKTGKHTNRRTLSINAAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8V6</accession>
    <name>A0A0D8X8V6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_13043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.</text>
    </comment>
    <dbReference type="EMBL" id="KN716937">
        <property type="protein sequence ID" value="KJH40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8V6"/>
    <dbReference type="STRING" id="29172.A0A0D8X8V6"/>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000054">
        <property type="entry name" value="Cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12303" checksum="7F60A1091417AF6B" modified="2015-05-27" version="1">MPNCPRCNKPVYFAERVTSIGKDWHRPCLRCENEACKKTLAAGGHSERDGKPYCNRCYGALFGPRGYGHGGVESHTFHHGQTGKRDVLADRREVPNRHIVSYKFIRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9E6</accession>
    <name>A0A0D8X9E6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717256">
        <property type="protein sequence ID" value="KJH40397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9E6"/>
    <dbReference type="STRING" id="29172.A0A0D8X9E6"/>
    <dbReference type="OrthoDB" id="5870642at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32487" checksum="674D6D5BF607CEA5" modified="2015-05-27" version="1">MIVVPILLYTNEDDLTLLCWYIFKLLVSSVGKIVEDKVLDSGQRATKESMIYLSTIGLPDAEGCDSETIGWKHNLKFTLSTLLDTSLLYSPSFLILAVSGFLTLSCFYVPYNYLGQHLDKIKNLTQTQRTMPVSLLGIINIAARIVCGWIADRPQVDALLVSNLALIAAGIATCSVPFFTEFWHFIAFCIPFATGVACFAALRSVICVDLFGLAKLSNAFGILLTFMGFGAIVGSPLAAFMKDLTGNFDVSFYVMGFLMTTSGAICMPLRKMRIREEKRAQERDAAHVTELAKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA17</accession>
    <name>A0A0D8XA17_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_12587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716825">
        <property type="protein sequence ID" value="KJH41435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA17"/>
    <dbReference type="STRING" id="29172.A0A0D8XA17"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH41435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="375" mass="43709" checksum="98F9015BF444F30A" modified="2015-05-27" version="1">MTLDSKTKKADDIISNQFLAAELDEVEKLIKEAFVLSVISVILTVLFYIIAHFFNNSSKCFNLVLKFQIPYKMEIVWRNVILFAALHVGALIGLYQLIFVAKWMTLFWTFFLHVAGGIGITAGAHRLWSHRAYKANLPLSYFAYAYGHYSISGEFEIPNDVIEWARDHRCHHKWTDTHADPHNTNRGFFFSHMGWLLVKKHPQIKEQGKKLDLSDLYADPVLVFQRKYYRPMVVLFCFLLPTVIPVRFWGEAPLVAFYTAALFRYCFLLHATWFINSVAHMFGYKPYDSRITPVESVWTSVTAVGEGGHNFHHTFPQDYRASEYSLKLNWTCIFIDAFAAIGWVYDRKYVPEEYIRRQCANYGDPGKRNKWSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA48</accession>
    <name>A0A0D8XA48_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717156">
        <property type="protein sequence ID" value="KJH40509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA48"/>
    <dbReference type="OrthoDB" id="5905850at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="15263" checksum="E517E9B7A53187CA" modified="2015-05-27" version="1">MALIPQSLKSHFYIEVFRLPEFCLVSCYKPFHMSRFTHLAVFKSILCSIFLLVASAQHNTEVSKGDKILNFTISGFKLPLPLMYTDDASSFAQFPSASTSEHSAKAFARNLIARAVRSNFFSSFTSELLGKVIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA58</accession>
    <name>A0A0D8XA58_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717149">
        <property type="protein sequence ID" value="KJH40519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5865602at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052664">
        <property type="entry name" value="BTB-MATH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743:SF165">
        <property type="entry name" value="BTB AND MATH DOMAIN CONTAINING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22743">
        <property type="entry name" value="MEPRIN/TRAF-LIKE MATH FAMILY-C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="756"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149691" checksum="5ECA87D8A1E78E92" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAC4</accession>
    <name>A0A0D8XAC4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_13351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717051">
        <property type="protein sequence ID" value="KJH40687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAC4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAC4"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF89">
        <property type="entry name" value="POU DOMAIN PROTEIN 2, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH40687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="29778" checksum="59306FE5FC6640B1" modified="2015-05-27" version="1">MNNFSTLELLQILRINEVSRFPKPFTGDSCCQVDSERPDVIQRLPHPWSYSFPTEDAAHSQLSDDSEPGCPDDLEAFAKQFKQRRIKLGYTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLFKWLEEADSTSASPNSAFEKMTGQGGRKRKKRTSIEVNVKSRLEYHFQKNHKPNAQEILQVANELGLDKEVVRVWFCNRRQKEKRMTPQFDQQMMITSPYPPPDIFSYPNGLPINPSQFEIRTSSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAL2</accession>
    <name>A0A0D8XAL2_DICVI</name>
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        <submittedName>
            <fullName evidence="7">START domain protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XAL2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STARD3"/>
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    </dbReference>
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        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="436" mass="50237" checksum="C73B93CFF2EF304D" modified="2015-05-27" version="1">MSGRSLLLNAESPILSKDRRRFIIISIFDASLITLLWLLCTVTKGDDWRKAFLQEVNLFDPNFMNVSLFDIVLCAAVRMVVLILFFAVFVVHHWLPVAVTTSLSTIYIVIKILFFFSHKQEGLPQYLLVLASFSIAWFELWLVPFKVLPGERICEHRDSFTNILNESASVSGNFLAEARRHNPISRSYISEDEFRSAVEFSSDDESRHRYVFESQKLNEELITTELKAIYEKSIKDAHDKIQSELRQARLGEWKILKCNGPMILQSPNSSYYIRSEFPCSPLTLFNAAWRDVPQWNKQLLDGRVLGNIDSVTDLYYSISRPFLKGYIGSRDFVDLRRIYCDAAIQVYFGVFVSVDFPPIPEDPTKKIIRGVNGPSCIRTGCDAATGKSYLEWIMCTDLRGGLPKRLTKSKIHSYLIDHIKNLHEFIERLPERQESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAQ4</accession>
    <name>A0A0D8XAQ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATOR2 complex protein MIO zinc-ribbon like domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13194</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716996">
        <property type="protein sequence ID" value="KJH40842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XAQ4"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:GATOR2 complex"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="371" mass="42224" checksum="E516C1BE7EB0F5D2" modified="2015-05-27" version="1">MKLHGKQVPELPQISSVWPTHFTRFVSHYSNTYRLKKEACLSSITSLRNLELAVNNVASGDFYFGAGELTQTTIEKGAENPHYNDFTGLKDEAFFLKPDLTKLSFMSISSDDDGYIEKEQMARVNWDPMQEVARILRYHADQGDMQTCATVALVCGRRLSKVIDDFTVEAWQESYITMLDQLDLHTAIAGIKKYSWIKRLNQRSLEGTHFRLLHRNCTGQVLKCRCMKCSSVCGGSCSICNRTLVGMSWFCCKCHHTSHPQHMLEWFTTERVCPIGDCSCECGTNILQLSGKKVPVTLTKTSCNLTRVSEKRCYLPTLSDNDHSGSSSDEELDFHEPREDSRNKIFSFLLQESHQSIFLQFIGKIRNSIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAY3</accession>
    <name>A0A0D8XAY3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722206">
        <property type="protein sequence ID" value="KJH39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAY3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="13146" checksum="FC46FB40819B4964" modified="2015-05-27" version="1" fragment="single">MFYYYQRRKWNGLSEWLVLEAKSPLRRRTSGVKPSIGDRDHLAVDEVRHSEEFRKGRVAIDFDFNSDTEHHEEKSRKKTHTEKKIELSSAMSTKKPSHSCCDRKDTVYLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC51</accession>
    <name>A0A0D8XC51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716876">
        <property type="protein sequence ID" value="KJH41224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC51"/>
    <dbReference type="STRING" id="29172.A0A0D8XC51"/>
    <dbReference type="OrthoDB" id="5867434at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24072" checksum="71F088BB1670C9F7" modified="2015-05-27" version="1">MKTAAVPEKRPPGNRGRKAEFLTNITKLSLKPNVDFFKYDIRMYVVYKGEDSREHLKEITKQKKDYFPEQQRKSLTVLVYKHLIESYPDVFPKNLTLFYDRGSMLFSAYEQIKLATEKEEFIIPASILSNACGNAEKVSVVIKKVSEKFQVSSNDVMKAVDVRDIERDKNMLEVLNLAVSQEGYLETTKFLVSGPNVAYLFDHGACHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCE9</accession>
    <name>A0A0D8XCE9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Eukaryotic porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716687">
        <property type="protein sequence ID" value="KJH42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCE9"/>
    <dbReference type="STRING" id="29172.A0A0D8XCE9"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="11">
        <location>
            <begin position="301"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="505" mass="56947" checksum="FB38DF21B5EA13B0" modified="2015-05-27" version="1">MSQPTGESTATPSKPSTNPGSYEELHRKARDVFPTCFEGAKVMVNKGLSSHFQVSHTLSISPTSTGYRFGATYVGTKVVGPQEQYPIFLGDTDVAGNTTATVVHQFGENYRMRLQGQVQQNKLVGAQGTFERRGRLTTFGLTFANTDVVNESGVVVGQLLRKLTSRLDVGAEILYQYGRQIPGQKLSVLSYSARYATPIWTAVATLGYSGAHFTYYHKQTDNLSFGVEFESNANIGEAVGTFAYQAELPDEGVTMRASIDTNWSVGGVFEKRLSQQLPFTFALSGLFNHSKKFKNTAGDMVIKFTSNVVDPPALLYMGVDKYENEKLIKYGWPEDVWFHVDKVSSAHVYLRMPPGMTIDTIPQALINDCCQLVKANSIDGNKMTDVGVVYTMWENLKKTGDMDVGQIGFHDHKKVKRCIVQKRINEIVNRLNKTERREEIDYRAEREQRDMAQRRLQRKLEQEKKALEMKEAEEREALRRQRHYEDVDWNAQNDTGDGNLSDEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCT1</accession>
    <name>A0A0D8XCT1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mon2/Sec7/BIG1-like HDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716794">
        <property type="protein sequence ID" value="KJH41582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCT1"/>
    <dbReference type="STRING" id="29172.A0A0D8XCT1"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="265" mass="29697" checksum="BD0AA960FA288A6B" modified="2015-05-27" version="1">MSDDIEEWFLCIRGFRLGIRAACVLRSRLERNAFIQALARFTLLTAKNALGEMKGKNIEAIKLLLAIGDEDGDFLEDNWIDVIRCISQLELAQLIGTGLNVMKSTGALDERTLATLQGALGETSSQAVVVAVDRIFQGSCRLTSDAIVSFVRALCAVSKEELNQPAAPRMFLLGKLVEVAFYNMGRIRLEWRRVWEVVGEHFNAAGCNASEIVAHYSVDALRQLAIKFLEKGELPNFRFQKDFLRPFEVLYLSIKAQTYLEGNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCT3</accession>
    <name>A0A0D8XCT3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_11571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716664">
        <property type="protein sequence ID" value="KJH42435.1"/>
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        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42435.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="396" mass="45784" checksum="AA384923E42A22AB" modified="2015-05-27" version="1">MLRNGNSNVMYLRKAQKLLDGSHQIRIDSHHVGAPGHGAGHGHKKEFGPAMILYYLASAFRALYPRLDDDFVDKLNYYYTTTLLASFALLVSAKQYVGFPIQCWVPATFTDAMEQYTENYCWVQNTYWVPMQEDIPREIYSRRNRQIGYYQWVPFILAIEALLFYVPCILWRGLLYWHSGINLQGLVQMACDARLMDSEVKTRTVYTMARHMQDEVQLTNIDRSNHSRTCFSSMQMGTNCGRHCGCYVTMLYIGIKILYSANVLLQFFLLNHLLGSNDLAYGFSLLKDLMHEIEWEQTGMFPRVTLCDFEGVSFVRKYLRVLAEHPAKPVADDVTLRKFTNSFLRKDGVFMLRMISTHAGELMSSELILALWQDFNNVDRSPAQFWDAEHGQGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD55</accession>
    <name>A0A0D8XD55_DICVI</name>
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        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="ORF">DICVIV_12433</name>
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    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716793">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5851074at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="340" mass="39644" checksum="8E2A558B98E98BF7" modified="2015-05-27" version="1">MNYVILPLLMLRCSSESTKSYLSGFELRCKRKIKHPLDNACNQVESLELPAITICPKVPDALNSTALLNHIRISLPEIDNATIIDLVRFWIGGNGLENMDVLSRYNRTYLSYLNHLYQKWSNGHSTEDFFHLMQKKFGYSCNELFQECQLGGRLINCCDDLFRRQIVMRRGICFQTRKGLNQTEADDIGRLVLSIKTLPSITSPQYNFIQPQVVVYITDNFEHVIDFPRFYLYPNEWNRIRFTARYIELIESDDVCTKEIFGKDAECLVRRWLLSNIVYPFNCTLSYLSHIDNLPPTNGICKPNVIAENYYKNIQLIWNHVTVNEKVCSEDPLILKEFIL</sequence>
</entry>
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    <accession>A0A0D8XD90</accession>
    <name>A0A0D8XD90_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717271">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XD90"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174:SF0">
        <property type="entry name" value="HD PHOSPHOHYDROLASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="220" mass="26311" checksum="31590AFEB840B360" modified="2015-05-27" version="1">MESGLETRWRDLTSFLSDKTRDKWYNRIIEAYTPRDFRGVPHLCAMFCLFDKYKDHLKDRYATAFAIFFKKWVFCHVFLRECFLLVLYTIHLLLITPRRAPTYCIYLRRTQHWIRYENYVADLITASGSYSTDAHYTEGVSGEEDVHYLIDFDMAFLGDDDDQFVEHEKAQRKEYAHLSDDEYRKQRIKVQIILILLLVSLLVLFFCTTMPGILNTFLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDP9</accession>
    <name>A0A0D8XDP9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716741">
        <property type="protein sequence ID" value="KJH41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDP9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="102" mass="12104" checksum="1F0E63F875728780" modified="2015-05-27" version="1">MTTSLLLKRQSRYRNCFVSEECLLSICGYTQLSTYGNYECLNQLYYYTSIFQLQLTICNDSYLVILCNRSKHECSDTEVFALFYIQSTDIYENHRRLLPVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDZ3</accession>
    <name>A0A0D8XDZ3_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="29172.A0A0D8XDZ3"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="12931" checksum="243B33F58307B8E0" modified="2015-05-27" version="1">MPLNSHSIAGIPEFRGSTTAARYRKSSVTDPIRKRSLAPIGQTDGDLLLDPITITQMVNLGNHFDSPVENVRQCVLLHPGDDPIIFTEMLSLENDEVGYIWKQKARFVRHAIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XE57_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="73"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="29767" checksum="6B54065D5ADC15F8" modified="2015-05-27" version="1">MSSPFNLESVDVALRNAIKGPESHEVRRIIYGRDHPELAVSSDALAIADSNKFDIRAYEITALPEQLRAPRKVRVAAIQFSFPTPTTAPIQEQRKAVHRKVTKMIDAAAIAGANIICFHELWTMPFAFCTRERLPWTEFAESAEHGPSTCLLSQLAKKYGIVIVSSILERDETKDDVIWNAAVVISHTGSVIGKSRKNHIPRIGDFSESTYYMESTLGHPVFETVFGKIAINVCYGRHHPLNWMMYAVNGAEIIFNPCAEVVENDR</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716680">
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            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="46558" checksum="D1270D2B1D1867E3" modified="2015-05-27" version="1">MPHWTWLMPGLMRASSPTLPAPSLEATNNNAQQEHEQAKWSSPSSVESNGLKTDSSTGESGNIDIVGMDGSESSTSSASTQAMIISPSCPSNIPTCPKDQKNAIFPFPQKPAEMSHPTFIYNVVKSEPPSLRNAPIAASLPIGHGHSIMTPERKHRKQQNDDYVKLIREQDLSDERISSIPIPVPQALSLDPTFRAVSEQQVVQQVVQNKRFEEVDVRESMTHLCKKLAEKRVFGSKLMAETTVAGLNHSTFPNLPIEGIMYIQHVCRKVLGDRFSSDDDFWESLRDSMRKLAARCRRVRHAKKTKSSREEGLLTGDRNVGWPDGSVAQTLQNLSLPVEKPTHSVQTTPITSERNKSADISEIKLAETLQSGLHALANASLSNQTLPATLAEMTSAWSLLQLHKNTDSLVKRDIRFNDAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716668">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="147" mass="16469" checksum="7532C79A12111D6E" modified="2015-05-27" version="1">MDDINQSFKVSKYVQFLDDCISRGTVAMGFLFAKVDDSVLSPAGKFSCFLIDCCLYSCLDENEKDGAISSCAILHSAVIKRILTIAQDYSYPLTADAQCRVIAYVFRSWDIPIEVVCHEAVDIFSMLMMNHGLECLECKSRCYALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFS8</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716650">
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="24559" checksum="D52D64C1C0A3411F" modified="2015-05-27" version="1">MKKKSPDEKLSSLRKLSTDVTFRLQKRVDTSDILFVASGAFNGLDKIVARRLDKKSLGFGTSSGELHVSSDDANSEQARKRDYLLSKADQGDLINFGIVPELVGRFPVLVPFHSFDQDLLVRVLTEPQNSLLTQLKLQFAIDNVDLTFSSEALQQVAQLALERKTGARALRSILEGVLLDAKFTVPGSDIESIHVTREAVLGEAEVEYTRRVVENKQAVSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGI8</accession>
    <name>A0A0D8XGI8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716620">
        <property type="protein sequence ID" value="KJH42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGI8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGI8"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF493">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8668" checksum="71680F8C9F0B9BFD" modified="2015-05-27" version="1">MPRYCLFGDTVTTASRMESNGKPGRVHISTDTMEFLTQKFDHYKTELRGEVIIKGKGAIETYWLLTPEEQEQLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGX0</accession>
    <name>A0A0D8XGX0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716606">
        <property type="protein sequence ID" value="KJH42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGX0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF150">
        <property type="entry name" value="PROTEIN CBG08159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="216" mass="24401" checksum="5368B822AF16FB52" modified="2015-05-27" version="1">MSTSELSPRFQLAFRRSLFFGLCLCVWLTIGTLTFSVLSSAGRKRADVAGMVRLDNKRTELLNVLWAETISKPEADWAEMANKKLELYEKALLTYMKCDDHSNDRSFMTSLRRSIAVVTTIGPVNIDALTFTGKVFAVLYSIIGVPLCLLVITQCGRMLTSLWEGRKLFIPIICFTLISAIIYDIMDNRSDDIPFFDAVFSIFLQFCTIGEVDSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI23</accession>
    <name>A0A0D8XI23_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716565">
        <property type="protein sequence ID" value="KJH43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI23"/>
    <dbReference type="STRING" id="29172.A0A0D8XI23"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13655" checksum="EE8B5B9D96D98F27" modified="2015-05-27" version="1">MLKLQVSIASRFFSRAADKDNIRFDGVSSRKIVVLPNSSVAAWHPEPSFPYEQTKPLPEKTIEDQSLLSTVARSSNRWKNGPKNVDLKNIFYTTKHEWFTRTREERLRRVAAPPAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIQ5</accession>
    <name>A0A0D8XIQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716538">
        <property type="protein sequence ID" value="KJH43652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIQ5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10429" checksum="686DCFD5B3E1C798" modified="2015-05-27" version="1">MILWHDSRGTRYGYVTRFTGTFSNDSKINRAVGKSEGRRVPLHKADAGGGVYAFQPNLVELKSLWKIVIAPAHVRKRSNGATFIGSSTRLKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJC7</accession>
    <name>A0A0D8XJC7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716453">
        <property type="protein sequence ID" value="KJH44715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJC7"/>
    <dbReference type="OrthoDB" id="10061508at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8987" checksum="EB158E02B15952A4" modified="2015-05-27" version="1">MSRQRRDDIQGFRGWAVILVILYVFYPKQFPNGYIGVDMYVSFYILYYPVFIVAMLLKSEDSVTLRTIGEFYQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJI7</accession>
    <name>A0A0D8XJI7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716453">
        <property type="protein sequence ID" value="KJH44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJI7"/>
    <dbReference type="STRING" id="29172.A0A0D8XJI7"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF183">
        <property type="entry name" value="MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="240"/>
        </location>
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            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="349" mass="39850" checksum="B2F982073A8D335F" modified="2015-05-27" version="1">MESIERTSRIYQASSGKTYFEQCFKVIRILGKGVFGETIVIHAKFRALTIRFPQEISEQLAPLRAVEVLSLEDGEHYAIKRALRTFESSGNRRMKLREVLVHESVPNHANILRLKKAWEERGISCKLGDFGLAYNLTKISTGCFEEGDKYYMAPEILNDNPTTAADIFSLGVTMLELATDVDLDKDRELIRSEKIPSGWFGDLAIDLVQVIKSMLMVDHLQRPSAKNLLDIMKRNQRPSTRFRTMEISPAASTTGMEDDDWDFKISEDEEVLKVTQITSLRSRLDFDEEDGDCSAPKKPKRGKTQQLSSFSRRLDFVMDTNESGSKPLKKRRLNFRIGRCIVFFSGIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKA3</accession>
    <name>A0A0D8XKA3_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_09783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="KJH44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XKA3"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:outward rectifier potassium channel activity"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <end position="66"/>
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    </feature>
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            <end position="99"/>
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        <location>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="35009" checksum="ED7FFD2ACA00F9B2" modified="2015-05-27" version="1">MSVDSERTEWERIAQQHLHNMSDQLFVAFEKYFLTSTEVKKNTTAEIWSFSTAIFFAVTVVTTIGYGNPVPVTNIGRIVCIMFSLFGIPLTLVTIADLGKFLSEHLVWMYGNYLKLKHFLFVRRVSRKERREHVCEHCQRHGIGHNMHVIEEQRIPAFLVLAILVLYTALGGVLMSKLEPWTFFTSFYWSFITMTTVIDCYKISNRNLFKLIRGFPGLAITTMCIDLVGVQYIRKIHYFGRKIQDARSALAVVGGKVVLVSELYANLMQKRARNISKEAFIIENLYISKHIIPYIPSDIRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKG5</accession>
    <name>A0A0D8XKG5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKG5"/>
    <dbReference type="STRING" id="29172.A0A0D8XKG5"/>
    <dbReference type="OrthoDB" id="5854641at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20802" checksum="319B3F2FFD506D66" modified="2015-05-27" version="1">MLGKSNLTVVKEMACFMCCYLLCPPTPDSITRKMAFHPPRKGQNYTVHLYENTEIKIKNASKLIGKEFFIKPAQLTKSPSSDYSNLMRNIECFVARTILGSYLICVRCCPSRSDINDIREEVVIFSQPNASDLGEYLQPFYVNIPLMADVFETEVYAFDYSGFLLQTTPTTDALISFYMHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKU7</accession>
    <name>A0A0D8XKU7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patched family protein</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11031</name>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716605">
        <property type="protein sequence ID" value="KJH42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF85">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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    <sequence length="121" mass="13804" checksum="81F5DA659D53ECD6" modified="2015-05-27" version="1">MDVPVVDGLEIIDFTKKSESGSQHPFEIRLTNGKKVLVHEENAYENYYQDGRSFDDLGQNESELIQFEFDFQVHKDGLKEMKTIGNTIHSNPMAVYHANVLWCYAYGLTVTKKENDGNTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
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    </evidence>
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    <sequence length="425" mass="47236" checksum="825D596B94B1B149" modified="2015-05-27" version="1">MKPDVKDRDYMYRLIIGQLFYDGHQQLALSLAQAIGCAAQPPPPSDKLFRLVSIAKQFVDDPESKDKQANMQFDVLSAGLDLEFDADLIPTSAEPCNYETIYLTSHKSACRTASFNNDGTLVATGSADCSIKILDVERMIAREVRGELSENGPDANHPVIRTLYDHLDEVTVVAFHPREQILVSGSTDKTVKLFDFSKTAVKRAMKTLSEVFPVRALSFHPGGEFLLVTTDHPTIRLYNVETAQCFVCSAPGDQHKDVVMDVNYSDNARLYVTGSKDGDVKVWDGISNRCVETFSRAHDGAAICSAKFTRNGKYILTSGMDSIVKLWELSTNRCLIAYTGAGATGRQEFPVKATFNHNEDYVLFPDEKSGSLCSWDARNSDRKRLLALGHTAATRVFVHSPTVPAFLTGSDDFRARFWYRKGARF</sequence>
</entry>
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        <lineage>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="153" mass="17055" checksum="CD283277ED26E04C" modified="2015-05-27" version="1">MDGFLEANLLLSSALEQLDCLIIRGSSAGCFVGDDFLQTDETFSSSQNGEKNVNEGLNISSTNYDENHKMKESNWIGKDWREHTASDGSSEADSPPSDIPTSSSSLCNTPKIYSDFVKAIEDQSIIERPNHETQLKIMQWLAGRTERMEFVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        </location>
    </feature>
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            <begin position="114"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="19913" checksum="6A69858F89B9DEE8" modified="2015-05-27" version="1">MNRKSVSLEVPVLRPLHLNLNELVYTPPARSTPICLDHSPNFSQKIKIPKKKYSYADPLQRMDTPIFDKNEISHVKKGPSSPTTVMTMAGLFVVGILLMMSGVIVISAHTETPFIVTGCLFLGVGFAMLLVCAILQRKNIIKFIHDLNSDLYFLKMNKSYMWKVMFENRAELPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="45585" checksum="74B768C955E89820" modified="2015-05-27" version="1">MDEWDLLEEVDVIALWPKEHQNNLLSSKWQERREALEALVHLIEKNPRLSTASMTIYGEVMDSLKKIIAHDSNVNVVASALRVLTRLARGLRKRFSCYVPMLLPSMLEKAKEKKSVVQDALNEALDAVSDSCDAERIAKDLCEHLLKPNPQSKQCLCLFLFRYFVRQSGLSTDFVKAVLPIVVKIVYLIIWSFQLSSDSNPSVREAACHSLGSARRVLGKSLDAFLIPISSEKAKLEKVEESCSEAKKQHEEFISQKPQSKSSEIYESGDHNEAVDSGAIISSNGLKDDDPWILMTPTDIIVQMRKDFVEMLASKKWQDRKEALDNMLSIVECSPRIATSPELQNIMAMLLKIMPIVFDKLKDKKAVIRNELVRLCDAAATTVRFLSFIHGIHIPQHDRSNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XND5</accession>
    <name>A0A0D8XND5_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2 type</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">DICVIV_08670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716416">
        <property type="protein sequence ID" value="KJH45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XND5"/>
    <dbReference type="STRING" id="29172.A0A0D8XND5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="25091" checksum="141BB94F2AFF3345" modified="2015-05-27" version="1">MLQEKTAGPQQTDVDVYITARRISHNEYSVTFSRLKPKSIRPKVDTTLNISASFLLESATKNVSIQLSLNESQVLNISCAGVVKALQGDDFVVMRAYPANPNCPSVVELLMNPDVVEFIRRCDICEVDLHTKESSDAHFLSEDHETAQLTFPLPAAFHRPVENSMLTTAAVSLQRKDERTDFTCKLCGRKFLDMEPLVAHIRLEHERDHPPGITRPAARTAPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNM8</accession>
    <name>A0A0D8XNM8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative translation elongation factor EF-1, subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716413">
        <property type="protein sequence ID" value="KJH45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XNM8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="221"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="650" mass="71647" checksum="39D92DB19BA89407" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP10</accession>
    <name>A0A0D8XP10_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_08417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XPE5_DICVI</name>
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    </gene>
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
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        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
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        <location>
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        <location>
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            <end position="422"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="881" mass="101641" checksum="933EBF340807CEE1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPG4</accession>
    <name>A0A0D8XPG4_DICVI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716348">
        <property type="protein sequence ID" value="KJH46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6510177at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
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    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF112">
        <property type="entry name" value="PATCHED-RELATED PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="206"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="790" mass="89596" checksum="AF1B0DB1F063C86A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPV9</accession>
    <name>A0A0D8XPV9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716345">
        <property type="protein sequence ID" value="KJH46585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XPV9"/>
    <dbReference type="OrthoDB" id="5576026at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10033" checksum="723E77C8A91C883B" modified="2015-05-27" version="1">MQEEPEDLSLSVSERSSRMRFWSFVKEKQENGEIVMACSSCLLVFTDPLLYRTHVNTHALGSTFRCVACGTVCDDRVAFQRHLIGAPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ00</accession>
    <name>A0A0D8XQ00_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716472">
        <property type="protein sequence ID" value="KJH44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XQ00"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase mTOR" evidence="2">
        <location>
            <begin position="809"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1519" mass="171619" checksum="D17AE44F1F583915" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQV7</accession>
    <name>A0A0D8XQV7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 14C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQV7"/>
    <dbReference type="STRING" id="29172.A0A0D8XQV7"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="11325" checksum="FB167D4FB8DC94B7" modified="2015-05-27" version="1">MLPSPEQVNPWYAGVLAVGGVIGFVKAAISILGSIPSLVAGAGSGAVVAAFTFLDLPYKTAVVAGVAGVLTYVMGMRFANSQKIMPAGVIALASVAALLVQLNHISKTRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJH47198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8223" checksum="1C84F448EC9EC5E3" modified="2015-05-27" version="1">MSLILTDKQCLKNICINECHILIDVNLNLIGIPMNIDMLSRFRRMKEVKAHVSKPLPPCKFSTVDIFSLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRI0</accession>
    <name>A0A0D8XRI0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_06629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">HannoverDv2000</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Type_1_exporter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
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    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        <location>
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            <end position="400"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="530" mass="59282" checksum="298251DE1BEDFE52" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTH7</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8015" checksum="A39EF2686452B2BE" modified="2015-05-27" version="1">MQQHSNPMGICCSCIRLMLDGESDVKVHVIEPTSIGVEHSAAAPATVQYRHVERSGLTLQVPEMHRVHRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="158" mass="18139" checksum="D6A7C4FBAFA72D0B" modified="2015-05-27" version="1">MMEGTVVSIVLVLVHRTSVVIPRLVVMLYDGRTRFVFVYHFLRNDLGVFEFLSRGQISRSHVDLKAFRDDSCLERFSSGVRDPVSFTHSLRLDSAVELSNIPFTNYTLDFKGMIDYIFSTPQSLARLGFLGAFDSTWVAQNKIIGPFFLLLDWYQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU89</accession>
    <name>A0A0D8XU89_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716310">
        <property type="protein sequence ID" value="KJH47382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU89"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19962" checksum="E7D11D2C067D3576" modified="2015-05-27" version="1">MYYLVLIASSFSEQLLLGSATRRLVDCLSIWNCVYIWSTSESCSLICIHSYCKLTKFTKQFHREFGLFGFVVVRRHRSRNVVHQRESILAIRKHLLQSVGIGPSCEHLRFIVNACFDRNGSSFVDKIPSEMASCTDCIDHLLLYGMDYIDRCRITVFTYCKISKIRQSRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUG4</accession>
    <name>A0A0D8XUG4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716274">
        <property type="protein sequence ID" value="KJH48238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XUG4"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="477" mass="53911" checksum="D9AB740649905764" modified="2015-05-27" version="1">MDYISSFDIRLDKEIYYAGERLSGNVLLENTENIKIKGIRVLLRGKVHASLKVVKSGERRTIKDDQYVVDEKLLIWGKDKCEESEVVPILARGVHQFPFVFHLPQTTLPCSLECRYGTIRYYIKKKLVVSPMLQVIIDIPYASSPQGVKYFTVIGPHIDCMEEKYLSALSGQDRKTTCCWCCRRGALALRIVLERTAYVCGENIRIRAQVENRQATLQMILIKLIQHVELFIDKGVLGESKTLTSVVFEHKSSAITPNNEGKYDSSIEQSIRLPVVPPTLIGICRLLQIYYILRICLVDEKGSECLHLEFPLTVATVPYRIPNAPPPPVDYDFCVNHVEGGKYVSPEFRLGHVYDGEGDEEVREEEVVLYRPVYVKLAERGNGSSSSGKDFRSGSFTRITDSNYSMITESNGRRRSVVISSPEDLSEPKDERIQSVLNIRLEGNDDDVNTPLIHNNSSARVQSDPVKDADIKECSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUX1</accession>
    <name>A0A0D8XUX1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716302">
        <property type="protein sequence ID" value="KJH47564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUX1"/>
    <dbReference type="STRING" id="29172.A0A0D8XUX1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45044" checksum="CED00317B986EFD8" modified="2015-05-27" version="1">MRDLEISGMRLSSSVSTEWNVVISEPGSPDVEEKMYGSYNHDQEAESPRVYFDDDESGSLEGMNRDFDYSSLSINLQSGADVTAQLIPVPPDGGYGWIIVLAAFFSNLIVDGVCTSFTEFKNSYSQYFHASDAATALIGSLLIGVYLLVEKLIDFSLGPVVGGLVNKYGARKVVVTGGIGFGMIYLPAIVAVGYYFESKRAIATGIAVAGSGVGTMIMPFITDYCITSQSNHFYFGNRVGSSNIQDDIFPEFGWKYTVWILAVIVFLCALFGILYRPLKAPSILQKDQELIPLRAALRKMSEADEENRAISQMSSDQDSPVKRYSRIEAENVHDDPVMARLRNALSECENDNDTSPSTPVRQPLSPVLENAMSKNRAGSAYQAPTTTSTRSRKQTLTSGMASQGYYSYIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVM2</accession>
    <name>A0A0D8XVM2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716291">
        <property type="protein sequence ID" value="KJH47824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVM2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVM2"/>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF15">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335962" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="15822" checksum="53DC071D64092BEC" modified="2015-05-27" version="1">MLIRTAIFCVATTVVVFSEKSPNEKLKECCRGLKDADKECVDKFCDFNAISQTNILSYLSTCSERGPTVGNMWDCASLRHDHTNCCKAKGVEGKCLEYCAAHDGVPTNYLDYLFCVESFNEIRDCFMSHLEKNPAFKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW76</accession>
    <name>A0A0D8XW76_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_05879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716283">
        <property type="protein sequence ID" value="KJH48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW76"/>
    <dbReference type="STRING" id="29172.A0A0D8XW76"/>
    <dbReference type="OrthoDB" id="5799392at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF3">
        <property type="entry name" value="CC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="212" mass="22206" checksum="B0CB4F46340DC3B2" modified="2015-05-27" version="1">MFGLGGARLFNAPLKVVDSHLKIIAEAVIYDSIDRLEQADCSTVANIVKVALLVKQHGPASLTSIFIRVGQWYNIKSSLLFYRLGYCPSGQLSEVRCSGRNQCQRGQICMTGLCCTATGNEWSQACGGMAALGSCTNGSCGVGVCTASNYCCECPVGRSAGRCSNNLCPAGYTCQSTGFCCPSCSNNVMPFGACVNGFCGGGKRCCLGNICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWH8</accession>
    <name>A0A0D8XWH8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWH8"/>
    <dbReference type="STRING" id="29172.A0A0D8XWH8"/>
    <dbReference type="OrthoDB" id="5826070at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="81" mass="9654" checksum="25FF7CA156C6D172" modified="2015-05-27" version="1">MEKWVLGYLASFMRMSIREPDSIALLKTAQIKKSTIRRSSILRDLKRVKNYDHRRGREQRSTECECMNKINVRLSTIRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWI5</accession>
    <name>A0A0D8XWI5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7622 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716248">
        <property type="protein sequence ID" value="KJH49013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWI5"/>
    <dbReference type="OrthoDB" id="5774155at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056039">
        <property type="entry name" value="DUF7622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433:SF21">
        <property type="entry name" value="DUF281 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37433">
        <property type="entry name" value="PROTEIN CBG25136-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24602">
        <property type="entry name" value="DUF7622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336167" description="DUF7622 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7622" evidence="2">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="272" mass="30817" checksum="37DB5824AF9A93AD" modified="2015-05-27" version="1">MTLFSSLLILFVVYDDVISLIHCKKCGYDFELEEETCDTDCMGTVCYYLEYYYSQPERLLTRKGCISGRAPSNGCRINQNGQMLCLCEQSELLKLTIILNFYSGDFCNEKKSTLVENIPTTLPFQVCKREFMNGIDPIQRWTPPCAGNFCVYKKSMFTHENGTIGYSHSMDCSISSDFDMFFTGLPFLFYPNCCAKLMYGGQMDEVICYGSMPDASEAVFPTEGLIECYADFMSKHLPYIPTRKLCAGQFCVISASPHGDVYRYCTGGSFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX37</accession>
    <name>A0A0D8XX37_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX37"/>
    <dbReference type="STRING" id="29172.A0A0D8XX37"/>
    <dbReference type="OrthoDB" id="5825916at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="442" mass="51066" checksum="A6D809B3E8219D4C" modified="2015-05-27" version="1">MSTENAKRITRFSLASDFEPSLEGLESHRYMRRLGECFVMDSEPDSGHPTPRDFENIGDVSESPDVSISPLTSTPIAHRQRETSFHHYVQCGFCTDFGKDFLNVIFRSETYPERVENSSSEIFVESAKQLILTTEKNRQLTKENERILNQTIIWNEEKCNLEKKLRDANMLSDSLRLEVETKNDKIYWLEKRLLSLSNVASDQATDEDCKVSVELRSEKKDVSIQCTPQDGNMNYARRKVSHEEPECWQEDCAFMEMENCEMRNDKKQFFREGGVKTPYYAENGEECKRLNEKINALQLECTNLSEVLVKNDELVKSLSNANMIIAMKEATECDLKLKLEKSEKQIHDLKNTIENMERIVDDKVAETKKLNEDCDKLQKMIGRLTDENVSITVSNEELKKRLSRANNEIEELQSSVANERKTCQAAQEASSNQNDLRVKLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXD7</accession>
    <name>A0A0D8XXD7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWI domain protein</fullName>
        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716239">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XXD7"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
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        <property type="entry name" value="RBM25 PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="48459" checksum="F70FC1375036DAD1" modified="2015-05-27" version="1" fragment="single">FRKDLGKRGSFGGKESETDDIKHDPVIFVHGVSDIAGNKMKALAELYKESGYTEAELYSTTYASGSKKNPLQWTMYSMRCNYVKQIRALILAVRFYTRRNVDVVAFSLGVPIARKAILGAKNIVKKSTFNIKNLLGTCVETEENLGGSLSHYIDTFVGISGPNHGMVFKVAGLPLATCALGILPICDHVIGLYSGLCPLESEFLDDINRKYHYEGNRVYSIYSHADEKIGYKVCNKVRNNLQSNNCIFSLLLTKPSLVTSFIEGEDGHKSFRNLLHDDTLRTTHELQISMIQGRFESVNSDVIPKKHNIEALRYKQLNNITSSGTTTSTPVDPEKIQFTELSVSDKELSDAIIDKTSIVEPQEQNIHSIRRFFRERENEPRDQVLPISSNVPQHLTETSSFYQNTSEIHDTTDTNVAEEGGYHTRISFELQ</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="66" mass="7786" checksum="E2D0CBD3394A517B" modified="2015-05-27" version="1">MEEQICPTDIRLDPAYYAIYYTYMYTTFLAIGPLTLLIILNICVVFTVFTRRTADSEYTCVLRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16166" checksum="77A35995123AF952" modified="2015-05-27" version="1">MGIRCTCQHGPLECEKNSLQSCVISYFPETDTHLEIVNCIQGASEFDESVQKCLVEHKPPLRVPSDRLVRCALSDGGRSLMGYHGVVQHYRASRLQWVPWIVINGVRDNEAERDLKRVLCTRYLKPRPSICEAYPIDPTEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0E9</accession>
    <name>A0A0D8Y0E9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase CHIP</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING-type E3 ubiquitin transferase CHIP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KN716228">
        <property type="protein sequence ID" value="KJH49617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0E9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0E9"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000124">
        <property type="entry name" value="STIP1 homology and U box-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041312">
        <property type="entry name" value="CHIP_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18391">
        <property type="entry name" value="CHIP_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="252" mass="29378" checksum="670B6294BFEB14A0" modified="2015-05-27" version="1">MESTEDLRADGNRFFQQGRYQEAIEAYNKAIIRNPHVSTYFTNRALCYMNLKAWNKAAEDCAKAAFLDRNNVKMNFGDEIHAQMRLARREKFRVEEEKRLKEELIGKQRRLIDEDVNRQIAELLSATPSEEGEHDEEKSQNLEQITQRGEQHKAQLDALFAQVDDRRRKREIPDFLCGKISCALLQDPVITPSGITYDRADIKQHLHRVGHFDPVTRAPLTEDDLIPNLAMKEVLEHFLIENPWAKYEDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0G5</accession>
    <name>A0A0D8Y0G5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0G5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0G5"/>
    <dbReference type="OrthoDB" id="5857313at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="10509" checksum="20C8CABA9583F283" modified="2015-05-27" version="1">MYESKNLTLLRERWPEFPHYYKPFRPYRITRDLTIMPGATLWIEKGVEVHVWPNVRILVLGDLIADGTYWEPIRYETFINRASSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0N0</accession>
    <name>A0A0D8Y0N0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0N0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0N0"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="20254" checksum="00B3B9AB689D433F" modified="2015-05-27" version="1">MCRRIGTIMCVCNVAQLSSSFLMVLFTCSCIIATLIVDKIPRRAMLLTAGTSCIFSLCTFVIAADYGFKYVAMAGIFAFVFSYGIGVGPISWSIPPELVPLQNRSAMFCLCYAVHSVLVVLTNFSTIPLLETIGTVCFLPIYIIPCSLALMYVYAHLPETKGRDPLDILHELRGMSIKERMVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Z8</accession>
    <name>A0A0D8Y0Z8_DICVI</name>
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        <submittedName>
            <fullName evidence="6">LBP / BPI / CETP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_04186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0Z8"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF143">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
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    </dbReference>
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        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336121" evidence="3">
        <location>
            <begin position="20"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="5">
        <location>
            <begin position="355"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="577" mass="63805" checksum="F0395B2C5F7F769C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1A0</accession>
    <name>A0A0D8Y1A0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin--protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1A0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1A0"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="14930" checksum="425FEC967BE1B6D7" modified="2015-05-27" version="1">MEGSAKILVCLEECGYSRRLIGLELTNRPPEGILAAPIDEENFFEWECLISGPEDTCFANGVFPARISFPQDYPLSPPKMRFTCDLFHPNIYQDGRVCISILHAPGDDPTGYESSSERYDFLYTYEKKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1M4</accession>
    <name>A0A0D8Y1M4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042816">
        <property type="entry name" value="Nsrp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938:SF4">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NSRP1_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="390" mass="46138" checksum="C83BF799DB781B90" modified="2015-05-27" version="1">MSSDPKEDKRYGLIVRKKVVQPIVRTLPNVFDDVDDEECEKVDVSNRVHSASTIRVQKHAERLQELAIAEDPTIFDYDANYDRIQAERDEKIAERKKADKERKSKYALDIIKAHKRRELEQHSREERQQQKERKEEGEQFADKEVFITNEYRRQMEEVQKFREQEAYEKRFNDLTSVEHQKAWQAGFGRTLLSELARGEQSLMQKGSLHEGNDTVKETKTKIRNIRQRQCSNSKSSDEEASVSKETAKTVPAKKSIYSDDDEYEFQPNKKNFPDELKPGLNRVAKAVTKSEKLRERQFTPTPPSSDSESECRGKNRNRNVHKLYKRHDSDNRSEHKLQLKERIEPKKDDKEQRLVKLKEILKQRNGPKEIEEYRRRYLERKEKGVVIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1R9</accession>
    <name>A0A0D8Y1R9_DICVI</name>
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        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_03867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y1R9"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Casein kinase II subunit beta"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="280" mass="31395" checksum="A321E350A7E48373" modified="2015-05-27" version="1">MLSGLAGKPVNHGFLIAYTSLNDVPLNAGSASASATEQSAPSHEPGSETMSSSEEVSWITWFCGLRGNEFFCEEYIQDRFNLTGLNEQVPKYRQALDMILDLEPEDDMEDNSTNTDLVEQAAEMLYGLIHARYILTNRGIGMDNVNLSQMVEKWRDQDFGVCPRVYCESQAVLPIGLSDVPGEAMVKLYCPRCCDVFIPRSSRHLHTDGSYFGTGFPHMLFFVHPELRPRKPATQFVPRLYGFKIHPLAYNLQYQQSPQQANNGPPIEKVGQQFANAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1Y5</accession>
    <name>A0A0D8Y1Y5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clc-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1Y5"/>
    <dbReference type="OrthoDB" id="5803795at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21020" checksum="0005107E455F85DE" modified="2015-05-27" version="1">MTLASMSRVIFLVVSSLLTLISVTIITSCLFSVSFRYITDHEHLKGTRYYGLIRYCFESEFRTFGTEFELATLILLSCAVASSLMSIFFAIFTIFTVFGALAQCVMLLTAAICSISAFIVYTYFNELKDNQNETVNGNLIRYHFGWAYYWSGGASAGLFLAFICSLFASACVLLHNQQKKRINTILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y373</accession>
    <name>A0A0D8Y373_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </citation>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="187"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="204" mass="21758" checksum="46196F165A1573D5" modified="2015-05-27" version="1">MNPFSSCIPYLGSCLECIQGPSFSATTSYSQMTTLIPPSICLDTSRCGKDVVILKEGERICGTGAALGTLPIVQNKGYFQVNIQQGGVWGVGIGNLHSLLDEAPLIADFWGVRDNGDVVANGVVVGKLNIEISDGDCVGVCYDHVELNFLVNGQQAEPNITGVKGPAYPLVYVDDSAILDVKFRKFTVNPPVGYSEILAEQTIL</sequence>
</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716241">
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        <property type="entry name" value="bZIP"/>
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    </dbReference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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</entry>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="193"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="53378" checksum="F5B432F99D6E6D9D" modified="2015-05-27" version="1" fragment="single">VSSAWTFSFDGCNVTQSCWFHPPECDENNLGKCISGVQWSMVPDGIRIVLQTYVNDLDSIRPYYAALGFSYNQRMASKILKIEHKCCQTIYYASKIINRKIIDYKAKCLKASSVLLEDGNILLENGLLTCNMKLLLDKTSLISNETKFMIHDLEAQPYYLLFARGNADPWTLEKDIHSVNDNAQFPWITQKMVSFCRGDNCTSTSLYFLKDGIQSRVERYWRYRIAVLHGVALIVSWWVLGSSAILIARYFKPLFPRRKLLGTAIWFQLHRDIFIISVILQILAVIFIFWQAGWVWYQCSYRCTLQDFSKKMHAITGMIATVLAVLQPIFAFLRPSPDSKYRFIFNWGHWLIGMTAWSFATGSVSHSGATMLLSLPMGKTGLNSVYGYAPNWLMGGYILFFIGCNIVMEMLATSNEVRMEKNVSEIKPHRFIVGPSGMALSHLNGPAVESPLAPPIVSLIANHEKSIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5E7</accession>
    <name>A0A0D8Y5E7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5E7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5E7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF18">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="2">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="27363" checksum="E61ACD61D9FE02C8" modified="2015-05-27" version="1">MADDGLIFLCFARINKCSKVPLNAIIVFTILNAVIALVFDLSALVEFLSIGTLLAYSMVSACVLLLRHQAAPIENDPERLDCGGTLKTWVPFRNFWRVQPSGRSIFTAVFSLVIGYFWLALTFRLGMFSPILFYVSIALSSLLIIISFLFICGHEQNSLELNFKVPFVPFIPCLGLLVNVFMMSYLDYLTWIRFVVWMLIGLTIYFFYGIRHSKEGKKMFTVTESNVITAPNYAKKETTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5N6</accession>
    <name>A0A0D8Y5N6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5N6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5N6"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="49325" checksum="F9B11A244E37422E" modified="2015-05-27" version="1">MDRTASHLINNLKNLYYMRNKSTRNLAKSTESAVNTLVDSISKTDRDPRNTKKSGEMSFATQFILSTCMLANILSVRDSVDAPFELKVDNVRFAGHPKKLTTASEGSSTIFSIVFVLPANVDSNLVESFQLTTASEGSSTIFSIVFVLPANVDSNLVESFQLLSKKLALAIDSLQTQRGYFAEQERVMRSALDEFEAEVSALPESDQLAFDVPWESIRRRSALAELLTKVFIDVGRTGVVQVFVDNFIEVGFCVQSRAFTHAHLTPKNRAEIDKIVKKIRPYHGILLLEDVWPSPDANPSVTLLLKHCEPDRSILDISTASGIPLLQVFLIVRHLLLWARAVVIYPLCNTNVYSSATHPKPLERYISLFCQQFGSKFHLSDVLSQFDPPRSLGEYLNSRQPLFDQQNKAKVIVALLRHQLIMQRSGYHFKIETGGPFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y607</accession>
    <name>A0A0D8Y607_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_03879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH50006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y607"/>
    <dbReference type="STRING" id="29172.A0A0D8Y607"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH50006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="9416" checksum="1C6A2E60565D8D22" modified="2015-05-27" version="1">MSYTEYVQLQGTTITETLSDIGGNMGMFLGMSVITLVEVIMFFTKIVWITISKKRRDYMYKKKMFEKVKMRYNDEFFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6H2</accession>
    <name>A0A0D8Y6H2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6H2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6H2"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="37061" checksum="1F02C426F09A82E4" modified="2015-05-27" version="1">MPLELSQKSLDDTVSCFTTCDFIRPLEKTPVLISKFALMNENCCNRFSAPIQLTTLFHFRQLSCNGGDAHNRDSQPDSGDGEDQNHTRQIKQEIEDDVTSAGQDFFGKNYGIEKKVKHETDLDDASSTEFESNLKDRWCVSTRFGFGKNDDISVEEKEKVNLGVSGKLADDTNIFRGVLMKYNEPLKAKKPIFRLRLYPFKNNESLSVSHIHRESVCLIATVRKIADLPISHPICSTQHPVFQYRSIPFERIYGTEPRLVPPYTIHLSSSNGTFLNGSKNEPQRHVKLVNKDVLKSEFSRQEFVMFNKKLADGVNASDSQPYSPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Q2</accession>
    <name>A0A0D8Y6Q2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">5' exonuclease Apollo</fullName>
            <ecNumber evidence="5">3.5.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA cross-link repair 1B protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SNM1 homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_01946</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="5"/>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Q2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6Q2"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF26">
        <property type="entry name" value="5' EXONUCLEASE APOLLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="41898" checksum="7743976A04AF8EE2" modified="2015-05-27" version="1">MEHFKDLDEKWDVPVYCSETTAKILPVIMGKDAVSRRFLRPLRVGVTHSFEPNLYVTLLEANHCFGSVMILFEGAVIPGGAVLCTGSFRADTRLLSQFKSNSSFKKLKDTYISKLFLDNTYLDYTMSSFPERAESENILLKKMRKLRDCNILIPVSDFGSEEMLEKLSVNYSELISTSRKRLQIRKICGLKKGNFQMDNSNARIRTSQRHPCHVLTAFKEMEEPKMVIDLSLRNEYKKVIKQENLITIPYSDHSSRCEIIEFLSRLQFGELIPTGAPMNSSTAEELMKLSNKVVSDGPCETNSVYPSSQKIVFEPFSLQPANMSIFQVGDINLRRYAANRLDIKSANHSPMKTIEIKCYDKNGKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y721</accession>
    <name>A0A0D8Y721_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716207">
        <property type="protein sequence ID" value="KJH50376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y721"/>
    <dbReference type="OrthoDB" id="5858430at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336524" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15406" checksum="2BC8833B9E5AA06E" modified="2015-05-27" version="1">MNTAISVFLVLCVTRNLLNSSKLRVKRYTSRESVEERIEEGYQLLRSEPHAADTKAVLLQLHVMEKEIEGELALSSKQQADLLEDMKEYVDTVFDHVQPIGDIIPEINRHSNVDMALYQGDIMLTKFIRLSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Z2</accession>
    <name>A0A0D8Y7Z2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Torsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_03126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716199">
        <property type="protein sequence ID" value="KJH50686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7Z2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7Z2"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002276">
        <property type="entry name" value="Torsin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="8">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="429" mass="48907" checksum="A372E6A509A8133F" modified="2015-05-27" version="1">MASPVCLICKDLDNSNNTGEVHSIPCRLHFDGPAPVSGYFIQQEHENAKRWAVFRGHGLEGITLNLPSGYELYVLKKRADGVYDIESRRHSFLYWEWDREAGATVLFGGGVLWTFQNKIKCRLYECCDRPYVSPRFDNLHRDLHELVYGQHLVLDTVENSIRAHWTNERPKKPLVMSFHGFTGSGKNYVAEIIANNTFKNGMKSSFVHHIVATTDFPDSAKINEYKLKLRNKILEGVRKCSRALFIFDEADKLPEQLLEAIKPFLDYYDSVSGVDFRKSTFLFLSNRGGNVIANIILSHYQAGKPRDDLTLSNFERMLMQASYNEPGGLKFCDLISNHLVDHFVPFLPLERQHVILCAISYLKSQGRADLAADDELVQSIADSLQYFPREQEIFSSSGCKRIAAKADLEISKRILPSLAIRHLNLDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y875</accession>
    <name>A0A0D8Y875_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y875"/>
    <dbReference type="STRING" id="29172.A0A0D8Y875"/>
    <dbReference type="OrthoDB" id="5911973at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36520:SF4">
        <property type="entry name" value="DUF3421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36520">
        <property type="entry name" value="PROTEIN CBG13000-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336296" evidence="2">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="32397" checksum="1AA1F51BD93BBB5D" modified="2015-05-27" version="1">MYSTVYVILFLIDNVYGQKYGSDEPLVVPLSGTLAQFPALITADNFPLFPFTDQFSTGVEINPANKVSVAGDLNIPVPGWGNFDVDGNIYFGHINVDAKAGYQIRPTNKLGIKPETLALLGQNPEFRLARKQAKELVVGRIPYGYEPIKCKPPYCNPFVHHAGAAVEVEQGDDWFFIGGIDFPLPIGPLGSGVRFPLSGAVEAGTSPYAYAHGNAFNPVSPFDLKAINDEDITQTIGLGIDSICTDLISILSQANILPSIYIFHAFSTNNVLSFSVSFFLLLFSKRKLLLMSLDIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8N4</accession>
    <name>A0A0D8Y8N4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8N4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8N4"/>
    <dbReference type="OrthoDB" id="5836615at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="28383" checksum="D5328EB6319EC046" modified="2015-05-27" version="1">MTEDDHQESDGERELSDSDSELDLDISDYEKRREHCLRQIILSEIQFNKLKNILKDLKIRQLVKRREDVINQTDPEFMAKHRELLEEFDARNKLTEAIRCLEMDSLERRTLGLKKIAQTNQDDNKIITQEKIREQIINEIRAEKQREIETKIVKSYFLAKRLELKRDRSDVNLDFHVKKARFNIPVIIHQLTEHQIEADIRSAELAILIADIKKESEDILHSAIQLWAASDGEFRASRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9T2</accession>
    <name>A0A0D8Y9T2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9T2"/>
    <dbReference type="OrthoDB" id="5801335at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF13">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
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            <end position="106"/>
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        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="24258" checksum="564E403249E333DE" modified="2015-05-27" version="1">MPIQIPKSQPQHRHHRVDALWDSNADKYRVACRSVHVMRATQFIGYGQLLVIGLFTFALLFFYGKHLNGGLPEDHWLASAGGRYITSLLTAVSLQLSLVLMMLHGVRSQRRSFLLPFIIFASFAVFLAFIQVSSDLVAASQSRIGASSGPALLSHVIGMCVHVWCVAVVWRCYCYLGDKKVAEQIGEQLQVTSLAFAYDYTQPPPYVDTIEKSPLTVA</sequence>
</entry>
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    </gene>
    <organism evidence="4 5">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="362" mass="40059" checksum="6A3CE167C7E92114" modified="2015-05-27" version="1">MVCLKRFQSTSGVMVNPDVQATFQKLSEGKKEFRYIIFKIEEREVVVEAAVTQEELGLTGDDYDDSSKAAFEKFVADIKARTDGFTDCRYAVFDFKFTCSRVGAGTSKMDKIVFLQLCPDGASIKKKMVYASSASAIKASLGTGKILQFQVCVGRVGNVTQRIAVKADRKIRGQLSFSGGLDVFDPPVSETRIIRECVLRVALCITTTVLYASGVKIDPSCKNAYDMLHNKHQHSYIIFKIDKNDTAIVVEKVGDKGAPYSEFIEEMKKAVDGGKECRYAAVDVEVQVQRQGTEGGSKLNKVIFVQYCPDQAPVRRRMLYASSVRALKATLGLESLMQVQASDLSDLDEKAIKHDLVSSQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9V9</accession>
    <name>A0A0D8Y9V9_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_02470</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
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    </dbReference>
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        <property type="entry name" value="N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="17293" checksum="9C32896A2E14B3AC" modified="2015-05-27" version="1">MEFLTRFRTPVGFLLREVLSSSTSYTDALHVLSTRHLFSPSYIIIAGREKNEGAIISRDRMRAADVIKLSDRRWYLVETNYDHWRKDMDKRRITAVKMLKTLGRDNLNVNTMMDVLTTFPVKNNLTLFSTVMSAHYPSLIKKTTFIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9X2</accession>
    <name>A0A0D8Y9X2_DICVI</name>
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        <submittedName>
            <fullName evidence="2">BTB/POZ domain protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_00295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y9X2"/>
    <dbReference type="OrthoDB" id="5809990at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="211"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="375" mass="43166" checksum="B7D2E47693EEA24F" modified="2015-05-27" version="1">MITLTPHQEVSRNPISTEIDKPTLAAVQSDAISTSYKSTRHSSYSDLPKIRQLHLNTIFRQDVDDQQWSDPNTMSKIETSIIAGGVEWMFKLQKLMSEGSSHLGFTIVCGAKLRSTLWRINANIKLIVREKDCEKFVERYYPSSEFMFACRTLADMIPWEEINTDLSLSNRPDTKSPIVLTFELEIDITKSYGFRRRAEYEYSFYEPSLETDMVLVIENKHLFVNATYLSMLSPFFRSLKASPSHDSYEEIQKETIMDVSVEEFLVLLHAVYPSQRPVTVDNVETLLKLADRYCFECILIKCEDFLISPPADEIDIFKRLEWASNYAMADLQDHCVSKLNDVSDVAAVKKTLLYGNLSHETRKLLLDLMLKFSNA</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Z4"/>
    <dbReference type="OrthoDB" id="5860189at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="27883" checksum="C0E4034C1ABD8815" modified="2015-05-27" version="1">MGPAENVHNIVNGLIRHTILDVERVLKRIPQNGDHLDVISMPDNKAFNEVDISLDKIVLKRIPQNGDHLDVISMPDNKAFNEVDISLDKIEEILPSSCSDTLGVVRSSSVSYVSKSKHEEQENTVKMSNRNEKKKFVKATAHILSDTLFRSSVSSVSKSKHEEQENTVKMSNRNEKKKFVKATAHILSDTIRVLPIGKMDGMKLDMMLRLNKKNPDETQLIDIRIECPEFKPNRIRVDGQWYNIV</sequence>
</entry>
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    <name>A0A0D8YA03_DICVI</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA03"/>
    <dbReference type="OrthoDB" id="5868180at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19651" checksum="AABA21F16E9106A3" modified="2015-05-27" version="1">MCVRKKTRRSAKENLKTGSIASTPKSCTPRGDREKQKTTKKKQQTKTENEDSKDAKEEKITHETKTTQNTKGAKTKDIKEVKDNSENIVAKPLKNAPPAVEEKKKEPLHIKVPPPRVMKAKRPMKEVRSARDPEYKTLELDISEWESVKILKRSELNPDDFNKKDSKVDSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAA5</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAA5"/>
    <dbReference type="OrthoDB" id="5778782at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="71" mass="8531" checksum="3244259B00679175" modified="2015-05-27" version="1">MNPDKTYGVYFDEENKLHYYNCAPIKQKRRKRRSLPNPLRKFFSRLFDRQNSTTCAQISDPELSVQSDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAK5</accession>
    <name>A0A0D8YAK5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAK5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9962" checksum="BF0F0361397E45E9" modified="2015-05-27" version="1">MTSMEQNRFDLNIRIVLNQVLHYAHVLVLIPLDRMLCSVDEHVRCCCSPFITSSKSSSSCSQLLKISNKCLLIDLTRYHESLFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAN6</accession>
    <name>A0A0D8YAN6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuralized</fullName>
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        <name evidence="2" type="ORF">DICVIV_00543</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YAN6"/>
    <dbReference type="OrthoDB" id="10059069at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
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    </evidence>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    <sequence length="351" mass="40474" checksum="71E0BC141207BCDB" modified="2015-05-27" version="1">MNMHCVGETDHVVESDFKDTGQTEEQLESTHQSQSAKRKMMSQEKIYELVKMRDKLLKHLEKLEGREVTFDDEAKEQFYINNELKEAEIFQIRKSILDIEKLLYNGDVLTELDDELRIFHSNKCQAELLVLDTGNRILNEELQHFMIMRSNKKCVTPSFDELNSIMRDVRKQEGESSDIPDPELDPQAFLDRLENVAFLVARAHQKLISGEFLEDLDLYVPKRERPQCSKYPMTNIEFRNQPAKDEVTSVSDETFLMAIRSAGKLELNSTATLSCDEEIEILSDDSSCVDDEEDILGMACDDVEVENKSTRSEGESECGVTTSTPYHLEEQDLKNRNEMDCKDVDVIYIDD</sequence>
</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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    </evidence>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="190" mass="21104" checksum="820FB3F42EFC59DD" modified="2015-05-27" version="1">MKALQTEAGQNSTKSDVPLVVDALNKSSTTSSNSENAQSSKHHMFVEGNKLQLNAKAVMIGDTYFDLFCDLLITQERIRFSVLRKIDVETAIVVAYIKIKNVVDALYNDGDENKFLGLVLDDDGQKGLPSQLQVYSSTKYWHLMFHLLVGGNVEEDVKSKLEGFFESKIKIGSSPLTLLSPMKTELNVTI</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717460">
        <property type="protein sequence ID" value="KJH40250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6T8"/>
    <dbReference type="STRING" id="29172.A0A0D8X6T8"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13472" checksum="DFB877115899ECD7" modified="2015-05-27" version="1">MVTLLAKGLGAFQETLEPLVQACHLLQMIAILQHYAPSDDFEERDVDADLLMMIQRRLNQRANANGVNAEDQNTLIVMGTYLQPFDCHCFVHSDFPLQTLLLPTCLHLQQFCSGWAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X735</accession>
    <name>A0A0D8X735_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LLGL2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717372">
        <property type="protein sequence ID" value="KJH40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X735"/>
    <dbReference type="STRING" id="29172.A0A0D8X735"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="3">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112686" checksum="91F8D290EC164551" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7B3</accession>
    <name>A0A0D8X7B3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717236">
        <property type="protein sequence ID" value="KJH40418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7B3"/>
    <dbReference type="STRING" id="29172.A0A0D8X7B3"/>
    <dbReference type="OrthoDB" id="5848454at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335561" evidence="1">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="15537" checksum="F13ECCA8F4B24A78" modified="2015-05-27" version="1">MMMCKMGRLAIFTYCTLLFPIFSTYTLPPTGIISPSDDSDANIFDHWVPRCLDHKIHLPKNKMVRVLKFHTKGLRRLEIDAMIRQCFQTLCKDWMSECHWYCDAVKNDNHLRRCKDCLSWRGQQCIDCFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7F5</accession>
    <name>A0A0D8X7F5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M1 membrane alanine aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717175">
        <property type="protein sequence ID" value="KJH40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7F5"/>
    <dbReference type="STRING" id="29172.A0A0D8X7F5"/>
    <dbReference type="MEROPS" id="M01.A20"/>
    <dbReference type="OrthoDB" id="8182982at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF257">
        <property type="entry name" value="PEPTIDASE_M1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="16809" checksum="61582281A4C52E24" modified="2015-05-27" version="1" fragment="single">LSRKTSFGVTVNVYATSHAISRRVLNIAIASFELLNSIMEIPLSLNKVDFVILSNYDGGMGNWGHVLLSEDLAISEDEAHLSYVIARELVYQWIGDKSTIDSWQWICLQRIKLTTILEFRVKALHQTAEIQKLDGARSFRGITLSSYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7R4</accession>
    <name>A0A0D8X7R4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="119" mass="13869" checksum="A3E55707EF893BDF" modified="2015-05-27" version="1" fragment="single">MFFRYANINVTRGIFSTLKCCTKPCHPEVTNPTMLALHELYRQETATTCEKGYSLLRNGRLNKGLTFTLEERQYLGIHGLLPPTFMTEEQQGYRIMTYLRKLPDNLFKGITKEVSPIRY</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717466">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5812404at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="158" mass="17904" checksum="9119C7EFA7B228C2" modified="2015-05-27" version="1">MHPALQTRVKSTLVAKDNYRSHHGRKTTLRKSLRLGNEPCMYLPAMLKCTKCGEEIGSGLTFNTVLSHVQKAHLKIAAFQCRICKHYRTTHERIQSHVTTVHKARSTKFDSSLAGPISTKDMQLMEKMISICFPGVRVKLEITDRLSIGMFEYNGVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X992</accession>
    <name>A0A0D8X992_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_13738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH40322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9S0</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717152">
        <property type="protein sequence ID" value="KJH40517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5850569at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="14105" checksum="A293589949734869" modified="2015-05-27" version="1">MSNQHYNVAPVVNSFGGSLLMALVDSNPTFKCVVESSLESLKGIVHSWWKTALEGGDLVGLAPSLQNGPMIPFLEMANGKTNRLGCAYHLCSGDSDDDEEEEEQSFLFVCKYGEDLNRFLKMPNNDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA69</accession>
    <name>A0A0D8XA69_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EMBL" id="KN717140">
        <property type="protein sequence ID" value="KJH40529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA69"/>
    <dbReference type="STRING" id="29172.A0A0D8XA69"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="30228" checksum="831F37BBE0B8B1B8" modified="2015-05-27" version="1">MWHHGTITVCHSKTQQIKEHCLNADILVVAIGKKHFVKGDWIKPGAVVIDCGINVEETPQQGKKVNCLEMWNLKQQKRLLGTSHRSLVSDVGSWNMECLPLTYSVPVPSDITISRSQTPKDIEQLAREIGVLPEEIDPYGRKKAKVSLNVLKRLQHVNDGKYIVVAGITPTPLGEGKSTTTIGLVQSLGAHLKKNAFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLLAAAIDARMFHEATQKDEALFNRLCPMNEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAH0</accession>
    <name>A0A0D8XAH0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716791">
        <property type="protein sequence ID" value="KJH41600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAH0"/>
    <dbReference type="STRING" id="29172.A0A0D8XAH0"/>
    <dbReference type="OrthoDB" id="5853768at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36935">
        <property type="entry name" value="PROTEIN CBG00261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36935:SF1">
        <property type="entry name" value="RAS FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23668" checksum="A5D70EF130388343" modified="2015-05-27" version="1">MLEFTDPGLSRTGGREMAIKRADLALLFYSALSLSSLHHLQTLKEDLEMKIHMPLRLVCDIDEVIEDEEDGGSTGISSVSEGYESDTDRDSRIRRHNSMEKFRKTNEEGGIAIEQGQKWANELGSECEFIVLSSSQFTDANTFLENIINSIHKYRKRNMRTFLKHLKSRSKSSTQKLDKTRDSRESTKSSISSSYSDIENKSKVCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAK4</accession>
    <name>A0A0D8XAK4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_13259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717017">
        <property type="protein sequence ID" value="KJH40777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAK4"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF53">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="22"/>
            <end position="181"/>
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        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
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            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="181" mass="20472" checksum="551551842AB0C8A5" modified="2015-05-27" version="1">MLNIWVLLATIHCTTSPTTIAAATTGVSGIIDPRCTVPSKGALKFSHEAVNCDNELSDDECRMFYSIEVKENDDKDRDKKCYEKVTDAYIACSAVTREMCKDPMWKPILVENCPKTCGFCRETNAVTIGFEIIFAIIHYILLLRKNSFVANSAICAANIRQRLRYDIPSPSITVYQQYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC29</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="323" mass="36886" checksum="473A236BC8B9E95E" modified="2015-05-27" version="1">MGTISMYYSHVFIGISSTLILSNCAKRQKLDSETNQPQKSGSATPASEHALPKTSASSTSSTDRVIRNEITAKSNPSNWNPFSKESQVTAPVLGETTMKPSISARNYEELCIIIVYSLQINKTQNTYDDAPQNKPQQRRMFVFEPISYLSSEKRQPSQDDETIHDAPSLAKINEDVGSEDQPSAKKISSQHFNYKNEMITQKYPEFSEEIHMKPNQSTNITLSKSTRKTSKDTELAKTESYKRNQQTVTNYDQFNRLQATMKENYRYQPAIIFVLRWLYILAKNMVRINTIEGNDQARFLHSNSAIDSIMFNKSYINTNVLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC78</accession>
    <name>A0A0D8XC78_DICVI</name>
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        <submittedName>
            <fullName evidence="2">START domain protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716695">
        <property type="protein sequence ID" value="KJH42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XC78"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:cholesterol binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:cholesterol transfer activity"/>
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="282" mass="31424" checksum="D11D830DAC85BBC6" modified="2015-05-27" version="1">MEKLCLYYCAMFIFAPTVSLAMTSVTLHGVTDKLSPPYEKYTSALETAAAAFREVEALFNDRSFVEKVGWKVDEKNDQGDVVYAKVTPKGKMVSISTELPLDVDSVMNETWTGVERLPEWNPSINFARTVASPTPNFDIITYGNNDVLVVSGRDFVSARIYRKTSSGYILASRSVRLKEVPEQKGRRSLTSIRGILGDKMFVKHFRSAVIETELLLAGARFTRHPQKADVTSTDVVMQADLKGLLPKFVVNKASVLYWARSCSQTQRKTGVISMTSKIDEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCD5</accession>
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    <organism evidence="2 3">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="19410" checksum="6EBECC8630090A33" modified="2015-05-27" version="1" fragment="single">MRGNPIWFQLQDSESPRIRRKQTAIKICVQTLNAVRDLHDIGFLHRDLKLANFAIGIDKPSHETIFMLDFGIAKRIAGDDGIIPEPREKVAFMGTRRYASRACHQMKEQGRKDDVESWRYMVLDIFDEKCIPWRELKENDETFRMKDDLMHSRDDLFTDGDLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDQ5</accession>
    <name>A0A0D8XDQ5_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12117</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716740">
        <property type="protein sequence ID" value="KJH41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XDQ5"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="VWF_A"/>
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    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="15748" checksum="E86F2D57C2ECF5BA" modified="2015-05-27" version="1">MLHHATYFLRDVLYGLMTYANKRQQRLNVPIDLRIPKKLFLKKLAKARFLSGVTATGAALRAVAALQFLRKTDIIVVTDGFTFDTVGVEAQKLRKLPNIRVLVVGNYSPVVKKVLDDIAGDSNNVLLGNQSVQRLLNLLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDS3</accession>
    <name>A0A0D8XDS3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717097">
        <property type="protein sequence ID" value="KJH40591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDS3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDS3"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13883" checksum="484F096740C17CC9" modified="2015-05-27" version="1">MFYFQVTLMRHFKYSLENLMLLHFLFTCGWKCTKVLDMLIRCSIMTFWISISIRARIKQSAKDLEGQLYEDLLFDYNKIPRPVKNSSDILTVDVGASLIRIIDVVCFHVLFCFLANLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDU2</accession>
    <name>A0A0D8XDU2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716735">
        <property type="protein sequence ID" value="KJH41937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDU2"/>
    <dbReference type="STRING" id="29172.A0A0D8XDU2"/>
    <dbReference type="OrthoDB" id="5824679at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="15423" checksum="C64A5EC35986CEC8" modified="2015-05-27" version="1">MTTQYSHKVIRFIIHLETALNEHFEYISSFNFTFTKNIYYRSEMNRAILSLRHHVPLMRRAMHKGFESTPPMRFTSMTENVVLYLLIAGTFLSYPSYVLANLDNIRPKPQTALNPKVQAQIEEIRASRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE88</accession>
    <name>A0A0D8XE88_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716713">
        <property type="protein sequence ID" value="KJH42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE88"/>
    <dbReference type="OrthoDB" id="5875734at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="102" mass="11601" checksum="954747C86A6A6135" modified="2015-05-27" version="1">MSIWNNIGFYICKVIAAPAQGLWVACLITGIGSFTIYYALFHATTFLYNYEEEAKTLRQKKNFQFTLSPPAEENEIEVSQISHLIGQLVSYFGKLTLLTNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEJ3</accession>
    <name>A0A0D8XEJ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716996">
        <property type="protein sequence ID" value="KJH40841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEJ3"/>
    <dbReference type="STRING" id="29172.A0A0D8XEJ3"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="193"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="510"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="726" mass="82524" checksum="EEC48A672AC68947" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEN7</accession>
    <name>A0A0D8XEN7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Asc-type amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_13144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716981">
        <property type="protein sequence ID" value="KJH40891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEN7"/>
    <dbReference type="STRING" id="29172.A0A0D8XEN7"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH40891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="53583" checksum="E5866B352A26F236" modified="2015-05-27" version="1">MASVETEPLKPADRLKDVDDGRGLAKSLTLFNGVSIIVGCIIGSGIFVSPTGVQEKAGSVGLSLIVWVLCGVFAGIGAYCYAELGTLIHKSGGDYAYIMEAFGSFLAFVRLWIESIVVRPCTATIVALTFAIYMLRPFYPECDPPAGSIQLLAASLLVLLTAINSISVRLATFVQDFFTVAKVFALLMIIVTGAILLLTGKPQYYESFENIFENTARDFKTASLAFYSGLFAYQGWNYLNFIVEELQNPRRNLPLAIAISCTTVTIIYTLTNIALYTVISPDEMLASPAVAVLFAEKMYGSFAFIMPIFVACSTIGSANGVIFTSSRLFFVGAREGHMPQILTMINKSTRTPIPAVVFTGILSLAYLTLSDNIFSLINYIQISYWLAIGAATAALFWLRKTMPDATRPIKVNLIFPVLFFLGCCALVFIPIVGAPKDTAIGLLIMLTGVPIYLVFIAWKSKPHCIDTITTSFTVFCQKLFMVVDDNKQNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEP2</accession>
    <name>A0A0D8XEP2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716704">
        <property type="protein sequence ID" value="KJH42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEP2"/>
    <dbReference type="STRING" id="29172.A0A0D8XEP2"/>
    <dbReference type="OrthoDB" id="5775694at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335618" evidence="1">
        <location>
            <begin position="30"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="47"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="25663" checksum="975971C69A63BF68" modified="2015-05-27" version="1">MTPMVDHLHSMKTIATVIFFITILQNSICQGNDPGPHCNGESRMTPFNRRDFLQGHNFKRVLLAGGNFRVSFPPAGNMNYLTYNCDLEQAAHEIASACHLYDYYDFNYVGNNSAKFEGPYFDINFITDAVNQWWDLGKKYSNLENLTPSEDNSPMIPFLQMANGETAELGCSYNLCESTDDDSSSFFLLVCKYGKPYIETGKAIYTEGKACNSCGGKCVWSMLCDNTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHF8</accession>
    <name>A0A0D8XHF8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_10817</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="KN716585">
        <property type="protein sequence ID" value="KJH43167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHF8"/>
    <dbReference type="STRING" id="29172.A0A0D8XHF8"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="429" mass="48128" checksum="D21A459D2985B52B" modified="2015-05-27" version="1">MSEAWVTLATNDGYAQGALVLAHSLKASETTKKLHCMVTNQVSARLRSELEAQFDEVSHVDVLDSNDHENLALINRPDLGVTFTKLQCWRLVQYNKAVFLDADTMVLKNADELFERPEFSAAPDIGWPDCFNSGVFVYVPNIETYRRLLEFALSHGSFDGGDQGLLNEFFAGWRDLPAIHRLPFIYNMTAGIFYSYAAAFKRYGASTKIVHFIGSDKPWHGSTAAAQSEHLEKWKQIHQSNVAAYTASTYSSTRQTSSLPSSPSKDDVLSFPTYTLVSDADYTGSSYKQSLDNEYYQETLSKSNESTYEYVTQNLGFSSVYWPEVCVAVESHAFVDSQNLRNDDETRHSTTEEIDETILFAVFDLLVCVLALTDRLQAEACFSPGCLRDKAPSPTDEDRLRAWESGQPDFMGRDAFVNIQAALDRALQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHI9</accession>
    <name>A0A0D8XHI9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716501">
        <property type="protein sequence ID" value="KJH44083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHI9"/>
    <dbReference type="STRING" id="29172.A0A0D8XHI9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335843" evidence="1">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="28135" checksum="9A158B8601B25816" modified="2015-05-27" version="1">MSGTLKRHLKMDVTLVVQLLLWQALLRHMNQHQDCNVHFECRNSWYPLAVVNLVVGWDPLNFAVGWDALNFVVGWDALNFVVGWDALNFVVSWDALNFVVGWDPLNFVVVLRNSLVSKKNFIQQYSRLNEVGPRRNFSYCAVQLCERERREVTCRQGSRMRGKGHAKAGTRRYVASGAVDGALSAIEHFNALSKRGTKGFKKMEWKVSPFEEELVKASVVELNKNISKDVDFVEGIGVNMWFFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XII4</accession>
    <name>A0A0D8XII4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716705">
        <property type="protein sequence ID" value="KJH42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XII4"/>
    <dbReference type="OrthoDB" id="447368at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="150" mass="17891" checksum="5B2C8C4FD85A0FBD" modified="2015-05-27" version="1">MESVDEEIKLNSFALGANKLTTIRHKAKQISPQLIRAQRIEKKLTINRQKRLINRLKKQYIIEQKNYREFTKSELKKERSQRRLRTIMELMDKLTTERKKKTQVGMVFQRPRPFRTSIFENVAYSLKCHGIRDQELTKCLVKEALMDVAL</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF12">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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            <begin position="44"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="29172.A0A0D8XJ01"/>
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        <property type="entry name" value="PROTEIN CBG02620"/>
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    </dbReference>
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        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="14932" checksum="8A02F68C42EAB1D0" modified="2015-05-27" version="1">MADGFWLFDGLDEEPYGLLPLVNLAGKGGPTSTKYVDRMGSYQWLLTDDTPTILVPGMPAESFFWPGGKLPQDHGVVIYDVNHLKVPAGSLDAVIISTKLLADKKRKPIDFSQYHFITDAVNLQKLFAFCQVCVV</sequence>
</entry>
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    <accession>A0A0D8XJ78</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="25"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="200" mass="22608" checksum="0A98B463B55F5A33" modified="2015-05-27" version="1">MKFASEEQKRQQQIKSLYDMTAQTEKMRAKNKIEAEQKARARREKLNALRRRKGLPEERTPSPEPEPEIPEFQLNEIPLPIEQPLEMAPLERSPTPNVPWHQLVAHARLLRTEIRSSLTLPFSRMSIVSTENGCKLYALGTPSCASNQTVLAAQIPLNDVVSNIVMEPMFSIDQFKVMTGTLSGSALCDTYPLFCLSLTI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="21"/>
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        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    <comment type="similarity">
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
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        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32148" checksum="EF51D9F77BEFA41E" modified="2015-05-27" version="1">MATGLQHRNPFDSTTVSILDPILNHDMTRQVADSIIPVNVAWSSEDDGNSVRFEWSEYMTLAGKAIKASPLINDPMSAVVVGMLVTVILQSATTTTNILVGMIAANSFIEEVSWLIVDPLIAEHGISLKTLDLLTDPINRMIIEVNEVELRNATIDDDYFPPNHSFVSRIRLISAHLLHRSLQTHFCIIFIIGRRNRMDRSLLNGPTASCVRILLAKKCPGIWKPCTGYAVMLAGLLITLAIQSNSMFSSSLTPLVGSGVITLDQMYPLILGANIGGSFSAVLAALTADGSRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNN2</accession>
    <name>A0A0D8XNN2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNN2"/>
    <dbReference type="STRING" id="29172.A0A0D8XNN2"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
    </dbReference>
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        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF15">
        <property type="entry name" value="SRC-LIKE-ADAPTER 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23795" checksum="494D571521884A25" modified="2015-05-27" version="1">MGGCVGKSVKKPSNSNIKLKPHELLMNSTQHNVNYQFLFVVLEILSDMQGDWWFARHKATGKTGYIPSNYVAKEKSIESQPWYFGKVRRVDAEKALLQPENQNGSFMVRESESRQNDLSLSIREDDCVKHYRIRQMDQGGYFIARRRPFRTLQDLITHYINDADGLCVRLTKACVKFDAPETSTFTYVSGAIKKTILTTQTELTFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPV4</accession>
    <name>A0A0D8XPV4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716388">
        <property type="protein sequence ID" value="KJH45762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPV4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10358" checksum="8064C12BC0F4D85F" modified="2015-05-27" version="1">MLESLINWFTNGLGKINGFGHKINKIPRHKINLGTNDPHHVAVLRTPKYQCILAFTFDLLHKLTADSSIDFHASGAPYGNHLKELTTFEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR26</accession>
    <name>A0A0D8XR26_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydropyridine sensitive L-type calcium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calcium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716364">
        <property type="protein sequence ID" value="KJH46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR26"/>
    <dbReference type="STRING" id="29172.A0A0D8XR26"/>
    <dbReference type="OrthoDB" id="5962384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11863">
        <property type="entry name" value="SH3_CACNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000023">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046937">
        <property type="entry name" value="CAB1-4_N_A-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12052">
        <property type="entry name" value="VGCC_beta4Aa_N"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    <sequence length="313" mass="35694" checksum="618369B3FC4F4C9F" modified="2015-05-27" version="1">MAHNFRKNLISKCIRDCGTGEFDADLLNEVINGTSDIDIVRLRTYAWRHTIPSMHRVQMYKYMLGISGAYPETRGIVEQHRRDEVSYRKPLFIQIFDQHGRALVLLRCLKTTRSTDYRNDGKSAEPEPTSSDVVKMILLASNHLSKAFAQSLQYIVISAIVRQVWIVCRCDWVDRFCIARSVYSIISEMFDERTIYQEVNGLDTSLKQIAAIDVEIWLKTGCCALLRSERAMQRVMDKLCTGINIVPLAKAIASDYLQSADNYLGHGLMDPGIITMTEDGELRMVNKAIESVLYDTMQKKPARVSENKSRSHS</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="10">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="9">
        <location>
            <begin position="215"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="401" mass="45663" checksum="E6E6FF760B187117" modified="2015-05-27" version="1">MSNVFRSQVSDVDLGRVMGICRCLNLSFTEEQVLAIIAVIEAGAYPSSLVEWLRKMEESKVAEMIWMFSSFMSFFNRLRDFDAYTKPMDDFRVKTFTGGMVSVISTAVIILLAIQETMHYLRGDIVEQLYVDSTSSDVRLDVHFDVTFHRLPCAFITVDVMDVSSENQDNIQDDIFKLRLDSSGNKISDDVQRIEVNQNKTSDALAMVTPECGSCYGALPNGSCCNTCDQVKEAYQLRGWQINVEVVEQCKEDSWVEKLKSFKGEGCQVYGKLQVAKVAGNFHFAPGDAHRIMRAHIHDFHSLDLSHFDTGHRINHLSFGDEYPGKQYPLNGKNFDEIKGPLMHNYYVKVVPTSYVYIDGRVENSHQFSVTIHQKDIRKGITGFFSVYFIFPPLYLYLVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSP2</accession>
    <name>A0A0D8XSP2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716334">
        <property type="protein sequence ID" value="KJH46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSP2"/>
    <dbReference type="STRING" id="29172.A0A0D8XSP2"/>
    <dbReference type="OrthoDB" id="10067217at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="30853" checksum="D9658769CD8DBB48" modified="2015-05-27" version="1">MHTPPAIYTLDAASDTNLIWSGPSRPELAIPHPVQLSRMGGSTFDSEQLMMKRNEIINRLAPLTLLDDDDLEDGVGHVSYTVASSVLDDRGELHPVTVVASPQTRGLPHISTTNLSSVQMSATTAEGPINVTVESSLSKSCHRAPGVTLMQLTSAVTARETSLLSSESPPLATVQSDCSIMQVKDSLNQSLPTPAVQRSQAPLPLCAVPLVFDSNIIRERIGVSSTGINQQLVAELRIPQREMNRLDQTLVHRLYVYFVSFVRWIGKLSKSKLLIHLERRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSS8</accession>
    <name>A0A0D8XSS8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_07047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSS8"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="238" mass="25782" checksum="1B9559CE9D7FFCA3" modified="2015-05-27" version="1">MAPYSVLVTGANRGIGLGLVKGFLKDKDIQHELNEINDKRLSIIKLDVTDDDSIRDTYAAVQKLLGDRGLTVLINNAGIYVKYSTNQTPNRADIIKNFDTNVAAVAVLTQVFLPLLRKAAAHAPLDEFSIDRAAIINISSAAGSISNNTTGSSTGGMLAYRLSKSALNSLTKTMAIDLESEHILVSSFCPGWVQTDMGGPDAQITIEESVEALVSSFSELEKKHHGGYFRRDLEPIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTA7</accession>
    <name>A0A0D8XTA7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716397">
        <property type="protein sequence ID" value="KJH45616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTA7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="69" mass="8142" checksum="F76DD2FB5D37CF14" modified="2015-05-27" version="1" fragment="single">MNAFLMVTAKCEREFMELFHRGMRILLLTALTDDLMKRRHFYFTSSLKVSLQSLISKINLILLIKYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTF5</accession>
    <name>A0A0D8XTF5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716394">
        <property type="protein sequence ID" value="KJH45661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTF5"/>
    <dbReference type="STRING" id="29172.A0A0D8XTF5"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KJH45661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="801" mass="88606" checksum="27C2816F98315C81" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTK3</accession>
    <name>A0A0D8XTK3_DICVI</name>
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        <submittedName>
            <fullName evidence="7">A-macroglobulin complement component</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">DICVIV_06086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TEP (THIOLESTER CONTAINING PROTEIN)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="40"/>
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        </location>
    </feature>
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        <location>
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            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="837" mass="92805" checksum="27F62D532BEC7F08" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTN8</accession>
    <name>A0A0D8XTN8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTN8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8737" checksum="F38BCEB004E8D4A2" modified="2015-05-27" version="1">MVEFKAYNFLRTTKSLCLFCAALYTRYSNGFLPSNLLVLMYGCEDFDWYHTRGRKFTLIILGFDDIIVYGWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUV9</accession>
    <name>A0A0D8XUV9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XUV9"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16490" checksum="10315F7E9191AF6F" modified="2015-05-27" version="1">MEVARDHLEKQLHCTVIEGLLSPVADSFNKPNLASSHHRLAMLEAATLNSRWLRADGWECKQKSWSPTLSVLKHHHQETRKKLQCDLRLALVVGADVVESFTRILPSGEYLWHPDDIYEIITKFGLIVIRREGADPYQSSEIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV21</accession>
    <name>A0A0D8XV21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:sulfate symporter transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XV21"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF85">
        <property type="entry name" value="SODIUM-DEPENDENT HIGH-AFFINITY DICARBOXYLATE TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="100"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="37378" checksum="4B143C2B4DF4AC11" modified="2015-05-27" version="1">MYWMTEALPLAVTAMVPVVLYPLTGVMTCKAVAQQYVNDTNFLFIGGLIVAVAIEKCNLHKRIALFILKLVGSDPKWIMLGLMLGTCSLRSEDLKKSCKEMSTGLALCICYASSIGGTGTLTGTPGNLVLAGQLPELFDSRATLDYVNWFLFSFPLMVFCLAACWGTLVHSEWTVAISFVVLLLLWILRDPGLFPGFGTFLPKKNYTDATSAMIIALLLFALPNDKPDFCDYKKKNAKESPRCMDWPTIQKRFPWDVVLLLGGGFALASGVKDSGLAKMIGGLLSSSSFLPLWVLELVTMSITLGVTNFCSNVATTTIFVPIVATLLSNILESHETMFIFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVQ7</accession>
    <name>A0A0D8XVQ7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XVQ7"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="IML1"/>
    </dbReference>
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        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="708" mass="81308" checksum="9326459E044111FC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVY5</accession>
    <name>A0A0D8XVY5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
    <sequence length="405" mass="46152" checksum="72857FF3E4A833EF" modified="2015-05-27" version="1">MYRLESVHKNPTVGALLGNSALGVEIFLVLSGFLGGRSWLKRADQPFFAHYRAFIIRRVLRLTPSVIFFIYIATSSLSKHLLPRFHSSMISSCSMSSIASHLIFLGNWQSTPTCLGYLWYLGLDFQLYMLAPFLLYSLYEWPLFGKILCAFLIIASMILRAGYCTVYNICHKSDVDIPFIAFPGQEESDIREIYAGIWEMYARPYTKCGPFILGLLLGTATISMKPFLTVRTSRLIASTFFALCISVVYAILPQYWYGNYFKQYNMYYTASFRTIFAIGICGMILAIISQQTSKSTSFMWSLLARLTYNTYLLHMPVIYLFNYSQFLQQAKTASELMMVVPFVAILCFIVSSIFYIFVEAPLGRLTSSWADQIEAVLVSSIGSLRYFIVSVPIRRLLKYYACTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY36</accession>
    <name>A0A0D8XY36_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY36"/>
    <dbReference type="STRING" id="29172.A0A0D8XY36"/>
    <dbReference type="OrthoDB" id="5870622at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF298">
        <property type="entry name" value="CUTICLE COLLAGEN 75-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="299" mass="31273" checksum="7E8974126D37F59F" modified="2015-05-27" version="1">MKGDMSDITETVPYQASSIYHYEESEEAEGEEVKDDLSTSLSDYNSLISSNQMVVISRSCCFHFVDRKFYEELPKSNRCPQGDKGPPGLKGESGYPGIPGKPGYDGKPFFYSQPIFTSAFPKDSRNTPCSPCPAGPPGMPGTKGLQGYPGNPGLPGIPGTPGQHGKPGPVGPPGERGRRGRPGPSGQRGPRGSDGILGGKGSPGLPGLPVPGPQGVSGPMGDYGPAGQQGPMGPPGIRGPRGIDGINGMVGSTGKPGRNPRYCPCSMWRIKMNLLTDGGKYKIWMTDLVQNSADATVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYT7</accession>
    <name>A0A0D8XYT7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYT7"/>
    <dbReference type="STRING" id="29172.A0A0D8XYT7"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="847" mass="94103" checksum="607BAC21412404E9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ39</accession>
    <name>A0A0D8XZ39_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ39"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="15972" checksum="D4B9B8663B0F2E99" modified="2015-05-27" version="1">MKRVEQDDSLKAEKNPNCGFSWQSSVERFHRVSASGLRPTTTNTGQMTTLDEFHGSLHNVLETANDDSTTTIDVIANNVTIVCQITIIIGVKKAGTRALLEFLRLNPNIRAPGPEVHFFDKNYHKGLEWYRLSSYCGEKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZI1</accession>
    <name>A0A0D8XZI1_DICVI</name>
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    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A0D8XZI1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
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        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
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        <property type="entry name" value="FIDO"/>
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    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="386"/>
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            <begin position="333"/>
            <end position="340"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <end position="366"/>
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        <ligand>
            <name>ATP</name>
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            <position position="242"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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</entry>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336123" evidence="1">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="14465" checksum="88F8223AF594A184" modified="2015-05-27" version="1">MYAASIFIFFTLFISSESLKCYVGSKGLINGLLSTDFAENDCEEGMTHCFDSFSDDLTEITASCQTLNTDKKLLDVCKIGCQNHTQLQVTVCCCDEDLCNLPDSEKPTGRPSVSTQEVHYKLKPLKLSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y273</accession>
    <name>A0A0D8Y273_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH50968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y273"/>
    <dbReference type="STRING" id="29172.A0A0D8Y273"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="17810" checksum="735C0B727E987469" modified="2015-05-27" version="1">MLNYLRTPETRTTQIVPTIGFSMTNFTTHNFSITAFDMAGQGKYRNLWETYYINSQAVIFVVDSTDRLRMAVARDELWMILDHKDVSGRPIPILVLANKMDVKDALTSAEVSISLGLDLIRGHKWNIHSTCALNGAGVQEALEWLSNEIKTYLDSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2B1</accession>
    <name>A0A0D8Y2B1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH51013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2B1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2B1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="26799" checksum="D15808ABB4335382" modified="2015-05-27" version="1">MTIARKTWSRRFKIFTICQEAPMRAAVEDLANLMGSFFVDVDMVFSDVAAGLFLVAHSSTNTYPPLIPLCTGWQPWMAVENALHFQYFSSCVYGWPTYLLHNCGLRSVCRLVQKLQCCGKFPCDQVMIIEDNCCLCNMAAITLSIEHRNIDVFFASFRNGLYEVPFVVFADHETHSIVISIRGSRSLVDLVTDLCLGCLFVKLCVPVMIAKLDCYFLWFLVKNELFLTLKPNRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2W3</accession>
    <name>A0A0D8Y2W3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2W3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2W3"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="187" mass="21163" checksum="23035850F6DE54A2" modified="2015-05-27" version="1">MTHLTRLTLSHNKLTSIPPNIADLENLQIEELPSSISSLSKLRILNVGMNRLNVLPRGFGSFKSLEILDLTYNNLNERSLPGNFFFIDTMRALYLGDNDFEMLPGDVMNLRNLQILVLRDNDLLTIPKEIGHLTNLKELHIQGNRLTILPPEIGQLDLIGNKQILRLEYNPWLPSIQAIVVIGATVF</sequence>
</entry>
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    <accession>A0A0D8Y344</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="4">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
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        </reaction>
    </comment>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="217" mass="23234" checksum="D4EBB9C274DC53A5" modified="2015-05-27" version="1">MKNALLIIADGAEEMEVVITADVLRRGGIDVTLGGLTGPGPVKCSRKTVITPDCALTDLISKTFDIVILPGGQPGSNTLAASSMVGQILKSQHDAGRYIAAICAAPIALKSHKIPANVVTSHPSVRKQLEEGGYKYSEDRVVVADCIVTSRGPGTAFEFALKLVELLVGVDKAEELVAPMLSKMWWLTEVMKVGKSALNESDCRRLSLYITKAREEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y416</accession>
    <name>A0A0D8Y416_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y416"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="619"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="799" mass="89804" checksum="F93223EAEBC22D31" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4W8</accession>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716228">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF583">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="431"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="764" mass="87460" checksum="CAF0ED7317CD33D0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y593</accession>
    <name>A0A0D8Y593_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716225">
        <property type="protein sequence ID" value="KJH49716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y593"/>
    <dbReference type="STRING" id="29172.A0A0D8Y593"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="22649" checksum="CCD0A4286FAC49EF" modified="2015-05-27" version="1">MVDTSSTNAEPGNKKSLPMECLQRLKNFDEALTSLELALEPMLSVGFDEHMKRSGLGLVQVDVMTMFVLNSLGWCLVAQRGRDPKDNVQLADELRRTKQYAERLKSIEARKSAPTINKQVAKAFVRNALFEIPSKRARCDSDVPEEDTAVDESQSDESTDNEEVELITPTVMGEPSHTVTNIRFEDIDKPQKPAKIITGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5F4</accession>
    <name>A0A0D8Y5F4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5F4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5F4"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="656" mass="72766" checksum="9D41C3E216AF4391" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y612</accession>
    <name>A0A0D8Y612_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y612"/>
    <dbReference type="STRING" id="29172.A0A0D8Y612"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="757"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120654" checksum="371A2281FBA012C2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6A2</accession>
    <name>A0A0D8Y6A2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent NAD(P)H-hydrate dehydratase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
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        </reaction>
    </comment>
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    <dbReference type="EMBL" id="KN716215">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:metabolite repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
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            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="15928" checksum="70C19024CCEC834D" modified="2015-05-27" version="1">MAASETAYIILVSLSKGSCGKIAVIGGSIEYSGAPFFAAISALKLKFFFWGADVVHIMCAPEAAPSIKGYSPELIVHPGLEPGNVLTVLLNLEKMDAVVLGPGLGRSAQVFPLFEAVLSFVQRTDIPLVIDAVSQKYTFTLFDYVDKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6M2</accession>
    <name>A0A0D8Y6M2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6M2"/>
    <dbReference type="OrthoDB" id="5794962at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019420">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srbc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052322">
        <property type="entry name" value="Mito_rRNA_Mtase_NSUN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955:SF3">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46955">
        <property type="entry name" value="PROTEIN CBG01349-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10316">
        <property type="entry name" value="7TM_GPCR_Srbc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="25294" checksum="7C69DD589872D38B" modified="2015-05-27" version="1">MRIGSIPFMLQLKINLTLTISIAIERIMILCFPILFRKLANHSYATFCLSSGFLLGVTDLVLEFILSPFKRVPNCPTVGCFLTESYRVYWGICNMVMGIIVIILIAIILFKLQIIQQKSLSRGTTMDSEAKKFKQANRICTGILTTSLIFVTLPSVAVGFVEITGFSTFLAIGPFYITGLLCAGAFNSVIYVVLNRDMRDLAISIFTGNSITSKHSKPTINIITINKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6R0</accession>
    <name>A0A0D8Y6R0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative UDP-galactose translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_01956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Choi Y.J."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="234"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="389" mass="44277" checksum="A4D4F77B94E587AB" modified="2015-05-27" version="1">MTSIQFRHRRVILLRMSPDIIPLWNKHRLVIRLHVQLNTRGKFSTRLLGHCVVPLSELLFPPFLICRDFHFIAAKGMKFEGSSLIRIDLGSREKKLMEKITKMRDPILESNFVVDSNSVFNKNIIGRRSRSTSSSRNNLHMTENETPYPSKQKTITSRTDENESPFHTAASNIIAPKAKNLPLRERASSNLTDFSDSVFDDHVSVPDTSRPTFPYGDTRNLASSISRREFRPAARSDTSMSVKERERASPLRKSLIQLTVHEGRGLPLVLDERNRYVSPNSYISVLGRDGELRSAVCERSRRPLWNWTGRFYISGERRNIIVKVFHHDVDGDKTLGFVSIPLPIEEAHHVDYEMVDLTGTAIASGDVPIITVNFLHSPSTGEVLYCLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8W8</accession>
    <name>A0A0D8Y8W8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arrestin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8W8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8W8"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF159">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28363" checksum="88EB06D74534FEAF" modified="2015-05-27" version="1">MIADHCTEEFFLLEGRHTVPFEARLPMDVLSSIDRDNYGSVRYTCTALMVIPEDGDTEMVAEKTFKVYPYLNLDAPYMRDSTSTTEEEIIVGCCGRSRGSVVASMKVQEVGLLPGETTRITLTVEDRTRRKRWQRKKNTWHHPFQEQHECVLISLCQQLDFISSNRYESHLVDRKSVTIAVESHGTCKARPGSGPETKEIEFCVPSDLPPTSIHADRLVTISYFFKLDLEQFDIIVPVIIGTTKTPGTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9N5</accession>
    <name>A0A0D8Y9N5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9N5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9N5"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000003">
        <property type="entry name" value="Putative rho GTPase-activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="63"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="32639" checksum="2911B22568AFD8EF" modified="2015-05-27" version="1">MANSSIEYASNIGAAGTASFVVEEPRPSRESILEKLIRFFRNRPSVDALKEKGIYKHEPVFGSTLTAICQSENSLVPKFIRTVTELIESRGLEIDGLYRVSGNLSAVQRIRCQVDQDKYSALVNEEDVHVLTGALKLFFRELAEPVFPSALTKDYLNAIKLQNPKQRFKRFDELLRMLPAENRETLKMLLRHLLRVASHSDKNRMQAHNLAIMFGPTLFNSSDEKRPTKKKDGSKKKKDQKKDEIPAVQSNSHLAFNMIMQGQIVEYLLTEHSKFEALQGPVQTCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC41</accession>
    <name>A0A0D8YC41_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argonaute linker 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC41"/>
    <dbReference type="STRING" id="29172.A0A0D8YC41"/>
    <dbReference type="OrthoDB" id="1654885at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Argonaute linker 2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19981" checksum="B6490CACBA64FA18" modified="2015-05-27" version="1">MELCWIRPMQRVTVPQRTTDESFKTTRNCAIPPGERQDNIVRGANALRLFGSDDNIFVQNAGLRINKVPLKVQGRLLHPPRIRYGDSVAVARDGKWRISSGHFFKPAQCESWAIYAIIPRNEKGRFDEQLIWNFGRMFCTQASYRGLLLRRPMEIAVNLFHKHIFVEKKITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC51</accession>
    <name>A0A0D8YC51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC51"/>
    <dbReference type="STRING" id="29172.A0A0D8YC51"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF4">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="24395" checksum="1E1DF8DD3BCC2B0B" modified="2015-05-27" version="1">MGTASMILNTQIALIGAHKAYENVPITDVNEKAISETSKILHCEDRIVSNEDIFDTCSFPGSSIYLMFQTKFKYVEDEFLAFLYNQHEKAGWLTQYNIHHNISQRWYLETIEKTLAKLSRPSFSLAERIENEMRELFFNNTVDEFFFSNIDPLLRTLHFYMTAIQKLRKLSTYQRRSFKIDRFNASDMLSNDLDEFSLYHKSQLKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCZ1</accession>
    <name>A0A0D8YCZ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribulose-phosphate 3 epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCZ1"/>
    <dbReference type="STRING" id="29172.A0A0D8YCZ1"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16198" checksum="9E3A1C587EC5C3F7" modified="2015-05-27" version="1">MVNSSKDRGIQIRRFNMRIGLAIKPKTPVDKILHQDCYRFADKIDMALIMTVEPGFGGQKFMGDMMDKVRTLRRFRAALDIQVDGGIYSDNIQIWQIPAEAGANIPAEAGANVIVSGTGIVKAPCPQTAINQMREAVQTAITNYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD68</accession>
    <name>A0A0D8YD68_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription initiation factor IIA, gamma subunit, helical domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_01261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD68"/>
    <dbReference type="STRING" id="29172.A0A0D8YD68"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="9">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH52551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="473" mass="52261" checksum="31DB3FB572F3882F" modified="2015-05-27" version="1">MDGEETTEHVEQVFEFNDLPEPGHEEYSSDDEEQQSTSNFSDVEACGVIDDSSFALQAHEQDCFSVAVIAERWLASGGEDDVAYLWDNQVSDSVPVLKIDHDDSVIHVAFNNGQTLLSTGDMSGKIIITQLLDLKTRAKINDCNDLEWMCWHTTSDILFAGDKDGIVWMWLIGPRGVAQSKVYNGNGSSCTVGGLLPDGKRLLAGYADGAVRLWFLKDGNSAMVNVNSAISAVHHHVSQPIGVVGAENGSAYLLNTSHADKLTITMELIVLSKVEDSQKLNETAVETCVECVQFAPFNSWLAVGRNDGTLCIYETASGTLRSNYAAPSSQAIMRAVWSMEENIPILCVGSVDGFVRIFDARDGSLCKMTYYQMYRNTTLGEALQKTLDDLVHEQMIPPQLAVKVLAIYDKAINKALAQKAKNKMYFKAEKLRAYRHCDNVWTFLMERVDFRDSIRVARVKFVACDGSAKLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDQ7</accession>
    <name>A0A0D8YDQ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDQ7"/>
    <dbReference type="OrthoDB" id="5876746at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="485" mass="54108" checksum="48CB8EB01FB2801E" modified="2015-05-27" version="1">MTVSCVCTQKNLKQEIVHKDDLSSSVVQHDVGFFAYVKRHAVPVLVKVDKFNGSYERSRFLRQESSELSEKTVQVSDLYLIRSPSMYADGTPRAPLSDDDEEMEPAYSRALRNVNWNSEGIVPRNNAVGNLDRGSISSNDCVEATNSHILTNKSNSTNITEQRCERMKETGLILFAIHHVFEAQMQCSFNTLQTQEYSRRPWSDAIAGNKRSSPIPGSHDVQMTSRNNLEKNDDSCRRLLRPQPPPIPQGSKPKVSNGDRAPRASSVRSYQRKSRQDGLLEENPSPPRIRRQMCSTPLLRPESTSRSGPFVPRSESTATQCGTRAVGNGLQKSSCHSSSPRLTTKLSSPADMECRLGTRPSFIQNIPSVSQMPNGSQYGANPFIIAPYLPPGLMQVPPHFSPLQYPGIFCNNTLIPPFIDSQTGGQFFGAFNNRQDLLTTTITPVRILKTSHLNRKKCKTNAIIKRVDANEGVKYNKFGISFLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDX7</accession>
    <name>A0A0D8YDX7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDX7"/>
    <dbReference type="OrthoDB" id="5876161at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13660" checksum="67EF20099A066381" modified="2015-05-27" version="1">MNFSDVVVTLFLIVIAQGYVISPDSRIRSRREIFEDPERFKPRMAKIKIDDKYYSTEVPAMYDYAIWTNSYIENGEKVDRISVRIGNYIEVYKTVGGRTNVTDAKGNVLPDGGVFHVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDZ1</accession>
    <name>A0A0D8YDZ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_01038</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDZ1"/>
    <dbReference type="STRING" id="29172.A0A0D8YDZ1"/>
    <dbReference type="OrthoDB" id="5829003at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000035">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000038">
        <property type="entry name" value="Acetylcholine receptor subunit beta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH52831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="255" mass="28989" checksum="69A17059E9220D43" modified="2015-05-27" version="1">MAFLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSLSIPLVAKYLLLTFVLNIITILITVVICNIYFRSPITHRLPAWVRVVFLDWLPLLMCMQRPRRKNVLHQKRSNIPVSDSSQQFITSNHHPHCRAAENTRDGAPLIRISHPSGDELTPDAQRAVDAIDFITENMKDDEITKQYRDDWKFVAMVVDRLLLYGFFGITLGGTIGIVFSAPTVFERVDEHKHLQKLIHLYKQGLPVNDSLGMFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YG14</accession>
    <name>A0A0D8YG14_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein L-isoaspartyl/D-aspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YG14"/>
    <dbReference type="STRING" id="29172.A0A0D8YG14"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="32322" checksum="87857492EA81AB7F" modified="2015-05-27" version="1">MRRCLRSSFRLLSTCRYTLLVQTVLIVTLIAASALMTEKRFTLQQALTVYHRLKQRATEAVRSNSRMAWRCSGNSNEELVRNLEKGQIFSSSRVRDAMLAVDRADFSPISPYRDQPQGIGWNATISAPHMHAAALEYLKNHLVEGAYALDVGSGSGYLTVCMAIMIGSTGKVVGIEHIPELVDLAKENTRKNHSDLLDSGRVVFVEGDGRKGYPMERKFDAIHVGAAAETIPNALIEQLAEGGRMLIPVGKERGNQVFLQVDKANGSVTQKVIEHVIYVPLTSKAHQLGRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X517</accession>
    <name>A0A0D8X517_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722709">
        <property type="protein sequence ID" value="KJH39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X517"/>
    <dbReference type="OrthoDB" id="5834495at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7206" checksum="0AC1E7E99E25E396" modified="2015-05-27" version="1">MDKHLKGSKKNSILKSQKTEVDGEKATIDDDQNAHKRRVSFHSLKTVQKFEESHLKSVGWVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6J5</accession>
    <name>A0A0D8X6J5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAWUL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717723">
        <property type="protein sequence ID" value="KJH40143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12322" checksum="E1C12C010406E434" modified="2015-05-27" version="1">MTHWKVQIVALKVIVSLIPRDPEQPKPNRSIVRLSGMATVNTLKRYLAHSMWSNMSRYSELDLFCNDELMGRDFPMRFIHLTRCRNKLEDEPLKLVYRYHIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6R3</accession>
    <name>A0A0D8X6R3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5 / SMARCB1 / INI1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717526">
        <property type="protein sequence ID" value="KJH40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21086">
        <property type="entry name" value="WH_NTD_SMARCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048664">
        <property type="entry name" value="INI1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21459">
        <property type="entry name" value="INI1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWI/SNF Subunit INI1 DNA binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="27374" checksum="371AC2107B0BDBBF" modified="2015-05-27" version="1">MTISNATYGPRPRSFTMDDSGERYYIGSEVGAYLRLYRGTLYKKYPVLWRKVATVEDKEKLRQTARSQAFMHTNIIVFNKRLLRLVKAHEIDELLSGQEEKCRAATTTPAIPRVESGIAEIMCEDLDLPTSIFQPAIASAIYQKKLRLRSLPLDPNITDQRAIMKLNINVGNQSLVDQFEWDMSNPDNSPEQFARNLCAELGLGGKLTSAIAYSIRGQLQWNQKTYAFAESPQPTLECSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7K2</accession>
    <name>A0A0D8X7K2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722871">
        <property type="protein sequence ID" value="KJH39629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7K2"/>
    <dbReference type="STRING" id="29172.A0A0D8X7K2"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17006" checksum="B67E27B86A8FEC80" modified="2015-05-27" version="1" fragment="single">MRSPHTRLIHHTPLPPPSPPPPLLPQQPLSLMSTVGVPLLPVGTIPPSVAPTPILQLMPSQISPMPMHNAFLLSPPVVPVNINYAVSAVKCFTRALQLAPGSRLEDTLRLLQLWFDYGEYNEVYKQFSENMKGLAIETWLEAIQLMARLDSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7L2</accession>
    <name>A0A0D8X7L2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_14481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN722723">
        <property type="protein sequence ID" value="KJH39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7L2"/>
    <dbReference type="STRING" id="29172.A0A0D8X7L2"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11936" checksum="758A77B156E86D80" modified="2015-05-27" version="1">MLRCRAIQPLEENNWGLTGEQIQAYIEKDLRKGLIPCLISCTLGTTATASSDKLTSISPVAKKYDAWLHVDADYAGSAFIVPKNREVADPLRRILRTLPVKRYYGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7T4</accession>
    <name>A0A0D8X7T4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717085">
        <property type="protein sequence ID" value="KJH40608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7T4"/>
    <dbReference type="OrthoDB" id="5826231at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="320" mass="37876" checksum="A7D96179D2E0F61F" modified="2015-05-27" version="1">MEFRPEYGRPPPEFYRNIDYSDYRDFRDADQRSHEFLDYSRNENPQRARSHSRLDPEFIPSEFLYSGRPLEKSFRSKSLDHHDGFRDEPRFFEERRGVNIPIHRERIDRIYDHDRDVYTPFTRREERKDGLSDTMRRNGTNPREMDVQAKRVSKVLTRSNEWIGRRNGDRLRSTRDIYKAEGHSPKSASSSKRHNLNISVDPVRARRDYARPEEYVGYGHDDGREMYRAEGRNVDGDVRGGAKKRQTYSSYHYESHGGGYGSPSRRMPITQQPHHASSGVEPVVLNPIRHHQVKCCCLSFTWPPWSYEPTTPPQPLYRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7U4</accession>
    <name>A0A0D8X7U4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_13406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN717075">
        <property type="protein sequence ID" value="KJH40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7U4"/>
    <dbReference type="STRING" id="29172.A0A0D8X7U4"/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="301" mass="34707" checksum="53A1A55A8BB924DF" modified="2015-05-27" version="1">MSCRRWRTCLHSFGVCPPSFGFNYPSLRIMRRKLSIGVYDVNKDEKLGMVVKGSSPLWIRILMGILRAWFFIYDCLNYIPYQLFNPPVEKLWKSSAVKAQWIGGRDEPIRHVDGLKTEEFHRKYTVDKVWRHVVELYDEALALGTRQLLTVHEDATKDLTEGIEAKLVIFAETRAHWLITALSCFRANIPIVTVYATLGENAIAHAINESTLPLPHPSQCTSVEMRGPPPAWIPPCPPGRDRELDYENNYDDSEDIREKVRWSTNIRYIDSPMHNAIVFEDFFPLLAYSYGHSIVFGIFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAE4</accession>
    <name>A0A0D8XAE4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716804">
        <property type="protein sequence ID" value="KJH41543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAE4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAE4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14739" checksum="F87EBDCC2F6CD8FE" modified="2015-05-27" version="1">MTNVFLKAQNSEFVMGGGNTNPDGLQGITQTEFDYEVHMYSYYYLGLGLAIFITSYVQIYCMEIFAERITYRMRQIYLKAILRQEISWFDLQKTGSLTARLTEFVNFYTLTFYNYINYISYDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAL9</accession>
    <name>A0A0D8XAL9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717012">
        <property type="protein sequence ID" value="KJH40797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAL9"/>
    <dbReference type="STRING" id="29172.A0A0D8XAL9"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59037" checksum="B882C01D30876F4B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAT4</accession>
    <name>A0A0D8XAT4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_13155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KN716985">
        <property type="protein sequence ID" value="KJH40882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAT4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAT4"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="10">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH40882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="26616" checksum="EB98F958041534E5" modified="2015-05-27" version="1">MLCKVMISQVVCPLYRCLSTTSISSGKIGTVAIIGAGLMGSGIAQVSATAKLNVTLMDKSEEILDKARKNIDTNLWRVAKKKHAEDKRAQDALVAGVLSRVHTTTSFEKVLENADLVIEAVIEDIEVKRKLFSEIERLIKPYVSGSQVVRHEDTSDDTFETLMEYGKDIGKKTVSCKTSHPTFQDTPGFIVNRLLVPYMFEALRMAERGDASIESTLFKFSGVPVGQRCSTALPHMAPSEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB79</accession>
    <name>A0A0D8XB79_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN721313">
        <property type="protein sequence ID" value="KJH39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB79"/>
    <dbReference type="STRING" id="29172.A0A0D8XB79"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF32">
        <property type="entry name" value="STRESS-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="17025" checksum="25F3953782DDC641" modified="2015-05-27" version="1">MALWPVSPLDSFMVDPVGRVMRDIDRTLMPYWRNADHSVLHVGNTTKEFVNDDKKFAVSLDVSHFKPEEIKVQLEGNELIIEGNQEAKGENSYMKKSFMHKWALPEDCDVDAIHTQLNDAGHLSIEAPKTGQHPRRRNIPIMAAPKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBJ2</accession>
    <name>A0A0D8XBJ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716727">
        <property type="protein sequence ID" value="KJH41985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBJ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XBJ2"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="169" mass="19780" checksum="EB815641DCDE3F9D" modified="2015-05-27" version="1">MVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLELSEEKALEKEDVFAEQIRQLDFRLKEVRPPSYSDDKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTISARLKEAETRAEFAERSVQKLQKEVDRLEEEKDEADRKNRQLQEELDHLLTELNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBW3</accession>
    <name>A0A0D8XBW3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716708">
        <property type="protein sequence ID" value="KJH42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBW3"/>
    <dbReference type="OrthoDB" id="5801732at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF121">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335482" evidence="5">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11161" checksum="0047EB0504383651" modified="2015-05-27" version="1">MQILLVLCSMIPFVYGIGRTQAVGVRGVLICNDKPASDVEVKLYDEDKLSPDELMAVGRTDSRGQFEIKGHADEFTSIEPKLNIYHDCDDGIKVTVSAIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC00</accession>
    <name>A0A0D8XC00_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="241" mass="28020" checksum="8B139C453F1F422A" modified="2015-05-27" version="1">MVIHFAAITHVDESYTDRVGTIRDNVISTTSLLEYEVYGDSFDDNTPKTEDSQLNPTNPYAASKAACEMVIRSYWHSYKLPYVMVRMNNVYGPRQAYTKLIPKFTKLALDGKPYPLMGDGLHKRSWMYVEDCSEAIRRVAEDGQLGEVYNIGTDFEITNVDLTRKIHDIVNKLKRRERSNPAFMPIPDRPYHDRRYYIDFSKIREAMGWQCTTPFEEGLMKTIDYYLKQGKQEMATSRLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEL9</accession>
    <name>A0A0D8XEL9_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716706">
        <property type="protein sequence ID" value="KJH42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEL9"/>
    <dbReference type="OrthoDB" id="5858892at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF418">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="320" mass="32847" checksum="BAFB1C8B3BCC0DA9" modified="2015-05-27" version="1">MSHRIVHIQIPLQSVVSNELNILSSTMRETSLIASVSLVAGAISLFGAMVFLPRVYWEMIDLRDEVLDAVGSFKVETDSSWIELMDVQLSHSPPSKPRENPLLRREKRFADLPEWCQCDSVPQCPPGPPGPPGPPGLPGVAGIPGPPGLDNENFGVPMMACYPPMGCIRCPQGPPGPRGPDGIVGQQGPPGVPGAPALAYGLGRGLPGPPGPPGDPGIDGRPGIPGPPGFPGRDATGYKKTRGPAGPPGPPGVPGVKGIPGAPGFPGQDGPPGLIGTAGPDGLPGEPGKNGNVGQPGIPGRDAEYCPCPPRTSYLQQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEN4</accession>
    <name>A0A0D8XEN4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="KN716597">
        <property type="protein sequence ID" value="KJH43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEN4"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="MSP_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CBG16675"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="31"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="139" mass="15506" checksum="1D6ABED243A98CAA" modified="2015-05-27" version="1">MEYVMRTARSSRGISRDREPGCTCCCHLKSAVTISPRSAHFKKEGGLSTHNIMNISKIRLAIKITCSDNTLYRVTPVYAIVEPEEVIVLNIGRIEGEAKKDRLGILMIDYSGTGNAKEAFKRTDLRPVTINIPLIVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEW5</accession>
    <name>A0A0D8XEW5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716685">
        <property type="protein sequence ID" value="KJH42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEW5"/>
    <dbReference type="STRING" id="29172.A0A0D8XEW5"/>
    <dbReference type="OrthoDB" id="10266736at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="5">
        <location>
            <begin position="257"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="249"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF21674"/>
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        <source>
            <dbReference type="EMBL" id="KJH42277.1"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
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    <sequence length="527" mass="61676" checksum="F3F76E67DB3D6DE2" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGV7</accession>
    <name>A0A0D8XGV7_DICVI</name>
    <protein>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716517">
        <property type="protein sequence ID" value="KJH43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGV7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="14108" checksum="3BF033E91F14744D" modified="2015-05-27" version="1">MPKSNDMLHDRLTAVGFGIDRRHIRLPARNESKGNYAVPNVLPSKIQRRHIRLPARNESKGNYAVPNVLPSKIQRAIPSIRRCAVPGTNNIRSEHLKNLSPFPIKTPVRLFIRCLSKYRIPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH70</accession>
    <name>A0A0D8XH70_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716593">
        <property type="protein sequence ID" value="KJH43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH70"/>
    <dbReference type="OrthoDB" id="10030973at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="112"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="524" mass="60237" checksum="5F91586465DC0020" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHB0</accession>
    <name>A0A0D8XHB0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_09926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716503">
        <property type="protein sequence ID" value="KJH44060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHB0"/>
    <dbReference type="OrthoDB" id="5864520at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF898">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335883" description="Peptidase M12A domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="572" mass="63080" checksum="487EB0D4C819076D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM0</accession>
    <name>A0A0D8XHM0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KN716498">
        <property type="protein sequence ID" value="KJH44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHM0"/>
    <dbReference type="STRING" id="29172.A0A0D8XHM0"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="100"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="487" mass="55569" checksum="ED7B727C50FC9016" modified="2015-05-27" version="1">MPNVNVKWGKEKYNVLLDLDESPLVFKSQLFALTGVPPDRQKVMIKGKTLGDESWKGIVVTEGLMIMMMGSADAVPAPPKSEEEPNELTRNDSGIMRLPNGLKNLGNTCYMNSVLQTFKADGLLQLKQGISNPDVNQKMAMAVKSVYEMLDNPRRTNEPLVPFFMLQALHSILPQFSSRDEHGHLEQQDANECFSEIQRLLLNALSSNKELIGKDIREYFRGQYQVRQKCLECDDEPIQNTTEEFYQLSCFLSPEVRYIQSGIKEKLSGEIEKTSTILGRNAKWERNVLIERLPAYISVQMVRFFYKESSQVNAKILKDVKFPMILDLRDICTPALQEKLLPQRAAVKKEEDAKIDRMQKRKMEVNESKASDDDGIPLPFSFPDDEGSNNSGFYELKAVITHKGRSSNSGHYVAWVRMNEEQWAMCDDDRVTSVTSDEVLKLSGGGDWHCAYVLLYGPRIIKEYPELKDEKENIVEQTKEIENMKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIA2</accession>
    <name>A0A0D8XIA2_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">DICVIV_10484</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716553">
        <property type="protein sequence ID" value="KJH43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIA2"/>
    <dbReference type="STRING" id="29172.A0A0D8XIA2"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38006" checksum="E371076A330AAD67" modified="2015-05-27" version="1">MNDVTKVNGDALLNTATLSDSDEELYTSSIDIRKVRAVVDDNNILKQVTVHSDVLQDDKPHTLEQSDDDSDSLELSEPENSSPTKLRKLRRKRIERMEHEDMLELEEILSDPVIQVASPLRKKAMLTRSRKPNLQECPEIVLDDSTSLIEEQVEQRRASCDAVVVDLGKEVNLFVTVCVDQGNGRPGKFMTIRQDEPFDSLRPIFAKELNCSQLDVLIHVNKVDAGPGDTPHSMGLDINKLAVVNVFSLKSNSNIQDDLSTNPNFIPVKCVFANVKPRCAYISMTEPFYMARKRIRKQLKLSHAIEKVIFDNEVINDTDSPESLGLEAEDVIDIHLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIB3</accession>
    <name>A0A0D8XIB3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09578</name>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716477">
        <property type="protein sequence ID" value="KJH44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIB3"/>
    <dbReference type="STRING" id="29172.A0A0D8XIB3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="178" mass="20555" checksum="F647BBF4B042197C" modified="2015-05-27" version="1">MIREDEFLSKLYGNAVPQWSNIAASQLTLYAIAHDIKTPSLLELQMILGMGARRHDYKRARKPVGDRKPRQAYTAVQLEKLELEFQSDKYLSVQKRIQLSRSLNLSETQVKTWFQNRRTKWKKQLTNSIRDIYRDQNVAAPLAMLPGLNPRHSSSSIPLGFSHTFIEPSQESENISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIH2</accession>
    <name>A0A0D8XIH2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low-density lipoprotein receptor domain class A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716706">
        <property type="protein sequence ID" value="KJH42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XIH2"/>
    <dbReference type="OrthoDB" id="10013209at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="9044" checksum="268AF9FAC3ACA588" modified="2015-05-27" version="1">MAFFFRWMCDGRIDCIDRSDEDPTICLKRGHRKFLDDSRRYLSRMRKCPETWFACADGSYCISSRFICNQIQDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIP0</accession>
    <name>A0A0D8XIP0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716539">
        <property type="protein sequence ID" value="KJH43644.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12423" checksum="C01BB2C2F078D9B7" modified="2015-05-27" version="1">MDHIHTIKRLIEVSRGYRKPLSLTFIDLKKASNPVEKETVMKALTNHALPTPYIKILAILPTVSFISLLRSYITRTLGHIQTVAFIFTIKFVSTLDEKNGYFFSIKDR</sequence>
</entry>
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    <accession>A0A0D8XIR0</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A0D8XJ43_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="237" mass="27360" checksum="2B9ABC5E4EC5115F" modified="2015-05-27" version="1">MIEDFKDRKRKGLRLWKCASIFQQSGQIFGVPIQTAIDMDPSMDGIPLPAFFRHAVNYVESHGIMQEGIYRLSCPKSRIDEIERNVNEGKPLCFSEGHEAAELIKSDVYVLARFLRQLPQPLLSGDFEMLVENCSCKWRNVCQCVVFPEMKKMLRRVSRPQFYLLGYMIMHIQNVINMPIHFKESINKMGIHALELLFQTIMNMSRHLICYLIVNGGGTLSKERKGDSLFGDLRIMP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
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            <dbReference type="ARBA" id="ARBA00008609"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135657" checksum="9CB749381529CAC4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJM2</accession>
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        <submittedName>
            <fullName evidence="3">Putative phosphatase regulatory subunit</fullName>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716654">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <end position="293"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="103"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="326" mass="37564" checksum="3AD549715E514569" modified="2015-05-27" version="1">MVGEKEWETCYHSTPAGYITGYRRAASFPFFGDHSLVPSSALKVRSQSESEGLNKICFSQVNLDTFRCRTREIVEECDDVSDCESDSSSTSEESVSSERKLETTERVTEVSLKSQKSVRFADDCGEELCSVRVMTEPSDYPPQINPSVLRKLRGHIPEDETSIKEEARAWVLLFKQPASEYVRFRETLEKGRVSLENVVIKENLSKLVGTIKVANIAFEKRVFVRYTTNNWQSYMDRQATYQPSNSKVYDTFTFELELPTVFEKSSRLEFCICYVANGTENWDSNGGENYKMDFKYMDRDDAYSMNQTDWTHFASWKSLSTDGPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKS4</accession>
    <name>A0A0D8XKS4_DICVI</name>
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        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716475">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335863" evidence="4">
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            <begin position="18"/>
            <end position="194"/>
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    </feature>
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            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="22582" checksum="51216872A9B5D50B" modified="2015-05-27" version="1">MPLWMSLCVNRVHFVLSFICYLSHNLSSMKQKDGSLALRRKCNLWRLLRLQGNELFAKKDFEKAIEKYREALGRLDTLILREKPGEAEWIELDQKNVSLYSNLSQCYLNVGNMYEASETASEVLSRDPNNEKALYRRARARIGCWQLDEAEEDLKRLALLPNTESLVKSELTALAQKRIELAESNKKTYSKMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKZ0</accession>
    <name>A0A0D8XKZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09531</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_Vesicular_Transporter"/>
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    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF13">
        <property type="entry name" value="VESICULAR ACETYLCHOLINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
    </feature>
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            <begin position="33"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="522" mass="57575" checksum="1ECCC4F7B963E215" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL04</accession>
    <name>A0A0D8XL04_DICVI</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716470">
        <property type="protein sequence ID" value="KJH44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL04"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="14839" checksum="25C2472355C43733" modified="2015-05-27" version="1">MEALIRVHVLRTAVVLNVLKSREINVFVPQGLKIDCAKVYKNAIGELPRNRVKNIDLNRTSLEPYRTNITKISYAIVFSVLNMGKRKDVGPYESSPTNPKKLSRNDSSSGSSSSGEWLCSSSRLPISCKGTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLU5</accession>
    <name>A0A0D8XLU5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716403">
        <property type="protein sequence ID" value="KJH45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XLU5"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14606" checksum="3867B2923BE0CDF0" modified="2015-05-27" version="1">MPTTCGFPNCKFRSRYRGQEDNRHFYRIPKRPQVLRQRWLLAIGRTEETVVSQLRICSAHFEGGEKKEGDIPVPDPTVDKQLNIELPPKETKGGDRKRNKGSPPVSRPVVVRKRQLRDFLRNPLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMS2</accession>
    <name>A0A0D8XMS2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="KN716384">
        <property type="protein sequence ID" value="KJH45825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMS2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMS2"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="385" mass="44176" checksum="B6796EA0CC69CF28" modified="2015-05-27" version="1">MGTIQRFRIGKEEPAEYISISSQQLYLLTSLYNSRANHTMTRKLTRFDILNTGESATEESVDRLCSQLLIKTPSRTTWSAMPSTSRSGTGISFSGTKKKSKKKQSSIPHKGKYDHLAQPCPRCECKRVRVVNTGRRDGRNIMECTRSDCLATIKFTSIPDGNLINPGAAPEEICWYDLNQEELFYPHHTTVNRLRESLKSTMEKQYQPKISYDSNGCIVVRCPGQKELVKLLQRAHSNPHSDHDIDYPRTPDDMDWEKLFGDFARNRQVEFADIGCGYGGLLVKLSPLFPDTLMIGLEIRIKVSDFVCEKIKALRMRSSDPKAFRNIACIRSNAMKYLPHYFHKHQLSKMFFLFPDPHFKNKKHKWRIITPGLLSEYAYVLRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMT4</accession>
    <name>A0A0D8XMT4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716429">
        <property type="protein sequence ID" value="KJH45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMT4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11803" checksum="36F1C2451FD70A35" modified="2015-05-27" version="1">MRRTIALVGNRTTLRPNGIRPEYLNNLLPVLIRASVELFTRYLSARKVSNKRKTNKIVLRYKKYTGTVMEPLTNQALNIPYIMSYALGSYSSKHHGKTGTGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN48</accession>
    <name>A0A0D8XN48_DICVI</name>
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        <submittedName>
            <fullName evidence="6">AN1-like Zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF67">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="356" mass="41196" checksum="EB9B4EBACAFAED84" modified="2015-05-27" version="1">MSPIGQSPTQNSMMAAIELFIHSVMEGVRDAKITIPVDATVFELKRLVHLATDVIPERQLLLFKDKELSAAEVMVFMPMRMPFGNSSLRNTIRTMTNVMDRRPKKIENTVIDAAAWTPAKQMEHEITRNRMKNRFIFKSVEPSRKEVMKSHEINYDCEQIYFTEHPLWSSSVFRIWLQKLLRLRKRTPASKTSSPQGIYTPGSVASRSPSGTMSPVETADNAAQISRGRTAKIEDLELTEKDLKVKELFFEPAESIDELYRTQQEICLPPETVADLLKFKKEKEEREKTMCKICRCKLPLSEQQIICHCQFVFCRKHREPSAHLCQIDYKQTGRRKIRKENPKVDSRGIYKAQMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN97</accession>
    <name>A0A0D8XN97_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_07906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716373">
        <property type="protein sequence ID" value="KJH46020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XN97"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:single-stranded RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="239" mass="26855" checksum="3FDECEA1E599964E" modified="2015-05-27" version="1">MTLWRLGILLHLAMNNSYNRSERTLFVSMMHKSITDDDLYEILTQAGPIEKIIFKQNKDGTPSHALVIFRNVESVVFSMVHIFPVVRSAGLIQIRPLRESSHHYFRTGSGHYGVSQIKNDAFSNEFLNFSKDDNTVALWNNQPPQKNLNKACAISYSDTKKKLSPGVAGETCKEHDDSHSQSVISKLYPLPNSFSLEKLPVVCNSLPGHIGNLKISMQPSMHRFPPHRGSCSKICCAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP11</accession>
    <name>A0A0D8XP11_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRO1-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716498">
        <property type="protein sequence ID" value="KJH44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XP11"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716376">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="198"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="146"/>
        </location>
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            <end position="190"/>
        </location>
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        </location>
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            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
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    <sequence length="428" mass="46571" checksum="3484101757F1CBBF" modified="2015-05-27" version="1">MDSFNQSIIVRTEFLDHTAPHYRMIDSCRSKPVMRRMYKRQATSVTSSGNAVVANNGTTTIAQNTTVASVVTTTATLNVSSEPTTTNDTSATEIAVIVSSETPVQTTTDGTDATVVAVVVSTVTSEQSTTDEAESTNASQETTTRSYVDEPITLKPNYVDEPHVPNKGKSSSAYNGNEQKGDQVSQSGQYGNIKVVPSGYRSKRASEYVDENITPLHGGEGDSYQPIGEENPAPIEQGYPDNEAPPVESNGYGDYDDNSGQTTRAVRRTTSIIRRTTTPVRRTTTPVIRTATPVIRTTRRIPSTTRRPQVTRTIPQRTTSRPYVTRPTTRNSNYADEPYVPEQGNSEGSYTGGEEEGQEVSQGENYGNPNVEPSGYRRKRASEYVDENITPSHGGEGDSYQPVGEENPTPIDQTYADNQAPPLEPAGY</sequence>
</entry>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_06641</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KN716314">
        <property type="protein sequence ID" value="KJH47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="11"/>
        </location>
    </feature>
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        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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    </feature>
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        <location>
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        <ligand>
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            <label>1</label>
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    </feature>
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        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <location>
            <position position="225"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="255" mass="28936" checksum="952D724C4E76491C" modified="2015-05-27" version="1">MAKTILVFDVDGTLTPPRQKIYDDTKQFLAEVRNHVPVAIVGGSDLTKIVEQLADSKEELLSQFDYVFSENGLVAFKGNEGYPSRAIQDHIGEERLQTLINFTLKYFSELTLPVKRGNFIEFRKGMLNLSPIGRSCSQCERDQFVIYDKEHKIREKFVQALEKNFSSYGLCFVIGGQISVDAYPIGWDKTYCLQYIENDFDNIHFFGDKTMPASCSIGGNDHTIFSDPRTIGHAVVGPNDTKQQVEQLLKDLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSF7</accession>
    <name>A0A0D8XSF7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XSF7"/>
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    </dbReference>
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        <property type="entry name" value="DUF236"/>
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            <begin position="92"/>
            <end position="269"/>
        </location>
    </feature>
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            <begin position="103"/>
            <end position="112"/>
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    </feature>
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            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
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            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="41851" checksum="FA00A15C73EC565A" modified="2015-05-27" version="1">MIFSIQLNFNIFPYFIVPIIFLASSCNSSKVVSISRKSAVKTLNENKLKNNVCKDVISIKSIKNNVTSSNSIKRKRLFPIVKDKENLEAIADEKKSRNSLKKKQSDVNDSNRETPASSKNEGVIKKKERNGFEAVEDEEGSRKLRNKKREDGKESKRETPVSSRRERRIKKKDGDEAEAVGNLGKSKKSRRKKQVDKDSKRETSAFSKKEVKLEEKDGGCIEGAANVEESKKSEKIKQANAEDPKHLTSTSSRRQKLKKKEGDKVEGLDDIKKMKEPEIKRIVDALDPNYRTLGFLSNEDLFKKTVDNNNVADSKRMKPPENKKIVDALDPNYRTLEFLNNTDLFKKKRPKKNENVTAVPVSFIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT37</accession>
    <name>A0A0D8XT37_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">DICVIV_06958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716326">
        <property type="protein sequence ID" value="KJH46982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XT37"/>
    <dbReference type="OrthoDB" id="5875917at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49552" checksum="2A3236E47382BF90" modified="2015-05-27" version="1">MDSAVKTRRSTQESFELQQLEFNAQMAGILDEGMLRDSCSLQQDRDLIFEEGEEEGGDHSVGPDFECNGIEVIWLANNELNNASADRESEVFYPTVHVGANETATVIGTSWSITILSRETFSARKICRTGSPTSPDDLNNNGVDPNQQSPILPQTSLDGQHRPEPSQIETRFEEKQVHATTSEAFTVFSEANIKEQQHTRSSNLWMSKLQEADVSVSSATTFSADQLDHPNTYMEDSQSFNAQFSGECSPLVGNGKSEPERKLVGGYVLPQNNFQLSMSNFHQNGAIASNSNHLLPQQQNYGFTNSANTYLTYAIMPNNQISQNVLPVYMNDGLSYNQAFNISNNCDVNANVFSYNMGQHRQSEQNVTQLEISSSLGSPSTFEANREGIAENSCHDFVPLHQTMCTYSSSIGTLPTSSFFNQLSTDSSCQHYTSSITTNKVSHLLLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTD4</accession>
    <name>A0A0D8XTD4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal cation transporter, ZIP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716396">
        <property type="protein sequence ID" value="KJH45641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTD4"/>
    <dbReference type="STRING" id="29172.A0A0D8XTD4"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF76">
        <property type="entry name" value="ZINC TRANSPORTER ZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28212" checksum="FE06BD3E05BDD2A7" modified="2015-05-27" version="1">MLESEAVIQSYKMNIIILKAILLGVMVIITVIFGLIPIKLLQFLTTKSGIVENRASFIVSILSCFAGGVFLGVCFLDLLPDAYSSYSNWKAWSKFDSDYPFVSLIFVSGFFIVKIFEEIIGKFCGPESERNERRRHLSTFVSVENDFECRNAEHQQVNKNVDIAKSLTFIIALMFHASLEGFAFGVQRTLPSVASLFCGIIVHKAIVSFSVGMRLFEAHSDRIWLPIVCIVSVALVTPLGGTIGIVLEDPQMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTF0</accession>
    <name>A0A0D8XTF0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTF0"/>
    <dbReference type="OrthoDB" id="5807587at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="368" mass="40206" checksum="A043CB883165321B" modified="2015-05-27" version="1">MEKSSLKVNQKLGLAPNHDSAVISVYQQFGNEEILIWTQSGLTLIGWNRIRLPIRFSPLPSKLLIKTSTTHGQFVAITNTNIVDESGRDLACGGDMLVIRPRNDDLVRLTAMQKLDSYQIESSSIPTLFMVSPSTLAASSAFLSPSLSSPTMNSFSISSPTRVAPSPFATLPISPAQVFTRQHQRSNLGYRAKAFSATSINDNTKITTSNSFNNPQRLPPPILAVTEATPSLEKLLASLSGRPVFDGQLKYLAKKFGLDRLPGDQIVQRYGIIQRMVDELQRNKSSIDKQPITPANIKDTGGSALPLEEVSKLASSVLPSSRTINGALTNRISQLLSPPPDMGDDSKPFSRNSMDFVIENAYNAYINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTJ9</accession>
    <name>A0A0D8XTJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716394">
        <property type="protein sequence ID" value="KJH45676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTJ9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="17917" checksum="9320DB8EFB248A16" modified="2015-05-27" version="1" fragment="single">MSYWSRGAWLHNANEILNFCALMFPTMLMYYIASILSFFLINELNTRGNLVEGLSCYSGRDGVYNKTVCEKHLKVCYVTHCRTATGDLDIRGCDMDGNGCRSVLKLCIRKNKKKNCHVCQDDLCNSVENFTRISSMSSSPISLLFFSMLLLLFLVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUN3</accession>
    <name>A0A0D8XUN3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:neurotransmitter symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716303">
        <property type="protein sequence ID" value="KJH47542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUN3"/>
    <dbReference type="STRING" id="29172.A0A0D8XUN3"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF279">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="22442" checksum="14635B67C6E4301C" modified="2015-05-27" version="1">MRYGSLWSFIFFAMLITLGIDSTFAGIEALITGLCDEWRLLHNKREWFVGVVCILYYFGSLPAISYGGQYVIPFIDEYGVSLSLLFIVTCEMVAVCWFYGIDRFTNDIKTMLGFYPGIYWRVCWMMCPVFISVIFFMTIWQVSFSPMQLSGYTFPKWSVRLGWFFRLLSVTSVPLYAIYVLSSARGTLTEVILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVB8</accession>
    <name>A0A0D8XVB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="KN716360">
        <property type="protein sequence ID" value="KJH46296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XVB8"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="21235" checksum="27669B0B567F5443" modified="2015-05-27" version="1">MICFVTVGTTRFDQLVNEVLKEDCISKLKSLGISKIRIQLGAGEWNDDVRKRIFRGVIGDEGEGESDGVTVEFYRYKSNIQSDMDDASYWFFKIVIGHAGAGTCLECLKLRRPLIVVLNEDLMNNHQLELAKELARRGHLLYCRVPQLCATLSDPALFSLNPFKPPDQYLVAKYIDNLMGITPSLVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW06</accession>
    <name>A0A0D8XW06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box' domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716347">
        <property type="protein sequence ID" value="KJH46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW06"/>
    <dbReference type="STRING" id="29172.A0A0D8XW06"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF27">
        <property type="entry name" value="PAIRED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="99"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28916" checksum="7AE95D22C0EAF75E" modified="2015-05-27" version="1">MMSYYIPQKEKSLSNNMNEFSDEGIEKPKAKIICILNLPIECLKNLPIECLKGMAPSVSNTYYTSSEAPRLTTELSEDNDVLPETVIDSAKRDDVRKPRRKGTNLYGRPYCPGRPLSMVERRRIIDLHMSGMKVNAISKALCISHGCVSKIISRYRQTGILSPASSPEQRRTRRKKNESPSSATSLVDLHEYKPEFKHDYTHSTTVADYTAHDFRLHYATTTPSHGVVEMAAMQHYTMLPEQMLMQEYPQSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWA3</accession>
    <name>A0A0D8XWA3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWA3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWA3"/>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="314" mass="35739" checksum="3D3F048F9FFA4437" modified="2015-05-27" version="1" fragment="single">LNSLNLEFHYLQLVSNGAYGAVYLVRHRKTRHRFALKKMNKQTLVLRNQVDQVFAERDILTMTDNPFVVSFYGSFETKHHLCMLMEYVEGGDCAALLKSAGTLPIDLARLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGFENAADTQQFRDKQLCGTPEYIAPEVILRQGYGKPVDWWAVGVILYEFLVGCVPFFGDSPEDLFSKVITGIRPYICAVSYFSSSQRHIYIFLRILLNRGLSFRVFGDLEDVEYPDEDEALPADAENLIRRLLEKNPAERLGMRSVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWV4</accession>
    <name>A0A0D8XWV4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716273">
        <property type="protein sequence ID" value="KJH48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
            <begin position="699"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="748" mass="84629" checksum="2D94B479FC135EE9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX96</accession>
    <name>A0A0D8XX96_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ShTK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716268">
        <property type="protein sequence ID" value="KJH48442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="231"/>
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        <location>
            <begin position="76"/>
            <end position="110"/>
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        </location>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="24128" checksum="F63DDDC23372D7C7" modified="2015-05-27" version="1">MIIEWIAFFFIHTVSAQYYGSYYGRYGCPLSRTTAGYLSSFGWGSPSYGMGGDPYSAVNPYAMSGALVDPAISGLCVDTSMQCPIWASTGQCATNPLIMRRMCARSCGTCALGNMAGLGVGTGIAPGVVPGIGTGIVPGIGTGIAPGLGTGIGYGAGMNLGYGELGVNPLAAPLLGRSIYEQVCINSILIFYGFELATNIETSDETRTDIPADPPEEFYDHRKNPQSILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXE3</accession>
    <name>A0A0D8XXE3_DICVI</name>
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        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">DICVIV_04577</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
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    </dbReference>
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        <property type="reaction ID" value="UER00840"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
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        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
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        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
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    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
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            <begin position="3"/>
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        </location>
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            <position position="1"/>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50968"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KJH49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="395" mass="43316" checksum="71DD149AEB632E02" modified="2015-05-27" version="1" fragment="single">NDVIIVEGPAFAESITEGDIRWTKKVGDFVNEDELVAEIETDKTSVEVPAPQAGTIVELLVEDGAKVTAKQKLYKLQPGSSGATSTSVAKNTIKSVETLGKNKRRIFSRLFASCLEFGDIPKTMPPVTPPPSMPISSVPVTKIPVQRVTVPTGVAPELAITGAREEIRVKMNRMRQRISTRLKDAQNTYAMLTTFNEIDMSNILDMRTKYQKDFMNKHGVKLGLMSAFVRAAAYALTEYPVVNAVIDGNEIIYRHYVDMSIAVATPKGLVVPVLRNAETMNYAQIEKELAALGEKARDNKLAVEEMEGGTFTISNGGVFGSVFGTPIINPPQSAILGMHGIFDRPVAISGKVEIRPIMHVALTYDHRLIDGREAVTFLRKVKSSVEDPRTILMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XY45_DICVI</name>
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            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">DICVIV_04435</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    <dbReference type="Pfam" id="PF00536">
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    </dbReference>
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        <property type="entry name" value="SAM"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="805" mass="88500" checksum="D63FCEA5BC4BAA47" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XYK5_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">DICVIV_04956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM RBM34 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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            <end position="351"/>
        </location>
    </feature>
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            <end position="437"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJH48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="504" mass="57832" checksum="E702B8F28B14A121" modified="2015-05-27" version="1">MISNLFLLMGRKTKLLPSNEGLKPTANNATGDKMEYEKTECGETLCVRTGFKMDTELMVFVFCLYYQLCNYNIGCILHAYRRIQKFRDVLILSESVAIMSKNRKRKSSNKSKSVEYQKCATSGEIEHINKKPATKSYEIFRDYEVDEKKSTANNKNDVQTTNEILKQPQDKYVVGSLSSLFGGIPISDSAKDSDIVFNEGESVIKPKKKRRNIDDAANLKKAESRVEMAHQKNCRLQQRMNRKRAHEKRMSLDEKKRTLFVGNAPLSMNERSCKKLFSQYGEIESVRMRNVIPSKETITKRIAHLSHLFHENQSSVIFYVKFKDEASVEKALAYNGTVLDQHRIRVDTCLSKAEYNKKHTVFIGNIPLNTKEDELADFFEEAVGDVDFVRCVRDHSTGMGKGFAFVIFKSPDSVQMALSMTGSLFHKRELRVMKVMKKSKIMKLRSIGKRSHAELELTKAQSNKINQYKFSTRKPQSDKRPRLTKSARKAIQKKKAACIKSIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYV0</accession>
    <name>A0A0D8XYV0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_04206</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XYV0"/>
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    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
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        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="482"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH49660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="567" mass="64466" checksum="B3F997CF1DDC5125" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYZ9</accession>
    <name>A0A0D8XYZ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10792" checksum="9CB5ACFCAB8411F7" modified="2015-05-27" version="1">MSEPPSLEDILAKKRKEEEEQEKPKFLSREERAALALQRRAEQVEKMKENQRRIEESRRQFEAEAKKYVLTEKQWHTVELGYLIVKNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZJ9</accession>
    <name>A0A0D8XZJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein, SNF2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_03924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18666">
        <property type="entry name" value="CD1_tandem_CHD1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000014">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <location>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="380"/>
        </location>
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        <location>
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        </location>
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            <begin position="743"/>
            <end position="894"/>
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        </location>
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            <end position="78"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="972" mass="112035" checksum="DD2D02D498893EEB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0A9</accession>
    <name>A0A0D8Y0A9_DICVI</name>
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        <submittedName>
            <fullName evidence="11">TM2 domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">DICVIV_04304</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
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    </dbReference>
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        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="22792" checksum="15992E96D26DF1F5" modified="2015-05-27" version="1">MILALVFACIGILEGNSNRARASLMMSGRRTGGHAHCSRIDCEMDASCLHCTFPVDCELDEEVEVNCTSVKECGPSQISVKRNAYCRYCWQSDPSDYDCLPQSNCSTTSWQLVPTECSVHPNVICKGRRVFNKRIRCNWSSGISWAKTMFLSVTLGGFGADRFYLGLWKSAIGKLFSFGGLGIWTMVDVVLIAIGYIRPADGSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1G7</accession>
    <name>A0A0D8Y1G7_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_04000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH49889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="24019" checksum="7E403FDA151436EA" modified="2015-05-27" version="1">MHVSEIFRCPPTAATSAQNEHELSEVDRHSPSSSDLTDGLTPHDVEEYQMDHSIIDEPLEQSLDSIEDLKPGYQCRFCPTRFDERQQLNSHYSTCHRDKPQYECDVCHTIFAVKRELSTHLRTHSGEQPHTCTQCGKEFGTRQLLKKHWMWHTGERSHVCKHCNKAFFQKGHLTQHLMIHSGGRPHQCSLCQKTFIFKVYGSFLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y243</accession>
    <name>A0A0D8Y243_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="EMBL" id="KN716215">
        <property type="protein sequence ID" value="KJH50119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y243"/>
    <dbReference type="STRING" id="29172.A0A0D8Y243"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000040">
        <property type="entry name" value="Putative ribosomal RNA methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="38127" checksum="48C3C14AF2D9F365" modified="2015-05-27" version="1">MGKTSKDQRDIYYRMAKEQGWRARSAFKLLQIDDEFKILESNLNTFDVTKAVDLCAAPGSWSQVLAKRLIENGKNSGEVRIVAVDLQPMSPIEGVVQIQGDITENITAKKIIEVFGTLADLVVCDGAPDVTGLHSLDEYMQAQLVVAAMNITTHILKPGGSFIAKIFRARNASLLYAQLKIFFKEVYCAKPKSSRQSSCEAFVVCRGYSPPVGYEPTLDNPMFAANYGEAVNKMNGVNRVVVPFVACGDLSGFDSDGHYDLNLPDIPCGALNSQYVFREVVQPPTEPAYKESVKMKKHDKLAVPESILSKVARSVLPYVKPTNPEAGDIGYGDEQVEALSLLFDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y295</accession>
    <name>A0A0D8Y295_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA / pantothenate metabolism flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH50993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y295"/>
    <dbReference type="STRING" id="29172.A0A0D8Y295"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="29769" checksum="AC4C7723CEF4F86D" modified="2015-05-27" version="1">MPQKFQSVATKVQAFLEINRTNLLAFITSGGTKVNLEKNCVRFIDNFSMGTRGAASAEYLLKAEYAVIFLHREESLKPFSRNFPHIFDSLKVDGYRTDRERYKNRILYVPFATLESYFFYLNEISRQLTPLKKRVLLYLAAAVSDFYIEEEKLPTHKIQSSDGELNLRLSLAPKAIDQIVNNIVPEAFVVSFKLETDESLLIPKARAAIKKYGHELVIGNVLQTRKQHVEQQKNGIEIEQMIIDRLCQRHDIFMKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2Z3</accession>
    <name>A0A0D8Y2Z3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
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        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
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        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0097361">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="47476" checksum="0208EC14B539FC62" modified="2015-05-27" version="1">MSKIDVLSTIHVNTAVEGTVGSRVWMISWNFNGSLLASCGDDKTVRIWKKVKSSPYLECCTKIDDSHSKAVRCVEFSHCEMSKIDVLSTIHVNTAVEGTVGSRVWMISWNFNGSLLASCGDDKTVRIWKKVKSSPYLECCTKIDDSHSKAVRCVEFSHCGRHLASASFDASVVVYSREEGEFSESDKLEGHESEVKWCSFSPSDEFLATCSRDRSVWFWQMDEDEEFQVSSVLQSHTQDVKFVAWHPHEELLVSCSYDSCIIFYRFDGDDWITQQKICEAHYGTVWCAAFDSDGHRLVTVGEDHVVNLWKRDSPEGPAVTDKWRSIAKLFVEDTELPLYTISWHKITGLIASGGGDGIIRIFRVEGSEDDEHIIQTISMDTNANEINCVAWNPTTTSEDNTDSWMLASCSDDGTIRLFGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="34"/>
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            <end position="135"/>
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        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="26122" checksum="9F2FA1602B3A3AF0" modified="2015-05-27" version="1">MKPRCSAEKVGSKTKVRGNAEKIGMKKKPGGGSAEKITLKATQKGSEEKIITRTKLSSNEEKAASKIRAEKIASKAKQGNKGEKLATKAKRIGDGEKVAAKNKPEGAADKIATKERRGGSAEKKAGTKPDANAESIAANFKHRVENVIMKANNKGNIEAAATKAKPSTSDERIGSKTLSSSDRNEEEKIPELKNLEAQLRKTQDADEDKVIDGGAYYSDKGQDDTSADAPSLQINSDPPSKETDS</sequence>
</entry>
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    <accession>A0A0D8Y3B7</accession>
    <name>A0A0D8Y3B7_DICVI</name>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="210"/>
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            <begin position="1"/>
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            <begin position="20"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51180.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="270" mass="30029" checksum="D608EAEDAC04726A" modified="2015-05-27" version="1">MLAMLDGSFHSITGNAVPDETPHSSSRENLGEHEAMYPWRKEQNVIVDDENNTETRTEIPELKEELSVIRQTTLKILSTENPHDDTDNDQLSSTEASPLEWAIPMIPDIKNDHPLEIFVKSTSPAPTLQTASEKSGRRLADQIIDVMTEELTLRPVDDPLLTEASVHAAGAVPVPSFSHLTCINQNAMIALSCVFTVTTLISTVFITYLIRDVCCSWRNTSNHIGRFTAESLHSGCGSELTDESIDRQSDLPIYSRRLGEPSYVITTRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="45"/>
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        <location>
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            <end position="44"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23299" checksum="D5B8ECCB2F05F118" modified="2015-05-27" version="1">MPSTIMLHNISIRKLRKEKKSDKLTNSAGPQINNPNPYNIPSPYGTAHISHIPVAADDPIREQPYSNNPQNRGAVIQSSDIPDVLLSSISAPSLNWSTVAEAEEMKRLMKRHNGKSNHSTRSTSYSSRVPQYYKQLRAINSLTTNLFNGARDPVSVLNDNLYQNEGTSSDDRNPRYASSSNLWIEQKSCFQIISSQYLPCYSIQCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3R5</accession>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5M8</accession>
    <name>A0A0D8Y5M8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5M8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5M8"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF10">
        <property type="entry name" value="GTL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="10">
        <location>
            <begin position="273"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="10">
        <location>
            <begin position="355"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="747" mass="85122" checksum="3BE95C19C417EEBD" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y632</accession>
    <name>A0A0D8Y632_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chondroitin proteoglycan 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y632"/>
    <dbReference type="STRING" id="29172.A0A0D8Y632"/>
    <dbReference type="OrthoDB" id="5822889at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039260">
        <property type="entry name" value="Cpg-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973">
        <property type="entry name" value="CHONDROITIN PROTEOGLYCAN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37973:SF1">
        <property type="entry name" value="DICKKOPF_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336223" description="Chondroitin proteoglycan 3" evidence="1">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34507" checksum="EDA56D97A2BA7C29" modified="2015-05-27" version="1">MLLSIIFLFLVYRISESALPIKEDNDDNLFLSLDQEIEDALQEAFIESPNNLVDETVQHIEGSGSEESSDKIKFSHEDQSVAKFLSETTPDNLMTNEVVQIDNNITFIRNHSSVLKSSPPYPTYLPPPWNYVSVGEINEGSGDSIDEALASIDNTSSETPTSSIITSNVSLEAVLTSTAAYSISLTSYKKKSTVASSTLKKVYSNFHEYNHKGCHVNRTCYRDSDCGKGICLGANIGTCNCHACINNIPCENDDFCGGLNNSCRNGYCKCAEALALHGFPFFIVALKEFCSQRSCNDDSESCFGLPCNHGICSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6D6</accession>
    <name>A0A0D8Y6D6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6D6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6D6"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="36"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="427" mass="49514" checksum="75812374BCA3223D" modified="2015-05-27" version="1">MSRAKLDEPRTTLPESQNYWGFANFPNQVFRRAIKDGFNFTLMVVGRSGLGKSTFINTLFLAEIHDLKEPPQNIGSTVRIEEKHVKLVENTVKLNLTLVDTPGFGDAVNNTRCWEPIINYVDGKFLDFFCEETKIERSDRPVDKCVHLCLYFIEPSGHGLKLLDVEFMKQLHTRVNIVPVIAKADCLTRDELKKFKAQINKDIAANDIKLYKFPEIEDEKDKAVSERLKNSLPFAVVGSNLLKEEAGKKIRYREYPWGVVEVENMAHNDFILLRDMVVRTNLIDMIDVTRSVHYENFRLRQMDKLPKHALDRDPFTQMEEDRKKKEMELAEKKRAFEKTFADRVNERESKINERVARVDIREQDLKKEIEIRKAELDKLKQEVDDLRRGAMTDSKTSLTMTNENSGKSSPTEKLKKKGGTLGLFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6G8</accession>
    <name>A0A0D8Y6G8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6G8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6G8"/>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12702" checksum="ACD56BC5523B3B01" modified="2015-05-27" version="1">MSSQPDAKSKEMDSRTCWSQSAWSRQRKIQLNQKATLLNGIQFDLENALSTVQSISDSETTVEECCEMLRNCIFYKQQLDLDSNKVPDVSARGRSKSLHDVTSQSDDDKLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y773</accession>
    <name>A0A0D8Y773_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y773"/>
    <dbReference type="STRING" id="29172.A0A0D8Y773"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="217" mass="24049" checksum="A19DFCF0004D0512" modified="2015-05-27" version="1" fragment="single">ELNLGKKKKTKKVIKLDDEPAPIQETIADDLGELKLGGRKKKKAKVEEEEEIRSNGAADLGIGIGISNLIDASRAWPDYTYEECLTLVARAGSKKTAFSNFAEICRLMKRQDKHVLQFLLAELGTTGSIDGNNCLIVKGRFQQKHFESVLRKYIKEYVMCHTCRSSDTELTKDTRLFFLQCHTCGSRCSVTAIKSGFTAMVGKRAAARRAAEATAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7I4</accession>
    <name>A0A0D8Y7I4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7I4"/>
    <dbReference type="OrthoDB" id="5875347at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336272" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13641" checksum="CE1496E723E3B608" modified="2015-05-27" version="1">MRMLIVMLCIVTLSTQWIIYRRNHKRKLVCKEDTSLSNTTSLEEILEDAPSMNISRRRRDIEVDPVYTEPIIFIGNNNSLNYMDDGDFDVIAEHLTPEEIVEVKRQIVKTCKALKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7L0</accession>
    <name>A0A0D8Y7L0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7L0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13592" checksum="A86A6E0C79894191" modified="2015-05-27" version="1">MNVLALRVQDIDVKQTLTFCENKVYKPVFFFKILSLDIIMLSGKEVEAMYSKRHHQNSLTLQFDDFIVTAYYFWYLWCHLLSNHYHYSNRSIYSKSNCFLIPVKHVAMKTIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Z3</accession>
    <name>A0A0D8Y7Z3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7Z3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7Z3"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="33540" checksum="42BC08BB6772D56F" modified="2015-05-27" version="1">MRRSWRAMSGPYGQPGYNPQYQNPYPASGPPPPGWSNQGGAQQEFVPPPMPHPNMMGMGANPHYMEGGESDKYNLHFSDRTIRAAFVRKVFFMVSIMWCFLFVYLTLMCCESVRRSFPANIIMTAIFTLAVGYMTMMITVHHNVVSVLLTLIICTICCGSIIIFSSQTKYDLTNMMGIMFILSMCLMVFGLVAMISAIFFKVPFLYMVYAALASLLFMFYLAIDVQATMLMGGRKYEISPEDHIFASVQIFLDIVYIFWMLLSLLGFSKLHVNNNVIHKSHSNYLLRTSFRSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Z9</accession>
    <name>A0A0D8Y7Z9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin autopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7Z9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7Z9"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000002">
        <property type="entry name" value="nuclear pore complex protein NUP98A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="10">
        <location>
            <begin position="120"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="428" mass="48614" checksum="993CCB40C23E8E12" modified="2015-05-27" version="1">MSVVMQALSHRSNSEVEELPKSHDPDELPSCDKRNIERNEVYSPEIDQRAVVIQRGEVRNGEVPRFRLDGSACEDSHISLNRSSEAQTATTGSSSVSCEAVATPQVVASSTTQPIVRLNSPDYFTKPTINAMREMIVNGKVVLNNGLTVGRATYGSVFWPGRIELENIVLDEVVIFRHKEVTVYPDESLKPPLGEGLNRPAEITLERVWYIDRTTKEEIRDSLKLIDLGWRDRLEKVTARMGATFKDYRPATGSWVFRVEHFSKYGLPDEEDDVDVAIVPNGKDVRMTPADISCDVDTSMEEQRLQSYVQRAKVVQVDARNGMNTTNRMQIAINSDVEFANQCIPRMKASYKTSMYEEEFLFNIRVFIAVFEVSTKFFEGLGGKLDTDYDDDDSALDYDMATWRDTEVALHFELIFILLDIKWLVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y871</accession>
    <name>A0A0D8Y871_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y871"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="12506" checksum="D310B88B5530A11F" modified="2015-05-27" version="1">MITESDSFEAKAKAAVESWWRTGLNYGPPVELAPSQENKPSIPFLQMANGGTNKLGCAFNICGDKDDPNSLAYVLFVCKYGEEQIQVGTPIYTDGPPCGSCEDRCYQTRLCKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8T6</accession>
    <name>A0A0D8Y8T6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8T6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8T6"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="331" mass="36999" checksum="4C7F116ECBEC7C60" modified="2015-05-27" version="1">MNKQLLSCSLKGGRQTTTVVASVAADGVDQQVEVSYCDQKVVGNGSFGVVFLAKLQDNNEPVAIKKVLQDKRFKNRELQIMRKLSHPNIVKLKVARHYTKQRQAIPLIYVKLYMYQLFRALAYIHGIGICHRDIKPQNLLIDPESGILKLCDFGSAKYLIKGEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTKEQIQSMNPNYKEFKFPQIKAHPWVKVFRPSTPQEAIDLISTIIEYTPSARPTPQHACLHAFFDELRMPDTKLPSGRPLPPLEMDGEENRTGHGGSDGAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9C5</accession>
    <name>A0A0D8Y9C5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal cation transporter, ZIP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9C5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9C5"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF32">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="45941" checksum="9D7E27FDD3877874" modified="2015-05-27" version="1">MLIISACSFSAPLGMMALPCLSKAIYERIMIFLIALGIGALSGSTMFIMIPQQKNSNVKTIITVGSHPNVTTIVESKDIETKEKAELAANINLGRLDNFLLIYSTVLIVHSSIARLFQIDILGRSRNRYAKQRFRQNEMKRKSTQELDRMLCLIENSFQFSTRHRLAVMSTVDGIEIKNANHKQGRNNNDEHFIDVIHQDLSPVLQSSVKQHHSTKNAPVVYRKGSKDDDQISLSLRIVDKHVIDPSTIEVASVAYMIIFGSSANNFVDGMSMGAAFSDSLLRGLSIGVAVFSQQFPQELGTLAILINSGLGFRRAMLFNFIPIFLSYLGFMCGVLLDNIDEGYDDYIFSISSGMYLYIFLGTLIPEVRDGCNELMKVDIAESLLVTFLQFLGITCGLYFMFYLSTVGNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9E5</accession>
    <name>A0A0D8Y9E5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    <sequence length="145" mass="16702" checksum="F62885F550EE76BA" modified="2015-05-27" version="1">MLPNENFGVRIGNVPDSWVMRIDGMPAVGIVRSKQLDSYLSFDCRLRAFVLQFLILLLAMPNAHSLTYFVGTSVNRMRSPNLNQEEPFLSKDDKQTIVMFCGSALSNPINREKIKDPLELRRICGALIREFKRQRDFEKDKQPLI</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    <sequence length="125" mass="14615" checksum="8B2B100F708BFCC6" modified="2015-05-27" version="1">MNDLIFLTYISTFVQILLLSVTIVLGIFTYRTLKTETVVEIGYVSKLLASTQASITHAEIPFPLLATIAHLYNINLNEFQKLWKHEKDTRCRKVLEVYKKDYLTINFIEKYAKFLRISKGVRRKV</sequence>
</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="4">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YE13"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="10313" checksum="98C512614B272405" modified="2015-05-27" version="1">MISELGNKLFATSEKVGIPSLFNFVVHDPIEITPCTTASTEEKIPQNKNRAREVFTNVSITPGDKNKYKYHSKKSSVAKLSVISPVNAQYAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEG2</accession>
    <name>A0A0D8YEG2_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YEG2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF50">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
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    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
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            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28856" checksum="AEBD427BA263B7F4" modified="2015-05-27" version="1">MISELANFLAFLYFIYYLQEPRRTFFFDAVFPEDCDQMRVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMTGDLERPELQGIIPNSFAHIFDHIAKCQQDTTFLVRVSYLEIYNEELRDLLAKDGHGTNLEIKEKPDIGVYVKNLISIIVGSASQMQKLMEFGNKNRKVGATQMNEESSRSHAMFSVTVESSERGMVTQGKLHLVDLAGSERQSKTGAVGERLKVHKNSFSFVKCSYNKKVHRVSFFRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEK7</accession>
    <name>A0A0D8YEK7_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEK7"/>
    <dbReference type="STRING" id="29172.A0A0D8YEK7"/>
    <dbReference type="OrthoDB" id="5862042at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARGLU1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31711">
        <property type="entry name" value="ARGININE AND GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31711:SF1">
        <property type="entry name" value="ARGININE AND GLUTAMATE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="29999" checksum="77FBB546DE2EAB15" modified="2015-05-27" version="1">MSHPTYCELQSLLMGRSRSRSPRRDRNDRMDDRKKKDKKRRRRDESSDTSESHKLGSILKERSRRSRSISRDRDRDRERDRDRDKDRDKRRPAIPSEVERELTGTFDISSISTEAREWLEERIAEQVLERVKKLEEAMTESQKRARAEVESRLRAQILGEMEEEMASIRKREEASRAKCSALEKELEEKVRQADESEKRFNEERLAMLAERSALERERQEVLREKTALQKNEQLAIINKGGAVRPPIKFSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFC3</accession>
    <name>A0A0D8YFC3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFC3"/>
    <dbReference type="OrthoDB" id="5875501at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="10889" checksum="D1841467B3728275" modified="2015-05-27" version="1" fragment="single">MVDTAMLSEVRLMDRLDYIVNSLPISSITKLSTWTSQVVSNARVGLIVENISELNSLLPIVSSLLLSLSSAISNLFQAFIELYYAIVSMSMQLFEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5K3</accession>
    <name>A0A0D8X5K3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720912">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="37" mass="4049" checksum="4F8968B4070292AE" modified="2015-05-27" version="1">MDCRILDGIARAIPNRTCYTPIPRNTESTGGRICIGL</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7D2</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717210">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="193" mass="22125" checksum="41D8A0D48639C071" modified="2015-05-27" version="1" fragment="single">PKRDLDVDGDNDYYSPTGFNRTYFAREAYQRRRITEAQYCDIGTQTGETIRLRQKMFFGKDSSVCYPMEHGAQVKDPCCDVFERSPNNSPKNVSYLFLTIHFITYTRITVVVEIFTKSYRWPGTFYRQHLKLGEHVTPTTEQDEIVSTDSRVDLRRASTPVLNRVDSGLANAFGCVTSIPSRENSADVGYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Q4</accession>
    <name>A0A0D8X7Q4_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
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        </recommendedName>
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        <name evidence="12" type="ORF">DICVIV_13470</name>
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    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
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    <dbReference type="EMBL" id="KN717105">
        <property type="protein sequence ID" value="KJH40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X7Q4"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="161"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="434" mass="48827" checksum="40DD3359C77EB7BA" modified="2015-05-27" version="1">MSRKRIKQPRQNVPRLALAVPSDTQTALIPAEGCHTPEGPTPSPQDYKQVDKALTAHAWYHGLIPRKEVEDMLKIQGDYLVRKTTVARQVAYCLSVRHVNDVKHVPLGYSAGMWTLKDVTKSSLKELLDTLVQTEKHIPPSGVVLRNPFPRPDYYFLHEHITIIKKLGHGEFGEVNLGKLRLKSGDEIDVAVKILRGTRIKKAQLSAFFEEAKLMRRFDHPNIVRFYGVAPQEEPIMILLELASGGSLKSYCKNHADIPQQKLLQFATDGARGMCYLAARHVIHRDLAARNCLLGQKDELKISDFGLSIADKTEMKLDKLKSVPIKWLAPETLRQGIFSTKTDVWSYGVLLWEIFVQCVSDPFPGETNAKAKEHILYDPVPMVAPAGSPRIVQEVMDVCFAKNPEERADFVKVLKLLSPGEEPPTIPLANFQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Q9</accession>
    <name>A0A0D8X7Q9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calcium-dependent secretion activator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Uncoordinated protein 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_13446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717095">
        <property type="protein sequence ID" value="KJH40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7Q9"/>
    <dbReference type="STRING" id="29172.A0A0D8X7Q9"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000343">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000239">
        <property type="entry name" value="Calcium-dependent secretion activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="546" mass="62789" checksum="00A6D15B906B198E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7W6</accession>
    <name>A0A0D8X7W6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721382">
        <property type="protein sequence ID" value="KJH39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7W6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="17315" checksum="D000E0C20A3EC3D5" modified="2015-05-27" version="1" fragment="single">GAGYSPTAKTIATSSSEIYSSFSSSSPHPTTSFQTTSAFPNTLPHFESTNTITELTTDATTEVSKPSIYSTQPNDQNLITSKTFVPSSSTFETILTSPTTASSQQPSSSSTFVTTPAETPTSKEISSLSTLTQNNPTTPLSTTTTTPADTTLEQLTTTSTWVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8M4</accession>
    <name>A0A0D8X8M4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_14101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KN718853">
        <property type="protein sequence ID" value="KJH39989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8M4"/>
    <dbReference type="STRING" id="29172.A0A0D8X8M4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000038">
        <property type="entry name" value="UDP-GlucuronosylTransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
    <sequence length="297" mass="34389" checksum="3B804DDBE95830B4" modified="2015-05-27" version="1" fragment="single">KWNAVLNERNTTVLVSFGSVAKSILMPDKYKKTLLEVFKTMPDTTFIWKYEEKDSKIAEHLENVHLSTWLPQIALLADPRLTVFITHGGLGSTTEVAFMGKPAILVPVFADQTRNSHMFSKHGGGIVLLKSDLERPQKLRDALNQIFNDSRFAQNAQLLSKILRNQPISPKELLVRHSEFAAMFGSLPNLDPYGRHLSFIQYYLIDIVLTCICIIVIIIYVSIKLLRKCFTLRRKIIRGFTILENMRRKQINTGRQEEEVWWRLILIKLIRRKRKRSVANFSLQQRLSRASSELIKK</sequence>
</entry>
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    <accession>A0A0D8XB78</accession>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJH41027.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10653" checksum="BB140FEAC5C15A00" modified="2015-05-27" version="1">MEMDKLKEAHLNLERDMGEDVFYFYVDNDKLISIMKRIIFRNAAPVLTVRPAPGVELSSKKSNEDGFVFIISKNILFLEPFFLLTQTLSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBB6</accession>
    <name>A0A0D8XBB6_DICVI</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENaC"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
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            <begin position="310"/>
            <end position="333"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="42400" checksum="F7EEC76961A53AEB" modified="2015-05-27" version="1">MRSRIGHVKTDVGHDVIRYLIAGSGFAHVEVYRWNLTYRFELNNLYYQWRGNRTQFDMFDFVFNKNGYKCNEMFLSCHSGPREFDCCSAFVPTYVMLRGRCYRLIEDYYQSDIYLSDNLVVYFNQLQGLLLPITSRPQMIIYLGDEHKEIGLYPRIYLNINNWNNLRFIQRRITMLPERSLCSNDPQNQGISTCFVYNWVNRVMLPTLNCTLPFFKDVLPYTANLSLCEPLTVVFNYYIITSRKYEEYDCLPACERVENRWQMTTSVDKYPLRHYGFVVDVSFYQLEYDHYTETRLITPARFISELGNQISFFIGCSLMTFVQLLFTVMMFIFKHIRKTYHVFIRCIIMARKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBN2</accession>
    <name>A0A0D8XBN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716915">
        <property type="protein sequence ID" value="KJH41064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBN2"/>
    <dbReference type="OrthoDB" id="5875107at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="23561" checksum="37176C6FE8D63317" modified="2015-05-27" version="1">MRGTIGEQRREDNGKHMRDDKKRNNDRDLIEKRVNRLRLAKCVDEMLLVVVAILICGVVYFFLQQQRKALTTDVGEQKEIETATAGGEVKKGDTAKPTDEVATAKVTQDAPSSDVKTAQAINDEPSSDVKTAQQLNDTPTANVETANEDKPQTGDDKKPIETPNKTGSKEDSAKGNNSSKKREKKKKPSRKHKSKKSKEKRKKKSKKTKTE</sequence>
</entry>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716711">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBU7"/>
    <dbReference type="Proteomes" id="UP000053766">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="118" mass="13798" checksum="C44C2521E5C41976" modified="2015-05-27" version="1">MLSTTSILFYCCRNSSRMFLYILGRCRRYIAGILVTFATRIMKRIVDELAQPCVEQSFSHGVSELEELNFINKKGQNTTRSRIQEGLQKLEHSTAKIDWNSPVPSEYYRIYFDDEDDV</sequence>
</entry>
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    <accession>A0A0D8XBX0</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716874">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBX0"/>
    <dbReference type="OrthoDB" id="5870438at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="20100" checksum="84485E3F45A9454C" modified="2015-05-27" version="1">MADQIKIRRRQRKDSIINLQRDQLASTINAAAALSGQMNFGLGGLSLLYNQLKQQVPTQSLLTSPSSSDGSSYSPSNLNPFGTSPDLLRTAPLLFASSKSPPQATVSSGTSPDSTRTTMSNSSSLIAAPVAINPAVQSVFTFPLISNESLIKSLLANYKIFEQTNDFSLVNDSMDTQINNAIIDVCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBY5</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716708">
        <property type="protein sequence ID" value="KJH42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBY5"/>
    <dbReference type="OrthoDB" id="10254927at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="78" mass="8889" checksum="0C41562AE0F2C5D7" modified="2015-05-27" version="1">MVALNLGWNPSARCLSYGFEMHLSRPAISVPLSDREAVLWFGASEADDVVTIEDIFERRPDMLNEADRYLDDCFALCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD31</accession>
    <name>A0A0D8XD31_DICVI</name>
    <protein>
        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="83"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19683" checksum="A54C290715CA4436" modified="2015-05-27" version="1">MIFFCILESRLSLCRPESSEMSIIYSSEGFPVRIIKNNQILHRTSSDAILVQVLSSPGSEHLRSGFVMDRDPQANPKSSSLKQRAESIPRRRITAEKSSVEIAGNGWYDGEDTTRSKEEDIDLDDIPAIGYSGHMPGLRQLSIGKSFNKAAREAKRDHAIRRRAQSSSRGIMRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDF6</accession>
    <name>A0A0D8XDF6_DICVI</name>
    <protein>
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            <fullName evidence="4">4-hydroxyphenylpyruvate dioxygenase</fullName>
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    <gene>
        <name evidence="10" type="ORF">DICVIV_13581</name>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 4HPPD family.</text>
    </comment>
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    <dbReference type="EMBL" id="KN717198">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003868">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:L-tyrosine catabolic process"/>
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    </dbReference>
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        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
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        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
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    </dbReference>
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        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <feature type="domain" description="VOC" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="9798" checksum="CA0CF7B091291F1F" modified="2015-05-27" version="1">MAIKLPINEPATGRKTVSQIQGYVDVDYYGGAGIQHIALNTNNIISSIEALRSRGVEFPAIPKSYYDNLRDRLQHSATKKLGVVEQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDR0</accession>
    <name>A0A0D8XDR0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716739">
        <property type="protein sequence ID" value="KJH41907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDR0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8467" checksum="884715872360BB3B" modified="2015-05-27" version="1">MIEKTATDHHCNHLYLWLGELHGVNAFMKSNSSKGKLFWLSVVVKRLEYPTFVFCPKNADALNYQQLYEGYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDS1</accession>
    <name>A0A0D8XDS1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716760">
        <property type="protein sequence ID" value="KJH41794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XDS1"/>
    <dbReference type="OrthoDB" id="5851747at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="275"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="360" mass="42196" checksum="98B08C492AD7CBC5" modified="2015-05-27" version="1">MTTTSSTVLSSFISLIWLPFPNRITDEPSQNIKLNVWMIQKWRDEYLNWNPRDYGMINSTIIPFKYVWIPDTYLYNSVKMSRDETERYMNIHVESLYWKGENGSMLSFLYPAIYTVICRLNIRFFPYDRQNCTLTISSWTNSKSALDYHADPEVNLASYISNEEWDVKSFKIFRHEVVLLINIVRCYEGNFRFFPYDRQNCTLTISSWTNSKSALDYHADPEVNLASYISNEEWDVKSFKIFRHEYKYACCAEPWTILQASLVIQRKPLYYVVNLIIPTSIITVVSITGFFTPASSNDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIGTLLFHPLVVNDYLRRPDIFLCCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDZ6</accession>
    <name>A0A0D8XDZ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_12035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716727">
        <property type="protein sequence ID" value="KJH41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDZ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XDZ6"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF24">
        <property type="entry name" value="INNEXIN-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
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        <property type="entry name" value="PANNEXIN"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
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            <end position="126"/>
        </location>
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        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="37053" checksum="7B4670F45B3FCB10" modified="2015-05-27" version="1">MYFHATLARSFINALSLRGDDDVIDRLNYYYTPIMLSIACLIISAKQYGGTPIECWVNPHSRESMEEYIESYCWIQNTYWVPMYENIPDDHTTRDEKQIGYYQWVPFILIAEALMFSMPCMFWRLLSWQSGLNIQHLINVACDTQAVVDPTERQKAAIDALSSFFVENLDLQSPNGDVPQRSLIARFKCNRLFSGHYVSTLYLITKLLYTLNIVIQFVILNACLKSDEYLFFGFQVLQDLLNGKPWTESGHFPRVTLCDFEVRYLANLNRYTVQCALLINIINEKVFAFLWCWYLLLVIITSWNRWREADGHSIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE39</accession>
    <name>A0A0D8XE39_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE39"/>
    <dbReference type="STRING" id="29172.A0A0D8XE39"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lbp1-4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="31725" checksum="022DDA74E0CBC194" modified="2015-05-27" version="1">MNSQSIIPDKFFGRFRLEKSENFDEFLSAKGVNWFVRKMIQLASVTKVVSKNETSGYNMENLTSKSNTFYHGWEIGKTFEADGLDGTRHYVTFNFANDTLMENHVRLNDPLDKGETYYYNIDTDGKLVLELPEKFYGKFDLDHSENFDEYLEAKGYGWFTRKLVTFATFKKEFTKNVKPGKFDYANLTSKKNVYYEDVELGKEFIGEGLDSTKHKVTFDLIGNVLFEKHVPIEKGEAKEETYEYSFTTKDGKEFLLVKMEAGGVVGKRFYKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF97</accession>
    <name>A0A0D8XF97_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716902">
        <property type="protein sequence ID" value="KJH41116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XF97"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="15964" checksum="AA2FB75D6AEAD8B1" modified="2015-05-27" version="1">MFNLANLLAWITLNMAVVTSSSIINSTIHFSGSKDVCQIWKNMSEAEICDYVNYHDDICEGGGYLLWTQYVECQTDLTKKITVMISGFFWMLFLFVMVSSAADDFFSPSVSSIVAHLRISESIAYFYCNTLTDGSVLVCEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFC7</accession>
    <name>A0A0D8XFC7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716663">
        <property type="protein sequence ID" value="KJH42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFC7"/>
    <dbReference type="STRING" id="29172.A0A0D8XFC7"/>
    <dbReference type="OrthoDB" id="5862616at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="225" mass="24788" checksum="2DBA2750320F9A7F" modified="2015-05-27" version="1">MFLSTITTQQMMQLNYLKGARLSETSTVKMLSVLKALAQCHVVLGLIMLILSTLADYVSSRINTIRMYGLEECCSFYFIVTGLVGLCGAASYRRGLVITFLVMSIHAIIIFVPAIIIVSSFDIHFYQHECWGECDWHLLATSLPRNSRCQIICGDHVDDNRRVSMTRLGTDYRLDAGLIAAAILELLLALATTVISARTICSTVRGPSMEMVPLNGDSTSVSRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFV8</accession>
    <name>A0A0D8XFV8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716644">
        <property type="protein sequence ID" value="KJH42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFV8"/>
    <dbReference type="STRING" id="29172.A0A0D8XFV8"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="351" mass="38477" checksum="469476AADA6B94B9" modified="2015-05-27" version="1">MSVLSPPDAKKLIEALLCDLRQLSTEAKKKYSHVKEASESGVARVRNISTASGETNLLTNLRAAGSELLHPLILACSTRQTRLVQIALLSIQRLIQHRILEASCANVVVSELWGLVEAECEELRVLQTVPPLVSADLLVTGNALAKVCIVMCFRMHFSKDPVVINAASAAVRQLVGSVFERVIQPTECEIFLSSLMKFVDVDHKGWQRALSLEALHRIIVRQDIVRLDSLERHEAGVLPDGYVVSRAASVLNDFVQTVYATVDAITVEVSSFCSSLVFFSTDETLTEQLLCGLSSLVSVGCKLKIVPASLNCLYVLCCTCLPSITYLHSYAAFEAPKCEDLILCLKTENPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFZ1</accession>
    <name>A0A0D8XFZ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716644">
        <property type="protein sequence ID" value="KJH42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFZ1"/>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="216" mass="24890" checksum="3C849F1A2E4D099D" modified="2015-05-27" version="1">MILSKVKSWLTWSWTYLWALWFLLVIVLIYILRGPLKITESIENGWFSLETSSSYFNNLTPKFYVALTGTSSLVSGVILIFEWCNAVDSVSEDGSDNEDALENQKSIPECKVWRNPMALFRGAEYNRVKTVMDLDPLTYYDMNLSAQDHQSFFTCDEDVGRPDYEIMQIAWRERDSFSRINAAREALRINPNCAPALVLLAEEQCETIVEAEVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG30</accession>
    <name>A0A0D8XG30_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI homolog</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_10336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="KN716539">
        <property type="protein sequence ID" value="KJH43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG30"/>
    <dbReference type="OrthoDB" id="10040378at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF6">
        <property type="entry name" value="METALLOPROTEASE TIKI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="39219" checksum="FFE49FDBA04BAFAE" modified="2015-05-27" version="1">MFQGERNTFLWSIRDPVKNSRGFLFGTIHVPYTEVWDRVMARFKTSLISWAQMQEAPVNESYRKAREIYDNLVGNWDRKRPVWLLFVLYQLCENLLDRPTSPMLDVFLANKAYEEEKQIWAIETAYEQCNPIVSLTQDEIIFAINYTISYLEHLHITQQLFHINTERSVSALVKEYRCGRLDDSHFEINEISISNLHIGEKQKKLAEKIDRQLRDDIIVKRNKRMASRLNQLLTDNPHLTMFSAIGTGHFFGNDSVLHHLKKMGYIVESIREDDVILSPRKHEKKLTFNSLWLRERKTVSTVSIEVIEINTSYKTLSLFSLLFTIVNVELQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGG8</accession>
    <name>A0A0D8XGG8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716529">
        <property type="protein sequence ID" value="KJH43750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGG8"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="177"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28105" checksum="180E2442CB52FFE5" modified="2015-05-27" version="1">MVNFYPAAIESDEEVENDESGEDQDEEIEAVSVVKRKKLSGAASEFSSDFSFDCSLDNDFRQEDTSLEKYLRKEVRSTLEEKIAAMRKHKDSAEVVEAGRNNEVDEVEQLGSQGAVDRLRDRNMVGKKNISEQNTFFKNTLDGNTITFEQMNLSRPILKAITSAGYSEPTPIQAACIPVALCGKDIYACAATGTGKTAAFVLPILERLLYRPGGRPCTRVLVLVPTRELAIQVFQVFRKLSIYSRIEVCLCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGR1</accession>
    <name>A0A0D8XGR1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716608">
        <property type="protein sequence ID" value="KJH42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGR1"/>
    <dbReference type="OrthoDB" id="5843513at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="214" mass="24480" checksum="F22E9EFCAECC0F01" modified="2015-05-27" version="1">MKIQLSYGVLQKTVLTTTKLTESDLKSENNASENTVMSGGNGRKGSSGLLPSLNRIRIQHCFKAARPTIGEAILKRASNNRCEMRILMSRLTDQQIELMGKQFYMLIAYSVENIERVEMIQQHARTLGETYAALCRLGFRPDYFTSLADAAIAECVKLDGGTHKSTYFFNRCETLLAWSQLIGTIFTSVRDGYYSRVRYQRRFVFKIYLFFFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHG8</accession>
    <name>A0A0D8XHG8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XHG8"/>
    <dbReference type="OrthoDB" id="10027016at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022165">
        <property type="entry name" value="PKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051585">
        <property type="entry name" value="STE20_Ser/Thr_Kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46538:SF3">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12474">
        <property type="entry name" value="PKK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="35030" checksum="FBB6C3288EDC3D40" modified="2015-05-27" version="1">MKIMKQEMEMLPRQRRKDAVRIKKDQMEHDNQVKEADFIMQLQKNAENNFARLTQKHKEKMAALERQFLMQKHLLLRAKENSDWELEEKQMGEKYVLHRKLFKDEYFLLRTQMLARHQKELAQAQKINQEEEEELVRALAADRKKLPKMLRNEAKNTQRYSMTPAEMSEKLRRFDEHENMRIRNALEEHDMKSAKKIAQMKERHQQAINELDEMQNEKRKQLLEKERNTMQEHESKYFSMREQWQADLAPRKLLLESRFQEEMEAQERFYGISMSGTIASTPVMPARIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHV2</accession>
    <name>A0A0D8XHV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHV2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26521" checksum="9691FFCABFA19E71" modified="2015-05-27" version="1">MEDLERIKVKLEGKQYSNAAEFAYEMRQVLWRTGESAEDYAYRTVLSYFEKLWSESPEDCNRSARNSTQEGDIKEDDKKLDHYQLLIKRELKKAVDLLREFTVTENYLNFLEERRIEARSKKIEAPSVPTMAILPAEKIFPKLCITDGDILCNDSLISYTGNLGKNRRNTYLAAKEACFGGTREPDNETITLSSDDECLAESNRTLGIENSEEPCTSQKEPENSSSDSLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJI8</accession>
    <name>A0A0D8XJI8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mRNA cap 0 methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN716515">
        <property type="protein sequence ID" value="KJH43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJI8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJI8"/>
    <dbReference type="OrthoDB" id="5836006at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17870" checksum="69B704DB1C4B0AFC" modified="2015-05-27" version="1">MPWLLRLLEELDMELVFMRRFPEAFQHWRTTGMRLLSRMQGLESYPATNGAKLMAEESEYQQAKDFLKSLNPDEHPRIGTLSKSEWEAFSMYLLFAFRKKDTKQQQQQLRNEVEQQPMSSSSATETLAKRKALDSEEADDHILNEKTRKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJJ1</accession>
    <name>A0A0D8XJJ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_10058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716515">
        <property type="protein sequence ID" value="KJH43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJJ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XJJ1"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="264" mass="30182" checksum="DE42FB1C6F0F80F9" modified="2015-05-27" version="1">MLNSHTLSTTIQQQSLSLPQNLESPLNAQMYLLMNVQLQQVINSLPRIDMKLNNNNEENDNNDDKKTMRSFSIDNLLRSESGDDKEKNSYGTSELNVTSYTLDALEVSDRRTKNTKKFAIPRCVCDECGKTYATTSNLSRHKQTHRPLDSEFAKQCPHCDRVYVSMPALSMHILTHKASHKCNICGKNFSRLWLLQGHLRSHTGQRPFGCAHCGKNFADRSNLRAHILTHTGEKRYSCEKCGRRFALRSYLNRHTETSCRLSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKI0</accession>
    <name>A0A0D8XKI0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
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            <end position="40"/>
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        <location>
            <begin position="52"/>
            <end position="73"/>
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            <begin position="93"/>
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            <begin position="166"/>
            <end position="184"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    <sequence length="223" mass="25191" checksum="72404A013DFB41E4" modified="2015-05-27" version="1">MKNSRWNKGRQKADRKSDGVHWHLVRCIGGQIIAAGFVILRFRDAGRVTHTVCYLLLIYHLFNAYISMPIHQSTFNFAFGTTLLPGNKIGNCLYQLDAIASICIGCAWLTFPKWLLHRQVTVPLDLSHELCGRIMGGLFVSSYAVSAHALHWTNTDDKMVAVDGRVVCCLCILSAQVWSQIAYIDSWSGGHWVGITLFSTWTLSSILYRLSLHFIFRKKAKKS</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
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            <begin position="17"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="94" mass="11305" checksum="5B481BA724A40EAE" modified="2015-05-27" version="1">MYNILIDDITERHNQRNLMCTQHLFLTCPYEDHPIVYETYAVERAFVHTDYEYEHQPQDEHKIYIRIFNSGDYMWFYHSSVGSENALVSILNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL15</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
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        </alternativeName>
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        <name evidence="7" type="ORF">DICVIV_08606</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
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        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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        <source>
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            <dbReference type="EMBL" id="KJH45330.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="606" mass="68402" checksum="B8023EE50F6E481A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMD5</accession>
    <name>A0A0D8XMD5_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_10438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH43551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5862361at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8425" checksum="F2E26B48DB7D4497" modified="2015-05-27" version="1">MFVAVVFSGVELHQSKENVEIVPQETCIEHKGPETMRQEQQAVKHRALTGADVQKINDSKHMPYCDRKRFLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMQ2</accession>
    <name>A0A0D8XMQ2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KN716537">
        <property type="protein sequence ID" value="KJH43661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4 6" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="169" mass="18611" checksum="F077697F864FC079" modified="2015-05-27" version="1">MIMSLSDKAPFVMMETSMGKICLELYWDHAPKTCRNFSELARRGYYNGTIFHRIIADFMIQGGDPTGTGRGGASIYGDRFADEISEKLKHTGAGVLSMANAGPNTNGSQFFITLAPTQHLDGKHTIFGRVAAGMKVVQNMGKVDTDNQDRPRAEIRVVKAYPSDDSRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP03</accession>
    <name>A0A0D8XP03_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716356">
        <property type="protein sequence ID" value="KJH46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP03"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="54" mass="6473" checksum="5E8A5A5F2D573F84" modified="2015-05-27" version="1">MRSLNLTKYECLPWIPPSNTCPRRFKPTLNNRRRTLDRRPRTISAYHKWSAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPC4</accession>
    <name>A0A0D8XPC4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 98</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM98 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5978425at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029668">
        <property type="entry name" value="TMEM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335981" description="Transmembrane protein 98" evidence="12">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="23282" checksum="D17A5383C072436C" modified="2015-05-27" version="1">MSYLNALLWLLISQALDKNTWVYDVTGLLQHCVAVLRLCHQLTDHLAAIPLQHASAQLSYMLCQATQRVMPRFDDLLSAVASPAVDIRVLEARATALATVCWALYLPFSLISQKYRETMGDPLRQMDYHLDALRQAADIAERANLGKLELDWSHLDAVAENVAAREATVTKTTPLVDTIEGEANGDNSAKEFNDLMTSVHSNGNHPVDPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPH6</accession>
    <name>A0A0D8XPH6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPH6"/>
    <dbReference type="STRING" id="29172.A0A0D8XPH6"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="346" mass="40031" checksum="410215150E061B4D" modified="2015-05-27" version="1">MFLSYDFVNWLTAGNVKELATRENAIKFASDLVDLEIIEIVRATDVEYDELESCISSESEARLFRYGFQLCTFVDTERDREAPHPSYSRWMRVEFIPNCAPVGPLGECRFKQAAIDLDFAPRDPCPLGEWGRVVYDRSFCELKAFELSIKWFMATGQTVADTVYTWQSKISKERFFLFPVPEDPIALPKDVNSNPLRCPIRVQVNQEAIPSHMLERTLQYLLFCFGFCAMECSVKHVNQVLGSSLASNETSFEGRHSNESSLYIHQTGGMFVSLEKPSNHPPFFFWAWNHMLTRKYRQESQCSEAFQDYMLREFRKYCGNVDNKLYHFYTSVPEAINTADCFFSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPI5</accession>
    <name>A0A0D8XPI5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division protein kinase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716352">
        <property type="protein sequence ID" value="KJH46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPI5"/>
    <dbReference type="STRING" id="29172.A0A0D8XPI5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07839">
        <property type="entry name" value="STKc_CDK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002204">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="33497" checksum="E10990FDD750BFED" modified="2015-05-27" version="1">MQKYDKLEKIGEGTYGTVFKARNKDGGEVVALKRVRLDDDDEGVPSSALREICILRELKHKNVVRLYDVIYSESKLTLVFEYCDQDLKKFFDSLNGHIDQEMARSLMLQLLRGLAFCHAHHVLHRDLKPQNLLINSNGHLKLADFGLARAFGVPVRCYSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGTPTDDSWPGLSQLPDFKPMPLYQPAMTWGQVVPNMSANGRDLLQTKIETVIITTEDTKITILFAHMMTCTIVPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPM3</accession>
    <name>A0A0D8XPM3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol kinase 5</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP:glycerol 3-phosphotransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_08265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="KN716393">
        <property type="protein sequence ID" value="KJH45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPM3"/>
    <dbReference type="STRING" id="29172.A0A0D8XPM3"/>
    <dbReference type="OrthoDB" id="6278781at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07793">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000102">
        <property type="entry name" value="Putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000104">
        <property type="entry name" value="putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037444">
        <property type="entry name" value="GK5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="15">
        <location>
            <begin position="284"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="523" mass="58313" checksum="F5EFE084299B5A0C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR93</accession>
    <name>A0A0D8XR93_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_07632</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716360">
        <property type="protein sequence ID" value="KJH46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XR93"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="24268" checksum="FEB15C5743E0EC06" modified="2015-05-27" version="1">MNVSKIESSRVPTDHDECNAKMTVIDESTKGEKVVFRIPSLATPIQLTNVFSNLQPSSDQVPMSDSDIEAKGDVVLKSCLTSSSGSCHEGLISVLRDDDMFSHDMKAAILNARCDEDMEDNFARRFRLRPSVALIQKQGIVRDRVNLFRQLGNSMPVPLEPISGRSSGLSSRSSLDAASLLGDDELAKPSAPPVTHSLNMGVSKRNSSVSTSLQSFSSSIQSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM5</accession>
    <name>A0A0D8XRM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07496</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16897" checksum="070DCC24B7E8E9F7" modified="2015-05-27" version="1">MKKSLVPSSIHSWGYYRLGYLDHLYDTLLSCFSPLLAFQHCSVLDLFFIVCLSISLRKKINCRNEQKMMDACVEEKLGLTRPKLGYFSKLHVHESIHPRPENKVRDYKAEAAKVLHELPDDYHFRKDYRNYNDWRHKFWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSC9</accession>
    <name>A0A0D8XSC9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716340">
        <property type="protein sequence ID" value="KJH46682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSC9"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
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        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SD17342P"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="68"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15418" checksum="F8389E063BACCCDC" modified="2015-05-27" version="1">MSMPHSKIISLFNNGRSNSTDRSYSLFGAFALSGSYMTDWLEISASILLWMAISNTILYLGAALIALLMMRRHPYVVLFVIPLIAMCVIGPVTVGVTTSLALAFVLSSSDKEISPWHCMILGVFQSIVLIIVSFSRLLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSW5</accession>
    <name>A0A0D8XSW5_DICVI</name>
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            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSW5"/>
    <dbReference type="STRING" id="29172.A0A0D8XSW5"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11515" checksum="1FF2AE1914CDB477" modified="2015-05-27" version="1">MLPQFSNKLQSGTQNFHVGVFRAAAEVKVHPLNLMLPVTITSSYAFVLPVGTPPNAIVFSTGMVSVAEMSYYYHNHNKDEQWDNLPHCEVASRNRITAARPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSY7</accession>
    <name>A0A0D8XSY7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSY7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10413" checksum="EED950E5C56F465B" modified="2015-05-27" version="1">MQLLLNDVIDRTKKNFLKFDKFSAPPHSLQLSVPDKLYLADTGSSNEHTKPTSRTKKRRTVPHQLNSRNEWLLFGDETLFIKYDRIPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT06</accession>
    <name>A0A0D8XT06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenite-activated ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716330">
        <property type="protein sequence ID" value="KJH46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT06"/>
    <dbReference type="STRING" id="29172.A0A0D8XT06"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="33572" checksum="D946A4DDD5BD9A0E" modified="2015-05-27" version="1">MSNHDLEASMKNIVEQTSLKWIFVGGKGGVGKTTCSCSLAVQLALKRRRVLLISTDPAHNISDAFNQKFTKTPQRVSGFENLFAMEVDSNPAEGSAFPGLEQLVNSNGSIASMGRELLQNMIGGMPGIDEAMSFAEMLKLINSLDFDVVVFDTAPTGHTLRLLQFPVILEKAFTKILSLQSSFAPMLGQLSGLLGMGELSLDETMRKFNDTLEQVKRMNVEFKNPDLTTFVCVCIAEFLSLYETERLIQELSKQIADLYEDFHITKLPLLDEEVRGPEQLRTFSRNLIVPYNIAEQKVPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTU9</accession>
    <name>A0A0D8XTU9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716386">
        <property type="protein sequence ID" value="KJH45796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTU9"/>
    <dbReference type="OrthoDB" id="5870055at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="329" mass="39043" checksum="0167B6C98DA5FC14" modified="2015-05-27" version="1" fragment="single">IDYNVRDKEIERQREKQRRREYEQRLNAERREHERRIEAERRRTEESRPIGVLPVIDSRSENEQRRIDELRRRDEELRRSASRRREEERRREQEQRLREEQRRREFERQGQHIRDEQKVFQEQKMKEIDEKNKNKVKTMTVDKSSTYSTKTDDIDEDVELPTLDEWDYKSDEEESTQDYIPGGGQEVGENDLDALESTTALEDTQTSTEQLKTDAVGGITKVIEMAADKTIKMHGSEVDEDRSTIAPSEDDYWDHSIKREDENYRIAEEVDSLEHGDTIHAPMNDGAHKFNAEEGEEGWMMMKRVDDESVAASLSLTTVTLILILRGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTZ0</accession>
    <name>A0A0D8XTZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_06731</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716317">
        <property type="protein sequence ID" value="KJH47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTZ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XTZ0"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 12 15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="14">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="22517" checksum="639B05D4524ABBBD" modified="2015-05-27" version="1">MDDAEKLAESREKKAKNVMREMKIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGPKAEEILEKGLKVKEFELYKENFSDSGNFGFGIQEHIDLGIKYDPSIGIYGMDFYVVLDRAGRRVANRRRAPGRIGPTHRVTREEAVKWFQQKYDGIILPPKPKVKRAVHRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU06</accession>
    <name>A0A0D8XU06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-beta hydroxysteroid dehydrogenase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716313">
        <property type="protein sequence ID" value="KJH47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU06"/>
    <dbReference type="STRING" id="29172.A0A0D8XU06"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="372" mass="42357" checksum="40EDB3058F66A4EF" modified="2015-05-27" version="1">MRACIVGGGGYLGYHLAYQLQSLENHTVLLDIAFPVHPNITLDENLTTRIRGSILDENTVTEALRSCDTCFHLAAYGMSGLQAFDYDLIYRVNVDGTELLLEFCKRMGVQRFVFASTVGVIFTGKELNFATEDYPYPDDSEYISKYCATKAQAERAVLAADCTALRTCALRFRGIYGPGEPRSTDRAAEIIYRGLYLATFSQRDQAITQYSGVHNVIHAMCQADKELSKTQPRCAGKTYHVVDANPVNSFLFWLPLINALSRSPPVIRLPFSLIYFGAYVSEWIAVWFGIPPIMNRLEVNLVGVSNTYSIERAVQDFDYKPTKNHDLTEIVEYYRKYYEENPRSYIWDVRRVFKAFCAFLVLLFIVVKYCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUM4</accession>
    <name>A0A0D8XUM4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716370">
        <property type="protein sequence ID" value="KJH46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUM4"/>
    <dbReference type="STRING" id="29172.A0A0D8XUM4"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000174">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="365" mass="42002" checksum="3741EDEC0E768D26" modified="2015-05-27" version="1">MSDALVYHNGLIVWKPPSIYKSFCPINIEYFPYDSQSCTLKFGGWSYNGFLLDVRQLPSADSPIINREDESGKEYQYLEKGMDLSGFYQSLEWDLMSLTSQRHEQLYPGCCGQDFYIDVTFDIALRRKTLFYTVNLVIPCMLIGRYLLFTMFLVAMSILLSVLSLNYYRRDGSAHPMPHWMQAVFIETLPKFIGIKKAEVDEISDRGSSTSELGQFLDSSRRPSPYFLTVPWSVEDGQKRTRGEINKMRISQLAHLRGMHPDLIRRMIDNVSFIADHFRAMKKEDKISSDWSYVANVIDRLVLIVFTFVNLVGTVLIIQNSPLLFDHSTPMKIGSASRPLSGDTFENAFDANFTQESWWRNSEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUM8</accession>
    <name>A0A0D8XUM8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716303">
        <property type="protein sequence ID" value="KJH47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XUM8"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="429" mass="49270" checksum="1639CFE5807B2CD4" modified="2015-05-27" version="1">MVMEVDEPAGTSMDTSEPFEPSIDWHFSQVKGNIEGDDTHTEADVISCVEYSHDGEYLATGDKGGRVVIFQRDQSGKYVNGARSREYNVYSTFQSHEPEFDYLKSLEIEEKINQIKWLKKKNAANFVLSTNDKTVKLWKISERERKVADDSWNIRRGQYVLIRIAIKKKIFAMIMFVGSLQIPSIVPMELIVEASPRRVYGNAHTYHINSISVNSDQETFLSADDLRINLWHHEITNESFNIVDIKPTNMEELTEVITAAEFHPSQCNWKFSFLLKKVIGILQVWDLNMESRPIEAYAVHEHLRTKLCALYENDFIFDKFECGWSGDDQHLLTGSYHNLFRTYTRGSTDAKTWEARPQEPHSLLRTRRVCAGAGARAQRVRRTVGDAGDDELAADALDFNRKILHVAWHPKENIIALAATNNLYIFSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVT3</accession>
    <name>A0A0D8XVT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716261">
        <property type="protein sequence ID" value="KJH48625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVT3"/>
    <dbReference type="OrthoDB" id="5828333at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="344" mass="39276" checksum="E88119BD7FE8BDC8" modified="2015-05-27" version="1">MSRSRSVFRFAKKKFLECQCKLKRTVKNVSKTSNIVLDEPILEEIFKKLDIKDRVMFRNLSPHIHDLIDRLPLILPFVFIRSDSRGNIELQCDHMDVLLGYILVDIPSFKVNDGVMVFSYSNARTVITSIVSRITGIAHLWLDSTWNGYIVQTIVEYYQAINHDNKRKRSLILTGIDGLEPDDLFRMTNESRLEELAVVGELIKPSIFDRKEAGTMLETVNSLLIQVDSSFSIHDVSEREAILRMMSSLPISGVLEVIHVSRGTVTDTTKVINYWIQLARDSSREVKLKLEECSQERADAAVGRLLRKVRGIGRGEWTKGGVSMQMGDGRLTVLDKRTWFGDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWG6</accession>
    <name>A0A0D8XWG6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chromatin modification-related protein MEAF6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_05731</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWG6"/>
    <dbReference type="STRING" id="29172.A0A0D8XWG6"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PCI" evidence="16">
        <location>
            <begin position="254"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="17">
        <location>
            <begin position="596"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH48162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="812" mass="93410" checksum="7EF120D582D6FD9B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWI8</accession>
    <name>A0A0D8XWI8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">QM protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716340">
        <property type="protein sequence ID" value="KJH46696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XWI8"/>
    <dbReference type="OrthoDB" id="5776427at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L10E"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17403" checksum="0CA8BC3293A8268B" modified="2015-05-27" version="1">MGRRPARCYRYIKNKPYPKSRFCRGVPDPKIRIFDLGKKKANVDEFPCCVHMMSNEREHLSSEALEAARICANKYMVKNCGKDGFHLRVRKHPYHVTRINKMLSCAGADRLQTGMRGAYGKPQGLVARVDIGDILFSMRVKEAVSVFFVVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWM0</accession>
    <name>A0A0D8XWM0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWM0"/>
    <dbReference type="STRING" id="29172.A0A0D8XWM0"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF32">
        <property type="entry name" value="BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="24651" checksum="3DA3C65B1676A330" modified="2015-05-27" version="1">MQSSEPVVSDFWSYITSFQFINDIRDAANEIKDFLIFAGEQFYYTRCERRVVAAQRKDRPELKDGWDVMDLARKFKLPPLIDKMERVDGTTLSIEQFQEKYERASIPCVITGLTESWKAKDNWTIKKLLEKYGNSRFKCGERKNGRAVKLKFKYYAEYMRENEDDSPLYIFDPTFGEVQKSVYLLNKQHYSSEKRFLHSLMRDRVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX56</accession>
    <name>A0A0D8XX56_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
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    <dbReference type="STRING" id="29172.A0A0D8XX56"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="13796" checksum="6D23EA6FADE44C48" modified="2015-05-27" version="1">MKKNYFNRSMKFGWSSRFFFALLLPVLGYEKKATKPKASVWLPLMTLIPTIINLISLILILAIIQHVRKTVGMVNMVCTSSHLLARCAARLSVSPAAKKLILEYAQTRSEFARLLNEDRKI</sequence>
</entry>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
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    </dbReference>
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    </evidence>
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            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJH47371.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
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    <sequence length="199" mass="21900" checksum="FB32A8732F50F2F9" modified="2015-05-27" version="1">MANNHTHMHVSQQQNEGYVKIASLVPQMNSINTYGIVLENHPARRLANGNLVLSMRIADPSGSIIFTIMNAEVQDLFEPGDIIKIKNGFTNVHRGMLNLSCGRQGEFVKSGDFMLIYSETPNMSEFNSEYAAIERARKPSPPPDGEIQSQSSDLRRPQGVRPGMPMHKRPPPSGHQGLPGAPPSKRPDQGGTGLFRGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYF3</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="368" mass="41156" checksum="FAEBFD7126F1D493" modified="2015-05-27" version="1">MFYKVTSSFIYYAILHLCYSAGSYEKPFGCKITSIKDQARQNALDEINTIRSEVALGHFHGSHYLPTAKRMNKLKWDCALEKIAVEAVKNCPRYHSQATSKNGINYHRFQYSVSLSDPIVKAIEVWSDVADVLWPYNNIYNGDTQLLEFANLVFGTTTAVGCSTAKCGNRISAACVFSKPQVKTGTLVYTPGTPCEDDDKCGTSSYCEHGLCVDETKSTEAPPTKNECETKDFNVDFRDTALGMHNNFRSRVARGRARNGFGTYENAPPSSRMDLMVYDCEAEQFAISRVKLCTKKPPALLHWSEYSENFHVLGTTATDILGALQNAISTWTKELEINGIPSNMLYTNELGKRKDKVVTNVTKVSEFH</sequence>
</entry>
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    <accession>A0A0D8XYI9</accession>
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        <name type="common">Bovine lungworm</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716308">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XYI9"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0D8XYT8</accession>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH49798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH49798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="15043" checksum="AFC3D1961E473099" modified="2015-05-27" version="1">MDKRSDRNMLWITLKSKERNGQKLNMFTTSRVLRIIKWKNLETVGHKKLRTAHPQRGSFSVMQWILRPSNVFKPSVKTALYNSPRLTAFSLPEHQIIYCVNVVKKSLKLADSERIPLSKQNRYTEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ41</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ41"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="16160" checksum="896AAF19D3CDAB16" modified="2015-05-27" version="1">MFFYASSNPYEMGFFDILFIISSILLIIMLAIWVCILCRLHIMQRNLPDGIELGYPVYAAQPPHVIYYRADPLERPNRMSSRTERDVHRSNPQTIRHQHYVANRMYPPLYVPYPSRTLCPYFHENYRVAPAPINVTP</sequence>
</entry>
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    <accession>A0A0D8XZL0</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716293">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KJH47766.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="66" mass="7336" checksum="0956E7F1A98C275A" modified="2015-05-27" version="1">MWPTLSLRISVKKLSLKEQLMGETTIGYQLLKIKQINKHTGENIAAKSRSFGGVEVTTAANIKEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZR6</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="31869" checksum="12723E7773170D37" modified="2015-05-27" version="1">MKFEFSHKNFRLGIISKTNHYDLNEADIPPDVVVDAGAVTKYLAMDQIIDLTNLQRYFSCQKDDAIKVFTRTTAPTRWHYGTSENSPNILLVANQGLEVCSLIPFCIMLKFALSLTKTTLRSCENGPKNSGVSEFDYVDSMVHTIFYAQGPSIKTAITLPSFQNVEYMNLWFELLNLRHVANNGSVGFMRQILSEPNTDNERTKFGIRTKNSSSECPFTNEGLLINCGGCSQLEQVRIAKWMNSCTEPRRLLVLLSSSSSSFCYQKYCEKLIITETVKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZS9</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716236">
        <property type="protein sequence ID" value="KJH49382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZS9"/>
    <dbReference type="OrthoDB" id="10552425at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13184" checksum="3139FB18A9E7DFD8" modified="2015-05-27" version="1">MSGQSNCSSLSNGDSSVEFNTFTEDPVLPDDVDREQAESSSLQNTDTSRSRYLPSTNPVPLEETGNQYYGKIMGMDAVSEPYSEDLVMIGSSVDICEVNSSMSVFFFKFMMLLFNEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZV6</accession>
    <name>A0A0D8XZV6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716239">
        <property type="protein sequence ID" value="KJH49294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZV6"/>
    <dbReference type="STRING" id="29172.A0A0D8XZV6"/>
    <dbReference type="OrthoDB" id="5790241at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036708">
        <property type="entry name" value="BipD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF12">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140693">
        <property type="entry name" value="IpaD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="4">
        <location>
            <begin position="386"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="504" mass="59314" checksum="73D45D0650655971" modified="2015-05-27" version="1">MEYDYASTRSRYGEVNAFYPHEKAEFQELNSRLERYIALVKGLERDNAQIVNELRHLHDSWGVQNTEFKANFSKALVMKREESMAALMENAENSIRATRVHAFIDLFNRRIQFIREAELGDRARCAELRSQIAKAEADLEIQMRENSRLAEERAQLNTLNANLYNEYERIWKEVDRIRLELAGFRAREDRLLAEKDFLLKVQEQEVYEIGSLLEESSFDAKKFFENDVAHAIKDIKQEYEESHNRIRKMVTGYYQQKADEVRRISNAKDSDDGKHRANQIANMEKLLEEIRTKFHSLEDRNHMLENEYRQLQHQIRNDEERYETEKRRCDDEYEKAVNSYQRLLIEQGSMSEVALLELEIYRKMIECEEKRLSHRGGIVKVHDSSSKTTKHRTFVGDIRIKDCDENGKHVVVENAGNVEHRMSGYRLSRTIDGHERSFTFPALFVLSPGQTVQVSARSYGHERHGHQHHFEFDDDTTCAVGTHIITRLYNAQGIEIANLELRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZZ8</accession>
    <name>A0A0D8XZZ8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716238">
        <property type="protein sequence ID" value="KJH49344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZZ8"/>
    <dbReference type="STRING" id="29172.A0A0D8XZZ8"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="66"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="29310" checksum="8ECFE38A3A2D0A20" modified="2015-05-27" version="1">MASICQMHKTLLTEWSKEQRNTDTVGQVLKQLGDALFDQTAIGSLDANALTTIYKDYYEISALLAALRNDMPAFDDTIPRVLSFYEQCPSAAENKYLMIGLNLMFLLASNRLSDFHMMLESVPQNIQSNNPYISTPVRLEQSLMEGAYNKVVLTEKTIPSHFYSIFIRIMMDAVRSDIAVSIEKSFKLLSTRDAANMLLFENDVQVQEFAKQRKWKNEHGCFVFETDVAHHEKPILDTTRIAKQTIFYAKQLEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y051</accession>
    <name>A0A0D8Y051_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ephrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716215">
        <property type="protein sequence ID" value="KJH50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y051"/>
    <dbReference type="STRING" id="29172.A0A0D8Y051"/>
    <dbReference type="OrthoDB" id="6250301at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF43">
        <property type="entry name" value="EPHRIN RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="75"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="18221" checksum="46300A67A3E27BA3" modified="2015-05-27" version="1">MLSSSARELGRCISPMKRDKVKVSFRLISPNPSALDYSPGRTYYFISTSTGTVFGLSNRYGGLCASHNLKMIIHVTEKNGDTSGKFLSSVGRHGESTIWSTVSRGERLTLDSDNRRHEYNALSLRDEVDFQIHEIGDKDDLFSSGCCPEILVTVISICVFVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0V7</accession>
    <name>A0A0D8Y0V7_DICVI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y0V7"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
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    </dbReference>
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        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
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    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
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        </ligandPart>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="652" mass="73812" checksum="946286E5BEBE0026" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y101</accession>
    <name>A0A0D8Y101_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716273">
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    </dbReference>
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            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="29551" checksum="9B4CF8F2C455D034" modified="2015-05-27" version="1">MDRISSTGTTTPENPSIQAYTHQTGSTLPFEQAIPMQFHMPFIANPFMSPFMPQHGTNAESAAASSAGANPPLPAFFFSPAQYQEMMQQYFAHMMSANHYGMNVAFPMPFTTAMARPSSQASQSDVCETVNGLHETRRSYTSSEREFSTLSTNCKSNLSSTGNFSLNKTEGGCSEQQYRSRCSPVESNLCETNGIESSFGKDSTKSDGEDVGEVTKKDLERKTSLPASDEKTTSLIRKQMSEIEKEVIRRSQNKNIKKVIFLYTQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SGF29"/>
    </dbReference>
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        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Tudor_SGF29_rpt1"/>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="80"/>
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    </feature>
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            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <sequence length="266" mass="29774" checksum="EF8DACC5C0C45DAA" modified="2015-05-27" version="1">MQQRFHECLPNDFSIACSTLVVAVSIEKVIKKGEQALSCAKNSKKRSRGGGDSVISVSRNVSTTKEHDKHNKGTDTQQHITEQKLKSVGIKKDPKELKQAVKRPTEIKSRGKTIVKQCQVEMPEHEKSEKFMKENAPQLPPLNSVEKLVDVSRRKNSIARIDDKGTKILSAEKKPEGKFEDTQETDFKTAEKVKNESTISPKIDSRLMSKLTNVSLMTERVDPRLMSAVSNFGGNSEVVDRRLMSAPIPLDNITNTDVIMKEAKFV</sequence>
</entry>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="250" mass="28446" checksum="6F7EE4D3CAE7A775" modified="2015-05-27" version="1">MRDISVKYDLILKTYLLFYVSFSSDKNLTFDANVEITIKVIKPTKKIVLNMLNIKLNSLECNKILITGIKAVKIKEVVKYSSLKKISVVLLERLNRNDMINLKMICIGVIGDTLDGLYQTTYTGKDGKLNVRMRIKRFSYFSINCFSSGLLLVTQFQPAYARRMVPCFDEPMFKANLTVGVIHPEGTTALSNGIEISEKPIKIYRVWSSPDLVITTQYALQAGIAAHDFFEKYFVIGFSLEKQGKLLRQT</sequence>
</entry>
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    <accession>A0A0D8Y247</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="Pfam" id="PF17266">
        <property type="entry name" value="DUF5332"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336125" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="204" mass="23288" checksum="21D0811141947329" modified="2015-05-27" version="1">MSNNCLFFISSLFLMFNERFALRKPCQDLLSCSIEKRCLNVPFVADRIQDTEVTEKMYDDIDSAINYGCIFTSGCSRQCKTCTLCHNAKQRVLKVLSGSDPKTDNDHVLVECHELVQCAKTCITGKNISSTSQCLRHHCAYHCFNGSCPKCAAFILKIFNQMCITGDFRNKVKDFQGQCSDLFWEVVHKKFKKEFDLESHSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y255</accession>
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        <submittedName>
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        </submittedName>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FARP (FMRFamide related peptide) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y255"/>
    <dbReference type="STRING" id="29172.A0A0D8Y255"/>
    <dbReference type="OrthoDB" id="5813613at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002544">
        <property type="entry name" value="FMRFamid-related_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051041">
        <property type="entry name" value="FMRFamide-related_np"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986:SF14">
        <property type="entry name" value="FMRFAMIDE-LIKE NEUROPEPTIDES 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20986">
        <property type="entry name" value="FMRFAMIDE-RELATED PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01581">
        <property type="entry name" value="FARP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336274" evidence="7">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="125" mass="14647" checksum="6729211789A0D99E" modified="2015-05-27" version="1">MKRTIVVTVLLTFAVVYAFQDDYQPSGLEKRKSAYMRFGRSAPELVDQLMLNKRKSAYMRFGKRSDPLNLDDEALDMEKRKSAYMRFGKRKSAFMRFGKRSSELEDASDAFDVEKRKSAFMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2R6</accession>
    <name>A0A0D8Y2R6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716253">
        <property type="protein sequence ID" value="KJH48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2R6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2R6"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004988">
        <property type="entry name" value="DUF273"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562:SF9">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31562">
        <property type="entry name" value="PROTEIN CBG18972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03314">
        <property type="entry name" value="DUF273"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25907" checksum="F167AACEA6FB3753" modified="2015-05-27" version="1">MTDTSAVLKCITSENFSNRFRQQSRIAIISIFDDTSYEWILFVDSDIGVVNEKIKIEDYIRTPSDIIFYDRFFNFEIMAGSYLAKRTEFTIKFLHDWANYEKRLPSNFNGSDNGAIHSQDLVSFFFDVSRGASCPELDTYTNMLEGKGWARDAWLTNSHWSPERDFMFHSLKERDREEFTQDAVKKLVPTRDFYSWINTLKTPLDIDLCRKGEEDKQLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y309</accession>
    <name>A0A0D8Y309_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y309"/>
    <dbReference type="STRING" id="29172.A0A0D8Y309"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9528" checksum="309072E79F0AE11B" modified="2015-05-27" version="1">MESLYDRTCSICVQTVSSQFTKYSSIELSYLGDPDDRTLRRIEADFVIPNRMNAIIEKVECHEPYMGTVLTCFFFVLFNLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3C6</accession>
    <name>A0A0D8Y3C6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3C6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3C6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="320" mass="36238" checksum="0B1C279119BD2563" modified="2015-05-27" version="1">MPPTFRVGTFSPPITSVSSLSCLMSINDDTFDPNKLQEAVKVRYLGMQKEKKSGGDDSMNVQFFGRGAIAGIDLNTQKKNNNVFYQAIMEKRRTEEEKLMEKARIEKEKKKERKSAHDDRHWKMKPLEEMTERDWRIFREDFNISIKGGRVPKPLRAWEECGLPEEVYQAIQKVGYSEPTPIQRQAIPIGLQNRDVIGVAETGSGKTAAFLIPLLVWITGLPKLERQEHYDQGPYAVILAPTRELAQQIEEETNKFGELLKIRTVSVIGGASREDQGMKLRMGVEVVCNLELESCIPRAIEVVEAGCLEMLQRNAIVNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y485</accession>
    <name>A0A0D8Y485_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716197">
        <property type="protein sequence ID" value="KJH50804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y485"/>
    <dbReference type="OrthoDB" id="5841292at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="10376" checksum="50BC6640850CBB15" modified="2015-05-27" version="1">MVSTQSVTWTCLLMQLVLSVACLVASMAVIAAKLQSVSIYEDKQHVSIEWWAFSCISFAMILVTIISMFGLSRNKKSLLLPHLLVLICQKIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4E0</accession>
    <name>A0A0D8Y4E0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4E0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4E0"/>
    <dbReference type="OrthoDB" id="5987976at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF320">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26863" checksum="B4B79C1D9618AEFF" modified="2015-05-27" version="1">MELAGRVLGLALIHRCLIDTFFTKTFYKMLLELPITVHDLHEVDSEFCRSLLWLRENSIDMSLGMTFVVNEEDNGQITEKELLPNGAELHVTDQNKEEFISLMVKWRVERGIQRQSQALLRGLHQIIDRDFLRIFTAEQVELVLSGSREIDLDDWRKNTEYRGGYFDEHVVIEWFWDRVAQMSNADRLKLLQFVTGTPSIPFEGFAMLRGSNGPKRFTIERWGEESALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4G1</accession>
    <name>A0A0D8Y4G1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4G1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4G1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="443" mass="50781" checksum="8CF18A9C5F513F97" modified="2015-05-27" version="1">MKPIGVPITTLVCPRASTSIKFVYFVFGILMPLEESQSQCHPLNLPTNSSSFESFSAAGCPSSLKHAQQQSRLLLRNGELFTTIDDHTWKYTFETESYGGIVTGFGNALIPSDDGIAKLVNRKLSIRAITWNINEKPVGALDLLINHMKLAGKLEDMILIALQEISPSNTTFHVDFTMIASKVLHHTHVTYMSYRAWSQMVLIFIRKYHIRFATKPLAKFVSVNTLPKPIRTKGAIGVCFRIYQRWTVIIACHLSHSSLLQRIQDYHKVMKSLKFNTLYSYKGSFNIFHADCVLWMGDLNFRITERNVQWRLHLQRSNSSDIENSIANDELTIIRRKDTKCILELAFNNFSEAPIKFAPTYKFELGTTNYVPNRIPSYTDRILFWTKNASWIECTSYDCIQEKSQSDHRPVYAIFQLEAINEKSPARRNKANQQNYSVNTKSP</sequence>
</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    </evidence>
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    </evidence>
    <sequence length="75" mass="8654" checksum="F891634C138FBC75" modified="2015-05-27" version="1">MVYKQFSENKTRAKHQQHSKPCTLRSSSLMLQTVHAVVHHVFKNTTRSSSANTQINVKYTTKNGYRNIRTNCSND</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF16746"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="145" mass="16583" checksum="3A70E061B2E68BB6" modified="2015-05-27" version="1">MLYSTTFAVTNGRIRIGFNLLITRKVFDLKVLKCDNKNLVFYFINDSVSQIKGSMTTAVLISRSTQFICPDSIDFTEAIKDSPRFRASLAQHMLYFGRLESRLNEILKHVANMMEYSKSYVSTFYASNMQFAKAIIAPMLCDDDC</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716221">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="53577" checksum="A71CCD32F18683A6" modified="2015-05-27" version="1">MSSSIGVFSLGGTFWRNKNTTFANGSKCGTALVNSARYRAGSYFYIHLSIGIALNTVVVQPIDSIERSAIEEQIHRLITAIERYSTELILKKNGLYNEKTCDLIELPAELVCHLYSNCINWKSGNERLKQMALVEQLADANHLNNLAQIQENLVMTWLIADKVEDAYVVDPNDTMGNCDLDIGMKSTDENEIFLIPFFDVSVDRIVYVLKQVTTEKIMQNLISYLRRDASTVPGGFRTIVRAACVLLRAYSDEQLKKFHYDRLKVCIDLDAVLYGRLLDLAHLDIPVDTFRRQEKSVVVRSLVAPGARWTPQLAFLVASLIVDNDIEDCILVETVLNRLQAAQRREMFITLLTFCRQEKKLHRVKNLAMLWARGIDWSLTRFEHVSEALRDEFERWFYFAISCPIEGGRSFDSIRNILRARNYVVAAYLIGVVGSFTQKCSSLDFATVNPERELVFKWVTSANDRVLTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y675</accession>
    <name>A0A0D8Y675_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y675"/>
    <dbReference type="STRING" id="29172.A0A0D8Y675"/>
    <dbReference type="OrthoDB" id="5844535at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17538" checksum="8B83F2FD20ADC291" modified="2015-05-27" version="1">MNFLVRKAIEGEYRIGKHGIGERDENGNRLAGLLSTARLFHGNSFFQKKERLRWTWKSPDDTVHAEIDHFLTNRRWCLFDVSVLPAFPSESGHRLLRAKVRLSKTLEEEWLKRKKKVNDENIPDDVLQQLVCHVEEKLSYNSKHVDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6C3</accession>
    <name>A0A0D8Y6C3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6C3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6C3"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19870">
        <property type="entry name" value="DSRM_SON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21182" checksum="6BF016621E6550F3" modified="2015-05-27" version="1">MGRWTLTCDWNRKTCSVMLFRFFTTFRIDGRRKDMFKNTRPKIGGVGMRLMQKMGWRPGEGLGPDGTGAIEPLVIDVKNDRRGLVSQEDHSSKYSSAPSTSDVSVTKHPVSMLMELCAKRKWATPTFNHTENGPSNMREFRCSAVVNGIEYQSNVVSRSKKDAKSIACRVVLQSLGLIPRDPSLPVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6F9</accession>
    <name>A0A0D8Y6F9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6F9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6F9"/>
    <dbReference type="OrthoDB" id="5920520at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF377">
        <property type="entry name" value="COLLAGEN TYPE IX ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="29210" checksum="ABF26FF6F1FB1F81" modified="2015-05-27" version="1">MNVEHRIKAYRIVTYSAVTFSMVAVISVCTTLPMIYSYLRYIKQYMQSEVNLCKDSARDIWSEVGNLKAVMKQYNRTVRETSSETCQECCTGGPPGPPGIPGQPGRPGNPGAPGIPGKPGRPPSQPCEQVPIPPCKPCPPGRPGPPGPAGPPGDPGANGNAGVPGEDGQPGPQGPKGLPGPAGKNGSPGSPGLPGMNAQSVPLLPGPPGPPGPPGPRGPPGINGTPGRNGPPGKPGEKGPPGENGPPGEPGNAGRPGQPGLPGPPGERGICPKYCSIDGGVFFEDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6J3</accession>
    <name>A0A0D8Y6J3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716213">
        <property type="protein sequence ID" value="KJH50186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6J3"/>
    <dbReference type="OrthoDB" id="6278121at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336239" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13822" checksum="B31C8C919EFFD021" modified="2015-05-27" version="1">MNMLWLVTMVKMMVIVDFVAAFECYTCNPRKGHRCVEQMPKGTRSDWSTRSSPAPPSQMAPTLLCVCTLPLCNAGHFSTVVENTMLNHLPRQLLPSREEKKVAVNSVRDHPAYGLAEQLADAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6T3</accession>
    <name>A0A0D8Y6T3_DICVI</name>
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            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y6T3"/>
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    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
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    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="246"/>
            <end position="266"/>
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        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="363" mass="40849" checksum="8D17E4490D8799C8" modified="2015-05-27" version="1">MPLSSSSCSVCGSKQTNVVDGLMYCDICGTQIFTYCELEADDDGIVVPRARIAKHKTINLPSPSNEKSDEAAPDLSTPRAPKKRKMSFIHFLGEILKSNIEGYMEHDDLDVPSEILNDVTSGRSHVPSYLGRIGIRISTFTKILAKGVVMILKDGDVPSVFPDHVFSLYQRYLSACNVAYTSNDYTDDLEKMFRALLVNKKLSQKREKGKKRKKEMRKMKAKEVLEKSVTAWDLLMSSTLDENLELHSDEEQQEVEDSKKASTSRSHIEPQLVEVVNTTIPKEILNHAMSCYLALDVLVALLFISLVTIGCKWILLSDIVRWVREGRSQISVFQLSALRTGKLEEAMTAKSWWTNMVLCSELC</sequence>
</entry>
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    <accession>A0A0D8Y7Y2</accession>
    <name>A0A0D8Y7Y2_DICVI</name>
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        <submittedName>
            <fullName evidence="4">BTG family protein</fullName>
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        <name evidence="4" type="ORF">DICVIV_01688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716170">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="19928at2759"/>
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    </dbReference>
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        <property type="entry name" value="Anti_prolifrtn"/>
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        <property type="entry name" value="BTG-like_sf"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="88"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="204"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="215"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="258" mass="28761" checksum="280874C67D8AEC37" modified="2015-05-27" version="1">MFIEIEETVCFIASFLYGKIPRSRIDSFAETMANGLVDRVYIRSEPLKSYSLVVNVDDNKDNLIEEAAACAFISLSELGKLLPANLLLELRDGSVHAVNADTGHVKCIYPAQGCSTVNRRNGRRIITRPIDVRRRPCFRVEFAYPKGSERDERAVAKPNFESSQGGESGYGHHPFTMPSIYAYLRLLAFLNAIACATSMTMQKNDGNVNVKTPQKTTDEFSDDEKKRLSEDVQGDRSSSGFVDDDELSDPVNEKSEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Y6</accession>
    <name>A0A0D8Y7Y6_DICVI</name>
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        <submittedName>
            <fullName evidence="12">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
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    <gene>
        <name evidence="12" type="ORF">DICVIV_01037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Synaptic cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7Y6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7Y6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
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    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="16306" checksum="9E2A7F6EAFC2F89F" modified="2015-05-27" version="1">MRSMMIDAEDRLMVDLFKGYNSLVQPVRNKSELPMIVKIAMQLILLINVDEKEQVMHTNVWLTLKWQDFQMRWDPSDYDGITQIRVAPDKIWLPDIVLFNNADGNYEVSFMCNALVHHSGEVLWVPPAIYKSSCIIGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y820</accession>
    <name>A0A0D8Y820_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spectrin repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72928" checksum="AF32DA2D7FE501C0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAZ6</accession>
    <name>A0A0D8YAZ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAZ6"/>
    <dbReference type="STRING" id="29172.A0A0D8YAZ6"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
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        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="21909" checksum="5CD8DC5FE67E4B5E" modified="2015-05-27" version="1">MRCRPIVLSGPSGGGKSTILARAMSDYPDRFTFSVSHTTRKPRVGEKNGIHYWFIDHTEFQRMIANGEFLEHATFGGNIYGTSKKAVSDVEETGKICVLDVELQGVRNIKKTHLNARYILIRAPTLEILESRLRARGTEGEEDIKRRLKHAKEDLDAVEEDPGLFDHVIINSNLEHAYKEFIDVVADDLLDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB32</accession>
    <name>A0A0D8YB32_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB32"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="10928" checksum="1110E54BFCF51DE9" modified="2015-05-27" version="1">MTRTMLYYHWNYLYKTRVRTEGRNKPKSSATFFIIQRYDTVFSVTSSPHPLLSHATKRGTHVKVTTLFLPTIATYIKRCYTTDLNISLLAVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBW8</accession>
    <name>A0A0D8YBW8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ligand-binding protein, receptor family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_01773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBW8"/>
    <dbReference type="STRING" id="29172.A0A0D8YBW8"/>
    <dbReference type="OrthoDB" id="5813655at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="137"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="447" mass="51264" checksum="57C3BB75576719E5" modified="2015-05-27" version="1">MAYRLSSESLKVDVTPPSNILIEPNMRHGFLSEFLTILQLLRLVECQSSNSNDAQPSVGLLLDPNTTNDNEILISYLAAVSRLDEQPEEFMKAISIARTRASESSSSSSPFHDERFKQIYTMFNCFSTDFDGSMISGALQVAVDEINSDPNLLPNHKLTYIFDNTCGKEKKSTQYFMDHWKMGARVFIGPEMNCRTEATMAAAQNLPIISYKCKDQTVSDKKKYNTFARTVPAETDIVKAFIALCREYKWKKFTIIYEEHPAHEELYQALQQAIDVENARLELDEIRYSVQNVSKVIRFSEVQSEKLIDSVIEQTKDITRYTMIDLQSSWDVSNSSDHQIIGYSRAALAIIPTPVELNSERFKRFWEQAVKDLVNFGITKHEHTWSIKVNRFACYLYDAIYLYARALHELIEETVERQAHGYDPTRDGAAIIKKILNRKYSSMLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC15</accession>
    <name>A0A0D8YC15_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC15"/>
    <dbReference type="STRING" id="29172.A0A0D8YC15"/>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF172">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="161"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="400" mass="44732" checksum="CBD97CFCFDE5D7F3" modified="2015-05-27" version="1">MIAESESHSFTLSDLTPNTLYQFRVRTVDAFTMGEPSSPSTWVKTPPAAPSETIDGLRWKSLDNNTIFVEWNPVETSHQSGDHLRYRLSWSMEDSDQTEDAKTPERKFLAHHIDTKSPQAIVKLNTSRDCRMLVLSVRPMNDQGAGLISTDTVAFVHRNVEPRHLSFVNASALNSTHALFSWEWEEENECGRAHAIQLSCSSTDNQSHDVTVLAEFSEWILGELNASTKYQCFLTPVDDEGNYGVASKPVTINTKQIPPTDAPIIKKISLKPTNNDVGYTTIIEWSAIEFPHTNWTDTVIGYKIFVYVSETASEAVELTMPISDLSNPRQPSARLDGLKLMYMYTIQVAGYNSGGLGPLSASRTIRLGPRSSLDDDSSSMAYHLHPAWISFIYLVIILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFJ0</accession>
    <name>A0A0D8YFJ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sushi domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8YFJ0"/>
    <dbReference type="OrthoDB" id="9991441at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336533" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="10">
        <location>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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            <dbReference type="Pfam" id="PF00135"/>
        </source>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="40" mass="4921" checksum="20D8DE170F066860" modified="2015-05-27" version="1" fragment="single">MYYFNMRSSANPWPEWMGVTHGYEIEYMFGQPFFMPSVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7D6</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717198">
        <property type="protein sequence ID" value="KJH40460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7D6"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="6">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716789">
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335626" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11896" checksum="15E9161442099831" modified="2015-05-27" version="1">MTYPSVKIILICLLFTVKVNETKPLIELFKSLTEKQTEIKNQKLMQFISKSVPYGIDPSLSDGEAFQSDKSANFIHDGRGHVVFRQFRRLRLSDVLHRRGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB55</accession>
    <name>A0A0D8XB55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5832334at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335642" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9863" checksum="9B6A4202C12ACFCE" modified="2015-05-27" version="1">MRFHKMQQSFRWPLLALILVVLSTIQTQASYREIDRVLGGRIERNCFFSPMGCMFLPSKKFSRVRRLPFPREIIPKKFWSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB91</accession>
    <name>A0A0D8XB91_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">CC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721170">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335479" description="CC domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6442" checksum="B7A6FFC9DE455960" modified="2015-05-27" version="1">MIMNLKVLLLIACLHLVQTQLEMCLNGGYGPCLGDLCPLAGSRCITTANGRLCCLNQFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBP2</accession>
    <name>A0A0D8XBP2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719486">
        <property type="protein sequence ID" value="KJH39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBP2"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BICD"/>
    </dbReference>
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        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="27139" checksum="93110B4926682384" modified="2015-05-27" version="1" fragment="single">MSKLNITYSGELDFRHVRQQKDVVLDRLEHLLKRENIDSNVDRRDHDQRADIRTLLLFAGEKAAQLAAAAQDIMIQVSDQLFQFYSQIVQNHGFTTEKSLIEIVNTLRQLARENAEDLPKISLVDEGVESGPETDNSSAKAIPLNSDRAILSSSFIRDVDKRLSSCKIVDAVSESDLRQRILTDGSALCQTSDCLKKLLTTVKRTAEQALNQAVAAGGAETDDILMQNMKLRSLLSIKRSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBW5</accession>
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        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_12805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716876">
        <property type="protein sequence ID" value="KJH41227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBW5"/>
    <dbReference type="OrthoDB" id="5870289at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709:SF15">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46709">
        <property type="entry name" value="PROTEIN CBG23488-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26482" checksum="17C8EFABF5D84032" modified="2015-05-27" version="1">MKTYNVHMLIASRIVQLCIPYILIANTAFRLACITERTVPQIRGRNLQLTVVIITAIVAFLRLPGYFFIEVVILPNCDLFQSRILSGKEVNPQIAKMYTISDVFIQTRGNDAEQEERREYKRLRCAVKTTIVIISSYLACNSVNFVLYCIEIFKSNLTQDEDGNFNVFYVIASDLGTNLFVFSSTIRIFVYYKYNPTIRQQIQSVTNPRCLIGNKETYHRKHKPLNASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCB3</accession>
    <name>A0A0D8XCB3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716690">
        <property type="protein sequence ID" value="KJH42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XCB3"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7578" checksum="91554C5125BD1318" modified="2015-05-27" version="1">MGSRYEHSYGSFASGISTPGGLSDMYGVPVEKTQGGLETLQEIDTPKTSNYNFLSSPDKIRPPSRISTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCG6</accession>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <comment type="cofactor">
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            <name>Mn(2+)</name>
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        </cofactor>
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    </dbReference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717406">
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    <dbReference type="Proteomes" id="UP000053766">
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            <dbReference type="EMBL" id="KJH40296.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="181" mass="20233" checksum="870AEA822C36989C" modified="2015-05-27" version="1">MVIKIISEHSLASNVNLSTTADDLSKMGRMLKQIHHRETSVHSMPQVVKDKNGTPTRQQVDSVTAQPIQGLKLHQKHPQNVGQVHVLPMKREKTQSNYDQTKFDQNSPSITLQRVQPTYDQSMHSMGPSLGGTKQLSHALVQAVYSQAAPDETLPQSQPIYDQPKYIQNHSQACSQQFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716763">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF3">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17100" checksum="913FC0F706465FB0" modified="2015-05-27" version="1">MNSRVSGDVKAVDVRGNTNPIRFSYSSVRLPYVNDRVQHPHSIQYFYLCLESCEDKSLLRHNILSSRHFMYHQLTILSVLVQFISSEFTPHFRKFLHESYGVGIAGTLERTDLGLDASLGGMQNNNDVPKKQAVILVHGVTNKITRFMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEJ6</accession>
    <name>A0A0D8XEJ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GGL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716601">
        <property type="protein sequence ID" value="KJH43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEJ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XEJ6"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="6">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8994" checksum="EDE990B41558B678" modified="2015-05-27" version="1">MKFYRMSGREQAVHQAMRAVEQLQGERNMQRISVSLSSADLIRFTQDLQREDVLLSGFPNDKMNPYRPKSSFQCNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEU6</accession>
    <name>A0A0D8XEU6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716951">
        <property type="protein sequence ID" value="KJH40961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEU6"/>
    <dbReference type="STRING" id="29172.A0A0D8XEU6"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="268" mass="31110" checksum="FA115E65CA5EA350" modified="2015-05-27" version="1" fragment="single">FFQRWYDEFLYWIPEEYGNISELRLPYDSIWLPDTTLYNSLVMKDDETRRLLNAKLTTDRNRRASLIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQVGIDYFPYSDKIGTSNYIENEGWYILKTKVVRNEVKYTCCPNKYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGVREEKVSLGITTLLSMSILMLMISDQMPTTSTFIPLIGWFILAMIIVISLGTIASSIIIAIQKRGSLGARLSKRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFA8</accession>
    <name>A0A0D8XFA8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716672">
        <property type="protein sequence ID" value="KJH42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFA8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13321" checksum="47B48FA64EAC7BEC" modified="2015-05-27" version="1">MVGNPNCNVKLRLFCRTYMPAMNGNITNRYIWSQEGIAQSQLLSAYLQNFNDIYFKQNHNEICECHLKLWSDNFYTTTVVTFTLLVSGTLAIFYLWGRHIFEIKGPYTYSRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFH5</accession>
    <name>A0A0D8XFH5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="KN716662">
        <property type="protein sequence ID" value="KJH42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFH5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFH5"/>
    <dbReference type="MEROPS" id="M12.A45"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF880">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="23338" checksum="A11DC218AAA4244D" modified="2015-05-27" version="1">MLESNEESTCMETHIVQHELLHAIGLWHEHMRFDRDRYIRVHYENIRPGFESQFSRIPSSQSTTYNLPYDYKSVMHYGKTAFALPGRISMETFDRKYTNVIGQQHDASPSDYLKVCKIYGCNRCNGGSVTPGGTDEEPDPWNPKPKPVSPDDGKCMDKIPQLCAALHLSNVLNCNGNGKNYCCATCKRRGGDSSGSSYDDDYYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFR6</accession>
    <name>A0A0D8XFR6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716651">
        <property type="protein sequence ID" value="KJH42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XFR6"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000068">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="446"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="12">
        <location>
            <begin position="843"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="983" mass="112244" checksum="0D89B391F41E95C5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFR9</accession>
    <name>A0A0D8XFR9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="KN716648">
        <property type="protein sequence ID" value="KJH42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFR9"/>
    <dbReference type="STRING" id="29172.A0A0D8XFR9"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26522" checksum="61CEA0D287C54878" modified="2015-05-27" version="1">MVAFNHVISHVIFDFDGLLVDTEPSYTLANQVMLNRFGREFTMDIKAKMMGRKNMEAIAWLLNEVSIADQITPEEYAIDYEAMLEEMFQKCTDLPGAERLVRHLAKNEIPMAICTGSCSRTFALKAMNHRQWIDLIPLQVYSGDDENIKRGKPYPDAFLETMRRFPIPPVDPSHVLVFEDAPNGVRAALAAGMKCVMVPDKMFRNDAETLRANKVLDNLEEFKPEEFGLPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG20</accession>
    <name>A0A0D8XG20_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716853">
        <property type="protein sequence ID" value="KJH41311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG20"/>
    <dbReference type="OrthoDB" id="5859073at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="382" mass="44041" checksum="54F3B1864A9F5E56" modified="2015-05-27" version="1">MSKSPFIRSFYCSPVSKTVQPDLHSTEVPRKDVRHDQQNTAVIQYPINPPRVPEHYFAPKPFVLNKPLIESSYCWAYGVEEYHKIVKSSKCEDIQHGLPVNDRLDVPIVKCSDMGDGQGNVFREPYQPYKATSNCQSTTFHRNTNERRLIDEVEMSYNQKDTNEERHNQKSFETSEYAWLRLDKEREELYGIHRNYEPVAERSINYTQDHKIVPDIEDDDWNKNGLVNEKKNVAVSNVKPMTQEESDYLGFSNDLYPAYCLNKTTLYDTHTTSVDDTQNRSPRSTLCRGAEPETNAPDVVQPTSSSAFHNDTRSGADDYDTAVETPKYLSRFKTVIKPTIQKQHYRTQYSPIGNAFDPVGQMQLSEYHFEDLNDLVSCIGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGM7</accession>
    <name>A0A0D8XGM7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_10182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="KN716525">
        <property type="protein sequence ID" value="KJH43810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGM7"/>
    <dbReference type="STRING" id="29172.A0A0D8XGM7"/>
    <dbReference type="MEROPS" id="A22.009"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
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        <location>
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            <end position="89"/>
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        <location>
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            <begin position="145"/>
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            <begin position="178"/>
            <end position="196"/>
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            <end position="426"/>
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        <location>
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            <end position="451"/>
        </location>
    </feature>
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            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH43810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="465" mass="51683" checksum="7B68A79858B96B62" modified="2015-05-27" version="1">MSSTPETGMLQNDMSSILRITPVSTTVTVNSYGPIVSTSVEDSAVPEQGEDQEEEAELKYGAGHVINLFVPVSLCMVMVVFTMNTVTFYSQNDGRHLLYTPFVKETDSASEKVLMSLGNALVMLCVVVVMTVVLIFFYKYRCYKLIHGWLMASSCLLLFLFTTIYLQEVMKSFNISPSVFTVGFFLGNFGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWSVLAVISIWDLIAVLAPNGPLRILVETAQERNEPIFPALIYSSGMMYSFIFNGALEGEANSTNVQPSVQASSSEESTPSTSGLLTHSSSSVARVRRFAPQRNPVVGNLSQEAVRSLNDAPILTTPRVQPNLVPRDQEESKRNGIIGGVKLGLGDFIFYSVLVGKASSYFDWNTTVACYVAILVGLCFTLVLLAVFRRALPALPISIFAGLLFYFSTRWIVTPYVSELTRRQWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHC3</accession>
    <name>A0A0D8XHC3_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_10838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716587">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="249" mass="29004" checksum="DBCEFC55553C42B7" modified="2015-05-27" version="1">MSTTSLACWMAKLPSDMAARPLCLLKIPGLPFSSLALRTEYTRSITAGCRVFSKEYKGDVYVALLLHLYSHFYDIGRVFVIIYYLLQVVFLDMNHLFNMDELTYRKLQNETTTILGRNQICPFMNSNMVSLDFMWSNGYRHDNLFFFAMKFLKYFPLQIPSTFCHCFRVIVFTSFIETNPTIFWPATTICSPWPNTNKINNLLDILSFNLEHRQDDTFKFFVTQGVCTPRVSDVDYGIGHSDDTIYKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIS7</accession>
    <name>A0A0D8XIS7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716694">
        <property type="protein sequence ID" value="KJH42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIS7"/>
    <dbReference type="OrthoDB" id="5862048at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="12556" checksum="63742886DFA525DE" modified="2015-05-27" version="1">MNIRQHTITEASRHSFQFSVGTLPTLSVLASSSFSQGGTAMSPTGKCCMPGYEAERDKLREYLGIEWIPGGLKQSVKPRQFNPRLSPIITLKTLIILNNENMKLIGYCAIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIZ1</accession>
    <name>A0A0D8XIZ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716529">
        <property type="protein sequence ID" value="KJH43744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIZ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XIZ1"/>
    <dbReference type="OrthoDB" id="10058785at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
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    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="25183" checksum="D40C1226789096F0" modified="2015-05-27" version="1">MRHTDVLIDIYLYRCRGGYPIEAWRYFMLHGVCTGGHYAEKKLTDEYQYKLSQEKLLRMFANHMPFILVVIIVMRYIMENAPKKYSQHHNVHNHAKPDMLVIMKTIKFTARKSAYALPNNEKAIQREIMTNGPVQAAFMVYEDFSRYRSGIYVHTAGRREGGHAVKLIGWGVDDDGNKYWLAANSWNSDWGENGYFRIVRGVDHCGIESAVVAGMPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ92</accession>
    <name>A0A0D8XJ92_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRPM SLOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716522">
        <property type="protein sequence ID" value="KJH43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ92"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ92"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335818" description="TRPM SLOG domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="2">
        <location>
            <begin position="201"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="436" mass="48146" checksum="8AC33D11F766EB93" modified="2015-05-27" version="1">MALIAFRFLQALDSMLTTHLLCVNVRTLSLGSEKLSVPRNSICGECTIGIRSSMRSGEVSRKSTNRLFENPNLFARALSEKLTGPWIEHAFQKRECVKFVAQKDYPDRCGCGRLMKTHSQLALSRFSVYSPTARPEDDGPWSIATHTQTSPTDAYGTIVFQYLPIGGAHAHKAHFIRLGYDSDPENVMYLMEKGGAHAHKAHFIRLGYDSDPENVMYLMEKVWGLQPPRLVITVHGGMTNFEVNEKLGSLFRDGLLKAAQTTGAWIITSGLDSGVVRHVAQALDDAGISARMRSKIVTIGIAPWGIIRRRERLIEKDGQIQYDPHSFGSIAGLGVLNDRHSYFLLADNGTSSRYGADLYLRQNLENFLANRADGDGTRKVPVVCAVLEGGTSSLIAVHQYLTQEPNIPVIVCDGSGRASDLLAFASRYLDADEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJE0</accession>
    <name>A0A0D8XJE0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716664">
        <property type="protein sequence ID" value="KJH42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJE0"/>
    <dbReference type="STRING" id="29172.A0A0D8XJE0"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036465">
        <property type="term" value="P:synaptic vesicle recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08833">
        <property type="entry name" value="ArfGap_GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032352">
        <property type="entry name" value="GIT1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF3">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16559">
        <property type="entry name" value="GIT_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="12">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="767" mass="86776" checksum="AEF550876633260F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV3</accession>
    <name>A0A0D8XJV3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mob1/phocein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716443">
        <property type="protein sequence ID" value="KJH44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJV3"/>
    <dbReference type="STRING" id="29172.A0A0D8XJV3"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="21302" checksum="DB36765821D00813" modified="2015-05-27" version="1">MLQATPTLGSGNLHEVVRLPDGEDINEWLAVNIMDIFNQVRMLYGTIIDHCTNEACTQMTAGPAYEYFWTENDRVLSCPAPVYIDYVMTWVQDQLDDEYIFPSQIGRSFPRNFIEVCEGIMRRLFRIYAHVYTAHAARFSELKAAAHLNTSFKQFILFARQFQLIHAREFEPLRMKIEELIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV5</accession>
    <name>A0A0D8XJV5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome subunit P45 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716646">
        <property type="protein sequence ID" value="KJH42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJV5"/>
    <dbReference type="STRING" id="29172.A0A0D8XJV5"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="417" mass="46900" checksum="59A759246EF904C8" modified="2015-05-27" version="1">MAAAALPAIGIFDDIEKVVAQVSINEQHPKDSLDSESDDYLKLKKLENELDHLQVMEDYVKLETRNLEKELLHAQEEVKRIQSVPLVIGQFLEAVDQDHAIVGSTTGSNYYVRVLSILDRELLKPGCSVALHKYSNALVDVLPPEADSSIQMLRPDEKPDVSYADIGGLDMQKQEVREAVELPLTHGELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAANTAASFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENSPSIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQSTNVKVIMATNRHDTLDPALLRPGRLDRKIEFPLPDRRQKRLVFTTITSKMNLSDDIDIEDYVARPDKISGADINAICQEAGMHAVRENRYVVLTKDFEKAYKNVIKKDQNDFEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJW6</accession>
    <name>A0A0D8XJW6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_09835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716496">
        <property type="protein sequence ID" value="KJH44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJW6"/>
    <dbReference type="STRING" id="29172.A0A0D8XJW6"/>
    <dbReference type="MEROPS" id="M10.068"/>
    <dbReference type="OrthoDB" id="7550572at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="93"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28727" checksum="161B26626A13A598" modified="2015-05-27" version="1">MKKIYNSVETPHLSTSSSSIHYKSYLHRFGYLSSPSPSLHEFREALRLFQEVIGVEASGELTLETIEATKKPRCSHKDTRKQTSRSKRFALASTSKWDKKHFTGLHELSLKWFVSEYTNDIPKAIIRSTIQKAFQLWAKQANERNLPKVTFRFEEAQSQADADINILWAEGAHGDQYEFDGASAKKNILAHTFFPGHSEPLNGDIHFDDAESWEADSDAATNQGGPDYVNSDSVEKEFNGVMKEIFKLKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK41</accession>
    <name>A0A0D8XK41_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716437">
        <property type="protein sequence ID" value="KJH44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK41"/>
    <dbReference type="STRING" id="29172.A0A0D8XK41"/>
    <dbReference type="OrthoDB" id="5850198at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24222:SF76">
        <property type="entry name" value="MYCOBACTIN IMPORT ATP-BINDING_PERMEASE PROTEIN IRTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17578" checksum="576D8A3D87F11DF1" modified="2015-05-27" version="1">MFLRTADILERKLRGEDGAYLGTAVEVARYGIPSYYRGISAEPGSIFITANAILFGSYFFGLLGPHLMAIMKARMAAAIIYETIDAVQITSDNGEDMCSCEGRLEFRDVYFKYPTRENPVLRGINWVAEPGETIAFVGKSGCGKSTSTQGCVALPQLANQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKA9</accession>
    <name>A0A0D8XKA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716487">
        <property type="protein sequence ID" value="KJH44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKA9"/>
    <dbReference type="STRING" id="29172.A0A0D8XKA9"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="56"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="239"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="48784" checksum="CA3BD130178DF974" modified="2015-05-27" version="1">MFSRTSIRFYSKANLNLRTILNNELDTIKVAGTYKNERIITGPQGVLVNVMGQTKPVLNFCANNYLGLSSHPEVIKAGQDALVNHGAGLSSVRFICGTQDIHKQLEEKIAKFHGMEDSILYAACFDANGGLFEVLTDPNDVIISDELNHASIIDGIRLCKAKKLRFKHMDLMDLEEKLKDNQECRQRVIVTDGVFSMDGDVAPLKEICDLADKYNAVVFVDECHASGFFGPTGRGTEEAYNAVVFVDECHASGFFGPTGRGTEEALGISGRVDIINSTLGKALGGSMGGYTTGPKPLIDLLRQRSRPYLFSNSLAPSIVGSSIKVFDLLMSDSSFIGSLKANVLRFRNSENFSGKIDYRSNMKKNGFIVLGNDNTHPICPVLLGDARLASEMADALLMKGIYVVGFSYPVVPTGKARIRVQISAAHTTEHIDVAVDAFTEIGKKLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKM8</accession>
    <name>A0A0D8XKM8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heparan sulfate 2-O-sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716614">
        <property type="protein sequence ID" value="KJH42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XKM8"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001418">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="40126" checksum="9B8A549401D08063" modified="2015-05-27" version="1">MRLLNRTHLLFVNLFVITILLLYVTFCLNNERATNVEDSRVTDAVKSRTNSIILYNRIPKTGSTTFTNAVAYDLYKVNSFNVVHINMTKNRQVMSLKDQREFVNNITNWSVRKPAFYHGHVAFIDFQRFGLQNPIYINIVREPLERLLSHYYFLRFGDNFRVGLKRSRAGNNETFDECMIRGGRDCDMRQMWLQIPYFCGQHYFCTVVGSRDALDHAKRNLINKYLIVGISEQIRDFIALLECLIPHFFNGALKHFDSLSESRAHLRNTKRKFPPSNHTLSLIRKSEAYQLEKEFYEFAKEEFKAVFKKATNGSNNALDVLRLPLQFHYEKIKPERLMSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL85</accession>
    <name>A0A0D8XL85_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="4"/>
    <dbReference type="EMBL" id="KN716410">
        <property type="protein sequence ID" value="KJH45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL85"/>
    <dbReference type="STRING" id="29172.A0A0D8XL85"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="50829" checksum="C7908ADA797FD531" modified="2015-05-27" version="1">MGFPSMDTYKIRGEYMQAAADLFENTLTKPPTPNILELWKEHQHIRKELMEISAKQSLLADTDVRLSKTRTQEDLTCFLNWADKIGIKRFGVTVAECREVNGLGLLAEEKISEKDCCLMIPRNAMISTDLARKSSMTKNLFEQDSIVRNMANVGLALFLCAQWIKADSKWSPYLKVLPNVYTTPLFYTEEELQIPALIPMLDMANHETVLGTEDLGETVSYSTEMDCAEVLATRDLQEGEWVGMFYGRRSSAEHLLHNGFVPAGDNPFDSYKLKINLSRSDKMFKEKQKFFMKMGFNENSNVYIHRIGLGPHPFHQSLEHFARIYVADDLEKYLLSTRISKRAKETESEIIGMQDVDVMLGLASLALAIVSSKTASESDTLVKAVNFLKNRFAILERSYGVIAVGKSLNEKNMERLKNVEVAILKNARIFCENWEKALLEATETNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL97</accession>
    <name>A0A0D8XL97_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716415">
        <property type="protein sequence ID" value="KJH45305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL97"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="10020" checksum="E4CF2858C2BAA18B" modified="2015-05-27" version="1">MSLLKGAVRQQHTALDPPTLLSIRPPAPRADLKSINNINMYIGRDVMKLCMVVVQVEVFLETFQLRHSLQRQSQPFFITDQKPFSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLB3</accession>
    <name>A0A0D8XLB3_DICVI</name>
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            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="KN716414">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XLB3"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053921">
        <property type="entry name" value="MKRN2OS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4796_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="300"/>
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            <end position="325"/>
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            <end position="353"/>
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        <location>
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    </feature>
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        <location>
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            <end position="616"/>
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        <location>
            <begin position="229"/>
            <end position="621"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="790" mass="89525" checksum="2C6E3FE4AF12C77C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLE7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716461">
        <property type="protein sequence ID" value="KJH44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XLE7"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
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        <location>
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            <end position="43"/>
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        <location>
            <begin position="50"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="251" mass="28061" checksum="8D51B1C1FA7EE762" modified="2015-05-27" version="1">MFAHDFLKKDERTFRPTSSSKSAWYFCILILTKILRCIGIFFIDILSKGVHVVSLLWLVKMISSMVLLPIQRPFSHGTTLKKRFVSKSVLVFELSPSVLLVAIVSVFKGNSSTSKSRGLFFLIIGYISLLLMDRDQNIAHTHGITHSHHSGLNHLFYHLITTFGMADHQGGVAILFLALLLRIGYDNSFRRLAVEIGGPKRLHSLVSVCSTLLLTPIALLLLAMKTVGSLLCNDLYLVPQRSNSINLIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLK2</accession>
    <name>A0A0D8XLK2_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS-like N-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_08534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716409">
        <property type="protein sequence ID" value="KJH45410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="12284" checksum="4AEEF3418C5A7025" modified="2015-05-27" version="1">MDPSDKSLLRLLSGKAAGTVAIFDKGDYYCCYGNDAVLLATEIFLSDVCLKTLTVGGETLQYITMNNGQYQRTVRELLMFMRYRIELYKLEDDKWEMKAKVFWIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLM5</accession>
    <name>A0A0D8XLM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH43271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLM5"/>
    <dbReference type="OrthoDB" id="5808350at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336025" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="16089" checksum="E6A4B171FAC8C630" modified="2015-05-27" version="1">MLRRTFYQCFLMLVCLEIAHSRKYHPYKGRRYELTLFIRNHNVTDAKFFRLVGVDNTADFNVSVGNTFEQTFEVRRKGYWTLFVEFPGDRYAKSPRKIISRDSYRKWVMEVYYYPGAVGFSEWHKMGRKSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM57</accession>
    <name>A0A0D8XM57_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">BOS complex subunit NCLN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicalin"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="195"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034873"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="406" mass="45151" checksum="9BDFA21DBC799E06" modified="2015-05-27" version="1">MQSIEYTDQYQVHGCQQFGDKVELEFQAFRLQQFEISGSIIGSRNFRVQYEAVSLNSISSVPFVLTRLSKFKPIERYLPRCIVTSWRDLVNHNLNQLLANSVGAILVLIPSDLDALTPNDRMLFADLERKLGLARTELAVYVSYSSPEANAMLTDIQSSSAVRISAIQRIINSVAANITSTGSPSTNMLTYKPNNIIGRLSSGRRSVPTIAFVAHYDSHAPFPGVAVGADSNGSGIVVLLELVAIFRKFYERVPTRPPFNLVWIVFAWTAAGKHNYQGTRQFIEDLQTENSEDNLELAICVEALGGTGSLYMHASKQPVDGSAADRLLRRLRLLSPNRSVELVTKKINVNQPSSWEHEKFNIKRLPAITLSGLSDHDNPIRKSLLDTVGHLSLDVLERNIRQGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XME7</accession>
    <name>A0A0D8XME7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase, patatin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716436">
        <property type="protein sequence ID" value="KJH44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF38">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="30717" checksum="DECBE2DBC56BFE91" modified="2015-05-27" version="1">MLINRPKICHTPIKTIKQFCISLSGCGFLGAYHFGSVNCFLRNGQHVISRLERVSGASAGSLVASLLVLSPEKLGPALNVLFDLGEELTNLRFGALTPGYCLNDKLVKIVQDFLPQDISPAQGRLFISVTKKEERTNRLISHFSNKDDLIKCLMASCFIPLYLGYGSEPPVIDGYACIDGGYTNNLPDFDDIRTITVSPFSGNAEISPADAENFFDWKMTVCNQTMNVNLQNIVRGAQALFPPSRSTLQNYYNMGYKDTFKFLIKHDIVQRSIGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMJ1</accession>
    <name>A0A0D8XMJ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMP-PDE, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716383">
        <property type="protein sequence ID" value="KJH45843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMJ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XMJ1"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716422">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10166" checksum="7D42EABE053C0269" modified="2015-05-27" version="1">MEQSISLVIIPHDERVVLKSTWAAAIPVRSRFAHRSCVPLQRVSFYGRFDSNVIVVISGADLQYVRAVVALSNVRDTNEMFENDFYFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN77</accession>
    <name>A0A0D8XN77_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF hand</fullName>
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    <gene>
        <name evidence="5" type="ORF">DICVIV_08791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716422">
        <property type="protein sequence ID" value="KJH45177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D8XN77"/>
    <dbReference type="STRING" id="29172.A0A0D8XN77"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALmodulin related genes"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calmodulin-related protein 97A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="19306" checksum="6665E35AF749BD1B" modified="2015-05-27" version="1">MTMVNNSYTRTLQCSEDIVKQLTPEEVDEFREAFMMFDKDRNGTISTKELGIAMRSLGQNPTEQEIQEMINEVDMDGNGQIEFAEFCVMMKRMMKETDSEMIREAFRVFDKDGNGVITAHEFRYFMVHMGMQFSEEEVDEMIKEVDADGDGEIDYEEFVKMMSDR</sequence>
</entry>
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    <accession>A0A0D8XPI3</accession>
    <name>A0A0D8XPI3_DICVI</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716486">
        <property type="protein sequence ID" value="KJH44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPI3"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9829" checksum="C33CD2B27F858472" modified="2015-05-27" version="1">MTKRLCEVVAALHRNRTDDRALQDCCRTYMNDDQSGQLFSFLKRAALARLSLKCLLSSYGESEAETGSSGAVTQNQIFDTYRLTKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPM9</accession>
    <name>A0A0D8XPM9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716482">
        <property type="protein sequence ID" value="KJH44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000159">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000929">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000149">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF136">
        <property type="entry name" value="LD28458P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="506" mass="57430" checksum="796D0A1554087B2B" modified="2015-05-27" version="1">MSIDGEFLRNVEVKTDEMFGNSLNALSIIRSGKLIGIIDKEATNDPNALLILNLIKEADDKNQANITLRQIDNRTYLQTSRDIATGERLLLQRYKENVATEDEEDNAEKDVDEILNEEDEVKKVTRLSVEAPVTCQEAREHGELEPGQLVPEGGQAHKCQLCPKSFSSASGLKQHSHIHCSSKPFRCHICNKAYTQFSNLCRHRRIHLDGWQCSLCQQSLPSHSALVKHRPLCEMTSALYKPIIPHLPIPSTSTHITSTYWPHLLHIASQMPSIPIGVYGQMAAYKMFNHNSEVESSPLSSGHTSEHSSFERKCSPCSEAELSPLDLTTKREERKSENESNDSGDEDENDSSFTKLDESNTTCLTPTMNPFSSSAFLSLLQRPFPYSNSSSFAVTSQMSRTTKDRYTCKFCQKANFILLQVFPRSANLTRHLRTHTGEQPYKCQYCERSFSISSNLQRHVRNIHNKERPFRCPRCDRCFGQQTNLDRHLKKHDTSPNLPLTTMLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPQ5</accession>
    <name>A0A0D8XPQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716349">
        <property type="protein sequence ID" value="KJH46525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XPQ5"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="82" mass="10158" checksum="EC9B70AD6806E762" modified="2015-05-27" version="1">MSQRKKVIELYKQLYYMGKEYPKGKDWFHKRLKLAFIKNKDENDPKKIDELITKGEFVVKEIEALYSLRKYRAMKNRYYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQH6</accession>
    <name>A0A0D8XQH6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxykinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716372">
        <property type="protein sequence ID" value="KJH46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQH6"/>
    <dbReference type="STRING" id="29172.A0A0D8XQH6"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF16">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="310" mass="35010" checksum="ABE992489229393D" modified="2015-05-27" version="1">MKFGDDGRLYGINPEAGFFGVAPGTSNKTNPMAVATFQKNSIFTNVGETMNGEYFWEGLEDEVKDKNIEMINWLGEKWRIGDPGPCAHPNSRFAAPARQCPIIHPDWESPKGVPIEAIIFGGRRPAGVPLVFETNSWIHGVFTGACLKSETTAAAEHKGKTVMHDPMAMRPFMGYNFGKYLQHWIDLNKEGRKVPRIYHVNWFRRDANGKFLWPGYGENIRVIDWIIRRLDGEPDIGVETPIGIVPKKGAINASGLPNINWDELMSVPKDYWTNDAKEIRKFLEEQVGPDLPAEIRAEMDRQEERINKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQL4</accession>
    <name>A0A0D8XQL4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydropyrimidine dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KN716370">
        <property type="protein sequence ID" value="KJH46084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQL4"/>
    <dbReference type="STRING" id="29172.A0A0D8XQL4"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="744"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="802" mass="89084" checksum="46412832BC13889B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR49</accession>
    <name>A0A0D8XR49_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716445">
        <property type="protein sequence ID" value="KJH44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR49"/>
    <dbReference type="STRING" id="29172.A0A0D8XR49"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD-40 repeat-containing protein MSI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
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        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
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            <begin position="169"/>
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        </location>
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        </location>
    </feature>
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            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="407" mass="46170" checksum="218A6260D11D6E47" modified="2015-05-27" version="1">MVEGSDGSMEEKVINEEYKIWKKNTPFLYDMVMTHALEWPSLTVQWLPDILKAENGDYTTQRLILGTHTSDEQNHLLISKIQLPTDDAQFDASRYDTEKGEFGGFGAITGKVETEIKINHDGEVNRARYMPQNPVIIATKSPSAEVFVFDYTKHSSVPKDNQCKPQLRLRGHTKEGYGLSWNPNKQGHILSASDDMTVCLWDVQANEVSSGYLDAKNIFKAWHVLHEAVFGSVGDDHKLMIWDIRGNQPAHTVDAHSAEVNCLSFNPYSEFILATGSADKTVALWDLRNMKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQNPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVVCSVSEDNIMQVWQMADNIYNEGEEDTPSDQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRW8</accession>
    <name>A0A0D8XRW8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716350">
        <property type="protein sequence ID" value="KJH46499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRW8"/>
    <dbReference type="STRING" id="29172.A0A0D8XRW8"/>
    <dbReference type="OrthoDB" id="5874838at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="6">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="156" mass="17373" checksum="0F3F213A4F3C3F61" modified="2015-05-27" version="1">MFTNSDKLEDEKLTLPPSLISSPSYLAACVFGSNAVATTYFPLIVSPLLAMTGFYIDPRTVPVYFQFIPPISWFRYAYEAHLVVLFHPLSEIKGCPSNKTFDAIVCSANDGDELLQTQGIDHTSLFSNIIILLIMTIIIRLLALLAFIIRIRKSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTE5</accession>
    <name>A0A0D8XTE5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine cleavage system H protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Choi Y.J."/>
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                <person name="Wilson R.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716317">
        <property type="protein sequence ID" value="KJH47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTS5"/>
    <dbReference type="OrthoDB" id="5867191at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12415" checksum="64837395046F5DA8" modified="2015-05-27" version="1">MENHLDPFAQVLSNKPGPVICALCLTLYHFFQYINNAIFQIPLIKAVPEAIQMTCFLLTDIEHLSPPVCEALLTSGAMPAVLKAIADSMGSFYNMVASQTMGCPPYQTLFDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUQ0</accession>
    <name>A0A0D8XUQ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716369">
        <property type="protein sequence ID" value="KJH46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUQ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XUQ0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="407" mass="46126" checksum="B58FB1DD097D41D1" modified="2015-05-27" version="1">MLVYIIFMTVTYVDLLKLREIAVKMLPSFRSGMALLSPPWIELLVMIQVYILAGIYAVKEIIFEVINQGIKKRLENEVLKSNAINHAGSKCVFITGGDGTIGREVIKRFLGYGYTVHATIGDRRKAFELVTSLGGSKLPLTLYDVDLLTPYEVTRFARGFVNKCGGLSIVIMCAGIMLSGPEFIDNVESHMCVNVVSQALLLHLLNPILLHDARILFLSSATAKVSHYTSPIFRKDPLSYYVGRYQAYCFSKLVLSVYIEQLSKKKSQLLATIHPGVIPGTLYRNTNKYVRYLTYIVLPYFLRKPAFGSLLIAHTAMRDDLISGSYYEDGSVKSLGEGLSEKEIFFLRTNKLSFKLFNYRLNPGPIWKIRTTQEHSYHDYEEDRLLPMLLFQKLDVIVETVLSLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV30</accession>
    <name>A0A0D8XV30_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716364">
        <property type="protein sequence ID" value="KJH46216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV30"/>
    <dbReference type="STRING" id="29172.A0A0D8XV30"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="345" mass="39249" checksum="81CE30C5FB4171D4" modified="2015-05-27" version="1">MPPHKDEIKTERRNSMDVIKNKTRSHCISSTHSNLPVHKVTVHPLVLLSVVDHFNRVSKTQSVKRVVGVLLGSMKKDKTLDIGNSFAVPFDEDEKDKSTWFLDMDYLESMYSMFHKVAAKEKIVGWYHTGPKLHKNDISINEQMKRFVPHPVLVIIEAEPKDIGLPTEAYIEVQEVHDDGTPPIKTFEHVASEIGAEEAEEVGVEHLLRDIKDQTAGTLSQRITDQLMGLRGLHSQLIDIEKYLQDVAANRLPVNHPVIYHIQEVLNLLPDVTHPDYVTAQNVQTNDQLMCVYMGSLVRSVIALHNLIDNKLALQKAENEQEDLSIFRVYSYNVNTLQRLDPIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV49</accession>
    <name>A0A0D8XV49_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV49"/>
    <dbReference type="STRING" id="29172.A0A0D8XV49"/>
    <dbReference type="OrthoDB" id="5970825at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664:SF8">
        <property type="entry name" value="DUF4440 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31664">
        <property type="entry name" value="PROTEIN CBG16427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="11950" checksum="A96F8A74BC0633BE" modified="2015-05-27" version="1">MSALFQEIKSRQQAFMRAFNAGDAKGAAAVYDPDGYFMPNGRHPVKGRIEEYFKEDMADGVQTAQVITEEVNGSGDWAFERGSYHLDGTRGRESGAYLQVWKKASCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVB9</accession>
    <name>A0A0D8XVB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23718" checksum="6D88AA7EC21AC91B" modified="2015-05-27" version="1">MSTELRRRNAYNATNDADKTMSSDVDILPTSSEMSCKRSRSHAERILWGIPVILFYAFWFVFGILVLRKTQNAIAAVRYVKRHGHTVAHEIIENSREFDELIQVLDEEFTRPPAFLLLNQYALNMTYNFLCNTETLEGVHERLIFVTLDTVARDELRRTWPNIRQFHWPTPSLYLGGSLELMRSFCYSNSVLHWAQEDLRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWI4</accession>
    <name>A0A0D8XWI4_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_07255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716340">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26131" checksum="463C40EF76ACF9DB" modified="2015-05-27" version="1">MNEAFPSWYSLCVSNEHYSAKDLNHPFKLPLRSRGFSLYNIDPPLTQLAKHASKILGKALANETDIVWETVISAPELAAVQTASKIAFSATSDKTYVLIDESLCDPEHKKMDFMTPMELMKLDVAATVSLWSKSKESGENSVNRALSDIDRVQRSHKGNLIIVVGPSSFNTIVRQLLCVELKEQKESDIPQLACVILENEPRSWKLYKKQVLPLRNNDNTSTTFDPSFYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX63</accession>
    <name>A0A0D8XX63_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716327">
        <property type="protein sequence ID" value="KJH46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX63"/>
    <dbReference type="STRING" id="29172.A0A0D8XX63"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="214" mass="24598" checksum="BC2598B61C567DD6" modified="2015-05-27" version="1">MGKLRLQFKLFHKPLFGWKGSFVVTQVAAERNVSYDHGMEGSIAEDCFFSMIAMKHGYTFDFIEGEMHEKSPFTMWDFLQQRKRWLQGILLTVHSPRIALTHKALLALSLYAWATMPLTSLQVFLCPLFPLPRCLPFDFALSFVGAVNLYMYIFGVVKSFSHKYRNSALRLMLYLTGALMTIPFNIIIENTAVLVGMCGRKDQFYVVNKDIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXQ7</accession>
    <name>A0A0D8XXQ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="31137" checksum="5804B0EA51FBF0B2" modified="2015-05-27" version="1">MLSFSVVDTDSSSTDGDEGGPDLDLGAFELVDSGMTAETLLSTEEPVIYHKNLPVHSVHHDTVQTEAALMNLMSAPSSMLTGAIPPTMVEDNYCFVVDGEQVRMSDILGDDQWWRHTSRPTKYFYSEDLRQFHRVNCIAVKGKVIAAKLASNSAKARTMAAESSASTPRSSMSGASARPFNRDKVPLTNVYKVIRFYSFWKTCTSFHRIVTMIDRVIETDHTNPDFKKRLFVQYLWRNAKSIEKARVRKEFDPKRQRLLRFVNDSMSQKRSHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXY2</accession>
    <name>A0A0D8XXY2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXY2"/>
    <dbReference type="OrthoDB" id="5784816at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="471"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="555" mass="61981" checksum="600CCDB8C3AAC13B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY41</accession>
    <name>A0A0D8XY41_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_05228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY41"/>
    <dbReference type="STRING" id="29172.A0A0D8XY41"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
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        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="327"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH48669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="784" mass="89683" checksum="6D269E430C5A7B04" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY56</accession>
    <name>A0A0D8XY56_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716257">
        <property type="protein sequence ID" value="KJH48747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY56"/>
    <dbReference type="OrthoDB" id="5912366at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="265" mass="29763" checksum="9C1D42F737DC4B76" modified="2015-05-27" version="1">MPSMISGKTEHAGVFSTKKLDVTAKCISACSLRGMKECHCDAEEDNYCYLCCGNVDHQCLPAHHHNILRPNGERWEREACSRCRVHGVEMEGLPCDDTDSARLCITGRCSNSVCHTRQPGSFCDRKMEKICVDNMCENPCARFAPHLMVCDCPAIDQDTGFASEDRCQLCCYDFNLKPANRRCQNAYRKYKVTDLFQKPIWRVGLECAGGKTCNKYGRSAFDNTFISAIVGFGVPVTEQSSMSGRPMMIDLFKFDISRNRGISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYZ3</accession>
    <name>A0A0D8XYZ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716301">
        <property type="protein sequence ID" value="KJH47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYZ3"/>
    <dbReference type="STRING" id="29172.A0A0D8XYZ3"/>
    <dbReference type="OrthoDB" id="5830877at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="43824" checksum="A87B255526DBD34D" modified="2015-05-27" version="1">MQNNASYEKMSKKELRLGGEAQTSTRDNEFRQYTETFGLQKIQRTSLISQKEQLPCVDNTNSRHRAKTHIKNLCVEARTSSCAFCDYDISLVSPQVRLLGHDECHADHSVERENKSRDHCRSLEKWGLPAVATRDKERLVEEIPVYLEEEATIMGSIGHRTIKAMSNTQSIPENKSYSFQCDVAVRRINTFTDFNEEINFLRAELEKSRVVRSALHNQMFSLRSSLDQVLLEKDALLLKITALSSRLDEKTTQSRQISATNIDSTSKIFELESKISSLLYDRDKILKILLNCDEQLFKEANKLSHVGLSPSDYVAVTIEDESSEFSSVTSAIPSLLTQLLHRIAFIRRRSSRDFPSYFRCGLAAYVVIFHLILSYFLFIAVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ92</accession>
    <name>A0A0D8XZ92_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ92"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ92"/>
    <dbReference type="OrthoDB" id="5783840at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336085" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7742" checksum="FC27259AD428BB50" modified="2015-05-27" version="1">MIVTTIIFALTTTSSGTYTFPYRVQNSSACALIVTGTKVIPMTDCDEGADDKIRSVSLPTGQKCGCKKFPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y026</accession>
    <name>A0A0D8Y026_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y026"/>
    <dbReference type="STRING" id="29172.A0A0D8Y026"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000025">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11289" checksum="C92FA945609253A1" modified="2015-05-27" version="1">MKDEGTRKKKESIVDLARFIDKKIRVKFQGGREAAGILKGYDALLNLVLDNCVEYLRDPENPGTIGDDTRALGLIVARGTAITVVAPADGMEQIDNPFAQQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0A8</accession>
    <name>A0A0D8Y0A8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716234">
        <property type="protein sequence ID" value="KJH49464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0A8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0A8"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="137"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="339" mass="39488" checksum="EF69EBA3378CD12D" modified="2015-05-27" version="1">MFDRQSSFSTYVDWLEELRQQGGAWKFVTKKREFPLNTFYANAKKPRSYEEIFSSVLTSPKVTEAIEEEAVRRGLPVLKIQEDAKSILKIMAHNWGLSSTRTFGYVLVKVLERIFDAIYVNVEQLKRIRELCRSESIVFMPSHRTYLDFLLLSVFCFDYEVPLPAIAAGMDFANSWFMSEILRRCGAFYIKRSIGQDRLYWAILSEYVQTHIIHSERPVEFFIEGTRSRVGKSLYPKYGLLQMVLEPFLKGKVYDIVVIPVTTNYDKLLEELPYSYELLGFPKPKESTTALIKAHQFLNERYGRCFMTFGEPISVRDYFGMSLNRSSIVNQVINTCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0L9</accession>
    <name>A0A0D8Y0L9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0L9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0L9"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="318" mass="38241" checksum="C48E80D0B63802ED" modified="2015-05-27" version="1">MYGAWSRTCLFNQWSISECVKFIRRHVTLRQFSNYQCRIWCCDNNLVSIAFCVSVTLREFRLRFSNRLFVGKNKDYYEILGVSKDASQEEIKAAFYAKSKQLHPDKRDDGDTTANFVELKKAYDVLRRPVDRKAYDMKDNVSHEKCKNAYYQYKKHQERSWEWHRFRKSSTAPFGWSEYNRQSLDQWRFLLIWTIIGVIVVVVINFGYMFLLRVRDRRLSNLVDEYEIAKSFMRQSEFKDKKPNALEIHEIGQILKGNVDEAWRRQQENIEERNPNEIREEYRWFRAVQDVDNRRKMKEKKADELAGNQLKTKGLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0U5</accession>
    <name>A0A0D8Y0U5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716224">
        <property type="protein sequence ID" value="KJH49757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13480" checksum="1248BCC54E8E2683" modified="2015-05-27" version="1">MVLLRRTIKMAACISGCVLAAKLQNEDNIRRVHAFLSERKNFDEHFPRGVWDDNWDFRSPEHLLNSKKYSQASAEEKKKMEEEAKAKATRNIILIRHGQYFMDTEQKNLTPLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1F9</accession>
    <name>A0A0D8Y1F9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DSHCT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716203">
        <property type="protein sequence ID" value="KJH50525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1F9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1F9"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="166"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="840" mass="96522" checksum="B0C62EF7EF25F6A5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1Z5</accession>
    <name>A0A0D8Y1Z5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kringle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_02932</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1Z5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1Z5"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.20.10:FF:000032">
        <property type="entry name" value="Tyrosine-protein kinase receptor cam-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0420">Kringle</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="15">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="480"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="746"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="299" mass="31256" checksum="00D659CDE3477A97" modified="2015-05-27" version="1">MIDTKMCKEKIIIGTASVCSLMAIGTYLTVLSSLLYDINDVYNEVIDTVVLFRVKTDSAWIDMINLQITVSPPSKPRQNPFESIFRQKRQSFNSLPSWCQCEPIKAVCLPGPPGPPGQPGVRGIPGQPGQPGRDNVQTYPSISCSPPERGCIRCPSGPPGKPGIPGRPGRPGPDGRPGIRGDRGINGLPGPLGPPGDKGVPGKPGRPGVPGRPGRDRQRVHGLRGSPGPQGQPGQRGRPGRPGNNGHAGAIGRPGPQGFPGFRGPPGNDGQIGRPGSIGLPGQDASYCPCPPRSVAFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4I1</accession>
    <name>A0A0D8Y4I1_DICVI</name>
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        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_02769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4I1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4I1"/>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH51102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="692" mass="78956" checksum="4B548831C305604F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5C3</accession>
    <name>A0A0D8Y5C3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716224">
        <property type="protein sequence ID" value="KJH49751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5836372at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15425" checksum="FF4FF42064F5CD4F" modified="2015-05-27" version="1">MLSCYHCVSQLRLEGIENDAKLALKELVFQRYHVPPSNEFCEDSNAYDFYTSDIQQCDDTDQCLKLSITQKDLLFVMRGCQSQLLRPGYYLSQETGCTNKGPSQCLCDTDLCNLSNCLNIFLSISIMYVVCELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5S3</accession>
    <name>A0A0D8Y5S3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5S3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5S3"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1109">
        <property type="entry name" value="COLLAGEN ALPHA-4(IV) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="20013" checksum="B375B4E24363643E" modified="2015-05-27" version="1">MGPRGPQGLPGHAGEKGDRGDIGPPGLPGQPGQIQEVASLGGAGPRGPPGLPGPPGEKGDRGGPGLPGQPGSLGLPGPPGPMGLRGSPGVEGRPGKQGPMGTKGEMGPPGPQGMPGHPGAPGERGADGHPGVRGEKGDQGIPGLDAPCPTGPDGLPLPYCSWKPMEVRSDLVEMARTGITGNGYDGLNYEELQPPNRYEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y638</accession>
    <name>A0A0D8Y638_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y638"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13390" checksum="1A9D21C5E3DE868F" modified="2015-05-27" version="1">MSRWSKSIYGEPNTSKNSSYKFLSQLDSCLYEGIPMSDELLDKEARLWAARFPHLRVVGTKLTIYFDRSQHTQKEAIPLRKDINNPMKPSNCNHSIGSVETRASCNRLPCLSNLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6D4</accession>
    <name>A0A0D8Y6D4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6D4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6D4"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000032">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="29979" checksum="DA0B3FBAE3862FC1" modified="2015-05-27" version="1">MEEWNNRELDSFLIEITAKILKFRDDKGEHILPKIRDSAGQKGTGKWTCFAAQEYGIPVTLIGEAVFARCLSALKDERMLASTRLSKPIVDRIQIIPNKNDFIKHVSKALYASKIVSYAQGFMLMAEANRKFDWKLNFGAIALMWRGGCIIRSRFLGDIKKAFDKKCDLANLLLDDFFAKAIEDAQKSWRIAVTSAIHLGIPTPAMSSALSFYDGYSRKVLPANLLQAQRDYFGAHTYELMESPGVWVHTNWTGKGGRVTSNAYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6H4</accession>
    <name>A0A0D8Y6H4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="23">U1 snRNP C</shortName>
            <shortName evidence="23">U1-C</shortName>
            <shortName evidence="23">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">DICVIV_02095</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 23">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6H4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6H4"/>
    <dbReference type="OrthoDB" id="8958249at2759"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
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        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
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        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
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        <property type="entry name" value="NST/OST"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
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        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
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        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19 23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21 23" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 23" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 29" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 23" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="28">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="24">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="809"/>
            <end position="813"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KJH51782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="990" mass="113818" checksum="2B8DFF24DC1F506F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6K8</accession>
    <name>A0A0D8Y6K8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y6K8"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="114"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="576" mass="65676" checksum="7093144B889A0059" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8Y6M6</accession>
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            <fullName evidence="1">Receptor expression-enhancing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_01228</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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        <property type="protein sequence ID" value="KJH52518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="20416" checksum="0573EBA17FA134F7" modified="2015-05-27" version="1">MSVNEPVAAPVAATSDGPMEGGGSPKGGLNPLEGIKKAHEDLVAWCYKSHGSVVDAQLAKLDEAQVKREHVAYGLIGLMSLYLITGGQAFFLSAVIAFTYPAYDSIQVFRAKDSAEALHLLLYWVPFGFFALLDSTFFSDLPAYFFLKTCFLLFLFLPQTQGAKLIYFKVIEPVAKLIDDLQKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6P0</accession>
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            <fullName evidence="4">inositol-phosphate phosphatase</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01367</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="4"/>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6P0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6P0"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Inositol_monophosphatase-like"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="11354" checksum="55A399C0FA82E805" modified="2015-05-27" version="1">MLNSYTSSYKTLMVEQNCHGHRCFGSAAINIVMVAQGSCDAMVEYGLHAWDIAAAAVILSEAGGFLIDPTGKPFNVMSRKILCASTEELAISLSNILTHADFEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6V0</accession>
    <name>A0A0D8Y6V0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01183</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716162">
        <property type="protein sequence ID" value="KJH52598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6V0"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="50" mass="5722" checksum="8E77C7811EB7F284" modified="2015-05-27" version="1">MAERRGGHERATESPSTRSDQAHSWSEITIFLTKLVKENSEYSVRLVCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y761</accession>
    <name>A0A0D8Y761_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            </authorList>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA19"/>
    <dbReference type="STRING" id="29172.A0A0D8YA19"/>
    <dbReference type="OrthoDB" id="10261550at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="230"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH53605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="467" mass="53160" checksum="A9FAD63E4B9CBD80" modified="2015-05-27" version="1">MFNCRDPTCQVSPYLLWPFRVEVQHTTGLLQFFILLILIVISLFDRICPYAHIFLTSTSFLISSFIAIGPHMIIAKSDLYGVKPFTSMVFMPACVSHITSVFLLYRIPYSYRCILFTVDFVIFEILLSIFPVYGATPAQSFLSYQLTAVAINLSFLLVLVLFIDWITNYERKAENVCNVSFKNEERDVEMMQDINKLLIENILPSSVAGKFLAPDRPVDELYARQHKNVCVMFASIPNFEDFWSQWDTSRKLECLRLLNEIICEFDKLLSKPKFSSIEKIKTVASTYMAAAGLNEIEGDIDESDLIEENGNPISNSYVTANNNNSVNNRPTDFNLKMYRNATMMIEFALAMSQILDQLNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIHVTTDMGELLRRGGFRVHSRGKINVKGVKKPMETFFIEIDSKRNSSISNVSNHPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAZ4</accession>
    <name>A0A0D8YAZ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase, aldo/keto reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAZ4"/>
    <dbReference type="STRING" id="29172.A0A0D8YAZ4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="33675" checksum="C909DCFAA265BD2D" modified="2015-05-27" version="1">MSSKPDEILGGWKILSDGNRIPMIGLGISRIVGQMDVDTAVHAALESGYRLFDTAELYNNETELGVSLESNLPKFGLSREDIFITTKVQTKDLEATNWTEESVISSLSKLRTTYLDLVLVHFPRDRYTGADRACEINKRGRKEVWRKLEELKDRGLIKSIGVSNYEVYHLVELLEFANYSPVVNQIEFHPYFTRQTLVHFCVEKGIFVQAFSSLLWGNKDILCEPAVEKLAKKYDTILYAFAVCSGVGIIPKSSNPVRIRENLVKVAAISLSESELESLNGLDRNTAFCPRCEPWKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBH3</accession>
    <name>A0A0D8YBH3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">POT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1 7">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
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    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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    <accession>A0A0D8X5H7</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <sequence length="95" mass="10390" checksum="99590008519DD619" modified="2015-05-27" version="1">MLLSVRLNDKVNCLVTGNTVTSSCDKMDMAACGMQNNMKSIPPQHLTLSGTLKIGNLIMATWSNQMWRTILNRVLRVLSSGPFGMNFQAASVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="14574" checksum="0FBCB325175CAAEB" modified="2015-05-27" version="1">MIGLRLGRFICYTHICRSSYVAVFGDRIWLNKEIGSHTSRQNRCVHNKANATDVQLTFFVQITGVPLLSYVMPQWKMFFVGCVGLVTALISIIHNCLLFYTFNSSKAFIMSSGPLLYSAKDKRVSWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8X8N4_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
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        </recommendedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KJH40908.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="506" mass="57479" checksum="ACF70D549A272B34" modified="2015-05-27" version="1">MLLDVERKFRIPLGQKQFKLVCPVITNDKDMLMIQWTKNGEQVEWDSRYKLAKDDRELRMKTVQLDDSGRYQCQATNGFDPSEDSLSLKDAIVLANSSNKVEFPLNVPASAPAWLLDMNLDWSSPIQINRGGRMELRCPARGNPLPEIRWYKNNIRIVNESPPHIASFIVDPTSLSDSGEYRCVLENRLGSIEAIFKVFVGDFFDGGKRISATETDANQPPEPIIDQPYNTTVKVGHTAQFLCKAKSTQSPLIKWLKEINNPVEIRQRDPNATVVNASGMHLLVLEQTQVTKEHAGKYICVVTSTQGHIVYKAAHLNVVTAYDFISISFGMDNFWYFVIPIAILFVALVLGAISWLRCNQEPSSQKFLSSKPPPPPRIPPPVAPAEYPQSGPEYNQEYKIDNTRSPIILNNSMFRQKHPMGIVTLDRNNIQRAQRGVEESNLYDNSSPQPYWTQPMMHRPISNSVYTANAGNYRTLEVGHPHTRNYPSMCTDEYSEQKQPFITYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8P5</accession>
    <name>A0A0D8X8P5_DICVI</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH40945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="44432" checksum="CF5C6F81FC38983E" modified="2015-05-27" version="1">MRDQFQSFRVGCEIMNTSLSEEDTLFLIQLSFNSSILLTVFSIIALVVNLYLLNCSRYLRRPIGVNLRLCVSLTASDALCAFFYILTYIINVILPNMLSNCWSLLLEVFKLATFFASVFTLLALALNHYIGIVYPFYRHVITPRSVRCAIALAYFIPSTVFLVMFSTVPGGFRAPVPFAFFSKNGCNDGSILRNVVVRWVLVAPFILFVLLISFLYLHILIHMRNIANDPLLQTSKTKRTSSRKLLVTLLFLAGSACLGWLPTTVLFVLICDSCLFQLPLRPTMYLRILSHLLNVLKLIADAFIYASRLIEIRYAMWMFHADLCHRFNGIFGCAPLPRPIPPEFVRYLNETMEHRTVKFSKSYIIQKSLSGTLFICDVFYLITYRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA11</accession>
    <name>A0A0D8XA11_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antitermination protein NusB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716826">
        <property type="protein sequence ID" value="KJH41430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA11"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9704" checksum="912FE10140072497" modified="2015-05-27" version="1">MSRDDNIYSSFTTLLTAYYGHIILLSFYLKVKDGSIGRIAKVEGAQGYGKDMNLFSTYGSFQICSKKKKPIRICIDNALPLEQFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAD1</accession>
    <name>A0A0D8XAD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_12467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="30"/>
            <end position="54"/>
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    </feature>
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            <begin position="56"/>
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    <evidence type="ECO:0000256" key="1">
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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    <sequence length="150" mass="17469" checksum="34B9538F9970D832" modified="2015-05-27" version="1">MNLKTCNFSFELMRKGGQEKKFAANIKIVVQQVAEERRRDRVFNFLHSTVDKDQAVKLTEFYNSWCQLTTVLDEEEYETCRLAGLRLVLSVLNTRSILPLYLSILYDLFVKQVQLCDNEQVLSLLEIHSGSLLVSNLSSRYDCEGFYDRL</sequence>
</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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    <accession>A0A0D8XBG8</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="1"/>
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            <begin position="16"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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            <begin position="24"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KJH39896.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="85" mass="10120" checksum="E1C0621AFBA96501" modified="2015-05-27" version="1">MDPPWTRINQERMKAYTNAAEKALNAIKSHLDAKQQELAEYTNLIHCLEELPKKRTHTIMVRKGYHWYFLIEKFKRLQDDAACKS</sequence>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719131">
        <property type="protein sequence ID" value="KJH39931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5869142at2759"/>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="68" mass="7494" checksum="E7B0513F757F91C1" modified="2015-05-27" version="1" fragment="single">NQKVEGINLITELSSTNPKDVSDHMHEVVVAILTECKNLRSSVCRVALVCAGTLTQNMKGKMDHELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9390" checksum="33FAEA79BF67F50C" modified="2015-05-27" version="1">MHINIFECFNSIFDDNNWISTLFALLVISVHLAEGIYVFLLCDEMRFSFASAAKWFLQTVIVGYPSLTLLKQYVHERRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCR7</accession>
    <name>A0A0D8XCR7_DICVI</name>
    <protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717530">
        <property type="protein sequence ID" value="KJH40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21846" checksum="17A96344EEF1CD48" modified="2015-05-27" version="1">MGKLSGVQLEIDKRLLEHQPEWVNKRWAQYENHSTMEIINELSRIRRISEFNETVISNLRGGYLLNNWLNNALNVANGTMTKPNRMLLYSSHEGTLLSLMYAMGVANDRLVPFASSIIMEIFKDGSDHYVELLYRNDTTTPPYLLEIEGCQPCTVQKLLKRYGSMVVESYGQQQVLCGTPVKKCNGAPVSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCS5</accession>
    <name>A0A0D8XCS5_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
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    </protein>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716794">
        <property type="protein sequence ID" value="KJH41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XCS5"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear transcription factor Y subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
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        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10256" checksum="41B28C0C571EE375" modified="2015-05-27" version="1" fragment="single">MELPMARVKKVMRLDDDVRSQMISSDAPLLLAAASEMFIQELTLRAWQLVEEGRRKTLQKSDIAAAASRFEHFDFLIDIVPREDTKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCZ6</accession>
    <name>A0A0D8XCZ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716807">
        <property type="protein sequence ID" value="KJH41529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCZ6"/>
    <dbReference type="OrthoDB" id="5779998at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17247" checksum="B6335182C8C3F454" modified="2015-05-27" version="1">MSPHSGVSAPPKSSPVCKRITHTFPNRTQCLELCELPCTITNVYMENRNLEMYNCIKLRPPKVSMLGSIKANSFYMTLVVLGVITLTIVFFITLCFCCSHCCRQPVNSRGSSKDALNPADDGEFREYLTEPEVGAMRKERELSRRPRVTPQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDE2</accession>
    <name>A0A0D8XDE2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716642">
        <property type="protein sequence ID" value="KJH42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDE2"/>
    <dbReference type="OrthoDB" id="5812176at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="38925" checksum="E5FFB02BEB598041" modified="2015-05-27" version="1">MGLRRLGKRTPLRTSIVSPLQMSGLLTNGSAMKDRKKAPPFHELELKLLMRLYCDSYEEYHGRGKEDKKNLLRHFAREVSNLGFYQRTEKQIEERLRADCKRRARIHEGQEAVLNSLPSYLQQLYECRKHKANGSNLLGFHDDDYDLLDDDMPSTCKVEVSTPREGTPVGEQPSSEAFMEMEDYEESAASTTKTTRRSPRKTAKASKATESTSPSMDRQELLYEEEIKLSMLRQQLALEELKLIVIKNDLARAQLERETIATERERFELERAKHDQLSEELKLYRIKQDLVRAQLEKETIALERERLKFEREKKEQLLITSFQQNSHVTSQTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDX8</accession>
    <name>A0A0D8XDX8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_11199</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KN716623">
        <property type="protein sequence ID" value="KJH42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDX8"/>
    <dbReference type="STRING" id="29172.A0A0D8XDX8"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07902">
        <property type="entry name" value="Adenylation_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000003">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="219"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="573"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="662" mass="75618" checksum="B9E732B08413CEC5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE53</accession>
    <name>A0A0D8XE53_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717051">
        <property type="protein sequence ID" value="KJH40686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE53"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12146" checksum="E90E20CB2426DE22" modified="2015-05-27" version="1">MEKDAVPSVIGQRRRDHAQIPAFCRPMTGGLPYATRSQSAHHQPIIGPLSNLPQSSLNLKVYCQSIPNTVLGTQTRTFHLHIRSCRCKKHVGWLIQEKKRILPGQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEF7</accession>
    <name>A0A0D8XEF7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rho-GDI gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEF7"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOGDI"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053735"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="199" mass="23051" checksum="B1D25DE5445A0EB1" modified="2015-05-27" version="1">MTDFATEKVNEQPQSQYKPPEKKTVAEILKTDEEDESLTKYKTMLLGSSPTNVIVDETNPKIVIVKAITLLVDGREDVTLNLDDNETIQQHGSLKNSTFILKEGCQYRLRFDFYVQREIVTGLKYIHKVSRHGVQVLKETFMVGSYAPRKELQSYTTPVEEAPSGLLHRGKYKVKSQMTDDDEHDWLSWTWYTEISKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEV0</accession>
    <name>A0A0D8XEV0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716948">
        <property type="protein sequence ID" value="KJH40966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEV0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEV0"/>
    <dbReference type="OrthoDB" id="5875171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF194">
        <property type="entry name" value="CUTICLE COLLAGEN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="29035" checksum="3BC6AAA6E6CFA87A" modified="2015-05-27" version="1">MFEEKLIVGVATACSTLAIVACLVVVPSLYNTINEVHDEVLDGVSVFRVETDSAWTEMMDIQITVTPPSKPRQNPFNSIFRQKRQDFSGLPAWCQCEPVKPTCPPGPPGPPGAPGQPGQPGPPGAPGEDNTSTYAPITCPPQDTSCIKCPAGAAGPPGPDGPAGSPGPDGQPGAPGSPGLDGQAGPPGPPGDAGSPGSPGSDGQPGAPGNDGTRGRGQPGAPGPAGAPGAPGNAGPNGQPGQDGAPGPQGPPGQPGAPGSPGVDGKPGVPGGPGLPGNDAAYCPCPPRSAVFVSRFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF29</accession>
    <name>A0A0D8XF29_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716682">
        <property type="protein sequence ID" value="KJH42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF29"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14319" checksum="AAA914DB796758B0" modified="2015-05-27" version="1">MGYSNKFVLVLEIKAQWQHNKHNSIKATISSKIVAFKKILMRLDKTEKKSSEHIKNNVLMELVIASSLGLFIIWFMHYAKASQLIEKKSSEHIKNNVLMELVIASSLGLFIIWFMHYAKASQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF31</accession>
    <name>A0A0D8XF31_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myosin head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716918">
        <property type="protein sequence ID" value="KJH41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF31"/>
    <dbReference type="STRING" id="29172.A0A0D8XF31"/>
    <dbReference type="OrthoDB" id="5866439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF709">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="608" mass="70316" checksum="ABCC8D8219243EF8" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFQ1</accession>
    <name>A0A0D8XFQ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KN716653">
        <property type="protein sequence ID" value="KJH42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFQ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XFQ1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF69">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="29463" checksum="689C1CBBBB157C34" modified="2015-05-27" version="1">MPGLHKVLEGIIRFRKTVRKDMVKQFEQIRNNPNPTAVFFTCMDSRMLPARFTSSEVGDMFVVRNSGNMIPHANNYGPTGYEVSVTTEPAALELAVKRGHINHVIVCGHSDCKAINTLYNIHKCPKSFDPQSPMDHWLRRHGFTSIKKLEEHLTDESAKALKFSSTGSNFSFEAIIDQENKWGVEDKLSQINTLQQLENVASHGFIVERLEQKTVNLHAMWFDIFTGEMYLFSKPRRMFILIDENSLNQLKTEVEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFV2</accession>
    <name>A0A0D8XFV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Hemopexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10426</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716548">
        <property type="protein sequence ID" value="KJH43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFV2"/>
    <dbReference type="STRING" id="29172.A0A0D8XFV2"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="354"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="433" mass="49115" checksum="A7E970E1ABA94081" modified="2015-05-27" version="1">MRVRSSGRLSVGGVSVSLSVASHLFDTDGPWVTSGSRHLGANVVDVTITKAFTEWMKYADVDFQRLQNPILNIKFGVGSHHCDYPFSSSVLAHAFPPRSPSYDHDESPFSLIGDIHFNDDVHWTPQLLYATALHEIGHSLGLPHVSDVNSVMYPILVEGQSFTPQDILTIQSMYGAPPKKNEANCEKNHPVDEQDSRGGRTTTETNAMPQPCTSKVDAVATYRGEFVVFRNEWFWRVINNGQAIYGPNLISQYFTKLPKKVDAAVEIHGQIWIFSGRNFWIFSESNHLKGPHPLVNLGLPETLSRIRLAYQWHYFNPPATYLWSEHEYWKLDIKMRKVEASYARSIVLNWKHVPQHATAAFTYEKELYFIEDDMVFKMNTTDYRLPVSKGFPVSISEFWPFCKERQTISAISVFCLCFTSYAKSANSCLSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG36</accession>
    <name>A0A0D8XG36_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DICVIV_12692</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716849">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_24"/>
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        <property type="entry name" value="UGGT_TRXL_1"/>
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        <property type="entry name" value="UGGT_TRXL_2"/>
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    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
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        <property type="entry name" value="UGGT_TRXL_4"/>
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        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="19">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="20">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="21">
        <location>
            <begin position="332"/>
            <end position="576"/>
        </location>
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    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="22">
        <location>
            <begin position="608"/>
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    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="23">
        <location>
            <begin position="1121"/>
            <end position="1404"/>
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    </feature>
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        <source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJH41331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1585" mass="181801" checksum="72FAF3E1911F2D7B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG49</accession>
    <name>A0A0D8XG49_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
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    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
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        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08059">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="4">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="311"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="504" mass="57171" checksum="8EE306D455918576" modified="2015-05-27" version="1">MAYHQGRVSMCCVCDVIWYITSFAIEADYNTLYRKTYAQLYSHNEQKVGFSIHFCLKKIRRVKMFLRDATKFFLFSMLCSIRTLGNLQKDDRDSGEESDGGGERQGFFVGGSEHSGQQVLGPQRPKRNNDIVEKIFTAARQHGAEMLNSQDLVSRSRHEQHGTSSGGVRLGANFSGPLEPGEADHEDNDTGEPEEVVVELIVWENGFSIDDGPLRSFEEPESRQFLESIMEGRVPAELLVAHPRRRIDLRMQRRSGPYEAPKLKPFQGAGARLGAIVPQVVTSTSVPSSSNSTQDPVENMKKAQSEVSLDSNSPVTQVQIRLPNGQRVCGRFNHSHTVDAIRTFIVSAFPDMGASPFQLMTTFPNKVIDDETVNLKDAGIINAVMSIKEWLGIDKIQKLASMVKQMGGWRVALKKRYLMDATRVGTLVGTDKFGNRYYEDNSFFMPRNRWVEYPDKVWLDYDASQVPPEWHRWLHHICDEPPTVKPLKTEKWVLQHEENLTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGD3</accession>
    <name>A0A0D8XGD3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypoxia induced protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0389 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716532">
        <property type="protein sequence ID" value="KJH43710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGD3"/>
    <dbReference type="STRING" id="29172.A0A0D8XGD3"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF17">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335757" evidence="8">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="9">
        <location>
            <begin position="323"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="48378" checksum="644399429E1BFC25" modified="2015-05-27" version="1">MLISEIFLFLRFKYVVCCDLMIAVVISHCEFDLRKCSLEFVVSRQYAMPCYFRCFFRAKTFGSSFSPTKVGNFSMLACAERSSMLCLESFFPSISLSRRMISDRISEAYKSPLKKSSQTDEKDGAPSYVIKASYGDHILKQRIFGADAGSGIQPTKWQKRFLVITRVYKNQAEIPPYIASGTMARMHNRMRVLFIFVAVIIFYIVFFIAEITNSNRIDRDRDAGIVVKKMPFLHFGESQSVGDETNETNSLCTLSDQLGQFNTNFAVIFLHNLPPTNMEVFRKVFMNSTTVQKSFDDSTVTENSPREQISGIEKEGRYSGIPAIPSDIAFSSGKDIAGKKKSGVASQMARNPTVILGMGLTTLALLGMLKSSFIGDKLGTQKYMRYRIIAQFFTVTALVAGVTIFGSTYKDDDVVKSKASVQKPEIQLNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGD8</accession>
    <name>A0A0D8XGD8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldehyde dehydrogenase family 4 member A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_11200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="KN716623">
        <property type="protein sequence ID" value="KJH42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGD8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGD8"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000326">
        <property type="entry name" value="ER membrane protein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="60"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="EMC2 TPR-like" evidence="14">
        <location>
            <begin position="601"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="969" mass="108572" checksum="B325A48AC83C3B24" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGH3</accession>
    <name>A0A0D8XGH3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Clathrin adaptor complex small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716816">
        <property type="protein sequence ID" value="KJH41481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XGH3"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000012">
        <property type="entry name" value="AP-3 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="176"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="480" mass="55386" checksum="60C440B7E56AC414" modified="2015-05-27" version="1">MLNSLFIVNTSGDVVFEKHWKAVIHRSICDYFFDAQKKATSHEDVLPVLSTPHHYIINVYHNQLYFLAVTTTEIPPLMVIEFLHRVVHTFSQYFDECSDTTVKENCVMVFELLDEMLDNGYPLVTELNILQDLIKPPNFLRNIANQVTGRTNHSETLPTGQLSNIPWRRQGVKYTNNEAYFDVIEEIDAIIDRQGSTVFAEIQGYIDVCCKLSGMPDLTMTLVNPRLLDDVSFHPCVRFKRWENERVLSFVPPDGNFRLLSYHIGTQNMVAIPIYVRHSIVLKGGVSSRLEITVGPKQSMGKILEDVVVEMLMPKAVLNCNLIPSQGKYTFDPSTHLLQWTIGKIELGKPPNIKGTASFNFLFTYIYIEFFFRTVMFEVSVSGMATIETPPISLRFRINQLAVSGLKVNRLDMYGEKYKPFKGMLCSQYTRRFIRTTFPPFSQKKFKEVLPPEEVVVYRPENPLVFFLFFTYLLFILLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHB9</accession>
    <name>A0A0D8XHB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716590">
        <property type="protein sequence ID" value="KJH43127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHB9"/>
    <dbReference type="OrthoDB" id="10500382at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="12622" checksum="DBCE77FFE87A76D7" modified="2015-05-27" version="1" fragment="single">TKKQPTSEQAELPTVCNSTLSSPSHSSSVGNPHDIKHCTLFSPSNSSRKKFTLFQQGLQKVGDKMRKGMAASSFRQISYSSTISDILSDWNYSRKDNETEQLAMSNSQSDHHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHY6</accession>
    <name>A0A0D8XHY6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KN716487">
        <property type="protein sequence ID" value="KJH44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHY6"/>
    <dbReference type="STRING" id="29172.A0A0D8XHY6"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF23">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="346" mass="40075" checksum="004B86810D3DC055" modified="2015-05-27" version="1">MNELRQQYFDVGIAEPFDICGFGMMSTKGDVMGILERLKNVIEILLSAIFFEQLFSMEILAFRTKYGNDFKSYEELLSQVSYVFTNSNPYLDYPRPSIHKSVDIGGITVSIVTKDKLPKVTHMTTQRPRKSLCEVFKAMPNTTFIWKYENEDTNNMFSYLSNVHLRDWLPQRALLADPRISSFVTHGGLGSTTEIAYMGIPTVILFMHHSICLHRLNDMNLLHLIGMIRNLTQYPIKFEIIKELEIIKRVYGLRVIMIYSIRFFAHTMHLSRFQIPLFGDQKRNANMLAKHGGAIVLEKHDLANPDKLIEAIQTILTENRLVYIVTSLIQQFRIIIFTMTLQHLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIG3</accession>
    <name>A0A0D8XIG3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716474">
        <property type="protein sequence ID" value="KJH44435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIG3"/>
    <dbReference type="STRING" id="29172.A0A0D8XIG3"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16501" checksum="6DAA34A2C645B69C" modified="2015-05-27" version="1">MASKEKKALITMEPNDKIRFVGDFNCEIKTYLKITNKSDMKQAFKIPENDKHHFGVYHIPAPEGCTCEGAWSEHYGPPQGEFRLKDFTYCLPAEFCKIICYLVIACGFDRSTLMWNNNRAFMATVHDVEILLTPRLKAEFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ58</accession>
    <name>A0A0D8XJ58_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="KN716527">
        <property type="protein sequence ID" value="KJH43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ58"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ58"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="183"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="758" mass="84751" checksum="14DBE89C9EFA133E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJX2</accession>
    <name>A0A0D8XJX2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="366" mass="42325" checksum="C8796A30D315B17C" modified="2015-05-27" version="1">MHTVSNNCWLLCFFINVVISFDEVVKEDEETILQRIDEQLKNNKNHNMHNEDNDEMDEFNDERRQRSNMYTFLYKRLKENSDEKSKSRQLNPDVYLIPGPQEPLPGRSHLGNYWPVFPFHNQFSGGLDLDPALSRHIGGDINIAVPSWGMMDIYGRFFNRIHDTTTKFGHINYPVNMLDLDETDFVKLISDPSLQYNRNTHPLLPLGKLAKTYVPLSCKPPMCNPYHASFGFGLEHDFGGSDGVEGDIDVPIPISKSVAYRFPFSGNVYAFRDNITVTYGQNLAAIDPFSSLFDYQKRRDPSLAIPRQKRNVPFSKKATHRLLENNFGHDDINRRPQKYAPYMIPVIRKYSWISNLDEDIIAILIT</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="323" mass="36101" checksum="615A6EB49FF95DD7" modified="2015-05-27" version="1">MTEEEDDNDDELSDDESDSETNKNDVVFHSVSLSHYGGINRIKVERLGDSTVCAVWSDTGKVELWNLTTAFNECCNTSSKTNNDKHIHEKPMFSHSTRKEGYALSWSKLKQGNFASGDQCRDIHIYRMHEGGTWAVDQRALCGHSGSVEDVHWSPTEEGLLASCSCDSTIKLWDTRCKPTDACVCSVNKAHGTDVNVISWNAKDPYLLSGGDDGELKIWSLKTIQYGQHAARFKYHRAAITSVEWLPQESTTFMASGEDDQVTIWDIATETDSCESVEGVPTQLMFLHLGQKEVKEVHWHPQIAGLALTTSIDGFNMFKTINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKC4</accession>
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            <fullName evidence="6">LUC7 protein</fullName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="325" mass="39083" checksum="EDB46E0CB55FF9FE" modified="2015-05-27" version="1">MSARNAMAAMLDELMGPKRNVELGKDTTVTFDDPDICKYYIVGFCPHDMFVNTKADLGACPRVHDDNLRLEYPKSDKFEKLGFEREFLKFLSRLDEDNQRRIRKNLEKLKTNEENGQKKEDMRKLREEQEMARLDGEIKKCMADAEKAGEEGLVAKCQELVEKAEQLEKQKASIVERLNSNIPATAPIDESAIKIMEVCEVCGSMLIKNDAQCRVEEHLSGKMHMGFSKIKVTIEELRERIRKRDEENEKERQKAREEREKRDRERRRSRERDRSRDRDRRTYRRSRSRSRDRERRRSRSRERYRRDDRDKRNRDRDDRDRRHRR</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716607">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF236">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="28780" checksum="F77463E23DD718B3" modified="2015-05-27" version="1">MFVVGFASTVALVTTIACLISIVIIVNDINDLRDDVLHTVGDFKNVADNTWNQIIALHVHPTTDHDAPPIFASLFKRHKRNGFPPECNCGPLPENCPAGPPGPPGSPGRPGFDGEDGSDGRPGVKGIALAVTQHIPGGCITCPAGPPGPPGARGNVGAPGRDGERGCEGPQGEPGIPGPKGPTGEPGLAGIPGIAGRDGYPGAPGCRGLPGRPAPRGDIGPKGYPGSDGKPGERGPPGERGPAGPSGRPGNRGNQGPPGADGIPGIPGRPGSDQGYCPCPPHGRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLS5</accession>
    <name>A0A0D8XLS5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">K+ channel tetramerization domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716570">
        <property type="protein sequence ID" value="KJH43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLS5"/>
    <dbReference type="STRING" id="29172.A0A0D8XLS5"/>
    <dbReference type="OrthoDB" id="296522at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000070">
        <property type="entry name" value="K+ channel tetramerization domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000005">
        <property type="entry name" value="potassium voltage-gated channel subfamily G member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003971">
        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF133">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="211"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="495" mass="56318" checksum="9702F22ECD996434" modified="2015-05-27" version="1">MISGATQQHKKRLIPLRKTEAMSQAERKNFAILDDVWRNGESDCFQIIPPGGIGPDGEPMFLRLNIGGQRYMLLVDALLRADPSSFLAKFVQLTHSVRLKVADAYLPSEDSYFFQRSPVTFEAIFQYYATGVIHRPAEICPAAFLNELDFWRISHKHVGSCCADIVPIKKDEEKEEEKVDDTTFNNLMFGKVRRRMWTFLERPGSSMQAKAFELSSTLFVAISVMGLSFGTIPDFQVITHYLPPRNETIVLSNGTVTIVEKVEEMRVEHPAFVFTERICIAFFTVEYCLRLFAAPRKLRFALKPLNLVDLLAIVPFYLELLLTLCGVDDKKLRDLRWAFLVVRILRVLRVIRIIKLGRFSSGLQTFGMTLQRSQKQLQMMTIVLLTGVVFFSTMIYFLEKDEDGTPFTSIPAAYWWCIVTMTTVGYGDAVPATTMGKIIASAAIMCGVLVLALPITIIVDNFIKVAQDEQQAEQMKIDQSRQELMLHSMYHVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM72</accession>
    <name>A0A0D8XM72_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CEP76/DRC7 peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM72"/>
    <dbReference type="STRING" id="29172.A0A0D8XM72"/>
    <dbReference type="OrthoDB" id="2162143at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="49882" checksum="42F68B7B2284AD9F" modified="2015-05-27" version="1">MLILVNVLDKDDREVNTIHEQLVRRLIGWIDIPFSTIFSFGKIDGWLRLRRPNFHTEYSIPDSPSYIKVLIAFKPSIIPPRIIPPRLLDSLENEKIISQCQSWLNTCNSLYNSRRYIALVTDINGKAVLACRYLCPVSPPPVIPQSDATNPMKPIKIAARLVSMIPFITDPVLFPGSTDLWTSNEKFLSLGCGDEEEHAVLLCCWLLSLEITSYLVLGSSLPEGLKAAYVLVMLPDGIYLINPCDGSVYSSTDPMCPFISIGTIITSTNIYGNIQSFSHPSQMRFDLNKTNDWRPVFDKQLVELRSLQSASLIYTQISDDVIVELRSAIEREIKLCFDEARQYGIPQWNLMASRLLRELMQDEQHTVDNRFGRLRESYTVTATAITIPYRSIQDCVNAVLRCALHTTTSVSTQFALAVHLQPVFHNVIICNIAIAMLTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM79</accession>
    <name>A0A0D8XM79_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716554">
        <property type="protein sequence ID" value="KJH43491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM79"/>
    <dbReference type="STRING" id="29172.A0A0D8XM79"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="223" mass="25583" checksum="2DB25F45E0B0517C" modified="2015-05-27" version="1">MLKQDRRRKKTLIDLKAEMCDVERITEKIVRDTVCSNLLKRIVDESLVPVDSWEEGKTEYLNASFIYDDDPRQPMYIAAQTPRAADVTAFWQAIWQHGVCLIVNLSTIDEVKQEKSYWPESGSEIHGPFEIHLVSEHIWSDDYLVRSFYLKNLRNGAGRTGVFCAVDLLCARLLKGVRQLDVVASVEHLRDQRDGLVRTADQFKLIYGCVAQEVNSLLKSLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMH5</accession>
    <name>A0A0D8XMH5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KATNIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716438">
        <property type="protein sequence ID" value="KJH44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMH5"/>
    <dbReference type="STRING" id="29172.A0A0D8XMH5"/>
    <dbReference type="OrthoDB" id="304622at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="1">
        <location>
            <begin position="79"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="1">
        <location>
            <begin position="280"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="1">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="469" mass="52803" checksum="CA073B3F49D4D371" modified="2015-05-27" version="1">MNGLVDEDDLQFEIPELPCGRTLCLELLSNWGDSKYIGLNAVEIFSDTGKRSEITKISTDASRSIGDVESIFVESFSCTDRSEMWRAEFEPNRCVRIEIEFVGRTRIAMIRFWNYSESRVHAQMGVRRLRAILDGFSIFDGEIDCAFTDHESEPMGETILFTTDESILESIAENDGCFEKSQEKNDYSRDITGDELALELTPDRPITREVNQLNSIKEKPTNITAPKVDDHKSIGKVKVLQLELCENWGAPGLIGLTGLELLDHNHDIIDPSTVTISSSNETQSDPKKLLNGNNLSRLADDMWLTSFDPKNPLTIIILFDKPTVVKAISFWNYNSSPEMAYAGVRLLNICFNGKPVANSVLLRKAPGFVLFDFVQDVRITCPPTVRTLIRPATKSIYGFIFQLRLLSTWGDEFYIGLNGIELYDRWDRKINVGPHNLAAFPESINILPSVEGDPRACLNLINGCNDTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMU0</accession>
    <name>A0A0D8XMU0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716377">
        <property type="protein sequence ID" value="KJH45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XMU0"/>
    <dbReference type="OrthoDB" id="409824at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="32315" checksum="8540C9D58429FD79" modified="2015-05-27" version="1" fragment="single">RRLEARHSDAEYLSVFIHCNPDSESTLWSSEAQVEFRLHSRRPGVPLLSRQFTKKLNFYTKTDGFPSFIKWRDIMDVNQGYIEDNKVMIEALVTVRKVVGVRNTDCIDFYSQEPHTSDGVLVIGEVRLHVNKAYLALHSPVFYAMFFGEFSEHDKCEIPIEGVILDEFIELLNVVYPSRKPITTENVEFLLELSDKFDIRYVIDECERFLISTQSIDIGKKLVLAGKYYLEKLENDCVRKFSTTENFKKLRRSEDYEDLSDATKVTLLEKLFKILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMU2</accession>
    <name>A0A0D8XMU2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716429">
        <property type="protein sequence ID" value="KJH45072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMU2"/>
    <dbReference type="STRING" id="29172.A0A0D8XMU2"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33771" checksum="7E7FF783F97C1AE5" modified="2015-05-27" version="1">MEADDILFLKRLTTEQLIEKLIYYKNLHEKDAKDFEEYRTNSQEMELIMEREIEDAQREAKSAAAKLRQLQIDAGRAQSKSEEEKRDFLRIEEALRREVSLLRAEQEGSRSRIRELEQRNDDLERHERYNQQEVADLERKVNEMTERLTLLENELAEKQTTTEEMYRLREEIRANDRPRLVVGPLRAERTDDTPEEPTPGTMKEHKSIQKVHAIGSTEVNQKNNISYMNALNDEPNNSGNSKILMNPLVSAADGKSFASCVNKIVKDLMVKVDRLESILTGLRVHSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMX1</accession>
    <name>A0A0D8XMX1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coronin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716381">
        <property type="protein sequence ID" value="KJH45880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMX1"/>
    <dbReference type="STRING" id="29172.A0A0D8XMX1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="439"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="897" mass="99037" checksum="44EC594A21270387" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMZ7</accession>
    <name>A0A0D8XMZ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone deacetylase interacting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716379">
        <property type="protein sequence ID" value="KJH45910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMZ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XMZ7"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
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    </dbReference>
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        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="247" mass="28381" checksum="66EBF8934EE8FF32" modified="2015-05-27" version="1">MEIAILKLVSNERNQSHFTAIIDRGKKETYFFLVMELVGKSLADLKSSRPDKVFSISTGLGASIQCLEACQDLHKYGFIHRDLKPANYACGLGDKKRVVYILDFGIARRILNDKNELKTPRVSVRFKGTIPFASLACHKGIEMGPKDDCESWYYLMLDLTVPGGLIWKRMADKNEVMKVKEECRNVKKDSMFGPLKCRDELFRVLEYIDKLQYHDHVDYSYIYKMLEEAAILCGGNVNNPYDWENDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPU0</accession>
    <name>A0A0D8XPU0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716341">
        <property type="protein sequence ID" value="KJH46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XPU0"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12047" checksum="8FABE7F2A5BD9AEF" modified="2015-05-27" version="1">MGGTLMEYLNRVGINSKPNGFPLIFVFILRKSTEAINKDTVNAPPLDEYWKESTMVAVDGPKGVAFYPNCSGFIRSEAEYMWSLNPEGIPKIGQIWPTLLAHESPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPX2</accession>
    <name>A0A0D8XPX2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716383">
        <property type="protein sequence ID" value="KJH45839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPX2"/>
    <dbReference type="STRING" id="29172.A0A0D8XPX2"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002048">
        <property type="entry name" value="Septin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="56"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="421" mass="48852" checksum="1EA1240C0B817F75" modified="2015-05-27" version="1">MFPIEAEPHPPRAPPQPPPHGNKDRKEPRSGRTLELNGHVGLDALPHQLVKKSVEVGFQFNLMCVGETGMGKTTLIESLFNMKLDFEPCSHELKTVELRTRSYDVSEGGIRVKLRLVETAGFGDQLDKDQSARVIVDYLEAQFERYLQEELKVRRTLNYFDDSRIHACLYFISPTGHGLKALDLVTLRELAKRVNVIPVIAKSDTTCKDELMRFKSKIISELRSHKIEIYQFPTDDETVARANAEMNNAVPFAVVGSCDFVKKENGMRVRARRYPWGIVEVENEQHCDFVKLREALIRTNVDALRERTHNILYENYRRDRLRGMHMGDGDTGPKMVEKFTIKHKEYNDEFACREVKIREDFQKSLDAKEAELRQREEALNVRSREVEDRAAQELRRIDLEIRTLYDERTRLLAKAAKKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQB7</accession>
    <name>A0A0D8XQB7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716333">
        <property type="protein sequence ID" value="KJH46838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQB7"/>
    <dbReference type="STRING" id="29172.A0A0D8XQB7"/>
    <dbReference type="OrthoDB" id="5917548at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006954">
        <property type="entry name" value="Mlt-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21523:SF46">
        <property type="entry name" value="MLT-TEN (MLT-10) RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04870">
        <property type="entry name" value="Moulting_cycle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="520" mass="58417" checksum="3E00B9B34943227F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQD5</accession>
    <name>A0A0D8XQD5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Wilson R.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716315">
        <property type="protein sequence ID" value="KJH47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRF9"/>
    <dbReference type="STRING" id="29172.A0A0D8XRF9"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041194">
        <property type="entry name" value="GLD-3-like_KH5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22801">
        <property type="entry name" value="KH_GLD-3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17905">
        <property type="entry name" value="KH_GLD-3_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Defective in germ line development protein 3-like KH5" evidence="2">
        <location>
            <begin position="375"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="683" mass="77255" checksum="826B73AB91C40597" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRR1</accession>
    <name>A0A0D8XRR1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XRR1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="30948" checksum="DB2E81FF2A007063" modified="2015-05-27" version="1">MKYAQLVIGPAGSGKSTYCSVIYNHCLTIGRHVHVVNLDPAAESFKYPAAVDVRDLISVDDITEDEELALGPNGALVFCMEYLVQNLEWLHDQLCEGEDDYFLFDCPGQIELYSHLPIMRQLVDAFRAWDFNVCSVFLIDTHFVLEAEKFIAGALTALSAMVAIETPCVNVLTKIDLLSDRNKALIDDFLDTDTRSIVEYDAVHIWNERHRQLTNAIAQVIEDYSIVKFISLNSDDEESIAQLLLVIDTTIQYGEDLEVKDRYPEDKDPEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS03</accession>
    <name>A0A0D8XS03_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_06488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716308">
        <property type="protein sequence ID" value="KJH47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS03"/>
    <dbReference type="STRING" id="29172.A0A0D8XS03"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="392" mass="43178" checksum="D93714F0F41A05B3" modified="2015-05-27" version="1">MSSIHYKFRATLEYKTLQFDGLHITGADLKKEICLKEGIKAEAFDLLLQNAHTKRSYTAEELIPRNSSIIVQRVPREDAEKLPKIQGVNTGIVVRNTTVETGMVAPAHMNPEDFEKLSEEDQIAHIKDVSTAKYHSSNFQKKTTSIMSGPPPPTYTCNRCYQPGHWYKNCPMVITIRAPMRLFVALATKRTTGIPSQELMETTPEDPLAMLHPSGKLVVPIMHWKARQHTKKATEEGPTIERVPPPELICPICSHLLKDAVLTTCCGHSFCADCISNKLMESPDRQCPGKNCEQKQLSVDSLVPNKTVRQAALAWSVGASGSGNQEYDQTRFRIGLQPTVSSASTPPLTLSATVSHSLTPTTSVLTHQTDSLHSQNSSTALTMAPPVSHSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT24</accession>
    <name>A0A0D8XT24_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine diphosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716326">
        <property type="protein sequence ID" value="KJH46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT24"/>
    <dbReference type="STRING" id="29172.A0A0D8XT24"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="5">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="240" mass="26750" checksum="D4618D8AA759B877" modified="2015-05-27" version="1">MPATNICVWLNGARESERPIWSKLWNNAEKRYCTDGGANQVVNRDQKLRPPDVVVGDMDSILPMVKDGLKLTTLLIHTPDQNKTDLTKCLEGARVVLLGGTSGRFDHVLAAINSMLYSTTLMTQEVFCLEGENLTFVLNEGEHYIKVDQKLITGTCGVIPFCQKTTVVTMTGFRWNLEGIEMAFGGLISTSNVIEENVLQIKTTAPLLFTMELQPSASEKIAEIINLWRRVSRFTERGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTK4</accession>
    <name>A0A0D8XTK4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_06750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XTK4"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="873"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1277"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1277"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1318"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Hallsworth Pepin K."/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUX0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11832" checksum="B7204C23D3EE5507" modified="2015-05-27" version="1">MKNLLLRYEIIIGKTGYGTELDLRRIVNENESTTLVKEEPNRFHVTPQRLNHLRRVSHSQENFDKLKIYKVWDVVYSIYHLANTSFTTPEGFLRYSDCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUZ6</accession>
    <name>A0A0D8XUZ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716365">
        <property type="protein sequence ID" value="KJH46181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUZ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XUZ6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF17">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="74"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="39392" checksum="D8C0AFF05257AC91" modified="2015-05-27" version="1">MATTVQRPKAFESNYRRRSKVGCWERRRRARAKAKYYKELIELQEIFEYDNRLIEGNEIILELEKGPDRILTRITLLLNIVLLFVNLYAAAASGSLSIVSTFVDSFMDITTSLVLNVCLWLIHNTNSHKYPRGRERLELLGVILCSMIMGIANMFLIMQSISAIITGKIETNVNLLVLAAMISGSLIKSILMIVCYKRGSTTSKVIAMDMRNDVATSLVAIFAATVGDIIWPYADPVGAIIVCGLIAVSWFHHALQHVPILVGVRAERDQLARILRLTVEHDERIRYIHHAMVYHTGMQATVELHIVMDENLPLKVTHDIAHTLEEKLVKLDFVERAFVHCDYDCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVR2</accession>
    <name>A0A0D8XVR2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVR2"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="340" mass="38059" checksum="B24A1EE85A004213" modified="2015-05-27" version="1">MLVLLRCLFQFNFNKRCQMAMSTAISEVFVEEEGSKRILTLNRPKALNALNLSMVREIYPNLKKWEEAEDIKMIILKGAGEKAFCAGGDVLAVIKSAKEAASAGTSTIHKDFFREEYKLNHLIGSLSKTFVAFIDGIVMGGGCGLSINGQFRVATERTLLAMPETALGLFPDVGGSYFLPRLENNLGLFLALTGSRLYGADALHAGLATHYVASSELEKLQTKLLAMKKVTHEAVDEVIREHKPSQIPGFSLQEHLPTIKRTFQAKSVEEIMENLRSEDSKWARDQLETLSKMSPTSLKITFKQLENGAKMNFDKVFTMEYRLTQRCLENHDFYEGCRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW44</accession>
    <name>A0A0D8XW44_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_05161</name>
    </gene>
    <organism evidence="8 9">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Hallsworth Pepin K."/>
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        <source>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWN3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWN3"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336026" description="Integrin alpha-2 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13312" checksum="3A9B6837EC73C7D1" modified="2015-05-27" version="1">MKAWLVLACLIAVNNTFNIDTKNAVLHTMSSGYFGYSLDFYNEEKGMPVLVVGAPESESTNPGLRGIRRPGAVFICSVNKATCREVHIDKKRTCFMSLHRSNSNRRQLPFAFIYRPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWT7</accession>
    <name>A0A0D8XWT7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWT7"/>
    <dbReference type="OrthoDB" id="10070972at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF0">
        <property type="entry name" value="DISCO-RELATED, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="247" mass="27314" checksum="7154147724960940" modified="2015-05-27" version="1">MHMCTIPGCGKEFSSRRSRNRHSANTNPKLHMPEAVQSFREQVGINTAAFTMAAATACLPSSASVSLPPVLHLPNISETISSSSIGSEVEKSEATSSILGKRKAEDSAQNQTAIPLDLSWRNTFFNTTTIKLPFTFPSSDLQLFVLQQIVQAQHPNYSRKSFHTEFTNKNCSCRSTFCTELAEQSRLNTSISLAPSLFSSFVTGISSCVYVITQCFKEFYSELPHVVLMLSICKVNVTVALFFLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXF9</accession>
    <name>A0A0D8XXF9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716267">
        <property type="protein sequence ID" value="KJH48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXF9"/>
    <dbReference type="OrthoDB" id="5807375at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35060" checksum="046EEDEDF8572F6A" modified="2015-05-27" version="1">MNSNYRYSLVFPITTKKALVGSGYLVLGLFGVCLNLSTLSILPECEQSLGRPLLIFFSIQLFIAIGTLIFVAIPVPCMIATNRPYIMNPLLSGAPGLLICFTLVASFVLQFCICMYRSVRIVFNRTTQCLFPDVVMQIIIGVAFLLSVHISVTITQSTNVRRFSLIHLNWQQSDHEYISLLTVVVYFSLASLMFYALSIFHLLYEHIYDKNQYKDSTIAMKTQLLCLICDIIFATLLMLPRIDEPSKYPNLTILHSILNIIGAALWPTAYIIMYSKKVRTELCFRTFLMCSACSRNKNTPSQNNRIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXG2</accession>
    <name>A0A0D8XXG2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716322">
        <property type="protein sequence ID" value="KJH47046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXG2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXG2"/>
    <dbReference type="OrthoDB" id="5859745at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="405" mass="47420" checksum="CDC91B7CEB236E32" modified="2015-05-27" version="1" fragment="single">QVRRRIRELFDPVILSGHAEITYSKNVPWTTKETEKLLEHYKVLGLSCSAIQEIGKLMNRPSHSCENHLKSVLARTGPIPNFLWKKLWVLVTKQTSLPSGKNLEFVIQKDILRDRIKEYDKYDRNIPWDFVAPKMVYSIEMVKDAWFVVFFSFKSSSIPCLMCRKHQVLRNLESVFKQLLSEKGFSLEVFATVPSISCEDFSRFLQILNEFTPDDTAYNLWNRKLYNRSLLTKRLEEEGIVGFYCGNRDELTYLYCKTQAILWRVNNLLFRRMKLPYSLKERTQILSIGYSNQCEYIRNDLTSSDSAEKEIPYRYHPKYYALKHGFPALHRAPFVEAFIVFSLSHFSDWIPPTAFKKYVVSEEVLSLFPSEKNNSELIRQSDLNAALSFIDCDVYSEMSTSDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXH6</accession>
    <name>A0A0D8XXH6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05328</name>
    </gene>
    <organism evidence="11 12">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <end position="518"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="4">HannoverDv2000</strain>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYL9</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <sequence length="138" mass="15372" checksum="CCB856E96979349D" modified="2015-05-27" version="1">MTLGCTATLIDTYTLHIKDLSSSESVFQSKTAVTANYRTLNVNDESNPNSSKFGTLHPGLFIHCSVACPIDSLLYPHHRPPPPPPHCTHSSLKPTTAVVFFCAHKHPWLDDVTEFFSTAIQYEAIKRGYQAKKKDNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
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    </evidence>
    <sequence length="164" mass="18429" checksum="EC6C67B9B6F5702B" modified="2015-05-27" version="1">MSKSQNFTTTFTVLLLILYKSNERRKISSHRLRVKIKQIPLSQRTRRSALRQAGFLGTDGIEITNIQFSNKVSNRHQNMMEEVSDSVEQPMYHMQEEDDDDEAEIDQFKHAVGASQLTNAFSNKQSFSCPLAKPLLHTGDSLANLSPEDIDIVAAMGDALAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZZ7</accession>
    <name>A0A0D8XZZ7_DICVI</name>
    <protein>
        <recommendedName>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
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    </comment>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
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    <comment type="similarity">
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    </comment>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668">
        <property type="entry name" value="PHYTOENE DEHYDROGENASE"/>
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    </dbReference>
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        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
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    <evidence type="ECO:0000256" key="3">
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        <source>
            <dbReference type="ARBA" id="ARBA00038825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="304" mass="34280" checksum="D7B8C22680610A5E" modified="2015-05-27" version="1">MQAAYMARAGKRVCVLERRELLGGFKFSRASYLLSLLRPIVIEDLKLKEHGLRYHIRNPSSFTPIRDSKQKLLLGLDMNDNCKEIAKFSRRDAQVFPKYEDFIGLTARSLEPLMDDVPFNAHEKKWKMLMNRWRQRKVYQSGKAKNLSPDNTRLSYPVAVMNKWFESEVLKATLATDGIIGFAASPYDMGTGYVLLHHLMGGLDNRRGAWGYVIGGMGEVSKAIASSARSHGAEIFTEQEVVTILTDCGHVKGVRLTSGREVYANTVLSNATPTVTFENLVSKVEMSHLDSRSLPEEFAEHHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y090</accession>
    <name>A0A0D8Y090_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y090"/>
    <dbReference type="OrthoDB" id="5780528at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="116" mass="13375" checksum="3249E1E385D9FE29" modified="2015-05-27" version="1">MSNFIILKALMSMNLPSESDSNTFSRCIACNAIPLNRKDKFCRRCGYRFVLACRSCQADIRPYDRFCPTCGTRRLIIFDQIKYYLSTNSPYVVFATAIVLAGAWLALRYSLRHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0I9</accession>
    <name>A0A0D8Y0I9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0I9"/>
    <dbReference type="OrthoDB" id="5792800at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="426" mass="46747" checksum="0EF214F8F2039096" modified="2015-05-27" version="1">MSLTPLMGFLHPDNVNRMTDLAVELSSLAARSITKNEKDVARTVDEPREIPLGTRPSEILGQATTSSLEIRHSPIIQSETPLGNPVGAVQSGPLNSIKSVDESVNLPSPAISKPFTSLEDNPLLKLASSFLGGTTKESSQRGQRGELLDFGGIKDYVPGANNNFGLRKGPGCLPFVSEFMQVAYGNCQKVADEKAFDAWGDELKSAILTGQIDLLKASQETCRRGAERQQCGALRQAISNCDIIESLQIGAQLQRAMKRCEDVSGLLDQIFVYRTMLLISTLLVFSTVTAYPNTVESVSTQVAADPSKPILFASNSTNPANSTENSYVGLRASLENDVNYLRSGYQKLRHDFDEWMEAPYHRNVVVPAIVGVMAAGVALILYCLVRTVSQRCAKKFTRTRISYMSRDYNGEKKRMVPKRNESEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0K3</accession>
    <name>A0A0D8Y0K3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716278">
        <property type="protein sequence ID" value="KJH48141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0K3"/>
    <dbReference type="OrthoDB" id="10620710at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20425" checksum="E7D5C1A17899A8F9" modified="2015-05-27" version="1">MSQLYLLVPCPPIWIIVILNIIILILIVIGFIFILHANSEQLCITPTEHDLASANSLPQKKASEGRVVSKPRSVTNAFTFKNHGDDIGTDMSEDQLQDGNNHATKPFDPKLVAKNMDEAEQQHRIAAAKEVINPFIVNTQTNTSEPLSVIMKDSDTQSSIDLNSDVCRQKQKVDKKKRRIRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1J3</accession>
    <name>A0A0D8Y1J3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P5A-ATPase transmembrane helical hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_03833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1J3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1J3"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="27004" checksum="3B49958F55390272" modified="2015-05-27" version="1">MTVDSLVESVTTYRNLPLWAHLYAAPFGAFYACWFYIWFTWYGFNEYYELGFIGLAIIGVVQALFILSCHWFVGVKCALSCVYEKDPHKATHAKVIPTPNNGWSELRAGKTKLWFEFQKVHYTLNEASNTFSAIVFNSCKPLMYYRQSRGVKNDEELEDLKYLFGDNKTEMMIPQFWDLFKERATAPFFVFQFGRFFDRQTLNSALTSLAQQTSQRFAMRPRSEMILRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1R5</accession>
    <name>A0A0D8Y1R5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716197">
        <property type="protein sequence ID" value="KJH50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1R5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1R5"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="227" mass="25655" checksum="6FE7E20FBA4AE29F" modified="2015-05-27" version="1">MSHALIIIPLFSKFLSSSVLRKLSFKSIKAIRELDREKSRMEMQEKKVIAEIKKMARQNQMDSVKVMAKDLVRTRRYIKKFIIMKANIQAVSLKVQTLKSQDAMSQAMRGVTRAMQSMNRQLNLPQIQKIMMEFEKQSEIMDMKEEIMGDAIDDALGDETDDTESDQIVNQVLDELGIQMGEEMAGLPTAGEQIGVSADNKMKQAVAAGGAAIDDDLQARLDQLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2F5</accession>
    <name>A0A0D8Y2F5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2F5"/>
    <dbReference type="OrthoDB" id="5787624at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="10829" checksum="6E30FC39E35098FD" modified="2015-05-27" version="1">MSIFTIFVDSGAVGECRSECVERNLYKIVRVHLKEDLVMVGICKNTSTSSGSLSIVVPFICHRNHGIWIIDDSVGLSAFSETGWYVWLNSNISEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y346</accession>
    <name>A0A0D8Y346_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y346"/>
    <dbReference type="OrthoDB" id="5844120at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="193" mass="21440" checksum="E656C8F4F2EE3279" modified="2015-05-27" version="1">MASAKSQPIILLNHAIPYNPGGLMQMEQRLGCTFDHNLYAANRRRLNPRNTCDPQIESSFIQHFLLISLLVLRLLPIVCGALLLAKRTPLSESIAVFVEKLRPIQERSRLYMKKEQLNSQNNEKKSQLAQPPRVAGTPLPPIPSPTEIDHSISYNNAAYFSTSGAIGVASSKSSEISRIDAGELFSDKPSMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4W4</accession>
    <name>A0A0D8Y4W4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxiredoxin-like 2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Redox-regulatory protein FAM213A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4W4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4W4"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF31">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="216" mass="24097" checksum="3A418B2277F1DAD8" modified="2015-05-27" version="1">MEAFEYGVLAALGSAFLYANLPTRLTIGAVIPTVSYLSKAKLLPITDEAHVDQGKVVEASSLFSANPTLVMAVRRPGCILCRKEAAEISFLKPILKAKGINMIAVVHEIKGSNDFKSYFDGNVYFDKDGSIQRHFYGPNQRWLPLWMGLLRINSYVNIYKAKKAGFNGNMDGEGRLLGGVYLVANGKLLYAHLEKEWGDAVNIDDLRRFIEKCRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5N5</accession>
    <name>A0A0D8Y5N5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="13">HannoverDv2000</strain>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="154" mass="17698" checksum="05530D2813E79780" modified="2015-05-27" version="1" fragment="single">FQERRTGSCKWFNVLKGFGFIILDDTFEDVFSELKMEGFRSLEEGERVSFFVRTRHNGQRANALEAWQVGPEDENKSLIGSSIRPLGAKKDRMIRCYKCGRFGNHMAQRCKRVEADQKVCYGCGSADHLFNACPRLTHRTRSNSNKSHESVNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAE5</accession>
    <name>A0A0D8YAE5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAE5"/>
    <dbReference type="STRING" id="29172.A0A0D8YAE5"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20193" checksum="DB0F329CD9B3A437" modified="2015-05-27" version="1">MSSPMWRALESNPETMNAGLRYFDETCNAVSDSEASSTMNLFFMKQKIGNACGTFALFHALGNLEGVIDLGDGLFFDWLVEAKSLSPEERSDFLLKDAQLAAAHDETARMGETEETSEIEHHFICYIIKDDNLYEIDSCASHPRLLGKAFGKSLVVVAGEHIKKLMLKIGDVSFSAMALIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBH2</accession>
    <name>A0A0D8YBH2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBH2"/>
    <dbReference type="STRING" id="29172.A0A0D8YBH2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="17554" checksum="0016BADB3E5E2CC5" modified="2015-05-27" version="1">MFWSNPVWPGSCTISYRRNASPDFPGGPGRPGCPGSPGVPGSPRGPGRPIGAKPGSPGSPGGPGGPGGPGGPGGPKISPDGTNTPSFPGDPIGPGSPSSPGGPGSPIGPGGPGSPGLPLAPGSPVPVTIGPSGPCSPFGPGAQSKQNSAVIDSLDGSTSGPGTPCAPGSPSLPGSPSAPGGPGGPGGPVIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCC6</accession>
    <name>A0A0D8YCC6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCC6"/>
    <dbReference type="OrthoDB" id="5836476at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31128:SF9">
        <property type="entry name" value="DUF3444 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31128">
        <property type="entry name" value="PROTEIN CBR-CLEC-135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="56458" checksum="7C1B05B3D22E0DD3" modified="2015-05-27" version="1">MESECPTPYNSLYVPVKLRARRTQFNSTFRRKLYAACMELHVRSEKKNKKKQTVSDDNMSEQYVNLVDTKKGKDITRDDLIKSLAGKLREMKDSKINRKQRSSSRRRRIDKEIRDEMSRRTDDSSAGRNQKDGQNGVESAKKPTDEEFCEFETFSQKATERRRRGERARTDSESSSKSSNIELIKTKIKLYVKGLEELNFQISRIVPHPRNEPFEDFIVEKHFNEQQFDDLTPSKNRKKPDFDKPRKPRDALPETSRKTRTRRRDSDVNLKQALSHFPVTRFTFRLSLLLTWHCDIEKSIITDLVRSKSLSDFSTSASKGLVKDLDSIRNIMPNDNDRKVESTKEQPCQQSTNGPPIPQGLTGVAKSVYIGVCNFAKAEEQVEKRSDFRVYHQLVHRPLLDDLEQELPLIVVYKTANGSFRHYPIRRRKLGTSSYYYVDYGDPKVQAHASLDHLVRYYQINAQRHPENRQYADQFPWWEVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFW4</accession>
    <name>A0A0D8YFW4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFW4"/>
    <dbReference type="STRING" id="29172.A0A0D8YFW4"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="99"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="688" mass="79087" checksum="BC915BDDB8842BEC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5J4</accession>
    <name>A0A0D8X5J4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720510">
        <property type="protein sequence ID" value="KJH39795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5J4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="33" mass="3762" checksum="652232EE3DBBC939" modified="2015-05-27" version="1">MSLPKKPSQLSEKKPMSEDGIFGEKKKTVEQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7C8</accession>
    <name>A0A0D8X7C8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717214">
        <property type="protein sequence ID" value="KJH40438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7C8"/>
    <dbReference type="OrthoDB" id="5850569at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12924" checksum="A24C9000D2013DA5" modified="2015-05-27" version="1">MSLMTYDCSLEDSAYDIAKLCETNSIPNFDYTLSSNVTLQPPFKVDYLFYMNHDQMDKLGCAYFECSSPGFPFLSFVCKYGGSDVKPGTLLYKAGSPCSDCPDDCVDNSLCDYSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7S5</accession>
    <name>A0A0D8X7S5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ground-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717081">
        <property type="protein sequence ID" value="KJH40615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7S5"/>
    <dbReference type="STRING" id="29172.A0A0D8X7S5"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ground-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31967">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04155">
        <property type="entry name" value="Ground-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="471"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="615"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Ground-like" evidence="1">
        <location>
            <begin position="731"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="837" mass="93813" checksum="C26EE3A54E26526A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8D0</accession>
    <name>A0A0D8X8D0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Unspecific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719387">
        <property type="protein sequence ID" value="KJH39899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8D0"/>
    <dbReference type="STRING" id="29172.A0A0D8X8D0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF375">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10849" checksum="A408D4CFDCB0F997" modified="2015-05-27" version="1">MNLPHETRRAVKIDKWNIPAHTGIIAQISNVLYDSQVFPSPLTFDPCRFIDGDGKMKKIEELVPFSIGKRQCLGEGLARMELFLFISNLLNQFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8H5</accession>
    <name>A0A0D8X8H5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716996">
        <property type="protein sequence ID" value="KJH40843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8H5"/>
    <dbReference type="STRING" id="29172.A0A0D8X8H5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="218"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="519" mass="59397" checksum="27CB4F068BF47724" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X998</accession>
    <name>A0A0D8X998_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
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                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </location>
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    <feature type="chain" id="PRO_5002335685" evidence="1">
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            <begin position="22"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40647.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57304" checksum="4222680F00093973" modified="2015-05-27" version="1">MEIEAAISTFQDSPIECLSGWTELWLGRNQKSTLEMFERAINGRYFDGYIGKMAIYSSRQLANDMKAIAKDSLSVSFSHLPFHIEAIKACILAKEWNNALQAIQNSNLVEADNVYILFLLAVYTICSAGSKISQTLDELQSALDVYESDNHSLFGFIAQCLYRMAARNKTVLKFSRELLARANKKCRRVDYVVDELRVAVSLNDVREVTVKVKELMTMDSNDPYATLAVTLSNLMLGKVDDALAQLNFMKEANPAISDFAIYHFVAAVLAKYKDKSFEKFMKMINDSINIHIDKTQSIEFGIKYLRSLDTDFLMGIVYQIMDYAPLAPTKAPDDTLKTCERILNIIVDNCPGICQAYFILARCYFLHSEWDTADRMIEQCLQKDETIADAYLLRAEASLIKLMKGQINDADTCLNTGLSFNFSVRDSPLFHLIKAKLHKQKNELEKAADLLKSGLKIPQKEHTMNLLMQREAGNGQRMAIQLELIDCLQSMKQTVSFDRSYIVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAG6</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="192"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="25267" checksum="C28F795578E18101" modified="2015-05-27" version="1">MSFPDSIRLDPIRLPRPTLRETSIYNISNYQYMSNLLPPKDMSIMPMALRYDPLAFPEHLRARRLGDINMSVADDKPSFHAVSSVSATDMNNMPANDWNPLSDSEARDDNSHNTSQYEESPLPQPTQQFQSHSMLMMSSALNNNFVMSKFLGYQRFIFILTKYPALVMAMVALWYTTGRGEGMPKSTAETSYLYHVTMVAAFCTAVTCIVFAVINIDLPSVANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAV6</accession>
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            <fullName evidence="7">CBS domain-containing protein</fullName>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chloride channel 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF13">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain pair"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46846" checksum="2C806333F05E1D69" modified="2015-05-27" version="1" fragment="single">GRLPIHKYFFEIGEVARKEEAERRVRKAIETIDMHFQISRKEMYENQRAKSESSLLTTTHTSAPQLLQANIADVEEVDMKNRLPTRSNVPSGNIIVPHSPKPRQNSLTRRNAFCSLEEYNLHAIEKDEESKSEESSEENEHHKHHLTLHGIADYHTFVKSYVRQAKKYLHYMQFGHSKHEKLPINMYDLSQEERRQWETERLKEEVDLTDDIDTAPFQLVKQTSLFKIHSIFSMLQLSKVYVTEGGRLIGVVALADVRNALERSQEIVPKTEMASQIIPDQDTKYGKHPSSPQIIDILTPTLEARDFTVIKSTTLALTNDHQTTGMEGRPQSPQTNYLLQTRQRPSSAQLIISNDDEKSIFSEKHRRSLDEQRHEELVEAVAYLRRKSLASERRINNLQKNMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBA8</accession>
    <name>A0A0D8XBA8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716745">
        <property type="protein sequence ID" value="KJH41868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBA8"/>
    <dbReference type="OrthoDB" id="10071877at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="27788" checksum="A92859CF8394CC6A" modified="2015-05-27" version="1">MHHFCFWYSFTFSDTNSQTVAPISSPITSTKNTSSSIIASKATVHADEWVKASKKTKTSNRLKAGNATCFVGKDFYLDDSYSGWKDVELSRRRSSTLSVGSSVIARVIGRGGANINAIREATGASIEVEKQSAVRRDQHDRQICIRGTQETVRNATQMINGLIADNESSVTDIIRQVLRGNTTSAVPSESGSRFNNTETKTTAFVNTTANSLCSASAKVPVQPVTTNVWQQRMAARQREQQKQQVINGASNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBB8</accession>
    <name>A0A0D8XBB8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716744">
        <property type="protein sequence ID" value="KJH41878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XBB8"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040066">
        <property type="entry name" value="WDR31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869">
        <property type="entry name" value="SPERMATID WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="365" mass="41017" checksum="78481603220CA6D5" modified="2015-05-27" version="1">MRRVYLGSDLVMGNKYTSLSTCDPNDLLISKERQFIKKSATFSPPLIRPAIHSDSISAMVVVRPGMVITGSRDKSLALNNVDTGECITRWTGHDAEVTKLAFGNTVGNHFVLSGSRDQTIKLWQFHSQYPQKTFEGHSLGITGLSMLTENTFVSGSRDTTIKIWDVESTKRILRSTQMNRNLVTHITFNAVCKLIAQSSEDKEVKIWDPRNLELVTQLPRKHHIQMHCEFIDNNILASSSNGYNCDGCEISIWDLRMRKLVRELRGHEGSVPCVVGLTQQVTMKKLLMSVSMDRTVRIWNINDGVCAWNESISIDTDILQCVSFNDGHVVVSGGKGFLAHLRVQARAGKPYFQVLSTQKENIWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBJ3</accession>
    <name>A0A0D8XBJ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716896">
        <property type="protein sequence ID" value="KJH41137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBJ3"/>
    <dbReference type="STRING" id="29172.A0A0D8XBJ3"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF29">
        <property type="entry name" value="DICER-RELATED HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="198" mass="22110" checksum="3A6138EDE586DBB6" modified="2015-05-27" version="1">MSRLLDSIDRRTFEETPFSLRNYQKELCENAFAGNNTIIAAPNGSGKTIVAASIIKNHLGNSRNSGKKMKVLFMTPNTVILEQQATCLRKFLGHRYEVFAVCGSDNVPLRQMIMMKDVVVCTPQLIVNLLKSDESDNAESCCTTFDISTFTLMVFDECHNAVKNSPYAGAFFNVISTPIIGAYMRLVHLLTIRNDIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBQ7</accession>
    <name>A0A0D8XBQ7_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Protein phosphatase 2C</fullName>
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        <name evidence="6" type="ORF">DICVIV_12941</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716907">
        <property type="protein sequence ID" value="KJH41094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBQ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XBQ7"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="421" mass="46970" checksum="CF58A91AF316901C" modified="2015-05-27" version="1">MSRRVLQEWRRTIRNLRWNADTHLRAHERSVSVDQDSIVRIDTCQLAANNPIEDFYSAAKCLSSNAFLFGVFDGHGGPSCSRHISTSLFPYICASVLQKHEVKSLPLDHRLEWIFSSADAHLPNLFIETHLENILACHKAFIENKDLCTVRDALKFAFESCDEDLCRAALPDSKGHIDRQEKQFLLKPTKASVMTAASGSCATLAHVRGQNLHVANVGDGAAVLGVVHANGSVTARQLSRAHCIDNVEEVVLEPMGSPAPSNLHTPPYLTVAPEVLYHKLTPNDKFLVLATDGLWEWLDPDTVVRLVHDHALGAMTLQPYQPKSGITLKQVLLELKERKIGAQSHKKPIDENCATHIIRHALGGVSGGQTKQYERLIDILQIPPGRARNYRDDISVIVIHFNENYLKQEHNSVQQETPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC48</accession>
    <name>A0A0D8XC48_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716848">
        <property type="protein sequence ID" value="KJH41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC48"/>
    <dbReference type="OrthoDB" id="10033661at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="83554" checksum="9A36CA1CBBB69E56" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDB3</accession>
    <name>A0A0D8XDB3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716646">
        <property type="protein sequence ID" value="KJH42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDB3"/>
    <dbReference type="STRING" id="29172.A0A0D8XDB3"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="9128" checksum="3D2D42BC57BA3B92" modified="2015-05-27" version="1">MGSSFRKFGMLVWFQNRRSKERRLKHLCNYLRHYEQCGYFPPPIHFTAETGISSDVTSFSHYLSATDGQFDEDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDM7</accession>
    <name>A0A0D8XDM7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717129">
        <property type="protein sequence ID" value="KJH40546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDM7"/>
    <dbReference type="STRING" id="29172.A0A0D8XDM7"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="49171" checksum="9D0EB69F08750CA0" modified="2015-05-27" version="1">MLFLFASHVNVKVKGLEMVFESLVADLLNRFLGDFVDNLDASQLNIGIWGGDVKLDNLEVKETALDDLDLPIKLKFGYLSSLVLKIPWKNLYNESVIATIDGLYLIVVPNKGVVYNEEKAMKNAADIKQKTLARLEEARKNRRKPPDSNQDSFTEKMITQVVKNLQVSIGNIHIRFEDKYTNRNRPFAAGICLEKLDFQTTDENWVPTIHRDAVKIFHKLVLLDSLSIYWNSDASLFSDTENKLEIRKKLKESISRQETTFSVLKPIKMEAKLKLNQKPETDGTNWSVPKVDLNIDMETLELAINKYQYQDILLFLEAQERWRFAYNAILEEKVRRRRNNWSWSMMSAHRKLVRDYRDAWLKYLVERNPNASVTDVIKKAEQKLDVFNLNIARQQAEMEIDRKGLKRVEDQPQGWLSWGTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE27</accession>
    <name>A0A0D8XE27_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716613">
        <property type="protein sequence ID" value="KJH42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE27"/>
    <dbReference type="STRING" id="29172.A0A0D8XE27"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="315"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="604" mass="67483" checksum="ACE9F6E72F4A47B6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE66</accession>
    <name>A0A0D8XE66_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716716">
        <property type="protein sequence ID" value="KJH42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE66"/>
    <dbReference type="STRING" id="29172.A0A0D8XE66"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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            <begin position="128"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="400" mass="46108" checksum="621F8DBE06009479" modified="2015-05-27" version="1">MLRPLILLAVCTITFSFLYHEKFHHNPLRKNVVSVPLLRQSTLREKLFEVGSWNIYERKRTHYQKKLLAKYSSNNIVKLQFASEIDELLRNYMDAQYFGTIQIGTPPQNFTVIFDTGSSNLWIPSRKCPFYDIACMLHHRYDSSASSTYKADGRKMAIQYGTGSMKGFISKDNVCMATICAERQPFAEATSEPGLTFIAAKFDGILGMAFPEISVLGITPVFQTLIDQKKVPSPVFSFWLNRNPNSELGGEITLGGMDSRRYMDPITWTRVTRRGYWQFKMDTYMIPCDKVPNLPDISFVIENKKFTLEGKDYVLNVRKTDWMLECNDCWKIHLPFWFHGYGFSGKIGELWILGDVFIGRYYTVFDMGQTRLGFAQAKDENGRPVPPAVLEFKPFEVSKY</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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            <begin position="182"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="217" mass="25223" checksum="7C3DD0166DA68098" modified="2015-05-27" version="1">MKHLFLLTINFAAVFGEKTSVKDLSNGFRNEIDWIDWNVAIGVAKDLHKPIFLLIHKTWCGACRGLKKEFSASPKMPELFELSKKFVMVNVEDDDEPEDEKYAPDGGYIPRILFLDTSGEPLQTNNEARYKNNKYFYPLIPQVIDAMERALIEFEAKEQNNEKTEKSEEKYEEITSENAVGKSEERRSSDHEKKEKDTDPEKKAKNDKRQKVEKEEL</sequence>
</entry>
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    <name>A0A0D8XER0_DICVI</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="748" mass="85484" checksum="67C50EC922D11CE8" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8XET7</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716700">
        <property type="protein sequence ID" value="KJH42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XET7"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="16604" checksum="5619C8204D850D6F" modified="2015-05-27" version="1">MNVAWFHQSSSDCRGCGETFKYSCVATFLLLSVCEHHIVKTHCKAGGNRYSIFETISSVIEADAICEALEKLSFASSLINVKKSEQRIFGIRKNGFGISCTDPGINQTLLESVLDIGEFKEIFVYRNSGKSKEEHLNWFQILLKGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEZ9</accession>
    <name>A0A0D8XEZ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716689">
        <property type="protein sequence ID" value="KJH42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEZ9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13515" checksum="0B4FA362CB088652" modified="2015-05-27" version="1">MDSVIDLKANPSLESYPVVTVTLCSSVCYPIIFYKTKTKLATNRCFKVIAMWTTNTKTTTYPSKRKAGTILINDDVIALLYYFRKFVNFTVYQLISKKDNRSKSNLFRNKQKFSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFG5</accession>
    <name>A0A0D8XFG5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_10667</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KN716571">
        <property type="protein sequence ID" value="KJH43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFG5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFG5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000209">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF77">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="220"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49990" checksum="93D0F712F3DAA22B" modified="2015-05-27" version="1">MKKIAGKARLREKDYLSLESVMAEFKLSNNTLRRMMSHMSDNMDRGLEGGLDASTIAMLPSFVPELPDGTERGKFVAMDLGGTNLRVMIMEIEPGEEMRTKQFNTRISNAAMHGSGEQLFDYIAKALADFLIEKNLANDNLPVGFTFSYPCDQTSLRSAKLLRWTKGFTATGVVGEDVVKLLEEAIERDGRIQVEVVALINDTVGTMVAAAYEANGECDLGVIIGTGTNASYMENTKAIVHGLENATVEYPYKQMIIDTEWGGFGDCGEADYIFTQYDRIVDERSDHPGVNSLDKLVAGMCMGEIVRLVLEKLCTHKVLFSGNGSKMLYTIGSFPTKYISEILHDDCGSYSNTRQIMDELGVDDYTFSDMLLFREVCLVVSRRSAYLSAAAIACVLNRVRRPKMTVAIDGSTYKYHPFFNHWVTEKVKELIDPGLEVREYLYFSSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFT3</accession>
    <name>A0A0D8XFT3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716647">
        <property type="protein sequence ID" value="KJH42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFT3"/>
    <dbReference type="STRING" id="29172.A0A0D8XFT3"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="DAACS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF110">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
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    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
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            <end position="218"/>
        </location>
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            <begin position="230"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="391"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="457" mass="50154" checksum="A015C004503C8DA2" modified="2015-05-27" version="1">MDTRKSITRVNNFFRNRWCFLGFVMRPSNPTPQVFHSWKLSNADDMGSLAFIYYIATTFIAVITGIILVLSIHPGDPDIKKDIAEGTEGRNVSTLDTLLDLVRNMFPENIVTATFQQVRTKYVSARPTILQRNHSIHSDVVKNATTFKYALEYANGINVLGVIVFSIAIGISLSQLGAEADVMIQLFIVMDKIIMRLMMVVIWYSPIGIMSLITGKILEIDDMAETARMLAMYMITVLLGLTIHSFISLPFLFFFTTQSNPYKFMSGLIQALCMALGTASSSATLPLTFKCLEQNLGVDRRVTSFVLPVGATINMDGTALYEAVATIFIAQMNSIHLTTAQVVTVSLTATLASIGAASVPSAGLITMLMVLTSVGLPVNDISLIIAVDWLLDRVRTSVNVLGDAFGAGIVYYFVEEDLMENDLQAMSLSSMDGDFSSEFSSGRFSKLRNTSETSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFY3</accession>
    <name>A0A0D8XFY3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716553">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13929" checksum="22CE3AF3E51BC59C" modified="2015-05-27" version="1">MEGMIAGIAPSRRGAENPELHPPIHDDTRRAVQIVVVRGHRVDVSSMNSLLSLSRKFMFFSPPTLVVCTLRVRLTDKRTADIGYTISSSSTNDRRKTNQPCVPCRSHTVRPRFMKKSMDCHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG05</accession>
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    </protein>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716643">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WDR75"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="46481" checksum="4F8F97AE2673C4E7" modified="2015-05-27" version="1">MEDDTLVRIAKLPAGLRYKQITVENKYVAYCSGKEVFVLPTEENSSTSATSFTFSASSARSTSHVSQKGIHDSSYTLHWHKVAPSIALTPFGSLLSAGAETVLCKFTLSGAGRPSMLPRLGAPVRDIAISTDASHLALIFGILIFPMVSEDNTLHVVLTSTMTILSSMQTVVTCERSFTTVFTTDPCMPGTVVMNGKPGSLQWIQCADTFTLRQVSFSLENVADGDMSFAGIIQTFPDVEQVFFSNTVVVTLERLINFDEDHKRLRFWERSSKDLLIVRIRDSFMVSKDTISISGCKNPLCGDDKIFITTMGNGKADVWITCEEENRFKLDPVRQIDRHQSLHCASSIHNKMWAAAYSGGEEGTDVVTSRDAIRERIAIYILQRNNINVSSYVGVHGFQLKNSAPLLCQIGVIRAAGKLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGE3</accession>
    <name>A0A0D8XGE3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR2 complex protein MIO zinc-ribbon like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716626">
        <property type="protein sequence ID" value="KJH42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGE3"/>
    <dbReference type="STRING" id="29172.A0A0D8XGE3"/>
    <dbReference type="OrthoDB" id="5855440at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="2">
        <location>
            <begin position="483"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="585" mass="65928" checksum="2550161FB8DC94F0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGH2</accession>
    <name>A0A0D8XGH2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716618">
        <property type="protein sequence ID" value="KJH42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XGH2"/>
    <dbReference type="OrthoDB" id="6273691at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13157" checksum="91281E93FAB26D53" modified="2015-05-27" version="1">MNGWAMMKPDECVDERFDMKSFADKYIGANGQPSHKRYIMYFSSLLSGRIRVNPAPIYLRRITVSRLAGRVLSFKIYERLQPNFLIDSGAELLGNVDRIDGRVVYGAFELSSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGK8</accession>
    <name>A0A0D8XGK8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716809">
        <property type="protein sequence ID" value="KJH41511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGK8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGK8"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="399" mass="44153" checksum="EF1934D7E52963EB" modified="2015-05-27" version="1">MGPDETLCLKVDDVGKGDEGRQNAEWYNAIMSVLIPSRVLRLGRPIQPQEFFECAWDVEVVNAPKIKRPGRSEEPLQNICVRLPEIAGQKRLCFYAHTIVICKRRIEPTVCGTPPSGIPPFHIDDFIEIPRKCVAFFGCQERFFLMRLGRGAPMGASELWAQCDSEEAALDIHNKLNVIIERESEKKRKMNNGIKDGSWGCCKKTFILFVVGAFYTGEVFEMFSVIMPPGLLSLRSYHTHHRERPHTQPLRQRASSFFNGRVGSLSCASNNIAGRKTSDSSGPGVQALGNRASSISHDYRTQSGNNLNVRNLMSVFPNQEVSTSLSFADTLGVYQQMKIPSNAPSPSSNPTSDETENSGSTICAESIDGSQCGVTSNLQHLLEKKGGTCEVFVVSQLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGV9</accession>
    <name>A0A0D8XGV9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716604">
        <property type="protein sequence ID" value="KJH42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGV9"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15318" checksum="641DA911E2477796" modified="2015-05-27" version="1">MAGMTSSVLGDIDSFMQEMENESKAHPRSQHSAYDDHDHSLHNLATHNNHTNHQMKMWFHGGWNEVILFESWSIDSLSGLILSFIAIFAMGAIYEEKMESVFGRLQVIKLHCKTMLTETIRMTTFIIQQQPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHE9</accession>
    <name>A0A0D8XHE9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KN716505">
        <property type="protein sequence ID" value="KJH44033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHE9"/>
    <dbReference type="STRING" id="29172.A0A0D8XHE9"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="8">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="54597" checksum="80ACE36669C4AA19" modified="2015-05-27" version="1">MSVPLLGQSPPTEAHSQHNLNAIGEILNRKTSVAQILSKTVEGLNHAYELRDSSPEDLIFDLFKMPNRDEASISKLIKVLKSFGLRESDPRLRPMMDKMKSFEDDDDDARNFLLSRDKFKECVHPSMQLISQALRNHLIIPSWGEFCSQIKAIFEKCSDIKDGNVATYIPQLARKDPNIWGLSICTIDGQRVSYGDSKVPFCVQSVSKAFNYAIVSSDLGADFVHSYVGHEPSGRLFNEICLDANGKPHNPLINAGAIIVTSLIRNHLTMADRFDFVLNEYKKLAGGEHIGFNNATLGLREELDLYFQLCSLETTCDTAAVMAATLANGGKKFSYSYFLCFLLLSNIQLFDFHVGGGVCPLTDELCIHPRSCRDVLSLMYSCGMYDFSGKFAFQVGLPAKSGVSGVMIVVVPNVMGIALLAPPLDKMGNSARGVAFCQKLIESFNFHNYDSLLHADSKKHDPRRRIGNRDTELVVFLLFAAKNGDFDVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHM2</accession>
    <name>A0A0D8XHM2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716578">
        <property type="protein sequence ID" value="KJH43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHM2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335641" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="13854" checksum="5714DCC8FC701D13" modified="2015-05-27" version="1">MIRLIIFFSIVRLNCACTSNCGGCGGSLLPPLPSLCLPQLKLPPLLSFPSLPSACPPPSYSCGCAPSPPPSPVSSGCTSAQACPQPGPPQYAPQNLAPQNVAPQIVSPQRYAPQTYFPQRSFQDVGAYPIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI59</accession>
    <name>A0A0D8XI59_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN716557">
        <property type="protein sequence ID" value="KJH43454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI59"/>
    <dbReference type="STRING" id="29172.A0A0D8XI59"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000100">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="36529" checksum="25CC3CFB94D52782" modified="2015-05-27" version="1">MGTGEREMGWISDTYAQTIGHLDRDASACITGKPIVAGGIHGRVSATGRGVWKGLEVFAKEEEYMNKIGLSLGLAGKTVIVQGFGNVGLHTMRYLHRAGAKVIGIQEWDCAIYNPSGMHPKELEDWRDQTGSIKDFPGAKNFEPFSDLMYEACDIFVPAACEKVIHKENADRIQAKIIAEAANGPTTPAADKILLARGNCLIIPDMYINSGGVTVSYFEWLKNLNHVSYGRLSFKYEEDSNRMLLKSVQDSLEKAIGKEAPVQPNEAFEAKIAGASEKDIVHSGLEYTMARSGEAIIRTARKYGLGLDIRTAAYANSIEKVYNTYRTAGFTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ10</accession>
    <name>A0A0D8XJ10_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJ10"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="47412" checksum="472FE980523B2FE6" modified="2015-05-27" version="1">MHKIYSRISRFITGKGEQFRSFSAWIDAEVCESNASHITDAEKLFICPKVQKILKEVTGMDLEGKVFRERREKFQQRSHFALMTNERLSGTMEKMRKEAQYFLSLVPLKEPRSEKTCVLSEDREILAFDTAKFVFTDITFDATDQDRTVVVREVDGTLRTATPEEHDRMNRVYYEKPNRPIFPPPVFSDPHLQVYFRNVDTVVVYDFNGRTHSLEKNMSLFSIGPAGSMSRMTRPMSSRSTAWKTRISMALQLVKCVFNRVVKNNDFDVLYSTRHFGTLVFYLAFNQNIFPLLNYFGGQGRIHDCANLVRLQKTLIPDWRLSINSADTDLQIVMDFVKQNNQRCESFKDLSAFLNEGIVKSCISQEVEHRVNSRTKSKITIDAGNIGDSSGPLGELSEQYNVKVRGKLLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJM9</accession>
    <name>A0A0D8XJM9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716451">
        <property type="protein sequence ID" value="KJH44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJM9"/>
    <dbReference type="OrthoDB" id="5863461at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="494" mass="56304" checksum="765EA4522F6AA198" modified="2015-05-27" version="1">MHRRGERDEAPHFISGHWNDLYRRVIALNALVFSAGELHFSFKKVLSFERHQMEYSDCNDNLYTVFDKNVTLFSEMVFGHSRTTFFKHEHTLFMDTGQIIGVLLLTLLIRIKTSFQLAIGASYIICPTLHFFKNKMSIRFSVFCSGVLIMIIRVPIMMHCVESLPEHLRLYGFASMFIMAPVFNSWYRLYARLVLLSFFWLHTMTAVIIFISCVLHIWFAPPSIMDTLFHLRTAALNEALKGWIPKDQVINTDDLVDCVLYRGPAFSSEMNAFQYLSQFGVFMRKTIICTLLLPLGPLLIDAAYLYRKNHVIFGEFESSFFSDVLKVFGFVLVVVLHLKFGRRCTLAIAMISSIIALVTLLCTRLEIINICSKTQIPRGWRLILAALAYSLVVIFGSVITVVARLTLLEHVPTSVRSSIAVAFVFSTFVIITYREISKLAPKSYPNGTIIIALGYALLVAPFSLFIDDSSYLPINSADVRAYTYVVLFKNSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJU2</accession>
    <name>A0A0D8XJU2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ser/Thr phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716444">
        <property type="protein sequence ID" value="KJH44843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJU2"/>
    <dbReference type="STRING" id="29172.A0A0D8XJU2"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="33842" checksum="83BC33ECF574FA0B" modified="2015-05-27" version="1">MVFLRLQRRPIFRLFSSFYPILLILAIAWGEILNYYCWRFFWNIPQSHSDESLGILIVADPQLIGYRNENHMIGPLTRWDCDRFLSKGFAHAVSATSPDLIIFLGDLFDEGVEAHENEINWTLTRFGNIYNSEFPKIFISGDNDVGGEMGPVQSLLTTRFRRLFTNSFPTSSRLYNQLTVTEVNLMNSEVHEISSPSASPHLNVILSHVSFAYHSYYDSRKFVETLKPDLVLSAHDHKSYAHWLHRINGDLINTTDLTGIYEVQNTIAGGGESVVEMQSPTCSYRFLPAFPSNDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJZ2</accession>
    <name>A0A0D8XJZ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716440">
        <property type="protein sequence ID" value="KJH44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XJZ2"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="467" mass="52444" checksum="EF32474D1B98FB1E" modified="2015-05-27" version="1">MSCKKTQCGGPGYACPKEALKAPKEKVIFVTCPHTNPEVGHDKLVAVDVDSNSNTFCQVLSSVTFPNKGDEVHHSGWNACSSCHNNPSAKRTHIILPCLNSDRIYIVNVEDVYNIFLEKTVEREQLSRYNVSTPHTTHCLADGNIMISTMGNNSGDHEEDMANVFIYSIPIGNFILLDGKTFEPKGCWLDSNTTLPFNYDFWYQPRCDVMISTEWGTPNVIKKGFDLKHIAEGYYGRSVHIFKWSTRQKLQTIDLPEPEGAIPLEVRFLHEPTSPFAFVGTALGSSLFLLHPENEDSNRYAAKCVVKIPPKKVEGWILPEMPSLITDILISMDDRFYTFPTGFMIFLGGSIHTESGVKIIHDDEMKDAPPPRYVKGNLIEGGPQMLQLSLDGRRLYVTTSLYRQWDAQFYPKLLKSGAVMMRVNVSDDGTMTLDENFLVNFGSMEAGPYLGHEMRYPGGDCTSDIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK72</accession>
    <name>A0A0D8XK72_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_09800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="KN716493">
        <property type="protein sequence ID" value="KJH44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK72"/>
    <dbReference type="STRING" id="29172.A0A0D8XK72"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="349"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="602" mass="68282" checksum="8011080953FCFCA1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLQ7</accession>
    <name>A0A0D8XLQ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+ channel tetramerization domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716406">
        <property type="protein sequence ID" value="KJH45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLQ7"/>
    <dbReference type="STRING" id="29172.A0A0D8XLQ7"/>
    <dbReference type="OrthoDB" id="5864281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000214">
        <property type="entry name" value="Potassium voltage-gated channel protein shk-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16679" checksum="8BBDD8FC500C35BF" modified="2015-05-27" version="1">MDVDEENGDLLLDHSVRSSSPRRGSPQSEERASSTDLITINVSGLRFQTYEKTLSRFPNSLLGCKMKREKFYVQDSDEYFFDRHRSAFESILYIYQSRGRVKRPESVPIDVFLREMRFFQMGDDLIEEFWISEGYEKPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMH6</accession>
    <name>A0A0D8XMH6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Putative sodium/calcium exchanger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DICVIV_10390</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716544">
        <property type="protein sequence ID" value="KJH43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMH6"/>
    <dbReference type="STRING" id="29172.A0A0D8XMH6"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CaCA"/>
    </dbReference>
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        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="436"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJH43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="809" mass="90305" checksum="917FBC5A91738744" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMJ0</accession>
    <name>A0A0D8XMJ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="T-box_DNA-bd"/>
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        <property type="entry name" value="T-box_sf"/>
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    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
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        <property type="entry name" value="OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9666" checksum="52FD162ED2C45A3A" modified="2015-05-27" version="1">MLDLRDLNMRFLNHFPIASPNVKITKHTSGEAELPCRTFVHPDSPASGAHWMKGSVSFDKIKLTNNQLDQNGHKYTQLVSVDSCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNQ8</accession>
    <name>A0A0D8XNQ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716411">
        <property type="protein sequence ID" value="KJH45377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNQ8"/>
    <dbReference type="STRING" id="29172.A0A0D8XNQ8"/>
    <dbReference type="OrthoDB" id="5791188at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="404" mass="46192" checksum="A8C9E42204F10EBA" modified="2015-05-27" version="1">MHKENRLLRTANQQRDIVQAKDMYEILVHHDVDGEQNPETTYITSRWSGEERVPSGELHISVIISCETSSTSEQMILNSVEDSITIEISMDLHYDITHLSDSGNRVLARITPLECHKICWQSSLVAQVDTMCFISDMSSECHIIDPITYITSLREMKRYTVKQRLSGFELIVETELSGDTEKAFIVLSIFNLAKNSSETLSKKFSTDSSNGTFSVPLSSDTVYAVEYKYIKVKPFHFSTKKHFLIEISLGNNSEPSYPLVEVEFHMGNDTRTESGFIPSSHVTFTRSELYSDREIHLHLEPFCSEMQNTTWIFSDQKTSHHVDVTPAICSQTNEPKFCQYENYTKCSSYLCYSTSVVINDNEYSGDVRCFDFTQQLPINSNSNRLPTFTYLLTALFLVISIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP86</accession>
    <name>A0A0D8XP86_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716400">
        <property type="protein sequence ID" value="KJH45567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP86"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="21444" checksum="3FD9F07508CB6BE2" modified="2015-05-27" version="1" fragment="single">KTIYDYYSNLFGSHVRLTPGNERKDDYVVSNVLPSEIRHAISSVRNCTAPGPDRIRPEHLKNLPPVLIKTLARLSTHYLSECKVPNEEQPREQAGFRKGFSTMDHIHTITSLIEVSREYKKPLCLTFIDLKKAFDSLDTEAFMEALTNQALPTSYIKILRELYKNFTTKIPPFYRDIIIKLCAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPB5</accession>
    <name>A0A0D8XPB5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716356">
        <property type="protein sequence ID" value="KJH46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPB5"/>
    <dbReference type="STRING" id="29172.A0A0D8XPB5"/>
    <dbReference type="OrthoDB" id="5832955at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24429" checksum="0F70BCEE1E998A5E" modified="2015-05-27" version="1">MTDSEFNFDERVKSKFGNLDDDCERVVSHVACVTIESDSLPESPNMPRITRKKRRLVRRPRGHKMDIDFQPSTSQNCRMEWDGAESCLSSTSESECGNCAADADDEQSDWVGYARSVTEGDFVFKDPSEERRVRRLQRRQQMSQIQRRLERFAFEGGSGEMSIEFRIKDRLNSFQFNRMLLHYRLEVVKRQRGALVIRRRSNSCNKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPC1</accession>
    <name>A0A0D8XPC1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716491">
        <property type="protein sequence ID" value="KJH44201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPC1"/>
    <dbReference type="STRING" id="29172.A0A0D8XPC1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="29449" checksum="D92DDDD91075A284" modified="2015-05-27" version="1">MATFVLKGHRSIVNHVRYSPSNRIIASCGVEKIIKVWSSLPIPFSYDKPRIRIKKAFFSELGFDEGAAVDDTAEDLNMLNYFDQLDSLSRLHAEDAPEESFNEGRDTGLENYVVNVDMEGLRAHLMGLETSDESDSDSDGNDYDVALADDDVDGGDAEDEDTFRGSLRALRRRRWRMIRNHERENHSNIVEYGPSPSRYDGIEHGDRETTTDDENEGPRKRLKQSITSSDSSDNEFAVCEGGIPVDVWPVVTHFAMIWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPI9</accession>
    <name>A0A0D8XPI9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_07485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716352">
        <property type="protein sequence ID" value="KJH46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPI9"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF30">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="19144" checksum="BA4D69E4079246A8" modified="2015-05-27" version="1">MSHDHHHDHVDQSSGHTVVIGGTANLDHSKGDYSSHFHPMAFHFGNNETILFNFWKSSDIGGITLSCIVVMAMCFLMEFVRFVRIYRSAKNSTSIQDRIRFDVTISSYALFDAFLHFTQLTFSYLLMLIFMSFNVWLCGSVLIGEVGSRFLFSILFPYLESKTTSNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPP6</accession>
    <name>A0A0D8XPP6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716392">
        <property type="protein sequence ID" value="KJH45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPP6"/>
    <dbReference type="STRING" id="29172.A0A0D8XPP6"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053326">
        <property type="entry name" value="GPCR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632">
        <property type="entry name" value="FMRFAMIDE PEPTIDE RECEPTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47632:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="559" mass="63510" checksum="0F2B0CE5BD23A138" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQE4</accession>
    <name>A0A0D8XQE4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQE4"/>
    <dbReference type="STRING" id="29172.A0A0D8XQE4"/>
    <dbReference type="OrthoDB" id="5863201at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="160"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="469" mass="53626" checksum="5DDCAEC83075E0A4" modified="2015-05-27" version="1">MEVATNVQENDGKLDDAEDAEKDLELLQVKARIQLPLDNVNEKMLANLEKHEWYHGCLPYEDIAGLLKDNGDFLVREVGPEGDRTAMACVTVKWNETVQNFPVHSLCKGNERQYTIDGNNKSDDVMKLIQNHLNKIPIGDNILLKRPIPKQRWELTSNKVKLQKKIGAGKFGEVWKGTMIEEANKPPIDVAIKVGKISNENKAMIDEMYKEARLMRQYKHRNVVAFYGVVIDNSGNVMIVMEMIYGGGLNDHLKKQKVEVKDKTSYSIDVAIGLLYLHSKGCMHRDIACRNCLIDVRANIVKISDFGLSKQADSYNIPQDEPLPIRWQAPEVIATRVYTMKSDVYSFGILLWEIFNDAEVPFKGIDNKTIKSKIGDPKFRPPLDPSIPLIIRRVMKTCWRAEPTRRPTMELLAKYLIHSPADSAPNTEHTEGVLRKAKNSIINSMRSKKRTRSNDRYRLLSLMKERRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR09</accession>
    <name>A0A0D8XR09_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716363">
        <property type="protein sequence ID" value="KJH46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR09"/>
    <dbReference type="STRING" id="29172.A0A0D8XR09"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10888" checksum="41D29F4813A014CC" modified="2015-05-27" version="1">MIDLVQDRDVVEALYRHKSTLETLFRFMDKDNSGQVSMQEFIDAIQVLGKYTKRTLAPDYIAQIARSIDFNKDGFIDLNELLEAFRIVDQQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR20</accession>
    <name>A0A0D8XR20_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716363">
        <property type="protein sequence ID" value="KJH46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR20"/>
    <dbReference type="OrthoDB" id="5867416at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="195" mass="22949" checksum="775217C5D3E640A9" modified="2015-05-27" version="1">MSHITRRLSQVALVFYNNWYKMVKDKNEGTLRNAIIFDKIGSTPADYNMSWNTWFQYKVAFRGNATNFKTLSFNMKSSEFEFFYNTQVVHTKHTLKSGDVYFNTMKLSYDVENFALFSTHMRKCPTIITQVNRSFPFWIPGHKIPLTGIRAHEESDTTTLRDVIIAVMFIVIYYAILVNILLPIYFGRLMQSVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR37</accession>
    <name>A0A0D8XR37_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716362">
        <property type="protein sequence ID" value="KJH46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR37"/>
    <dbReference type="STRING" id="29172.A0A0D8XR37"/>
    <dbReference type="OrthoDB" id="5828965at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="43572" checksum="5CC44A2FEDFC62ED" modified="2015-05-27" version="1">MVITKNQAVLSYYFRHFFSHRFHPDVMEQSLLVFETIEDSVEEMEELQGDLVGILVAATSSFYNNNDLEISVDDEVFTMFEQTAIDHATHSIKQIRYLENADLHLEQIHIYESSSLEQPQFPSSQSIISRIDWSQTASKYPPQPFETFLLDVPVSMRRNLRHIYSPILSCREFGARLSDIQDATNMELHEIETGIEYLTKNSQVITVGVEVQRWVAAEFAKAWCVKVGHRLTSPRPWTMPSGDICPATVRWMGESVLMMIISSPGITLKEVCSRFEFALQPVAVHDLITVLELAGCIRLLKEVFENMSLSSLFQRDVPQIEITYLLPTVDCIERFSRIFGGISLLPAMTGRSDSDKLETQRSSAVDEDLGELNLTLPILQKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM4</accession>
    <name>A0A0D8XRM4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
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        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5843165at2759"/>
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        <location>
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            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="687" mass="77009" checksum="DFC88614F2E8E389" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRN0</accession>
    <name>A0A0D8XRN0_DICVI</name>
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        <recommendedName>
            <fullName evidence="12">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="19" type="ORF">DICVIV_07511</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
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    <keyword evidence="8 14 15" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="339"/>
        </location>
    </feature>
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            <end position="489"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="27"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="183"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH46437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRP5</accession>
    <name>A0A0D8XRP5_DICVI</name>
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        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="9481" checksum="47888F456842753D" modified="2015-05-27" version="1">MSRFLENYYSQLWDFPTKKRWIDKPIVFDYNDEQALTNKIDEHQYNLKWKYGYYAIGRVTNITCISEDHRSITPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSG5</accession>
    <name>A0A0D8XSG5_DICVI</name>
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    <gene>
        <name evidence="12" type="ORF">DICVIV_06413</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="164" mass="18960" checksum="38DF3CD9B0759A5C" modified="2015-05-27" version="1">MVKMCASGKRKVKATKAMPTKWRQMDDRQRTFILAHLSIPREIVKCCGPCFKRISKKLDLLFAGDLQEEMSKFELEVHQTWQSEENLIRVIAVFHKVGFEFPCGHFSYHPMYSANSLCFGSFLLPCFHFSLIPSPSSKKKELFRFVFNVVNVVNFKSDCVRAGK</sequence>
</entry>
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    <accession>A0A0D8XT26</accession>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
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    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF69">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH48022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16740" checksum="8BCA00FA33E44BAE" modified="2015-05-27" version="1">MRPPNSDFIKVLRIKVLIRSNMLSLWGTEEVTVEHNRGLRLRRANGEERILQFPIKLDLERPKRPRTIFSDYQLRILEEAFKKNDYLTGEDRLALAIRLGLSDTQFLATTNMLAMFRGIIGFVQMYNFSNYYATVCSHLKTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWR6</accession>
    <name>A0A0D8XWR6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required during maturation of the 40S ribosomal subunit in the nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716274">
        <property type="protein sequence ID" value="KJH48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XWR6"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="5">
        <location>
            <begin position="281"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="6">
        <location>
            <begin position="556"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="871" mass="100393" checksum="2146A44F0FB2D96D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXW9</accession>
    <name>A0A0D8XXW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716238">
        <property type="protein sequence ID" value="KJH49335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXW9"/>
    <dbReference type="STRING" id="29172.A0A0D8XXW9"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12558" checksum="3D2BD371EFF23E05" modified="2015-05-27" version="1">MLYKIKGHTYAAKWLWNRLIVGPSFNFSSMRFSQGSYYCPSVACPYFRTVQNLEHCTVLSEVEYRLLHFTTNRPKNGSSKVSNLNVSGTILYFRSKRATMGRFETVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ47</accession>
    <name>A0A0D8XZ47_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cwf19-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ47"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ47"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="12443" checksum="2DD9B7154C7AEA28" modified="2015-05-27" version="1">MECEDEYADNKKLIEIKDLRRQIPKNFSYLAVDFGLSNGYAHVIENVNSFPSTFFEEIIAGMLDLSPEKWRKKKAQGFSVLRSKCDAMKTAWEPYDWTKRIDRSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ64</accession>
    <name>A0A0D8XZ64_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ64"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9793" checksum="293F96CD50AF01C8" modified="2015-05-27" version="1">MSIAFNHQNSSCVSKTFHKTLLTMVSQHPNQICRNTQGLGGPIGSTLSSLQSSAWYYLHLLYSLLYFFIEIFMNLRVSYVYVFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y062</accession>
    <name>A0A0D8Y062_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y062"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="21392" checksum="8D8C9DAE08441CC8" modified="2015-05-27" version="1">MIKTDDKLYVRRLHNRCTNVRGVGTLSTSESWMSNENTKYMVMLKRISEASATESLVKIEILEEGRGKTISNAVIRASSLRTHDAIELNFPTFYNNHSIKGNQLLTDLIALTNSDKLQAILVLLSDDDLCVSVKPYYLSADKLIGYDVSRQSHRNDTYAYQPQNSAEPHLSLVTASLGFRSGILSTTLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y162</accession>
    <name>A0A0D8Y162_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_03998</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y162"/>
    <dbReference type="STRING" id="29172.A0A0D8Y162"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2Q6</accession>
    <name>A0A0D8Y2Q6_DICVI</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="168" mass="19463" checksum="EB8F6FCD499399FE" modified="2015-05-27" version="1">MTTLAEKRSLALAKAQAFVRTRKVLKPMSSLSRLFSLSVSINCDKWYQTMDEKARLMLQDPPSLADGMDRDTEKDLRFFGCTLIQEGAVLLKLPQVAAATGQILFQRFYYLKSFLKFRYEHTVMACLLLASKIEEEPRRTRDVYNVFYRLEQLHKLRESGRAINDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716205">
        <property type="protein sequence ID" value="KJH50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y361"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19269" checksum="4E7CBA75D4948609" modified="2015-05-27" version="1">MTSLSNSLKTINDSTSIDLHHSLMQLEAFPMRNRNTSNSYHFIPKVAGSSKQLSVINLVSTFDSTGGTNVGQRMVRILSAAKSKSNIKFVTALHCDRFDELSKKIFLVPASIGGILLTFPLNWRKFAGQCYSEIENLTSYCTCHFHVPHRPLVFMTQRFVQKDKCAGVLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3A7</accession>
    <name>A0A0D8Y3A7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3A7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11115" checksum="B5EE5E6E14680A93" modified="2015-05-27" version="1">MYNNPGFHSNDFIAKMKKIGVKETNMLYEEGKGHGIVLLYNSEFNSLYLPSLKLISHPKKAKAAIMYNNPGFHSNDFIAKMKKIGVKETNMLYEEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3I6</accession>
    <name>A0A0D8Y3I6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3I6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3I6"/>
    <dbReference type="OrthoDB" id="5791810at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18411" checksum="757B30FA9E786F94" modified="2015-05-27" version="1">MGDSLDERITEIERILGIDEHSTYLIYWNIFVLCSNTVYICCIFNEIKVRATDFDVASLLEKMRALGLERVMKIPLYKFKKLKSVSTMPETRSLSERLLTIEFCESLIRQRAELLKEFEERLQVVLKTDKVSIAAEQEEQLDILQSDILKSLDDWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y406</accession>
    <name>A0A0D8Y406_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716199">
        <property type="protein sequence ID" value="KJH50719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y406"/>
    <dbReference type="STRING" id="29172.A0A0D8Y406"/>
    <dbReference type="OrthoDB" id="5862419at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="48494" checksum="BB9320691E71A664" modified="2015-05-27" version="1">MLCIFSGKSIEGGNRDMVGLPPLIPDWEDDKICHEYLDEYPYHLTDFAKMGYKTKNTLFIVNVPKNTLNIRMKFPTMVAQDYGPGVAYYPHCMGFNKSEADHIWRPFDLRIEESTIFRKSFEDSCSERHLEMLDYLQKFMNAYAGTPKIAQVWPTWLAHDTMKNLFHADEHFLKFFKKNRAQIDRSFFFFLGDHGPIREGIGKTRLGRYEGLNPFLMVLIPSVYRNTPIHFQLRQKTYELMTHFDIHATIVDILKIQPAAGYMDTSYRNLMPLSKGSSFLREWRGPRNCRTLPIPSHYCICDYEKTNVNQETLTEKLGWFFAEQFNKHLFNHGLSDKCQMQSFNSTASVRQIKDGLSTLYDIVVYLVPSGGLFSAHIRSNSSGLTLSSGFIRLDRYGRQGDCLVGNALRSLCHCKGTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y546</accession>
    <name>A0A0D8Y546_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">tRNA nucleotidyltransferase/poly(A) polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y546"/>
    <dbReference type="STRING" id="29172.A0A0D8Y546"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="11">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="12">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH49671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="577" mass="66917" checksum="74AC97C6B0AC03CB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5F2</accession>
    <name>A0A0D8Y5F2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_01856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5F2"/>
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    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AChE-related_enzymes"/>
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        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="20499" checksum="2C7D8562F8EFF9F5" modified="2015-05-27" version="1">MVGDYFFTCDSIWLANEIRRYDGHRGRVYIYYFDQPSSANPWPKWTGVMHGYEIEYVFGVPIYNETAGYTKREQILSEKIIQYWSSFASTGVPRLKDSKATDVWPEYDGFNNTRWMMLKGGSHLKPMNARKKVECDLWRQAKDIEYNSYVTELLHSSATRISLILSIFFVNACIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5F3</accession>
    <name>A0A0D8Y5F3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5F3"/>
    <dbReference type="OrthoDB" id="5856121at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20483" checksum="36290ED73335CF22" modified="2015-05-27" version="1">MNFHQLSKKYTLDKENMDCFSMLWKTRQSWNSVRWNKPSTTGYRSQSSSIAAQFESKSYRSTSPTAATSRHKNATSEAARTAAKLASLGPSVSARASYFDSSKHDNITNKYRNEARELLNKWTNHERNGSSNADPLTSCVKKAGVYLLNLIKKRLINGLNRFLWNTLRIQCNDSRYNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5H6</accession>
    <name>A0A0D8Y5H6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5H6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5H6"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="391" mass="43628" checksum="B157372C40B9242B" modified="2015-05-27" version="1">MMSSVTSRLMSLLKTHRAMISTAVSSDMIKFRSSVMNCSSAKLNRYGGRHNVTALPGDGIGPEMFHHVQKIFSYAQVPVDFEEVDVSSARDSHNDIEQALTAIRRNGVALKGNIQSKFDDPHFISRNVELRRELDLFANVLHCCSIPSVPCRHNNIDMIIIRENTEGEYSGLEHETIPGIVESLKIVTRAKIERISRFAFQYAKKYDRKKVTAIHKANIQKLGDGLFLKVCSEIAEKEYPEIKFESMIVDNACMQLVSRPQQFDIMLMPNLYGNIISNIACGLVGGPGLVSGMNIGDKYAVFESGTRSTGTLLIGKNIANPTAFIRASADMLRYLGLNVYADLISDSLYRTLVDRQIHTPDIGGSAKTSELVESVLDYIKQEIMEDNLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5S5</accession>
    <name>A0A0D8Y5S5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_03951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5S5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5S5"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="8">
        <location>
            <begin position="123"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="447" mass="50425" checksum="078856C7860598DC" modified="2015-05-27" version="1">MKRIIFPCNIILDAIKCLDYILLDEEDRDRFLRLALCCSAVICCRCTPIQKAAVTRLVKANVNGVVLAIGDGANDVAMLQINKYWDKYGEIFSDMQSDQKEADVGIGIAGQEGMQASLASDYTITQSIFTYFNGYSVQTIAYEWTVLLYNMFFTSFPALVMGAIDRPAPINSLIKYPQIYHYYQNSLSNMGQFRWCICGVVQAMIIFWVNYFNWGEGAPMHFGQDSSLWVFGIFVYWCLYISLFSTAIGGILFMVPLQSIFFVIILVVVAALVPDVAFKVLSESLAVRQSFVSAGQFHACTEKFRRMLRADMQDAMLWQEGFRGPNFNILYQPIFKMCDIVGLKTYGELENGFAFAQDDGLAVMQMDLLQRYSDDVDNTMSTALLESPKASKQNRISEIRTSKVPVKRELFAEAYSVVEGTKKVKALERSVDDKTVESTSMKSPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6B6</accession>
    <name>A0A0D8Y6B6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_01588</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6B6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6B6"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH52260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="23484" checksum="1380CD3296AB2AD1" modified="2015-05-27" version="1">MERCYCCGWLECGWKRRALVIKLLWSMHAQSHSSDINLYDKIDPKKLTMDSDLTRDFGLDSLDHVEVIMAMEDEFGFEIPDGDADRLKTPRDIFQYIADREDMAKALLYLPNWTTEQVIFTFISVFLVLFGIHRFLYEKLWGCQRSFRIAIQRKKRARSDGFAYFRGRVHTTDEGILSKYKEILSWSFLELRSWFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6B9</accession>
    <name>A0A0D8Y6B9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6B9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6B9"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15445" checksum="ADDCE28347F3C4C1" modified="2015-05-27" version="1">MASCCNEDLLLQINKARFEFLVVMLKSAGNVPRIELLEMGPSIDFKVDRTKIASDSLFKAACKKPKSLTAKRRKNMSEDVFGSQLARVHIGKQNIDAIQTRKVKALRKFSSATKIDPKGDVSSGWKKDGGNHYNGEAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6F4</accession>
    <name>A0A0D8Y6F4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6F4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6F4"/>
    <dbReference type="OrthoDB" id="25346at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="16534" checksum="633873533F118629" modified="2015-05-27" version="1">MYRNTMSHHLIDGDVIDYSVSQVVLCEFINAGVVIGGARKLQMTSDKAEQLYEAHRGKYFFRRIVRHMTSGPVIVMCVNGDVRRILGSSQLYPLPNDDEFVNVRQRYALSSVRNVAHTSDVEAASRELALFEPYPPPHLLLNEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Q9</accession>
    <name>A0A0D8Y6Q9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Expression of the protease correlates with blood-feeding and suggests a role for the protease in blood digestion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Q9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6Q9"/>
    <dbReference type="OrthoDB" id="10058785at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="301" mass="33696" checksum="1C80A70DDE07CC16" modified="2015-05-27" version="1">MELVDYVNNNQQLFEASYTDANELRKKLMKPHYDRRIGKPQLQENEEDTAGIPESFDARTHWPHCPSISLIRDQADCGSCWAFAVGESISDRVCIATDANKTAEFSVEDILTCCDECGFGCDGGFPDAAWEYFVSTGVVTGGLYGTKNACRPYEISPCGNHPNETFYRNCTGVSTPSCKTSCQKGYPVSYKDDKTRGRKSYNLANSVSAIQKDILKHGPLVATFSVYEDFMYYKKGIYRYTHGGYEGGHAVRILGWGVENNVKYWIIANSWNTDWGEDGFFRMVRGINDCGIEESVSAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6X7</accession>
    <name>A0A0D8Y6X7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein SYS1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6X7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6X7"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15898" checksum="42E18E6DFC02F082" modified="2015-05-27" version="1">MNSFRSSVWDPLLLLSQMICMQTVFYTTECVAFLVLSLFGFLPTLAHIFTLQVFRAMVVGQLLASLSCGIALKFVVQRAKQCLDFSCTIHVFHLVFVAVYNQAFPTQLPWWGVQIASVVICTLLGEFLCMRAESQDIRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y756</accession>
    <name>A0A0D8Y756_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y756"/>
    <dbReference type="STRING" id="29172.A0A0D8Y756"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="18974" checksum="4B0D966B0D55F07A" modified="2015-05-27" version="1">MVVVIASPPHSQPRCITSAHIGREMGRESRHVYVSGLPETISDDRINSFFSTYGRVHQIERTSEGVVVSFMDVRSAQKAHAGDHRLESGIPFRIAFHEPDLKNGIVATSSMSTTSNGNSSPKSMPDVSRKRTPSPRVKDVCRSALQRVNTNSGKRLARSEVHKRDQGYEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y764</accession>
    <name>A0A0D8Y764_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disintegrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y764"/>
    <dbReference type="STRING" id="29172.A0A0D8Y764"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF248">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN UNC-71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
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                <person name="Choi Y.J."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="455" mass="53540" checksum="68E1E46BD3BA8147" modified="2015-05-27" version="1">MQWSLPVSHMIENQTQCHTVHYLQNCSLGISSHDPDTVRTQVGQSVILPCTTYGSLEPTIEWFVQTFFNTFAITTLLDVNLFRWLYRPATFLGIFDPYLKEPVNTNLTCCTVLAGGALLLHDVNRSMIERYVCVARKDSHVAYKIFHFRLDYSNWYSLDLFNSVFWGGIAMAVLVCSFSFLLNITWILTRKSVLWWIQRAERLSRVRKMVEAMEKYRAWKMENLHEKYTRRLNLVRENYHAQVRYCIYVEQLRLSYSSQAEKFRDYRAAQMEHMSSHIENIRENYNQQMHRVREYGARRAEQLWESYERQVNRMKAFSLQHRLKLMRQYKVKQRYLNNLLESFQHAPNPEAMRRHEHEVRAALDLIDPAESPTDNHPLSRASSFYSLPEYIIDGNDELRPSPIIGKVRFTPKNVHGKGAAANHSLNKEFGTLSRNKGTNDFRAESKWDDPSSSKS</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
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        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH52777.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="28215" checksum="DDF7A19ED24CCBB4" modified="2015-05-27" version="1">MKSTVEERHRDFYLHITSESFQRIDALCDRPHGDTVKKQQNSCTSKPRTPVDKKHSEWTAEKQMEHEITRNKMKCLLRKKRKKILNDTPPVSQGSIDSKSATGFTSPDDSSKEKSDSSVSSAPEFIGITGNSMKTFFEPPETLIEMERRKKELLLPPSNMEELKALRDKKEALLKTVCKMCHAKLKVTEQQMPCACGYVFCKLHRRPDSHYCNIDHRQTGRRKINKENPKLVFGGIRKARMTPHS</sequence>
</entry>
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    <accession>A0A0D8Y9F6</accession>
    <name>A0A0D8Y9F6_DICVI</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="32825" checksum="6EF795CD8C2A60CF" modified="2015-05-27" version="1">MPVSSSISSFENLNLKCDGSIVLENQELKRQCDFMKGRISELEEQSENSNNSCEELKRVLRMKTAEAERLGVLCDEFDEIENDYKQQVSTLIKERDQLKEQLNSLFANGDRYQRAELREKDFDTSLIRSVGNLNLTSDKDKIFMENEELKRRCVILEERIIQFEKMSDEANKAGNTAQNEVYSSHKPVASRNNILSSASKTSFTSNTIDCGTSKDVCDNIEENMGPFPQEQFPASPNYSVGPTFDESIIEVAGTPNRTLRTTIYKGFEKSAKLTESPDTKMNNSRCSQQ</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF91">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="190" mass="21671" checksum="B2585079CC519D3C" modified="2015-05-27" version="1">MMERRETYTTHQPDGTYLTTTTRTQTKFHEDKVYGCGMGQMNKHYCFGPHGILRILEIFLCLVVISLITSVFGPGPFKGVLFGQTLLLIFAGVAMCFTFIFLVVYFFTLNETHLDFWPWRTTDLVFSATCCVSFIILAIVEAYYSTGSWSNNCNDIGSDGLIHNGCRLIYEWAFASETLNDFFSGKKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9W4</accession>
    <name>A0A0D8Y9W4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_00861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9W4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9W4"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="91"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="701"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="883"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119764" checksum="5016C1745E6FF4C8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAM6</accession>
    <name>A0A0D8YAM6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAM6"/>
    <dbReference type="OrthoDB" id="5836875at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="42096" checksum="181C97DF7876141D" modified="2015-05-27" version="1">MTEVTRCADRGDTVLFITNDGVVPVSKSLLGVYVTFDFEKYQMFRFGCLYPIRSRVFETLLGTLEISVHEFLVSLIVEALLRFRMSCNLVKGVVPSRIDVTSLPKNAVEVFLRYFVINEKINEEVSIRDVATLIYLAEFYSINNILRQISECMMQASISNERSLCLCYNLSFVCNLHIKTQLAKLVAIKFDKMRSMLCELIEDSECLLPILQREQCVRLLNCTRKSLISTIDMQSLSSYVLEIATETMNEAWKSFVNNSSSSICWNSKHIMEKWSRCGTRREADSSLKVSHRNQLKHVTIALPVNDGDDDVNDDVTEHHHKETSSKRKCENVHGRTTSSTISKVTRKNLFVRGLLKLRQKFTRKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB59</accession>
    <name>A0A0D8YB59_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_01977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
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        <property type="entry name" value="INTS3_N"/>
    </dbReference>
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        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336361" description="SOSS complex subunit A homolog" evidence="4">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="369" mass="42460" checksum="4E2D5A5A2E0C1CD9" modified="2015-05-27" version="1">MLGRELLLVLMRLAKITQIHSIWVDLINNPAKFGLNEGIEDLFRSNANFYGVRISPEMAKKLEFIICQCKANVQDKHFEWFSNTFFRGPDGPSLRAEAIRYVLYFFKPDMPTHVLEARGHLLYYLLTTVPQNSDVEQQWCKTAVWFDWLTYDAHTSVQFIEPVISMVRIALASVPTKATSLLEYVCKSIALIYPARTDLFKKAANDAMHAVHDYYGCGLMSILDNPRIERSVRDLLRETFSDYFARNVALPSAISQASPLVTLVPPQQPRHANTLVSNSNHTSTTKERVRVKNKDIDRDEKERIKRSKTPSPPNGTVFGELEETKKKKREEEIDDLIEQLRDDFKATMMSLRLVWFTSSPSRYLKYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBF8</accession>
    <name>A0A0D8YBF8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent metallopeptidase HflB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_00287</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBF8"/>
    <dbReference type="STRING" id="29172.A0A0D8YBF8"/>
    <dbReference type="MEROPS" id="M41.A10"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent metallopeptidase Hfl"/>
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        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="367"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH53542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="714" mass="79354" checksum="A48F02AF0CE77A7A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBQ6</accession>
    <name>A0A0D8YBQ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D8YBQ6"/>
    <dbReference type="STRING" id="29172.A0A0D8YBQ6"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11250" checksum="CEB60B28DAC1AC7B" modified="2015-05-27" version="1">MLSGEEVFKNPLESLEDESSNNTKAVTQALSTPVQSRCERSISAAVDVNTDGRTSPGTIANDNRFHRTEEINVDLDADDAISVDISDALSERDKKEVIPLFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDD6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_01216</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDD6"/>
    <dbReference type="STRING" id="29172.A0A0D8YDD6"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <location>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="335" mass="37335" checksum="F086B6D7E524DBC3" modified="2015-05-27" version="1">MINITSNEFKRLQGRHGDFENPIYDIRKCLPWQQTLSHCIPPVVHRKSSSMDSQVVAAHAHIHLHRKSSSMDSQVVAAHAHIHHVRRTATVSSTEQLDRNPDSVADSNLMHFHKLSVSSCPLSNSKSSVDLHMTLPAESYFTTTECPGLLQSRSSSSEADLNEKLPRCSSPQKDDTLNMTTEKMDIIQQPDKSRFDHQTTTNEVADSYTITEDEFIQPQSRRFEKRLVLYHTADGIDVLKPKGTVLQGGILKRFSWNVSSAVGASSRKISARLGEHNRRHSQTSTAASSESFGSSTSGISTSSSHTDKYENAYFNHSGKRRGLNGSFPEHQSQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDR8</accession>
    <name>A0A0D8YDR8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDR8"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="138" mass="16206" checksum="0E92DF138907B838" modified="2015-05-27" version="1">MCDFVKYGFSASSSTADMKSEEMQKSKSAIHEQNAKAYMHVLNSHKRLNFLHQAAVHLSFQSSDIDDGYAKLARRYTKLFRDVLKTERVRRCELTLVKRKIIQSKCILCGCIRNYEWNTDYLSRNQKYWANDHEAVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFW8</accession>
    <name>A0A0D8YFW8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000131">
        <property type="entry name" value="acidic leucine-rich nuclear phosphoprotein 32-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="25418" checksum="CCD72EE35F4C01DD" modified="2015-05-27" version="1">MEGRYVLELRDRDPATVEDLVLDGCESAEIEGINDKLVNLQSLSMVHVGLQNLKNMPKLPQLSKLDISDNSIAGGLEHVADNCPELLHLNLASNKISKIEDLEPLKKLKLAELDLFNNPVTVGGDGDYRSKIFEMIPSLQILDGADVNGEDVDDSLDGEDGAEEEDSGDESGSDIDGPGLSYLDNTQLDEDESEEYKPGDHIEEQEPKRGLKRRNEETNGEESEAKKKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X531</accession>
    <name>A0A0D8X531_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kringle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN722461">
        <property type="protein sequence ID" value="KJH39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X531"/>
    <dbReference type="OrthoDB" id="5917794at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="146" mass="17072" checksum="BCF0AF3FD4E7512D" modified="2015-05-27" version="1">MAPKKFPLKSFSNFSSPSMDYMTLNVYSTTISQHENYCRNPDNHKLGPWCFYKEENEIRRAPCFHTCVTDITHLCLAKAFFPFYQTPYSFDTVPLSPVDPRVLRSVDDTNLKKKNARLGHLMNIFSGTYLHFFKKNIVERYKSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X743</accession>
    <name>A0A0D8X743_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN717353">
        <property type="protein sequence ID" value="KJH40333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X743"/>
    <dbReference type="STRING" id="29172.A0A0D8X743"/>
    <dbReference type="OrthoDB" id="5912168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="25575" checksum="AE329763C971B033" modified="2015-05-27" version="1" fragment="single">AVEDNRYPWNVALIGPNTHCSGTIISKRHVLTAAHCLSTKIVTPQICSPKPLPTDDIYAYPGTFVYYTGDHVNGYPRHSLIKSTIHPDYKCNTHDSDLAIVEISPEIPATSVPICVPNDDEDVHEGENLTAVGFDIERREFGDKYQLKVVSLSISYVDALNSKLQVDSPGKGVCGSDSGGSLFRTTRVKSILLGITTFPTACETDPYHGRHTEFHDVRRYLEWICRISGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Q6</accession>
    <name>A0A0D8X7Q6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720257">
        <property type="protein sequence ID" value="KJH39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7Q6"/>
    <dbReference type="STRING" id="29172.A0A0D8X7Q6"/>
    <dbReference type="OrthoDB" id="10268034at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="16824" checksum="06C32FBD8F98AA66" modified="2015-05-27" version="1">MSTLTRNFRLPSGRRVVFTDTIGFLSDLPMQLFAAFQATLAHVKLADVIIHIRDLSNPDWSAQSEDVYKTLKAIGLSEKRISDIIVADNKVDVCDAPLVPTSNAIRISCKTSEGVQTLIQRIDELVLRASGCKRRKLELKFSSPAVAYLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7S0</accession>
    <name>A0A0D8X7S0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_13448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717096">
        <property type="protein sequence ID" value="KJH40593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7S0"/>
    <dbReference type="STRING" id="29172.A0A0D8X7S0"/>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF242">
        <property type="entry name" value="DEGENERIN UNC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 13" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="11 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH40593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="34490" checksum="F83BA979BB054A5A" modified="2015-05-27" version="1">MDRDFKLHVDPEYGNCYTFNFNDSVELKNSRAGPMYGLRLLLDVHQDDYMPTTEAAGVRIVVHEQDQEPFPDTFGYSAPTGFVSSFGLKTKVLHRMDAPYGSCSDTFRPERYIYNEHYSPEGCHRSCFQLKVLDECGCGDPRFPLPSDEKRYCSAKSVTDRQCLSNLTTAAGGYHHLQLECDCRQPCTENVFETAYSAAAWPSVNFKIGVDCPAVLNIFNDSEACTEYYRVNTAYIEIYYEQLNFETLKETAGYTMVNLFSDFGGNIGLWIGFSVITICEIIELIFEIGYYLLYIKPLRYVQ</sequence>
</entry>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717064">
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="21175" checksum="CE14763A553C5CD7" modified="2015-05-27" version="1">MFTFSINKSIIVPLESKYERGRWNCFDYYDKEPSTHAKPRVVDSAVLQQTVSNQESNRIARKAPHEKLQKGLENSFAPSEIRNLIYSKRPDLLNPSNASGANGTGQASTLAIDSKIEQAMDLVKTHLMFAVREELDVLRGKITELEAHVCSAMRVLVSSFFFFFNSHYCFIRFSIKKIFYGDMKH</sequence>
</entry>
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    <accession>A0A0D8X845</accession>
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    <protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720174">
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            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="12179" checksum="B4922997E30CB395" modified="2015-05-27" version="1">MEKPEMEIPESTTISAVDFKTSFATTSSDDFLHREQRSLENEGIIHTHSTSQCVLTPSEQTFSNGNVASECSGKTKGRERRGRRSSLKSTSQPSVSLTDVKDEQTVRAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X856</accession>
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717031">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="22108" checksum="1AB5AE9051BBE2E3" modified="2015-05-27" version="1" fragment="single">MFEGAHGSVHMGSNGVRIPTFYVDGLNGFGKQELYGTVIVENQNGVSLIYEPLYTNETLLWWSRGGIRPLDEPLCGFSGKQCPIRFFEENLAWIIPGIVSMALIIFLRRKQIDYLNSLWQIPFTALESISSEKNKESRRSLQSGTSSALNKVDVENLSQKKNYQFYTYQGECLAAMKHEIMPRLTALDFNEIRQ</sequence>
</entry>
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    <accession>A0A0D8X8D8</accession>
    <name>A0A0D8X8D8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thrombospondin type 1 domain protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">DICVIV_13208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717000">
        <property type="protein sequence ID" value="KJH40830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X8D8"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000128">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs adt-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Adt-1/2-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="411" mass="45679" checksum="6E721814C93BB3DD" modified="2015-05-27" version="1">MMEMPRWYVFCDVANRPGGQRNYRFFGDNLPDGTPCGYDRYCLDGECLPLSCSNSALIGRDLQCPSEVCPFENKMILKGEWGQWSLWTACTVTCGGGHRKRSRACSIKGRCEGAETETEQCITAVCPLVGAVGNSQWTTWTDWNHCSVSCGRGSQARYRKCINVQHSLAFDCPGELKDSQNDDIRHTFYRDTNIEVRACDAGPCTGIGVWAAWSEWSTCSASCGPGTVTRQRGCHKEPCDGFAHERRSCNKGMCPSLNGQWAEWREWSECSRLCGRGIRSRSRSCLGSGCYGVDGEQTFCNEHPCEARAGEWAAWSTWSQCSATCGAGVKRRSRYCRSGSCPGNYKESAICNDRECESRNAAWGGWGYWSTCSETCGEGTRKRVRKCYGSGQCGGNDFEKQPCFMRACNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8H7</accession>
    <name>A0A0D8X8H7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor 1-like 2</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_13996</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. Plays a role in maintaining mitochondrial morphology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KN717996">
        <property type="protein sequence ID" value="KJH40082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8H7"/>
    <dbReference type="STRING" id="29172.A0A0D8X8H7"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH40082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="22965" checksum="AE7F0F78B7B14EB7" modified="2015-05-27" version="1">MQISSGLLLRRQGVVVCYRSVLMGNIFGNLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVGEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEVTDKLGLHTLRNRSWYIQATCATSGDGLYEGLDWLSNQLKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8W5</accession>
    <name>A0A0D8X8W5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717626">
        <property type="protein sequence ID" value="KJH40182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8W5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7695" checksum="5A3E747C56D983DD" modified="2015-05-27" version="1">MLICITLIAGVTALIEDRRCTVPVLGTLQFAKTAANCEDKLSDDKCKMFYPKGIAVGSKDERPTKCFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9D6</accession>
    <name>A0A0D8X9D6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716883">
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    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6285" checksum="ED1F9FADAE1C4A13" modified="2015-05-27" version="1">MTKCSACDTTLHLPAVHFLCRHSYHVHCFESYSENPDVCPACIQSAISQFATSASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9L8</accession>
    <name>A0A0D8X9L8_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716867">
        <property type="protein sequence ID" value="KJH41253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X9L8"/>
    <dbReference type="OrthoDB" id="5872352at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="23141" checksum="258EBD22DB7BA1D5" modified="2015-05-27" version="1">MVLQDNNINLSIDPKIESIQPQILLGCSDLFDLLKDERAKNKRLPSELRLIFSKSGYLIAGCNRKRRIMSENNIILAGEITPIPQETAKHQSWDEFRTFESSGVQEFSGSNAEERRQQNAANWEQFEKTIQKREDGYYVRLPWKENANTLPPNKGMAIQRLQSTINKLTTNPILIQQYHETIIQQLNRGIIEEMLANNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA83</accession>
    <name>A0A0D8XA83_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Forkhead box protein fkh-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Forkhead transcription factor family member fkh-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717132">
        <property type="protein sequence ID" value="KJH40544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XA83"/>
    <dbReference type="OrthoDB" id="6230630at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20021">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR46617">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
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        </location>
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            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="25841" checksum="1F01FA12CA1DE212" modified="2015-05-27" version="1">MAKFSILDLCPDLVEESSAASSIKEEVHPLSPIMSDITINQVDDDLADEGIEEGPSESSDSNKEYSKSPETSSEDVEKKFGPNDKPPFSYNALIMMAIKNSSEKRLTLSGIYDYIMTNYPFYRDNKQGWQNSIRHNLSLNKCFVKVPRSFDDPGKGNYWMLDASCEDEVFIGGATGKLRRRPSTMSRARMDAFKQYGTAAAALFPSYSPVSDEIEIVYFPSKSKQKDVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAA6</accession>
    <name>A0A0D8XAA6_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716809">
        <property type="protein sequence ID" value="KJH41508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XAA6"/>
    <dbReference type="OrthoDB" id="10260567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="3">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46934" checksum="FAA34E66DE55DFEE" modified="2015-05-27" version="1">MELNTSCNRLATIDTSNILRFFDLHKDNISKVASMDVKEVADFKWDEEQDDSIAYLSKQKLFVLRGKETEEGISCEGYICSFRGLVVRTVLLDSFLLPNSTPDRRFLIDSEIKSLRNAKVMLERLKMEEAVQFIEKNPHPRLWSLLSEVALLRMDITTAEYAFVKMHDYCGLRFCKKIMEIQDLNYKKAEVFIHLGRVNDAEKLLIEQDRRDLAIDMHKKCDEWSRVLRLVSISSNATDDKQKIEALKNVADYHRDRQRWKEAADHYELAGNLDQLMICYIHLDDFYGLENLAKKLPDYDILLTQIADLFASSGLCENAVQCFLRCGQIAESLDTCVQLNNWDKAVALSRTHNLRDVDVLVGKYVKELNESSERSLAAVQLYRRAGRFLDGVRIVYMVTLFLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB25</accession>
    <name>A0A0D8XB25_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_13057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716945">
        <property type="protein sequence ID" value="KJH40977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB25"/>
    <dbReference type="STRING" id="29172.A0A0D8XB25"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9716" checksum="BD845A947BD68289" modified="2015-05-27" version="1">MAAQTATDTDLKTFRDFLMQYNTVTEQCFGACINDLTSRNINEKEERCSTNCLDKYLKMTQRISLRFQEHQLLSAEAQGGTAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBF2</accession>
    <name>A0A0D8XBF2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KN720546">
        <property type="protein sequence ID" value="KJH39791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBF2"/>
    <dbReference type="STRING" id="29172.A0A0D8XBF2"/>
    <dbReference type="OrthoDB" id="5826103at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF194">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="125" mass="14508" checksum="D823027E05BCFDEC" modified="2015-05-27" version="1">MNRLFDLIGRVPQEKFLFLGDYVDRGPQGVEVQLLSYPLLLLCRSETVTDAVIILLFALKLRYRDRIFLLRGNHETPAVNKIYGFYNECVMKYGPGMWWDFQACFNRIPLAGLISKKVCALEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBK9</accession>
    <name>A0A0D8XBK9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase activation peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716730">
        <property type="protein sequence ID" value="KJH41968.1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="13469" checksum="9434C4F6FA9495F8" modified="2015-05-27" version="1">MLTNKRPQTFPYNTSLYSFLVCILFFDAANAEKYILYHVQPNDSRGMHELRKLQMLDHKYQVDFWKEPSHFGDFADIMISSKHASAMEQRFRRANITYDIRVPDVEKFAIASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBM9</accession>
    <name>A0A0D8XBM9_DICVI</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716727">
        <property type="protein sequence ID" value="KJH41988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBM9"/>
    <dbReference type="OrthoDB" id="5869888at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9800" checksum="A9AEF73582CBDDF5" modified="2015-05-27" version="1">MMANHAGDIVVVHLTKALWKEFRDRHWHDFEEFEEIKDQRTLCRHLKSSMIVDSSSSKQKPRVVTIVNSGGNVMSDSMNSEKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBU1</accession>
    <name>A0A0D8XBU1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716880">
        <property type="protein sequence ID" value="KJH41202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cortical cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
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        <property type="entry name" value="F-actin capping protein, beta subunit"/>
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        <property type="entry name" value="CapZ_alpha"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="32970" checksum="3D7C2ECCC61DC40B" modified="2015-05-27" version="1">MTSEATIPDSEKVRIVSDFLQHAPPGEFNEVFNAVRMLLNNDQLLKEGCAHAITKYNESQFSPVKLDGIERQTLVTPFNEIGGGRYVDDASKKSFKYDHLRKEASDIQPYPTELGLVESWRVALQNELDIYIDEHYSKSGIGCVFVRNGIFTLCIESHQFQPKNFCNGRWRSEWKIPVGDGKVGSQELVGKVKVQVHYYEDGNVQLFSEKDFNVNIHITSDVDKTAKDIMQSIRDEEGRYQQAVQENYASMSDNTFKALRRQLPVIRAKMDWHKVQSYRIGQEIKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCA1</accession>
    <name>A0A0D8XCA1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716861">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
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        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="813"/>
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            <end position="244"/>
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        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="2098" mass="233866" checksum="2FCD5A263EF9F885" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCM3</accession>
    <name>A0A0D8XCM3_DICVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="436" mass="49367" checksum="881771AC8F7F0AA2" modified="2015-05-27" version="1">MHWKTTTILLCIYGVVKEFRPATPFLTPYLISSSKNLTLDEVYSRVFPFWTYSYMVFLIPVFFLTDILRYKPVIVLEGACLSLTWILLVWGKGILEMQLMQIIFGIASAAEIAYYSYVYAVVDEEKYRRVSSYVRSATLTGKLLAYGLAQVLISTGTSSYLTLNQISLVAVIFVFFIALVLPPVTCRRVQKQTDIVELSGNCLFERRSMEQESICDGCREIPKWSIRRYFVSMLGNFAVFKDNPIVLKWSTWWALTSCGIFQVYNYIQSLWLEMQPDPNKVENGLVEVIGTSFGAMLSFIIQFADIDWIRFGDIILAIYSGTAAILLALISQTVHVLLAYSGYICVTAVYNMLITVASCNIAEQLNSINSGLVFGWNTFVAVVLQTSLTLLVVDSHGLNFNIRMQFVVYASYFSLIAVLYFTLSVYAGLKHIKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD19</accession>
    <name>A0A0D8XD19_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717384">
        <property type="protein sequence ID" value="KJH40311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD19"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15386" checksum="D7C7834B949E2A7A" modified="2015-05-27" version="1">MLTGQKLLSAVFSESTHLDAFSEIFYYQFLKSRGKGHHDMVDDNDYSGYGIGLCAQKLLKRFDDMMTRVGSGTITGIPLAPNEQVLRAVCKWYGSVMFWPDLLTSELYDFLSAKLHVGFWKEKRLEQHNRLCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD47</accession>
    <name>A0A0D8XD47_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716651">
        <property type="protein sequence ID" value="KJH42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="154" mass="18077" checksum="D939D3F1A0D2CBDC" modified="2015-05-27" version="1">MLVAVSWVSFWLDKDSVPARVTLGVTTLLTMTTQASGVNAKLPPVSYTKAIDIWIGVCLAFIFGALLEFALVNWAARQDMFPYQGRSRQPQKYMFFQNENLRQPEGYQFFAAVEPEVADIEEITYNWWEKLWKVKYRYWWRYLTPYLAVQAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDD3</accession>
    <name>A0A0D8XDD3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716643">
        <property type="protein sequence ID" value="KJH42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDD3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11371" checksum="55EEA0661A983318" modified="2015-05-27" version="1">MDERGPNEKVAEVRTLREDQSFIQVFNYVMDCVMTTLRVIRRTSTEAKEKSPRRLDNRSSSQQGQSPQFRCCVAVRNSKSSAHLFLELTWPLSRKGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDK5</accession>
    <name>A0A0D8XDK5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717141">
        <property type="protein sequence ID" value="KJH40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDK5"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="20574" checksum="1A095A65BD54911F" modified="2015-05-27" version="1">MVYYRADICVFNVTGCIAWYGAEIGDLYRVVFGSDSFGNTCGRDNGPIWIRSCNNEPRKKSSSKNSSFSAVDMDLIRGYMHDIRDISAYLLQTCFVALSKCTQILYLIPVFLKSKDVDFDNLLNCENISTLTSWAIGLGALAVPIFSISTLWCVWPRGKKMVRLFKGASLVNPGKFPLLKQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE56</accession>
    <name>A0A0D8XE56_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WDR19 WD40 repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716734">
        <property type="protein sequence ID" value="KJH41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE56"/>
    <dbReference type="STRING" id="29172.A0A0D8XE56"/>
    <dbReference type="OrthoDB" id="5846867at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="271" mass="30710" checksum="2678606E36B20AEA" modified="2015-05-27" version="1">MIAVGPYHVAVATNNRVWMYDVLHSGKKQPVAETEYLSTVVDVKLNDEFVCVVMEGKARLHKILNSDSHPSLTFPEPSRKTRLLAAALSKNFLIFSTEANYLVFFSLSEWCVVSEYRHTSPIRQIYPDQDGLRIVLFDERADSWVYSPVDDCMHKLPTIGSAVHYKAALWETFTIDRDTFVVYDNANLYVYLLNRNHIEGEAVLYVGSTKLPFLHIPLMLNKGIVHCLTSSAKTSGVLLDSHRTDTVLEGKTPAAVRMYLVIRFILIVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEC6</accession>
    <name>A0A0D8XEC6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716603">
        <property type="protein sequence ID" value="KJH43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEC6"/>
    <dbReference type="STRING" id="29172.A0A0D8XEC6"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF16">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="244"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="572" mass="67049" checksum="0BA7D9A0CDCC903D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFG8</accession>
    <name>A0A0D8XFG8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716663">
        <property type="protein sequence ID" value="KJH42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFG8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24916" checksum="1A649A438FF9F7C1" modified="2015-05-27" version="1">MPIDRQDIYDGLTRFLVRNSSSLETLVNLTHDFRDAEEIRAQINNLRSALGRENVAATLQLTVTPTTTYLYFMEKDLNAVNENSFDEVANAAENELDVEGPENLPPLDDDISMTMTIRVEVKDPDAALRSELEFSEPSIIEISLCFKANNPYVKKKVVNDDNNLIFIVCSSTRKLEDKGTVNTLINGHRAVVVMATFSPAELQRLECPGIKYSMDNKAIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG06</accession>
    <name>A0A0D8XG06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonate dehydratase, eukaryotic-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716857">
        <property type="protein sequence ID" value="KJH41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG06"/>
    <dbReference type="STRING" id="29172.A0A0D8XG06"/>
    <dbReference type="OrthoDB" id="5978072at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CA_dom"/>
    </dbReference>
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        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335601" evidence="2">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34512" checksum="27F628EA13B789F8" modified="2015-05-27" version="1">MLPWLMTACIYPCVVGPDFWGLVNRDWRMCTAGQMQSPVNIDPTQLLFDPHLGRISIDDIQITMHFGQPDGEKGSEHTVDRVRFPAEVQLLAYNIDLYTNYSQAMTQPRGLLAISVIVDIGDTTEVVLRRLTVASQSITYKGMKTVLRQLHPAGLLPRTNHYVTYEGSLTIPGCHETVTWIIMNNPIYITREDLQIWNELQKTETKQPDPAYMTPAYRPLKALNGRLLRTNINLTYKQISSSSSSCSSNVFTDMGYRSNPLRTHHNQSITRRSTSIRVEQQNVFRLEHIKSGMHSNFDVIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHK1</accession>
    <name>A0A0D8XHK1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716581">
        <property type="protein sequence ID" value="KJH43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHK1"/>
    <dbReference type="STRING" id="29172.A0A0D8XHK1"/>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.120">
        <property type="entry name" value="Proteasome activator pa28, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036996">
        <property type="entry name" value="PA28_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003185">
        <property type="entry name" value="Proteasome_activ_PA28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02251">
        <property type="entry name" value="PA28_N"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00037467"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
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        </source>
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            <dbReference type="Pfam" id="PF16565"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="641" mass="73401" checksum="B04018B858436C40" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="KJH44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="227" mass="26190" checksum="A8D13067CF16E2B5" modified="2015-05-27" version="1">MRQSNSFNYKIQFDCKGFGIHDMALINRHHESDGGIFYAKYRYMGDVQVIPAQNIFLNRDLRDDSFSLHNLGVNEAIDVFRILFIKDYDDPFYLRLLENMVQIDDVDTIERTQTAISDTVKTQGSNSQAEREMKMMENLDLFTRDLKEKPKTIAKTTEITIDKKSEIEESNGKKSEHEGMNVDDSTQRSTVEKETKKSTTKSSQRKEGKVTSDTIKTEGTISAEYDR</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="46258" checksum="5747F03138150D95" modified="2015-05-27" version="1">MHKLYVVAMLLSKTVAFPMLPYIQLDYAHYFRLAQCQAMCTERCESGCHQHRRLYARGSRNLSQNSPMNDGLRFWAASSTGSAKTGSNVMSTVQLLCQNSVVDEEFGESVEGFVSISLIRPVRPIRFVIQWKQRTDMIGHFEDSQWITASVEHDSLFKVRGLIPGIQYRFMVTAVSVNGKLGDTVTSDWTEVSNGVMPKPPANSLTLSNGYNSNRGVMAQLQWTRTFFDSCYYKLQLSNGSYQVTTDITLDSSPSILLPHLQFDTNYLVTIAAVSADKTQTSKSITTHFRSLQCRDVHGHGSLQCLPEPVTDLTIVVRPNGTGLVSWNPSTDPQNILFYQLIYFAVTQNDGCQIRKQIFNVKATVTSTEVIFPGNQCEYLVRLINYDLLGRDASAEVSEKQNKFSDYAKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK65</accession>
    <name>A0A0D8XK65_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sigma non-opioid intracellular receptor 1</fullName>
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        <alternativeName>
            <fullName evidence="10">Sigma 1-type opioid receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
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        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ERG2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
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        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH44980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="25193" checksum="E06C3A6A48B4ED15" modified="2015-05-27" version="1">MGFLFSKLIRNIVIAYVIFSGIQYILRWKSYVISPKEFRTIASKAQGVDNVASAVSRLTTDLRRTYGPAIAVDVPWVALSLGGLPLKALFLHASITEYVGVFGTPFPITGRIGMHWSNSTCTVLTGSVTRLSDLGHIPNKETFSAGGNFRHGQFESHIYTMGADTYVVCYGRGVIPISGLCAAVGAISHGEPLSLVRVIYTYGHEAFNQLSLTMMNIVNHYKSKATGKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL11</accession>
    <name>A0A0D8XL11_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 1 TTP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL11"/>
    <dbReference type="STRING" id="29172.A0A0D8XL11"/>
    <dbReference type="OrthoDB" id="5863468at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="2">
        <location>
            <begin position="286"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="585" mass="63781" checksum="EEB65DDC05A7D2C1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL13</accession>
    <name>A0A0D8XL13_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716469">
        <property type="protein sequence ID" value="KJH44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL13"/>
    <dbReference type="STRING" id="29172.A0A0D8XL13"/>
    <dbReference type="OrthoDB" id="5808636at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="249" mass="29099" checksum="1D57EFBC69BF05F7" modified="2015-05-27" version="1">MMPNDDDDEEEGVDQVILTDVDGESRSISFPGCYRAKVSFRMKKPIINPYIEAFLQLGQNIPCRSDRRTFVSNICTNITQTNWCPQSQNSQLRRMLIDKETCQFCHICDTVKGETHKDKSDWNRYIIAGGSEECDLTRDRQTFQFKMCSPSRAELNDQNNEERNKLEEYWNYLKQGVLTAVVHVMDRSELTTQRRQQCQKMCKTYSNRRGISQNYRTTLLKSIESLCTPFDEYAACVYHTVKFDINTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM94</accession>
    <name>A0A0D8XM94_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716553">
        <property type="protein sequence ID" value="KJH43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM94"/>
    <dbReference type="STRING" id="29172.A0A0D8XM94"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="8">
        <location>
            <begin position="457"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="652" mass="73682" checksum="7B38A58D1CCA89D4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMI1</accession>
    <name>A0A0D8XMI1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="4">HannoverDv2000</strain>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
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            <begin position="52"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH45965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15224" checksum="4ACE5000108E0289" modified="2015-05-27" version="1">MRSLLRTVQIRTDGNIYPFLKTIRYRDLPTPMDKGVPLWFTLFFVMDKGVPLWFTLFFCGLAMLVIVLCLVGWMCSMIKSSNRDTLKEMSIISLISKGYRHGNVIQSEKETLSELESATMTICTSDTRILASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNB5</accession>
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    <organism evidence="1 2">
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716417">
        <property type="protein sequence ID" value="KJH45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNB5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="96" mass="11008" checksum="512CD7D55276B6E5" modified="2015-05-27" version="1">MGYIFNFTALNKCREVSEGVDETGSTTSVAILHTALHSRPLNQPIRVKYCQHKSSVLFISIFNVIQQTTFTNCFVTNHMHFFDIPFVWDPMVHITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNQ5</accession>
    <name>A0A0D8XNQ5_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Peptidase M1 membrane alanine aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716411">
        <property type="protein sequence ID" value="KJH45372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XNQ5"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF21">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="145" mass="17015" checksum="8DA7EB11192FD270" modified="2015-05-27" version="1">MLQSTLDHPALVRPLTTELEVERSYHETYLHTKGSVMVIMIRELVSEFQFHSGMRRYLRKNAYRSVSRHELWESMPAYADHGADREQLSTVMERWLMNEGIPEVSIVQQLNYGFQPKLPKWHDLGNAAEQHEVRQPKRESIPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP01</accession>
    <name>A0A0D8XP01_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase, S54 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716402">
        <property type="protein sequence ID" value="KJH45529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP01"/>
    <dbReference type="STRING" id="29172.A0A0D8XP01"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="97"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23207" checksum="8BAB13A0E8BFFF4A" modified="2015-05-27" version="1">MTSRKAQSSRMRRILYLIADQVITPTQRIEIHSYLDEYTCCPPPFFILFISIIETTPSAWKYSGPNSNRCASRNRSQAMAHCPSLSDGGSLRSSGKGSLLQYTLDPKVYIVGASAGVYALLTAHLANVAINWAEMPFRYIRLTLIVIFLTFDITTAIIRRFCVDECETVSHSAHIAGGITGFCFGVLILYNVVVIFSKLLFTHKEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP15</accession>
    <name>A0A0D8XP15_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Disintegrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_09843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP15"/>
    <dbReference type="STRING" id="29172.A0A0D8XP15"/>
    <dbReference type="MEROPS" id="M12.A49"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADAM_Cys-rich"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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    </reference>
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    <sequence length="71" mass="8178" checksum="811B908FF5B548B7" modified="2015-05-27" version="1">MYTKPWCIKSSGVYRNGRPFQMAVCRTESQNLSLVPRHPLILVPLSNVKITTMSSSMNLSGEYRYLVRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716338">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="22689" checksum="CDDCD38DB91E0249" modified="2015-05-27" version="1">MGHGQSHRHPEEDSRVVNTKYGQILGRRFTFDKRQKPEPPEPWENVRETKKFAPRSIQKDMFIIEKTLGGYSQSEDCLYLNVFAPVWSPQSSTGFAVLVFIHGGGFVSDSTVKYGDVGICEHLCTKEVIVVTVQYRVGYLGFFSTGDEHCYGNFALWDQTLALKWIQDNISFFNGDPTNVTVMGQSAGGASVDLLSICPHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQY8</accession>
    <name>A0A0D8XQY8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoinositide-specific phospholipase C, efhand-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716327">
        <property type="protein sequence ID" value="KJH46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQY8"/>
    <dbReference type="STRING" id="29172.A0A0D8XQY8"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF196">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="359" mass="41830" checksum="7A27B9D16EF98E38" modified="2015-05-27" version="1">MATEDGGELESSQRRLDLPFADREMLRSSLIKHVNREKSPYRKTVSFSSRKSDRTISNVSDCWHHMQNGCEFIKLRGQGRHFRRFFSLDDNLSYIRWTPTNKKPHKAKISIDDIREIRLGKNTELLRQNETNSIDIQEECLFSIVYGNEYDTLNLLANSGEDANIWVTGLMALTSTKYDCRPSSTAWSTIRERWLGTVFDDEDPDRLGFIDQNTAVHLIQRTNPNLSLGRIRNRIKEIACVFDEASRGKISRDEFIDLYKEISTRPEIYFLMVRYSNKDYLSCEDLRIFLETEQGMVGVTTQFCEGIVEQFEPIPEARENNFMSVDGSNFTYHCFLKLSILISISYYRESTSLFFVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRG8</accession>
    <name>A0A0D8XRG8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_07584</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KN716357">
        <property type="protein sequence ID" value="KJH46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRG8"/>
    <dbReference type="STRING" id="29172.A0A0D8XRG8"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000721">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="433"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="672" mass="76416" checksum="9EBCB3D575FECA2C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRV5</accession>
    <name>A0A0D8XRV5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_08847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRV5"/>
    <dbReference type="STRING" id="29172.A0A0D8XRV5"/>
    <dbReference type="OrthoDB" id="8020218at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
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        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="208"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH45121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="36218" checksum="7DE4DADC5FC31845" modified="2015-05-27" version="1">MFGKKWPSIRLGLLTPGKYIAVLNTFSKDCDRHDELLQHMNTVDLLKCICGRTAFERIRKKREQIDTNAQKMTELVSKRLEIVLPELPLECNEKPIMRSEAGLGEFQHPSYTCTIGDLHMNKSQREDLENFQVTGFESEGLQMARRDHFLCYPSELRLRSFPRGVFCSYPPPFKDQNGIPSWWLLDGGSLVPVLALGLEKGESLLDLCAAPGGKSLLSLLTKLPSKVVCNDFKLARLGMLKRALSTYVPIDSPVSDIVILKRSDASNLATWDEINVYDKVLADVPCSTDRLAVTQDEGNMFSPKMTNERLNLPQIQTKILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSD2</accession>
    <name>A0A0D8XSD2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716417">
        <property type="protein sequence ID" value="KJH45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="11498" checksum="25ABCB7148C08F65" modified="2015-05-27" version="1">MIWEIFSFGQLPFYKHQNDSLRLLIVRKKAVLPTCLSHIPSDINELRIRCMDPDPEKRPDFFQIEDIISKMDGVIKPQSPSIFSKVFTLISDYISGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSG9</accession>
    <name>A0A0D8XSG9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 65</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716305">
        <property type="protein sequence ID" value="KJH47480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33226" checksum="CB2477537B0BE610" modified="2015-05-27" version="1">MITSKPCHCIQDTSCTQNIWKSPIQYNQFIHMELQLDYYNVYFLQHKGIQYMRLLATAGRLASRISVTGGCESVAVEPVVHRRFSTGAWQVVKRTTTTGAFHSLEKPIIEDHEEAIKIATRLTSEEQTLLRDALEELAAYNGVDALPMTAAQTRALFIVNTLPFIGFGFLDNMIMIVAGQYIDQKLGTLLCLSTMAAAALGNLISDVAGIGLAHYVESVFSKLGVKHPVLSSEQLSSTRARLTTNGARAVGLSIGCIIGMFPLLFYKNDRDNDSEIQSKDSTHHAERKYVILPFEPDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XST7</accession>
    <name>A0A0D8XST7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XST7"/>
    <dbReference type="STRING" id="29172.A0A0D8XST7"/>
    <dbReference type="OrthoDB" id="5863201at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="73"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="180"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="524" mass="59936" checksum="370D3CCB92A13324" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTC1</accession>
    <name>A0A0D8XTC1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable oligoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTC1"/>
    <dbReference type="STRING" id="29172.A0A0D8XTC1"/>
    <dbReference type="OrthoDB" id="5785168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF57">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE TRANSCRIPTION FACTOR MYB_SANT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="6">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="6">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072681"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="513" mass="60614" checksum="37B2ACC2D6EE50A5" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8XU07</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20361" checksum="6BDF2DB2A49756D9" modified="2015-05-27" version="1">MLRLDINVRTEEVTAVSLGLGNKIKKGQSPLELTQFDFDVTFDDDSQNAIIGKDIFLTEPYTCSNQCNCKRSPLRSCQRNPKESINDTLQISAEMVLRLQESVSMDSVLNTYVDPTFVDHDFPLISQSASWDDVFFSPPSITGNHFIKEIFINDRHSLKSDSVENEPPKIVEPRQKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVK8</accession>
    <name>A0A0D8XVK8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVK8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:coenzyme A biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="120" mass="13174" checksum="89FB15127D7B873E" modified="2015-05-27" version="1">MVIVGLTGGIATGKSSVAEMLRIRGMHIVDADLIARKVVEPGRPTYTKLFAELGDEFFDAQNGILNRSKLAIKMASRRIRSVVNLVKPLQSGTFGVVEEIIINMQIEIKSMILVHYAASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVM7</accession>
    <name>A0A0D8XVM7_DICVI</name>
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            <fullName evidence="3">Bystin</fullName>
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        <name evidence="3" type="ORF">DICVIV_06067</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
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    <dbReference type="EMBL" id="KN716290">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="751" mass="86523" checksum="9B9D6F2EEA0CB503" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVP4</accession>
    <name>A0A0D8XVP4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XVP4"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
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        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="416"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="497" mass="54425" checksum="7ACD174CC2F671E0" modified="2015-05-27" version="1">MLRLKILHCEAVTNLRSNFVISLLQCFERRIDAEFCTFFIEAYLAKVKLAVIRAFNLDVHAPIYKYGEKDTYFGYTVAEHFKGDEPVVLVGAPRAQSGQVGTNQAGALFACPINTNYYGNGSDWCQLVRAEYENESFYLKSPDSTLTAREVHYLGKNGELLGASLASQGTQKGGALVCAPLMRFHNTSAYTQGVCYELNNDLSLGGTYTTCLQKNLPKLERHNEYGACMEGFSAAYSGNTLVTGLIGAMKWTGGVYARRTEGGIFGTTIEKYTMASEEGSVRSLLAAHDYLGYSVDVGRFGYEKGERITVVSGATRFGQHGAVIFMPFTEERGDLLTFNEDKFLLNGTKMGSAFGYAIEVVDLNNDGFDDLIVGAPFEHRSDAEGHFGGIVYVYYSQGKERNKIYVSQGESLKVFHTPLILKAPGLFSQFGLSITSIGNMDGDKNGFNDFAVGAPFANNGEGAVYIYLGQKSKTDFKKAAAQISPCNHYISIAPYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVT8</accession>
    <name>A0A0D8XVT8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716261">
        <property type="protein sequence ID" value="KJH48630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVT8"/>
    <dbReference type="OrthoDB" id="5872878at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="31637" checksum="429D4114FC43D1B3" modified="2015-05-27" version="1">MARSDNRNNSRRRRSSEITECNISPKLDELQTDILSEALDQLSAVELRGFDSKVETEEEYMKRREEIRRQQTNPDDFDMNGRTELNYDDAAVAGAKLLIDETRATRSICKKLLEDCGINEDEILYKPLAYNEGTEYQSAKNLGDSRQASVVESFVDFKKQIKLKSEVLNCVAMKNFDGTSKSDGRLTRRAIEKARERRKSKAAKYKKRIMRTPCKNPQLNPLDEKKIIERYALEVASEVHENKKRRRIAPVPFDITLLDDIDYDFSGYCKASKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVV6</accession>
    <name>A0A0D8XVV6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative serine--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_05972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716287">
        <property type="protein sequence ID" value="KJH47952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVV6"/>
    <dbReference type="STRING" id="29172.A0A0D8XVV6"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="11">
        <location>
            <begin position="118"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="11">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="720"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="968" mass="111435" checksum="B33D8D9ABF4F51BA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW14</accession>
    <name>A0A0D8XW14_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716286">
        <property type="protein sequence ID" value="KJH47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW14"/>
    <dbReference type="STRING" id="29172.A0A0D8XW14"/>
    <dbReference type="OrthoDB" id="5860128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18521" checksum="7414AF7B791D81DE" modified="2015-05-27" version="1">MCAEQQRNLKKFEKRSSKNRALCSTFECVYPVDKQEILNNPVLLTGISGDTEMFFKMYLCASHSYEDQKCPSNCICFSATRSKANVLHFAAAYGNADFISTLLFPEESMLVDRSLSDHYKIMLERWLNSAISANGSFMFPFDVAVYYSMLTLLSYFSVCLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWG5</accession>
    <name>A0A0D8XWG5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWG5"/>
    <dbReference type="STRING" id="29172.A0A0D8XWG5"/>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18603" checksum="F2CACC4566D79AAD" modified="2015-05-27" version="1">MGGTYLRVSQIVQFMMLVYIFEFVHKITNSNCAADIEFDQKLISILESLSLIRFQSEQDVADVKMAVKKAKMLQNVDSENAEKMFTVWAEQECPMHDDVPEKPLTVKEVLSNATRFEDDYFVSPPGNVPLKETATLDLNLVNQWDKFGRPVAPMPKKQKIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWL3</accession>
    <name>A0A0D8XWL3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716338">
        <property type="protein sequence ID" value="KJH46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWL3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWL3"/>
    <dbReference type="OrthoDB" id="5859944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012339264" evidence="4">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="306" mass="34340" checksum="9D5E916C994DB081" modified="2015-05-27" version="1">MLMLTLFAIAPLVITQKITEEENCELKKHCGDHFLKPHGRQVRSIGGKRAERNEFPWIVAYFIEKHGLTKPPGTTGTLVGGCSGVQISKRHIVTAAHCVVTYDSNECKIQSRPKGFKYAPYKIDKAIDFKIFIGSQELKPTPDNSTIYSVKNITVHKDYNPCSVTKDIAVIEVTPNISHEHGSSICMLNKDEEESDDFTAVGFGSDQPQSHDILYYLQSVNLSKPEYKRRRIVLEDKEKSICRGDSGGPLTQIRTDEHYELVGVGIAAVPPLRKSVFLDVYFFVWWICEITGVCPLKDVSECSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX91</accession>
    <name>A0A0D8XX91_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_04628</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH49248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2oxoglutarate_DH_E1"/>
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        <property type="entry name" value="DH_E1"/>
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    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="674"/>
            <end position="856"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH49248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114330" checksum="CF9618B67D70C0FF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXJ3</accession>
    <name>A0A0D8XXJ3_DICVI</name>
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        <submittedName>
            <fullName evidence="2">GDSL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="26"/>
            <end position="44"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="420" mass="48061" checksum="8D6C9BDA7205004F" modified="2015-05-27" version="1">MDYEAYKEYYSIGRPPFYVHFRNRQFRLLAIALFVMVLIVVIMSRQSGINNFNTFLSLPHTRKSSPMSLNTNLSNSFHYQIHICVHTIGGELHCNPEMMKPSPTIPDDVNRVRPADIKVIGAMGDSITLALESINYDDDPYDVYPGNSYITGGDGTLKEHITVANILRLFNPNIIGMSYGSGKNDNSSFNVAVVGQTSIDIPRQARDLIQRMRTRGVDLANDWKLISIFIGINDLGGRQCLTEEQIDRTVYKEKLEEGINILRKNSNRTIVSIISMWNPRLILDAESLITKGEGMQCGDSHNFIARREHLYKEYRKVVYELQNEKRFDHKDFTVVVQGFLDEVKDAYRNKNGEYDKSFYGRDIYHLSKYGNAVVGKFLWNSLLEPVGRKTTKVKLADDSTPLMCPTEERPYIQTVGNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXQ4</accession>
    <name>A0A0D8XXQ4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXQ4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26119" checksum="88BB4312912DFE5B" modified="2015-05-27" version="1">MMSIAGVLDSLLWNTHACAIGCLAGTGSVLVYLLKYLISQMASDAQFQEQMKEVYCFEVFIVLQVDKVEKSEVNIHEHENSKKEVDNIKESEFCAQEKPEKRSCLVDNTEEKEVHAEAQKTSKKERKTSRIRSKRFTGFSCRMITRQSSKDVKEALFADFSLKDISRLERKRTVRAARKGKKQNDDPPSTSAEPAHKKIMSEEKDSAHPAETMESGVAPPTDPVDCTQLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYF5</accession>
    <name>A0A0D8XYF5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716256">
        <property type="protein sequence ID" value="KJH48779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYF5"/>
    <dbReference type="STRING" id="29172.A0A0D8XYF5"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF171">
        <property type="entry name" value="ACID PHOSPHATASE FAMILY"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="445" mass="51401" checksum="2E086F8D758DED15" modified="2015-05-27" version="1">MITNGRTLSRPTPQPEDEMNFLRILTVLNVLHDVFTQKRSTLQFVEFWFRHGERTPTRYMYFPSDVPLVPYSEAEAGELTNKGIQQAYQRGKFIRRNYDKFLGDTYHPSQIHVWAGDDNRTVISAEVVLAAVYEMDNEHSKLETLSWQPVATHNDPTIDWVAMGIEGLCTVYEKTFYESPEYQSILDAFNPTFIEFLENHTGVAIRSPIDFDHVTDALETKLMMNNFELPFPKWAEPIRLNITNIRSIFHQRIADAQRNTVGMYHSELFMSYIEDHISRPSRKKNRAVFISGHDVNLIAIGRQLNIAPLTTAIVPYAALLVVELHKINGSYFIEIWYASSLDDQLEQLTIPECGNPCSLGILRNILKDERLSRVDWELKCRGFGPQMGSDSIVIALILLIVTFFIATVMLLYRTLSYRKQLKDLKDPERRRLLLDNVDTLDNSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ15</accession>
    <name>A0A0D8XZ15_DICVI</name>
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        <submittedName>
            <fullName evidence="8">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ15"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ15"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="301" mass="32930" checksum="B97C217D01ADF4C7" modified="2015-05-27" version="1">MKIHAERGYLCQQCGRSFTRQQSLDEHTLKCKAKSAPGTATPPIKIEQPSPVFPLISQPFPSFNQEDVTKMAQSLIAQQQQRALAALFARQQAAAHLSTQPAVPSTIQPVHSMIPSLFCALCSKVFPNQPAFAIHMYVCHIQGSSIPNTGDEQRIPVLTSMNSSKKDSDDSHVNVISSTTTNPPCSPSPQDPMSTAVYETSSSTSEEMTNLPAADSLHRTLNQADVIPKFCTSCRLHAVRSTELEAALLAKGHELERFKEMMRVVVTTTGQLLNHCSPDNVFIAHTKNIFAQLQSNICSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ16</accession>
    <name>A0A0D8XZ16_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AICARFT/IMPCHase bienzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716226">
        <property type="protein sequence ID" value="KJH49695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZ16"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="178" mass="19503" checksum="7B684AB037E9A4EC" modified="2015-05-27" version="1">MSRISSMAYKRLQSSMSDESKPRSQSNSRLFDKLYLKGNSFNKAFEHTASYDEAISGYMRRQFAGNGERSIPLRYGTNPHQKADAELFVVEEQMPIKVLNGSPGYINILDALNGWQLVKELMDATGLPAAASFKHVSPAGAAVGLPLNDSEAQSCMVSDLPLDNRRPSLAAAYARARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0T1</accession>
    <name>A0A0D8Y0T1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="490" mass="55764" checksum="3E31FD1488ABFFF4" modified="2015-05-27" version="1" fragment="single">FISEIVDDVTSNIKSLRSVEKPEDILDQLGARHRRLVIAIISCSFVWCFGALSIMSSAFMSIDCGDNCTDSMQTVVNEFDLRDDRAYLSEWSMSFFMIGNMIGGSTFSYAADRQIWKTYSSTAMHVVPSIFSRLLPPSVLRFTSFLYADFFKGHAIREFRQMSVKNQGANIVAWVAAYEHSHTDFRSYTTFFFGLAWVIGYSLVAPYAYISYTWRDMMLWIAASMFLYTVWCWGLVPETLHFLVSKRRAKSIHKWLIGIDYSPPYHTDITNLLQPKSDENTSQNSSFFKEIWSHKIFILYCFVILYLWTCDNFTYFGLSLYSTKLAGNTYINYLLMGLVELPAYVLAPIFLEKCGRKYVVSGTHLLASICFLLPAFSMADNWLSLLCWMLGKFSISCSFMSLFVYASEVFPTSIRNVSVGLCSVLSRGGAIAAPYIRLLGSIWPKSPMFLLASISFVACLLSFLLPETYKKPLPVSIRQSALRSSDLRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="31867" checksum="3C79A60B92D640CA" modified="2015-05-27" version="1">MTKLRPSNARLQYYMKIYRLAASPDELWLAASDNLSRICLFKLSDCLSSSASDESRRLSHFLQLSEPVFAMRTVDQLLVCGDASGRIFAYDWAELVKRSDVSPKTVFSFGVFDGLQSPVAVLHEANGLLYCSETERLYVGGAADNAIREYDVNVPNKPIHVFSGHSATICELASASPEQLLSASADGTVRVWDVRKNTEGHVICVADEPKKFNNMNRNYAALGQNEVCSLFIRFFLKEVSLKVSRPKFGKCVSALAVDNKFMVCGGGVDLGIWHVGMYSLATPMEAENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y204</accession>
    <name>A0A0D8Y204_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5824711at2759"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJH50710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="71" mass="8421" checksum="934C300FF6496F2E" modified="2015-05-27" version="1">MMRVCEMVRGCFCDCFGPISRARSESIDKPLDPEDVRKCLEKYRAYEARQEMMACVSFIRFLLNFPFEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y209</accession>
    <name>A0A0D8Y209_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Animal hem peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716199">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="425" mass="48899" checksum="0562B2E1901E4DA5" modified="2015-05-27" version="1">MIRHTFVLIVIVRGQLIEKNMIFPVNNENFSRIKSILEQIWTNQHNRIAEKLKELNPTWDDEQLYQEARRIIIAQIQFITVNEYLPLLIGKETMDKYKIINSFDDFTNLYDETIDPNTLNSFAAGIGEFSFSSQCDRHHGFFQRQHLMSIQRVPSFDESSDAQMFIIVCKQDPFFDVYRNIDKYKIINSFDDFTNLYDETIDPNTLNSFAAGIGEFFLTMRSSSWILSTSTFNVDTERSLLYESVSDPGLHAIHTETYASVLPYKENTAAFLLHRGRDHGIPGYVKWREYCGGGKVSDFNELKNIVIDPHHLLPILTSLYRSVEDVDLLVLALAEKPVRGSLVGPTLGCILALQYQKVTQGDRFWFANNIGEEAFTLPQLQAITSGTKMANIMCKFLGINARVQPNAFLINDEFEKKRTCFDMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2J5</accession>
    <name>A0A0D8Y2J5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716256">
        <property type="protein sequence ID" value="KJH48791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2J5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2J5"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000025">
        <property type="entry name" value="Calcium-binding protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="368" mass="42674" checksum="5E46B353E5084C62" modified="2015-05-27" version="1">MGGHRGEHWNRIVANDALWIDFGRIVYGLRSIGMPLPIFGKSHKSPADVVKNLKEALVAVEKTQSDKKGDKAVEEVNKWLQMVKSIICGSETQDPHSEQVAQLAQETYNANVLPMLIKNLPKLDFESKKDVAQIFNNLLRRQIGTRSPTVEYLGARPEMLVLLVNGYQNGDIAVTCGHMLRECIRHDQLAKILLQHESFYKFFTYVELSAFDIASDAFSTFKDLITRHKTLCAEFLDANYERFFTEYQKLLNSENYVTRRQSLKLLGELLLDRHNFNVMTRYISNPENLKLMMELLREKSRSIQFEAFHVFKVFVANPNKPRPIADILLRNREKLVDFLAQFHTERTDDEQFNDEKAYLIKQIQEMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2N1</accession>
    <name>A0A0D8Y2N1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716210">
        <property type="protein sequence ID" value="KJH50269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2N1"/>
    <dbReference type="OrthoDB" id="5871932at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="326" mass="36139" checksum="13B7F268B9B400E0" modified="2015-05-27" version="1">MLDIYIFIETSFLGRLQLSKHQGTETLSTRGISILYSTNAGNVLGITVAVKITKYYHLPTVDNRALSLIQCETQTEFIKTRSIQTQMFEVCCRGTTVGSNTESRFLSVPELKDAVTNIVTAYLDCKGKLEAEQSIEKPALSIESSCANTRVSKPHLGKNIVSRLQKLRVLDKMIKERTLLVESFDSRFINSEIQRKRNLILRSRNVIDNSQNVKNTNESYATDDVAGKMDEIKHHITTIASKRIIPNADLVDVPSSTSTTSTSNGSEAYSEISDLHNESSSSSATSSRTSKNDESTSSSKATVLEMKSVVDVNDQKPNVDQEKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2U3</accession>
    <name>A0A0D8Y2U3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2U3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2U3"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="324" mass="35914" checksum="7DC2CB42A2CB5A65" modified="2015-05-27" version="1">MNLRGNFPTALASFARKFMFVTKYSAFCCYDYYQGSFVSVAQSFPYSNQVMVFGGTAVPFGTSTSSSVHLLSFDNDSDSVISSVISVEGEKLGTYGHAMLRGSDPNTFYVIGGTTGHNFFLDVDKLICKNGTWSWSNEATASPNIEGRYRLEAVLHEDFIYLFGGGRPDHVTELRTLTVFDTKKRTFIEIQTYPDESIKGDSNDGYPRGRRCHSVTKWKKDVILIGGCSADKEGVDARHEGGLLVWGGVLDIYSSVRTNTGQYCYLEPPSLRTLAALALRPYLHYKTIEEASSLRISRAVDLAFGICNNITGPLSKDHLVHSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y384</accession>
    <name>A0A0D8Y384_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7314" checksum="9E06889D377DFD65" modified="2015-05-27" version="1">MVKNQGPLSYEPTKSNYKLNLEKFCQQLDNLMGADQENTPMMFNSKDIILRHDNTGSLFKFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="36385" checksum="86835CEC6D024A8E" modified="2015-05-27" version="1">MFVCFLIIVYSSDCKCRYSTDELYRIPPDPKTSNSSRKTSSPPRKSAKNTGDRTSRCLFDDIDCSKLLSIICGHPSGRCTALLLQSIRQQVTVAASSEYSRKALEWIIKNDVLLLNAKKNSLLVRVLQADGVESREQIARLINTIASYTNGREYLFGHIRGFVNCIVPVLRGRRLPLTTQEQLIATIQKISIRPSCQRELLQYGIFEWVVNFLEGKATPYAVEYACSLAINLSLNLACSLFNSLVLVWLGCSRVRLRAKDTRLFEVLNTRNVKKICPLCDLHIPYLLAVIAGGRQAFIIVFYRLYSIAQHKHKSIPMHHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3M1</accession>
    <name>A0A0D8Y3M1_DICVI</name>
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        <submittedName>
            <fullName evidence="9">Helix-loop-helix DNA-binding domain protein</fullName>
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    </protein>
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        <name evidence="9" type="ORF">DICVIV_03109</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH50762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="38444" checksum="E3FB0DA56F70A369" modified="2015-05-27" version="1">MLCCILQEEKLFSVSKHVWTSQLSSSAVASSNVIGSDQVQIRSAPPTAEIRSSGDTNPWKLSDLGSTEIYAQPSYGLRLHDNDDSVQSSSSLNHMNMEVDTNDKSELKDERVLMSAPSSVKSVRGCSRQVQADSTLHPEERKRILHLHAEQNRRSALKDGFDMLMDMIPDLHSGGVKPTNAVVLAKGAEHIRYLTALKSEQSSQRAALIEKIARLNRRIGALQSNLPSSTGATSTKLEPRAALEAFYDRYTKERSRKDYRFWVLAQMLRPIAVGEPSSFSAMIAPEGSSREEIAASCSEWLNCHWRAAELRPLASTLLVHLATTAGVLTNPERLEEHVREQLNNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y3W6_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3W6"/>
    <dbReference type="OrthoDB" id="5861263at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336181" evidence="2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="32243" checksum="040D96051C9D6D23" modified="2015-05-27" version="1">MSYVFHLNVILLLFIVYLNSEANFIRQSSAVGAHFSSSGNMSPKEVRREHRERRILRRKKQRMRELREEIRNLTSSLQHMHMSTMERKPETEHKQKNRHGRKGLKWRKNLLEKLKTIVKRLDRMEKRIVERMQDIFTDSPPTNRTEMSLLSTSFAYDTLTTEITNEKMKRIQPAISRSRSGENGAICSSHNDCRPGHCCHRVINNNNDIKSFCVLYRLSEKAECVDGCQCSSHLSCFIPDRLSDLNVTNAYCKKATSSDILNGSYLYKKDSVITVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4F1</accession>
    <name>A0A0D8Y4F1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716234">
        <property type="protein sequence ID" value="KJH49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4F1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4F1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="384"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="498" mass="57325" checksum="B46B74C141DCD571" modified="2015-05-27" version="1">MYLVRHLEHSSWCARMGEKHAIKVDPIKAGPRSDQELMAHMAAQVGDGRLFKMDVDYTSQVDEALPKADAIAAKGNVVGALDSLTNLEKLTRLGSDMKSNTRIVQHMVKLCFDGKKWDLLNETILTLSKKRLIIKMAIAKMIRDACEMVEKMPSEELKMKLVDTLRTVTSGKIYVEVERARLTSLVVKKLEGEGKLDEAANLILELQVETYGSMEIKEKVEFLLEQMRLSVARADYIRATIISNKISTKFFSSDKEEIQDLKIRFYNLMITIGLHDSKYLDVCRHYRALFDTPKIAADAEKARVVLKCAVIYCLLAPHISEQWDLLNRIALMKEMELVPDYRALMELFINQELISWKNVIIRVYEKTLKKASNGKIFEGKDGEKRWKDFHMRVGEHNMRVISKYYTQITFDRLSELLDFPLNDMESFLCNLIVTGAITDAKIHRPSRVVNLRARKANMEQLDQWASNVQKLTETLNKVSHLILKEQMVHRNLEAMQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y592</accession>
    <name>A0A0D8Y592_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y592"/>
    <dbReference type="STRING" id="29172.A0A0D8Y592"/>
    <dbReference type="OrthoDB" id="5871622at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="25550" checksum="DB1A98323F8BC28E" modified="2015-05-27" version="1">MDLIIKSTQAVPTATQAPPIPEKELANPMSTNTAPNTPLPYSTAPSTPFIVQQQGLPIQTQASYPTTMNGIVGQVGPTSSVGASPPLSYGAAPAAVTGIPAYPGAIPMQPLGANVPSLGTNLPAMGINPGMAGMGTNPNQAGGINLVVNTNANSNTNSSPGATGGVNGAQPRPAPRPCPKCRMGYITRGQARCREICIKALAYSTICLTCLLPLQLLKTNYVDKCSYCGEEYGFRGELFEKPRPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5P2</accession>
    <name>A0A0D8Y5P2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5P2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5P2"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="136"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="406"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="590" mass="65713" checksum="E797D7E50EF88A22" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5T0</accession>
    <name>A0A0D8Y5T0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <authorList>
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            </authorList>
        </citation>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </source>
    </reference>
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    <sequence length="191" mass="21293" checksum="EFDD8E61ADBFFD23" modified="2015-05-27" version="1">MHYKLYNVESPFSTNHGNVKLFNWPQASKSKQVHVEIGTVANNEHRDEEGQVDFSCSYSHSFMAGDFITLHIVLGLIIPEQSIDVIVEIDKTVSLSELAVESSSTLGNCHLNSIDDFSCSKPYRDIISKCKNDSITHIWINTKPAGRILAQTRHLKQTAFAFGLATSLEIADHRLPLNETEASSTSCHYTV</sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="597" mass="66976" checksum="7880A93EBDA0AF47" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y856</accession>
    <name>A0A0D8Y856_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y856"/>
    <dbReference type="STRING" id="29172.A0A0D8Y856"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37416" checksum="8F64BFAC8A89A2A6" modified="2015-05-27" version="1">MAVEAPSRAIAHGLRRNASNRSLASVPVSYASSSSVLKSETITSPYPLKGRDVVLDLESRKQYEELRLDIRKLGGRIVDTIDEGKLPFVVISDHPSANRLETMKGVYSDKMILKDLPLLLKEAVRRKVKVRSYVTFQQQFARFKSRVRSARLLSNAPVKRSSKVDLNTKDRKVRLLKRPFIKWQDSCRRYAPSYKECPTPRWTTVYFGPAAGNCVFRRVTAEQLERRKKENHSLLQEDSDPRSSPGREKSAKSAKHYESKEHSMTATRPGVYDEVDMCIGAVVDYVVCPAAPSSVRLPDIIPTEDEPTAEASDYEYSEGIYKCTLLNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8R3</accession>
    <name>A0A0D8Y8R3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_01192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KN716162">
        <property type="protein sequence ID" value="KJH52607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8R3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8R3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH52607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="270" mass="30036" checksum="2047EDCD11DCC4EB" modified="2015-05-27" version="1">MSDYDKYVEQLRHPDNPIVFMEMTAGGAPLGTIVMELFADVTPRTAENFRQFCTGEFRKDGVPVGYKNSQFHRVIKDFMIQGGDFVNGDGTGMMSIYGAKFRDENFTLEHSGPGILSMCCNVGAVDEAHANAGTDTNGCQFFITCAKTDFLDKKHVVFGRVLDGLLTVRKIENVQTGANNKPKIPILVAQCVCCIENRYFIVVLLGEGAVGKSSILMRYVENKFISRHTSTIQASFQSKQLVLDRSSVTLNIWDTAGQEKYHALGPIYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9N2</accession>
    <name>A0A0D8Y9N2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716187">
        <property type="protein sequence ID" value="KJH51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9N2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9N2"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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    <sequence length="120" mass="14043" checksum="44BE82B35D61884B" modified="2015-05-27" version="1">MQMIGDFCFENHDKESFRRLTKNQPVGLKYVGIVLSLMREVTDALGNTIEVVVSASPLTEHNKPKAFIHWVSHPITAEVRLYDLSPQYKATVYTWLLKKLSNLRNAEEKRRPKMEEQMFY</sequence>
</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="65" mass="7552" checksum="76EEE5D8549F3A6F" modified="2015-05-27" version="1">MSFNTSREVVAPLERPFTIEEYFPSPFKRAWYKFYKMAGKNERPRGHSGATGPTGLVKRTKNTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAE0</accession>
    <name>A0A0D8YAE0_DICVI</name>
    <protein>
        <submittedName>
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    <gene>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="288"/>
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        </location>
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        <location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
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    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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    </feature>
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        <location>
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            <end position="186"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="5">HannoverDv2000</strain>
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        <location>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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    </evidence>
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        <source>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        </location>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035109">
        <property type="entry name" value="ASPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17641">
        <property type="entry name" value="ASPRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="12199" checksum="29B9BE25812FFEEC" modified="2015-05-27" version="1">MQILQHWDCGLENLAKSEFDRAANATTSYPLSEAAKTYFTLTSKGRNVRKALRRIPEIFLEDGQYLNKSNKFGCNTQKREVQLIACIFEPQYATNLDYQDEDSTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF21</accession>
    <name>A0A0D8YF21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF21"/>
    <dbReference type="STRING" id="29172.A0A0D8YF21"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16114">
        <property type="entry name" value="Ubl_SUMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000280">
        <property type="entry name" value="Small ubiquitin-related modifier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046332">
        <property type="entry name" value="SUMO1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="14989" checksum="64434A93080461EE" modified="2015-05-27" version="1">MGTYEVGFRTMLPIWLYIFFVKNITSIQFAIPPMDIPESMADNGSEAASAGDAGVEYIKLKVVGQDSNEVHFRVKSGTAMGKLKKSYADRTGVAVSSLRFLFDGRRINDDDTPKTLEMEEDDVIEVYQEQVGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-05-24" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q53CN2</accession>
    <name>Q53CN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NNMT/PNMT/TEMT family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6 7">Putative methyltransferase NNMT/PNMT/TEMT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_11639</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2006-09" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of an N-methyltransferase of Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Strube C."/>
                <person name="Schnieder T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2007" name="Int. J. Parasitol." volume="37" first="221" last="231">
            <title>Differential gene expression in hypobiosis-induced and non-induced third-stage larvae of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Strube C."/>
                <person name="Schnieder T."/>
                <person name="von Samson-Himmelstjerna G."/>
            </authorList>
            <dbReference type="PubMed" id="17112525"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2006.09.014"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">L3i101</strain>
            <strain evidence="7">L3i82</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="EMBL" id="AY542518">
        <property type="protein sequence ID" value="AAT11865.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY542519">
        <property type="protein sequence ID" value="AAT11866.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EF031334">
        <property type="protein sequence ID" value="ABK28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KN716673">
        <property type="protein sequence ID" value="KJH42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q53CN2"/>
    <dbReference type="STRING" id="29172.Q53CN2"/>
    <dbReference type="OrthoDB" id="10050085at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF39">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000384">
        <property type="entry name" value="PNMTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAT11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAT11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABK28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="30676" checksum="4211D3F0DED2B295" modified="2005-05-24" version="1">MESADGENLKQAILDRDTFHKEFNTEAYLKDFYTKVEDSAMQMVLIFLPNIVARIGKIKRVLDFGAGPTIHVAASFRNQAVEIYLADYLPQNRQELMRWYEGSSSFDWSHPMKMILTQEGNPWNDLDEMIRITRQKVRGIFHCDCFSSPSVDVSEQLQGMFDTVVTIFCVEYCCKTYDEYKNAIKNITQQIREGGFLVMGGILEETWCSFGGRMFSCLYITKEMMLNAIEEAGLRIENDCKCIMYNIDNMFMLCARKANTISDNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5A0</accession>
    <name>A0A0D8X5A0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="92" mass="10582" checksum="92EF8AF97CC3231A" modified="2015-05-27" version="1">MRIQVVVVIQQADGTSTIQSFMAQCIHQRILYNKQTLPHRIEEALEELKLVATKLEQKAPLPQVEMKVRSPLTNSITSIMSYIKMEEVIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="ARBA" id="ARBA00005562"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="70" mass="8212" checksum="689D21F664D5CA8C" modified="2015-05-27" version="1" fragment="single">MKKSMKGIFKLVDSKAVSRLWGMHKNKPGMNYETMGRALRYYYQRGILQKVDGQRLVYQFVDVPKDALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7S4</accession>
    <name>A0A0D8X7S4_DICVI</name>
    <protein>
        <submittedName>
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        <name evidence="4" type="ORF">DICVIV_13443</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <location>
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        <location>
            <begin position="8"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="40"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="112" mass="12331" checksum="FA622534619F3845" modified="2015-05-27" version="1">MVTVSTVLASTLNITDPSQAPFSQTVLPTPCPTSDPLLRSTSTIESPTTSTTSTTEIPLPTRKPTRPKTTCRDRYRFYCRRLAASGFCTSPEYDENEKREKCPATCGFCNNS</sequence>
</entry>
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    <accession>A0A0D8X7X1</accession>
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    <organism evidence="1 2">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X7X1"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="12900" checksum="663F74C800AF4183" modified="2015-05-27" version="1">MTPSVWCRRCDTSDYDFAYTECGADGSRWRVALPYHPGACEGLPEPKKGLNCCNLTKSNLYQSLFFDKFSHPTPCQPYCPTITFDAEMGNKLVPMNKTLAVINPYGNASDLLMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X857</accession>
    <name>A0A0D8X857_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717036">
        <property type="protein sequence ID" value="KJH40723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X857"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17129" checksum="49C13551F860D833" modified="2015-05-27" version="1" fragment="single">MEIIEEISSSRISPTPCVTSPSTIINVITTDLNEISTEAEIYKQYFFSHSESVADSSVSNENSIDTTGNITLNSELFNFSKSRSESSPLLLKSNYMTQNTSRSSHFRIVSDKLFRYSKKFESSKKLPECQNPQLKKTLIKFIETTTAHGIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8I9</accession>
    <name>A0A0D8X8I9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717939">
        <property type="protein sequence ID" value="KJH40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8I9"/>
    <dbReference type="STRING" id="29172.A0A0D8X8I9"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF115">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="193" mass="21041" checksum="29F707EFB604611F" modified="2015-05-27" version="1">MDNLLPAARPFLLTVYKNKEEADIAWEIMVSSRIYGLAFGCFMSVLLPTRHNRKFPMILGCVLDLIGILLTLLTVYVRMGMAAATIGRFVNGCGQGIAQTAGSVMMSELPPQKRGIALATLTVWACLGELGGMVFSLKELLGRPTTWHIAMCLPLLLLIPALCILVQVSEPTRDIISLEEDGQATALMLSYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9J2</accession>
    <name>A0A0D8X9J2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716875">
        <property type="protein sequence ID" value="KJH41228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9J2"/>
    <dbReference type="OrthoDB" id="5511455at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35373:SF4">
        <property type="entry name" value="PEPTIDASE_M16_M DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35373">
        <property type="entry name" value="PROTEIN CBG16894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="14248" checksum="424DDFCFE9B74140" modified="2015-05-27" version="1">MDGLYEDCFVELDNYVLKIKNYYFPSKKAKIVNVDSIQVLWFEEQGENSCSPTKIWGKSSASIYWAFDVKRRNHHSSDGKYNIVIDVGQPIRHGFSVMNGDGFMEAIRYLLDYHTIIVDSINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9P5</accession>
    <name>A0A0D8X9P5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716853">
        <property type="protein sequence ID" value="KJH41310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9P5"/>
    <dbReference type="STRING" id="29172.A0A0D8X9P5"/>
    <dbReference type="OrthoDB" id="5874435at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS central" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="265" mass="29815" checksum="693A7086FD946D22" modified="2015-05-27" version="1">MDKVKSAMKLCKDVSESVEAALYKFCGSNLNSTWYKSWTKSFIENVADCRNKAFYYRVLTGMISVQKVVSLDGNNMRKPEYSSPLDETCSVNKSAEQGNDARVSSDGDVSTLDPIVSTRGIVKKESTSVATKASSSTSKCDNKSKRAPRRSDGVQKTVHTATSLSTLDSILGDGAKDTTEQHLSHFYDVNCSICLAKQKSQAEAERKEKEEKERQREEDRRYREMLPPIRPYEFTEHKSATLIDLDYSANSGRDSADEVRQYEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9R7</accession>
    <name>A0A0D8X9R7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717280">
        <property type="protein sequence ID" value="KJH40374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9R7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="96" mass="10619" checksum="C51BE1B893F5EE1F" modified="2015-05-27" version="1">MFNKFQEVNTPHCAAELFLPVDKVKHKGYMTVVTDSGNASICETKKLDNKVVVVIIGEMACDNDMITLLHGGLRTPGKVNQPNITKHTQKCCFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAE9</accession>
    <name>A0A0D8XAE9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717038">
        <property type="protein sequence ID" value="KJH40717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAE9"/>
    <dbReference type="OrthoDB" id="5811289at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37976:SF3">
        <property type="entry name" value="PROTEIN CBG16927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28886" checksum="1085F0930C5CBB69" modified="2015-05-27" version="1">MQLMQRKFPYELKDTFHVQQVQLLNTKHYGYLHQYESSVRDPKTGFRYCEVVSRFQIHFNSFGPKKENLLIKFPSYKTAGVQFHEETNALGHKCFRMSGGRVEVYPPGLSGSKKYYVHLETRIGIHGKPERCVNADSNGCGGIGSWYEGNRPAQCSKEGLAPGSYNDIALKVCLPTKSELLPFLDQNSNRAEQLWDLFVSSRARSGEIPLVIAARIFDHPINNLSPKDMNDLLHNTKEGMIGCHWIYATVSQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAJ0</accession>
    <name>A0A0D8XAJ0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717024">
        <property type="protein sequence ID" value="KJH40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAJ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XAJ0"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="35867" checksum="643C68D54E80A0A9" modified="2015-05-27" version="1">MIGCRRLPRQSPLAVDTSANNMSVVDKGQRNNLPSRFLKSDQKHEHPVLCDPKTECSQTFQVIQDMGDGKHRQFYLQLPPGTSIADIQVYEPINSCEIYFDTAIYYPDAYIYPVGDNELTQALNNVAPMQFVTLAESNSFVPVQSNIPSSSTASTSNVVYATPASSSKSTLSHSSEPVLQIAEDEEIPNETAYMVVAAPVSKEEEPLYVNARQYHRILKRRAARQKLEAEGRLPKKRQKYLHESRHQHALARVRGEGGKFDKGKPQTTNDSEKTTESVSDLEPSQKRTRFLPVREMKSPSTSGSVSNPYINVESADGEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB29</accession>
    <name>A0A0D8XB29_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716762">
        <property type="protein sequence ID" value="KJH41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB29"/>
    <dbReference type="STRING" id="29172.A0A0D8XB29"/>
    <dbReference type="OrthoDB" id="5874194at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="37487" checksum="8E22476D199CC752" modified="2015-05-27" version="1">MTIRAWPSGSNYLFKSDTIVVSKDAKHSTKTARFDHTFNHGQSRSPATYTDVIHAKYGRKISPGSNCGEQNFTKQKKYNLKSSPLDSCEGNAFCVDGLCVCAAGMQPSSDGKCERIETSIPSVSSKSTLETGASVYARPGQKCSSGEICTGGSYCSKEGLCMCSPEKPYLHGGKCSVKQYSKTAKLGELCDENTTCTEGSTCDKDTGICKCPPDHITSGQQCQLPSTFSTVIKPLTTSLPLPHLKLPTIDATFIEATSSTKRELGERPIPISYAKYKVEPLPSKFVADLENIHKLLSSTVNSVLAPFHKLPSPTVNSVLAPSTQASDPSRITDPPMQRKMGSRQIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB41</accession>
    <name>A0A0D8XB41_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_13165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716988">
        <property type="protein sequence ID" value="KJH40869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB41"/>
    <dbReference type="STRING" id="29172.A0A0D8XB41"/>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="2">HannoverDv2000</strain>
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        </source>
    </evidence>
    <sequence length="326" mass="37176" checksum="9D4A570A2D44D65F" modified="2015-05-27" version="1">MLQQRVVMNLIGDELRQWENALHATAKPGIFTVARRIMVHPKFTKSYAYNTFVTLNSIGVEMKIFDGPSEIVQWIQKNLKLNTIQQCPFEMWKGGDTRIKKEVLKETGNRDLLSTKSNQRCPIFVWASHYQIAFKSGIFESEVVFTASGTRDCIGEEMYARFHNEKPKMRYCSAGRSGILEVPTNSSSIFLYFITDIERSITGPQLLDMIKEVQKITPDTHTAYIPIWWPHNQVSNVAKGIKISLDAEPLFSHGGFGDLAMEDAEPSAEYSKKFTSNIQHFDMVTVFHTPDTSSMIVNSKVIDMKTSNTGENDDNKPKQKKWCKIM</sequence>
</entry>
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        <recommendedName>
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    </protein>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
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    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD34"/>
    <dbReference type="STRING" id="29172.A0A0D8XD34"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="131"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="313"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH41672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="700" mass="79248" checksum="7C5BA790EAE25871" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDI8</accession>
    <name>A0A0D8XDI8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716638">
        <property type="protein sequence ID" value="KJH42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDI8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10275" checksum="50078773BA3A1444" modified="2015-05-27" version="1">MTSATTGNSSPVSFLFRRRRAERKLRRTLMRTELKNAMLELVHSAVEDGDGEEDECDQDESVDDEEDFNRQLEQAMQESCQELQSTSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDX9</accession>
    <name>A0A0D8XDX9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DICVIV_13401</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="KN717072">
        <property type="protein sequence ID" value="KJH40641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDX9"/>
    <dbReference type="STRING" id="29172.A0A0D8XDX9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
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                <person name="Choi Y.J."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26943" checksum="5E70C69951AD65F1" modified="2015-05-27" version="1">MSTTVFEVYFFCFLFIFYVRCSVIGNVETQTLRSECPNGWRRYERSRSCFMVLPKRLPWSEAEQACTEVGGRLASIIDEYENAFAFNLSKQANLTTPTVWLGRLVRLSRTGAYEWHDGSIGRQADGFRGEPPSGTELCMTMWLDFDNPEGSWNEWDCGYATGYSALCKRNIKHFASLLPSSSPADSVSTHTSRRCCLHGDCGQRCTSTEKCIPDDLNCWWRTCSYKEAMGWCIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF21</accession>
    <name>A0A0D8XF21_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Double stranded RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716684">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="941" mass="105869" checksum="98BCEA276B8E79E6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFQ9</accession>
    <name>A0A0D8XFQ9_DICVI</name>
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        <submittedName>
            <fullName evidence="7">SH3 domain protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">DICVIV_11427</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716649">
        <property type="protein sequence ID" value="KJH42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ephrin receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
    </dbReference>
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        <property type="entry name" value="SH2_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
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        <property type="entry name" value="P67PHOX"/>
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        <property type="entry name" value="SH2DOMAIN"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="407" mass="45518" checksum="5BE02D432FAB14AE" modified="2015-05-27" version="1">MSDDVSYVIVKYDYLAQEDRELTIKKNERLRLIDDSKNWWKVINDSNNVGYVPSNYVRRESLVDKARGTIKGFTKGRPRAPDFDPVSFCGYNAALDIRDSSTGNNNQMKGGQESPLKSVKSSSMASCAVAKFSYDPRLDDELKLVRGDTIRVFDKSSDGWWKGENNGRTGWFPSNYVEEIVDQINTNLNGNESANGCSIAGKSPMAVISLPAQSAQTQPVLEVSLSCYLTFIHSYVVIFQCVVALYSFDASTTEELSFRKGERLDIIEHPAHDPDWWLARNSTGHQGLVPKNYIEVVSTGNSSSGGLMDREPWFFGRISRDEADRLLSNGCEGEFLVRDSESNPGDLSISMRGVERNKHFKVQTIGGQLHIGSLAFPNMTSLIQHYTVNPIFSSATEKLYLMRPISK</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="346" mass="39281" checksum="02AA8DC38AD01483" modified="2015-05-27" version="1">MVFNVMSEGSPMQWSSMQSLKWCVEANLCVGPLGCPIGKAVVQRYPFRCPTKHSEEKGKRYTDALGRSLYAFSLALKDTNVTACLRNIRPDIGKIRAYWSDCDENANKCASLLAVSDEAKAIYIAYGGTTTKEQMSMELVNGFGAQLGAWEKFESSEAGVVSYFHKVFYKVFIDSGMKDELLSLNKKYPAHRIWITGHSMGASLASMTALYLSKKQLIDKNLLRLITFGEPRTGNVAYARDVEENIEFRYRVVKRNDFIASIPRSVDPTTSLITATMFERQPLFYRYLVHYDNNMSKGTDFKVCDLSDDFGCRNTMLAFDLIDHMSYFNINSDDFLAKKCPREMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGC4</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716533">
        <property type="protein sequence ID" value="KJH43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5850739at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7727" checksum="B22418F7D1759262" modified="2015-05-27" version="1">MLIHITNINAWKCGIGPISGAISYVVAIPGNLVGVNRCCVEHDDLIDKMHIDRKEADRVFCQCLSDNGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGJ0</accession>
    <name>A0A0D8XGJ0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NOL9 C-terminal domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">DICVIV_12530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716813">
        <property type="protein sequence ID" value="KJH41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="26828" checksum="DCDEB0254749E34C" modified="2015-05-27" version="1">MGLGAHLLEHIFDSARPCLAISLSDDCGIFAIPSWVPTVLRIYPNFISLSHEKLRKKPTRLLSSQLRDVAFISYFSSVLPRPVLSSICDAAPYCVDFKRITICVPEDYSYVDDRYFLATLNVQIVALCLEPNEELSVRRILDDGTFPLISAVRAHSPILKCCGFAIIRAVDLKKKLFYVLTPVPLSKLAEVTIFARGTGLLVPQILLETQPASNVPYLSRPALTSKCGIISELYSGLKSCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGW6</accession>
    <name>A0A0D8XGW6_DICVI</name>
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        <submittedName>
            <fullName evidence="4">C3HC zinc finger-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716517">
        <property type="protein sequence ID" value="KJH43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGW6"/>
    <dbReference type="STRING" id="29172.A0A0D8XGW6"/>
    <dbReference type="OrthoDB" id="5788149at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34528" checksum="5C48521DF11A6D50" modified="2015-05-27" version="1">MLSLINRTNMDGETSGSQTITEKPFEVLLRAKRKACEELSLLTQTISSVSSKRSKICLESFSTYKTLVKSYKLDLWAGNEISPRELAVHGWKCTAKNQVQCIACKQFLCTAMPKITDVDVDVYNRCLRRIRERILGSHVLTCLYRSKPIEFKHDVDESFLNNVLWPRISTYNMDGLVLNMTIPDDVVKYIKETKFSPSQEAVVAASLGWSVEIESIVGQKQFVAVCEYCAKNFILGHIAFDPIKTHRRWCPVLDVNEDSDIPLWTIIYRRITPAVQNTSSPVTTKEIERAKRTLDRSLSVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH39</accession>
    <name>A0A0D8XH39_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7930 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716596">
        <property type="protein sequence ID" value="KJH43064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH39"/>
    <dbReference type="STRING" id="29172.A0A0D8XH39"/>
    <dbReference type="OrthoDB" id="5822351at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057690">
        <property type="entry name" value="DUF7930"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25558">
        <property type="entry name" value="DUF7930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7930" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="203" mass="22052" checksum="38D128272F60D655" modified="2015-05-27" version="1">MQGCGKIVSLTESYAIVHSVTHGEVRCSLLSWIGGDGGTNAEWLTDILHIGDTILYSAVKRREENGLKAIKWTAQGFRIGDDQVTLADSYSQTAISFPEIGMRCLMGLARDDCSSLFDRTAGQTVVCAVLMSTNPPIIKDSTGVCSLSSLPNQAVAEEGDSCLFLFECSIQPPKCLRVTAIPNELVPIMQYQLAKFRGFHQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHB8</accession>
    <name>A0A0D8XHB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AF4/FMR2 family member lilli</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein lilliputian</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_12310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716773">
        <property type="protein sequence ID" value="KJH41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XHB8"/>
    <dbReference type="OrthoDB" id="5845605at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007797">
        <property type="entry name" value="AF4/FMR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF17">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER LILLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="14">
        <location>
            <begin position="180"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="33253" checksum="9B468FD4BD998EA6" modified="2015-05-27" version="1">MPRASSSQSHDGADQAQPSRSSSTLNNHSSRFGFECAALECAPAKSARPVKPKEDSTEMLYDFYQSVAKSQKRKGDAETDKVNKVLFYLDTAVYFILSARHVSSDSPENRGNRQYSIIRDTNDLLKRVTHAFSPPSEGCSPWHLHMLSRVRNLSSRCQSTMLAHMDAQIQEEQQQQNGSTINSSSPGSSVHSNSNQSTTFVSMPSKVYDLQRQQLKTLHHLMWSHRVWQDAAKRADVSNTDMAFISGLEKVCGQLFLDAPLEKMCAYMLTGIGWLRAEYEKEKARPPPPIVKRAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHG9</accession>
    <name>A0A0D8XHG9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716585">
        <property type="protein sequence ID" value="KJH43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHG9"/>
    <dbReference type="STRING" id="29172.A0A0D8XHG9"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="8">
        <location>
            <begin position="96"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="460" mass="52643" checksum="40B8660AD22B04E6" modified="2015-05-27" version="1" fragment="single">MDLQGFNQLVVQMQSPDNEKRSEAEKLYQEMELAPKASLLFSLYCTTDAPNESRVMCLVLLRRLLGSYWEKFWQDLGSNQKSFTDQLINMVMVESDDRLRRKLLAVVAEVARNTVDEDTGKQNWFELMQFLEHCMSSNDINEVEFIAVLLESVPNIFGAEQDHYMPRIKDAFAKLFKDIRSHIRSSAFRAFVTFIAENDDDDNLVKDMSSLMPLVVEVCRYTCTHDNGDDSPLQCLSELEAVAPKLVNPHLSSFLEMCIHCVLNTEKEEAYRHSATEVLATICESSTAVLKKRYSQSIFFILEAVLLLMTDLTMDLDEWLDVDEIEIGDDEDSVAVGESALDRIACALNGKYILSPFVALTGKLRQSEEWEERHAALMGYSVIGEGCQRMMEPQIEQFHPRVRYAACNAIGQMSSDFAPTLQKKCHEWGYGICVIIHRIYSMVNDEMKIWSYLRGNVFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHT0</accession>
    <name>A0A0D8XHT0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716571">
        <property type="protein sequence ID" value="KJH43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHT0"/>
    <dbReference type="STRING" id="29172.A0A0D8XHT0"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097524">
        <property type="term" value="C:sperm plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043401">
        <property type="term" value="P:steroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF45">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="146"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="421" mass="48088" checksum="096CAD93AC518B17" modified="2015-05-27" version="1">MWLLWSYWEDIVNESVTFLNYKSLEWPGPGLIFWFLVVVIVVRFLHIFESPAVPEVTLLEKSDSESMKNLIGSLDILKEPYRPPGLWGRSGHLQTVAYGLLGHSSLQRAFDRRASIHSKDGSTIMFDIFEPICKHKSGLDITLALTPGIANTSESNYIRTCVHYAQERGYRCAVLNHLGALTSVKLTGNRIFSYGSTEELNAMMNQLFVDYPQSHFINIGFSLGANITTRFLIEASEEQRKRILVGLSVCQGYSATISTPMYHDWENGRRIYNYFITENMKRLLRRNYDQAVAPHVAKGIIDEQRLWSATSIVAFDENYNRRVAGFQSVEAFYEWCDCLPHLLKLRVPMIFLNAEDDPIIPRALWEPVKNLVSRTNNMAFILTRHGGHLGFLEGGSFAPYSVTWLDRLIVDVADQAIMIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XII2</accession>
    <name>A0A0D8XII2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716546">
        <property type="protein sequence ID" value="KJH43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XII2"/>
    <dbReference type="OrthoDB" id="5870002at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="751" mass="84544" checksum="5DB456CEDB35941C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJJ2</accession>
    <name>A0A0D8XJJ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diacylglycerol kinase accessory domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716507">
        <property type="protein sequence ID" value="KJH44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJJ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XJJ2"/>
    <dbReference type="OrthoDB" id="5871383at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF109">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Diacylglycerol kinase accessory" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="26671" checksum="2DCACCF19183931A" modified="2015-05-27" version="1">MKKCIVILNIPSYSGGANFWGNAKDDTFRAQSFDDRLLEVVALFGVIHVATSRVPNVVRLQNHRIAQCRHIRIIILGNDPIPVQVDGEPWLQPPGILQIVHKNRAQLLVRNAAFDAILKRWEEQKERTMTPSTPTSLSLSVAACEEFSFAQRAGAFVQLVESEIAQLGVSSGFLEALEAAVLSVRAVEDEKMAVISTYMVALSDPVRGTKNVDSYEFTCLKLAPNASVRLAICCPGGRSHPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJJ3</accession>
    <name>A0A0D8XJJ3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716657">
        <property type="protein sequence ID" value="KJH42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJJ3"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11698" checksum="0E459A1AB882FFA3" modified="2015-05-27" version="1">MEKAPDMDVLLDELEEIENPSKPSMTFENLSDHCAVIEIPINLRRLSDKDSIRINLEPPGFSETRVRLDGNTLFICFFRTAIIYPFYAHYIVFEVHSLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKD3</accession>
    <name>A0A0D8XKD3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716490">
        <property type="protein sequence ID" value="KJH44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKD3"/>
    <dbReference type="STRING" id="29172.A0A0D8XKD3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="31402" checksum="629E4CD5EA45F106" modified="2015-05-27" version="1" fragment="single">VQGEFEWSKVTQGHILGAFFWGYLGSQVLGGYLATRFGGKRIIFITILGSSIFTLASPVAARTHAYILAGLRMAIGFLQGATFPAIHTMWSVWGPPLELSVLTGVSYAGAQIGNVFVLPLSGFLCQYGFDGGWPSIFYTLGIIGIAWCAFWMYMVSDKPNNHPRISEAEKQYITMAVEESVGKYTGKHPPTPWISIITSRAVWACWFGHFAGDWGAYTMLVSLPSFLKDVLGLELSSLGIVSAIPYIAYFIVINVGGFLSDFIRSRNILGTLNTRRAAMLIGLLTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM43</accession>
    <name>A0A0D8XM43_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-guanine transglycosylase, various specificities domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716557">
        <property type="protein sequence ID" value="KJH43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM43"/>
    <dbReference type="STRING" id="29172.A0A0D8XM43"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="11112" checksum="DCACFD9232D9E391" modified="2015-05-27" version="1">MKFEVLKSVARARHGVLELPHSTIETPVFMPVGTQGTVKGILPEQLMLMNCHIFLCNTYHLGHRPGHERVKQAGGLHKMINWPRSILTDSGGFQILMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMH7</accession>
    <name>A0A0D8XMH7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716390">
        <property type="protein sequence ID" value="KJH45720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMH7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12559" checksum="78F04083447F3C9F" modified="2015-05-27" version="1">MRSRKLYSKKCDASESPGHEGPLVWSVNKCDVRRERNMKDENRKRYAPAFILFFIIKSRDVLKDSSFVEARIACDVQLAIATATTATRATVARHLRQIRQQLDAISYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMM5</accession>
    <name>A0A0D8XMM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716381">
        <property type="protein sequence ID" value="KJH45878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMM5"/>
    <dbReference type="STRING" id="29172.A0A0D8XMM5"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00782">
        <property type="entry name" value="MutL_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="3">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="552" mass="61964" checksum="C6E69FB6A5AF23F0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP24</accession>
    <name>A0A0D8XP24_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bacterial group 2 Ig-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XP24"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1616"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="392"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="11">
        <location>
            <begin position="907"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1698"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1721"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1731" mass="189680" checksum="E652613933F57236" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPH9</accession>
    <name>A0A0D8XPH9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">7TM GPCR serpentine receptor class x (Srx) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716479">
        <property type="protein sequence ID" value="KJH44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XPR6"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000139">
        <property type="entry name" value="ras-related protein Rab-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23535" checksum="0B3781D20B1D7D5B" modified="2015-05-27" version="1">MSSDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLGDKRQVSTEEGQCKAKELNVMFIETSAKAGYNVKQLFRRIAGALPGIIKEDDRTDNTTIVNMDPIKQRQIVTDEGSCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPT3</accession>
    <name>A0A0D8XPT3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Exocyst complex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716389">
        <property type="protein sequence ID" value="KJH45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPT3"/>
    <dbReference type="STRING" id="29172.A0A0D8XPT3"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPT/TIG" evidence="9">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="10">
        <location>
            <begin position="159"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="898" mass="102899" checksum="40E31C9805E7B5A2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQL1</accession>
    <name>A0A0D8XQL1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQL1"/>
    <dbReference type="STRING" id="29172.A0A0D8XQL1"/>
    <dbReference type="OrthoDB" id="5849874at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10008" checksum="D6C3A80A6FCD165D" modified="2015-05-27" version="1">MPLLSRCAVTLNRVPQHGPVITVEDTGSQLRIKSSITDSLIDSNKASLDNATVVLCESNGSGTHPTASRFKRHNSRLVKIVSACKFNVINYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQW7</accession>
    <name>A0A0D8XQW7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716321">
        <property type="protein sequence ID" value="KJH47073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQW7"/>
    <dbReference type="STRING" id="29172.A0A0D8XQW7"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47073.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47721" checksum="B5CA8FFDA31664EC" modified="2015-05-27" version="1">MLFLEAVEASGVCDVKSVLQPFAIPFDDSDFLKISEMVSSSESNLYCAGSHVFSDHLLSEVVERLGDHIDTWVNKLITKFEQDRKGSHHQHKKIEADSEWSDSKRGGKKKGGRGSGGKINKSHEVMHEESPAPTIGVPSETLEEWVTKIGAVPEEILVDVVERIESRVDEKIRARLSEIAATHRNTAAQSQKRNLAQLQQQAQSLYTSICMFEDSSSSFPGMFFCLYFLNYALRTELNQYVLRNVGTELANAILSCASETENVHLMKEKQRDATIAALSVELRSGVSSLYNSLRESTLDNFHSAVFDLSSPKTLSLVLKHPDSKARTEMLEKYVAELREQVQVQSEPAAALLSCVLFLLARNGKPVAASGRFVAQLVRQLSDIVDQSLFENLVSCQRLVVHCLKNKDDEVSRDMLMSDIEKLKQAVIS</sequence>
</entry>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1066" mass="119041" checksum="88498CF970AD76A8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRE2</accession>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLIP_Serine_Protease"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47085.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="330" mass="36565" checksum="4FAA21B00C0B02E7" modified="2015-05-27" version="1">MLPLILLFFLPLAFSTIITRQENCYLKQHCGDHFLRGPALKFSPGKPAVGSRIRGGSKAKKNEFPWIVGFYHNGNAGCSGVQISQHHVLTSARCVVENSTRLQEQCKSGSIVSNRQKYHIKDHRHFTLFVGSGCTNPEHCWRNHTNYVVTNITVYKDYNPCDSSGDLALMEIFPPVLPTDGSPVCMAESKSLLGAKLTAVGFGADTLSVKNDSDQLSDLRYVVLSKTSENPSLLTMASYSKSICKGDTGGPLTRDTNQANYSLRGIGLFAHPPCDRGSPKEYRTSYFTDVRNYVDWICTNTGVCTIKDFATECNFPRLIILPPKNDRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM2</accession>
    <name>A0A0D8XRM2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_07540</name>
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    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716354">
        <property type="protein sequence ID" value="KJH46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRM2"/>
    <dbReference type="OrthoDB" id="5868167at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="16585" checksum="E297401D61AB5FEC" modified="2015-05-27" version="1">MTSLDERPSHFIQQQLKYLPGHSLNNPSYKARKVLFRHRDGRLLSGCGGDVEVFHPLELERSQNTGLPVRGTVVTVFSGKDTILGIKAIEHGDHLLVHGEYYCCLLHQSYLIEGGTVPEHRMLRLPASIRSVDVERHGKNDVRAEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRN2</accession>
    <name>A0A0D8XRN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XRN2"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000504">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000541">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="10">
        <location>
            <begin position="346"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1353" mass="151188" checksum="62C50E0724612B0F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSE7</accession>
    <name>A0A0D8XSE7_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">DICVIV_06330</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716301">
        <property type="protein sequence ID" value="KJH47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSE7"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8605" checksum="13AE9CDE1F47F1BE" modified="2015-05-27" version="1">MTQIVFLDIWEINASSANEKDIQESVVVFVFGHNRYEEISVLFLQPLEQGRSFTGNFRSIIPLNYVIVSKIDKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSG4</accession>
    <name>A0A0D8XSG4_DICVI</name>
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        <submittedName>
            <fullName evidence="2">BTB/POZ domain protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_08628</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716414">
        <property type="protein sequence ID" value="KJH45311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="50118" checksum="A214333E83079A82" modified="2015-05-27" version="1">MPLQTDSNFLGTHGFNFDFDTCINVRSNKEGNDIDERVLAHKLVLSSASMQFRNLLAAGIQSDESMAKIDIDLREIPNSINAFKAMLSGLYTGELNFTLADHAEILAVARHCQVPTIENKLLATNPDSNPFITFLSQPEFSLLAPNSPWQTYLHTLLAIYMQPCLLASAFGSNVIQYQSTSSLQSTSTPQVDDTRVSTTDDLSSELAMSTEFSEKIVPNDDKEGWCRNKKYIEKVESGFMCTVCRKIYGRYNSVSYHVTIYHRNPPIRHECDETGCQFSTREARYIHFHKYYRHHIPLPDSIDLGSRKCPFCRHVSKSPAMLEKHIARHVPERKGKTIESYSCDQCLYSQYMFFLSAYKSQQTSNTSFQLLNRNFPMKEKKKSHSADQMTTQFVCSSHDQTFRAGHLNIFHSFCTRAFISRSLLSVPYYVSSSKFFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTD7</accession>
    <name>A0A0D8XTD7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_06881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
    <sequence length="71" mass="8734" checksum="30DB2086EBDB280A" modified="2015-05-27" version="1">MYSVYKEKDEMLGRYYETGEFVPGQRGTRVVFSWGKIIGQYVFWFASFYAQYQIYFWIGRRIFVFFVSFFV</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="4">HannoverDv2000</strain>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX21</accession>
    <name>A0A0D8XX21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_04679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX21"/>
    <dbReference type="STRING" id="29172.A0A0D8XX21"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH49178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="409" mass="47511" checksum="E18CC559D36FE490" modified="2015-05-27" version="1">MGSILEKPTIVYIQMYIEGMSSFRAQTMDFQVDIYFQEKWVDSRLAHNGTRRILLKVEAKNLIMIKIQNKVARLISEFMDPHLFKLIWHPDIYFANARTSEFHDVTQPNFLVWIYPNGTIWYDCRISLTVLCMQNLARYPLDSQRCALRILSYAYDTEQIVIRWNGPNPIEINTEIRMPDMRLRTIQHNIRNDTYATGSTSHCRIYKKQDVAAFSFIVLTACVATWEPEVISTACGSYVPTALIVVISWFSFWLDVEAVPGRVSLSITTLLTLATQSSAARMALPQASYVKAIDVWMGACMAFAFSAMIEFTSKNGTAYETFSYKYGTGSNIENKWLQESNQSAFLIRRNVPSTAKQKLIDHRVNQVDENRKYAQMIDRRSRVLFPMVFVLFNFFYWFYYIKYAVDTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXA2</accession>
    <name>A0A0D8XXA2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">STAS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXA2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXA2"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="354"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="498" mass="56783" checksum="DEF5EFD388A50AFF" modified="2015-05-27" version="1">MAVFSIPQGIALAGITGVPPVYGLYTAIFPSFFYMFFATSKHNALVEFEISLDDARKEACMQNMRLYDLIENISNIHWPTVAISVSSFMFLIFSKEIMSPWLSSAFCYPIPFDLILTIVGITATNYAELSRRHHVKVVGNIPTEFPPASLPRFNLVHFIGVDVIAIALTAVAVHSTVAKIVEKRYKYKIIHGQEFYALGFAGILSSCFPTFPVTSVFARSVVGVAVGGSTQLTCFFSSLALVFVILYIGPAFQYLPQCILSTMIIVSQKPMFTKLTEFRELWPVFKMDFTIWLSSIFLTVCFDVGEGFLLATAFALLTTILRMQRPKWHFLSRDCNTGNFKEVERKNLEFVDGNVCVFRMDAPLIFISVDRFTTAVWESVKKWERSKAESFVTIVEMNSTFVNNIFDKKAKTSKGFALEDRCRFIIDCNGFPYVDYLGLTTLKWVVEDLLNSNIQTYLVVQRRDMRKLLEVTNFYDTVDRRRVFEKLEYAMEQAENFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXI8</accession>
    <name>A0A0D8XXI8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibulin C-terminal Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716266">
        <property type="protein sequence ID" value="KJH48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXI8"/>
    <dbReference type="STRING" id="29172.A0A0D8XXI8"/>
    <dbReference type="OrthoDB" id="5819528at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibulin C-terminal Ig-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14864" checksum="416238219F6D15B3" modified="2015-05-27" version="1">MFSSIQDGYSCLKVCVEDDAVCLANHTKEILYQFRALPSTKYVKHPIEVSRIRTQMNTPFSVDYFLDSVGKRHFVLEQDRNLGIVKLVRPMVGPGMERIRVNIHTKSRTGVILAYNVAIIEVYVSRHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXR1</accession>
    <name>A0A0D8XXR1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XXR1"/>
    <dbReference type="OrthoDB" id="5858510at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="17997" checksum="31461B49580F9E7B" modified="2015-05-27" version="1">MCPAAPAPVRLSRLPVESTLLTPPWKGVNIEELPEKKCRISGFQTTNVTSFSSMHIPLQTDVQVAIDDGMVVADVSSGGSPVCWDDIGIPLECMLDDKNWTQVGLLQSVTRFVEDEENPSMSECDDITTLMFAIFSDNTLAESLENRAVEVFTWSRKCFSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXX9</accession>
    <name>A0A0D8XXX9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_05257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KN716261">
        <property type="protein sequence ID" value="KJH48629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXX9"/>
    <dbReference type="STRING" id="29172.A0A0D8XXX9"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="462"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH48629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="893" mass="100676" checksum="E83454C2599980A6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY30</accession>
    <name>A0A0D8XY30_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S19e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_eS19"/>
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        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01090">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="16686" checksum="EFCB4F1FAFB9FEB4" modified="2015-05-27" version="1">MGKATSIKDVDQHEAVKQIAHFLKKSGKVKIPEWSDIVKLGTSRQLAPVDPDWYYIRTASIARRLYIRSPAGVGALRTVFGGKKRRGSRPNHFAKGSGSVVRKALQALEDIKWVEKHPDGKGRVLSKQGRKDLDRIATELRQHAKPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY51</accession>
    <name>A0A0D8XY51_DICVI</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY51"/>
    <dbReference type="STRING" id="29172.A0A0D8XY51"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="169"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="393" mass="44782" checksum="533A79AA6816D0DD" modified="2015-05-27" version="1">MPPKKDFRYEVNDRVLCKHGLFFYEAKIIEIEEEDGEMVYTVHYQGWHKRYDERIRQLHCSEMFLPLTDANIAKAKADIQEASSTKTKRKKQKVEDDEARKSETGSRGSTPSDRAGSSSHAPSTHSDRRPTSSKLSDTVKKASDDSGDKRVADYQLGPEIDAQLELLGDLPRPIKKILVDDYDAIVNQGKLTKLPARVTVYDIVQKYIDFSNKLYGNATAIDIEMHGITRVDGVNSLRATAEGLRDYFDIVLGYQLLYKFEKPQYLALSKTEEANYEKDLKAMQESCSKKTRKPARDAKPLLPQSAFSQLSEGGPLRPAMLRPSKFYGLAHMLRMFVKLPALLRMTCWDEDEILMRIACIHDFIAFLRQNAPFIWSMDLDYKLAGAEYAKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZC7</accession>
    <name>A0A0D8XZC7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716297">
        <property type="protein sequence ID" value="KJH47676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZC7"/>
    <dbReference type="STRING" id="29172.A0A0D8XZC7"/>
    <dbReference type="OrthoDB" id="5813772at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF6">
        <property type="entry name" value="TPM_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336248" description="TPM domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47676.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39535" checksum="E765F7B5BC4149C8" modified="2015-05-27" version="1">MRWLIILLLLKTKCQAEEWDANNFPNPTAGQFLKCRMKTTANICDPDGVLSEQARYRLDHDLKQLESRTRQDHGRTFCEKKGVTAAMAVTRHVKGGSIEAVKMMANDILRKWTLDTQCQKAVVFVVSTDDMKFWVARDDRVPVYADEFTEIFEQQKSLFQQSNHQQALTNIMQKTWEKALSKQGSPKAGGGQPGPYPPSGGDSGMMDGGFKGKGGPDFKMPSIPGWFWAALVLVIIPLLCLCICCYCCCCRGKGSAGARAASRGVPMTDDGGMGGGSHRGGGGAGSMFRNIAGSAGGAGIGSLLGNLISGRRARGMGGGRYGGGMGMGGYGGGGYQGGGAYPAAPAIYDDNAGEGGGGLYPSKAVKDQGGGGSWA</sequence>
</entry>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XZD5"/>
    <dbReference type="OrthoDB" id="5820519at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7523" checksum="35F41A5466881F92" modified="2015-05-27" version="1">MRKRPGKHATVAVICLIWILAVLCGIPAFLTSKLELNYFFDGETLFADTLCLADNYPDGSSQTSTLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZJ1</accession>
    <name>A0A0D8XZJ1_DICVI</name>
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        <name evidence="7" type="ORF">DICVIV_03996</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="Ras_GTPase_bind_prot"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
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        <location>
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            <end position="406"/>
        </location>
    </feature>
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            <end position="248"/>
        </location>
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        <location>
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            <end position="455"/>
        </location>
    </feature>
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            <end position="234"/>
        </location>
    </feature>
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            <end position="244"/>
        </location>
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            <end position="420"/>
        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="455" mass="49544" checksum="B8515D03854FAEC7" modified="2015-05-27" version="1">MKMNVVDDLVIRSEPTYTETDPTPDVIGIEFVRQYYTILSKQPGNVHKFYSHESVFVHNDVTVIGQQKIKNCIEQLVEANNRFKIHSVKGSFTSNKGIVLQVCGEVSTRRFFQTFILAQQSAKKFYVQNDIFQFVDVAFHCESQDSPAPPVSNEAPITEAQSVEIDLVQNGHNHSHSSIALSCEEAPILTSVVSHAKVSPVKNPPTAPLAQETSTKGSSPVEEATKSRLDKAKSETTSSPTDNVPKTWAHRVGVGSKNTTAPAAAVATTKSSVTNVANATTTRVQQSTRSNAQANGSANNQGERRIYLGGIIRNIVPDNTNIAEQEIKEAFSKFGDVESVAIPRKVLDQPNDTSRNGFAFISMRTAVDAHNVFQKARKDDRGNYHLQLRLDAFGFDGEVTISEQKDRVDRPGGGFRGGRGAFISRNGANSFSRGNGGNRGRGSGGGFRGGFQNQN</sequence>
</entry>
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    <accession>A0A0D8XZS1</accession>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716241">
        <property type="protein sequence ID" value="KJH49244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZS1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13212" checksum="DD8F48DE28C7C67B" modified="2015-05-27" version="1">MHIDFGTRNTDRRRQLTALNKSLTIYEDIKEELNAYLDIQTNYMNSLLSLMNLIVQLFMLFCICEAVDAILTNENLSIFNANTTMPFTTSTLISFYLYASNSPPKNAQTSMLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0D2</accession>
    <name>A0A0D8Y0D2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfotransferase domain protein</fullName>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <source>
            <dbReference type="EMBL" id="KJH50019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="568" mass="64889" checksum="1C9F9A9FD96A9192" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2F7</accession>
    <name>A0A0D8Y2F7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Ligand-gated ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DICVIV_02730</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2F7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2F7"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000105">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000439">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="358"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="368"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="833"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="700"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJH51063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="872" mass="100674" checksum="FE4E851E58308A13" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2I0</accession>
    <name>A0A0D8Y2I0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716207">
        <property type="protein sequence ID" value="KJH50372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="MEROPS" id="M12.310"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF793">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="552"/>
        </location>
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            <begin position="138"/>
            <end position="338"/>
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    </feature>
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        <location>
            <position position="234"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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        <location>
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        <ligand>
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            <dbReference type="PROSITE" id="PS51864"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH50372.1"/>
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    </evidence>
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        <source>
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    <sequence length="552" mass="62460" checksum="98303B67626E3281" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8Y2S7_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
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        </source>
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        </source>
    </evidence>
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    <sequence length="248" mass="28721" checksum="E8FD7F84AEA69EEB" modified="2015-05-27" version="1">MGISGLWPILEPTCQPVRLEVLEGKVLAVDVSIWIYQAQLGYPGDVRCPHLALLVSRLCKLLYYKIKPIFVFDGLSVPSMKKKVLNERRLRKHAEEVNLTSTKKRHLLDFATIASLVAYIRYTCTYCFDFYMECYFACSQTQVEIEAIKTKLAAENSKRNRIENNLFDILPGKPIELLDVNDDDDVVLTKKMCYDTSGANPIESLIEERERIRAARLRPSQVRYFQFFVFIQLLCIRNRWPTNTLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3M0</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="251" mass="28831" checksum="04EC80A6677634BB" modified="2015-05-27" version="1">MKKLQVCCNVSRVKIWNFNSVSNFNVSRIVYESDFSFNEDDLYLNLQLSICTDRLERTIGWIEPKPGVKCTYSTLQTLNIPHGALTIPNWYVICFVLNKNCQICRIDILCESDLTHACANRHVLGSSPKATNSSIHYWFEAGDKFPFENSSYIELKVMKQNDDQIVVHDEAGEKKTLTLSGLDSNEVYGIRRCIVIELPTLLTNDQRFSFDNSSNRVCTEEIYRTLSNTMFIRSIWITVLFVISIPSCLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4L2</accession>
    <name>A0A0D8Y4L2_DICVI</name>
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        </recommendedName>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
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            <begin position="164"/>
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            <begin position="257"/>
            <end position="290"/>
        </location>
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            <begin position="307"/>
            <end position="340"/>
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            <end position="731"/>
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        <location>
            <begin position="200"/>
            <end position="226"/>
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            <begin position="202"/>
            <end position="219"/>
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            <position position="699"/>
        </location>
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        </source>
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        </source>
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            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH51788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="732" mass="85063" checksum="19B812CF49600604" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4T4</accession>
    <name>A0A0D8Y4T4_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">Rab3-GAP regulatory subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4T4"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RAB3GAP_N"/>
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        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="449"/>
        </location>
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        <location>
            <begin position="843"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140538" checksum="93BF5B75412A411E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5J6</accession>
    <name>A0A0D8Y5J6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716222">
        <property type="protein sequence ID" value="KJH49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y5J6"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="422" mass="48454" checksum="5408AAA043D731E9" modified="2015-05-27" version="1">MASTPSLFVPARPYAVPSRVRAGRERRMTVPDRPDHPINLWSIMKNCIGKELSKIPMPVNFSEPLSVLQRITEDLEYASLLEKAATLETLEQLAYVAAYAVSNYSTTGNRTNKPFNPLLGETYECDRTGDLGWRSITEQVSHHPPAAAHFAEGNGWVMYQDFTMTSRFRGKYLSVIPVGYTHVYFPGSKNHYSYKKVTTTVHNIIVGKLWIDNHGEMEIINHGTGDKCVVKFFPYSYFSREVPRKIYGVVRDSKGEPKLVVQGTWDSSVDMLRVVKVTGSGEKTKIETELEPTRIWTVNPPIPGAERMHNFTRLAIQLNEPEPGVAPTDSRLRPDQRLMEEGRWDEANKKKLELEEKQRTLRRKREAEMEKAMQQGLSYEEYQPKWFQKTQDELTGTLIHKYLGEYWEKKALGDWSNCPSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5T1</accession>
    <name>A0A0D8Y5T1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5T1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5T1"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="34331" checksum="A79D2C336167A29F" modified="2015-05-27" version="1">MPEGPKEAFVANESKNRYRDILLLDNTRVILRNRECDYIHASRVTIGRNVFICTQGPLCNTAESFWAMVIQEKVKYGLYLMFILLHIQKRDDELDWREVRRESAIYVQNRINTVLSEGLIVMLCKFIEEGKEKCCEYFPKREGSLEIGKFLIECKSREVIPETDGVTCGKLEVTYMGKKTKVLGRSGCFVAVELALHEAATKSVFRMDTVLKDLRDQRMHCVQSDMQYLFVHRGLVEFLITRGVTKRMDVLKFITDYDNLIKRKRGKADSADGKENRAPPKKAEYTPSVYCNDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5X6</accession>
    <name>A0A0D8Y5X6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5X6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5X6"/>
    <dbReference type="OrthoDB" id="5855827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF19">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="166" mass="19171" checksum="2B39CC18C88DCE48" modified="2015-05-27" version="1">MFVTKHCYIANAVGGYNNTKLEPDTRLFFKYKLNEPCTIEMKITNTTKDRQTFKVKCTDNDIFRVRPPLSFVKAEETAVVKIILTAKTPPENNRHFFAVYHMKCNDDTGKTARQVWTPDSKAEGVARIIAVFEAAESGEKKHFISLRASWWQHWIGMNYFLCVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7B6</accession>
    <name>A0A0D8Y7B6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pseudouridylate synthase 1 homolog</fullName>
            <ecNumber evidence="12">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA pseudouridine synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_01676</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Forms a complex with RARG and the SRA1 RNA in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="12"/>
    <dbReference type="EMBL" id="KN716170">
        <property type="protein sequence ID" value="KJH52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="20">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="556" mass="64495" checksum="C94F1942252BBDC5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7J9</accession>
    <name>A0A0D8Y7J9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7J9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7J9"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="250" mass="28224" checksum="B0427CB71C1CA243" modified="2015-05-27" version="1">MKHVCDSRKKELKILKEDVLLLSVVRLRQVCASAAIGIIVIPSWSYRPFEGMPLGLFGSHSKPQPLTSVDSGGYKEKKEGPEKDGRGTVLRLEKSIVTIEKKLAEGGFAIVYLVTDKNNRQYALKRQFINDDSKQVDACRREYQIVSSLKGHKNIVEYVDHLLVKNKTASVLQLMNDRLHLGQSFRSHEILSIFCDMCEAVARLKIFSSMKEIGQVAQFTCCVILEALQRRQLATVEMVDACVEQCMLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7V6</accession>
    <name>A0A0D8Y7V6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7V6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7V6"/>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="161" mass="19127" checksum="E3DB2CC1985262A8" modified="2015-05-27" version="1">MKNLLLSQHYMNVMVKIYSADELPVYLSALFENSIDFIASLNLPGEVSITSDDLFPPSIHQNTFEFFKGTLATRNRNSSFVHNRWMQFDLFMFVTHWMSWILHLYQIVRNDFSLTSLPYENWFGVIRSVRPFIIIRLIRLVVKFKLPKERIEQLLNNTSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7X6</accession>
    <name>A0A0D8Y7X6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">IC domain protein, HAD ATPase, P-type family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7X6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7X6"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="370" mass="40254" checksum="57FB31E3AF03A21A" modified="2015-05-27" version="1">MSVIVFNPSKDPHSMTLYCKGAPEMIHSLCNPVTIPDDYYTVVNEYAQHGFRLIAVARRALNLNFNKAAKIPRTKVECNLELLGLIAMENRIKPVTMGVINELNRARIRTVMVTGDNLLTAMSVARECGIIKSSKRAFLLEHCSGIFDSRGRTKIVIKQSVSSPAEMLEEDFLFSKPLSGPTFAVICHEYPEVLSSLVCACDVFARMAPDQKQQLVNGLQEIGYTVAMCGDGANDCAALKAAHAGISLSDAEASIAAPFTSKVADIRCVPTIISEGRAALVTSFGIFKYMAGYSLTQFVTVMLLYYISNILTDGQFMYIDMFLITLLAVLFGNTSAYEKLCPTPPPTRLLSASSICSVLGQLAIMGGTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Y0</accession>
    <name>A0A0D8Y7Y0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="12">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_00832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="12"/>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7Y0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7Y0"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="370" mass="41337" checksum="085538BECFD7A845" modified="2015-05-27" version="1">MLLRKINFGAGPAKIPPEVLLETCDGMINYKGTGIGILEMSHRSKEFADLLEETKSLLRQLMNIPDEFEILFMQGGGSGQFAAVPMNLKGTHEFADYIITGAWSSKAAQEGSKYIRVKRVFTPNKPYVTIPDEEQWDHDKEAAFLYYCANETVHGIEFPTSPHSVHGVPLVADISSNFLSRPFDFTNHGVVFGGAQKNLGAAGLTIVMVRKDLIGKLSSVLHLPITPAILCYKEMKDNNSLYNTPAVYGVYVTNLVLKWMRDRGGVEAISEMNKNKAKMLYDLIDSSNDFYKCEVDKKCRSTMNVCFRIMNGDEQLEAEFLKGAVDRGMISLRGHRSVGGIRASLYNAITTEETAFLAKWMREFMDSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y896</accession>
    <name>A0A0D8Y896_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_00824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y896"/>
    <dbReference type="STRING" id="29172.A0A0D8Y896"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="271" mass="28999" checksum="C013E10E97BDA305" modified="2015-05-27" version="1">MWFQELFSKVIVNVSQSYPETPLSKHICLQLSSQLAEILKKWPGGQINITAAGDVARLKLNRPEKSNCLSGEMMLQLGEKVKELANLSSCAVLVIEGTGPSFCSGADLGLIDQVSVARLHGHCLGGATEIASSCDLRVAHKDAKVCQFNSSIGFLQSRMGIVPSWGGAAYLDSIIGRSAALRVMTTAPILTAVDAKSIGYVDVLYDTEDDFEKFVSSMTKNGADVCKAQKAMLNAYKHGGDPNAVIRSVWGSDAQKAAIIKQMSAVMDKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8D8</accession>
    <name>A0A0D8Y8D8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y8D8"/>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000215">
        <property type="entry name" value="VAB-10B protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF23">
        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="4">HannoverDv2000</strain>
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</entry>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        </location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH51066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KJH53613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36249" checksum="8080AA48B3996994" modified="2015-05-27" version="1">MVLCASYNLRAHLSTLPYQAGEGCHIEPPTNVPSHFVASKPISLRSPCSMLDELNGSSRMEQLYSPLSSSADSMHCIKSSSSSRSAIEREIERQQRRQLLDTSLLKMRASNNMPLRKHLLVYNTVKQLQRDLDLLDDEELYCNLMGDSCGERMDVDEPRWPFGATSATSVTLSASAVSITDIAQTAPPQKEERRVAEEATSLISEDLDIDLRQDVREASQTPLAIWSWNNSTIQRDDHTSKSSRDLFESIQDAMGDSFTVWSWTLGSSEFSGDTWWTGHEKTSYESASRLEPMWRVAADPLGATNLSRFELQHLFPSQVLLQA</sequence>
</entry>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Golgi-PI4KB_interaction"/>
    </dbReference>
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        <property type="entry name" value="LD35087P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51501.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="29022" checksum="AEC16A8572CDEEC4" modified="2015-05-27" version="1">MFQQSALIRQLQDQHYQQYMSQVYAQHADAAVPESERRSTAEFDKEQRARNDDDSDLSDEEPGDDLPSNPQIAPASLWNRKDIVEFKNTIRKEGSEGIIKVGYGETVTVRVPTHEDGTCLFWEFATDYYDIGFGVYFEWTIADSNQVSIHVSESDDEDEYDETAGEGNDGASPGVRGSNPAVGDIESGKSARHLRDPNKPRQDEIIPVYRRDCHEEVYAGSHSYPGRGVYLLKFDNSYSLWRSKTLYYRVYYSK</sequence>
</entry>
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    <name>A0A0D8YAR8_DICVI</name>
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        <submittedName>
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    <organism evidence="7 8">
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
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            <end position="934"/>
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    </feature>
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        </location>
    </feature>
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            <end position="1667"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAY7</accession>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC94"/>
    <dbReference type="OrthoDB" id="5871338at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="373" mass="41444" checksum="DD593D511AB5EA06" modified="2015-05-27" version="1">MAQSNDVEIAKVPYIDSSDSNSAKSVENVGEINIAASLDEAIMSLKSVIAVEENSNMIENQAFVVPDSKANEKTQNKSYGSDNVNVIMGTASSSEKTLIANECEVLVNNEFRHSSIDQPIYAAGETKEMNSETKSHFQFVQTQFESPQFGTSHRLPKRLDCRGIEEIHISSIPISTRVVNKQEETKNANITVVNRFSTSTGVSHEDTHSLKTSRTENIPCNNLEQEEILKGKNSNKTPIMQESSAEQTHAKQTHSNQKTPDDKITKKKPLSPPPKPQRRNIDEVVPMDMVTNPAPPSTSPTPPPRKNSLMTQIAPPTPSLSIRSFNRHSSVASSRINTMNYNISRGILTFPTLPRNARPPTREQLQYARNRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCA0</accession>
    <name>A0A0D8YCA0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCA0"/>
    <dbReference type="STRING" id="29172.A0A0D8YCA0"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000876">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="58"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="350" mass="40563" checksum="850C132A76E041DF" modified="2015-05-27" version="1">MNICCPPLVKLARSIMTKEYLSTAVSPEKLIPDLREKFVLPPNFDYRVWFPMHMYVQMEKMEAKLRSVDLIVEVHDARIAVSGRNPKFFQHFSSIRPHILVMNKMDLIDLKKYKQPIEDYYRYEQGINNIVWTDCKRRLSRAMSKVQQSVLDVLAREPRFNRTVRTDYLVMVVGIPNVGKSSLINTWRSHNHGTKKSAVAEGARPGVTVRVQNRVRVMDRPPTYVLDTPGVLSPKTSNIDEVMKLALCNLILESATNPRYVADYLLYWLNRTGDYSYVKHLGVPGGPIDDIDKLLLRICSTKNWQTRCLVGTDYEVRWDFDRAIALFISLFRNAKLKDCFLDKDVIQAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YED7</accession>
    <name>A0A0D8YED7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YED7"/>
    <dbReference type="STRING" id="29172.A0A0D8YED7"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11374" checksum="14B54E7A9CE13AA6" modified="2015-05-27" version="1">MSCTETEVTKTETVTGDQSEFVLRLSRDPERPHVNWTADTVDNENMGKKKSKCCCIYKKKKTWQDESSSDDSDCETGNCRGHVEKKKDSHTPPQGGNDVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF43</accession>
    <name>A0A0D8YF43_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF43"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="8940" checksum="FE8980ED4F519769" modified="2015-05-27" version="1">MLETLDVRIKHGFTTTPSLVIVFMLQLLQADDSHSFAQMRLKRWSIESCISIPSTLVLDVLDGGDVVWDFERGACGRVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X522</accession>
    <name>A0A0D8X522_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722625">
        <property type="protein sequence ID" value="KJH39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <begin position="48"/>
            <end position="66"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7944" checksum="D06C80EC99CD0B68" modified="2015-05-27" version="1" fragment="single">MTELGDSGKNWVAQHHMCFFFLRDGSKAVSWFFKLIEYYESSFSISDGMWFGYFFLFLYIGECIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">DICVIV_14347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
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    </dbReference>
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        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14101" checksum="41D619BA8E6C8C5C" modified="2015-05-27" version="1" fragment="single">MRIDSLLNALFSIIIQLRGGYLLNNWLNNALNVANGTMTKPNRMLLYSSHEGTLLSLMYAMGVANDRLVPFASSIIMEIFKDGSDYYVELLYRNDTTTPPYLLEIEGCQPCTVQKLLKRYGRMV</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721667">
        <property type="protein sequence ID" value="KJH39697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7E8"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="12126" checksum="6D185F737C8F2C24" modified="2015-05-27" version="1">MKSYGLSAKHHQRSEACQFRIQNSPRLLTFSWQCGEHRSGRAFRGGSNENWFLHQALFKCHLVDELFFSTSVSTRSFEEANRLATEHRYLLLINARRGFLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8C3</accession>
    <name>A0A0D8X8C3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14055</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="14198" checksum="A5847D8FE6C5F9B4" modified="2015-05-27" version="1">MLAEFRSQHKAAHRSELENERTLLEESSAKGKLLTERIIVLETNLRNAEQELARCRSELERLKVEHNSAADVGAALEEERRKLKAELKEIKEREQRLMGDYSELEEENIALQKTVCCVLYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8K1</accession>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716988">
        <property type="protein sequence ID" value="KJH40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5862731at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="49993" checksum="B51EE823841D419B" modified="2015-05-27" version="1">MFSKLSENMDRICAIYGDGSLFSRSSLPFDAELDELSILCNAPFVQKLSETDARDQLERYALRCHISEREKEQLHKRNRELNDAVEILRTQVVRGQCDIVNNDAVEILRTQVVRGQCDIVNNARVLAKQATDALRALEQTSTAEITKLKQKHALSLAQSSTLQNQLKHTAANLEAKKEELKEINKNYDMLRFERDSLRNHTDYLEQELEQVKNRVHDLVEELKMKEDALKVNREKVNAQDSQICALKEKLKKVESDAKEHVRRRENEITQQMDHYLQETKSIDAERERLAKLKIIEMQQRLKQLEEQKEAAERRAQVAEEKVADYKNNFVHYRGQMEGEAIRAITNGYRNALSIIPSSRKETGLSFDKLFPLKPRSYSENVEPSEDSFKKPSGSHCSRPSSKSVRFIVQLRSFVMQNLNNCVQNTITDYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9T3</accession>
    <name>A0A0D8X9T3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716846">
        <property type="protein sequence ID" value="KJH41350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9T3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="192" mass="22189" checksum="141FDD967647A2CE" modified="2015-05-27" version="1">MRNAFCTYRHHITELAIITNQATQQQKTVSSLDSGSLGFEKQQRPIRWLRINEKGVAKLNLMTNVQSRSARSDNYRPPLLSRSLPYYDKCDVCIFRSSRIGISCPRYDENNTPRNILDKQFLQQFEKDHVYKPLSGCYFTESTVPQRMCQYNTQLSSQDRCSIIQRVVMLALVLFSIAFITTSSVILFISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9Z9</accession>
    <name>A0A0D8X9Z9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Histone deacetylase</fullName>
            <ecNumber evidence="2 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_12607</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 11"/>
    <dbReference type="EMBL" id="KN716829">
        <property type="protein sequence ID" value="KJH41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9Z9"/>
    <dbReference type="STRING" id="29172.A0A0D8X9Z9"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF29">
        <property type="entry name" value="HISTONE DEACETYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="462" mass="52425" checksum="EE03E393DD147D86" modified="2015-05-27" version="1">MLVLYFRILANIGNYYYGQGHVMKPHRIRMTHHLLLNYGIYRDLEVYRPFPATFEEMTRFHSEEYMSFLKCASPDNLKMYNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAAVKLNKRKADITINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGRLYSLNVPLKDGITDDAYQSIFKPVMTKVMERFQPCAVVLQCGADSLNGDRLGPFNLTLRGHGECVKFFRAQNIPLMMVGGGGYTPRNVARCWTYETTLAVDREVPDELPYNDYFEYFGPNYRLHIDPSSATNENSPESLRRIQEAVIQNLEKLAFAPSVQMQPVPEDAMKVLNDSSLGQDMADPDVRLHRSVIDGVTQDSGEFYDGENESDDRRNESNAKRAAESLSQDQIEAKKPKTGDRSFCRCIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA39</accession>
    <name>A0A0D8XA39_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717076">
        <property type="protein sequence ID" value="KJH40632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA39"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="27416" checksum="8591A965D142FD3B" modified="2015-05-27" version="1">MCCPSIQLQPQFSVLCFAPVTSCWCCVLPVAPKNKFPILSVQIFIQDNELTSQNFLNESLVEDIWFASHWMDSSLNSHINLEKRLFLAVVIAAIYLIVEKISTDELTVQHFVQFNDVCNIIRFCNIFAVTTNKWYANGVNLGSMSSGGWCVFELNTVLIRNSTHFSLIAVVLLSDFSNGIGSTRPLVQLEIAKATHHYADMRKPFVALTSHLCLLNTNKHPIMARRNKSEKSRNGKHLCWHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAL1</accession>
    <name>A0A0D8XAL1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MELT/VEPH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716788">
        <property type="protein sequence ID" value="KJH41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAL1"/>
    <dbReference type="OrthoDB" id="5869902at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="228"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39177" checksum="704AD8DE52578C79" modified="2015-05-27" version="1">MPGIRRATNWASAYETTFPANCGPVTTTKLHLLSEEEEKHWKSVDRSDVVLQFVDHRRNKLRRYVSDISSRFPIPIQCTVEGSKSSKHRMIVHFSCQVHNTYCAFHDDYMFAFKTKFAAIWLHLMFLQMQSNSIENDCGVISQSAAPFLTLARCWQCLPARITKDKAFVTLVTSAFPTIKEQDKLYKELEEASFFDCFSLDVPSNRWSCFSCSHPDRVRSFVEDGGSQRVLEGQLKEKKGRWRFLRRWHTKYFTLSSAALTCSSEEADESSAAVPAIDLRSIRSVRSLSRGRKSRKSLRRAFEIFTSDNTSVILKATDEKKAEEWLQYLQIAVAHAKRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAY6</accession>
    <name>A0A0D8XAY6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_12289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KN716770">
        <property type="protein sequence ID" value="KJH41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAY6"/>
    <dbReference type="STRING" id="29172.A0A0D8XAY6"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49143" checksum="382DB842C9445382" modified="2015-05-27" version="1">MAVVGDVELRSVVRVERVGAHSHIRGLGVASNFDPEDVADGMVGQIQARKAAAIIVKMVQTGNIAGRGVLIHGQPGTGKTAIAMGIAKALGQDTPFVSISASEIFSVEMSKSEALMQAFRKAIGVRIKEETEVLEGEVVSIEMDRPATGVGPKVGKLSLKTTDMETIYDLGSKMVDECIKLRICAGDVIQIDKTSGRLSRVGRSATRSHDYDAMGPQTKFVPCPKGEIQTTRETVHTVCLHEIDVINSRSQGFLALFTGDTGEIKSEVREQINKKVAEWREEGKAAIQPGVLFIDEAHLLDLECFSFLNRAMESELSPLLIMATNKERGVVRGTDVTANYCLPPDLVDRLIGIATKPYTNDEIGRILSLRADEEGVRMEAGAINLLKMIVGETSMRYGMQIIAVSNVLRERRKKQMVTKDEISAAYKMFYDTKRSEVYLTENSEKFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBV8</accession>
    <name>A0A0D8XBV8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716708">
        <property type="protein sequence ID" value="KJH42105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBV8"/>
    <dbReference type="STRING" id="29172.A0A0D8XBV8"/>
    <dbReference type="OrthoDB" id="5868031at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="214" mass="24486" checksum="219429E45E8DEB8C" modified="2015-05-27" version="1">MVDSELPRAYANPADSPCSSSSSEEESSSTSSVDSELDESSSTSSSSSEMSRASRRRTTRKRYYRRRRDSTSTSRSRSRSRRVERGKQDRFSKSKLTSQKSKHEGCHESTNSRSTRDGHERGDTKYDRINGTDRLSSNRNTTKRNTRQSYECQCGEKYVTQKTLPSLSKLIEHFQNIHKDSLVICVYCKSVFGKAKAMSDDQWKRLKTHMYGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBY0</accession>
    <name>A0A0D8XBY0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_12788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716872">
        <property type="protein sequence ID" value="KJH41242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBY0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="272"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH41242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="416" mass="48047" checksum="722572DE0EB54A6C" modified="2015-05-27" version="1">MDRGTVLQRAAWFLATHEKTAIESSDPEKPRGLASVSRTIQRTGSQLRRTRLFHLFYIFVLPIYTVIGAWIFKTLDGEHDDRLIEEFNNRCDLSRNVTLDNIRLMCRTGDECFNLMKNYLEKVERCYKNWHLVNRTTTHSMNDFTNALVYAFSVYTTIGYGNMAADTTQCRMATIVYGAFGIPLFFAFVKEEGNLFRNVFIYIYNRISKWRRKHCGCRCGVASKDVLGRPLLHGGLHSKKARFSRKYSTASMLGQKSLSDEQRRVFIAGVLFFILYILLSSFFFSISTEFDYITSVYFLFNSVALIGFGDVFPQDPRTILINAVFIVFGVVLFSMCYFILQEEIRNKAFEASRKARISISKYSHTILQHASRGAWSRRNSPLLEMNPQSAFDRLRKRRQSAPVLTLTVPTDTPREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCP2</accession>
    <name>A0A0D8XCP2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716671">
        <property type="protein sequence ID" value="KJH42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCP2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="59" mass="6576" checksum="68D229238FEF9D39" modified="2015-05-27" version="1">MLLTVKKNISREAFTQQHSDDVDNGYIRSVSGEMSDLDGTQLHHRQGSDPSLRAVLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCU9</accession>
    <name>A0A0D8XCU9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716791">
        <property type="protein sequence ID" value="KJH41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCU9"/>
    <dbReference type="STRING" id="29172.A0A0D8XCU9"/>
    <dbReference type="OrthoDB" id="5772665at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17377" checksum="C5005893D2E4C891" modified="2015-05-27" version="1">MYNLARMFHINLLEFTSCNTTPCLNDGICMEIDGKHRCSCAESFHGPFCEFSSKNWTNDWTITEITLLLVIVFLLTCAVATICCCRNMGFYISIPNKCYKRWEEGEFSDDEDVVITLSHIRNRTIRTSYTTETIVEAEPSCTSSQKSNIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD28</accession>
    <name>A0A0D8XD28_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EDRF1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716654">
        <property type="protein sequence ID" value="KJH42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD28"/>
    <dbReference type="STRING" id="29172.A0A0D8XD28"/>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="857" mass="96881" checksum="A5E0D042DA26A37C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE55</accession>
    <name>A0A0D8XE55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KN716717">
        <property type="protein sequence ID" value="KJH42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE55"/>
    <dbReference type="STRING" id="29172.A0A0D8XE55"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="428" mass="46930" checksum="6893E0A1C4A4C225" modified="2015-05-27" version="1" fragment="single">ARSYHYFGSIAQQWDPIETSVDTNSQEYQQNFFQMQEIVDDLQQKIAKIVEGGGEKARALHKSRGKMLARERVNTLIDPGTPFLELSQLAGYHLYENEEVPAGGIVTGIASVAGRICVIVANDATVKGGTYYPITVKKHLRAQDIARENGLPCIYLVDSGGANLPRQADIFADREHFGRIFYNQVVHNVFLAWYLGVFCFMKSKSCTKYTKVFQATLSGQGIPQLAVVMGSCTAGGAYVPAMSDQAIIVKGNGTVFLGGPPLVRAATGEEISAEELGGADLHCNESGVTDYFAHNEEHALYLARKAVAGMAPSENEMRLVEHCEEPLYSADELFGIVGVNLKKTFEVREVIARIVDGSRFDEFKERYGSTLVTGLARIFGQEVGIIANNGVLFSESALKGAHFIELCCQRKIPLVFLQNITGFMVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEK0</accession>
    <name>A0A0D8XEK0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716600">
        <property type="protein sequence ID" value="KJH43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEK0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEK0"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="309" mass="35242" checksum="E50134A5E6438479" modified="2015-05-27" version="1">MSMLQRRITTGVSRLNGLPSRSPENLQGIMSCPSSPAVKKSFRLVIVGSSQTGKSSLVGRFLDNDFEDRYIPTIENFHRKLYKIKSEVYQLDILDCSGNDPFPAARRLSYLSGDMFLIVSSVDNVDSVVHMINIRKQIIDCKASRGLDGINNTPCIFILNKVDLPEHRWQTTEAEVCDLIRNSTGSNDDLVVCSAATNLNIDKAFGKVFALNKCPKYMNPEMHKKLRNELSADDEVGRRHILRRMRSRFSREHDDLTTYTDLDARRPSLRTDLLTNRTKIPVVHQHHLVSHQTSIRLRRNDDGNRCEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XET9</accession>
    <name>A0A0D8XET9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716690">
        <property type="protein sequence ID" value="KJH42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XET9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor elt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
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        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="GATA TRANSCRIPTION FACTOR END-1"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
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        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="252" mass="28740" checksum="007ADF8F1BD499C8" modified="2015-05-27" version="1">MCEFSEHTLPTDPYSIDKMMTREHNINECHSTSDPYHDFFAKESIHHIMDSHQIHMNASVCSLAATKKLYENEHSSFECNSSSLCEIPYSSSMNVLLYDMPPMRMYPSSSRCDLEVNTTSQLPTVFSIPSTTYLSHSQSPIEYLPNAYSPPPQDPVYQTKSTSQHMSSQNKPKKRIQAVPCHSNSICANCKTTETTLWRRAKTGEIECNACNLYFRKNNTKRPMSLCKDTIMKRNRKPRADTSTTTKHSMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF40</accession>
    <name>A0A0D8XF40_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like Heme/Steroid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716578">
        <property type="protein sequence ID" value="KJH43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF40"/>
    <dbReference type="STRING" id="29172.A0A0D8XF40"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="83" mass="9744" checksum="6F87E927F9207AD7" modified="2015-05-27" version="1">MMAREYSLNEIARHCYVHDLWIIFDNKVYDMTAYLDSHPGGKAMLRQAGKDATIAMKLIQMHNIAWRTIEKKLQDHQIGIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFA9</accession>
    <name>A0A0D8XFA9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716897">
        <property type="protein sequence ID" value="KJH41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFA9"/>
    <dbReference type="OrthoDB" id="5862626at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="291" mass="33247" checksum="0A30FC7228441989" modified="2015-05-27" version="1">MMFMEAAVNSLGKMVDDTTYFIWVENVAKASGNSKAISDVLDITGRLKSSERLRHAFTVFLLECMCALKIDDIIIMALIYANAVNKRMNNPISKPKKKHTPSSSIPDDNIVDSAMNRGKKNSSRESITSRKTSCSLQFRCQTNHSNDGSDNNASFEFHDHHLHQRIHRSKTSCVELSNKSSSDDVHRKTSHSTSSQSTSHHEGDRKLEICKFDLSFDNQHLNHYRGKRRSVSLNRNQWLNQIIEPEKYEDSWISVPYRIALRFIQKDARKSAHICDAACENFHETMFHVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFM8</accession>
    <name>A0A0D8XFM8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716563">
        <property type="protein sequence ID" value="KJH43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFM8"/>
    <dbReference type="OrthoDB" id="5850953at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37700" checksum="72BA24F052E38A24" modified="2015-05-27" version="1">MHNEKQPGAGYNAPYLPRVGPYRSEAQRYDPHSNENKAVHVVQAMHDQVCSKNLNEAKFPLINCNEFDIKNGVPLTVDVPAANNPSQPAQIVFYGNNFVAPQGGAIFLQDIVLEGTISCNDQALDSHPILVGGDFLQKQLDDERLQPIAYTSNSQPTGALKKMDESNEAQTAVKYTIIEFMATNDLSCNFWRSSGKNRWEIGSADRVANPLTGIHSAPDSAQKFLVAPFLNNQASSYTLVSKSLTIPLIEAVFFCFHEYIATYGLVLSVCTDKMDCFYKKNTLILGDAIDQNKRWNIRCIKLPAGEFELRVIAENLGENKGEIGFLPIGLSRDSTGHHSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFY2</accession>
    <name>A0A0D8XFY2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716864">
        <property type="protein sequence ID" value="KJH41266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFY2"/>
    <dbReference type="STRING" id="29172.A0A0D8XFY2"/>
    <dbReference type="OrthoDB" id="5920062at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335599" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="207" mass="23019" checksum="739FABEDAFBBBA51" modified="2015-05-27" version="1">MIFEVLLSASIILLGVNGKDVGCDDVDPKCPEWASEGECTSNAVCGSTSNPGQVVSKVLAANYTGLVYLWADFSFTTPFKFQYEDYPNDMQNVCFKFDDKRLLAVHFIVSDGVKNKERESTTDPFVSGWKVVDVAVKESPYSIEALSDLKKNPFDVQSDNCELCVSLQRNAVYFNTEMLLPALITSLFTIAAVFFQDILSEENRGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGA0</accession>
    <name>A0A0D8XGA0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 54 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716539">
        <property type="protein sequence ID" value="KJH43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGA0"/>
    <dbReference type="STRING" id="29172.A0A0D8XGA0"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="1">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22499" checksum="139468CC527508F4" modified="2015-05-27" version="1">MNLRLRSREAQLSQLHAQAEFGEKENDDNLSWSSFCRGITCNENFILVGTSFGHIIQFQCNSELSISTKKYFKEHSASIVDLATCCYDLITCSGDSSGLIIIWNKNFKGVQVKIATEHPITAMSILRKQIIVGTLRGRIILYSATGGELKAEVEYRHSDELPNCLIMGAQFTNGRGSDIALACFDRNMLFRYRLCRKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHX3</accession>
    <name>A0A0D8XHX3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative biotin--[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Choi Y.J."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716482">
        <property type="protein sequence ID" value="KJH44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKI9"/>
    <dbReference type="OrthoDB" id="5851048at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="450" mass="50991" checksum="B577F7B36C81486A" modified="2015-05-27" version="1" fragment="single">EFFKFSGQDRIRALFANYTLDEPAWICTQLCLGVICVLSSKGSKLLQDLAFSLAATTLMPSLFYLWLDYRWWASSRLSFGNSSPWSQWQTATVLISFCNVGVVMATLVEFMSMHSTSRRLTMDEKTKNFLILIAASFLILSCAIVSLDIYTIWKKLFYRLFHGSEQKTPFLTALTAVFAMAASMSKFTSIALPACTCLSLYSLNSTIFQLISYLYLSANEYFGDQLCELFFPGIARCQLSATKNEAVIHFVQVLLDFFVMVLSSIFCVMSMRISFMITTIEINNNRLESPVRWLGVLMAVCGLTVLVQTLVFFKTSSDVHPMVIVYMALYHLSLAIALTIFPLYQILSAEKLSSKPIIQTTLLILSVVRFVEILTQLDYRGTGDDLSVAWKIHQTADFFALISHFATAMIVIRLMANRCEADTDDLQLFNNPLTTELENDYLQFRLQDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKK7</accession>
    <name>A0A0D8XKK7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716428">
        <property type="protein sequence ID" value="KJH45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKK7"/>
    <dbReference type="STRING" id="29172.A0A0D8XKK7"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000004">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="28100" checksum="A880C57F70DDA952" modified="2015-05-27" version="1">MKLNFANPATGQQKLFEIDDEKKLRMFYDKRISQEVEIDGLGEEWKGYVVRISGGNDKQGFPMKQGVLTNGRVRLLLSKGDSCYRPRKAGERKRKSVRGCIVDANLAVLSLVVVKKGDQDIEGLTDKVLPRRLGPKRATKIRKLFNLSKEDDVTKYVITHEKSRGEGKPPRIIAPKIQRLITPTVIGRRKALLRKKIHQRNKSREEAAAYHKLMTMYAKEVKDEKARRRSSASRSSETDVKKSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKS0</accession>
    <name>A0A0D8XKS0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716608">
        <property type="protein sequence ID" value="KJH42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKS0"/>
    <dbReference type="STRING" id="29172.A0A0D8XKS0"/>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="17507" checksum="1C7D24590A1DAC2D" modified="2015-05-27" version="1">MSLGLPIRVFVYGTLKRGEPNANIITNTPGQYRFISEGRTKLQYPLIVATKYNIPFVLNEPGKGYKIEGEVYEIDDIKLSILDRLEAYPSLYWRQKEKITLPNGDETVAWMYLLRKWRSDIYELATPMMSSYSSKGAHGRAYVPRWVNLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLR1</accession>
    <name>A0A0D8XLR1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KN716406">
        <property type="protein sequence ID" value="KJH45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLR1"/>
    <dbReference type="STRING" id="29172.A0A0D8XLR1"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        </source>
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    <sequence length="106" mass="12972" checksum="304D39868D440E1F" modified="2015-05-27" version="1">MFRFKRERDRRTIIRLPPEEVNDKSAPLIPKKCDNDTTYQEKNRYHSDWLSRDDTLSWKQFIWNDLERQAELAWQWNGPFKLNIFQHQSQIVLVVSRLQTLQMSHL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716441">
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    <sequence length="841" mass="93066" checksum="72D10A067E8B6FE7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNH1</accession>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716416">
        <property type="protein sequence ID" value="KJH45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNH1"/>
    <dbReference type="OrthoDB" id="5870220at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="325" mass="36979" checksum="C14413ED9E1BB0D1" modified="2015-05-27" version="1">MKECNVVDTEFNTYFNSRYSKRVLRRTLVGESVKEFIYDTSLKYLDFVIKKENLPENLFCQQYKVGFNPKLALLPTEVRDDESILEKISTIDFTPNKCTAKSAMVLNDNCEKSRECSPIHTSQPSISNPIRSDAVLVEAISRSSKFAPHTSRKGNNLLQKVACISPALRRAKRTTTSTRKRAKNNRKRVSSSFIENKKGKKINLAFLRNVPIVLSWSRSSLNRCILHDIPNGFWNESASAVLNSYFAISSQITGKVTFMGFDIEQLRNEIHDEQETTLSVFLNCTNECQIACCDNSMVDSGLKEDRRIMAAAKSRNNRLLRGYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNW3</accession>
    <name>A0A0D8XNW3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716364">
        <property type="protein sequence ID" value="KJH46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNW3"/>
    <dbReference type="STRING" id="29172.A0A0D8XNW3"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="308"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="493" mass="56539" checksum="AAEFC23F11741A66" modified="2015-05-27" version="1">MKVRTQTKGSRAKSGTRKSVGQVLSDDNCTSNVRTSRSIVESFRPLSPIHIDSRKRKISSFKCRSSLSPCSVKRRSTRDKAPKMAPECQPSTSSVDGSKYIKDDEKQVSTMTEEKSGSSEFYGEIHEENEDVLNYFIEELENDAFRELEAGLNDNAYHQKDAPPQLTALRCSGIGSPKKVWGLLCRKNDLIRPTNRLLDNHPELTARTRAILVDWIMEVCGSEKQHRETFHLAIDYIDRFLGAFHGIRSYTFQLVGTAALFLASKYEEIYPPKLEEFVAYTDGACTESDVRTFEIIMLKELQWSLSPLTCIHWLSMYMQFLGNKEVSKNDENKHVVDQPFIVPDTLREDFMNMAKVLDLLLLDVATLRFSYRELAAAVLFACYEPHSLVQEVTGYTYSELLKVVEWVEPVVKVCERLRSSGDPIAIFDGIRADDLHNIQTHPEQDFEQIMVDIKKEREQAERNRQKMKVVSMTRRRGPLRSRCTNPDHFTILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPJ9</accession>
    <name>A0A0D8XPJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716391">
        <property type="protein sequence ID" value="KJH45704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPJ9"/>
    <dbReference type="STRING" id="29172.A0A0D8XPJ9"/>
    <dbReference type="OrthoDB" id="5864896at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="249" mass="28239" checksum="4E383754CCFAE7FD" modified="2015-05-27" version="1">MFPSRSFPSAKLWCFVVHNIDLQPRTEQVSGAQILAGQALIFNHNEHKEEIVEVILDTGSDHSFITKKLASHLELEDEDFIKLTIQAFETKPKKKKCGVATLKLQDAYGQKHEINVMKVDNITPPLRRCKLDQVDRDFLDHHNVKFSINPDSSMIRPELLLGCQDSLDLLDDRSKINITLPSGIKLITSRLGYLVTGGHSRHMDTPNESNQTKTTVIDQKSEHEVQTTKSLDAQEFMGPEGQERQLQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRE1</accession>
    <name>A0A0D8XRE1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716316">
        <property type="protein sequence ID" value="KJH47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRE1"/>
    <dbReference type="STRING" id="29172.A0A0D8XRE1"/>
    <dbReference type="OrthoDB" id="5912168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="26978" checksum="0E0491E709591FB9" modified="2015-05-27" version="1">MSDTTKHCSSIDERIQKRSVGGRPAERHEYPWTLVLEGPTQCSAVLISSHHVLTAAHCGADRDYDVPCTGTETNKPYITIGNEKMSIIVATEDSCSLENIGSCTSYGIKTLTIHPDYNPCNGRHDLAVLEITSDISSDKSTPICMPKKDEDIPTRKHGMTAVGFGHNPDHPGVRRMDAVNVTMDGTYADRSLIVTKNDGKSICLKLTWMPSTVLSFLGMQSFFEDVRDSIDWVCEVTGVCPKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRP3</accession>
    <name>A0A0D8XRP3_DICVI</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716312">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRP3"/>
    <dbReference type="STRING" id="29172.A0A0D8XRP3"/>
    <dbReference type="OrthoDB" id="1919692at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="532" mass="61093" checksum="EE88E606E035F4B9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRW1</accession>
    <name>A0A0D8XRW1_DICVI</name>
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        <submittedName>
            <fullName evidence="4">RasGEF domain protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">DICVIV_06699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716316">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="100"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="420" mass="48023" checksum="FDCA42C51608E24A" modified="2015-05-27" version="1">MFAQNADAVNFCREGRDRMFSQLLRLCREWCTSIPHDFRNDHMRTRLNELLGLCSVDQTFKQKATDLQINLRSTLNKLDKYDKAVKNLHKTLSDNKQRPIQSDILERFSMVGVDEILLALADNDLADLGQNRNGPGCSISFYVEWFNRLSSFAATEVLRQLRKKHRVEVIEFLIDVAKECCEIGNFNSLMAIVAGLSLPAVMRLKKTVIEFLIDVAKECCEIGNFNSLMAIVAGLSLPAVMRLKKTHILKLYNNRLYYLSIMEMLIPNLVEYTMSGQRLKNQNLEILQHQLDPSGNFLSYRATMKAAQWRAETVGSTQKIVIPFFVLLIKDLFLLYHSGIRTLPNGHLNYIAFSQISEQLRSVVKWKTANCTFPKNAAVLQYMLISSLYGEKDLLLASFECETAESAVEREQLKKLKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS86</accession>
    <name>A0A0D8XS86_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716310">
        <property type="protein sequence ID" value="KJH47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS86"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="10019" checksum="7021778AE7CADEB9" modified="2015-05-27" version="1">MLEYILIKHFRNTIKNILDEINVADNDSKELKVCCARVADAYQSAIICDTYHHTSQRPTPHHHWAAIEILPYCIMRTTHMKLLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT31</accession>
    <name>A0A0D8XT31_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716297">
        <property type="protein sequence ID" value="KJH47670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT31"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="10558" checksum="EDFD0B41125A5E78" modified="2015-05-27" version="1">MTRCIENDNNRLVQIDRNKLLNFLRILLVMKLMTTIMVQYNIEHYRSELNRCTNVKSNVLFIWLHHFVVSPHSYDFSVVQNYIMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT82</accession>
    <name>A0A0D8XT82_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transthyretin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode transthyretin-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT82"/>
    <dbReference type="OrthoDB" id="5818349at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001534">
        <property type="entry name" value="Transthyretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038479">
        <property type="entry name" value="Transthyretin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700">
        <property type="entry name" value="TRANSTHYRETIN-LIKE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21700:SF3">
        <property type="entry name" value="TRANSTHYRETIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01060">
        <property type="entry name" value="TTR-52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17304" checksum="43B34AE136F9D83C" modified="2015-05-27" version="1">MFFSCSYKYIMKFHSIPLLLIGLFAVPDVFGFFGREQTVGIAGHLTCNHAPASNVTLKLYDEDIIKDSLLSQEELNDGGSFQMLGHKREFSGIEPYLEITHHCGVKRGCQKKETIGIPERFVEKGHKIKSFYDIGTIDLNRSTKSFTIDCPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT88</accession>
    <name>A0A0D8XT88_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 / NOT3 / NOT5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT88"/>
    <dbReference type="STRING" id="29172.A0A0D8XT88"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="151"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="308" mass="33691" checksum="7038B2DBA02AA822" modified="2015-05-27" version="1">MANGKRSNADNSTTLMRGVDASLNNPEFQIQNEDFPALPGSSPGDHPAQAPASLWARIQMTVANDMPMSSTAASDPFGVRPAGETARGIITHPDGEVSNIPPTMLADQFGMAGLVTYLRTVDNPSIVSLALGYDLTTLGLNLNLSERHLYTSFGGPWADNPIRPHELDVKVPDDYLTNAQIRDKLPPVKLNKLSEDVLFYFVYNCPGEVYQLAAACELYQRDWRFHKTDGNWLTRSQYGGVKEQTGSYEKGQYNVFDPLQWRKIPKELKLEYKELEERPKLPAMFGGGGGGGGATAPSMNASAPRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTB8</accession>
    <name>A0A0D8XTB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_06053</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTB8"/>
    <dbReference type="STRING" id="29172.A0A0D8XTB8"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
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        <location>
            <begin position="49"/>
            <end position="452"/>
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            <begin position="736"/>
            <end position="1115"/>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
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        <source>
            <dbReference type="Pfam" id="PF04563"/>
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        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH47858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1117" mass="126667" checksum="8CF5D04EED334584" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTD0</accession>
    <name>A0A0D8XTD0_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="322" mass="36234" checksum="6BC4066DEFA3DCFE" modified="2015-05-27" version="1">MALNKGSIPWVEKYRPQKLEEIVGNEEIIHSLGFFVERGNPPHLIMTGPPGCGKTTAIWAMAREYLGDQMKDAVVELNASDDRGIDVVRNKIKIFCQTKVSLPSNRHKLIILDEADSMTEGAQQALRRIMESYSETTRFALACNQSDKIIEPIQSRCAVLRFHKLTDAQVVYRLQEVCKAENVSFDDEGLNALLFTAQGDMRQALNNLQCTVSAFEYVSAENVFKVCDEPHPQLMANMLTQCAEQNFKDAVAVIHDFYRMGYSPEDIVSNMFRVSKTVPLPEYVRMEFMKEIGICHMRISEGLSSILQLSGLVAKLCAVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTI3</accession>
    <name>A0A0D8XTI3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XTI3"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000471">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing protein"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
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    </dbReference>
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        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
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            <end position="641"/>
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        <location>
            <begin position="19"/>
            <end position="40"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="642" mass="73075" checksum="C40418F64203D601" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTP6</accession>
    <name>A0A0D8XTP6_DICVI</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_06018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716289">
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        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="343" mass="38817" checksum="4BA3B7E78E893473" modified="2015-05-27" version="1">MKVVWKSCIDSMKEAVCMTFNKLSQGVKFQDIADLHNGLLERFSPRCIHRPLQYILVFILFHIYLLYAVVFGITKFLILHTKIKGARVFPIYSSITSYKEKVIVFLTSIFLWHWFSTSVLGISIGWQYLSTWAINFRPKITIKPQLKLVSSTDSCHSNASKVSLSMEEVDANVDVYLSPEQKELASVMNGIKTVSSTASFASDLVSSIAASVTQTDSPDSLLTWSSSVGQDSDEVDLDAEMEQANCSTEHLNLREGSNWSKQNEISEEIEHKKPRMSFRQVAKEVLTRISIGPDGVRSRIPRPEALERFKARNAIANLKLRQYFLRRNNSPDVVYSNLEGSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTR1</accession>
    <name>A0A0D8XTR1_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_08221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716389">
        <property type="protein sequence ID" value="KJH45746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BAR_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="193"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34697" checksum="7E52B17E38AC551D" modified="2015-05-27" version="1">MIGSGDMPSVIFTLSTRHTKLTHLYFIFVGNNFEKPFNHIDRIDYLQSPSKAKSSTTTVTSSKTCSADTIPSYPAKSKSGKGVLLTSTVSYQNISLKSLITAESGSKTKQAIRKFLFRVKESIGLVKKTEISKHFSDSLEHLDHYKLCLDSVAEAVCHAIQDNPKYRVENRKNQIKLYEMRGMEHREYIRRAIRTMNNIRSFIQNDYWVIGARRTELDTLRREMDFAKSELKAAKDEKMIAAKDHLYKLAVAAFQEKTKQLSIMLDDLSNSKASHIADLEDLMHCIRKYHERIAHLSKEVEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU35</accession>
    <name>A0A0D8XU35_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716380">
        <property type="protein sequence ID" value="KJH45886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU35"/>
    <dbReference type="STRING" id="29172.A0A0D8XU35"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU95</accession>
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        <lineage>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
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        <text evidence="13">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
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        <location>
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        <ligand>
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            <label>2</label>
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        <ligand>
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            <label>2</label>
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        </source>
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    <sequence length="412" mass="47210" checksum="D598B8160DDEDCB3" modified="2015-05-27" version="1">MLFLDDFLEMLDELPAELREKCTEMRHIDMQVEAGLAQNRLALMEFFDRGGQLSEEQRQRRYKELQKEYDRLRILGEMKVSLAERMQEVLETYMQYLDKEKTHFKYELEADNPGITEVIETRFANYCESLIALRKERKRKLMNGSVDIPDESLSKLPRVLSHGNSSSNQVRSEITTFVEDEPISPMVSGAGTVKNKKSITEERRTTPILLKTSLNSPSVQSTNVASPPVSEKSWTPLSNPPALDELIPCSTATPTNTLSSTQLTPTTASTMPAFVGPESRHGRPRKQVLFVLLTTRVQEMFKEAVQRQRHHYHKNNDATHITDFHNDGDCDISEEEDETDDSKRKWCFCNEKSYGDMVACDNKACPYQWFHYPCVNITSTPKGRWYCPHCTEERGKRSESADFSSVSTANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUI8</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF73">
        <property type="entry name" value="KAZACHOC, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="7">
        <location>
            <begin position="206"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35885" checksum="9BF5538DFCD343D5" modified="2015-05-27" version="1">MWTWGCLGATIGAGMQSLTGAPRLLQAIASDDVIPFLKPFRKMDNRGEPIRAILVTVLICWLGILIAVIENITALITQFFLMCYMGVNTACALQSLLKSPGWRPSFRYFHCVLSLSMLGAFLCVAVMFISAWHFALIAIFIGAAVYKYIEYAGAEKEWGDGIRGLGLSAARFALLNLDNKPQHSRNWRPQLLVLLDNTDSVSTSGMLSFVSQLKAGKGLTLVALCTEGEFSKDADDAAKLDCLMKKNKIKGFGDVLVTERITEGVSCLVQTSGLGALRHNTVMISWPEQWNTEHSWHVGHRFVSALRACSAANRIPISQTIRMSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUV5</accession>
    <name>A0A0D8XUV5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_06385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716303">
        <property type="protein sequence ID" value="KJH47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUV5"/>
    <dbReference type="STRING" id="29172.A0A0D8XUV5"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="20143" checksum="955934C557166F5C" modified="2015-05-27" version="1">MVLRRTMFFHLSMEHEVCLHPKYFGANLNETIKMKLFAEVEGTCTGKFGFVIAVTTIDTIGHGLIQPGRGFVIYPVKYKAIVFRPFKGQVVDAVVNQVNKVGIFCDIGPLSCFISRHCIPPDMEFDPNSNPPCYKTEDETSIIKQDDEIRVKLIGTRVDASDIFAIGTLMDDFLGLCSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUV7</accession>
    <name>A0A0D8XUV7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUV7"/>
    <dbReference type="STRING" id="29172.A0A0D8XUV7"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="20047" checksum="36A89AA0FE7BA4F3" modified="2015-05-27" version="1">MPLTKKHQLTIEKSPAYFHSSTVAERIRALNPAMKIIIVVRNPVTRAISDYTQASSKKKILCRLPTFEDMAVGDCAPWVKINCSKKIDGVNVGWGAIRIGLYHLHMKRWLDNFPLHQIHIVDGERLVSNPALEVRQTERFLGLNPGASSSLIQRFDLHNDTDKISIFSGEEKRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVX1</accession>
    <name>A0A0D8XVX1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:sulfate symporter transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVX1"/>
    <dbReference type="STRING" id="29172.A0A0D8XVX1"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
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        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF77">
        <property type="entry name" value="PROTEIN CBG18085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335996" evidence="8">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="410" mass="46532" checksum="B094E1D3ACFA3BA1" modified="2015-05-27" version="1">MAGFMMITSFISLWISDTACAALMSPIAVALLETIMLHKMHYATVNKNDIAMRDYGQKGMRNLQMFDVDRCTRVIDRWFYPNENTGISYLSWMAIAVPPMIGYMVSSWMIVQIQFLGFRHISRIFMPSREEDKIDEDYAHKAVLAAYNDLGPITFAEKSTLVIFLLTVFSWITSDPKVINGWATFMKSGYVTDTCSGMLAVFMLFVWPREMPDFVFLRSESEQLRPSVRREALLTWDAVRRRFPWSVILLLGAGFAISKSVKESGLSSLIACNLEHVFFGFPLLFMQICISFISVVLTEFSTNSATASIIIPIAFNIAESVRAHPLYFSIPATIGPSFSFMLPMATPPNAIVYESGMLRMIDMVTSGIFLNVFCIAITVLNMNTWVYWLFSMNNYPDYALHHNNTSPCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWC8</accession>
    <name>A0A0D8XWC8_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWC8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10402" checksum="181AB83BC2D839C2" modified="2015-05-27" version="1">MQIMTRFSGLYTGVYELQALACFESLGKQGGKSYEKCIDACASAPFLHMGFMENYPKSSFKPVTDLGTELIYNEPDLFYKRIESSIVVCWCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX06</accession>
    <name>A0A0D8XX06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716272">
        <property type="protein sequence ID" value="KJH48299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX06"/>
    <dbReference type="STRING" id="29172.A0A0D8XX06"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18364" checksum="115490FCF12F6CB6" modified="2015-05-27" version="1">MNYTNDKISIIKQMLAYGNIFKIVGDKHHRLLQYNQISTAIAVGMLLSAIQYVGLSTVVTSPLNVGSNISRILRRPSNEWCFCVCSVLTEMQSLKARVHQSIFKQLTYLVYFYFAQTLYSTMIRKWITRRGNYWRACHAIKKTHLLERSFDMKTCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX39</accession>
    <name>A0A0D8XX39_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_05575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX39"/>
    <dbReference type="STRING" id="29172.A0A0D8XX39"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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    <accession>A0A0D8XXC1</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="16007" checksum="878168E5EB79BE16" modified="2015-05-27" version="1">MCSDPTWKTILAEDCPKTCGLCNQNANCVDTIPGCDRDPTICGNAALQDFVKVNRSSLSNGMRLIAREHVDSVKALLQALLSVLNVDQIQASLIGYVMVFAPALFIPILKEGNTVADHVDCAEKMNNQSASVSQEVHLFINKKEKES</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="36519" checksum="00EAB151FE7FD55F" modified="2015-05-27" version="1">MADAASLTGFQDDRDALEDPLEELLARQRKEKKALKEKVLSMKKSAKSGNRQKQKETNAEIEKLEHDLADRHEKELRGLRIQSPAYHEEPSNDSVIREPSRISMEELEHSFYKQVTISSRTKKKQMKHNDAIRRMQEAIQIDRENAATSLRVTEMIAIRKILDERGLDLVEIAPDGDCLYNAVADQIRRTRGYEQATGKDMRRRAAKYIREHKDDFIPFLVNEDDESLSDIEFEKYCHGVENESKDGGVWGGEPELNALSQSLERPIELIQPMGPPVIFGEEYKTKQLIVVYQRHAYQLGAHYNSTTSKKFKETQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYE6</accession>
    <name>A0A0D8XYE6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_05094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">HannoverDv2000</strain>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XYE6"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:potassium ion leak channel activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="K_chnl_dom"/>
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        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZR4</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KJH47816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="72" mass="7918" checksum="196192C2D282562E" modified="2015-05-27" version="1">MCYPFQNCKSLNVSVVLLCTIQGHLLPNLEPITAGLTWLMWPESCPPNGGILADEMEYTETLSDLFSNADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0U9</accession>
    <name>A0A0D8Y0U9_DICVI</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716275">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="20457" checksum="485105D12FD6EDA0" modified="2015-05-27" version="1">MLQRIFLFILYCLAIIRLIDTQRGGMVAGRRGFRGVGRGGYGMGRRRNGGRGDDNGRYGGGNSRSGRGGFGRGGFGRRGAGRSGFGRGRPGRRGFGRGGFGNGYGRGGFGNGGYGRGGIGNGGYGGGGFGNGGYGRGDFRNGGYGDNGRYRTVASLGRLIGFVSSVASGGHSGYGHNIGYADYHGDYHTGSEYYDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y124</accession>
    <name>A0A0D8Y124_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="11258" checksum="80339D0BAE0F6930" modified="2015-05-27" version="1">MLSCPGAAPLFMFSITACTQFGEIDGGIVPTLRLLREFWNEYHLSQISVSQLKELLSWHTYHSISKRNIAIDQRYLLFIEFAAAKDDGGDLFFEDKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y163</accession>
    <name>A0A0D8Y163_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Aspartate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">DICVIV_05577</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716271">
        <property type="protein sequence ID" value="KJH48336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873:SF6">
        <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873">
        <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="Asp_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartate dehydrogenase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19194" checksum="C33AB1B17B2AAC4D" modified="2015-05-27" version="1">MTKHPSSFKLESPLREINDIVKANNSDAVALYEGPVRALCQLAPNNVNTMAGGAIAAHNLGFDGVIAKLKQMNFCLRMSDWHIVEVEAVGPDGFSVTTKRKNPAKPGAVTGQLTYHSFLASIKGEIALKSINPCGTRYAMTSEFQNRSINRLDFTYADEALNLLKIMLELRVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y176</accession>
    <name>A0A0D8Y176_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">DOMON domain protein</fullName>
        </recommendedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716205">
        <property type="protein sequence ID" value="KJH50440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5905679at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336308" description="DOMON domain protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24740" checksum="15EB990360EB003A" modified="2015-05-27" version="1">MQILELSGIGINLMWIRFITILLHGSVDSEGGTVYIGYTITRCSGEEYGEDLAVYDYATIFRHNNEIQHVRHRVNWLGSRSIGWKMYFTISDLKFIEGDIIVYLSVFTGPKQRVNDNPEYMKFIYGADRRFIFDSAKSGTGLDFGNFYNRNPISIESVYVIFTDVNKTFSFDSKGCHDSATWIANEGLYAFDLKKHEMYPVYYDVLDDPYIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y188</accession>
    <name>A0A0D8Y188_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716270">
        <property type="protein sequence ID" value="KJH48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y188"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9181" checksum="89E9EEBA3B088FED" modified="2015-05-27" version="1">MTRENNGRQYLDEKTSQYCAFVSVQQHDSGSFPVDLKLCIPTVGVLRADYAVGGVSPGVIDTLLPLAFSLIESVLLSSGSPFISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1N2</accession>
    <name>A0A0D8Y1N2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_03793</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716216">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10851" checksum="A9CED510BB82AED7" modified="2015-05-27" version="1">MPYGSPAPQPRTDIHRYVILMRINVPKPSSRAKFNVKQFIEKHKLGVLQAISKLMHFFSTTDHKYTVKYWYNNLFFIITLTYLLMRFPTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1W7</accession>
    <name>A0A0D8Y1W7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1W7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9968" checksum="E378F67FB70B945F" modified="2015-05-27" version="1">MPGFPKISQAGYRCVSLYDDMICKQLYGPDFHYLYNGCTNITKTRRFATVAQIYFHQFATGNLTQNTTFHINIFKVDVSYRKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2H8</accession>
    <name>A0A0D8Y2H8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NLE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2H8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2H8"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="426" mass="47322" checksum="70D635642E62A3F3" modified="2015-05-27" version="1">MDDNAVGQISVRFIGENGDELGGTGILLPTSVTCSQLQILCNQLLGSSEDPVPISFFTENGVEIVDSIEKNINNIDFEKTLCLLYHPQAVFRVEPVTRCSSSMPGHTEPVISAQFSPDGRGLSSGSGDATVRIWDIDTELPLYTCEGHKNWVLCISWSFDAKKVASACKNGQIMIWDADTGSQIGKTLIKHKQWITQLAWEPLHKDPSCRYLASAGKDGNIHIWDTIQGYVVRSLNGHTASVTCIRWGGEGLIYSGSQDRTVKVWRAKDGIICRNLVGHAHWINTLALNTDYVLRTSCFDPSVGCDRPAKEQYQEIAHRRYEDTLRICGGERGHVNAVYQVSWSADSRLLVSGSADSTLKVWEVRNRRLYFDLPGHGDEVYTVDWSPEGTKLFILSAYHTIHLPKLLFDLVSGSRSVTCAKRGKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2Y8</accession>
    <name>A0A0D8Y2Y8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2Y8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2Y8"/>
    <dbReference type="OrthoDB" id="14045at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022470">
        <property type="entry name" value="PTPS_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022469">
        <property type="entry name" value="PTPS_His_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00039">
        <property type="entry name" value="6PTHBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00987">
        <property type="entry name" value="PTPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00988">
        <property type="entry name" value="PTPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="16309" checksum="FE9893A3EA3E43CE" modified="2015-05-27" version="1">MVRGVVTMERVETFSAAHRLHSSQLSPEENQNIYGKCNNPNGHGHNYVWKVKLRGIPDPVTGMVYDLNELKKEMKIVLDTVDHKNLDKDVEWFQHHVSTTENVAIYLWEKLRVQMSKPKVLYKVTVEETPKNIFTYKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y336</accession>
    <name>A0A0D8Y336_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_04885</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
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            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF19 subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KN716249">
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
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    <dbReference type="InterPro" id="IPR001841">
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="395"/>
        </location>
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    <feature type="domain" description="RING-type" evidence="17">
        <location>
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            <end position="63"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="659"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="121"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="645"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061087"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="806" mass="88649" checksum="72FDE6D3E59271EF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y396</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49051.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="53399" checksum="D41DF67DA7E34564" modified="2015-05-27" version="1">MEFVHPQMLECLICRLTYQLHKPYNVCRGIRHLKSRHPEIMPEFNGEPLRRYRKTGTALRLDDDPNIPRRRRDTQLHVNDDSDLLARMKAQYPGSFDKVQTIYGAAGEPMYVLMSKSDETEEVIKENMKLISNASAPQHGKNKQRAENNGEHLALDEVKPRQEVVFELSYDYDNLDAHGKPRKHLVRVTPGVQNKLSLNSDSRPRYLVRNEGHSNTAAEVEQSEPNEVYFGDAEHGDENSTEESAVIFGDVLFIDADGNEIIQRTTALPDGTIQQQYLGQAEDGSLYVLSDIVSTGLHPYADSVEEVFEEMISDDVPQQELILDDYESHLNNIPSHRHQVNNHSGQSVETEVQQKDFDSKSSSLVAHTYNGGETIVVEEYCDEEDRLRQKYGREIVISGDARYDEDETVLNEEVFRSGSVVKQEELVYDADENTTKQQFDRNVSDGEQLSIVTPSTNVLPPSTTDINNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3C0</accession>
    <name>A0A0D8Y3C0_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="25695" checksum="AE12D012A2B79C83" modified="2015-05-27" version="1">MVNCVVSQQILQSYVVDIDPQLEPFDVPLSDLEKDVEPTTTLSEQCSRFLNHYRQIAFWKYSGLPIGAQKALTKCYTHCKETDPVCVNACECLHLQWVMNYECFPGIRAPAGPNCQRNVMLSIVLSLEEKKLMTSTIAGNYRTFNRPRQHGVSFYRGTNTVLVDWPEGKISSASTVDVPAVGVNVIYNAVDIGFPNPRRTLHDLTKDNPDPLNPGTGRKKSAVSMMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3E8</accession>
    <name>A0A0D8Y3E8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="427" mass="48929" checksum="5BF7E79329F2DD88" modified="2015-05-27" version="1">MDLLDSISAMITNTENHKSSGKPKKTNVAKSDTAVSLSKSVVSREQSLQNKKEPVLSKGRNDLITSMNLPVEMNALNIDLSNAPEYVSRYHIDIKKVMQKKKKDATRGPKQDVSTQLRRRALFSVFRQLVTERAEIFGEDSTKHVYDLGNTFYSIGCRIKEQDGDIVLDMKPVFLKRLKQNESETSLREAARFLDVLTSQSLYHSDSHIFENKFFEGSTDNDIKLGEGKCIKSGFEKSIRVVEGGNDMPASLVLQVDRLVVTTTHMNRNRRFFIYGIVENNARNQFFQTTEGSISVEQYFQEKYKLALRYPLLPLVTERQGSTGINFYPLEVLYIEPGQRVENKKLAGRLTEKVIQQTRMLPQEMRNHNIRQLVQANLMNEENQYLNSFGVGIISPSRCFFLIPFPISLFKHSLRIVMYCIFGGRKQ</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50574.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="368" mass="40325" checksum="20F7C90CA5D6B992" modified="2015-05-27" version="1">MEAAGAILLAITNVPEACYWVETSNGIYGQTKNPYDLRRSVGGSSGGEGALISSAGSVIGIGSDIGGSIRIPAFMNGIFGMINTPGVISQDGHVIVAKGYQKKMLRIGPMCRYVEDIPLLVEVMGGDQVVSLNLRDAVDFGKIRLFYMEGIQNTFTIETLSDDMRSSLMKAVAHFEQKYDVEGIRIDLPLMSKAVEMLFVSMQIEGEPKCSQYLKSLKADKGSLNWFSELPKFLTGRSVHTLGALFISFFESVDNRTKNEKTELLRLRNRLTRQIEEILGDNGILLFPSWPHTAPYHHHNVFTPFDVAYTSVFSALALPVIQCPMGLNANGLPLGIQIIGTPNSDRLLIAAAKEISDRFGGWIQASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3H6</accession>
    <name>A0A0D8Y3H6_DICVI</name>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
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        <location>
            <begin position="88"/>
            <end position="132"/>
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    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="37719" checksum="E2F6E154E61095A6" modified="2015-05-27" version="1">MNESNRAIEPGRSRKGIKRNANLTGGLLDLVNNPRKSRRSKRTARGFYDTSSKLNAPLWIRSIFFLISWMADENYLPRPPSDDDLRNAIERLAVFVAKNGPEFEKMTMEKQEGNPKFAFLYGGPFNEYYRFCVEREVQNLHGGPPIHQGNGCIGPPAPESDFIRRMNVQKEQLKQQITDSERNLKAHLDSIPAMKEAQVAQAVVLSESQKMSQILANVNFDVAPLGTILDQLNSGKCSKDLVSTSRKWIFEHCQTDQLREVVLTYLLSSQRKRLDSQTQMLSRYVPQMYAFTAELSTDGMMQQKLDKLIGVWEGHNYFNDHCFKCNFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3L1</accession>
    <name>A0A0D8Y3L1_DICVI</name>
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            <fullName evidence="4">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3L1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3L1"/>
    <dbReference type="OrthoDB" id="5815718at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15873" checksum="964C12ED89272A0E" modified="2015-05-27" version="1">MDTTIRDKLGIIPDHVKFGAQSAAVFSRQSEDFMKPIWSTVDELLINGTNVIVYNGNQDLICDSIGTEMWMDRLTWTGMKSFKTMKKVKFGTKSFPLAGFMKRYSNLSFYLILRGGHMVPHDTPEAALKVVQQILIDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Z7</accession>
    <name>A0A0D8Y3Z7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein UNC80 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Z7"/>
    <dbReference type="OrthoDB" id="5811172at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="32852" checksum="52CE97F032E4509F" modified="2015-05-27" version="1">MHYVRAQCEGWDKALGMALSLTWILAPNVQGLYFKDLKQTLKKEQCDQALMITANVPSAKKIIVHGPDSSMGGIPSQFPVHEDTQFQQILRYLPRSTLFSVIHNNYILKFYINDSLEFFNIDENNINCYFLTDTKSGLIHLPSSYVRDYYFFHRSFYPQLTLVKLDVDEAQLRMKQTVFAQRFIEVGKVLLTHNILKYSPQHVIAQRVFFLHDELTHLPSFPRKSLETCFGMFHGEMGEQLKAMEAMHKFTWAKLMSDMFEKMENAFMFADLHLFINVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y439</accession>
    <name>A0A0D8Y439_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ammonium transporter Rh type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y439"/>
    <dbReference type="STRING" id="29172.A0A0D8Y439"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000012">
        <property type="entry name" value="Rh type C glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="60"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="489" mass="54002" checksum="42F29F1948C5843D" modified="2015-05-27" version="1">MEWCASRCCYFRDPRMTSSSQKHQFTIVVVVLQAIFMILFGLFAKYDENTMPNGSDDLSSMSSKYPMFQDTHVMIFIGFGFLMTFLKRYGFSAVSINMLLACFTIEWGMIVRGVLSEEFHTNGRFIIGIDQLLTADFAAAVVLITMGAMLGKLTPIQYLIMTLIETPIAIFIEHHVVHTFHVNDIGGSIVVHTFGAYFGLACSKTFGNKRQRDHENEGSIYHSDIYAMIGAIFLWVFWPSFNAVMAEPADARQRAVCNTFLSLCACTITTFLASQATDHHKKFDMVHIANSTLAGGVAIGTIANVVLHPLHALLIGVIAGLLSVVGYKYITPLLTSKLGIHDTCGVNNLHGMPGVLAGLLSAILVMVYDPLDYGKSLNLIYPAMRSESNADGISASSQALNQLIGLALVLVSSLTSGLLTGLLLKLDMLNQVRENEFYADGDYFETPSDYDFTTQVISRIDHIEISEHTHLTHDEIKMVDDVPSDRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4C3</accession>
    <name>A0A0D8Y4C3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_02999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4C3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4C3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
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            <end position="238"/>
        </location>
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        <location>
            <begin position="84"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="30514" checksum="D40714A59675B7CE" modified="2015-05-27" version="1">MESGNLLMLADIAKLDHEARPFQSEIGENVVDVLSSLATDAFDHCYLPSNDFERLVNSTHDYYYRVEQWDLDDQEHSYAFQVPSASTDGDQGPSIFGNSENTSNPSTSYMNGVILNPHECKWEGCFVSFESIEELQKHAEDHLHVDSRFCEWQGCNKRSNRYAHRYLLSRHLRSHTGSTPFTCEHCGSQFTTKERMRLHVRAIHTPEVKYKCDVCNQFFKTTSERRHHVTRLHMKERLRCSFCGRLYAGSSVLNRHVKVCKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4G8</accession>
    <name>A0A0D8Y4G8_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:actin cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="438" mass="50883" checksum="2BD1E7A66BB263FB" modified="2015-05-27" version="1">MFREAVFESSSLTALRKSLAVAEQDARKKQEEMEELQSQLVNQDYEQQVAAVQPRLITMLRVQLAAISNINKLRILDSTLSIDEDIEELMQMLENVNDGDLNDVQKILEDTTVLYDQISRGITARSQSDSWTMTEEPEGRAFFTDEEDTKEENEWEAEMTAIQNTHQSEIETMQHNYERQLKTMRERIEHEETRRRKLQEELVQITTRNDQSLTTVKASFEEMLEEQRSGFQEEMEQLRKDHQKELDEEKAATRLALEAVRRAHEEELSRQQRKKYAMLEQMREELTTLSAAYSAKCVENAQLDERLSALMEQRSREGDSTDVQRLQHDLSVRDSQVAELQRRIAAYERRGGDPSAAASDRGEVCSEVQCFEKTSSAVKYRKMNKNRRSDTRFHSNPVISIVEGASECLADEVRRSLAVPVSERRKFFETIAEYSTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4I8</accession>
    <name>A0A0D8Y4I8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FERM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716179">
        <property type="protein sequence ID" value="KJH51635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y4I8"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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    </dbReference>
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        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="32460" checksum="E0DD7EE00D38E8A4" modified="2015-05-27" version="1">MMKSSTAYGKAKEYGLMRIVDDPTKCAWLANGYSLEHYLIRHQDTVEYRRKIRLLKVRMLDGSVKTIPIDESHPVGQLMVGVCTKIGISNYEEYSLVRETESDGRGSLVNLKDERTRTIDGEQRKGMMGTLGRKKEQKLEQLRQKLHTDEELAWVDHSKTLREQGIGEDETLLLRRKYFFSDTNVDSRDPVQLNLLYVQCRDGVLRSLHPVTREIACELGALQCQIEYGDFPENKPKFYIDFSLDDAFVDTADVVVERHCRTGCIMIFMDHYEHQHSCTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4M9</accession>
    <name>A0A0D8Y4M9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 15">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_04360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Golgi apparatus membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 15"/>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4M9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4M9"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000147">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF30">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with galactose moiety of substrate glycoprotein" evidence="14">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH49526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="32818" checksum="AA340F40CFBF4CFB" modified="2015-05-27" version="1">MVKLSRKNRKVLIFATLIITFTIILYIIGTMPNVPPLDPLIIVITPTYKRPARLADMTRFANTLRLVPYVHWIVIEDAIETFPYVENILRRSTHAYTYFALRSPKGYPNRGWYQRTQALQFLRTHSVSVMGKHENAVVFFGDDDNSYDTRLFTDYIRHVKKLGMWAVGLVGGSPVESPRVVNGTVVGYSVHWGKERKFAVDMTGFAVNINEILRTNVGFGKSCPSGLTAPEPCFLEKMGFVQTDIEPFGFDDDGKKLNREVLVWHTRTVNQDFTKEKYDVNGFLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Y8</accession>
    <name>A0A0D8Y4Y8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Y8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="249" mass="29034" checksum="05390D25DC16146F" modified="2015-05-27" version="1">MRNNKDISYLRDVSSDQNETYACVEFTWTSSYKSSEFCDTLNEARYGHLAGNDIVSLPNQIKGCTRKYNRTLCYCNRKLYNCTGSKWIEELMTETTQCPNWSSSYIYHNSGSDYWIKFVNADLMRSLDTVPPNGCYELKKVSDEILRESYDSFIFDHHASVTEIYSSQKQEIIYGSSTEILMLVWISSLIYLFIIMVLCMLLSNDKLWQNNKAHQHYFCCFIVYIYCLRSGLTNALLKLVNKLSTVIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5I2</accession>
    <name>A0A0D8Y5I2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5I2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5I2"/>
    <dbReference type="OrthoDB" id="408912at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047756">
        <property type="term" value="F:chondroitin 4-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902884">
        <property type="term" value="P:positive regulation of response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007669">
        <property type="entry name" value="Chst-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900:SF5">
        <property type="entry name" value="PROTEIN CBG14245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22900">
        <property type="entry name" value="PROTEIN CBG14245-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="193" mass="22734" checksum="83EF799BC0F1F2EE" modified="2015-05-27" version="1">MLTNLRFRFVGFSRFLFVVFLIVYTTKWQKTFDEIEQSLLEARFLANETLNTYVLQQIGPTEWKRSRSTFFRLCPSVSNCELVPPFIHYESRQMIAPSYGVATCVIYKNMSTILTAIMCYLYDALTYRRQVKDLTHDTYNVRFCKGKNEFNSIRSLASFRNSTTGMKLTWLNILVSRNPLERFISGFINKCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5S9</accession>
    <name>A0A0D8Y5S9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium-dependent noradrenaline transporter domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_02457</name>
    </gene>
    <organism evidence="15 16">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <location>
            <begin position="117"/>
            <end position="132"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="KJH52853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15258" checksum="03647BE17A67CC5B" modified="2015-05-27" version="1">MVLKSPTDVVILDERFEFRRITLVRINESVDYAEQRGVLRGCVDRLLLFGLDDDVRSILSSNGNQQVCRETNRKILRLYPLSGDSDLVTLCSCIGEQCNDQDMLLAINSSDGDRRRILVHFITLFMIFAIIYL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="606" mass="66927" checksum="44FE624B03DB024A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
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        </alternativeName>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL13 family.</text>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24234" checksum="1AE809362A996A60" modified="2015-05-27" version="1">MGLYNKPIVIDGKDHLLGRLASIVAKQLLQGEKVVVLRCEEIAISGNFHRSKLKYLSFLRKRCNINPARGAFHFRSPGKIFWRTVRGMLPHKTPHGNLALKNLRVYEGVPTAYYRVKKMNVPMANRHLCLKPRRKHCTVGRLSHEVGWKYRDVVRKLEAKRKIKGAAYYEKKKQSDKLYEQTWKTVQAKKNAAAKIAPYQEIIESYGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9M8</accession>
    <name>A0A0D8Y9M8_DICVI</name>
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        <submittedName>
            <fullName evidence="9">LIM domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">DICVIV_02550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716187">
        <property type="protein sequence ID" value="KJH51271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y9M8"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09414">
        <property type="entry name" value="LIM1_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="17104" checksum="2F75AF499F335421" modified="2015-05-27" version="1">MSQLPNHIVPRINSNGEKYREKQLLTQLPRQDLSVAYCRHLGSNTERKVYEEFINARNEIALDIGYVSPNIPKSMECHKCSGILERNEMAVIAPKLGESTGWHPACFTCSTCEQLLVDLTYCVKDDQIYCERHYAELHKPRCSACDEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Q5</accession>
    <name>A0A0D8Y9Q5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Q5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9Q5"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="123"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="25803" checksum="21FFF0A26CF4E5DD" modified="2015-05-27" version="1">MLRKIFNGAVYLQVPRLFECPSPCSVPSNSSHSSYTSATSSGDTYRRISMNSYGSSLTDNTDSTFEIDSRRSSAWSTLRNAVLEVGSGQKGPLNVTIDGTCGTSQKRTSAISRGKLRRIATQVTRAIRRKRRESMAIRRESRATRVVAAILIAFLICWFPYFCISVIRGIGMGFMMDINVQLHLKLYMLTSWLGYAHSCFNPVIYMCLNTNFRSTIRLFIHRTRKCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBI5</accession>
    <name>A0A0D8YBI5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_00322</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBI5"/>
    <dbReference type="STRING" id="29172.A0A0D8YBI5"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336545" description="Glutaminyl-peptide cyclotransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="105"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="354" mass="40239" checksum="AEC0553CEC6304C7" modified="2015-05-27" version="1">MQAVALLLISFLFSTTAWGQWRTNQRSHELSRLPLNSTFRLCRDFMDPDGFQRILSPLLVPRVVGTVQHRQVGQYIKNFFDLLGWTTEWDIFQDNTPLGKRIFRNLIVTYEVNAPRRLVLACHYDSKILPGSISIWEKSDCFYRQVMIGATDSAVPCAMMMDIAKSLTPYLYGRAAADVALQLIFFDGEEAFVEWSESDSTYGSRHLASKWEKTWYPSTTGANFELSKEIDRIDVLILLDLLGARNPTISNSVGMGADRLYSHLPSIEQNLRKIGCIGAVPNVFQAVISRNAVEDDHIPFLKRGVPILHLITVPFPRVWHTAFDNKDALHYPTIYHLTSILRVFVAQYLGVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCV9</accession>
    <name>A0A0D8YCV9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_01398</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCV9"/>
    <dbReference type="STRING" id="29172.A0A0D8YCV9"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="74"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="385" mass="44674" checksum="0472FE33E459D5BD" modified="2015-05-27" version="1">MSTLLLILETCVFIIIIYLVRYALRPCNRIRKLGDVGLSLGDPQLKGVYRERQINRLIKLRRLGELPPVYPNGWYCIAESDQVKPKSIKEVTVFGQFLTLLRSESGEVHLIDSYCPHLGANFNVGGKVVDNNCVQCPFHGWIFSAENGKCVRIPYDDGSIPEQAKVTVWPVLERNQHIYVWYHCDGNDPEWEIPEFDEITSNIWKYGGNNLLNIDLDNTKPFIRHVWNGKWTPKSGDEAHVSIMYLDQYMTIGSYKIPLTSTRLKAEQHGPGIVHMLFDFGILGRGVVLQHVTPQEPLLQLVRFKMFSTVPSWFSKFFLISEATQFERDIFIWSNKKFIKNPLVVRNDGPIQKHRRWYSQFYKENSPRLLPNGEISNQPRSIYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD72</accession>
    <name>A0A0D8YD72_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD72"/>
    <dbReference type="STRING" id="29172.A0A0D8YD72"/>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="270" mass="32159" checksum="42CBECAD59894351" modified="2015-05-27" version="1">MLVFLDFRMNSLCFLTSKLSISFFPSRAISSTSTLYSVFMKKQRKLIQKEMRKRRRLEKEIRQMLKHSKKPKPVDELLLDVKSAKNKVERYRENVVLTEDQIDERAIALKVCSFCLISDSFMKDLSAIKLYSSYRSDDLPYQFIQYSAHYWFLNKNYKACCVREKIFINRVENNEFHKSWAYRSYIFKLDYNRSRNELQRIDDKWIRRAINAQRKALRELKLIDPILYQKAVEPVDGPLHIVLHGPSLTPPIDGYQSPDGDYIDTTRTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6S9</accession>
    <name>A0A0D8X6S9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Guanylate cyclase</fullName>
            <ecNumber evidence="4 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_13820</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="KN717478">
        <property type="protein sequence ID" value="KJH40240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6S9"/>
    <dbReference type="STRING" id="29172.A0A0D8X6S9"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000023">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF495">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="264"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH40240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="459" mass="51945" checksum="4718202A97FE9507" modified="2015-05-27" version="1">MSLWKFCSRGSLHDVIIKGSMMIDNFFVFALLRDVVSGLHFIHRSFLKYHGFLTSKCCLVDENWQAKISDYGLQELRRSDKRLPEDLLWTAPEILRKNDMRGSQEGDIYSFAIISAELVTKSWPWDINNRNEDANEILYMTKKGGHPLYRPELTTDGEIEVNASLIHLIRDCWTERPSERPPITMVKSQMNSMDARSGNLMDYVFNILEKYASTLEEEVAERTKELVEEKKKSDLLLYRMLPRQVAEKLKLGKSVEPETFDSVTVFFSDVVSFTSIAAKGTPLQVVNLLNDLYTIFDSIIDEHDVYKVETIGDGYLCASGLPNRNGQEHIKEICSMSLNFITSLQKFRVPHLPNERINLRIGVHTGSVVTGVVGLTMPRYCLFGDTVNTASRMESNGKPGMIHLSADACQLLLTVGGFDVKCRGEVMIKGKGVMETFWLLGRSNELHITAADGEPENPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Q1</accession>
    <name>A0A0D8X7Q1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RasGEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_13455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717100">
        <property type="protein sequence ID" value="KJH40585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7Q1"/>
    <dbReference type="STRING" id="29172.A0A0D8X7Q1"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="202"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="347"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="513" mass="58775" checksum="7A0BFDF9F1520BE7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7X8</accession>
    <name>A0A0D8X7X8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nep1 ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_14380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN721132">
        <property type="protein sequence ID" value="KJH39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7X8"/>
    <dbReference type="STRING" id="29172.A0A0D8X7X8"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13609" checksum="CFE861B248B483F5" modified="2015-05-27" version="1">MKTKSVLQKNVHISVQLLHKLVVRAVDSSQKLLTVIKNPVSNYLPVGSRKFLMTFNTDELILPNKLISTEEDARIVVVIGCIAKGKIVTDYTDRDVKISNYPLSAALTCAKITSGLEEIWGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7Y6</accession>
    <name>A0A0D8X7Y6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719440">
        <property type="protein sequence ID" value="KJH39892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7Y6"/>
    <dbReference type="STRING" id="29172.A0A0D8X7Y6"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="59"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="199" mass="22336" checksum="40F422FE9FA47E73" modified="2015-05-27" version="1">MSDLLTSGMISYPCCGKPLGVAGCSYSNSHVTETMKESVLADFYEAPQPMTAYDPRSSSFYAMDCEFVYTTWGKEPARITVVDQYGADVIDCVFHPDHDLVDPNTQYSGLSEEEIEESRMTLREARDLLFEVVNSNTILIGHGLENDLKALRIVHDAVVDTSVLFRLVFSFFYWRINDKNPIASSNGFEVEEVSDDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X836</accession>
    <name>A0A0D8X836_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718973">
        <property type="protein sequence ID" value="KJH39952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X836"/>
    <dbReference type="STRING" id="29172.A0A0D8X836"/>
    <dbReference type="OrthoDB" id="5864674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="444" mass="50888" checksum="1638C04F6A5230E9" modified="2015-05-27" version="1" fragment="single">MSNTLSSRLGSLTKAINRLNASLDLYSNQVSTQIVIPPEKRQEMEYVISRKEAIKEAVSIITKHRDSVQAALENYTAAADSCEGRTHSPEELKQNTKTNIDKALEQLDKAEDYLSQLITLQIKLESTSTKDNSYTGQALIFNHNEDKEEIVEVILDTGSDHSFITKRLASYLELEDEDCIELIIQAFETKPKKKKCGVATLKLQDAYGQIHKISVMKVDNITPPLKRYKLDQVDRDFLDHHNVKLSINPDSRCQDSLNLLDDRSKMNITLPSGIKLITSRLGYLVTGGHSRHMDTPNESNQTKTTVIDQKSEHEVQTTKSLDAQEFMGPERQERQLQNDEAWQQFQTTIQKRKDGYYVRLPWKNNASILPDNKGMAVKRLQTMLMRLKKTPEILYKYHKTIEEQLEQGIIERVNETKSHKGGIIHYLPHQPVLTPNEETTKFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8Q6</accession>
    <name>A0A0D8X8Q6_DICVI</name>
    <protein>
        <submittedName>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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            <taxon>Rhabditina</taxon>
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            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716741">
        <property type="protein sequence ID" value="KJH41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBD8"/>
    <dbReference type="STRING" id="29172.A0A0D8XBD8"/>
    <dbReference type="OrthoDB" id="5819960at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="433" mass="46701" checksum="C23A7EC6BDFD9C70" modified="2015-05-27" version="1">MPSQSPTQAHPSPGPMQLNKPSPGSNRVVYSTNTIRPPSNGSGHIKSEPSPLGMQQTSGEQMSMNSGISGSTAMSPASCSLFGSSSQNTQTSDQGPPQPPNINTPFPLVTHYDMPPAFQHLQESFQMRNPALQMYYKRRKALLVLPYPCGPNLSNVAPVEPPTFAFLPHTKHYDVAYDRRYPTMNPVLQSQSGMHRQPIQSPQVMSPAFTQPQPPNKAKAPPAKKTRSDSTDSSFASIAPNSGMMMTPNCMPQRHIQQMPPDMLQHYGVVPTSQMSINPGGMQQYYPGASPGTVPTSSTVSVSNTSSMNMTNGMFPMGGVPHSAASMAMSRLPDMSQQMNDNRSQQVPVSGVFQGLSNGRMSTGDQQSLSSPRNQPTQPPYQPQGNQFDISPQCPKCLCLVSNCTGLLPRAFALLEEDPSAKWVCGACESSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBX2</accession>
    <name>A0A0D8XBX2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarylacetoacetase</fullName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_11923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KN716711">
        <property type="protein sequence ID" value="KJH42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBX2"/>
    <dbReference type="STRING" id="29172.A0A0D8XBX2"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0828">Tyrosine catabolism</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="23877" checksum="92FC0FD3DF30DA9F" modified="2015-05-27" version="1">MKCNQCDRSFRKASELTLHQYTHDIEKHHARNRMFQCPECRIPLRTRALLAKHLEASHGSHIDDSVTASIDPCASTQSVLGGSAPIASNPRSFVCSDCNIGFRKHGILAKHLRSKTHVMKLETLKRLPEDSLSLITKRDNGACLNGVDTTDCEKARKSLYEIVEMIRAENQRASAQVAVASSSIGTVKPAVQISSGSDVSEEQPAASPASTSGAQRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC34</accession>
    <name>A0A0D8XC34_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716701">
        <property type="protein sequence ID" value="KJH42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC34"/>
    <dbReference type="STRING" id="29172.A0A0D8XC34"/>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000842">
        <property type="entry name" value="Nuclear receptor-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="549" mass="60148" checksum="873F29371CD893B2" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCD2</accession>
    <name>A0A0D8XCD2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716827">
        <property type="protein sequence ID" value="KJH41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCD2"/>
    <dbReference type="STRING" id="29172.A0A0D8XCD2"/>
    <dbReference type="OrthoDB" id="5866088at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="23684" checksum="3DD15EC7AE712FBF" modified="2015-05-27" version="1">MLTRLKDIPEVLCKYHKTIEEQLQQGITEGRNKAKPNEGRIIRYLPHQPGNHGTLLCKARIGNANIPSKIQEPALVVPNTPLAEMLVHEAHLPYHCSTSQTIANLRRRFWIPSLRQMARKADRKCLPCRRMNNLPYKYRDMDDLPAARVRRTRPFDHVGLDYFGLLTTKLNETSTKAYGIILTCTRTRLLHLELVRDISTKGLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCN4</accession>
    <name>A0A0D8XCN4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716674">
        <property type="protein sequence ID" value="KJH42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCN4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335720" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12860" checksum="C982F0B3B7B50C6D" modified="2015-05-27" version="1">MFLSISLLSILAANFVFAGHPIIEASEKKCIDCQMLLNGTKSAIEEATELTEKFVEEAVKNECDRLKSVFAEICECLEKKVFEELFKWIISEEQKMDVKRGCEHIRFCPHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCU4</accession>
    <name>A0A0D8XCU4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_12422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KN716791">
        <property type="protein sequence ID" value="KJH41597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCU4"/>
    <dbReference type="STRING" id="29172.A0A0D8XCU4"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH41597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26997" checksum="9BC3DDA8A451FD4A" modified="2015-05-27" version="1">MLAFQDTVNRKTAIRKTKPLFQRKFGVAERNRWGLILFKTVRGLFDRLPWPQLYASVENEVELFQTFAILEVVHALLGLVRSPIGTTLMQITSRLVLVWPILYVCATARSSVGVPMLLIAWSVTEVIRYSFYALGLFDVVLYFLTWVRYSFFIVLYPLGVIGELLTLIGSLPEVAERKHLTLEMPNPFNMAFSFYWVLIVLAILYIPGFPQLYLYMFAQRKKVLSTDMAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD02</accession>
    <name>A0A0D8XD02_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H2A.V</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">H2A.F/Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_11509</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716658">
        <property type="protein sequence ID" value="KJH42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XD02"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="19">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="524" mass="58324" checksum="E8007B48CD998F60" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDY2</accession>
    <name>A0A0D8XDY2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative guanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716747">
        <property type="protein sequence ID" value="KJH41859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000011">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="156" mass="17314" checksum="FC5EC0F50F10FD66" modified="2015-05-27" version="1">MMVEYMEKAIEEACKGVKAGDGGPFGAVIVSDGKIISTGHNMVLVSNDPTMHAEVVAIRNACKKRGHFDLSGCTLYTSCYPCPMCMGAALWARLDAIYYAATPEEASMAGFDDKPFHDFLKNPCSDEKRKLEHLAVSDSKRPFELWVQRPDKTIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE28</accession>
    <name>A0A0D8XE28_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716722">
        <property type="protein sequence ID" value="KJH42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE28"/>
    <dbReference type="STRING" id="29172.A0A0D8XE28"/>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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            <begin position="12"/>
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            <begin position="88"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="KJH42079.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="214" mass="24984" checksum="67D56484AF96EE8D" modified="2015-05-27" version="1">MASRLVCLGRFFQNLSLLIIQIHIVIWNNGCFKKKRKKPKFRKTSSASQEDSITCSGEIQKKKALYLSLERFPQHLLDVQLASTQPEEVLETKSSQTLQKGQEEIKGSRSKEKSRRLLPYPEVKPPTFSQKKRREAELEREKREKIASGFYQSRSDEDDTLEKVNSLKEEITEQSRKRSHKTRRSIKDKMKDPKEIDNEDVREMSDDVLGKQVT</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5826262at2759"/>
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            <begin position="51"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11879" checksum="54CD47A188100071" modified="2015-05-27" version="1">MINNLGTRLFKSVTDKAGDLGEKFEEEFSRLSNNITAEVDAIVTEALSLSIYIKTAIVILCILLILIIIRLSAFGFRCLMFRAGYWMHANENKPPPQVFFYFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716663">
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            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="45153" checksum="DF018BFCA17312E8" modified="2015-05-27" version="1">MTENVRYMLTFTLISISYASYCGQAAIPFTFQVLHSGLTVLGCAKPQCFGWNTNGTLANESAQFYRYKRFLAFRIDGKEDGYLRQSDQIPRSPSRNSIAAPSVATCEEHYSTKSCSPGQWVGGIAPKSLVHGSKLQIRCCSYAPLLNSEDRGVAMVTNGQLVVGGEVMNDDNLVSFDYIANIRTELNQSGNIVYAVSIRRMMCTDEDPEAEYQVSQNAVVHNLDGSAQMMPKKKVQEAPIYKQPLQPHYFAAITSTPHFIPQNPAIPNFSQTQAEISSPFHPPMNIPTVQYNPLQMPNTIQAFNGLNPGHQPYIPLSQAAPPAPQLFGGIPRSFDSNMSPLHPLPASVYAQSQSQVPPTPSTTPLPTIPPLTFPTLDQISKINIPSVEDVENVIPPVQKAILTTVARLFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFX5</accession>
    <name>A0A0D8XFX5_DICVI</name>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KN716643">
        <property type="protein sequence ID" value="KJH42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFX5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFX5"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="15170" checksum="FF89DF50D794A15A" modified="2015-05-27" version="1">MMALSLQNLGRGAKLSLVRAKHSLPDLPYDYNALEPVICNEIMQIHHQKHHATYVNNLNICEEKIHDALSKGNIKEAIALQPALKFNGGGHINHSIFWTNLAKDGGEPSNELMTAIKVGVLKDAFFFDVMKSFTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGB3</accession>
    <name>A0A0D8XGB3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716631">
        <property type="protein sequence ID" value="KJH42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGB3"/>
    <dbReference type="STRING" id="29172.A0A0D8XGB3"/>
    <dbReference type="OrthoDB" id="5918007at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="411" mass="43858" checksum="69B5369A557B0905" modified="2015-05-27" version="1" fragment="single">IIFFSEPSVAHSVNHNDSVVGIASTSDADDAEVLPTTPSLSPAIQANWTSQLKSDLGIGITSPPRQQQFTSVQSITSAPAGVEFVTATIPPGLSDYHFGFVDGPQNSEIPVSTSSVANSSSDVLFASGRTTTNATNAAVPQKPNEADRPLNGDFTLKASPPISHSYAQQQAHNSRSLSYADPSSVSYAPPQQDRGISSGNKPAPIPHPPQQSAAHQAPQHMFPTQMPYGSYPYMNMNMYSPVTGVRAEDQYAALYAASMPFGMGVDLSAILPPTTPMSQAGANQQHPGSTQHRSDTHNLVDMNKYASGNARDGGGQQPSNVAPPPGFANPSFMPQPGLSSLFLQQQFPPHPYSFMMPNVGSGRQMYPQEDDRKSYDKMGGGKQAQATPPQHYHNGGYLNSGLNKKPYNWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGU1</accession>
    <name>A0A0D8XGU1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716525">
        <property type="protein sequence ID" value="KJH43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGU1"/>
    <dbReference type="STRING" id="29172.A0A0D8XGU1"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="45551" checksum="F77EF2DC9F6EED41" modified="2015-05-27" version="1">MVNSDSPTTPLDSPLARKNPLTMENFHKFEKASNGTTDSMTAPSATISSTSFNSASLECASKETSTIQNETLKKRRNSAGHKKDYNQTLFENIDYLGCSKLNDPSNEPEMLDLMRVLDEQRMTSAVTVSLAVPHSARGFVVLRDTTGIELTSFPVQRIRFCVRGRLDSAQKHCFSISFTHHGINGEQTHQCHVFRSAQPEMAGRALYCFSQAFSNSGKENMSDNEKRIDYKFEAYLEIRENEGSQSSPHWVLCPQQNNTLKLRRDRQKRLIVQLKQVQLCKVFGPPLTVTKCFGMLLAAGRNLRHSDMQLLELESMGPGANPSVYVINAIWDPRIHVFDVLNTETPRDSRVFLTVAADVIIAEAGEPIRFRLEAKARVFHRDERFYKLPRVALREGYSLTLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHY0</accession>
    <name>A0A0D8XHY0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716565">
        <property type="protein sequence ID" value="KJH43374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHY0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="212" mass="24419" checksum="4A0E2A02AAC8FB33" modified="2015-05-27" version="1">MDNCEATSNKIKRRYVGCYPDDIRCFLDQIFTEITSFCSATHIEYIIDSKLSYYRTRLTVQQFVAKQLRHQSSTESTDAQIRVNTKVGKSFDIFFLAYISVGGGGREIVSNLSAYNLFFLIAKREARERANRKKGTEEKQLVFEYHFARSTVNVLVMLIHLELYWTDWRPSDSLRHHPLQIAGADRKVERLCDGAGINRCEAVKTSQEGKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI50</accession>
    <name>A0A0D8XI50_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zona pellucida-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716561">
        <property type="protein sequence ID" value="KJH43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI50"/>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF51">
        <property type="entry name" value="CUTICLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335651" evidence="8">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="9">
        <location>
            <begin position="35"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="435" mass="50214" checksum="0AB6ACC466852A52" modified="2015-05-27" version="1">MSRMLLNSVPPFLLLFLAGQSIPIDNGVDGEPEVECGSTTITVNFYTRETFKGHVFVKLLKFFLGNSVFFHGFFSNKRCRSDEGERRKVAGITVPFDDCGLSRSRSLNPKGIFVSTTIVITFHPHFITKIDRAYRISCFYMEANEAVTSQLNVVELTTVNITEIVQMPVCKYEILEGGPHGKQLRYGKIGQQIYHQWSCSTENISIFCMLVHSCSVDDGRGDRVNILDSKGCAIDRHVLNNIEYPDNLLAGQETHVYKYADRDSLFYHCQISLQIIENGVVYSLRNVNDLVVRIYRLTQRQLLTVRINKKCDREIAKITSSPLHQKQFLIRKDYLLLTEATFVNFIRSLSRPRIHYPKTVKSVIDFRQQGDRLTTINPRLIRKRRDIHENPSDYMTVDVRAEMKALDIIDTVWKYRKKSKGFFLIHRPLCRSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJG6</accession>
    <name>A0A0D8XJG6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716661">
        <property type="protein sequence ID" value="KJH42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJG6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11833" checksum="12BEA0460E2F10CD" modified="2015-05-27" version="1">MVPKFCQTTVGVPAEVMSFMIGPQSQRKCIRRRFMAKNNTRRNSEEKNTSPHPMEEAFRINVDITSNTLMIDKVDGKSKKKNAHDVHCHHNTDDDGNYSNQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJR6</accession>
    <name>A0A0D8XJR6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GST class-sigma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="KN716648">
        <property type="protein sequence ID" value="KJH42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XJR6"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000031">
        <property type="entry name" value="Glutathione S-Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23829" checksum="012D5507CF76CE46" modified="2015-05-27" version="1">MVQYKLIFLSGRGPAECARQLFALADQQFEDVRLTKEQYHAMKSNLPFGELPVLEVDGRQLIEPMAINRFIARTFGLAGKNLFEAAVADGIADRYIFYRNRINDYHAALLTQKPAGVLRKLNNEVLVPARNKFFGYIITHLEKNSVNGYLVGDSITWIDVLIAEHVYEFNDKTPGFLDGFPQVEAHMRKIRSIPNIKKWIENRPQTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJZ8</accession>
    <name>A0A0D8XJZ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716440">
        <property type="protein sequence ID" value="KJH44903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJZ8"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
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    </dbReference>
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        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
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        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="223" mass="25711" checksum="ED2921E5C7B2E9F7" modified="2015-05-27" version="1">MGISDNDVQKQLRHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQQQRQKIMEFYEKKEKQVELQRKIQSSNSLNEGRLMCLKAREDHIRNVLEEARMNLSKISADQARYPAILKGLIMQALLQLLEKDVLLQCREKDLNLVERLLPECLDSLEKEWGEKTNVKIDRQHYLPTESAGGVVLSAKAGKIMVSSTLESRLDLIAGQCNMSRGIVYEVTREHKI</sequence>
</entry>
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    <accession>A0A0D8XK90</accession>
    <name>A0A0D8XK90_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716435">
        <property type="protein sequence ID" value="KJH44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK90"/>
    <dbReference type="STRING" id="29172.A0A0D8XK90"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13086" checksum="ECDCDE616FB4993B" modified="2015-05-27" version="1">MNARKETDEANPGASVLMLDDMERNLPSVPCYKLTAIAAPLMNHLKALMQVIQDQQLELNTVKQQLYHYKELAECGSRDRSVSEETLTECSTEPHPQERKVMTKRQRAPSVQPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLE8</accession>
    <name>A0A0D8XLE8_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09345</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716459">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335771" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10716" checksum="73AAC9CEF017305D" modified="2015-05-27" version="1">MTFCVFFIKITLIHSCVGPYPATQLERTPLLHRPMSITDSVTAELGRRLERESEEHRFSSDDDEANTGYLICSYSSFPLKILFDLADSLLVMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLV5</accession>
    <name>A0A0D8XLV5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716451">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
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    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8635" checksum="BC559BD3B1578FE3" modified="2015-05-27" version="1" fragment="single">AANPKCCIEDFIRWHSPKDWDDEKQCLSERMKLPDNTWVKCWNEVRAVPVINQARLFNESKVAEEVEDNLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLY4</accession>
    <name>A0A0D8XLY4_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Ets-domain protein</fullName>
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    </protein>
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        <name evidence="6" type="ORF">DICVIV_10592</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="27450" checksum="D7B2B866C3DFC89F" modified="2015-05-27" version="1">MVYPSSVFITGGNRGIGFGLVKEFLKIPSVKLVIAGARNPNNEQALHSITDSRLKIVRIDVESDQSIKDAYLQVEKLVGDSGLNVLINNAAILPPYFTNGAVNRQTLLDCINVNTIGAAVTSQTFLPILRKASSHGTGDHFGVDRAAIINISSFWASIELNEDGSGVLGALAYKISKSALNQLGRTMAVDLTKDKILVVQFCPGWVRTDMGNMGGRIAAISVEESTSSLITSFSKLQKEHNGGYFNRHLEIIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNQ4</accession>
    <name>A0A0D8XNQ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphate transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716362">
        <property type="protein sequence ID" value="KJH46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNQ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XNQ4"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9890" checksum="133A23953012F595" modified="2015-05-27" version="1">MLDVFHVAHVDQESGIYTCVGDQCGFAIEFGAAVTVLLASKLGLPISSTQCKVGSVVAVGLVQASHSVRWHTFRNISLSWIVTLPVAGIFSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNS9</accession>
    <name>A0A0D8XNS9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716410">
        <property type="protein sequence ID" value="KJH45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNS9"/>
    <dbReference type="STRING" id="29172.A0A0D8XNS9"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF15">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="147" mass="16655" checksum="9A97D92C58E0F1FB" modified="2015-05-27" version="1">MTLISIITSILCDPYPETLEALDTLVEIKLSWLSSRMRLWIASLIFYVFVFATCEVLRLIIGRVLPKRLSSELLLEFVGTLQICTPMFDVNTVLNTYGLFGVFVEITVIELANCYFQRDAFANPFPININSSITLVIHGVEGDVTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP40</accession>
    <name>A0A0D8XP40_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716403">
        <property type="protein sequence ID" value="KJH45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP40"/>
    <dbReference type="STRING" id="29172.A0A0D8XP40"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="44611" checksum="2FCB198F6DC267BD" modified="2015-05-27" version="1">MGDAVDLTLFNALSLLLPPFNELYQDLEQQRNNERKIINNVLDPKIYDSSMPFNPPAEVLPLFFVDHVESLNEDQQLMILHGGILLMWLDKRISWNSTQYGNIKEITRRKSQLDGRVWLPKVYLTEIFFRTSDILNFETSELTISSTGQIRCTVNVLVKTSCHFEYDEYPFDRQNCSFTMYSPYTADKMRFIDFGNSERTHYQTKSGNPSKVDVGDFALEKIESRNIYLIPGSKVVGSLEKYPAKMVRSVFWYNLVFRRHNVYYITRMALPLFSISCLSYAFSLFRSPNGLIWLLFCLAVQIMNGAILLKSLPPDYTKMPTVGLIATLVLFETICLLIWRFFTVFVLQISEENAHFRGKLDLAENFLCLYLVIRIIHIYMKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP77</accession>
    <name>A0A0D8XP77_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP77"/>
    <dbReference type="OrthoDB" id="5891911at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13192" checksum="96227CD8508A901D" modified="2015-05-27" version="1">MRSGPFCDRATADIASEALMQHMAQDGFTDTLVSYLKFIFSMPERPDQPTMALQEILEVPFERVDTRVLMSVLRDTRVELTRALEKGRKLKLRYDELHGIISEAEDGIDVENMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPF7</accession>
    <name>A0A0D8XPF7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XPF7"/>
    <dbReference type="OrthoDB" id="10062665at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF59">
        <property type="entry name" value="LDL RECEPTOR REPEAT-CONTAINING PROTEIN EGG-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
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            <end position="354"/>
        </location>
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    <feature type="disulfide bond" evidence="7">
        <location>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
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        </location>
    </feature>
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        <location>
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            <end position="477"/>
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    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="572" mass="63107" checksum="064398522A4F42AC" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ80</accession>
    <name>A0A0D8XQ80_DICVI</name>
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        <recommendedName>
            <fullName evidence="8">Transporter, major facilitator family protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">DICVIV_07994</name>
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    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="KN716377">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XQ80"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="265"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="290"/>
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        <location>
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            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47277" checksum="AB0CDE25AB4A8EAE" modified="2015-05-27" version="1">MSDEDTEAIRVLRASSALIPPDERARNSSLMVKYMHLDADKILSAYGRFGKYQMVTYLITNSVHILFAINMMVMPFITVDPEFDCLITPPPEEYTVIDKCTVMDSNNWTISCSSIPGSNRVKNLATSILGGMLVGPIITQLSDLFGRRLTFLIPLYVAVLSNLICAIAPNYSIFLIFRFFAGVATTGFSVIGFVLCMESVALEFRSLIPFMGCITWVIGIVMNGTYWALSLFSTELSEDKMTGFFLSGLVEFPAGLVSIVLLIYLDRRTVSFFSLLLQAVSMICALYLPLNKKATMIFPLMAKVFNSIVWSSQPLLYTESTPTSVRNVFCGVVGFLGDFGSVLAPYLKRLEAIDKSAPALLIAVMSVMSALIVLVLPETKNKKLPEDISDFDPGPLMRWICGKKECLHTEEVSKENHLPRQNYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQZ5</accession>
    <name>A0A0D8XQZ5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716364">
        <property type="protein sequence ID" value="KJH46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQZ5"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16908" checksum="AD72E3B5AEE959C0" modified="2015-05-27" version="1">MSLIAGVFYGLTFVPVNYMVDNPHKFPKYPEDGLAYVFSHYFGIFLTATVIFIGYAINKHNQPVVSPFIFLPSFFSGLLWGTAQTAFFIANQHLSQAITFPIITMLPGCVASAWSILYFEEIKGLRNMKILGIAMSITLLGAIMVGLSKVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR16</accession>
    <name>A0A0D8XR16_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">N6-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
            <ecNumber evidence="7">3.1.3.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DICVIV_07713</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25674"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EC" id="3.1.3.78" evidence="7"/>
    <dbReference type="EMBL" id="KN716363">
        <property type="protein sequence ID" value="KJH46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR16"/>
    <dbReference type="STRING" id="29172.A0A0D8XR16"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034597">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019178">
        <property type="entry name" value="PtdIns-P2-Ptase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09788">
        <property type="entry name" value="Tmemb_55A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="14 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335891" description="N6-L-threonylcarbamoyladenine synthase" evidence="23">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="24">
        <location>
            <begin position="59"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJH46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="818" mass="89535" checksum="96BB78A6637DD357" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR71</accession>
    <name>A0A0D8XR71_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptor complexe medium subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR71"/>
    <dbReference type="STRING" id="29172.A0A0D8XR71"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="126"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="700" mass="80240" checksum="3008A6DFBD60BEA8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR99</accession>
    <name>A0A0D8XR99_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716360">
        <property type="protein sequence ID" value="KJH46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR99"/>
    <dbReference type="OrthoDB" id="5850077at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="114" mass="13412" checksum="0BF153D4F18ACEB0" modified="2015-05-27" version="1">MQKSVLYQVKIYFLMLQMTKKSLAYFAYIDKRTMQLDAEARHYLRSRGFVKPEYDDLDETCSISYPKHLRVDPSSVHRRNGDEAPTICYNIYCRNHSKCTCKALSKFTPTITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRH3</accession>
    <name>A0A0D8XRH3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716320">
        <property type="protein sequence ID" value="KJH47120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XRH3"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17251" checksum="FED28BC0F3B0E2DF" modified="2015-05-27" version="1">MQHLTRFPDYVVIFLCVTITIGLTNVCSNAVIASIFIPIVAEMARSLDTNPLLYMLPVAVSSSFAFLFPVATPSNAIVFGTGLVSVADMAFSGFFITIGCMVLTIVNVMLWGRYLFTLNEFPLWAYDDVHPMKNVSLIEELLSQNKTVYPDLPFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRU5</accession>
    <name>A0A0D8XRU5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRU5"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336014" evidence="2">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8377" checksum="4F375AC4F11AA839" modified="2015-05-27" version="1">MKFVQTAIVLILIVYVIAINGYIPVISDGENSDQKNSNSDSDGPIKEPYYSSKFAPLTYRIIWALGGFIKPLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="4">Belongs to the cyclin family.</text>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716286">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30034" checksum="953F20D001A62F0E" modified="2015-05-27" version="1">MESPISIAVYHGNMEMVNMLQQWGIIRSHHFPQAFREAAIAGDIEMLIRLWDICGKNTAHLTEAITSCKTMSSPLHVAAAAGHMRCVQFLCQNETLRTLPDAIGDLPLSYAIDNNHLAIVDFLMKTFPNEISNNAIRSTIACKHNKLAKYLLTYAINSEDFIRNVEPVKFSVGVGNFHIAEYVLKQYMCRNKVNTPPWSVDVYEALSEVLVCKLLDPIKKTRFVIAFQLAGVKVSMVNVVKLVNDKFVAATICNSLKHNFNQPRKLL</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716279">
        <property type="protein sequence ID" value="KJH48120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5874823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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            <begin position="42"/>
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    </feature>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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    <sequence length="100" mass="11683" checksum="EAED1DF91F57C348" modified="2015-05-27" version="1">MLELSLAPKDRLMYLLQYSRPTGTNKKIRSFVVNKNAYQNKTPGEISQLKEQKAKKIIEERKVLLKRRLKDIEIREGVRPFTAFGRSPRPSTTCFRTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="3">HannoverDv2000</strain>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="370" mass="42151" checksum="09ABE4B54E89B21D" modified="2015-05-27" version="1">MTCQHSHSSFTSCCFHFQISCYDLQKKIWHLILISKKCIIQQSSNLYGFQSPLPLWDSRFSYFVQNPLLEGNWNQMAMYNNFFHPIPHSLPHLPTSVQNSQINEVQSIGGHLNNEFVQSWGSNETLFDQSQNLPFDNSDTINENRVPNNVDGMNRADEDTNGVNDFEIFPIIQEGNSQVPINIDEYSRISRIISEYNVLKNSKSTQTSVLCDRTGSSNRYEEGQMLSKKVMMGRTKDVGLNTEPEIMDQTNKENDEVTLVYPVAKNVTFNETAITKTLEDNSIDNDYSKRHVTNTSLLSNVCDFKAKVSEKNVDSKRGRDAESHLNSQFSHTDQEAEVVNPSEDVELFCGLEQVNFSTTKINIFGKGHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW03</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
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</entry>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13696"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="213" mass="23200" checksum="2C1AE4770E84DF19" modified="2015-05-27" version="1">MFEYDRLALDVLSLSPKQDQARQWVSSSAQLIPTDDCGSSSGYGSPGRTPLASPQSAEPFGGLSLPSHIQRVFLDGLITVDEPTTQFGVVVAPTDTSRPTKFTENPSVPLALEDGFSKDEIAGFEELLCSPKKAPPTKYQCHICYRTGHYISDCPMRFNTPYDELTPYQGRKKCYGEFQLPVEKAAALGLIKAQHAIPSKIAPIGHGRPPAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="15 16" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
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    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="19346" checksum="38BC29C7974CF661" modified="2015-05-27" version="1">MPIRERFVNRVLERSYHTECLRCFVCNDALTSTCFMKEDTLFCKDHFYITALIDASVQNAHNVEMVSYPIQRYGKHQAYTASSKPARHVREQLAAETGLDMRVVQVWFQNRRAKEKRLKKDAGRRWGQNGNIKTDSDSNSPSGSVTGQSPVYGTLFIIFPDKKKQHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP9</accession>
    <name>A0A0D8XWP9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716275">
        <property type="protein sequence ID" value="KJH48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWP9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="22160" checksum="D66E01D44BEA1F5A" modified="2015-05-27" version="1">MIGTMVLLKKIPTPIVKMIVQGEADESCTLDDNLVAYISGLNIEQFEGLCSYIREHYSRNLDALKRKTGEADESCTLDDNLVAYISGLNIEQFEGLCSYIREHYSRNLDALKRKTGYTELTAFERRCVAEYERRVHVEKAKEMENDFDIVEVYPGHGVALPVKRKQPTLTPVNSQLNEVAILSCDEDVNMDDGMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXG5</accession>
    <name>A0A0D8XXG5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IBR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716267">
        <property type="protein sequence ID" value="KJH48459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXG5"/>
    <dbReference type="OrthoDB" id="5786205at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31063:SF3">
        <property type="entry name" value="ENHANCER OF POLYCOMB-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31063">
        <property type="entry name" value="PROTEIN CBG08668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IBR" evidence="5">
        <location>
            <begin position="529"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="769" mass="88886" checksum="48095A09D68EDB84" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXN0</accession>
    <name>A0A0D8XXN0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylyltransferase and sulfurtransferase MOCS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UBA4 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-like protein activator 4 homolog</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">Sulfurtransferase</fullName>
                <ecNumber evidence="11">2.8.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EC" id="2.8.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXN0"/>
    <dbReference type="STRING" id="29172.A0A0D8XXN0"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY08"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF139">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14864" checksum="824E929B88D8E6F0" modified="2015-05-27" version="1">MLGLIEVFSMERNGETPRGSVEIYIEASMNMRLTSRSVRGKLNLETLKMTTRSPQYFVQSELDDASYLSFDMLQRIVNGILKRGVPIPIHPLFKLQKPTLTFIERSMLLETNFDLNPNLIRQLTSEKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYC3</accession>
    <name>A0A0D8XYC3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYC3"/>
    <dbReference type="OrthoDB" id="7754674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22250" checksum="DC04994A84A71A21" modified="2015-05-27" version="1">MFITGVLLEIIETSTFDIYASFHGNLDSSWNRELRNICGEYFQPESGAFRSLGGTRVRNREYPWTLGLIALSQTQLNYSPHEPMQSRQLHVYPELRVKDLRSIPKFTSSFRVVNMTIHSNFDPCNNTGDIALLEISPNMLTEAVPICMPRVDERIPDNLTATGFGLNCEITNYKPIQFIFLIASSFETRTKSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYQ4</accession>
    <name>A0A0D8XYQ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_04964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716252">
        <property type="protein sequence ID" value="KJH48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYQ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XYQ4"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="33605" checksum="C81731F3037BF3CC" modified="2015-05-27" version="1">MGAYKYMQEIWRKKQSDTMRYILRIRTWQYRQLSAVHRVSRPTRPEKARRMGYRAKQGYVIYRVRVRRGNRKRPVTKGQTYGKPKTHGVNELKFARSKQAIAEDRVGRRLGSLRVLNSYWVGEDSTYKFYEVILIDPFHKAIRRNPDTQWITKPVHKHRELRGLTSAGGGFVILIRQPSVMAVFYSGFKQHIFATTFSSVSNIVVKPSHLEVVCESDMHNVPKGSEKHFRVQVVSEKFEGCSIIQRHRMVNSCLSDELSGPVHALRIDAIAPSNWVGQKTHPSPACRGGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYW7</accession>
    <name>A0A0D8XYW7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XYW7"/>
    <dbReference type="OrthoDB" id="9991628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002542">
        <property type="entry name" value="T20D4.11-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431:SF5">
        <property type="entry name" value="PROTEIN CBG06905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37431">
        <property type="entry name" value="PROTEIN CBG06927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01579">
        <property type="entry name" value="DUF19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
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    <sequence length="355" mass="40281" checksum="030CB8DC07C2F697" modified="2015-05-27" version="1">MTFEFRFLSFPIRIPEDENVSDVQVLVDPIMTELWFVLVYVLPVIMSQCPSHVTSRIQECVRPVAEYAKILNNDQITFGNDLSTSSSSTSEFGNAFSLPKIGRRVFNELCKLIAKFNVCVNEYRMQCLRHITISLIDSSYGYLCNEGYNKPNMIFTAFMESAECLMELDRKPTVKRCHDETLVEIETANIDSNISMAAKLDRMCGALNFFASCVKTPIKQECGLSAWQVIYRVLKDTTNTLMPGCQFLASSTKRIPYIETTAKAQILTTAHLPLTTSTSLMTNFKGHKDTMKIPINRQNDMNRNVLSQQLSQLNANHRLNLLLTLISITILFNFNNGCVCYVYEISNSKFSLVIL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48984.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="608" mass="68720" checksum="BF529812DA9EE7A6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZC2</accession>
    <name>A0A0D8XZC2_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716242">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF34">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
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</entry>
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            <authorList>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="13">HannoverDv2000</strain>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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</entry>
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    <accession>A0A0D8Y1L4</accession>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </location>
    </feature>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="32369" checksum="D9AF8692AFFF71F5" modified="2015-05-27" version="1">MQITGEGHLPLHCASPLLGTYVKTRIVNTISRFRRDLGSKGSFGGKENRTERLKNQPIVFVHGVSDTAGEKMRQATNWFKSMGYKSSELYSTTYFNGAQGNPLKWVEYGMRCEYVKQIRALIVATRLYTGRAVDVIAFSLGVPVSRKAILGGRCVDSGEYLGSPLTKFIDTFVGVAGPNHGISLQVAGVTIPGCVLSVIPVCNQITGLYSGFCPNESEFLQDINKQQGYEGQHIFSIHSKKDQIVGHMVCDKVTSMIAGQMGEKLFEHLNHDDTFRKSYETQLQMIKYHTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3A6</accession>
    <name>A0A0D8Y3A6_DICVI</name>
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        <submittedName>
            <fullName evidence="8">CD36 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CD36_fam"/>
    </dbReference>
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        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="491"/>
            <end position="517"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="542" mass="61413" checksum="CF774845A4312E7D" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KJH49071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9994" checksum="E12498F9D69C3242" modified="2015-05-27" version="1">MKTSKSLQEDGNYTSIQSIMSTKRKNTLIVYEIHAVLFIPLNHWLDHSYATCQNAKFEVNGRQSKPCCCTKRDTITTWAIIVLLFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3F2</accession>
    <name>A0A0D8Y3F2_DICVI</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="EMBL" id="KJH51220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="9141" checksum="9AF506E22DF88AEB" modified="2015-05-27" version="1">MRAYIENVRFLEQHLADLIEDWKDDQDPRIPDRNRYVPEEEREEVERITKEGKLARRQRDAAKRAEEEALGMWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3G2</accession>
    <name>A0A0D8Y3G2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="SUZ"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="405" mass="43454" checksum="17540013FCEF65D0" modified="2015-05-27" version="1">MSEVEGITEIAFMMISSLRMKSAVQVGATDSPPGDVVEDWENDEASESMEKQLTERFKQIRILQRAQADKEARKEKAVRCQEEARLNPCFLSTPLVTPAGPGGAPPAPVRILRRPESSDKIREENFRAQRAKAEEAARNQLTPEQKEALYVKARDRIMGPEYKPDNSQNAQNVAIVSRCKSPEQIRVPRFTDLPLAGTMSGPSHDASLGGPMIMSSINTVSGVTSPTAVGAPIVATQQSTQQKPTSLLTMSSSPVGMSVQQATAIAQGLSQQVIGQQQACMVSSPPPPQSITAYPQYVIAQPQQHMPYTMAVGSNQSMVPFIDTTRPPPAVTIPSITGHVNPPQVATGVPLSLPQVGRGAPVMSIYPPGSLTAALRGDSGGVPTVSVCNSQQTKKGRRSRNKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3K1</accession>
    <name>A0A0D8Y3K1_DICVI</name>
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            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3K1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3K1"/>
    <dbReference type="OrthoDB" id="5973346at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336168" description="MICOS complex subunit" evidence="9">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="519" mass="55677" checksum="FA9EE3919FEB1BA0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3M6</accession>
    <name>A0A0D8Y3M6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein SPEC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716201">
        <property type="protein sequence ID" value="KJH50629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3M6"/>
    <dbReference type="OrthoDB" id="361532at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071683">
        <property type="term" value="C:sensory dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019230">
        <property type="term" value="P:proprioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050954">
        <property type="term" value="P:sensory perception of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042330">
        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF7">
        <property type="entry name" value="PROTEIN SPEC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26231" checksum="2B3F8CBDBE234923" modified="2015-05-27" version="1">MLLKMQNLADKARGWKLVQKTLPRIIEYGRSEGILQTNTQNNAFNITGVVLAAQEEAHTQKETKTGDKVNLPTNDITMMHEAIPFLPVPVALLCLFLNIAIPGTGTILSGISALCMGQPRVNLKEGRKLVTLVVNLLVGISQFFTITFLFVGWFWSIAWGGLLIIHSRKDMSLSYVTHIRFIVQYREALQQRRQEAVATAAIEALTKDSILHRRDVKTLVKTHKQQAKDKKAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3N7</accession>
    <name>A0A0D8Y3N7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KN716197">
        <property type="protein sequence ID" value="KJH50782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3N7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3N7"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02667">
        <property type="entry name" value="Peptidase_C19K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF39">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="25"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="526" mass="59282" checksum="914C49B6DDB260C9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3W5</accession>
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y3W5"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336194" evidence="1">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="35065" checksum="61CF881B5F322867" modified="2015-05-27" version="1">MLFKVLLISTLYAFTLSYPLQQGCICTCHQSCCGDCCSSQQNEPVTTTTTTEAPQTAECCCDNCCNPQQDAPTTTTTQASIAQCCDKCCSSQQDEPVTTTTQAAVQCSCCCCETPQEAPIITTTESPSCCCGGTAGGSVKSQAQYPAQNGGTRRKLANSPLQYAAPNANTSAKSIRGKCPIGFKRFGSSCYFVELERLTFSQAERNCIEMGATLFAPETEQEWREVMTLAPLYAWTWSGITQNGMDQTPQWKGTSNTMNAATVNWLIKPFSSISNGWSMISKCAAYYNLGLEQSNYVYYYSCMLPFFSICEKPINALSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4E1</accession>
    <name>A0A0D8Y4E1_DICVI</name>
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        <submittedName>
            <fullName evidence="11">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716235">
        <property type="protein sequence ID" value="KJH49436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4E1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4E1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF110">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="269"/>
            <end position="291"/>
        </location>
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            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
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            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
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            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJH49436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="419" mass="48694" checksum="76B072D374161FBF" modified="2015-05-27" version="1">MDQQLREIEDLLVTNANPESNDKITRLKKYVKLVLPHVALVAVVCLYAVIGAYVFYRLESPNEDRLKTIGKALIADMRNHLIAKIKEERGNEKMWRNTIEKELYGFNDKIYKAFKEQYVRYADVHIAPTNEFLRKEELERPKRRRNKLRSEKGEKMWTASSALFFAATTMATIGYGNIVPATSSGRIACVVFALFGAPLAIITIGDLGKFLSECTIWLYKEMKRLRVSFYSRWKRLRECNKDESDQSNIKTESPRSLDWEDLIMDKTEVPVLMVFTILLLYIAFGGVLFSFLEGWTYMDAFYYSFISLTTIGFGDIVPENHDYIVLMLAYLGIGLAVTTMCIDLVGIQYIQKIHYFGRKFRGTDLLQLLRRKRMIERRLAMGQGDEILQMYIQQLQHQIPEPAVIDQQWEEEKAFFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y528</accession>
    <name>A0A0D8Y528_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_01864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y528"/>
    <dbReference type="STRING" id="29172.A0A0D8Y528"/>
    <dbReference type="OrthoDB" id="5850415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7984" checksum="618F0E54403BA98C" modified="2015-05-27" version="1">MCEAMTKIAVEFAFFPVANIIGGQSLLMFLIPTVIFLIMIWAFCPETSRRSVGEVLNEIAMRKNLKVSFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5E2</accession>
    <name>A0A0D8Y5E2_DICVI</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="131" mass="15251" checksum="4953A6865ED5D4C7" modified="2015-05-27" version="1">MYNGLRGPFPCSNGMINSLSNAQQQLKSRSKMHEMAVRQRLITDQDPRSQGLVQLSAEERKTLLQEGYPVPTRLPLSKAEEESLKIVRRKIKNKLSAQESRRKRKEYMDTLESRCQAYFNENNQLKCNKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5K6</accession>
    <name>A0A0D8Y5K6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y5K6"/>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
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        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="178"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="242" mass="27932" checksum="1CB3454DCC0A0543" modified="2015-05-27" version="1">MRRYCSKVVGAEPLTSDDHEIVVRYKQHGGPMTGSLYGFMAHFTTVCTDVVLTDFTGSIQSPGYPNNVWTNQYCSWTILVPPGNFIQLNFHNFIIERRFSYGAIPGKCSENWLKFGDGEVTKATVKIGKTISEMSNLTETCSDAVKPMVVKSKKNILHITYNSKKQEQNHFWLTWTTIGCGGNLITPLNVTANLNRMDRDAEKLECAWQVKVFFFFEEYEIRIEKKERRLIRRIYVEEMKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y696</accession>
    <name>A0A0D8Y696_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CHCH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_02128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716178">
        <property type="protein sequence ID" value="KJH51697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y696"/>
    <dbReference type="STRING" id="29172.A0A0D8Y696"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="28577" checksum="BF6BF79A3E62DF04" modified="2015-05-27" version="1">MYEIPEMPVSVNTYTLNRYGVWILQRVRKLASAVRRSFYRFVTLEIAILAASFIGFYSLRRSEKSRRFLYQHYPLLSKAYYWAEDSISFGQLTDVQNNVVSFVKSITATDKSMKLRRVVSPCRSMQQNRSLEDALSLIQIVNKVEFKQFEMAQAGPFNRIQPVTPPLKGSFPLDHDGTCKVEMLRYMCCLYENKFLNSDCRDRAKSYFQCRMHNGLMDPEEWVKLGYGDRNGLWSSCMTWYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6H5</accession>
    <name>A0A0D8Y6H5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716213">
        <property type="protein sequence ID" value="KJH50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6H5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6H5"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="237" mass="26277" checksum="5744489051ADF9A6" modified="2015-05-27" version="1">MYQLSFQYWLNDYASNIGFGVFHSGIEVYGIEYSYGGHPYALSGVFENSPQDAEELGENFKFRQSILIGETSFTAVAVRELIKSLGQEYRGDRYHLISRNCNHFSAVLAKALTGKDIPTWINRLANLSGSIPFLERCLPQEWLTPVALQQSLTDSHGTHVRSHGKQRRNSLSIDQAEDVLNIKLDESQAAVVTDSDFGRGNKPSAPSSGIHSGSESPPSIQRIWAQIKSTMAGDVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6N4</accession>
    <name>A0A0D8Y6N4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_01238</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6N4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6N4"/>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="304"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH52528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="504" mass="57562" checksum="B25A164EABBADB7D" modified="2015-05-27" version="1" fragment="single">IVEDEYRAHFADSAERNVYHKTPVGLHRDFTRRDQNEQSGQYRYSGVFIDILVASVLLIVSSIAVFMSPFAISLSFIIYFCFALTIVIAAIGLIGFPLLSRKSILPCVNLWKPRHIIGAVLIALPFGVAICVMPLCILNECPNIPLMPLRLLFSYIMIVALFAHCNFSQLGAWPKTIQCIIVGFIHIVSVYYCQINIHRIDPQTLCDNKTDVIFLNMSVTSSFFIWEMILDVVLSIILVGFLNYQFEAAFRMSFYGDVQARRDTQRMQIVRDQADWLLNNVIPAHAVESLKTDTKYSENHESTAVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELLDRPEFCHIEKIKTIGAAYMAASGLNPERKRNMQHPKEHLYQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSAHTRDILLDRYEFEYRDHIEVKGIDGGMDTYLLVGRKIDRIPPSVTEHKVDQRAMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6V3</accession>
    <name>A0A0D8Y6V3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6V3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6V3"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26634" checksum="02E408564A1E84C7" modified="2015-05-27" version="1">MQLVHQQRIPGGVIATGVILIMVAFLGFYGTKNHNQAALFFLIVSGWLRSDEAIKWDAQKAFGCCGLEIVNEQNTTCKKLPCHDECKPCLPVIVDVTSRNLSRVGLLGLLFSFSEIAGVWLAYRFRNIRDPEPRMLPDLSPHLHTRECNVLIELLKKCYQEKTIGRYFGKCSYWDEAVWQCTKKERILRRNSNPRYKKPSVELRSLPESHWTPALKKLKEEGRLSANDTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Z5</accession>
    <name>A0A0D8Y6Z5_DICVI</name>
    <protein>
        <submittedName>
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="271"/>
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        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="31611" checksum="9CAF462B2016BF92" modified="2015-05-27" version="1">MEVAHYVKFDNRLSLKICLIKFVDISEESEGTSSMPPGLEVTNTSTSSPCTEDGVKPPKEENQENENETTKEKEQVLDMSDCHMPRRTAARSISECESAEDREGQRRILRNSHLAKVRPIMGKRQSFDLPKDERHSVEATSEQDVIEKYYQRNQATINSLQSRTLRRNAEHRHPVSLVSERSGRSEIVMPSPEFTQRNNFSKSFYWVAANHKKIGFRHIFMLLLVLIYTLLGALMFYLIESNYEKDNPVFKIPIFFEYIVVVIKEVATFTLTR</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="139"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH51997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="30238" checksum="082AA0D45C3958FD" modified="2015-05-27" version="1">MTSLVSILLMTLIVHCCGDVIRTVYCKDQCADYLKIPENSMPLCRPQHLKLKECGSVISCDWSEADRDKVRPIANSTDISCCYRTFIKAKGDCVEHPVSPTESTEGSRLPDDRRDVQFLSWLLCIAFLAIVVLQAGYIIKLKFSGSTDQKVSHCDEATFPNAIDYRASTVLLAVFMSETMSFFLGCGGGIEVILFFHMFDVLKSQEYEEFIGLGCGFGGLGMIGGYGGMGGYGLGIGNGIYGGYGGYGGYGGYGGYYGGYGEYYGGYGGMGIAGGCGGVCGK</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
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        <text evidence="1">Belongs to the GrpE family.</text>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="331" mass="38039" checksum="FB7BDE402EF971A0" modified="2015-05-27" version="1">MYFANSNPGGEMEELRKQPLNEITDNNFDRLGWYRMDENGKFHVNNGIVKMEEIHKAKLPGNFNLSRPLEMVYPWIQSARMYDGSQRQVIVTHAEGSNLHITLQVNDEVDGNRLVFFHNASKISDFTGTIIVDSRSNRYFNVTMYGASGKINGAVKFNTERDSNEIFSFTTYVHDLNASNRSMIIPMPAVVESGSRMICMYADEQREEQALCRIVQYYETPLEIDIEQNTWHEMVGSCPSCNQINFNGLSRFLNPMSWVNGVSSLGEFVMMATDVLVYVCVLVVIYIVLTKIVIPICKCWICPMYIMSHSKSKSKKREKTERRNVEDDVRV</sequence>
</entry>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10747" checksum="69FCBEE3EBD876AD" modified="2015-05-27" version="1">MKSHISELRSNFRSSLKTSQHLPNDFVITKTNTSATLLPYSYVPTCTNRRSPFRVHSFWYDFLPCFFPGQLTFLTIWTVQCDNYSCLILCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y900</accession>
    <name>A0A0D8Y900_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptobrevin</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y900"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Synaptobrevin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="97"/>
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            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11365" checksum="079D6CE1A98B37D5" modified="2015-05-27" version="1">MENFNYRVSKIGCEDKIMQTRRQLDEVMDMMRSNIEKLSERSERLEDLACRAEVLDMSSNEFQRCASEVRRQKQWKAYISRAATIGLIGVAVISTIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9R9</accession>
    <name>A0A0D8Y9R9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_02514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KN716186">
        <property type="protein sequence ID" value="KJH51311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="61092at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="762"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <begin position="30"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12879" checksum="57D89A0318A9C932" modified="2015-05-27" version="1">MFFLIWSCKMRGSLTVLLLIFTIIQLTLSQNLKNEGKSQKPVLIYCHLDTVMLKPKRDAAIPEWGDLGWAWKKRNALNDLYPKRLLRSSQLVKNNPEWHDLGWTWGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH53631.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH39885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="18713" checksum="FD3C3B444943F719" modified="2015-05-27" version="1">MPASLVLQVDRLVVTTTHMNRNRRFFIYGIVENNARNQFFQTTEGSISVEQYFQEKYKLALRYPLLPLVTERQGSTGINFYPLEVLYIEPGQRVENKKLAGRLTEKVIQQTRMLPQEMRNHNIRQLVQANLMNGENQYLNSFGVGIISCFFLIPFPYFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8X5Y7_DICVI</name>
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    </protein>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
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        <property type="entry name" value="4Fe-4S ferredoxins"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="250" mass="28195" checksum="A533C41759502CA4" modified="2015-05-27" version="1">MIWLSVTFFSRRRSLQDVVINFHKAIEDITMNRKGPLQKTEESDKPSRIAIVEKDRCKPKNCGLLCKRSCPVVKMGKQCIVVEASSTIAEISEVLCIGCGICVKKCPYDAIKIINLPSNLANETTHRYSMNSFKLHRLPTPRTGEVLGLEGTNGIGKSTALKILAGKLKPDLGKYDTPPDWPSILQYFRGSELQNYFKKFLEDNLKAVVKLQYVDQIPKAAKGTVEFILSRKADRGNREQVQQDMGRFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X641</accession>
    <name>A0A0D8X641_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN718572">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:dynein complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="95" mass="11056" checksum="7568035B0C4DF451" modified="2015-05-27" version="1">MLAEFRSQHKAAHRSELENERTLLEESSAKEKLLTERIVVLETNLRNAEQELARCRSELERLKVEHNSAADVGAALEEERRKLKILPSHLRDDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7B9</accession>
    <name>A0A0D8X7B9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722094">
        <property type="protein sequence ID" value="KJH39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7B9"/>
    <dbReference type="OrthoDB" id="5847499at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8542" checksum="D894BD9E8F3834B0" modified="2015-05-27" version="1">MFMVLSELNRAPFDFAEGESELTEEAAVNVNLSQIWSDTLHINHQTKEARWSLYDSCRYRKHIHNHRAKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8F2</accession>
    <name>A0A0D8X8F2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maelstrom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the maelstrom family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716995">
        <property type="protein sequence ID" value="KJH40845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8F2"/>
    <dbReference type="STRING" id="29172.A0A0D8X8F2"/>
    <dbReference type="OrthoDB" id="24555at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060964">
        <property type="term" value="P:regulation of miRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024970">
        <property type="entry name" value="Maelstrom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13017">
        <property type="entry name" value="Maelstrom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Maelstrom" evidence="3">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="257" mass="29966" checksum="09DA78F9FBC5C57F" modified="2015-05-27" version="1">MYNFSSRRRRRSEHRTEDFRRLPFVADDDVEEDEFFPIGQPINTTSDGIDCFDQLFAEKFEGDRILVRQAIMNQTDGCVEKIKELRFLLAAVQTFGNVDGICLMAEYAMNEFNLKDGVVDRFSTLVGPWQVANDIQRHRAEFHSNETHRIPLSIGLTQMDKRQLVMEILGRCEPEIARSQGICVGLYTEEMEDIDDRFNRLYVGDKNPYILTDEDSRRWIICLKQEFRNMIAANQHLARSLGLDYIGKIQRNTNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X970</accession>
    <name>A0A0D8X970_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716894">
        <property type="protein sequence ID" value="KJH41140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X970"/>
    <dbReference type="STRING" id="29172.A0A0D8X970"/>
    <dbReference type="OrthoDB" id="5806791at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="135"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="461" mass="51155" checksum="97431780C40A19EE" modified="2015-05-27" version="1">MVSGPFVEFYSKQSKVGCQNSLVICYSYMNVEDHCLKVHVTVATESREDGQRLSRSGNVTPFVIDVRNEHDVLDQLIRDHDQVVSLLPYVFHPLVAKLCIKNRKSMLTSSYVSPELEALDEAAKNAGITIMNECGLDPGIDHMLAMECIDEVREHGGKVVSFVSFCGGLPAPEYSDNPLRYKFSWSPKGVLNALLNPARYLLEGKVVEVPKGKVVDHLYPIDFMPGFNLIGYANRDSVKYADIYGIGSECRTLIRGTLRYKGFVETVKALDAIGLLSTQQQEIFNPVVGPDLTWKQLMAFLLNQKLDIFPDSLRNLAADRIGAGNQIGVRALSDLGLFSDIVADRHGCALDTLAAYLSKILAFSERERDIVILNHDIGVRLQNGNAERHRISLVAYGEVKGFSAMSRTVGYTCAIVSNMMLQGEIQRSGILRPVSKEIYRPCLKRLSDYDIVAVKSINLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAY4</accession>
    <name>A0A0D8XAY4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-loop-helix DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716765">
        <property type="protein sequence ID" value="KJH41760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAY4"/>
    <dbReference type="STRING" id="29172.A0A0D8XAY4"/>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF110">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16238" checksum="770E0887571A5070" modified="2015-05-27" version="1">MSSQLRGSRPNQERRNARERNRVHQVNHGFDLLRNRVPKVGINKKLSKADTLREAMGQSHLILGYSAPSCSANSSLYNHSEMEFDIYFPTTSTSSGSSQQLSPIQSVVYGTTMPPVQQQCNRGKLLIFKFHIYLYRSLSDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB89</accession>
    <name>A0A0D8XB89_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716743">
        <property type="protein sequence ID" value="KJH41880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB89"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="9226" checksum="CDA96EA3AD94DE12" modified="2015-05-27" version="1">MSEKFSQHKSANGSSQCLSIFLWINTLGTRRTLRKEQLLRENTGVKTINKSVNNNNNCIGQKCLRDEFIAIQLDSRLHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBH1</accession>
    <name>A0A0D8XBH1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CUB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_14298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN720291">
        <property type="protein sequence ID" value="KJH39811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBH1"/>
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    </dbReference>
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        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH39811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="121" mass="13661" checksum="0F7E48FB459D9A68" modified="2015-05-27" version="1">MRRYCSKVVGAEPLTSDDHEIVVRYKQHGGPMTGSLYGFMAHFTTVCTDVVLTDFTGSIQSPGYPNNVWTNQYCSWTILVPPGNFIQLNFHNFIIERRFSYGAIPGKCSENWLKFGDGEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBP1</accession>
    <name>A0A0D8XBP1_DICVI</name>
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            <fullName evidence="5">Hydrolase, NUDIX family</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">DICVIV_11983</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716720">
        <property type="protein sequence ID" value="KJH42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBP1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
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        <property type="entry name" value="Nudix_hydrolase6-like"/>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="97"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="29072" checksum="CDBA5AAE7F089390" modified="2015-05-27" version="1">MSFKERYDIFGGVTVSASDLGPDQKRLEVFSTIISESLNKWRKANVQGVWFQIEINDSHIIPLMVEHGFQFHHAQPNYLVMTKWLPATPSTLPRYAHTLIGVGGLVVDSEDRVLLMKEKRGHYLGWKLPGGASDPGENIFETASREVLEETGVRATGRAIICFRQAGVSQFKSVGDIFFICLMDVIDGEIKSCPKETADCKWFTRSEIDVLPKSEFLEIQKEILRRYDKWKSAGRLGCHISISQFSGKNYNMFFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC96</accession>
    <name>A0A0D8XC96_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
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        <name evidence="3" type="ORF">DICVIV_11815</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716696">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF72">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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</entry>
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    <accession>A0A0D8XDH4</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDH4"/>
    <dbReference type="OrthoDB" id="5779597at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJH41822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7367" checksum="99F73B3EB1BA23D0" modified="2015-05-27" version="1">MSMQTMNNETREDIRSQFPIAVNLTEGFGFTILTTMAMIAEKIVETFNAASATIMSPQECPIAPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDY5</accession>
    <name>A0A0D8XDY5_DICVI</name>
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        <name evidence="5" type="ORF">DICVIV_12047</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF362">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
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        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="280" mass="28151" checksum="0713E33D2E5553DE" modified="2015-05-27" version="1">MNGKAAAYASISLSAIATVIMLLSVSRLSSKLADISDDIEREMHEFKEIEKENEMHVRAGRDTWNSYNHRERRASGNCHCNDDNRCPPGPPGTPGSAGEDGTPGLPALRGAAGMRGNMAAVAMDSRGQCRLCPNGEPGFPGPPGKPGMPGVPGPDGVGSDRAPTGSPGLPGQPGSAGESGRPGQNGPPGDRGENGTKGNKGPLGPPGQPGQHGENGRPGEVGSPGKNSMNGAPGPAGRNGEMGPPGSPGMPGSPGIHGGPGKDAGYCVCPAQRTQKRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEL1</accession>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="318"/>
        </location>
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            <begin position="353"/>
            <end position="701"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="82101" checksum="2E551785C055EDB4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF19</accession>
    <name>A0A0D8XF19_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NTR domain-containing protein</fullName>
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    <gene>
        <name evidence="7" type="ORF">DICVIV_10761</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
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            </authorList>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="22667" checksum="7CAEC0E71C05E146" modified="2015-05-27" version="1">MCGFLLRWGSGCDGHCDCSNGASCDRLTGFCDCRAGYMGKKCEIACPDGLWGANCIHHCLCMHNGGCNPETGECTCAAGWMGPACEFLCPFGQYGLNCARDRVHPDTLVQIAMTCVNVKMERSVIQSAATAPVSPDGEDGNAIDVCLWIIFCYLHCILNVLLYVQYVLRFSTDQPQAFGAGQLHLYARLVQCHCGSSLMKLLSTKIGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFY4</accession>
    <name>A0A0D8XFY4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716641">
        <property type="protein sequence ID" value="KJH42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFY4"/>
    <dbReference type="STRING" id="29172.A0A0D8XFY4"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="459" mass="52196" checksum="E3BA74611CF5465B" modified="2015-05-27" version="1">MNGHLVEQRAIKTVMLGVFGIKQKEHPEFSSSVYLSRVIAPDLSRRKGTQWGTYKSINHKFMASLASISVLPLRLDLIIFKLRFQEMVNDLKLGISSVMEACYEIRHSKGFKIFLELVLLFGNYMGQSSKTYKDTFAFEMSVLTRLTDTKDVDNQHTLLHYMVDSMRKLDSKKARFVHEDFYHCVAAARVNADEIEKGVSALRQNLENYLRSYKKQSDDDRFADVMLPFLSNAQSEVATIETMHNKMKSDWASFTKFFAFDEKKYPLEQFFTDMKTFKEQYETVYRELETEKLKADKEREMKSKSKRETVLPSAKVQSTCFGIAASRLQTAVDSPGVLDELDKMMAGGGLAKMLQGSRTPRNAAAGRTRTGRAALQRQRSRGADVLLRESVCTNEHKMSSAARIPLSVLPPAPEKVRIRRKGGPTVEVTLRPPEISPTHKENDGTAPTTDELLARLKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG71</accession>
    <name>A0A0D8XG71_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716637">
        <property type="protein sequence ID" value="KJH42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG71"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="38" mass="4391" checksum="63099546DBF9DB66" modified="2015-05-27" version="1">MTLYVLAQRLELHLESQDSQVSFLSVRISFHDRGSGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGI1</accession>
    <name>A0A0D8XGI1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_10222</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KN716528">
        <property type="protein sequence ID" value="KJH43765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGI1"/>
    <dbReference type="STRING" id="29172.A0A0D8XGI1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000333">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH15"/>
    <dbReference type="STRING" id="29172.A0A0D8XH15"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:reticulophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATG2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="460" mass="50906" checksum="9AD6B4CAB22290B8" modified="2015-05-27" version="1">MQNFGTALIIGYSFVNYFILACEWMNGGSIFHLATVKKYRMLASAIQETPLSSSDVSTVNPCEKVTFPPTSSINDMKKINTSTEATHSDRNRAYSLSTDDEFCMVDEDIIGSGVTNPTGEPNIKYIGSQSGRCPVNPGITLDPHHFRFPTDWHGDVLAALPADFPTPIARYLLRDISISLHIYGGSDLSDDPPKQRSYSTAEYREGKGKNQFISPDAVGGKHRDHSVCVVLELSKITFVYQLFNKNCPLMSMKLFTIHNIRLLDKLVASQIKEMMYQYSSAEQPRRTCAPMLAVRMVETHKNEGKLRVWLLANYVIYANLVPDIITNQPLLESSTIIKPKINVPSTEIHEVYRSPIKGESFGTKSCVLPCVSSSGNPPVELSSSNTNREDSSVEGLVSALDDLCLAGDWNSSGIGSAMCICLIALECSNITCIMKLIFDVKNSYADFALLFLPRFSNSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHP1</accession>
    <name>A0A0D8XHP1_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716496">
        <property type="protein sequence ID" value="KJH44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHP1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="11930" checksum="D984BCEC3FAC3792" modified="2015-05-27" version="1">MCPARNLKNIDPMYLTIPGTITTNMNFYAGGFHLVEHPINNVSETRKSDRLASIMRSRQKLFQTELQSINGSTSLGFDTNCQMYSKATRPITEERGDFLTLNPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHX2</accession>
    <name>A0A0D8XHX2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="530" mass="59879" checksum="B762F5269F25933E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI72</accession>
    <name>A0A0D8XI72_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EB module</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_09690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716485">
        <property type="protein sequence ID" value="KJH44293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI72"/>
    <dbReference type="STRING" id="29172.A0A0D8XI72"/>
    <dbReference type="OrthoDB" id="5865965at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="248" mass="26266" checksum="A58049BCD2CF5EEE" modified="2015-05-27" version="1">MRGILENSQNTLPVPNVLNVQSTLGEQCVLESDCIVNHSHCFEGVCKCDANFVQSHNSCIHLKAKEEFASPGSPCRTGTFCEGGSSCVNGVCRCSSGFRPEGNVCMSTNTYAFELCSIDEQCSNGFICDRGRCVCSNNVAQNNSACVLPTKSIRAKPRGSNCDSDSNICTGGSYCVHGVCVCPVGTQNFKGLCVPTTENESAYAPPGGICVDGEVLCTGNSVCANGYCVCPGGERILYVFFSCQLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI98</accession>
    <name>A0A0D8XI98_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000053766">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34195" checksum="9DB35F65566EB0D3" modified="2015-05-27" version="1">MKLHSLIFEPRKPSIVQFTDNLTMTDNIKTHDVGIDTMKRRSIGTQTEIDEKKPSTKGVIIQDECTSIPLAVCPSCSAWSIQGVLAVGDVAGNIHIVINDAVVSTTKVHLQFVSSISWISKTQFISCGTDGNVVILQFKGTSIETIKSVRLSVVDLPRNIRKSSTSVKSLSIVAMSRYDSEVCIGTETGGLWIASLPDLHLKAVPSIPQAIQSVLYMSPFIIISGDDESTTMINCDGSFVESIAIAAKHLCKIDDDLFIMTDNSRIVIYDKTLKKIMYDENRSAQCLTVTPLGDIVLLSENQLIALNLLKSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">DICVIV_09554</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716475">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="228" mass="26853" checksum="54F15B843DBA1AE6" modified="2015-05-27" version="1">MEITKSEIILVKERCLELESELRLVSRRKSELEEKIEELEHIIEQAAVSSSGDVTEVKLRERAAQCAVEGGLSRHEFDSLRREIEQKDRRIKQLEEQVEQTNTMHEQEQRLLTTAFYGMARRVDECSHLTEAIESTRERSFLSRQKQAHAFKLSLALPWLLVLLLVIYVMFGDARNPSRLAWWFLPIRLLVILYNFFYEILCNKCFQLHSSDSSYFKVNFCYVLSEIC</sequence>
</entry>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716526">
        <property type="protein sequence ID" value="KJH43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </feature>
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        <source>
            <dbReference type="SMART" id="SM00198"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="290" mass="32731" checksum="F5B167227C2062C0" modified="2015-05-27" version="1">MASLLLVLLTLAADIHHAIITSATQETMNCHDTNTNMNDSLRKAFLDGHNERRQTLLYGNPFPGRKAEELPKAKNMPLMTYDCELEKLAHETAKKCDNIGLSHNNFEYVGSNNMTSEDALFSTTTVDEAIGIWWNTLLSEGILVNLTPQENNLNKIPFLQTYDCELEKLAYETAKKCDNIGISHNNFQYVGSNNMTSEDALFSTTTVDEAISIWWNTLLLEGILVNLTPQPNNFNKIPFLQIANANTNKLGCAFYECNWNYDDITFLSITCQYGEPHIKIGVPIYEKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ71</accession>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="392"/>
        </location>
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            <begin position="576"/>
            <end position="649"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1647"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
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</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KN716649">
        <property type="protein sequence ID" value="KJH42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJQ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XJQ5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="84"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="257"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="12">
        <location>
            <begin position="508"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="636" mass="72266" checksum="138612931D01A0DE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJS0</accession>
    <name>A0A0D8XJS0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_10000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716510">
        <property type="protein sequence ID" value="KJH43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJS0"/>
    <dbReference type="STRING" id="29172.A0A0D8XJS0"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335721" evidence="12">
        <location>
            <begin position="34"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="113"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="501" mass="57089" checksum="C8DC779E4B0A7CAA" modified="2015-05-27" version="1">MLIPISGISLRFLLLKVVLRMISQSLQLHQVVGVQFRPQAIPLVPPHARAAVVMERALPSLANTILPLVHDSWPEDDNPIYSSTKETTATSLVLTKTMLVVFVVAMIIVTIVGNALVCLAVLLVRKLKQPANFLIVSLAIADFFVGLLVMPLALVDLLFSEWPLGRSMCKMWTTADLTLCTASIVSLCAISVDRYLVVTRPLKYSAVRTTGRMLVYIVIIWVIAAVVSLSSHIITNLLDTEQVENRICQVIQHFAYQIYATIISFYGPTIIMLILYVQIWRAAKRITREDKDQTKHIRIDIDKNINNHMDLISKTQTTTKIVKSHHRNYLHRTSALFQVVRVSLNRQNDGSECKARKTLGIIMSVFIICWLPFFSLAVLKSCLQLKVPYWLDVVTLWLGYSNSTLNPAIYCKYNNDFRVPFREMLACRCSTLQNEMRRQSFTSRYGPTVVMNCGYILCCKFCPVNEVNWSSQGFEFTQKIITEYIKLCSDHNNKIYWCTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKK8</accession>
    <name>A0A0D8XKK8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            </authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
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    <sequence length="123" mass="13967" checksum="38412B16C1D9A178" modified="2015-05-27" version="1">MMLDVNKRVYNHKPGPCRKVEGVEHGSEDIALIEDEGIAFITSGIFYMSPRGKNVKGQILLYDFKQKNTWKATPLRINGNHDQESIELFLGSTTKLILVSPPISTFVTFRHLTEKLFMDVGEK</sequence>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
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        <text evidence="1">Belongs to the GcvT family.</text>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
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    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SORTING NEXIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="14847" checksum="7CA000356E80FA9F" modified="2015-05-27" version="1">MFGDSASRNMSVQVKAEYDFEAQPGTGEMNITSGEILTVIRRNIEGGWMEGSNSRGHVGLFPQSYVVPYYGAPPGIPPDTTSSNSSEREYNQHWFYSLLDVNSHQKPNGQYSDLLVYSNFATESKPMVDIAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLQ1</accession>
    <name>A0A0D8XLQ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import receptor subunit TOM20 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translocase of outer mitochondrial membrane protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_09261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716454">
        <property type="protein sequence ID" value="KJH44704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLQ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XLQ1"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000004">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH44704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="14726" checksum="5FC88FEEEA53BF3E" modified="2015-05-27" version="1">MAAGLAGAAFIGYCIYFDHARRSAPDYKEKIRRNRREKAKARAGGPTTGRSGAGSSQVPDPTDSSALQAYFLQEVQLGEEFMASGNVEEGAIHIANAIALCGPSQQLLQIFQQTLPAEQYAAVIEQLPHTREITME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP35</accession>
    <name>A0A0D8XP35_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716403">
        <property type="protein sequence ID" value="KJH45512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP35"/>
    <dbReference type="STRING" id="29172.A0A0D8XP35"/>
    <dbReference type="OrthoDB" id="5867973at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="239" mass="26490" checksum="26830BF3C92E80CE" modified="2015-05-27" version="1">MSNQQPAWLNDRMFRGPTLPSNPIPNGPPARYADHTTGRRSRGSRTSEHRQASHHSESPPHTDVSYVQFQSSDGTGESSNGRLKQAAVAGRRSPPKHTLMDFIPPPPSNPPPSADIAYEDSSRRHFSRVPNADDPYDSVSDGQIFGDEMKVRQTGRNRTTGIRPQKGNRDDDSQRSSLMMDEEGVSSEPEGETSDCEARKRKTVPRMGVSASALSQNIYDCGRSTSRFKSIQRSKQDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPE1</accession>
    <name>A0A0D8XPE1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="680" mass="72014" checksum="41656E6DE16A2A18" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQU0</accession>
    <name>A0A0D8XQU0_DICVI</name>
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        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="KN716331">
        <property type="protein sequence ID" value="KJH46880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XQU0"/>
    <dbReference type="OrthoDB" id="5863201at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="10">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
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            <begin position="155"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="503" mass="58356" checksum="3241396898315C18" modified="2015-05-27" version="1">MDDVGDSIFEANYIQTEEKSTKESKNLSLLVDSELEKMLSDLEKEEWYHGCLPYEDIVGLMKSDGDFLIRALEPEGDRTAMACITAKWDGNVRDYPVHNLRTGEERLFTIDGLNKESNIMALVKRHHQQGIPIDKNVRLKKPVPKQRWELSSNKIKLVTKIGAGQFGEIWQGTMRENDKEPPIEVAVKVKKVNDENKEKMDEMYKEARLMRQYKHKNIVRFYGLVYQSGDKVMIVMELVNGGGLDDYLRKRKKKNKYVTIKEKIGYAIDVAIGLVYLHSKGCMHRDIACRNCLIDLKRNIVKITDFGLSKQAETYKIKGHERLPLRWQAPEVISTRTYTAKCDVYSYGILVWEIFNDAQQPFTGMDVKTVKSKIIDPKFRPPVDPRLPIVIQRVMRSCWRADPKRRPNMEQTARYLIYAPPKLTRKVPLFNQIDNRLVHITISNSSYKDRNITISIGFIDFIDLLAMFDTKHSTEINSESIRCNVVRMKIGVKFLEKHPDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQW2</accession>
    <name>A0A0D8XQW2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716329">
        <property type="protein sequence ID" value="KJH46905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQW2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="9352" checksum="B53D6CFE03285FD0" modified="2015-05-27" version="1">MDSNREEFELSDEELMIHSLSITHETFTRKRKNDIDLSDNVNRYVFCSYSSVVPPQCPLNFVNISHNNERVQPGYAKCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQZ6</accession>
    <name>A0A0D8XQZ6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KN716327">
        <property type="protein sequence ID" value="KJH46950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQZ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XQZ6"/>
    <dbReference type="OrthoDB" id="5799961at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011330904" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="166" mass="19483" checksum="1F5D698F2DC4924B" modified="2015-05-27" version="1">MIRFIILQTAFFLIHVNGQKLKKLKIDSPVKFEGDGTFGLCEDESGQMYYFREFENKGTQCQKNMAIIKYSNLINETGWAFVEVEVSTRVAETYKQGYVAGYIEGRTTRDLIRLHLSNTVEGYCNGAEQFCEDLTKYLIENYRWMQQNIASYPDNHYWIQVQHVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR28</accession>
    <name>A0A0D8XR28_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity phosphatase, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716362">
        <property type="protein sequence ID" value="KJH46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR28"/>
    <dbReference type="STRING" id="29172.A0A0D8XR28"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="294" mass="33271" checksum="432F2D22C3428CA1" modified="2015-05-27" version="1">MDNGHARKERMENYCTPHCARRIFYYNFPIHDFEACTAKRLLDIVIVMADELTKGKVAVHCHAGHGRTGMVITACLMLIHGVPPEEALQVVRQKRANSVQSSKQIRALCEFHRLFRKSASVLPDSPFSSTSLYMDFTNRVLPRIDARRYGKIPKFCSPKDEPTIKMSTTFLLLSMITCASLQGLTPDVSSFTVVSKNETEHLHQSITNNMAAMAVLAPNSQPWKLYPNTEVDVKAVIYVRQRCGLRSFDGIISTIPNSSHAERISALRIKKLNKYVYDWLSHHLNTIILHALTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR30</accession>
    <name>A0A0D8XR30_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ENTH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR30"/>
    <dbReference type="STRING" id="29172.A0A0D8XR30"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="52675" checksum="01636E7FECC2F37C" modified="2015-05-27" version="1">MSISTIRRQVKNVAYNFSDAQVKVREATCNDPWGPSTALMSEISDLTNNPMAFTEVMSIIWKRLNDSGKNWRHVYKSLVLLDFLIKCGNDKVSQQCRENIFTIETLKDFQHIEDNRDQGLNIREKAKQITALLTDEERLKNERTRFMLTRTKTTRNIPSYRFKACVIPAIHIHASPCSRFLEYIQSILLENLLDPEIEDARPSSIGEEEMQLQIAIALSKEEHEKIDEMMRSDEVRLQLALEESQREAERMAKMEPKTVNSKQLTQSALDDLLSLGVGEMVVNDQPSSSTTWANTGLIDPWAVLLSTEQQATSSTLYPSGQLVNNDPWVPSTGTTLVSENKNVTKSSSNNTQPDPFSALENQTSSNPASSSSTVTARKTPENFLGQNSNLVNLDNLLGVSSSTNSSCVNPFLLGSSSTTVNPFAVQQRKSPTLNEMRAAQTSAAPPIPQTGPRVGVLPPSVQPTQDPNPFVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRE8</accession>
    <name>A0A0D8XRE8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716316">
        <property type="protein sequence ID" value="KJH47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRE8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019426">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10323">
        <property type="entry name" value="7TM_GPCR_Srv"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="155" mass="18731" checksum="4D7112CF1C013A67" modified="2015-05-27" version="1">MAVCFILPCFIICCICYFCIHRLLHRHRNNTSISFKRQRRVFLQLTAIFVTFTMITVYHVMQFYFSYHQYNAVLRKMRLIHPLISCVLSYVSPWIMIITATDLRQKFRHIFESRKILRSIFTLKNVKKFSDVPTVNSKLYVFWTSTQSVRNIRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRK1</accession>
    <name>A0A0D8XRK1_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="7"/>
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        <property type="protein sequence ID" value="KJH45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XRK1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:glucuronosyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
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        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="533" mass="61036" checksum="651C351A97B730FE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRL6</accession>
    <name>A0A0D8XRL6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRL6"/>
    <dbReference type="STRING" id="29172.A0A0D8XRL6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="25434" checksum="4AF65597F0D8084A" modified="2015-05-27" version="1">MTSPVVFGTVHFYKAELNVILKSISFFTSQVSDLKIRNASVWCSLIRPVDEQLAIGWVIFVIRYRIPYGCAALRFTIELNKEINYNLWRCLCMLFDLFQVTPMDLHGALSALMRPLTTMQPSSTFPLTSFLQHPLMSPLTFPLSTNPMDSTLLDITVSDSQSTITPRKTRLESPSSPLSQSSTVSSTQLSSPQPSPIRKFAKPIPDEKKVNTAYNFYRDFYYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRV9</accession>
    <name>A0A0D8XRV9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716425">
        <property type="protein sequence ID" value="KJH45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRV9"/>
    <dbReference type="STRING" id="29172.A0A0D8XRV9"/>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF23">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="70"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25210" checksum="DE2D401147C2AED4" modified="2015-05-27" version="1">MDKPLLSVPPVCINKRKYPITSTQYVHLREGERKKLRTVNAKVDGVIMNTKGGGRCCAEIGDLGKKPIIECGHGKLSVNVTTEKLPPSHVFAKGHFNRPECSFRNVTHAVFDFEKCDINRKREVNPRGIAFTTTIIVQLHPLFITKVDRAFHVRCFYMEAEKAVGAQIGVNGHPRENQYSHQFQIYSKLPTRDEMFDFSERRIELGVISQFSSFGTTALEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS09</accession>
    <name>A0A0D8XS09_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716345">
        <property type="protein sequence ID" value="KJH46582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS09"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="9433" checksum="19BB115583AE3313" modified="2015-05-27" version="1">MFLSFLRSIQICFRLSFETYCSYGEKVFFFFLFFLCLLLSSLTHCKRCFIVLRCFSIVSSSFQFVIVLFFLLSSKKVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSG3</accession>
    <name>A0A0D8XSG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716340">
        <property type="protein sequence ID" value="KJH46679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSG3"/>
    <dbReference type="OrthoDB" id="10044505at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="48162" checksum="8A314343B6C8A826" modified="2015-05-27" version="1">MLLFASATTCKADSSFRIFEFRSKESGKTYNQYNELVEKTPIKEDVILVVAIKGNQTRIVKKLGKNMFYLPHGIYVDKKDYLYTTDVGSHTVAKWKINGDIWTRIRQILDMTVVDVSSAKRSAGSFVKPKTVNFNVAVLHHLELIWESGQKLQPGNDHEHFCKPSGVVEFGGDIFISDDLELIWESGQKLQPGNDHEHFCKPSGVVEFGGDIFISDGYCNSRIVQLDGVSGKRKNQFGMFGSGPTQFNLPHDVSISPNGHLLVADRENGRVQEFSIDGDFIMEWVSNLYTNIYSVDTYGSSIYMLPGRARDKSIQHEEGSTVLRKSLLMDSSRITPMATGTNGILISLVFAVVVVGSVVSSRKHGLLKKAKKSATFLSKKLSFPNHSEGFKPLRTDEVAGFISDGSDIPQFLIYQFGALLRIARFLFTIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSR5</accession>
    <name>A0A0D8XSR5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroendocrine protein 7B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 7B2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716335">
        <property type="protein sequence ID" value="KJH46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSR5"/>
    <dbReference type="STRING" id="29172.A0A0D8XSR5"/>
    <dbReference type="OrthoDB" id="9922675at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007945">
        <property type="entry name" value="Secretogranin_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738:SF0">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05281">
        <property type="entry name" value="Secretogranin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="150" mass="16843" checksum="73D10678990DC22F" modified="2015-05-27" version="1">MSLLPSGDFIDLISRDAESVPSPIAFGSKYITGGAGEGEQKLRDDENFQQRQEVKTDNVLPAYCEPPNPCPLGYTAADGCLEEFENTAEFSRNYQAQQHCICDQEHMFNCAGKAASDLEASLQELLDEHTLHRNMIAKKFHEKRNNEMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSV1</accession>
    <name>A0A0D8XSV1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KN716330">
        <property type="protein sequence ID" value="KJH46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSV1"/>
    <dbReference type="STRING" id="29172.A0A0D8XSV1"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
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        <location>
            <begin position="60"/>
            <end position="79"/>
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        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
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        <location>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <location>
            <position position="78"/>
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            <note>catalytic</note>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13972" checksum="9B7E2AF5EF65202C" modified="2015-05-27" version="1">MTNWFEYESGHAWCESAYKYQTLPMVAEFANTMTNLPIVVLPMLNAVMLRKYIREVNPCLIVPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIINMFLVVYIPVMKWFPKKFNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="88" mass="9806" checksum="B1ADF8FB750B3A99" modified="2015-05-27" version="1">MEIESTNLYSDQDFQSLDERQHWPTWAIILFVACVLLTVIAFILGNCITKRTAPLRFKGGAANKATNARVENRRMWGAGFSGGMWAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTJ5</accession>
    <name>A0A0D8XTJ5_DICVI</name>
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            <fullName evidence="5">E1-E2 ATPase</fullName>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJH47152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular potassium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular sodium ion homeostasis"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
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            <begin position="319"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="396" mass="44684" checksum="ADC32A4E7C807EF3" modified="2015-05-27" version="1">MTLKKYCESDCRLKHCKDLPIDLELGFFARWRRNDKVTPTKANISEARNDVGTSFVEHHLTIEQLKDLYPDSYIHHEFPERSDGLPTEEARKRLRDGGCNVLPPPKEESLFLVFVKQFHFKLWLLLTGAAFLSIAAYFAHYANGFNEPLNLYCAFILLLVVLFMCLISLWQEYKARKVIKNFIKLLPSKAIVIRDCEEKEINSEDIVVGDLVIIRSGSRIPADIRILQTNCLTIEMSEVTGQTQPVECTAEAAASYVSVFESRNVAFRGSYCTEGDGLGIVIRTGKFTVDIMLVLGGIANLHTQMMPAKSKLQQELRAITQFISVLAICMAAVMFFIGCIVAKFENVLDHFVIGFLVVIVANVPQGLPATVMSQLRIIARRMAQKNIYIRKLDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTM4</accession>
    <name>A0A0D8XTM4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LIM-domain binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="458"/>
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            <begin position="345"/>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="545" mass="60472" checksum="FD5D86BFFF103421" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="461" mass="50966" checksum="F21BC99AE5A25177" modified="2015-05-27" version="1">MRFLQLYDTSTLTPSVTVLSNSIDSRVVLDPIIAPSSPVNSNAPGHEPHPPAAQAAKTVIQSDEARQLPVISANSPETKKNIYKADPIPAKPDPTGNEGFPLVGPSPPMSVNYQTGEVRNRVNGIRTFQESSGRVTVEDSDLTEDEEVQRRNLLSCPNGLQEMRYSDGRPVMCLPGKNQCPEKSVCYFNGLDFFCCPNEEDPYDKHVFGGYDGEETKHGYKVFGPLNIRRLMDEVPLRTRRMANPRRSRREAASNTILRSAPESFNLDSIVAPLRFDDEKPRQVSRAQRMRSKPSPPNHGNPICVEPLSQGDCDSAHLRYYYDRETDTCRLFYYSGCKGNNNNFGSLNDCQKLCVLGGQRELFSLLILTLIDFPMADVIDKQSLYDLIFNSIGPRPQYQLTTSSSTSVPRGYCPDGTAPLGGSTPVLCGNSTDSIACPVGFYCLNGPPDVCCPYNKLEETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUT6</accession>
    <name>A0A0D8XUT6_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Deoxynucleoside kinase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">DICVIV_07794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716367">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26511" checksum="37456A58097A0D14" modified="2015-05-27" version="1">MTSSTPVMGRAFRRLLAIGNAVVKLPQCRSMVHKSLLRCCSGDLHNGTLLMMLPPDYPDPWPYKERGYNYSDVLRDRTKPHFHQNSKLIVVEGNVGAGKSKLAAELADHLGCYYMPEFKMEDILIDRYGNDLRKFYHLFPESFRMPDIDMFYKNPMSDMSAKMQQCIFECRFDQYLNALAHIMNTGQGVVLERTPYSDFVFVNAMRVKNFIGHELLSELTSVFTSMSLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUX7</accession>
    <name>A0A0D8XUX7_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_05523</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUX7"/>
    <dbReference type="OrthoDB" id="5856643at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12661" checksum="65DA5FC151934AD5" modified="2015-05-27" version="1">MLPHRAGYETSYYRMTLTLLNTSLPFVVRFKRKADVTMLRTLLIVLIAVLIAGYIVDARFLEDPYFLGSRVYADEPLQLVSAMLPKRAIRQVIENQPLPCRFKLCVTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVK2</accession>
    <name>A0A0D8XVK2_DICVI</name>
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            <fullName evidence="1">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_07549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVK2"/>
    <dbReference type="STRING" id="29172.A0A0D8XVK2"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="12778" checksum="CB92FD22DE177054" modified="2015-05-27" version="1">MDVKAQSTTRLKSPDDIRNVCLIAHVDHGKTTLADSLLSTNAIISGTIYESREDEQTRGITMKASGMSLIYGQMLINLMDSPGHVDFSSEVTAALLLSDIALLLVDVVGLIPTISCQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXF7</accession>
    <name>A0A0D8XXF7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic region leucine zipper</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716323">
        <property type="protein sequence ID" value="KJH47041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXF7"/>
    <dbReference type="STRING" id="29172.A0A0D8XXF7"/>
    <dbReference type="OrthoDB" id="5832747at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="125" mass="14700" checksum="97B9B97824E48479" modified="2015-05-27" version="1">MSGFYDATTQQNAFKAMSQMWQMDQYQQGYTTKDVPPSTSLPHPFANFAQQLSSITQTMRDSPAAPKKKSNPVPVEMKDEAYYERRKRNNESARRSREARRQKEDVNFRKLELVQQVQQSYVWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXV6</accession>
    <name>A0A0D8XXV6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716262">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXV6"/>
    <dbReference type="STRING" id="29172.A0A0D8XXV6"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="451" mass="50831" checksum="2C93A0E9C3A1FC6B" modified="2015-05-27" version="1">MKEIKEFGAWSEQTSSSGRKYFYNRDTEVSQWEKPKEWRDYEARIAEQERLAAEQERIQQQVHVQQQQQHAVVPPPPMFITPPPFAFPPPFAPPGFPVGPMNAPPPPFPPYNQFQPPPNIPYPIPPRISSTISGPINTSFVTFRIFSQHFLLKYGPIAPSPHVNTHFSPLHYSAPPPTTGVPPPLHNINQPIPAPPPTFTSVPSSCTPTPNRDSQVPHLTSGRVLQSPQTLQQQQNHVHSQFSRDRVPVEKSPRATPPSTRHNAPPPNVQQLAVPPISPSANKKEFREKHNEEQDDRLSPNRTYSNAGTPTRTGAVKRERTDSETNQEQTSVEVEDEKPLTKKTKEEDTATSWRSFYNADLARQKQIELNLEVDPEMRELLAQSLTLENKLVAKLIKMKTAAALVAVQENEACICNAKIQSLRDLRHELELRQSRLMAPAVVTMPDLNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZE7</accession>
    <name>A0A0D8XZE7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZE7"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20446" checksum="A820D452C3793855" modified="2015-05-27" version="1">MLLPGDNFQSIDIHKFVRFLIYRANGRATPLEDFIIVDVNDHAQYVKEHIITAEHFNRFTLSRNHFETPLLATARLQKRTLVIYGQSANMVTSTLHQRDYKAVYLSGSIPFFTTFYPKGLTTKTGDTIDIAALQESLQKKIDSDRGGRLWKSTSASRLHNVNAKNNISVSAKKHKIPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y198</accession>
    <name>A0A0D8Y198_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716270">
        <property type="protein sequence ID" value="KJH48371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y198"/>
    <dbReference type="STRING" id="29172.A0A0D8Y198"/>
    <dbReference type="OrthoDB" id="5871321at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48922" checksum="00C18B1A2EEACA61" modified="2015-05-27" version="1">MSEFREEKLLLKSEDLPLTRIENVTDILDWLLAGLPASSISYSPHRFGEKRFRKGRQELSHFQKHEDEAIRTVGGKVFNPEAYCNICQAFQKVTYDGSCLEMDLKPNRARKKKRVRIMTSQIVIAPTGYGSVASGDRIAMGVCEVWIVGIEQNEQVEIPVVIANLFESESSKICCLERKFCLISVNASLDSEYRPPECLKEFCNKYYLATHRAAKHGYCSQMLSSQSGVDLSALGRGADTAPSVDIQQLMMGLDQSTLTGNNALRSLYLSQMGMGGGSPSPSSVPSSGSASITGGSQDAGPEPSPKASTPTPQSDNSSGLPNWFSGLLPPQLQQQGLSSNMNTLLEQMQAMQSLQLFGGNIGSNVGALAAALSQNPASFLANSPNKKVLSSQSVNQTITITNDYNQGESQRFMRRFVSKFFLSDRPYVSRNSSDFANARAAKPELEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y236</accession>
    <name>A0A0D8Y236_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y236"/>
    <dbReference type="OrthoDB" id="5839337at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="407" mass="46924" checksum="BC22E70479322913" modified="2015-05-27" version="1">MMSVERLTCGFQEAERLKYRAKAEASIFSLYRLQSTISMMQLLIHVIYIWYNLSSYLFVIGLWGKIFRLGCLSSLNVEESLDCKTALSLSKRNATCIDTGSRRVCCCSPAMQCNSIWKPFLHLPHLNTEEFATIEWGFDLAGNGYDRLISIELSIGIIKVMIIFILLLSAWYPILPECQDHDEGVFEEKYYFIPQSMRSFVCHRAHTFVSTSATVFSIASVLLFALHGIELYRHEMSSRYCKLGRQFLRLAFCILLYILYAVIAIIQEVTPFFLTRKIDTSVDSVAISEKIMLNESFGEQLETAKSDTVVNGDDCLRVTPTPFILDSFGEGVLSLENLQPNEWITLRFSVGRTCPCVDVTRLWERPYIFPRSRWKFYVLPVYHESQDASDHEIMEDQRDLSKEHKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y257</accession>
    <name>A0A0D8Y257_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_03117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y257"/>
    <dbReference type="STRING" id="29172.A0A0D8Y257"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20188">
        <property type="entry name" value="T-box_TBX2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000016">
        <property type="entry name" value="T-box transcription factor TBX2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">HannoverDv2000</strain>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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        <source>
            <dbReference type="EMBL" id="KJH50297.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2H7</accession>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="19747" checksum="3D0133D7BDE96B96" modified="2015-05-27" version="1">MSTANDRAVLNHILNPLLPTDTSLNNTVENDAPIIANGIEESRRLEVEGVQLAENGEFDQAIEKFNEAIQKCPKNPSAFNNRAQALRLAGKTDEAMNDLDEAINLSNGFGKSACQAFIQRAMIHRLQGNEEDAKADFQRAADLGSSFAKMQVIALNPYAAMCNKMLSEIFTNLKEGKNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2L0</accession>
    <name>A0A0D8Y2L0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2L0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="10562" checksum="545342303F827D3D" modified="2015-05-27" version="1">MRRNPRSSDLSSKAEQVTEKGCIMRGLSLLVFLTLFNSSTFTASTTSSLVITQISVAMLNELHKLANYGRKIFEGNEFVGYFIYYHNGFLVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2L3</accession>
    <name>A0A0D8Y2L3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Small ribosomal subunit protein uS2m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_02906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2L3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2L3"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 14" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="13">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH50945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="837" mass="96321" checksum="396782986DE195C4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3M7</accession>
    <name>A0A0D8Y3M7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CUB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            </authorList>
        </citation>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="443" mass="48556" checksum="33578488A91861AA" modified="2015-05-27" version="1">MAVDEFKQTSEQHMRTLQFNDKVSRLNREFIRQLQEWYKECAHYDFSNSVKSYLEHIKRLDEMYFGKAVSKDVSNAPQKADRKIAKAKRRVADAPTNNELDTSVNISTSSNAPMQFSFGGATSATKPNKDDASATSAVGNSTSGNLSRKRAIRGGGPAGGAETIVFRGKDTSEVPVIKPIISNVLPKPTPGFWSTQKKDDCIGASKPAVDFGLSKKSDVSETHEKKTVSSPPFKKESLFFFEKKKDDGSESPSASTKTINKDEIEKKQTLSFPSFSSTNDKDKGGQKPTLTSFSFGNTTTSNAPSGGLTFSFGTLPKSSTEGEKVADDDGEYVPPKAEVVEVEEADAFFSTKCSVFKLIDKQYSKIGVGMLYLKEVDGKKSVLVRAATAIGTVWINALMNKTMKVAKVDEKGEKIRVRSILVTFMESQDSEIKPGYLHAIPYV</sequence>
</entry>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716196">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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    </evidence>
    <sequence length="127" mass="13790" checksum="DAFF4504B573269A" modified="2015-05-27" version="1">MTHPGSCACDPSSESALFSRASSCLPGSPVVLSPPPFPPSATALLAVVLLMVAAEADPLPPPLVAVIVKNIWTLDYFLSSIVLMRYHFVSIAISTFFYGTSTYEEIFDYNLPSNSSYTFYRKNSVNT</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="447" mass="50571" checksum="70D456B915F9F4FA" modified="2015-05-27" version="1">MSGCRECFHGDVNEVLGINQKHFHLHDFYCPTIHICYDSIFINLVVIIVKLSANMFTLRILCAIQLASIVTTEWEIPINISHYVLEVIAGYPTFIEYYYPAMNNQTVNDYPSHLPVLPISYKKLLNWTCNVFPGDDHTCVSTITAEKCRNGTQFSASYWGSTGSCEKEGQFVSCVNVTLINNTCRDVVIRIYNGSKVHLVLRDVHLPSSLTQSFIEHYSAKNKPMCYYTALPVIANQPLYVLGPGKNGNCGSKSNLVKYGLNTTVECSVERSVWSESHECPPMDKLKGFYISNVSHICNCGLCEVPLLLHPSPVIHYNSTSCVIPHRATLSFTHINGFINGAYLSYDYRTISDVENRIRISFRSQFIQYFEPCQKSRFELQRSRFYCPSDVTCLQELWFPLDDLPTSIISVIGCITVVVLVTIITMKQNHLTYFNCDCGSVLSKAKL</sequence>
</entry>
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    <accession>A0A0D8Y5H3</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716223">
        <property type="protein sequence ID" value="KJH49806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y5H3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008908">
        <property type="entry name" value="Sarcoglycan_alpha/epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048346">
        <property type="entry name" value="Sarcoglycan_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132">
        <property type="entry name" value="ALPHA-/EPSILON-SARCOGLYCAN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10132:SF14">
        <property type="entry name" value="SARCOGLYCAN ALPHA, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05510">
        <property type="entry name" value="Sarcoglycan_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Sarcoglycan alpha/epsilon N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="490" mass="55769" checksum="B5D154A0717C1202" modified="2015-05-27" version="1">MWSVAVSLLGTARLVVIHLYVFRSMVQRGSANAHLNSLYLKKIIETQKSDAKKGHLFVYTLHSAAFFRIPVDVTWSATLKNRPALPSWLHIVHSRYKAIAYLVGTPVTAARQITVHVFAKRLDTYELKQKYIVISMSEDERYTRTTRQLIDIYVTNFETEAIFSDRTDIIGQLEKSLKEAFRGKNVNPYIYSIKPGFQVPQGKEHLFHNQKSGSLISIGSQRGFYPNVHKLIDNLQTNPSFCRKQRLVILNKYFAPKFNVDWCQTRIRNVSTFHNSIEGELGKVHYDLEGVVRLEEVNATPAQPFREMGSIGEGYTFWESVLVFPLIAVFCIVLVLVLSLIFFGRREGQQWRDYKTPKEQLDEYVSVRESQRRLRELSVQRQLLLMAGEHGRTSPPFGVHSFLQPKHKTALNCFDSVARFGTSSTKLDANVEGATDFLSANDSIPVGKQTVAEAAKQCGSSLHLYRNPLESGTDEENENDSLDEKNITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6D3</accession>
    <name>A0A0D8Y6D3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable RNA-binding protein EIF1AD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6D3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6D3"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="19751" checksum="54E64A482AA02938" modified="2015-05-27" version="1">MSISTKRRYITNKVESEYYTPVDGDIIAQVRNARGNNLHEVLDENGEMYVVSMPSKFRKTVWIRRGQFVVLRPIKEGDKVKAEIEYVLDEENVLYIRSRNRWPYRFEEEARMMTRDAKRGIKQHAIIDDDMLPPSDSDENEENEEDLDDEDDSSVNMSISDDKNSTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6I4</accession>
    <name>A0A0D8Y6I4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6I4"/>
    <dbReference type="OrthoDB" id="5857248at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11514" checksum="0A1DBEDE4DF24C62" modified="2015-05-27" version="1">MTRGVKTMQKSELLFLIHAAILFIVLTSLITLWHYYDRLFPESIWLVFAINLYWMLYCGLNPLLYLIFSRKIRHAFLMLIRIVPPKPTTTVVRLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7M1</accession>
    <name>A0A0D8Y7M1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_00893</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7M1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7M1"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="443" mass="47969" checksum="F469AF1163FEE422" modified="2015-05-27" version="1">MVFICTISGEPAEEPVVAPSGHIYERRLIMKYIAENGVDPVSNDSLSENQLIPLKIGAVDTIPRNVAGTSIPSLLKMLQDEWDSVMLNSFSLRQQLQTARQELSHSLYQHDAACRVIARLTKELTAAREALSTLKPHAANVAHAGAGDIDMEQSVDESQGISEAVLARLDEKAKTLTAARKQRGKNLPEELIKQDEFASFRESACHTGIHSTGVPGITALDVQGKMALTGGADKTVVLFNSDKEQVQDVFKGHQKKINAVILHPNSKNAISASSDAQVRVWTTGEESCKALIDIHQAAVTDISLHATGDYVLSVSDDSHWALSDVNTGKTLCKVRADDNSSVAVCCGQFHPDGLIFGTGTADAVVKIWDLKEQTNVANFPGHQGAVRAIAFSENGYYLATGAEDGENIRDHKGLSAWFVRRILLLAQAVGFAEVEEFEDLEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7M5</accession>
    <name>A0A0D8Y7M5_DICVI</name>
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        <submittedName>
            <fullName evidence="3">Putative phosphatase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBM21_dom_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="361" mass="41060" checksum="1232B1AE4319B37C" modified="2015-05-27" version="1">MNMLIDIVVAVYQPIKHRVFPDYRCTFQGRAISLLATDYQYHSLTSMEETVLSLSDALSCLTIMSTKELNRKKLGLKLVSEKRSLYEYDSPSLYYSNPTDGEPISPDSGFSSDESGSPFVQRDTRSRTLPSALRCSQSKVCTKRVRFADALGLDLEIRQYFTEKESFSFPTQQTSATPEIRLVLSNFTYHSESECNQLACDEKVCLAKLTAHGRSLIGQINVANISFFKEVVVRYTTNDWTTFDEVAASYSHNVFGVHNVDAFVFSISLKSEMKTGQCEFCVRFTVNGFDFWDNNRGKNYQVKMEPKFSSPNLTFEVGPTVSSAPKTNSTFTPRRLRRWRRAQEESDDESSPISIPYRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7W3</accession>
    <name>A0A0D8Y7W3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7W3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7W3"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="85"/>
            <end position="412"/>
        </location>
    </feature>
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            <position position="114"/>
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        </ligand>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="646" mass="72516" checksum="CB957D03CE44D27B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8A0</accession>
    <name>A0A0D8Y8A0_DICVI</name>
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        <submittedName>
            <fullName evidence="7">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">DICVIV_01404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="59"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="167" mass="18741" checksum="66C38EF4785C4C90" modified="2015-05-27" version="1">MSWRSLWTKLYGKMRVSKWRKGKFGANCNFECACKNGATCDAVNGRCICAAGFTGPTCEDTCSTGFYGLNCSKSCDCLNNNMCDPITGKCLCVGWMGEKCERGCPKGYYGPMSIINILVRTCYFEMNLKWVKYVLLMGIGAYSKTENRRVFRLIQLATDFSAKKCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8X8</accession>
    <name>A0A0D8Y8X8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium:neurotransmitter symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716154">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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        <location>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
            <position position="567"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63852" checksum="38C67799D78764A6" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9A6</accession>
    <name>A0A0D8Y9A6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716162">
        <property type="protein sequence ID" value="KJH52579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9A6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="83" mass="9330" checksum="EAD52620BA422D90" modified="2015-05-27" version="1">MFGATITVFTFASAITTVLAKWPTLRDLLKPSEQLAFRDTLSHLVEFEYRNNAINSDDSVLSKSTSLFPTINQLNSNYSEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9C7</accession>
    <name>A0A0D8Y9C7_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_00458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9C7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9C7"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
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            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="222"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="288" mass="33226" checksum="54F34034DAFBC724" modified="2015-05-27" version="1">MLCHRPSGLQLLSYFLTFLLLPITCFSSVSFSFPIGTIGVIVGYVIVYAQNIFLTFYDISPDELIIRKKQGIKPVDFDPKRHEHVIENGFCNICQIHVKENTKHCRQCNVCVEVFDHHCIWLNNCIGKKNYKMFVTLIFTIVVLSSGVTLLSLWQIFFCIYNPEGTRKSIAQILPSRIPMWIFLLTSSISFASHFAITATTAHLLQFHIKLWTKGITTYRFLLDQRQKKNHSKEMISVRDVTLQRISSEVPQTSNLRGILTPKISDVHQQLPSYMQTEENTEKRPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9G4</accession>
    <name>A0A0D8Y9G4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_01100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9G4"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF269">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH52639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="21768" checksum="A621131B90C5E28D" modified="2015-05-27" version="1">MFASLFIYLYDALSGPPGSGMDFFHSFYFSFISMTTIGLGDIMPNNVTFAPIITVLFFFGMPILKVVNRSTYICVENGVFGTLTVVENRLDSCWTGVQPVDIEVQRGPSRQSTRSQRSDTDEPNGGSSDEENQASQLLNNFTIRSIATFMKSHSDVYGGDFGRVNLRRGDLLPQNNDNMRSMSVSSSGRRPTHVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9Z7</accession>
    <name>A0A0D8Y9Z7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9Z7"/>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF1">
        <property type="entry name" value="SODIUM LEAK CHANNEL NALCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="173" mass="19659" checksum="71180FEA076AF056" modified="2015-05-27" version="1">MHSSVIPLPVCKLLDSVSPVDIARPAAAPSPTSLDGGEDPAFTPEQASPTEQRHVNFRTGSEALVVLFRSITGEDWNDIMHDSIIMENFSLFYSSEEDALLSYADIRNFQLVWNMVDREQKRSIPVGRVKFLLRLLKGRLEVDPEKDKILFKHMCYEMDKLHNGEDVSFHDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAR6</accession>
    <name>A0A0D8YAR6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAR6"/>
    <dbReference type="STRING" id="29172.A0A0D8YAR6"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000169">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="338" mass="39729" checksum="9437ADE648A8DAF7" modified="2015-05-27" version="1">MSKRRCITKGVAFNVLRELSFLRRISHPFIVNLWYTFQVLLLNNVNNNRLMILLNLFYDFLLFHDRDYMYMVTDLLLGGDLRFHLNQQGKFAEDRSKLYMCEISLAIEYLHEKRIIHRDIKPENILLDEQGHAHLTDLNLATQLEANELATSYSGTRPYMAPEVYACALGLIDGYDFKVDWWSLGVTFYEMMRGRTPYEFSHHYTAEQALLMIRESYVPFPAHWPTDLLNFLRLLICPSPEERIDSLATIKRHPYTARIDFSHVLARRAAPVFVPCKEGLNCDPMYELEERILVSTPIHRRRHNRKHCDDNEALREISQAFIDYSRDEAHSLVNGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC56</accession>
    <name>A0A0D8YC56_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Memo-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC56"/>
    <dbReference type="STRING" id="29172.A0A0D8YC56"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="308" mass="34751" checksum="D14750FD3D6EFF30" modified="2015-05-27" version="1">MKMSSNGYGHSHGMIRAASHAGSWYSSNSRELDRQISRWLDAAGDRIGAARAIVSPHAGYSYCGDTAAYAFKQIVPENVDRVFVLGPSHVVCLNGCALTTCSRYRTPIGDLHVDMEVNDELRATRQFDLMDRSDEEAEHSIEMQMPFIAKVMENNYNVTVIPILVGSLTSPKQQAYGKIFANYLENPRNLFVISSDFCHWGNRFHFAPHNPNSGVPIYEQITQLDRDGMDAIETLNPQTFNDYLKRTQNTICGRNPITVMLQAAEHFRMMNNHTHEFRFLKYSQSNKARSVNDSSVSYAAGALFMHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YE99</accession>
    <name>A0A0D8YE99_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase HDDC2</fullName>
            <ecNumber evidence="7">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HD domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
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        <text evidence="5">Belongs to the HDDC2 family.</text>
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    </dbReference>
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        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
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        <location>
            <begin position="8"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032735"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52951.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11625" checksum="05FDFFB43AD5A735" modified="2015-05-27" version="1">MNPIFVFVVLNWDCGLENLAKGELDRAEKATKDFPLSDVAAQYYTLTSKGKNLRSALAKIPPLFLEDSRHFLQWLMPVGCMMRFSMSEDNLYTVLSRKRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5A4</accession>
    <name>A0A0D8X5A4_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721572">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11549" checksum="56255EA9ACE0A0BE" modified="2015-05-27" version="1">MGINDVLIPLHSGDVLLASCQDRQLRSYSISGKLLTTVRGTGGEADLQQGSLEKFCLDPSETYAASVCSDRHVYVVEIRSGKCVAAITGIGESATDVEFSEDCRSSVY</sequence>
</entry>
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    <accession>A0A0D8X6N3</accession>
    <name>A0A0D8X6N3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717617">
        <property type="protein sequence ID" value="KJH40185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6N3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="21499" checksum="F354A402145D86DE" modified="2015-05-27" version="1">MLYYIIVMFITIIDNIVVNPMIFDVNVSSNHERLKSLQSNSVANSDSFYIFTTTYTTPQLSSKKKIKRKLERNPRLIKSRETLKSISKSSDTFLTPANINVLNLPADKYTRTNRYRRSISTIPLYKSMEEISQMAKFTTIGQIRQYLLKEANIVQINPLQFDVKKFRDEVNHTGPTTKAYNVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7F8</accession>
    <name>A0A0D8X7F8_DICVI</name>
    <protein>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717188">
        <property type="protein sequence ID" value="KJH40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7F8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="69" mass="7349" checksum="3CF7212E6D7B8646" modified="2015-05-27" version="1" fragment="single">KTINFNLTGFDLPAAMVYSPEVTAPSVAPTISTTETAAASLVRVLVDGSLMFMKVYICINKNVVQRGGQ</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="KJH39619.1"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="101" mass="11136" checksum="BFCFEE04795DDD49" modified="2015-05-27" version="1">MMGAMLVIVIMHVQIERKAVLFGMIGSVPGLVVGFNFLDPLLDAAQKKMLFVSIWSSFAIALFILNSQKKRTTYKLVVDFKLWKATVLIATGFVGGEKTGK</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
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            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KJH39747.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="49" mass="6192" checksum="38DC903587FB0959" modified="2015-05-27" version="1" fragment="single">DRAERRKEQEKRRLENERKGEVVQVIRKSEKVRRTKKKQLRYIQKRDVN</sequence>
</entry>
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    <accession>A0A0D8X7N1</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722087">
        <property type="protein sequence ID" value="KJH39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7T0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="80" mass="9096" checksum="E1D073545DE6C39E" modified="2015-05-27" version="1">MVAKFNNVKLFSRGRIRGKPPTPPPRERSRSPVRSERATPGFESHNYRSHNGVHEPNTHDFSNLSSIVHVSDHISFSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X952</accession>
    <name>A0A0D8X952_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ligand-binding domain of nuclear hormone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716899">
        <property type="protein sequence ID" value="KJH41120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X952"/>
    <dbReference type="STRING" id="29172.A0A0D8X952"/>
    <dbReference type="OrthoDB" id="10006908at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="329" mass="37273" checksum="44B601096809303F" modified="2015-05-27" version="1">MPGGRNGSAIYSIYKLRCRKTGRHVVNCESTTSCESASDGIIRLKENRADYDEYPRPKCKNLIQELIEIDQIDKLINLRGLRIAPLSDSREEFAPACQRLSRIGDEIVEQLVEWTKMLPFYCELPVEIHTHLLTQRWAELVLLSACFYSCSTSNLSNDETAVSTTTIDGNEEVSFIDPSVNILLLQKRLSAVMGKPIPLEHVTKEAGPLVEKFTALLYSFSKMRITPEAYVCIKAITLLHYNTEGTDANDEKSAFVRKVTLIQDQFVKALQVHLIQNEEGARLSDILTWLPMLHNASSVLLHSKMFYVPFLICKNPHRFAGQDDYSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA22</accession>
    <name>A0A0D8XA22_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="KN716824">
        <property type="protein sequence ID" value="KJH41440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA22"/>
    <dbReference type="STRING" id="29172.A0A0D8XA22"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="23090" checksum="E2E6EB16BCC9129C" modified="2015-05-27" version="1">MATHTTMPRNLSYSKVARALAGEELNDREVLPLDGGISAREEGRIVFECAWEVANKIGGIYTVLRSKAQISNEELGDQYCMFGPQKNDKWRLEVETIEPENRQEYPIDINNFQYGYPKVILFDLGSGAVHMNEWKQELYDRCKIGIPYEDIESNDAVIFGFMVAMFLRNYREAITEYQPLVVAHFHEWQAGTFSCFLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAA1</accession>
    <name>A0A0D8XAA1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PKI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716807">
        <property type="protein sequence ID" value="KJH41525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAA1"/>
    <dbReference type="OrthoDB" id="8556393at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18240" checksum="5DE97415E7C520DC" modified="2015-05-27" version="1">MGELESESDALEHFVASGRAGRRNALPEIEMETNDPGAVKLADRLSDLSAQCDENVDVSQRGDQHDMTIEIVTETEWVSGKIRILTNFLVENNIFDENSQRILQYPLKGDQKLLSINKVITFIPDLQNTFRSSCIDKINYSIKNTTQMSVSASSTESLTNLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAH3</accession>
    <name>A0A0D8XAH3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_13396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717070">
        <property type="protein sequence ID" value="KJH40644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XAH3"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="260"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="378" mass="43833" checksum="9615CBDA5A35F440" modified="2015-05-27" version="1">MTRKRRSASENRKKEFLRKTNEIDDDALTCGKTENESTKAAQSGTASSDNRSKWSTMIVETKVPIKVLSKEFAKHKSYKPREYTTNAYDKNEPKNRYRYHFTKAYAGFHSSDFRYNDIICIDATRVILKDRPADDDYIHASWMTMPDQYKYICTQGPLTETLNDFWHMMFCERSTVLVQLCDFVEGKHEKCSQYFPKSKGSTESYGPYKVTYMEAKSDPFESVKHIVLKLEAKGHTITVNHFAYLIWPDHTAPFNPASMAGCLKLCRQLAESHPITVHCSAGIGRSATFIAIDYAWQKIRENGDWQMVEAIKDLRKQRFHAIQSPIQYIFLHMCVLEMAAEENLLNRKSKFAPYLEAYTTMLRKYNKKVAAAENRSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAN8</accession>
    <name>A0A0D8XAN8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717004">
        <property type="protein sequence ID" value="KJH40822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAN8"/>
    <dbReference type="STRING" id="29172.A0A0D8XAN8"/>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051295">
        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF318">
        <property type="entry name" value="LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23909" checksum="C4D392CA8DE3B25C" modified="2015-05-27" version="1">MYSSIYALYIIPNNMHNISLRRLRSDMFLQLIIYNDYKLQVVLIQRSRISLLNTDAFSGLSTVETVELFNNEIGTIGARAFASIVNLGRIRIARNHIQTLQTVESLLSMAIQTRIEENTIDCGCDLQWMTAHQDKILPDVNYCGVEGVHRTIRSFLRQKCARTTPTSTSSSPFPVTNHERHINTAENSAQYNLFYCHSTIAIIISVIQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB20</accession>
    <name>A0A0D8XB20_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716946">
        <property type="protein sequence ID" value="KJH40972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB20"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7489" checksum="182E36BF40D23C46" modified="2015-05-27" version="1">MPLTLDSEVPLTADIIIPSEYVPMYPTKTLRFTQSDIGLSSSFAQLVFIFTYLSSLKAKGKFENDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBR8</accession>
    <name>A0A0D8XBR8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_12919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="KN716903">
        <property type="protein sequence ID" value="KJH41109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBR8"/>
    <dbReference type="STRING" id="29172.A0A0D8XBR8"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF27">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH41109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="15978" checksum="079EC91360C1C346" modified="2015-05-27" version="1">MKSYCRYHHVLTMNYAIISYSHDIAFNSWITWMNFTVHSIMYGYYMLRSYGVKIPAWIARNITTLQILQFIITHLILFHVGYLTSRGIPVDSNTKIFWGCLLMEISYVILFGNFYFQSYIKGGGKKFNDEKSKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC05</accession>
    <name>A0A0D8XC05_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_12746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="EMBL" id="KN716860">
        <property type="protein sequence ID" value="KJH41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC05"/>
    <dbReference type="STRING" id="29172.A0A0D8XC05"/>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="11">
        <location>
            <begin position="116"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="555" mass="62562" checksum="103A36A60B7B9884" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC54</accession>
    <name>A0A0D8XC54_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14024</name>
        <name evidence="4" type="ORF">DICVIV_14273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719984">
        <property type="protein sequence ID" value="KJH39832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KN718199">
        <property type="protein sequence ID" value="KJH40061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC54"/>
    <dbReference type="STRING" id="29172.A0A0D8XC54"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH39832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="60" mass="7099" checksum="99F5920D83AEF740" modified="2015-05-27" version="1">MSYRALYKYTPTKSDEVSLEVNDIIFVVEKCEDGWYIDKKNKLLFFDSGIKEDKARITIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDD6</accession>
    <name>A0A0D8XDD6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eyes absent homolog</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="KN716643">
        <property type="protein sequence ID" value="KJH42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDD6"/>
    <dbReference type="STRING" id="29172.A0A0D8XDD6"/>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="102" mass="10835" checksum="9A57DA28E8E2CD22" modified="2015-05-27" version="1" fragment="single">TAVSTEKYANVVLCTDPLVAAIAQILLGGLAHAVPIENIYSISKTSREVVLDRIQNRFGKKCSYVVITSSLETNNIARKSFSPATISETSGIDSGLAYSDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDJ7</accession>
    <name>A0A0D8XDJ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717155">
        <property type="protein sequence ID" value="KJH40516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDJ7"/>
    <dbReference type="OrthoDB" id="5831187at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16261" checksum="ECF8971AECC0048E" modified="2015-05-27" version="1">MEIRDTLCDLGRMEIPRPQFYGMQFVATRGKQGFYKTIRDNGSKYGIQVKAQRSRRPVLSNDLFLRPLNMEEKIAEDRHSTSRTKPNNTDLNQYTQHVNNSDSRNKSICMELEPDYPDDYIPPHTYSNKNSKSHKTSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE04</accession>
    <name>A0A0D8XE04_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="7">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_13375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="7"/>
    <dbReference type="EMBL" id="KN717058">
        <property type="protein sequence ID" value="KJH40666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE04"/>
    <dbReference type="STRING" id="29172.A0A0D8XE04"/>
    <dbReference type="OrthoDB" id="188713at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="13">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH40666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="308" mass="34261" checksum="FF15DA208CDE4242" modified="2015-05-27" version="1">MVMDGAGIRIGAVANLHRIKDAARLALAVMNYTKHTMLVGEAATKFAIEMGFKEQNLSTTFSSEMFSEWKRNKCQPNFWMNVEPDPTKTCGPYRPQNYRYSSLQRNVEIINRFHHDTLGMVVVDSNGNVSAGTSTNGARFKIPGRVGDSPIPGAGAYAVEGVGGAAATGDGDVIMRFLPSFFVVEQIRLGTKPFKATRKAVNRILEHYPHFQGAVVGVNSNGTYGAACANLGSFMFSIGEHGKTRTELVACINKKNSFKKRKKTKHNIVFYKLFSYKYFYRSLHFSKHRTVSVSSCQFIDKKFQKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="7">HannoverDv2000</strain>
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        <source>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716812">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34162" checksum="C938AA4E9A435A6A" modified="2015-05-27" version="1">MLRLTRELKHQSISRRGDSSEEDDLSIGRRRSARLNPKLEQEFIRDSGTESDEDELEEIARSEYSITDEFIRDSGTESDEDELEEIARSEYSINDVRIESFMENSMETSLTESPPILSSSPPTASDIDTESWDSFGHESGIVTGDGDSTSDGDECPTPKPRRRMHDGAFSKMKFPKVKCEFPLLNVCGTIDKRRQCNTAKKDSGPIASRLRSNNDSSREIIVAARRAPVRLLINRPYRRTKGSAVSSESTPTTSFCESYCPVPKKSRSNSWRPCLDLEKMIRNRISSESARATTKSDCCIQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH84</accession>
    <name>A0A0D8XH84_DICVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_12333</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716778">
        <property type="protein sequence ID" value="KJH41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH84"/>
    <dbReference type="STRING" id="29172.A0A0D8XH84"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="167" mass="19004" checksum="35B3EFC692F695BC" modified="2015-05-27" version="1">MLPRTQKESYENIDYSLILMTPSVWCRRCDTSDYDFAYTECGADGSRWRVALSYHPGACEGLPEPKKGLNCYRNPSGCRLNKVSCQFLDRNRPLCIRSLNPKILATSLKEIKRNFCKYDVCEYVKMTITFTDILASSDDVGRKCIPLYELVAVVWITGSSAPMLQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI06</accession>
    <name>A0A0D8XI06_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60S ribosomal protein L5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_09744</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI06"/>
    <dbReference type="STRING" id="29172.A0A0D8XI06"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
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    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="10">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH44233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="34220" checksum="826A984994065CCB" modified="2015-05-27" version="1">MGLVKVVKNKAYFKRFQVKLKRRRQGKTDYYARKRLTVQDKNKYNTPKYRLIVRFTNKDVIAQIAYSKIEGDVIVASAYSHELPSYGIKVGLTNYAAAYATGLLLARRHLKNLKLDKTFKGLDEVSGEFYTVEDEKGRRPFKAVLDVGLARTTTGCKVFAVMKGVADGGINVPHSENRFFGYDVESKKYDAQAHRDRILGKHVAEYMRSLWNDNIEGYKRQFSKFIACGVTADSLEEMYKSAHAAIRANPERQPKPAKKYGEQKRFTAKKITLEQRKKRIQQKKNLLLKMKEQQEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI08</accession>
    <name>A0A0D8XI08_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716566">
        <property type="protein sequence ID" value="KJH43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI08"/>
    <dbReference type="STRING" id="29172.A0A0D8XI08"/>
    <dbReference type="OrthoDB" id="5810331at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="29240" checksum="83D8166B6389BAFF" modified="2015-05-27" version="1">MSKSFLVITALILTCDTKLEQKKLYSWMENQVLLSVSPKNSTLSLTSSDDIPEVPQPFILNTALKTPQYRINSTEDEVITDEDVAGDDDESTKVNTAHYDGKKTTITISTEAGIELYQHWLDQAVSGLMAAIATEKLARVSDIQKAAHNTCTKSATTVQAHAKCVVVLLDIEQKYQRWTAKFGNAKRINMKQSWMTKGKSLKRFEKQHWRKSPRPHSVERKPFPTMQGRSKWSMKRNGNEVANRSAGKVSITGILEELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIW9</accession>
    <name>A0A0D8XIW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716465">
        <property type="protein sequence ID" value="KJH44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIW9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="62" mass="6977" checksum="5C6268453E7E9D35" modified="2015-05-27" version="1">MYMLPGRKQRSSVAAVRKSSERFRAGFGGGMMMNASAQQKRSVMMFRTFSKAPIRNGCTNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIX8</accession>
    <name>A0A0D8XIX8_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Serpentine receptor class alpha/beta-14 family protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ORF">DICVIV_09367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716460">
        <property type="protein sequence ID" value="KJH44615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5825748at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019408">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053286">
        <property type="entry name" value="Nematode_rcpt-like_srab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561:SF11">
        <property type="entry name" value="SERPENTINE RECEPTOR CLASS ALPHA_BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46561">
        <property type="entry name" value="SERPENTINE RECEPTOR, CLASS AB (CLASS A-LIKE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10292">
        <property type="entry name" value="7TM_GPCR_Srab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="272" mass="31291" checksum="0907BB4AA1FDDEC3" modified="2015-05-27" version="1">MRVIHCMKRNGVPLQVVLSIYATLCGILILAVERTIATLKYKSYEIHGSKIVAIILIAAQWLLSFFFAILSVLVRSDPGYVHYCTVYVSHPRTAVFSLCVMSLLEAVALVYFVVLLQSNQRRQVNEFVNNAMHTLTERYQLQENVRIMRILIPSITVHAVLGMLGLISLLIFAIIHRSVEERIVVRFAPFSELVLLVVPVYAVVFPFVAILRNKQLWQASRRALPYFFNRRTIPPTDEELISDPANMVSRPSRQMQRDSAMHFDMLQEMWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJL5</accession>
    <name>A0A0D8XJL5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transthyretin-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716506">
        <property type="protein sequence ID" value="KJH44029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJL5"/>
    <dbReference type="OrthoDB" id="5905679at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335825" description="Transthyretin-like family protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19371" checksum="5D71CB100D6AFA07" modified="2015-05-27" version="1">MQILGLSGIGINLMWICFITISLHGSVDSEGGTADLGYTLSRCPEYEFGEDLAVYDILILSRLNRSNLDVGRMLSIAPLKGRRSNNGLRTTFIGVEPRYAEGEIIVFICIFTDAKQRVNDNPEYMEFVYGKHRKLWDIAKSGTGLDFGNFYNRNPISIESVSVEFTALNKTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJL6</accession>
    <name>A0A0D8XJL6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716654">
        <property type="protein sequence ID" value="KJH42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJL6"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="9769" checksum="A5E0F1AF83A33650" modified="2015-05-27" version="1">MVSVSHPSAPLRDGIVRVHTHPSLLVISPSGSDTKVTSIIQAELHLMGVPTGIADTLVPWGLTKFFDDLRSYSARDLKLNYDQKLTGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJP3</accession>
    <name>A0A0D8XJP3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EIF3F/CSN6-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_09139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716445">
        <property type="protein sequence ID" value="KJH44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJP3"/>
    <dbReference type="STRING" id="29172.A0A0D8XJP3"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF3F/CSN6-like C-terminal" evidence="4">
        <location>
            <begin position="302"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="472" mass="53513" checksum="D60FDF76245AC61B" modified="2015-05-27" version="1">MIIRLSGFPSCSVAVTQRIRTFSTRAENELRTEAKDEHHHILDISGLKARHRVIAAGGMPPLEFNWERQRKGQRERFGIYGLKSGIDPSICWPTVEEIEEEQAVGLYREYETCIREMKVLKQSRQAEEVARIEELENNLKNYPDKLAKYEMTLVKAEKERDAKEIALENRIREIQEYFGYWIDPNDQRFEVMLRQKEEEEKKAAKMARRAELQKKTIADVFPELDVVGWYCTGGDGLEQSEILLQSLFAAAIDSPLIVKLDPTADSQSRRNVPVKVYCGRETLVSTGHSLVELDWTLVSEQSERIGIDHITRLSQAGDDGAVSSEGKQMRAVGSAIGMLLDRMEIICKYLKGVEEGKFLANDEIIRETNKLCQRIPLLKPAEFDKRFNMQERDARAAMLLAKMTETCGTLSSLQAKTNVLGTVTAWRSFVTFPTQQPKKKISQRSTGSGNSNPVLSTDLSVNNDIAHSPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKE6</accession>
    <name>A0A0D8XKE6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716431">
        <property type="protein sequence ID" value="KJH45045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKE6"/>
    <dbReference type="STRING" id="29172.A0A0D8XKE6"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="430" mass="48209" checksum="0F4F038227314B54" modified="2015-05-27" version="1">MKSRISRRFAFCRDGRNAATAVRAVPTRAFLSNSPTTVIDMQYNVGDHVRCMWGLKPVEYEAKILHTNSATKEYFVHYQGWNKRYDEWISERSILGISKKSSTVVCDTPKTRQSKREKKTRKPLDWSPTPTSSRVAEKPVSVKADCKKLIGPVRVTKYKRSPILKTSKQSRLQVSTVANDSTEESVTSDDDDADCTQFPRSYIDTLVKQKKREERKRQKRSSPKLPGVDLIKTWKLSLPRNSSDTLTATLLPIMDVGKSSTMPPMVPRIPVECHSFSNIEADHNYSSLTFHYSDAYSLNAIREQSHASQLKSSTKRMNILPLRKPLNVQYRMPCSTTLKLYTEALSMSFKNRHGLGNPSNLGAPFSYDDEYHSSLGTPIECNNEIDVSSLSNKHVSDSGTTSSSSSESGECSIGHTALTQKSVSAFTIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKK6</accession>
    <name>A0A0D8XKK6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716615">
        <property type="protein sequence ID" value="KJH42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKK6"/>
    <dbReference type="OrthoDB" id="5850775at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="36689" checksum="5A8E845B99C14F59" modified="2015-05-27" version="1">MYTRSFSFAVPDEVFDALVPDVMLSPKFTDFRLEPEFLKFLRSSFFRDNFSVPFMKKCIRFAIFQHIFTNPVQNVKKEIGGSFINEVETYMGVLDFLHTNLYSFYDKVPVRNSLHILQLHENIQTGRFLCDIRGSDGYKNWMQLLKNMSNEDISNLIQHQGIAAYRVQLLSKFQNQLMEGNVPISRKLCETRTSSLHLKSKVEEIILAQQCNPHALARQKMLSEIENIFRSVLRPFSSFSYSSHFLLGGKSIKSLAPNIVHDIETVLVLQPVDMLNIAVQALVKQGKWKTVELSKWCETFIAELSLRVCKFIKVLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKL1</accession>
    <name>A0A0D8XKL1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Malonyl-CoA:ACP transacylase (MAT) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716486">
        <property type="protein sequence ID" value="KJH44277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKL1"/>
    <dbReference type="STRING" id="29172.A0A0D8XKL1"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="1">
        <location>
            <begin position="107"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="263" mass="29335" checksum="F7D937CC494E1A76" modified="2015-05-27" version="1">MHRNRIPFMTLKRWIRKRVALEQSKTSGSGILDEGATFSDVHSVVLDPTSKLPYPQKWEGLHVFCLSEHKAQQPTQILRSFRYRNKKKSTNAIVFDHIPLQEQIVCLFPGQGAQYVGMGSKLVDCAKAKEVFDRSSEILGYDVLKLCMQGPKTKLDQTLYCQPAIFVSSMACVEKFKASDETIADRITDAAGFSVGEFSALVTGGILKFDDALRVVHARAEAMHECNQLVRSGMLTIKVNASSRLGEAMYDAISISRSFCFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL09</accession>
    <name>A0A0D8XL09_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Death domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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                <person name="Choi Y.J."/>
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        <name evidence="14" type="ORF">DICVIV_08239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716391">
        <property type="protein sequence ID" value="KJH45705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMG3"/>
    <dbReference type="STRING" id="29172.A0A0D8XMG3"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="239"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH45705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="325" mass="37551" checksum="E63083966CCB82B4" modified="2015-05-27" version="1">MYSTDNKDEQCQNSLNKIYSDLLHLICSFEKGSGSELTVRLRQVESALEQLRESIRSIPDIQNNEQRQRDRIASLYRQIKLKDDLIQSFVHYDIVDGSERSVFIIHLSFLCMYTICQLKMCCGLQESTSNVIEGSSNKHRLVCGVCGSVVLLAGAGRWSNRNMVLPLCRQEKNLSIQKEAVSGFWTVEDMYDFENVGFTNSAEDFSAKVDCVTSKTLWQKRKRSHRLFFFKMLSSTVEEPLDLIKLSLDERVYVKMRNDREIRGRLHAYDQHLNMILSNVEETVTTSEVDEESFEEIYRQTKRNIPMLYVRGDSVILVSPPVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN55</accession>
    <name>A0A0D8XN55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716376">
        <property type="protein sequence ID" value="KJH45975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN55"/>
    <dbReference type="STRING" id="29172.A0A0D8XN55"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="891" mass="99065" checksum="1DAC205643C1547D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNJ0</accession>
    <name>A0A0D8XNJ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716368">
        <property type="protein sequence ID" value="KJH46120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNJ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XNJ0"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <sequence length="63" mass="7176" checksum="8FAFE9709D439083" modified="2015-05-27" version="1" fragment="single">MTFFNEFYPFLYLNPQHKVRSVVVGNFVAQSITNNSMLPVCNYSLRKHSLNGPPVQKATIGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
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        <source>
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    </evidence>
    <sequence length="151" mass="17031" checksum="0285638A32AB9B3A" modified="2015-05-27" version="1">MCYVWEGRWNGAVPVAVKKLKSGAADPNDFLVEAQIMKKLRHPKLLSLYAVCTKEQPILIVTELMQENLLAFLQNKGKLYNVVHLVEIAAQVAAGMAYLEEMNFIHRDLAARNILTKSNLNVKIADFGLARLLHQENQYEARAGARFPIKV</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
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    </dbReference>
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        <property type="entry name" value="Motile_Sperm"/>
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        <property type="entry name" value="MSP"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="409"/>
            <end position="427"/>
        </location>
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            <end position="156"/>
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            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="472" mass="54928" checksum="4B16146B107257D8" modified="2015-05-27" version="1">MLLWINFAQYRPGDTGFENVFVFWLERHTMETKGTPLTILLDMSGTSMKNMDFNIFKFIFHVLKYYYPDIVHDMIVFESPPILNASWKVDILRFLYSFIKISMKEFLIQKICVKIMKSWLDPAHPQIHFLTKDTITRHVDKKNLPPHMGGEDNFKFTMDDLVKCLPASQQNGNHSNISDGEYCMDRDGFDSFMKKGVTFDDDDDEANRKAPLTLCRKTSNLSIKRGIPECLKPVVEARLRSPEVNWIKNAFLEISPRDVLNLNRVDNVTDFVDVVVVRNTSQIPVMFKIKTTSPEKFRVRPTMGIILPESTEIIRVYLQNEYKNSCTREKFLLMALESENNNLETFGELWKNTHSERKVEQKLRCRLNNANLSDGYTNDNIDGGTNSVSQQGQIDRLRAQCEVMQRTQFILIIIMLMLFFILIVIVVNERWRFNALETTLNIFSNKLNTTECDKTSADKQLSSRAIKYEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT72</accession>
    <name>A0A0D8XT72_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716292">
        <property type="protein sequence ID" value="KJH47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT72"/>
    <dbReference type="STRING" id="29172.A0A0D8XT72"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010623">
        <property type="term" value="P:programmed cell death involved in cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="42736" checksum="062A85C7F8706EB0" modified="2015-05-27" version="1">MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTD5</accession>
    <name>A0A0D8XTD5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTD5"/>
    <dbReference type="STRING" id="29172.A0A0D8XTD5"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF4">
        <property type="entry name" value="BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="31604" checksum="8ED68F4F77F51E2E" modified="2015-05-27" version="1">MSAEERFRYVDVNFSYASYTTTYYGIIGVLLVYYSINWICDMTRLDNLIGFVHPKYDKVEKVFRKNFHDGWEREGAAIAVYHKGELVVDLQGGYADKSSGRKWTPETRTVVFSATKAVGALCVAICVDRGYVSYEDKMSKFWPEFAQHGKENITINWLMSHRAGLAALDEPISRDDANNFKKMAYIIAKQKPNWEPGTKSGYHAITFGWIVDQIIRRVDPLHRSVGQFFREEVAIKYGIDFHIGLPCSEEHTVSRLSMPSTAHLLKEIIHDPRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTF2</accession>
    <name>A0A0D8XTF2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716323">
        <property type="protein sequence ID" value="KJH47044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTF2"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000908">
        <property type="entry name" value="CBN-DDR-2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26943" checksum="B13AC75C47920142" modified="2015-05-27" version="1">MNSSTTMEISTHLFHLKYAWNLWKLKPVSPSTYQMAKDNIENALLEKCPIIAISSDYADPDFSYRDENSSLEPLLHSFHDHIREVNNYADSNMKIRSLSLSSSTKQRKRRTRYVNPLASVVKYSDYGEVYCSTLPEINRKQLDFIEKIGQGEFGELHRCLLESRQVAVKRLRSTSYEDEVAFLREIRVLGNLKHPNVVEVIGVSTIDKPMICIMEYMANGDLKSFMNKLEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTL4</accession>
    <name>A0A0D8XTL4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716393">
        <property type="protein sequence ID" value="KJH45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTL4"/>
    <dbReference type="STRING" id="29172.A0A0D8XTL4"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316:SF40">
        <property type="entry name" value="LD27118P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10316">
        <property type="entry name" value="MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="102"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="332" mass="37078" checksum="B5DFCD438FDE8E69" modified="2015-05-27" version="1">MSTAAPGPSVFEVYTYVDTNKSIDELFQAGRVSDGKLYERKPNRKFPMAYYAPKPRPRGSSAGHSPQGSSDDGMSNTGRNTLSPSGSQQVSTPFHKKQASAPELDTHHIELYNRPVPVPQVITHHHSKSVSAIPPMPDPAFTVPQHNRSVSHEANYNAFGTQPSFHEPVTSSLYDPRGKSHSLDPIVVGIHDPSSQIGGKINTLGPLPPNWEMKLDELGNRYFVDHNTQTTTWYDPRIRFQLINLSASSRITKRTLSDVRKTRTTASFELILVVLHEKCPTHSLGQSTRFRIVFILAPFKYLRTYLSSLTRIIDVGTVQSSMIYLIQVEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTU5</accession>
    <name>A0A0D8XTU5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha amylase, all-beta domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716282">
        <property type="protein sequence ID" value="KJH48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XTU5"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1,4-alpha-glucan branching enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
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    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Glycoside hydrolase family 13 N-terminal" evidence="4">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase/branching enzyme C-terminal all beta" evidence="3">
        <location>
            <begin position="510"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="604" mass="69786" checksum="3B850E7627100005" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU62</accession>
    <name>A0A0D8XU62_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAP/25A associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XU62"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="PAP-associated" evidence="5">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="226" mass="25941" checksum="5CD2CF69B2819902" modified="2015-05-27" version="1" fragment="single">DWRVRPLVSVVKEWAKRKGINDANRSSFTSYSLVLMVIHYLQCGTEPGVLPSLQQMFPRRFANKCDVRTLNVTLPLDTPAVSEWHYADKSTLGELLIGFLDYYANKFESYSTHSFFSYDRDAISVRLGKRIDRAVIARQRPNGGYQQSGTHWRSQWRCICIEEPFTYSNTAHSIYDEMVFDAIKTAFREAHQELDSTRDLQRLLNCKPISVNAPMGGYVAVALCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUH5</accession>
    <name>A0A0D8XUH5_DICVI</name>
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        <submittedName>
            <fullName evidence="8">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716308">
        <property type="protein sequence ID" value="KJH47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUH5"/>
    <dbReference type="STRING" id="29172.A0A0D8XUH5"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AcetylCholine Receptor"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Neur_channel"/>
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        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
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        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
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    </feature>
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        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="65"/>
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    </feature>
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            <begin position="73"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="252" mass="28508" checksum="44E1094119F614F0" modified="2015-05-27" version="1">MKFGSWTYSGFFTDLRNASVSVGTYQPNGEWELLGLTSKRSIFYYECCPEPYYDITFIISIRRRTLYYGFNLVLPIMLISALALLGFTLPADSGEKLNLCVTIFMSLCVFMLMVAEAMPQTSDSLPLIEVYFSCIMFEVGASVVCTVFALNFHHRTPESYHPMAPLVNKKDFTRMVTYAIIHGSTTANGTRQPTSNMKHKGYFADIDEKSFNNGDSFANHKTKAVHLDFCLESFRGKRSEIIAIGHHTLHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUL2</accession>
    <name>A0A0D8XUL2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716272">
        <property type="protein sequence ID" value="KJH48293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUL2"/>
    <dbReference type="STRING" id="29172.A0A0D8XUL2"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12383" checksum="E6196338887D019C" modified="2015-05-27" version="1">MSTWINATTSCASIYTLVAVTADRYLAICHTLKYTLWEAGYTLYVIMGIWIVSGSLATPSLYGYDESLNSTNTLVKSLCQRRFPDNTISVIKIYKSTLQSVSGLADLLRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUQ2</accession>
    <name>A0A0D8XUQ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716302">
        <property type="protein sequence ID" value="KJH47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUQ2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="196" mass="22482" checksum="4C0D221430439CCB" modified="2015-05-27" version="1">MSMMIFAARIHCGCGVMITSSYGSITLRLFAQDAQRLIRFRQMTKGTQAFGKKHVAKFAYNLLRVMILSLYIKILTTGKHLIVLKSKERFIWWPLNVPADFSLSDIVFASCCDISSHNIMQLVRSKAINELGTVWSATATYIWHDWKSDVSHHRYALHFIKYHPGNTILSPAVLKTIITQFDAYQGKQSAFLIMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUR2</accession>
    <name>A0A0D8XUR2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716301">
        <property type="protein sequence ID" value="KJH47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XUR2"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="2">
        <location>
            <begin position="536"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="646" mass="74475" checksum="EC6146346CF73259" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV08</accession>
    <name>A0A0D8XV08_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="3">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(D-psicosyl)-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61392"/>
            <dbReference type="Rhea" id="RHEA-COMP:15796"/>
            <dbReference type="Rhea" id="RHEA-COMP:15797"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:144621"/>
            <dbReference type="ChEBI" id="CHEBI:144622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:61393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="3"/>
    <dbReference type="EMBL" id="KN716365">
        <property type="protein sequence ID" value="KJH46191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV08"/>
    <dbReference type="STRING" id="29172.A0A0D8XV08"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000003">
        <property type="entry name" value="fructosamine-3-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000264">
        <property type="entry name" value="Protein-ribulosamine 3-kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PXA" evidence="12">
        <location>
            <begin position="11"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="223"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="408"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116722" checksum="5A94C00DE4CDF118" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVF3</accession>
    <name>A0A0D8XVF3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716294">
        <property type="protein sequence ID" value="KJH47744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVF3"/>
    <dbReference type="STRING" id="29172.A0A0D8XVF3"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="346" mass="38370" checksum="5EBED5A932402C6E" modified="2015-05-27" version="1">MEGAAYSLSPSACSFLLLSSAKRAFRKTDAVQSVNGAGKTSTFRVLSGQQVAERGSVFYGRTLLNPRSDAFSRIGYCPQFDALYDELTAREHLELLGRIHGYTSDSLDKVVEHLLETFDLLHYSNTKTAFFSGGTKRKLLMAQALIGDPHLLLLDEPTTGMDPNSRLYLWEAVNSFVRRGNAVVLTTHSIPESEALCGKLAIMEKSLVKEKFTEAFPKAVLVEDHANTLHFELPPPCILSELFEFTPLNVQEYVLSFSISQNTLEQAFMSFVREQADPGKVSRSVYSISTGDVCAVASTATEWSATEMSCRKSFTSTASSSSCNSRSRYWKIMKPNTEERDQKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVT5</accession>
    <name>A0A0D8XVT5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XVT5"/>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1582"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1806" mass="207036" checksum="085C3E166B05ED51" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWC2</accession>
    <name>A0A0D8XWC2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04908</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716250">
        <property type="protein sequence ID" value="KJH48938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWC2"/>
    <dbReference type="STRING" id="29172.A0A0D8XWC2"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="11">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH48938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="39807" checksum="1E180ED4FAF594A8" modified="2015-05-27" version="1">MDSRMMFFPENMLMSRILCHITPRQFIARRLIANSSIHRAEMKTPIQQWGWAYLQRQKALGRPISPHLTVYQPQLTWMVSGLHRVTGCVMAGVLLFGGVGFATLPFNFTEFVEYIRSWHIPAFVIAFPIIFHTLNGIRFIGFDLAKGLENTKAGMNNYVENTPDFEEPRLAVEGFVVCRLLYIVPPRKVAHIFERRHRIELHDFADELLENENLTFSRYCEIVDEFGRTADEMENGMSYGRLAGLISFGGLVAARLYACNLRREVQQIATYTSKFIDKRIRLTWVEDERSWKNFMLIGGDIVRRDAVQREAAERRRSSRRWSLIGIGAAALFGVGAIIGTRVLLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP3</accession>
    <name>A0A0D8XWP3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_07182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KN716336">
        <property type="protein sequence ID" value="KJH46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWP3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWP3"/>
    <dbReference type="MEROPS" id="C54.009"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="38"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="403" mass="45972" checksum="82F3800F6EDD5ACF" modified="2015-05-27" version="1">MHFSDGNYSSEGAQIIVLLGQFYYPEGDDNVNGTSFLDFCRDYYSRIWMTYRTGMPAFLGSVVKEQIFVQNVALGVQITSDCGWGCMIRTTQMALAQAIVVNQMTREWRFKKPSSMNEFRQQARSDPYASTQVEILRLFEDCHSAPLGIHKILEISKANNSVTNPIGRWYAPSEVLSLVRKALNLSVSPLTSDLSMLLALDGQVFIGDIERECLSWSKRLLLFVPLRLGTVCVNSLYNYHVRQLLSLKTCLGILGGKPHHSLYFIGCFGDDMIYLDPHVAQEYVPISTWDEDLAVNKDKNGKVRKHPLTTFHCRLFSKIAMKEMDPSCVVGFIFKSREELDESFRILNLNHVVDVDTGPEKIARRCKDPLFSVHYEEVTNNYSHYSVTDEERQNALEHGFEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWY0</accession>
    <name>A0A0D8XWY0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_05626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    <comment type="pathway">
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    </comment>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="512" mass="57619" checksum="8873EAE357D425D7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXX5</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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                <person name="Hallsworth Pepin K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716261">
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        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN QUI-1"/>
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    </dbReference>
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        <location>
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            <end position="621"/>
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        <location>
            <begin position="1327"/>
            <end position="1350"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="1371" mass="153253" checksum="901E971FF99192CD" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716258">
        <property type="protein sequence ID" value="KJH48724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYA4"/>
    <dbReference type="STRING" id="29172.A0A0D8XYA4"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF85">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYB9</accession>
    <name>A0A0D8XYB9_DICVI</name>
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        <recommendedName>
            <fullName evidence="8">M-phase inducer phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04209</name>
    </gene>
    <organism evidence="11 12">
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        <lineage>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
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        <reaction evidence="7 8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
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        <text evidence="1 8">Belongs to the MPI phosphatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="306"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="507" mass="56997" checksum="C1B8D37DEB5A123D" modified="2015-05-27" version="1">MSLGLDKTHTRLADENLGVTNHRSAEPGSFTGNQAEDGDSRDSGIVPDYLCPLKADTPLKVTVRDVLTDKTNINSYPEDNIQSNVPKTSIEESPITSRRRVHRVPSYSVLHCDDDKGSILSLPNLETSGSISMRAASSTSVSSFSYSESDIIWTPPKVKVACSRSTSEERTGPTTNFRKRYTENVVTEAGVAKKRSCAIRGDFIQASSEINLVQDGIFESNDKSPNTNAREFGLSGFSVGSRCFTRTQSTGQLEKGEVQQKSPNFNHEVEYSLPAVEHPQSESLAFRSISAATLASEIRRLGPEDFDRRYVLIDCRYPYEYEGGHIKCAVNIHDQNDLEKIFFPEDPDHPIHSRIPIFYCEYSQKRGPGMALALRSIDRMHNELNYPKVDYAEMYLLDHGYRKFWSDGCYKSECVPCGYVPMTDAAHVSSLIKYKWHKSKSTSQLVVREKERQPLRKATFYRYRSLMQVCTEVETKTDVAISPTAKTPDLSPRRLEYLDSPDSSKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYZ0</accession>
    <name>A0A0D8XYZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
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            <dbReference type="EMBL" id="KJH49077.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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            <end position="417"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="460" mass="53316" checksum="750795CD486C612B" modified="2015-05-27" version="1">MPNFLVVIMNRYVNHDSNRTNKNSEEAIKTELDDTKEKLRAMREHSSCLDKELNVVRTSLTEAEASLASHQVDLGDHKERIDRLEEELFAARSELDNARLGLQETTAVKKELDTLKKSNSILIFFINVYNKMLEHERCSGRAKWEEVCNKVLEHESNSPQSRKNSLEVINKVNLIVFVSHLLIDIFVVLNLVKLLVIEVQHLEYMAAFEEKITYLEKTLQEARNKNEQDKAEKRKLKLALKQLKDKIREKDRLIEDDSLEQRNVAIDEAALVSASPSASKRHDLDVDVEKLKNTIKTLELENRLSRELNTEYNHTMLEMQKEVIALKSQITSLREESKHFEMELKLHEVLEEELERELSQARLKNEDISNAMNTYEEILENLSEQVNSGASENDMRVKELTIEVIDLREQNRLLTEKLMNSTDCIVANECTSATDRQLSQPIEGWHINEDSFPISFSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ60</accession>
    <name>A0A0D8XZ60_DICVI</name>
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        <submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
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        <text evidence="1">Belongs to the TolB family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
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            <end position="872"/>
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            <dbReference type="ARBA" id="ARBA00009820"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="872" mass="98687" checksum="C97437F85B33ED4A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16117" checksum="15418D9EB96C64AC" modified="2015-05-27" version="1">MMLFLFVLRQCIPTQKKLISFLCTSTLNSGNSKNDSDAPVELKRNPYKKPDRKCLLCRTGIQLDYKNARLLQQFVSTFSGRLYDRHITGLCEHQQKKLIETIAISRRAGFMPIFVKDPKYVKDPKLFDPLKPIRPHSFA</sequence>
</entry>
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            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        <name evidence="7" type="ORF">DICVIV_04581</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
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    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZT1"/>
    <dbReference type="STRING" id="29172.A0A0D8XZT1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="392" mass="45133" checksum="C6189E30EBB43238" modified="2015-05-27" version="1">MADNEDLNKSFHPGKVIAGRWKVWEQIGVGGMGAVYKVEDKLRKNFFAAMKIEDNRTDIGLLKLEVHVLKQLQKMKYAVKLYDSGRRKNYRYAAPPPPSPLLPHIQSRVRELKSPRFGSSDEVAFDLFGLCGSFMVMSLFDKDLMTLKREYGGRPFSESTTLRLAISTLYAIKQLHEIGYIHRDIKSGNCMIGKYGRDRRMVYLIDYGMVRSFVVKDKNGKMAIRKPRDGEQLFRGTPRYCSLGTHYGKEQGRVDDLWCWLYMIIELHIGLPWSHLGDEKQILAIKENCPPNVLLKSCPKEFFKIHDYLKTLGYSDRPDYYGLYSECIAGLKRVKGSFLDPYEWEGPPEEFATALSISESCKTRKPLSRVKLANKTYPSMSVSFFKKNILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y057</accession>
    <name>A0A0D8Y057_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_04351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y057"/>
    <dbReference type="STRING" id="29172.A0A0D8Y057"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="55"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="465" mass="52300" checksum="C4B27D72099C38E8" modified="2015-05-27" version="1">MAPNGKMREIISLHVGQAGVQIGNACWELYCLEHGIQPDGTMPSDETVGQEDSSYNTFFSETQSGKHVPRAVFVDLEPTVVDEVRNGIYAKLFHPEQLITGKEDAANNYARGHYTIGKELIDVCMDRIRRLTERCQSLQGFLIFHSFGGGTGSGFAALMMERLSVDFGKKAKLEFSIYPAPQISTSMVEPYNSLLTTHTTLEHSDCSFMLDNEAIYDICRSNLNIRSPTYTNLNRLIAQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAFHEQLTVSEITNACFEANSQMVKCDPRNGKYMACCLLFRGDIVPKDINSAIAVIKTKRAIQFVDWCPTGFKVGINYQPPTVVPNGDLAKLQRAVCMLSNTTAIQEYMTNFYSENLQEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDIAALEKDYEEVGIDSYDPNDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y086</accession>
    <name>A0A0D8Y086_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Choi Y.J."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="170"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="499" mass="54946" checksum="C83398AA21393283" modified="2015-05-27" version="1">MISTNLGPIFGPLPTFNPLFVLSPSFQSETVFPVQSPKERICMVTVAIGPGRLFSGIGNTFAQAKANAAAQCLGFLGPHIQALDAKLRMDEQKRKCAQQKPPLLSQPNQLLMNVVDNVVDKLGASCERDPIPKHKQKSVISQVHECALQMKLNVEFEDMKMDPTYGHQINPISRLIQVLQARCENEPQFELVSEQGQSRYKEFTVQVSCGSRICCGSGPNKRLAKRAAAEAMLAEIGYVKPLPPPGKSLLKKKMDSQLNIELFDPNNLVSSSNEVLLHPDAKTYQQTSQNKDENLLQEGILSLNMNDYNTQESRCDAISISSTKSEIQESPGNIPQSPGRRRVTFSNQVKACPPPDDSNYPEPEVAPLKADVLIGSRVKRIRRSKEAKRALSDQQKFEIREIARASMQALQGSSMISCAEGANDSETCQSLSAKRHLEIMSETFKFSVQYTNFPKVCHGRGSTMETAVDNAAFNAISSLCTYDQPSIAQERTGAVAPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5C9</accession>
    <name>A0A0D8Y5C9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5C9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5C9"/>
    <dbReference type="OrthoDB" id="9974725at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24630" checksum="670B30EAAFA20430" modified="2015-05-27" version="1">MALLSLLLNNKNGGFHILPTIILYSFSFVSDRNSSHQVDWGDFYLVVRKIKDVYGADSMQTKFAKKTLAALWEDLCTLADLDEDQLISIDEWIKLLNDENLTKNENWLHKYEQFMFQLFDVSCNYIFDKLEVICNLNVLGDGVIDIDEYVDGMLVYGLDRDASRKAFQKFSVDDDGVYVPVITPTIWSTYFHELFHSIDRNALGNHLFGIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5T7</accession>
    <name>A0A0D8Y5T7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">molybdopterin molybdotransferase</fullName>
            <ecNumber evidence="3">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_02299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5T7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5T7"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051920">
        <property type="entry name" value="MPT_Adenylyltrnsfr/MoaC-Rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764:SF1">
        <property type="entry name" value="MOLYBDOPTERIN MOLYBDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="5">
        <location>
            <begin position="178"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="279" mass="31407" checksum="CE31755BE5E22474" modified="2015-05-27" version="1">MMTSNKFTNMLGEFFVSQKTPEFKPCSASMQELDKVIKKEKENYIQKSHVSHPRYMSADNIYHDVSFNSEEAVIVRDMKNKRKERPSSLVEKFKQRLSPSRNSERIVSESDCVMLETKADSNSSAFVKNLVMFAKEIVYFADKRIQKQKLLSLVDNSSLVDHHLKYAFLDCNRIANPTIYEPVIVPDERAMIESVLIEKSKVSDVIITTGGTGCGKRDVTPEATINVVDRRCTGLEVALHSHSLRITPMAALSRAVAGLRGSTLIVNFPGSVKAVKVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Y0</accession>
    <name>A0A0D8Y5Y0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_03854</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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    <accession>A0A0D8Y628</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
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        </source>
    </evidence>
    <sequence length="172" mass="19404" checksum="4DEB77F23D854D2C" modified="2015-05-27" version="1">MIDNKCQLDKRNLLDSLLSAVVRGGYHGTESTLDWIMPESCQINVVSPNNHVGPSNTHRSIFVFDESNELSNVETYNIKDLPTSSYIKVSSHRSFLEVENTETASNESVFRTETASENILGENAVEAVLLIAGETRTLRYQMFDRQGNPVPIPDLRSLYQILEVSLFFSLFK</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">HannoverDv2000</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ZIP"/>
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        <property type="entry name" value="ZIP9"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zip"/>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
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        <location>
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            <end position="55"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="30802" checksum="DD81ECA623DD3C17" modified="2015-05-27" version="1">MEGIGFLTVLSGSMFLGSYVAGSIPIMFSMSESRMRMVSIFGAGLLLGTALSVIIPEGVESLYNGLLGEFLSIKTRRKRGITNIPEFTNLDNVRKRRGSPTLGPPAVITKEIENTGHPPHRTRGVHREIGYPLVFGFIFMLLVDQISSAAGSKSDRSGRNRMGISATIGLVVHAAADGIALGSASTTNKSDIQLIVFVAIMLHKGPAAFGLVSFLLLEGIDVRNARKHLIVFACAAPFATILTFVVLGALGNDSVASSGSSTGILMLFSAGTFLFVATVHVLPELVRFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y688</accession>
    <name>A0A0D8Y688_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
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            <end position="445"/>
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            <dbReference type="EMBL" id="KJH52230.1"/>
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    <sequence length="516" mass="60716" checksum="BF087ACBA7556F29" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6C1</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="32908" checksum="F03534FE5291F6B5" modified="2015-05-27" version="1">MFLFTFVLLFPLVLTQQKKTVTVGVAAVENVMQPFIGYSLSGGAIGIALDRMRLEGIATGFDFKTMKKLAYCEHSYGTSNIHVMDSFRFLVNFTECTADNAVGLAVDFMKKHSVDAVIAPPCPIPAEIMGHLSTFYKKTLLGWGFLTDSKFSNSDLFPYITKVVPDTLGMVNCVLQLFSTFNWDRVAVFYTSNEVQYCESIADDATIALNDNSLYYVDVVQKTMVPSNNDAYLTKQLLRAKQTVRIILMCMDTAKDTRKFMRIASELQMVSDEFVYVSFGALGLGFGKILLFRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7E9</accession>
    <name>A0A0D8Y7E9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_01097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH52753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="104" mass="12332" checksum="25D697FA04419BEC" modified="2015-05-27" version="1">MQLRFEAAPFPAATVCNLNAFKYSELIQYEEIREGFDYWERVINAKAMNKMLRKEKRVATPVEIRRRRKLEHGADGFFDIHQYSYYKTAVVDSLQTKERKPIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7Q3</accession>
    <name>A0A0D8Y7Q3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_01535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y7Q3"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF131">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH52207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="291" mass="32242" checksum="2B357856386927B8" modified="2015-05-27" version="1">MCFIFSGAGKTTLMNTLLHRNLSGLDVDGEILVNGQNIGNGVTSVSAYVQQEDLFVGTLTVREHLMIQAKMKLPSTFTKDMRIAKVEEVIKDMLLEGPQSSRIGVPGIVKGISGGEMKRLSFATEMLSNPQILFCDEPTTGLDSHMAEVVVKTLDSLAGEKGKTVICTIHQPSSEVFEIFDKVVFLAQGRVAFHGPPDEAVWFFAECGYILPDHMNPADHFIDTLAIWPDSEEECKIRANEICNKFAISKYASELNAQMKEAEKPRSLCSHRGARFPDLVSALFLRLKRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8L6</accession>
    <name>A0A0D8Y8L6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8L6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8L6"/>
    <dbReference type="OrthoDB" id="5807141at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336322" evidence="1">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="212" mass="24162" checksum="4DC18AE38D4C0634" modified="2015-05-27" version="1" fragment="single">LSVCCLNLYLYVSSSLLILQIRASRSQHVRSVHPDYVPPKKKAPIGGYVADGKYVCHVPHCSWRGISRSTRASHMRKVHGGFTNPGYSTRQVACCDCHATFGSHKAFVDHMISVHRVGGLVHRDFNDIGEYEEWFNSVQEVFSVTYVKRMGIKQGNDYQVLYLYCARSGGFRPKHVPGRDYFPEFTKRRLTRRPTKCGRNCAAFLRVDNSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8M8</accession>
    <name>A0A0D8Y8M8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8M8"/>
    <dbReference type="OrthoDB" id="5792559at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12567" checksum="E02F5055737958F1" modified="2015-05-27" version="1">MQALWPYHTYRPVTWDRYYVNEHHDKQATVSSGVAAGVTIGIFLLVFIFTFGCRIYSQYADRTPSQTPRSQESVLSESLAEDMWICGVPQGPPPPYEIAIRMSSSPPDASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y907</accession>
    <name>A0A0D8Y907_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_00511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y907"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002832">
        <property type="entry name" value="ABC Transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="12">HannoverDv2000</strain>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>A0A0D8YAX2</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
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        <subcellularLocation>
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            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dynein-related AAA-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="122"/>
            <end position="288"/>
        </location>
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        <location>
            <begin position="406"/>
            <end position="576"/>
        </location>
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            <begin position="1004"/>
            <end position="1152"/>
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            <begin position="1341"/>
            <end position="1469"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="2070" mass="233275" checksum="5C551B3F56719BE4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB34</accession>
    <name>A0A0D8YB34_DICVI</name>
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        <submittedName>
            <fullName evidence="8">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB34"/>
    <dbReference type="STRING" id="29172.A0A0D8YB34"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="895" mass="98300" checksum="3E382F665B8BBD68" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCQ3</accession>
    <name>A0A0D8YCQ3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCQ3"/>
    <dbReference type="STRING" id="29172.A0A0D8YCQ3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
    <sequence length="218" mass="25622" checksum="A5DC1ED6F49F971E" modified="2015-05-27" version="1" fragment="single">LPSGLHILPNLFGNLITGKLQDAVQQDNKTINVLSQVQHNDNQETSHTDQPNEEIEKWEELWTLESTVNTVRSQNPEESDDESSQWEKFWTLETTGAEEFSNPEKETQIQVDQQVLEHFNRTIENRHDGYYVRLPWKNLATPLPNNRAIALKRVVSVWQSLNNDKELLDMYNNIFEEQLYLNILEKIKEENSLNLRRTYYIPHQPVLTPNKTTTKLRL</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH39684.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="119" mass="13764" checksum="0F67809385D3EEDF" modified="2015-05-27" version="1" fragment="single">MHLKKNDFREKEIIEGLRKEKPLRDAHDILKTVNNDYVITKETVQQLRQRVMNESRQPSIPKANPTHDFVIPREPADSEKTPTSVRTRKCFMTASRDSTSPTLANHISLDFGRVSMFSL</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN719711">
        <property type="protein sequence ID" value="KJH39862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7V3"/>
    <dbReference type="STRING" id="29172.A0A0D8X7V3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF414">
        <property type="entry name" value="CYTOCHROME P450 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181392" description="Cytochrome P450" evidence="5">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH39862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8720" checksum="7DE2390064957E44" modified="2015-05-27" version="1">MKMLLFDLLFAGVETTATTLKWGFLLVAINSQVQRRVQEELDRECLGDVVTLADRPRLPYTQATINVSDLISYRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X847</accession>
    <name>A0A0D8X847_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SRP54-type protein, GTPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN718910">
        <property type="protein sequence ID" value="KJH39962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X847"/>
    <dbReference type="STRING" id="29172.A0A0D8X847"/>
    <dbReference type="OrthoDB" id="6688196at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSY HOMOLOG, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9081" checksum="8B387F2B14DA0D3C" modified="2015-05-27" version="1">MACGVNGNGRITTIGKLAYKYKGAGKSVMLVACDTFRAAASEQLNIWAGRPGCSIVTGEYGSDSASAYRAVNQPMKDNIDVFLIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8A0</accession>
    <name>A0A0D8X8A0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718534">
        <property type="protein sequence ID" value="KJH40012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8A0"/>
    <dbReference type="OrthoDB" id="10329168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010466">
        <property type="entry name" value="DUF1058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06347">
        <property type="entry name" value="SH3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6957" checksum="66EFFE1B7C4FE977" modified="2015-05-27" version="1" fragment="single">MDIHLQKSAPKSDSEEFENWKKVCDIKGDCGWIKSNLLSNRRYAMIKEDTYGYPKQNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9A2</accession>
    <name>A0A0D8X9A2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_13884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN717619">
        <property type="protein sequence ID" value="KJH40184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9A2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans_2"/>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="34437" checksum="79CE44FADDDD2727" modified="2015-05-27" version="1">MITSDLYWQAKYYYDLYNCRYFAPFILLFLYSILGAWIFYVVENENEKEMKLFPWIKQIDLKLTCMMFVEGKEVTNSRRESLDLNRLRTHAFQRIVGLFQAKRRSERMSKSRDLLIWYEVELQKVKLPEALEWDMWGALFYVGTIFTTIGYGNIFPRTVTGRAISVVYAIVEHSIARVWLSHREKIKKAHQQTRNRFRSKERNRASIIDLEEGKFDPRTKSDFLEDQLIDESSKKQRVTFQAFTDLIHRIYYSVVVPRFQCFGVEHLPLLMSRYYNSLNMDDTQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9C5</accession>
    <name>A0A0D8X9C5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_13845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="KN717534">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9C5"/>
    <dbReference type="STRING" id="29172.A0A0D8X9C5"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
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        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="178"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="198" mass="21181" checksum="1185BD3C07759AA6" modified="2015-05-27" version="1">MEKVFTRYAAINKMVSGAYKSAFGETDEIAQVMERIKAFAAKEGRQPRIMIAKMGQDGHDRGAKVVATGFADLGFDVDVGPLFQTPAEAAQQAVDADVHVIGASSLAAGHLTLVPQLIDELAKLGREDIIVIAGGVIPPQDYDALYKAGVDLIFGPGTRLPACANQIYSRCARQVGTNPRKAKCQVIIILDSSLTTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9J9</accession>
    <name>A0A0D8X9J9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717394">
        <property type="protein sequence ID" value="KJH40304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9J9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11095" checksum="5D52B542ACA3F221" modified="2015-05-27" version="1">MLVLCRSSNAVEKEEHCGKSMMKFVLKLVLAVLLFVLATEARSVLSKNSASYGEENQLQLHLSAPRSSEYQLQLQLANENQLQLAREQQLQLAKEHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA43</accession>
    <name>A0A0D8XA43_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717159">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5875632at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="260" mass="30525" checksum="82CC08CE085BD065" modified="2015-05-27" version="1">MIQDRELIWRYTVSDIERNTIEQLKGQHTKFLKNHAIEVLSNARITADSERCMAGRICKIVENKEILVISTEDDISVVIPSLPDEIGNEITYNDKNSSTTFKLQDIIYIGEQTQCYNYTVTIARGEKTTKKKLKAFLYVWDPLRLPISFEELLNVLALSTEERMACVSNRRKEIFFLLHMIFTYVTIIKQPISIVETFQFHTDNFNGAPMDRCEMLCVMAFVLEWAHQTNSIPMELLKKHYEWCYTYARMSNFYMNHSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAZ0</accession>
    <name>A0A0D8XAZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716770">
        <property type="protein sequence ID" value="KJH41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAZ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XAZ0"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="15264" checksum="0D7F1FA1F78D082A" modified="2015-05-27" version="1">MILTFSEIIYDPFLSLFPILADQPDIMDQLRNLWNAKLNTMKNKSESEQAASFYRIFMNTAYCVHNTAIMPPYRIWDVEALALRQQLLKKCEDMLREYRTSTRFLLTEPCLPLNIYDYSFDLLGRHALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB08</accession>
    <name>A0A0D8XB08_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DB module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716760">
        <property type="protein sequence ID" value="KJH41790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB08"/>
    <dbReference type="OrthoDB" id="5843172at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002602">
        <property type="entry name" value="DB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705:SF13">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION DB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46705">
        <property type="entry name" value="PROTEIN CBG09805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01682">
        <property type="entry name" value="DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335747" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function DB" evidence="2">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16159" checksum="3E3470EBA7A9A01B" modified="2015-05-27" version="1">MRATLLVVLLLAVAYIISAKRDGNQKFKACCARQKSADKECKRRFCSFDSINQYNMLLVLNKCSPRGDTVKLMWDCASSQHDHTACCRKKNVLPMCMQYCDSSTPVPADYLNHLVCLQNFNVIKDCFQNHLEKHPNIFGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB50</accession>
    <name>A0A0D8XB50_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proton-coupled zinc antiporter SLC30A5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 30 member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc transporter 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DICVIV_13159</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716986">
        <property type="protein sequence ID" value="KJH40879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB50"/>
    <dbReference type="STRING" id="29172.A0A0D8XB50"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJH40879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="220" mass="24434" checksum="DCA6F7592A58B0B8" modified="2015-05-27" version="1">MYSFHGDGNHGHGHSHSGGSHGHSHSGNANMQGVFLHVLADTLGSVFVIISTVLIQWFGWVWVDPLCSLILSVLILGSVYPLLTSSVNTLLQDIPNEEEFEHHLCEVLEIDGVKSYSKAHFWQLKSDLNVASVHIQATQDANSQIIRHKVAAQLRAAGAAQYSIQVEKDAFLQKIQQLCPSYRFDHHVTRGTTIIRERKSHVSHGHSHHDHSHGTHGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBK1</accession>
    <name>A0A0D8XBK1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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    <sequence length="394" mass="44860" checksum="7717D25953514350" modified="2015-05-27" version="1">MLLEDKMRVFADEIEAVENSDGARFCRASERVAAAIYRAETPQRELYSSGTVYRSETPNRYFPENSPFAQRSETPAFPVMRETPLPFHPLLYGQNGSSRQDLDQLNNMNYRFESDSLNTSPFSSDIQAFLVCKESAMLNFELIITRRGRLTRIRVGFPAGIAIPSGSVVRLLPEESAAISSTHLKRMGQTIIASFTLHQSTESSIILALFRNFGMQIHKPEVRRLRKLWYDWPGQLLELYEVKKEKKRHTTRYPLFLYSDQMACKTSPSEGAVVQLKRSHDVSDISLVSSESSGCSSERSSILCSPSNAEETPIMHRTESSISPEISKTQSQNNEMNECDISTTSPEISPLPYQLMKKSSGLSREHRKIWRRQASNKNSRREAFIDGLIQRRIK</sequence>
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            <authorList>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="subunit">
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    </comment>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:import into nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="24364" checksum="A45B347946E4F6F8" modified="2015-05-27" version="1">MLKSAFVLGASGAVGTQLVDALLSSKQFKEIRIVSRRELPLNNESLKQVIVDFDTIEQYADAFKGMDIGFCALGTTRAKSGKDGFYKVDHDYVVNTAKVAKDQGVKEFVLVTSAGSNENSWFLYPKTKGQTEKDVEAMHFDKLLILRPGILEGPRAEYRLGESIAKIFVKPLKLISNSIAISTTDVAKAMVVGGCSADLKGNVVWDNATMLEKKMLFDDLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD15</accession>
    <name>A0A0D8XD15_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_11490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716656">
        <property type="protein sequence ID" value="KJH42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD15"/>
    <dbReference type="STRING" id="29172.A0A0D8XD15"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13223">
        <property type="entry name" value="PH-GRAM_MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF70">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="13">
        <location>
            <begin position="643"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="841"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="10">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="237"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121980" checksum="873399819E019797" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD21</accession>
    <name>A0A0D8XD21_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mbt repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716657">
        <property type="protein sequence ID" value="KJH42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD21"/>
    <dbReference type="STRING" id="29172.A0A0D8XD21"/>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="MBT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="118" mass="13434" checksum="96EDAA15C8D37BC1" modified="2015-05-27" version="1">MRFELMDPLAQMFNELRVASVLEVLKVGILGYLRVGMDGPDVETECIPLHCTSPFMFPVGYAQKYNIHLGGPNDTENFDWDDYLQQSGAIPAPEYLFRPTPEDTYMDHFQVSVSVAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDA4</accession>
    <name>A0A0D8XDA4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717253">
        <property type="protein sequence ID" value="KJH40401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDA4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13424" checksum="881A447A3F46D91C" modified="2015-05-27" version="1">MTRNKTNKNHMSKRIFEEGLDQQQMLKQLRDSSIQGLNKKEYVLKADSAAQDQAAFRLCHADQIMNVPGVCVRKLLCCTSGMIWMREKHATYSGLIRLQMKSTEIHLGRTACDYTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDX2</accession>
    <name>A0A0D8XDX2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="KN716624">
        <property type="protein sequence ID" value="KJH42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDX2"/>
    <dbReference type="STRING" id="29172.A0A0D8XDX2"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF10">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ACL-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="31655" checksum="F8E081FE5527685C" modified="2015-05-27" version="1">MASEEIGNQWCWCWAATALLLVMLLLISSRMRFVVKVSFYLTCLLIAGTVGGIVSLPYGRTPDNHWRVFTIFQWLCAVLRLRFVLRNRHYIDSDKPFIIIANHQSALDVLGMTYCWPKNCVVMLKSSLKYLPGFNICAYLCNAIFINRFSKEEAHKALDSTLYAIKKYKRKVWVYPEGTRNPGKVMLPFRKGAFVLSIQAKIPIVCCVFSSHSFFYDAANQKFDSGECLVEFLPPIDPSNFDDVLELSDYCRNIMMAKFEELNEELGNTLYLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE07</accession>
    <name>A0A0D8XE07_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DENN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716726">
        <property type="protein sequence ID" value="KJH41997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE07"/>
    <dbReference type="STRING" id="29172.A0A0D8XE07"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="378" mass="42233" checksum="6A237C51633759DB" modified="2015-05-27" version="1">MTDIEENGAYPAVLVIISPIRNAVFYLDLARTILKYIGRSRLELTNFLSSIVQHSYPQNRGASLVVVEKCTTGWPVRIEIFNQGTILGRTGCSQVIERISPEITTCIIAALLGEQRILLADNTVCSVSKLVQVMEALIQPLCWPHVFIPAVPDNLLDLCHNPTPYLMGILRNNLAPIHDLIIANHTVEIEVDQVDFVFIDADNGLINPPPQTYMNNGSVAAWKQQSAVNFCQRLGMPKKASMALITGLRSALADGSGPAADLRIENIMLVWYASLFGHYRAISCHCEWGPEFKLRLVDSQPDKTIRPYLSYLCETVMFHEWIVKRCSKAPEPADPLPGSEEFLNRRIDKLYLAGVNCFSTKPLTKMINKVTNALRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEA7</accession>
    <name>A0A0D8XEA7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin converting factor, subunit 2</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">DICVIV_11014</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716604">
        <property type="protein sequence ID" value="KJH42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="214" mass="24412" checksum="EB479E1A47FC1A63" modified="2015-05-27" version="1">MFNGRVVTRLDYESYDEMAHKELRKLCSYIRGEYPSIERIVIMHRVGEVAVGEISVIVATAAPHRGDALHATERAINQLKAIVPIWKKELRKLCSYIRGEYPSIERIVIMHRVGEVAVGEISVIVATAAPHRGDALHATERAIDHLKATVPIWKKEMYEDGGCSWKENNECCVDARPDVSVGENFARSNRTGDENLRVFWLRRMIKQMNNRKSL</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
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    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
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            <end position="157"/>
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            <begin position="183"/>
            <end position="200"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="23362" checksum="F93AE1565F27CCA0" modified="2015-05-27" version="1">MVREETRVYVGNLPSDCREKDIEDVFAKYGKIRFVDIKGGRGPMFAFVEFEDARDAEDAVRSRDGYDLDGSRLRVEFTRGTGPRGPGLPATGSWQDLKDHMRDAGEVCYANVSRDGTGVVEFTRFDDMKEALRKLDDTKFRSHEGETGYIRVREDTSGGGADGRGRGRGQSGSRSRSPRHSSPKNSPRSQSRSRSASRSPSRSRSRSRD</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="31757" checksum="7598442B66162954" modified="2015-05-27" version="1">MNVPPYIITQLEKANDVIRKQSEELDRFRSSGLQMENLALRTQLMEIAEQYRNNRDIFFDQEAVISELNHELKSLARDKEILQERYIELERKYKKAKAANKEFEKLVDMVESCSSKATESLSLVDRSRKKHISLSENIDGIFDESLQVLERDEEINELNCKLRSAELLRKQADEDLSRTSTDLALERARCDELTLSLQESEGLLSQTRSDCLEYALENQRLLEEIRDVNQLIVSYRAKLDAQGADLIATKKSLRALQREKCVPVSNAIMGTNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
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            <end position="58"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="39" mass="4658" checksum="F44D2AE20BE48168" modified="2015-05-27" version="1">MPTIQLQQQQYIRQLVIITLIRLVLLEILARENRHLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="145" mass="17036" checksum="56E26DD8EF18327A" modified="2015-05-27" version="1">MGCTFRVQLNDICSIWYSTLILCLQSYLIYLGFERHKLYTEMKWPANGYPHTWLTVYMILYTICIPLSLLLFSFGFFKSGNIAGDNEKLANREDRVIELFLNRKGEKPDICSVHFIIMTIFDLWNVNGIRVKDIRGYTSFRKGLK</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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    </reference>
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        <source>
            <dbReference type="EMBL" id="KJH42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="173" mass="20435" checksum="3E6088E80666EBEF" modified="2015-05-27" version="1">MIYDGNDLWLFRISLYLIRTSQHQIAKAKSMEQLIQFFQEIPRSRTALYCHQLIKSASLEHVTQKAIDELRSMHAYLDFYVETGRLIQLNSEFQAIRKLSSAAFKQSYSQNWHTVRVLLYNRMRTSTSSGKIEDLALLQSLLVDKKDGKNNSLDDSKIEMNWEILDYRKIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGI6</accession>
    <name>A0A0D8XGI6_DICVI</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
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    </reference>
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    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="392"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="249"/>
            <end position="273"/>
        </location>
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            <begin position="141"/>
            <end position="162"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="454" mass="49716" checksum="D44C26DE205F35E1" modified="2015-05-27" version="1">MLLLSNALCEDCKPISGDFLPSTQSTVTWVTDEKKVFRAQTEDERSQILMKADLKNRRADIYRCMSEWPVSVDAVELNKASGKMLIVKPGDAVLAVRKDPCNMWLCYNGYYNALLPSTILTPWYGPNAIGEIELVPSTLSLPNKTSSMPNRPHSTPPKQQIPNLLDLDDDLLPSTGCKPVTCTIPPLAPIPIGAAASNSSNEPELSSIDWSASNSAQPQPSLRAPSLPNLTSQISPVFPVKFDDAVDNNMLSQLPPAPSRLYQNTPASGTSSDYSQDPFTVMWEQIKNLPLSNITQRNESPQPTIPNRPAIESVASLSTPIPTFEQSNVSSFSNESASYSFPHHYDVVADKNASTSVQSSLAHPVSYEEPPYELFTVIPAYDTPPVENGRLPSIGKVLAQFDFKPVGPNQLEILTGERLDLIQAHDDGGNPEWIWVQRVNGEHGFVPASYCKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH40</accession>
    <name>A0A0D8XH40_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716516">
        <property type="protein sequence ID" value="KJH43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH40"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="23910" checksum="69698A74E936374B" modified="2015-05-27" version="1">MPGIKIMSDERGEHIKALEVQNKLKVEELAETPGKLVAIRKDSSPFYSSMTKRIFSPCEDRECCAICRDLKVMHYKQHFETHPDRQKEEDSLKAMEEMGREATRNLSWLCHNVRRVASSKSIEDFAIFKALYGEPISETPVTVAPSTTQWNDEASVDVIKRTHRSESESANEVEKVDAEDPSKAKALYTSLRAISWSGKSFAKACRSNPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHB6</accession>
    <name>A0A0D8XHB6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme NO binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN716590">
        <property type="protein sequence ID" value="KJH43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHB6"/>
    <dbReference type="STRING" id="29172.A0A0D8XHB6"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000005">
        <property type="entry name" value="Soluble guanylate cyclase gcy-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF16">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19913" checksum="2D84156FC2587881" modified="2015-05-27" version="1">MTSTKERAGLEPGKESIVNHYYPDSETYALVDAVCVIAKMSREEVWETYGGFLIEYTMETGWDELIQSMSPNLKGFLDNLDSLHYFVDHVVYKANLRGPSFRCEENSDGTITLHYYTGRPGLYPIVKGLLKEAAKRIFKLDLHLTITGRTQRSVQMASGERIEEHVIFLVKVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHS3</accession>
    <name>A0A0D8XHS3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_10679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716572">
        <property type="protein sequence ID" value="KJH43309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHS3"/>
    <dbReference type="STRING" id="29172.A0A0D8XHS3"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12338">
        <property type="entry name" value="RRM1_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="121"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH43309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="323" mass="36119" checksum="1DB1B6241443AFDB" modified="2015-05-27" version="1">MGRDDTRIYVGNLPPDCREKDIEDVFTKYGKIRSVDIKGGRGPLYAFVEFEDSRDASDAVRSRDGYDLDGSRLRVEFTRGGGPRGPGGRSGRGGGYRGRGGYGGDYGSNRRGGQASRRSNYRVIVEGIPSTGSWQDLKNHFKDHMREAGEVCYANVSRDGTGVVEFTRFDDMKEALRKLDDTKLRTHEGETGYIRVREDSSNGGGGGGNRDRSKSRDRSRSRDRSRSRSRSPRRSSPKYSPRSHSRSRSTSRSPSRSRSRSPPFHKKKGKMRKDVVNGGLEERTYSTVGCESARTYSGKDIRLHGLLETSYVDCRGRKGETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI48</accession>
    <name>A0A0D8XI48_DICVI</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="8">HannoverDv2000</strain>
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                <person name="Hallsworth Pepin K."/>
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            <strain evidence="8">HannoverDv2000</strain>
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                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716537">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XIQ7"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="15608" checksum="31EFE745D8FC3D3B" modified="2015-05-27" version="1">MESISEELSLYIVKGDLLMECLLEADPPPVITWQHAGNVISQSARVSQTLSPLDGILYKANLTIKELARDQEGFREEFNTMGPYLRNRKIHGNIIDEPNVGDGGAYKCTARNQLGESNANINLNFAGLPFRFSILISRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIU6</accession>
    <name>A0A0D8XIU6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716462">
        <property type="protein sequence ID" value="KJH44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5046242at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF407">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="19492" checksum="D0D53AA368C28C24" modified="2015-05-27" version="1">MMKVFLEYTTPWWPHDVYAIAPLQSSSPLAESFPMFQPLHWNNKILVAWVSGKGPSLVSGLSDRELIEGLTSHLREALGDRTIPTPVKIFRHNWITDPLVGGSYSYLTPRATKFVPDIFKTMAEPVNINSRPIICFAGEHTHATMYQTTIGAYESGEREAYRILEYISHNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ70</accession>
    <name>A0A0D8XJ70_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716520">
        <property type="protein sequence ID" value="KJH43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJ70"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tetraspanin"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
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        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
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            <begin position="55"/>
            <end position="79"/>
        </location>
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        <location>
            <begin position="86"/>
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        </location>
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        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="278" mass="30866" checksum="E4ED120D96923A3B" modified="2015-05-27" version="1">MGGCVKTLRSLVFIFNLFFWIAGIIIIGLGVWLLWDPVASDFFALHSTHHGSFQIVGWLLLAAGAITTFVGCCGCCGAWKMNQGALVGFFVVLVIVFCFELAAAYMAYSKQETIQQYIESSMYDTIRNRYASDANYKSAFDTIQREFECCGVKSYADWLGASWDRKLSHTHNAELKVEHGIGAIGSRRENGYGRTPFSCCNDHGKEIYPTKCGVSFIHAPLETYAEFLYSKGCADAVYESVYRHLNLVIAVCVIVGAIQVMSSLTVIKAPNEIFTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJK5</accession>
    <name>A0A0D8XJK5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716449">
        <property type="protein sequence ID" value="KJH44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJK5"/>
    <dbReference type="OrthoDB" id="5873825at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="32417" checksum="A32BC461DA8E49C3" modified="2015-05-27" version="1">MSDCLNPFAALLQPSQLAAAFQQNNADISSLSNTNSSPPYSQAGTEQMQYSTPESCTDQRAETPSSDQMNGDFSVSNDYSPDNDTASDRDQSPDCVSTSSGEPHLLGLKTISADDAELQRQILRLQSFNDDVDKKPALNLLSSLHNNPLLAEKLASCMIPGITTSPSATTVSLAASLSQNQNNHDVTPTKRKRQRRNPVWPYFDVVDGTARCKQCLYSTKSVFSTNLKVHLRSHHRADYEKVIQAEDALNLNALLLSGNSSKLFTTDLTRKRMPPMTSSILMTINKSLNTTTPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJV2</accession>
    <name>A0A0D8XJV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716442">
        <property type="protein sequence ID" value="KJH44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJV2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12681" checksum="D04EAA8AF66EFD64" modified="2015-05-27" version="1">MKTQFIFESQSTSLVVIRSFHPHLTLRRHWWSSGRLIFIFLSEAIDGHSTPLVVTQLFHLHLSFISDWWSSGRFIFISFSYVIGGHSVQVNFMILSDVTSYEDDESRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJZ4</accession>
    <name>A0A0D8XJZ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_09033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KN716439">
        <property type="protein sequence ID" value="KJH44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJZ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XJZ4"/>
    <dbReference type="OrthoDB" id="9985088at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="761" mass="85888" checksum="B17FA9C4BCFD7AA1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL56</accession>
    <name>A0A0D8XL56_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716412">
        <property type="protein sequence ID" value="KJH45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL56"/>
    <dbReference type="STRING" id="29172.A0A0D8XL56"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901990">
        <property type="term" value="P:regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716490">
        <property type="protein sequence ID" value="KJH44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPE2"/>
    <dbReference type="STRING" id="29172.A0A0D8XPE2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="61" mass="6205" checksum="E8CBCE2010CCAF38" modified="2015-05-27" version="1">MFPNVPNKDIDSAAKYIKAGAATVGVAGSGAGIGNVFGAVVIVYARIPSLKQQLLTASEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPG7</accession>
    <name>A0A0D8XPG7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPG7"/>
    <dbReference type="STRING" id="29172.A0A0D8XPG7"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="10">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="240" mass="28737" checksum="0062C6217615032F" modified="2015-05-27" version="1">MSKRRFESSSDDKIPVVEKLYRQNQPSFHAAGGFMEDDDEYQQKREEIFEKKQKKADAKFADYEAPDNCIKCNLPMFDSWLWERYNHPVCDSCRDDSGEHRLIPRTEVKSAYLLKDCDLDLRKPPLRYWAKKNPHNPRYGDMKLYLKCQVIQRVLDVFGSWERFESEKVLRSSLKETRAEKNFEKKVKEMRQHIRGLGQVKIKEHATHEHVYGEETYDSTKDEYSKECIHCSYVLKYEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPP5</accession>
    <name>A0A0D8XPP5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="11">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="11"/>
    <dbReference type="EMBL" id="KN716388">
        <property type="protein sequence ID" value="KJH45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPP5"/>
    <dbReference type="STRING" id="29172.A0A0D8XPP5"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF29">
        <property type="entry name" value="ELONGATION OF LONG CHAIN FATTY ACIDS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="24642" checksum="E43D1763AD1E6EA3" modified="2015-05-27" version="1">MTSEMIFGDFNYEQAKAFCASIENFSAKLSIAYVAAIFSIKYYMRDRKARNLQLPLSVWNGILAVFSACGFFYTFSTFLKVVRDKGISYTYTNISEVYTDEKCGYWVLLWVLSKIPELVDTIFIVLRKRPLIFMHWYHHALTGYYAIINYHEGNAHMFWVVWMNYGIHAAMYRRKGWERVCNSDADIFRHDRLKKTARENNHLLVSLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPW7</accession>
    <name>A0A0D8XPW7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TCP-1/Cpn60 chaperonin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716387">
        <property type="protein sequence ID" value="KJH45782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPW7"/>
    <dbReference type="STRING" id="29172.A0A0D8XPW7"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="25261" checksum="7D1D7E12D728C4A9" modified="2015-05-27" version="1">MLSDFFDLSHPSNNETIDHFDAVSCKSKLRIKNKTYYLSRKPERQPIEGEKGNVATILIRGSSQSRIDDVERAVDDAINTYKALTKDGKLLPGAGAVEIELARQIENYGEKCSGLEQYAIKKFAYALETLPKCIAENSGMDATDILTKLNAAHEAGHQNAGIDIWKHDIMDASENNIFDLYCGKKSAIKLATDAATTILKVDQIIIAKQATGGPKPRGQKSQDEEDEGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR55</accession>
    <name>A0A0D8XR55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR55"/>
    <dbReference type="STRING" id="29172.A0A0D8XR55"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF171">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16366" checksum="21B9CF6550BABBB8" modified="2015-05-27" version="1">MPFSWVFPVELSGFVSPQSIRFTLTPFLSGSRITCNLLAKEEYFFHFRVDFHNQQDKASEDAVVRGSTKNLIWQKEERAISRFPFSKGITCDILFIAYGSTVAVDVDGVPFVTFKYRDGDDPKFIDRVTVNGDCVLHRFTHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRV2</accession>
    <name>A0A0D8XRV2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716316">
        <property type="protein sequence ID" value="KJH47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRV2"/>
    <dbReference type="STRING" id="29172.A0A0D8XRV2"/>
    <dbReference type="OrthoDB" id="5912168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336060" evidence="3">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="55"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="298" mass="33257" checksum="2E278233EF6A5268" modified="2015-05-27" version="1">MDVLEFIVIVFLLIIEQSFAENEATSSGRLSREESNELKKTCGRTHFSRTIEKRSVGGRKAEKNEFPWTVAVLGESICSGALISDRHVLTSAHCGIKRIHRVRCEEMALEDTYEKLEEELIVLSGMEEGCSVDTKEGCTLFKAIDMIVHPKHNPCNGDYDVALLEITPSMTPDKGSPICMPKEYEEVPTGENRMTAAGFGVNPEHPNERYLDALNLTMDGIEREHARIVTKSYGRSICKGDSGGPLSKLKRSGQNVLLGITMGYHDCVQDSEEHLSFFVDARLCVPWVWVCPKTKSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSB4</accession>
    <name>A0A0D8XSB4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716341">
        <property type="protein sequence ID" value="KJH46672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSB4"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354651" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="21"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="628" mass="71564" checksum="61DBA067CA6EEE08" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSE8</accession>
    <name>A0A0D8XSE8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716341">
        <property type="protein sequence ID" value="KJH46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSE8"/>
    <dbReference type="STRING" id="29172.A0A0D8XSE8"/>
    <dbReference type="OrthoDB" id="5862419at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="10199" checksum="302741DB47382604" modified="2015-05-27" version="1">MGDHGPRREGINATVLGHYELNNPFLVATVPKQYRNTEIHERMREKSNQLMTNFDLHATLMDIMKFGQRYISIFISFTLYASYTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUD3</accession>
    <name>A0A0D8XUD3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="KN716375">
        <property type="protein sequence ID" value="KJH45991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUD3"/>
    <dbReference type="STRING" id="29172.A0A0D8XUD3"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="20611" checksum="B18384ECCBFF104F" modified="2015-05-27" version="1">MGEFPKVELPSENAPTELVTVEEGKAKLRLTGPVFYNPVQEFNRDLTVLVLREFVRSRATSTNVQCALSEPKTKKVKYVAENEDNSIRVLDALSASGLRALRFAKEVNNVGFVLANDFSEKAVQSIRDNILLNDVGERVIPNFGDAVETMMSHRYTNKRFHAVDLDPYGSASVFLDSAVQCVADNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV55</accession>
    <name>A0A0D8XV55_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716266">
        <property type="protein sequence ID" value="KJH48503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV55"/>
    <dbReference type="STRING" id="29172.A0A0D8XV55"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="88" mass="10214" checksum="037231FEE28EFE8C" modified="2015-05-27" version="1">MLFADDEVVTHIISQTIYISSPFKSRNNRITPARPRELKRLKKNQRTVTRTYGGCLSPNAVKERILRSFLLEEQKIVSRVLKSRRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV88</accession>
    <name>A0A0D8XV88_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716361">
        <property type="protein sequence ID" value="KJH46271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV88"/>
    <dbReference type="OrthoDB" id="5782208at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="12787" checksum="F3986D7C1716F2FB" modified="2015-05-27" version="1">MNLYSPKKLEALEAEINSVIRQVAVWTKELGEVNANRLQIEVNQQNEIRFMQLSSEIKKSMACMQIASIDFELIQLRHNERWRRFLADHVPSEKLFTLLQSSEEIGNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW24</accession>
    <name>A0A0D8XW24_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716259">
        <property type="protein sequence ID" value="KJH48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW24"/>
    <dbReference type="STRING" id="29172.A0A0D8XW24"/>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="258" mass="28480" checksum="252C31D79913597E" modified="2015-05-27" version="1">MEEELRCSQCRKFFEDPILLLCGHSYCRKCALKAQQPSSSARPATPLAPLPHFPQIPSSSPMFLMTIDFNMIAALYNIPGASDTVSLCVSDTDHDSDKMSVLSEADSGVVCCRASRPSSIVGPPFPRLPTILTPSTSGIIIPCGVCQKPSYYSDEAAILNAPVNMAIQNVISRYFAQHPHLAPTDQHIVDDSNIEPVCQLCEENVRPATVYCEQCDILYCSSCQLALHPQRGPLAKHNLTDASQRYRQFQLFVFLKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWH1</accession>
    <name>A0A0D8XWH1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EZH1/2 MCSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWH1"/>
    <dbReference type="STRING" id="29172.A0A0D8XWH1"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EZH1/2 MCSS" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="417" mass="47627" checksum="16D6720E1546D8AF" modified="2015-05-27" version="1">MYGVESAWLINALITAFVSTKLKALTLVIPNFAKIVQKLPIRRYHTYDDSTPIRLDIPPDDLSEFITHFKMQRVRWYAHPHINICIQQIKCLITDCRNMNAQRCGVRFLPVLELRPRTAYWADEEHRLSHIPFVSEDHDDKQFCAELRKLYDEGIHGADRGCDKYINDYIMFHMLEILKLDWEDRPNSEKIMDHIFYAIFKLFPNKLSHRQLVTARGDLEERFAPGRTPSKSTQDLRASSDQNFHSVNVLCCERCYQYDCVLHAGPYDDDIKPFKRKQGERAPRPKPCSSHCHLIEPSIGVNGNLPNRCRSPRSPISPRSRSRTSNLASDNSLSGITNGQNSSGKVAPFMNPTLMNILVALLAGEQTSICLVTAQMNMICQDIGVEPRTCSEIYRLAAQLAEANPSLTSDQKKFCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX24</accession>
    <name>A0A0D8XX24_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MED4</name>
        <name evidence="18" type="ORF">DICVIV_04684</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MMACHC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX24"/>
    <dbReference type="STRING" id="29172.A0A0D8XX24"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033787">
        <property type="term" value="F:cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12959">
        <property type="entry name" value="MMACHC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032037">
        <property type="entry name" value="MMACHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457:SF2">
        <property type="entry name" value="CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31457">
        <property type="entry name" value="METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16690">
        <property type="entry name" value="MMACHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="13 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH49183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="554" mass="62567" checksum="A164D7AF7FC6C4B0" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXU3</accession>
    <name>A0A0D8XXU3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXU3"/>
    <dbReference type="STRING" id="29172.A0A0D8XXU3"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14866" checksum="35453462D1EC5F2A" modified="2015-05-27" version="1">MSFAINSTTLQICKFLMTSSCYSILCEFQVLQFIRNGKHTSIPEDKHLLKQLLVFINTTETFFSKKANQGQHGIRVCVEKKESSMRFKFQCEAEFFGLDVYRRMLRRRLWKMTGKPTYYACYSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXY0</accession>
    <name>A0A0D8XXY0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716317">
        <property type="protein sequence ID" value="KJH47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXY0"/>
    <dbReference type="STRING" id="29172.A0A0D8XXY0"/>
    <dbReference type="OrthoDB" id="5919603at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="14978" checksum="546A2BE16F64B77F" modified="2015-05-27" version="1">MMMMWFTNVARGRYSPRSSANADGDLTNAVRWRGRVCIERSTTMSTATATANESGGPSYGIGQSLCIALLTMGQCISKDQKEGKRLNRRIDEQIKKDQSMSLRIIKLLLLELYESKEGGRGKEREVKRVDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYA6</accession>
    <name>A0A0D8XYA6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05055</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716255">
        <property type="protein sequence ID" value="KJH48802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XYA6"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14128">
        <property type="entry name" value="STKc_CK1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="38767" checksum="B13EDF7C43CFB9E7" modified="2015-05-27" version="1">MASVISSKDFIVATKYKLIRKIGSGSFGDIYVSINVTNGEEVAIKLESNRARHPQLLYESKVYRILQGGVGIPHIRWYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRVHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRGTLPWQGLKAATKKQKYEKISEKKMSTSVEILCKGFPSEFPMYLNYTRGLRFDEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKVSQSQNTNMLQPGASGSQQPKTVVSLAPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYT2</accession>
    <name>A0A0D8XYT2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYT2"/>
    <dbReference type="STRING" id="29172.A0A0D8XYT2"/>
    <dbReference type="OrthoDB" id="427410at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22423">
        <property type="entry name" value="KH-I_MEX3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22424">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000012">
        <property type="entry name" value="Mex-3 RNA-binding family member D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047228">
        <property type="entry name" value="KH-I_MEX3_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047226">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047227">
        <property type="entry name" value="MEX3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285:SF7">
        <property type="entry name" value="LD09246P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285">
        <property type="entry name" value="RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="470" mass="51084" checksum="E0B61819BDD1EE4E" modified="2015-05-27" version="1">MAGLLQYSSTASRGSEEGFHSGSDDAAIDNLAYQLYSQFRFDENQFERHKCASDSGTSSGELEHMFVMKEESIGCQSQLPGAWFYEMGDDASASPTYDQEEMAAFRGILGSRNCSESVEVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPIRGEDPVFVVTGKAEDVLEAKREIECAAEHFTQIRASRRHSHGGAPAPGHVTLYVRVPLRVVGLVVGPKGATIKRIQQDTHTYIITPSREREPIFEVTGLPQNVEAARKEIEQHIYQRTGNMPMTDPEASITQYSNLQSNLSLATSASAAARSAYGSLAQPMIRRAPCSDNYTEYTRPLDRSIYNGLLRGYPQTTKQSYSVGGSPPAVSPSFFGSSSSSTTSNAFQPWSSNFYSGLGLSETSDLFSNRSSVLSGASLWSSGFGSMSCGQQIPSNQRDEGLGDSPPNNISSTTYNLMSSIWADIDAPREPETKGVAMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZC6</accession>
    <name>A0A0D8XZC6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZC6"/>
    <dbReference type="STRING" id="29172.A0A0D8XZC6"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="164"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="370" mass="41133" checksum="5E2067F812BF7721" modified="2015-05-27" version="1">MVSTSAPSTSFHRDEVISGSELNHLMTTDSLSICILDCRAEGSVIRSSNRIRLPNVLYRRLINCSLSLSTLSPRLNNADVKVVIVPEQGSDCPISNAIANALRKASINYRVVKEPIETVLSSFPLLRVDGERPNSQSADVGCLNLNALQIEPGVAQYTDKRQVFPVQILPHLFLGNYETASDAQLLDRMVFLCSNVLILFGSQSTILPFYLNLFYSWLWTGVHYIINVTSNLPNKFENDPAFHYQRISVDDNSSHNLSHYFPGWLCFSFFTGKFLGENISFPEAIAFIDAAASAGDACLVHCLAGISRSVTICLAYLMTKNKWSLEDAYDLVLRRNASIAPNFHFMGQLSEYERYLGIRGSSVDVVKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y097</accession>
    <name>A0A0D8Y097_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KN716210">
        <property type="protein sequence ID" value="KJH50278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y097"/>
    <dbReference type="STRING" id="29172.A0A0D8Y097"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="229" mass="25675" checksum="22191E8C3BD660E7" modified="2015-05-27" version="1">MSLKLSDIELLWANDDIVKIRLAEKGFNSDEILRNINHSDRVTHVYEGGFKIWECCFDLCRLINNEPSLVRGKRVLELGCGAGLPGILCALQGADQITLHDYNDYVVQCFTQENLELNGIQKSKYCLKSGPWSDYRAALKASKSIFSYDLIITSETIYNTDDYSSLHDAIVYALSLTGIVLVAAKCSYFGVGGTVPEFVDFVKNKGIFKISTKHYVPSDIPRVILEMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1X9</accession>
    <name>A0A0D8Y1X9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1X9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1X9"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336406" description="Membrane magnesium transporter" evidence="9">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13841" checksum="ED11EFCC8E63E3E9" modified="2015-05-27" version="1">MSKTFYNIITLSSLISLLHCAYSAAQHRSYLRLTEQPFVSLPADVLAQTLISLVALIYGASHVAGEFQHIKSDPNRDRSWDEAASCMSFITFEHRGKAMSPAHAVVRQRTEEVAQVYFRVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y298</accession>
    <name>A0A0D8Y298_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716210">
        <property type="protein sequence ID" value="KJH50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y298"/>
    <dbReference type="STRING" id="29172.A0A0D8Y298"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12943" checksum="827B1AA6C207192C" modified="2015-05-27" version="1">METGDEECSSSYVECGTHESVRLRSVQHSASINLDLDSEDIAEKVFRVLNVDKDPNRSHVTRKLSVNGCHLHIDIVSMDRTSLRKSMVNVLEMCDLAKATIDLVHARKWLNFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y328</accession>
    <name>A0A0D8Y328_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major sperm protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_02679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.</text>
    </comment>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y328"/>
    <dbReference type="STRING" id="29172.A0A0D8Y328"/>
    <dbReference type="OrthoDB" id="5915816at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21513:SF2">
        <property type="entry name" value="MAJOR SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26138" checksum="E76AD05992A8ED06" modified="2015-05-27" version="1">MTTSCKYRKVAGMASDGNEGSKITEKPNEEKQEGGEGKQAVTERGADDKQKTGDEKGKSSLSKAKENQENDKAAADQKKEEKIISDVARLQKHEYILVFNKAFPLNLNNYKIANKFRDAAEEPRNVIFKVPPEKKPIWSDIKLQNPTNENKTFKVKCTSAVIFRVQPPFGLVKANETTKIRVWFQNTNGIPSDGKKHYFAIYFMNSEEGKLPKEMWRKDSKPEGCFRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3U4</accession>
    <name>A0A0D8Y3U4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_02290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716181">
        <property type="protein sequence ID" value="KJH51553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3U4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3U4"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH51553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="22204" checksum="219DE9DBD614FA9E" modified="2015-05-27" version="1">MGNSSSLMLRDEEIEEISKETEFNRNQIVRLYSRFLSLDKKGQGFLSRDDFLNVPELAVNPLGDRIVDAFFTLAGENEQQLNFRQFVRILAHFQPINRSKKNALNGRKEKLKFAFQMYDLNKNGYITREEFKVILNSMVGANITAEQLDKIADRTIEEADGDNDGRISFEEFCRAMEKTDIEEKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4I4</accession>
    <name>A0A0D8Y4I4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit DAD1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716179">
        <property type="protein sequence ID" value="KJH51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4I4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4I4"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15706" checksum="FD2F81FD7502658B" modified="2015-05-27" version="1">MYELFRILKVTVCRWCFSRRVIGGLNMQAVQVIKKLFDDYRQTTAKRLMIIDAYMVYILLTGIAQFSYCLLVGTFPFNSFLAGFISTVTSFVLASCLRIQVNDENKSEFSHISPERAFADFIFAHVLLHLVVANFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4X7</accession>
    <name>A0A0D8Y4X7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4X7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4X7"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="42137" checksum="7D3663A4B5882FD0" modified="2015-05-27" version="1">MSTEDKPSTSKDTRMPENAAPVTGAVDAAARQGDQIEALAKEAEELRKKLDQERQKLNDIPIQQAAERLDPLPNLGIKQRRILKGHAGKVLCMDWSLDKRHIVSSSQDGKVIVWDGFTTNKEHALTMPTTWVMACAYSPSSQLIACGGLDNKCSVFPLSFEDDILQKKRSVATHTSYMSCCMFLRSDNLLLTGSGDSTCAIWDVESGQMIQNFHGHTGDVFAIDVPKCDTGNVFISAGADKHSLVWDIRTGQCVQSFEGHEADINSVRFHPNGDAFATGSDDASCRLFDLRADRQVCVYEKESILFPVNGLRPDNVTGYDFEGRILFAGYGDYRVGIWDSLKCVRHSVLYGHENRISCLRTSPDGTAICSASWDCTIRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Z7</accession>
    <name>A0A0D8Y4Z7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Z7"/>
    <dbReference type="OrthoDB" id="5808026at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="304" mass="34009" checksum="D11AC8DAB3D000D1" modified="2015-05-27" version="1" fragment="single">LRNVEYTSGRGNTLPYLYGYISETDWKNSPHFPYRVHFSKSKHPWPSEESEYIWASSYDVLPTTHDLLLISEEERIRVASTLLCSCGGGEYGIPCSLFRSYLCRNGMAKACCLNSGKPCSYHEECANGDDTYNRMESLAKAYIDGHGVRSKFSLLHPGSAVLPQDGNISEMPVLPNERCERKETEQEVYPTVSNILLARADQTLIPAMSKALLASPVVENKVSSSQCITIGSEPSTNNIVGIYTEKPPSLKRVIYLRRTMKSRIPEVKSISSCLSPQGNVSKQQIRKSTRNCKNKVFDDFVAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y556</accession>
    <name>A0A0D8Y556_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y556"/>
    <dbReference type="STRING" id="29172.A0A0D8Y556"/>
    <dbReference type="OrthoDB" id="117690at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50477" checksum="51236378E8D57035" modified="2015-05-27" version="1">MNVKLITFNVFPQFKSTTGMIRHLRSCHVQEYQQVQEARQSTLILKMDLDIIDREFFSLACTVCRIDDRTHWVTAYRMQYSRPTSSSRPILRCEAFNLNQSTVKAGQALFSFESYQNLNEQMMFVVQEKARAQLLREMNTQVASTMVAHITKKTSPEPQKSPSASSSSSDTNSSGSSLFGPALPPLPPLSIAPAGLPAPKPVKIFTQPMVIKRDATEVEEEMQEPTDLSQKTSAFSVLSQKKCNEEIENDFDQKSRLTSTPRHFQLRNVDERKINAQFFFSSLDPTTLVINRVLLSIVFMYDVSTFHVHSTATEPVPSYLTPISLPHFNYTFLRYRKPSHIIKTHNEPHKEMRMPLYSKKFAYLLAKFSNNTMQKIAMMMLIDQIPSKIVDGHGFRSLMSFLLPEYPMPSAELFESTICPEVITQIQPHLSALFVTNNRELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y619</accession>
    <name>A0A0D8Y619_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein UNC80 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y619"/>
    <dbReference type="STRING" id="29172.A0A0D8Y619"/>
    <dbReference type="OrthoDB" id="5870652at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6801" checksum="C95BF95EB5F038D0" modified="2015-05-27" version="1">MIIEMLDDPEVDKNGISVSDVSRKVIWTCIVEDPSLFFRHFLEKLTNRERQVRDHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y630</accession>
    <name>A0A0D8Y630_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y630"/>
    <dbReference type="STRING" id="29172.A0A0D8Y630"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="351" mass="40995" checksum="2A84E99F49037A29" modified="2015-05-27" version="1">MGKVPPRSPKYYSSDASKKDSRHECYLVNVTQQFQSVPPPKRNKATFMAAISAFKEHNPRGHVEFINTALKFIKDYGIHKDLDVYKALLNVFPKGKMIPQNVFQRMFMHYPMQQICCVKVLDEMEWHGVQPDKEIHDIVVNVFGKWNYATKKIKRMLYWMPKLKHSNKYLDRRIVEGQLLSSAELAGIALKMMIPDPGTSVSLIKITQDDIVDGWLAFGQSSTQKKLINELSDGTEIFIDGPFRVYVMEHQVQYIVMSFKPTHEQQDDDFEVEEFEEDLSKLFIEWKNEKHKRFRSVHEQKNETILALGAMFRQDNTTASLWLERFQYENPSLSRFKTRIRLDKGAPYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6F8</accession>
    <name>A0A0D8Y6F8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:neuron differentiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
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    </dbReference>
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        <property type="entry name" value="E5-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="145"/>
        </location>
    </feature>
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            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="19990" checksum="983AC25DBC398686" modified="2015-05-27" version="1">MSLNFSIDRLVKNVEKTESDDDKTTPIAQTLTYFDVLLPHVQMASANPFLTGLSATASNPNRLWSQQWIELLQQANSSQFGEVAAGLFLQPFRKNKRIRTAFSPSQLLQLERAFEGNHYVVGTERKQLANRLALSETQLIINLINVVYFIVELLWDYGNPVRLCCSSAIITSDRAAR</sequence>
</entry>
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    <name>A0A0D8Y6X9_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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    </comment>
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        <property type="protein sequence ID" value="KJH52623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="128"/>
        </location>
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            <end position="296"/>
        </location>
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        <location>
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            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39343" checksum="57F959008A233A70" modified="2015-05-27" version="1">MSTKRKSERKEAANGVTLSKEQDVIARYVRFNCPTNSTMFQGNEVHYFSGSKAVDTLMESVYGAKAKNEVAMLFPNRQAAVNYMRSLMSHQLFFRARKLVPKRKDDKEKKESSKPKVERPDNRKKDEETITETDAEDKKEDRKPKDLKLMEGSFLFQIFCDDKDVYVWVFDPTPLYKKVIGLLMVLGTILGCLFPLWPVWLRQGVYYLSLAGISAFGAIVIVAILRTILFGVIWLTTMGRHKLWILPNLTEDCGFFESFRPWYTYEYCPQSKKPGRIEKKKILKKAKESDHEDESKLLPSVSASGGDNLSQASRERHLFHHHQRLASETEEHKIPMLTMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Z0</accession>
    <name>A0A0D8Y6Z0_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KN716173">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="27"/>
            <end position="349"/>
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            <dbReference type="ARBA" id="ARBA00022487"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="356" mass="39926" checksum="4D5037802F8F77A2" modified="2015-05-27" version="1">MITRVLFTSICGIFAQATSNQNYIPVEVETRLGKIRGQQTIFLHKNVRSFLSVPYAEPPIGNQRFRPPEPKKPWTETITADVLSPACYQGRDMYNTSFWGSEMWNHNTPISEDCLFLNIWTPAEAYNLTVMVWLFGGGYYSGSPSLILYDGKALALFGNVVVVNVNYRVGPFGYLFMDDDEAPGNVGMLDQQLALYWIRDNIFNFGGNPTRITLFGESAGAASIVAHLIAPGSENLFKNGILQSGSLDNKWSMDTPARALDKGIQLSNLVGCNRTQVKDTIACLRSAPAQLLVDNIWNIELNFLEFPFVIVSRDRNFFRHKDGFMSLRTGQYVHHVNLMFGINHDEGDSSFSFCSL</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="222" mass="23943" checksum="B1BFE1CC25BF693C" modified="2015-05-27" version="1">MENVARPNISITRDYSPRPLISPVQSNSTTTNATEQAYQSTSSTNGTPVVISGGVSGMSVTALQQQPMQIYVDPASKQHYMAIETDQGMQLYPIQIQTDGPVAYSFAPDITSAMATNGGANQTFIMMATGEVEEGSSETLCTMPTARVQTSPSRSNISTRSQKNNELNSRQPQRNISAHTTTYVALAGQETHVQTRSSQKREGAGGKGNKEKVLSTKRPRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y869</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716198">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12617" checksum="2A01EF3B5E6364E1" modified="2015-05-27" version="1">MKLKVVQNVIHAIVACPITTVTFNTLSKRPFPDVFLFSRSHMMRSLSCHTVILLLSVIDFIKSVKIIDNGLAPPEIVHTPVALKHIDFVRLKYFIGFKKFVTVAELSIKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y891</accession>
    <name>A0A0D8Y891_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Granulin</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00819</name>
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    <organism evidence="7 8">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
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        <property type="protein sequence ID" value="KJH52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y891"/>
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    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Granulin"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
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            <begin position="32"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="26253" checksum="A9899D15599F0D1F" modified="2015-05-27" version="1">MACIKLLFFLHSLVFITDGNWGCCPIQNAVCCDDFVHCCPENSKCDEKSQQCINQIGERSPLWKKFVARKNEAICPDKRSKCPPGSTCCLLLSGKYGCCPVEHATCCADHLHCCPSGYKCDATGQRCIERETANVINSFRKHKATPIRKKSALHMVYSSERSVDSDIDLISCGYGKVCPSFSTCCEIVQQGRIHHMCCPLRNGECCKDTCCPFGYYCRPKGTCEKKAVRNVFIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8B9</accession>
    <name>A0A0D8Y8B9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8B9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8B9"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF11">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="332"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="559" mass="64127" checksum="0E1FFB15EF023903" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8D4</accession>
    <name>A0A0D8Y8D4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ku domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716157">
        <property type="protein sequence ID" value="KJH52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8D4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8D4"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="2">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="47589" checksum="13BE3C81FFF115D1" modified="2015-05-27" version="1">MRRESRISMKVKSDDNLNASNCVDLKDINQEKSRLQVYYFGNSKVTIGKEDEARYNYHNFNEGEQRGCMKLIQFTRREYIRECYFVGHNSFVAVPGWEKSSAERDSKEMHLTLSLMKAMLENDVVAICRYAPDAYKHLQLVALMPHKDKHLGYIYLKVFRLPFAEDMHPFNFVNVDSSCPKPSHKQANLIDELIDVMQFSTSSSPEPECVLNPIFQRQCTALKLKALNKNIDIGADSKIIEFVSPSEFLKRGLQPDPKLLENAKYVLSALSDDENGFILQEVTKSKRTKQEIRVEDISGWLAELESVNEENEMKNEGVKYMHSAQIRYIDRARARLQDNFDFHMMSLLDEVSVMTASEDEKANQLYEIALARLVSLRSLAIEFGTNSPTLISKQECVSSEYSESEANAVWLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8E1</accession>
    <name>A0A0D8Y8E1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716168">
        <property type="protein sequence ID" value="KJH52234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8E1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8E1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="277" mass="31321" checksum="8D0E6F572C283E20" modified="2015-05-27" version="1">MKSPWYLIDSVVNQVRFSGIWQKQYVIQSQRLLSDDGSRKHDAFLDGFHITPLNDTDMPQRSRMSFLSTEMTEAKQIGVRGLSCYGFRMIDGSFLYGPVALFPRTALSWRVNSPSDITPQSLSLFTMLEPKIDILVIGVGDRKNIDKVRAKIATFLKEHAIGLEIADTEDAISIFNFLNAEGRYVAAGLYPPDDMVVTDAEYGIAMNFLKPWDSLEENPLLIGLNDSIIQEEDVIGKIWNKCEVSKVLPDKCLAPTEKREEWHKLSGAQQKNSKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8K9</accession>
    <name>A0A0D8Y8K9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH52547.1"/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Choi Y.J."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="14">HannoverDv2000</strain>
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    </dbReference>
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    </dbReference>
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            <end position="31"/>
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        </location>
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            <end position="188"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52799.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="605" mass="68178" checksum="8B3B139D9F50BB14" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA26</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
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    </reference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="366" mass="40448" checksum="ABC40B3EA1DA37F3" modified="2015-05-27" version="1">MTQPAMIGDSVADFFGAPSRRGSYIIDAMNVNDLTAKLSTSTTTERTRKYGSRTTALEAIAEVDLTGRTILITGTTSGIGMETARALALKGARVIMANRNIVLSEELKTRILEEKPDAKIDLITCDLSSLQSVQAAANEYKSKHWPLHVLVLNAGVFSPSQKMTIDGLEMTFGVNHVAHQYLVRELLSLLRQSSARVVVVSSNAHSYTGLKPQMTIDEKLAKLCPTDSSEYGYKYYAYSKLCNVLMAMKLHRNEYNNGVSVYVLHPGSIGTNIARSYGFIVRLLKVVAKPFMKSLEQGAATTVYCAASPDVIGISGKYWESCWDDEKNLDVQLARDEQLQDALWDKTDKLLDVYEALRRPIMTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="399" mass="45526" checksum="A0264518FDBE2C33" modified="2015-05-27" version="1">MRLALDPDTHEAVVIMANRVISRCSIRTGKMSKKFIDDYISQQTFKNSNYVIDNDITSNELRESSDFYLLADNIAVLLTYNLENYHFSQYVLILSDNTGKATLTMKRTMTLPSLNSNLTVGMGLLNEGFVMATGYTGPEGIHRQVVGHLIAADPLKASILQNKDITPMIRQFERFLVKHDADLHIFASGILAEKNGLIFLLRSSEYDLFETTMVGRASFKSKGSMVRCELIPLDNSSVLFPRLLCIRHLRQVCHRDGNIWMTIISSDFEQLSTVRWRIYLSLLLYIIKVITILLRFVLWMRRVDRGVSLYLYMKVLRWIYGPSMIPVTAPPPTFNMYGLDMNSLKFKRVPIKPKLYSSENAFINYPLAIDCDRTGGVVTAELGSSLRQLMISIYTKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD14</accession>
    <name>A0A0D8YD14_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD14"/>
    <dbReference type="STRING" id="29172.A0A0D8YD14"/>
    <dbReference type="OrthoDB" id="8916892at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="14072" checksum="80853651C1E69A1C" modified="2015-05-27" version="1">MTSQSDEENEVHPLVSNLLGQKFIPRTGQVLRYDREEMIRLSTTPLSMQRPDNLSVDFDGDDGKFSPFKWLEYRWEVEGIKNRAPAKKLQDALSTVSSLSMAHCLLIEQFAAYHQKILDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF36</accession>
    <name>A0A0D8YF36_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_00557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF36"/>
    <dbReference type="STRING" id="29172.A0A0D8YF36"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10 11 12" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RhoBD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="150"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="264"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH53246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="375" mass="43436" checksum="7A7E08649799C418" modified="2015-05-27" version="1">MNHLNEKTAVIEEAEAVIVDLKRKLELEKAHKRAVIMKLEEEMAKRVVDKKGGKHVSKSDLLKKDREIIQHQQENRRLLARLDEVYNDRERMMTDMTRELEEEQRDNDALRLEVKELKEELEEMKRRRDGTIDDSRSVGSRDSIPHTIRNLPHAGWVSMKPEKRSAGSRKLKWVNYYAVLNQVALQLFPDEKPHSSAVMSLDTRQLCHVRLVTAADVRVADAEQIRRIFHIMFDDRDNGATSRNASTNDLSIAAASQKDESWKSHDFQELAFHMSTYCDICNKKLSDLVRPPPAYECKNCRLKIHKEHVNSSQLITCKYTGIVREWLLMALTKEECNQWVSILQRVMALQGSNPISRVSSKIRHQPSHSHSSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YG31</accession>
    <name>A0A0D8YG31_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YG31"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="9016" checksum="8859A20EB5B27816" modified="2015-05-27" version="1">MVLRVYLNPLLTLMCVASCSWVFGRFCALFYIMEERKAHSFIVDVELMALVVAIMEPTSYAIHRILETREYPEIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5S0</accession>
    <name>A0A0D8X5S0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rapamycin binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720051">
        <property type="protein sequence ID" value="KJH39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X5S0"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FRB_dom"/>
    </dbReference>
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        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FKBP12-rapamycin binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11374" checksum="4F3FA48635925AD9" modified="2015-05-27" version="1">MVSEELVRCAILWHEQWHDALDEASGQYFQEKNTTTVMETLEPLHKMIEKGPTTLKEQSFNQVFKKITAQLRQLTSLDLNYISPMLINAKVREILSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6Y3</accession>
    <name>A0A0D8X6Y3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aurora kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_13796</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="KN717442">
        <property type="protein sequence ID" value="KJH40263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6Y3"/>
    <dbReference type="STRING" id="29172.A0A0D8X6Y3"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="53"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH40263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="42336" checksum="7BF5598B5ECCDB79" modified="2015-05-27" version="1">MSKTDSAPTSEMGCHSETSKNSTRSDITDSTLSRQAYQIGSQNVFRTWTIDDFEIGRILGRGRFGSVFAARSKQDDVLIALKILFKEQIDKYNVRHQVKREIKIQHHLRHPNILRLIGYFHDPHRVYILLEFAHGVALYDRLKEKGRLGEGEAAKYVHQLADALKYCHTKNVIHRDIKPESVLIDRDGNAKIADFGWAVESNSPQETFCGTLDYLAPEMINRSAYNHTVCFYLVSFFMIHIVKKGHIIQKTSDRWTKRQFGELQRDVDNWALGVLLHEMLIGRTPFESTDENQTLNAIIECKVAIHDDLSEGPRDLIKRLVVKKPFMRLPLSEVLTHAWVVYMITRSNSFLNRHSFHRRISGSSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X774</accession>
    <name>A0A0D8X774_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722511">
        <property type="protein sequence ID" value="KJH39652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X774"/>
    <dbReference type="OrthoDB" id="5875501at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="98" mass="10875" checksum="2B38D21D0FA2826D" modified="2015-05-27" version="1" fragment="single">MVDTAMLSEVRLMDRLDYVVNSLPISSITKLSTWTSQVVSNARVGLIVENISELNSLLPIVSSLLLSLSSAISNLFQAFIELYYAIVSMSMQLFEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7H4</accession>
    <name>A0A0D8X7H4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_13543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717162">
        <property type="protein sequence ID" value="KJH40500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7H4"/>
    <dbReference type="STRING" id="29172.A0A0D8X7H4"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011:SF6">
        <property type="entry name" value="HIGH ZINC ACTIVATED NUCLEAR RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46011">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-86-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="152"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH40500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="392" mass="44890" checksum="EADAFE0AF810518C" modified="2015-05-27" version="1">MTVFSPTIHCQICSDSSDGLHFAVHTCRACAAFFRRTVALNLRYECRHNGMCRIEKSIRNMCRSCRLKKCLEAGMQRSGVQLPRDGIGKRTKNPSKHEPDQRHSIKTKLPKLDIPTASCVELLQCPTTVDMMPLLPTIVNMNPSASVVILPRMLQGYQHFLTIRRTTTTLVGKESRSEEFGAFATNELRTSNFDSSKKVCQLEAHLITDIINTYFYPFDKLQFTQKVILFKNFFCYLSHTDRAYQSYILFGQDECNDRLLMPDGGFIKCSELERFYANAKGVHSQPKEAAKVFRPSMEFILNVIIPYMKRIELTEIEYVAILGFLLWNEAVPDISRDTITIIHLTKDTLLDELHEHYQCIGMNGHEITKRIGKLMLLLPHLTVGSTKSIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7R3</accession>
    <name>A0A0D8X7R3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717090">
        <property type="protein sequence ID" value="KJH40600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7R3"/>
    <dbReference type="STRING" id="29172.A0A0D8X7R3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7804" checksum="38E833BF0563F0AB" modified="2015-05-27" version="1">MITWYWNGDVMHSNWQGWSLREEGGDKKIVSVATRTTVHESGRAVCVATNDGSSATATIECFEYIPADYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7U3</accession>
    <name>A0A0D8X7U3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717079">
        <property type="protein sequence ID" value="KJH40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7U3"/>
    <dbReference type="STRING" id="29172.A0A0D8X7U3"/>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="33064" checksum="7AEF7DA0AEF01080" modified="2015-05-27" version="1" fragment="single">MLFVLSEIEQRWSDISLVLSKQLLKNEEIRKDDNILKTMAYIRDLVYKWMNQASTFEAFGAVLTVIRNLSMVDLIEKFFDEHSLNGLSDVEQRPSLTSKYINLLLVVDSKRLLRILREMVSAWPKKLGITSARDLMSCVAEMVKLARCHPNIGKACVGFYKSDLGMVLSSEFGFLLMFAFCNIDRYKTLMMTELTKAFQKLWNFKESVHEFGWIENSGVGNVVAIVEDQITCLVQRLEEDVEAFELLFEPTVLLLQSLLKLPSTRDITIVDGRVADGCPIWLFASKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X891</accession>
    <name>A0A0D8X891_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_13279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN717025">
        <property type="protein sequence ID" value="KJH40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X891"/>
    <dbReference type="STRING" id="29172.A0A0D8X891"/>
    <dbReference type="OrthoDB" id="5912168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012294391" evidence="3">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="31129" checksum="7276BD6CA305F934" modified="2015-05-27" version="1">MIELLMLFILSIIEARLPADFYKSFHGNLDKSDKMSLPRICGKHFLPKEIQGRSLGSIIVAEDEYPWTLALTREAATCSAVLISRRHVLTAAHCVTFPGPKPKDKNAKCPYTVLRPSQISIYPGKRVKDVLNIPLFTASFSVVNMTVHSRYDPCRRGGDIAILEISPNMFSEGSPICMPKFYQATPHQLMSAGFGLNPDHPGKGYLQAVNLTFKGISPYDEIETYTVDRIPCAGDSGGPLFAVIDGKYTLLGIAARSVACLKNNKGWYVLKIRNAVVHQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8B1</accession>
    <name>A0A0D8X8B1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717615">
        <property type="protein sequence ID" value="KJH40189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9A5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335640" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18687" checksum="8DDD4ED9E01FCEC2" modified="2015-05-27" version="1">MTMYVLFFMMVLIGTLAKEHRPKLPHVDDVTLHLPVEYREELEKHHWIYGHLWDSGLENLVLKTFNWSDPLDKVFISYDVYSTYYMFGSNGSNIDDAIKKVPKEFWEKIGELTRRRFLKKFGCNLKKFPTDDGYYCYENFMHDPDYRPDPTAAIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9C9</accession>
    <name>A0A0D8X9C9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Receptor L domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_13677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717283">
        <property type="protein sequence ID" value="KJH40372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9C9"/>
    <dbReference type="OrthoDB" id="5875632at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="2">
        <location>
            <begin position="71"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="497" mass="56548" checksum="BA9B817A2C931279" modified="2015-05-27" version="1">MNHFKDFTPIRGCKQYIANNSELCVGNSSFWREVFGDIDIYNNRMHCPDQCDGGVVNETYLDSTAACEMRIGDVVIADLTELPSNIDVLYNTRSIEGRLIIANNTGLGNFDYFKNVEVIGSPLLEGDMAPLYVEGNNDLQSLELSKLKKVLLHENGLLIVLRENDLLDMSESEMDSLIAIAGGSDFVDIHCQEALLRNVRAAVLLLPLILMILMMLYSAMKLRGYQFSRALSVKSRKILADMSKEILAKNPLVWMIQDRPLIWRYGENDPERNTIKQLKTQHENYLKEYAIEVLPNARIPTTSDRCIADRLFQIIKHEEILAIATEDDISLVIPALPSDVGKGETYNGSRVNGSSITLKLVDVKSTNDQTQQYTYNVTIVQNAKTIVKRLKIYLYVWDSLRLPISFDELLEAITLSTKWRMTCVSDRRKEIFFLLHMIFTYVTVLEQSISVVKAFQFHTDHFNGAPMDRCEMLCVMAFILEWANQTNSIPIEIAEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAF8</accession>
    <name>A0A0D8XAF8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDK5RAP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_12465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Potential regulator of CDK5 activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716799">
        <property type="protein sequence ID" value="KJH41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAF8"/>
    <dbReference type="STRING" id="29172.A0A0D8XAF8"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="123"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="455" mass="51294" checksum="04D6D0CD20A10AE4" modified="2015-05-27" version="1">MEIVRSLLKNNDYSETSDIETADIILLNTCSIRENAEEKVWRELKRIRNVVRNKPIVGVLGCMAERVRHDLLSKNGLVDIVAGPDAYRDLPRLLAVARAGSSAINVQLSVEETYADIKPVRVNDNTKTAFVSIMRGCDNMCSYCVVPLTRGRERSRPIDSIVDEVRRLSDEGIKQVTLLGQNVNSYRDMSVSTYFTGSGVQTTTVPGFSTVYKPKIGGRTFLTLLEKISEIDPEIRIRFTSPHPKDFPIEVVELIRERTNICNQLHLPAQSGDDTVLERMGRGYTRDLYLQLVNDIRKILPDVSLTSDFIAGFCGETDEAHENTVKLMRDVKYTFCYVFPYSMREKTRAHYHFTDNVPLEVKKKRHQELASVFREQAFAIHSSLIGTEQLVLVEGISKRSATALQGRADSGTKVIFENAETYRPGDYVVVKISGCSSQTMCGVPLRKSTLKEFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAM7</accession>
    <name>A0A0D8XAM7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717008">
        <property type="protein sequence ID" value="KJH40807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAM7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="60" mass="6783" checksum="24BE2CF0DBBF8926" modified="2015-05-27" version="1">MIIKDYYAQLPPFQGWAMSKPWHLILKYTSVTQEEKAHGSDGTMDEDSVSANTSVAEQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCE5</accession>
    <name>A0A0D8XCE5_DICVI</name>
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        <submittedName>
            <fullName evidence="10">Inositol transporter 4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_13929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XCE5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="153"/>
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        </location>
    </feature>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
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            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="382" mass="42235" checksum="DBB7B5C4D753EF80" modified="2015-05-27" version="1" fragment="single">MSSGFLFGYDTGIVSAAMLYVPENQGMKPMKYIWQEIIVSVTPGFAAVGALLSASGSDRFGRKKVIVVASIVFTIGAAICGIAWTKMILVIGRVLLGIAIGFASMIVPVYVSEVSPSHIRGRMVTGFQLMITIGLVVANVIGGAFSYVDPENIGWRLTLGFAALPAIIQFICFIFLPESPRWLFEHDLPEQAEAVLKKLYNGDNEWVQYEMAEIRQGHKMEQIAKAEHAEGGSILRRILYTPHVRKALIIGSLIQAFQQMSGINTVMYYTGKIIQSSGVTDSHLTIWITVGTSSINFLGTFIPMAMVERMGRRVLFMISVICVILSLLAMGTSFVLINRDSALTLHDRSFVNQSYPDIIQKSYEQYRVVVPYQARNKVICLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCF6</accession>
    <name>A0A0D8XCF6_DICVI</name>
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        <submittedName>
            <fullName evidence="11">ABC transporter transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_12695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XCF6"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
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    </dbReference>
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        <property type="entry name" value="Protein CBG24505"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="47"/>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
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</entry>
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    <accession>A0A0D8XD68</accession>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
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    </dbReference>
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        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="247"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="311"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="488" mass="55811" checksum="AEB50913D2DA3764" modified="2015-05-27" version="1">MEEFHAKGSVGLIACCQCGLPIQPNTANMCSGCIRSRVDITEDISRTSCIYLCKFCERYFVPPNGWVRAAPESKELLSICLKKIKPQLLKVRLTDACFVWTESHSKRIKVKLTIQKEVFSSTILQQAFVVEFTIHNQLCDDCRRAEAKDYWRACVQIRQKAEFKKTLFYLEQLLLKYGAHNQCTGVRPVPTGIDFFFAKLQDARKFIDFLIAVLPCKYQYAQELVSHDTKNNTYDYKHTFCVEVVHICRDNVVCMPKRVAQRLGNMSQIAICLRVSNVISLIDPSNLQMADIQAATFWRDPFDSLCTYKQLSEFYVLDVEIVDLDRKAGHGYVSKKHVLADVWLVRSNQVGSSDAQTFSARTHLGHLLNPGDLVLAFDVRNSNVNNSVFDEMKQEEIPDVVIVKKRLVIDGNIVGNETDSVTDEFQRFMDDVEEDPLIREKINIYKDHSGGKHEDDSFDDEIPDAPTLEEMLDDLVLEDKEMQSDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDW8</accession>
    <name>A0A0D8XDW8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716620">
        <property type="protein sequence ID" value="KJH42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDW8"/>
    <dbReference type="STRING" id="29172.A0A0D8XDW8"/>
    <dbReference type="OrthoDB" id="5831869at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF493">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GCY-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23294" checksum="140378A28746E972" modified="2015-05-27" version="1">MSSRSLQNSIASSSRVTIDSKKVRTKDFNNYEDTQHQAFYVFGEEFVVARKHAARLTLTKADNLMLRKMRNIDHDNLCRFIGLSVDGPQILSVWKYCARKSLKEILGKSAIQMDWFIKYSFIYDICEIKVTFFGLNAIKATEIREPMDNLWLAPEHIRDPLLPPTKEGDIYSFAIICSEIITWKSAWDLENQDYDINGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFK4</accession>
    <name>A0A0D8XFK4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_10599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716565">
        <property type="protein sequence ID" value="KJH43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XFK4"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="213" mass="24438" checksum="FF3D1DA16A013707" modified="2015-05-27" version="1">MPLTSKSQLTIEKSPAYFHSRTAAKRIRALNPTMKIIIVVRDPVMRAISDYTQASSKRKVLGRLPTFEEMAVGDCAPWLKINCSKKIDGVNVGWGAIRIGLYHLHMKRWLDNFPLHQIHIVDGERLVSDPALEVSQTERFLGLNPVVKKEDFGVDPIKGFPCIRRHNGTLHCLGKTKGRKHPHVVPEVLLRLMRFYDTANQKFFKMINRSFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGU2</accession>
    <name>A0A0D8XGU2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716606">
        <property type="protein sequence ID" value="KJH42964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGU2"/>
    <dbReference type="STRING" id="29172.A0A0D8XGU2"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
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        <location>
            <begin position="363"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="546" mass="63030" checksum="031E3959B3B6C17F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH02</accession>
    <name>A0A0D8XH02_DICVI</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="226" mass="25309" checksum="F4C1AB239332ABD4" modified="2015-05-27" version="1">MEKILACIKLNGLNLSKQQLMDQISPIYANIFYYSDISSMCEKICNTVRNCSKQNYLDQMISDHCEVMGPHTISCVAHASTNHFEETNSGKSSFRPNISSLGQHRKASESNDSQHLSHEGLTINNVIEQNISQETCTSFLADGCSHSCDSRLSGSQNKELTPSFQRSQTASDCYLPSEFQLSTGLIDIVELVPKHGSLKVIVVSILIFCFTFRFSLQSFYPFLCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH74</accession>
    <name>A0A0D8XH74_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">DICVIV_10888</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="family name" value="OtherNon-catalytic_C"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
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        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
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        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
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            <end position="604"/>
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        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00005964"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="604" mass="69271" checksum="5A0884076E73527A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHW6</accession>
    <name>A0A0D8XHW6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ets-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_09789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716492">
        <property type="protein sequence ID" value="KJH44188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH44188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="22588" checksum="B260569A6D089E8F" modified="2015-05-27" version="1">MRSGEIHQKENLPSIARNQNKHTSTHVSLPYIVESRRYSEPPPPPSHLQTQRRRSREVTGQVTYLWEFLLRLLQDKEYCPKFIKWIDQAKGIFKLVDSKAVSKLWGMHKNKPGMNYETMGRALRYYYQRGILQKVDGQRLVYQFVDVPKDALQESSFDPSTDCAVSDILEDLKNPSERNNEVHINSSLSVPQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIK4</accession>
    <name>A0A0D8XIK4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716704">
        <property type="protein sequence ID" value="KJH42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XIK4"/>
    <dbReference type="OrthoDB" id="5920525at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="436" mass="50825" checksum="56D6E3104ACF8080" modified="2015-05-27" version="1">MAGEEESVHQTEKIYVDSHLTEQQSWEDFCTLESSGVSEFTGSKEEEKRQESEVIWKKFEETIEKREDGYYVRLPWKDNANTLPANKGMAIQRLQSTVNKLKSHPTLFQQYHETIVQQLNQGIIEEVEETNNSTNLKEIIHYLSHHAVITPNKETTKLRVVFDASAHQKGQPSLNEVLHQGPLILPQICDILLRFRIGDIAIISDVEKAFLQIRLHEKDRDATQPTYKHTSILMTAQADEDKELLDWRRHNRLKLAQRTIAYVLRFIKAIIDRLNQQLKDRIQHNIPEVMLMASTPYITAAEYELALRVLVRNHQNSYDALIWNSPNQLNLYRDEHGIIRCRGRLSKACIPFNAQQPIFIVSRTKLAEMITQDAHLPYHSGTSQTMANVRQKFWIPKLRQQTRKVLRRCVACQKMNNLPYKYPNMDDLPESRIPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJ08</accession>
    <name>A0A0D8XJ08_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ER lectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716461">
        <property type="protein sequence ID" value="KJH44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJ08"/>
    <dbReference type="STRING" id="29172.A0A0D8XJ08"/>
    <dbReference type="OrthoDB" id="239053at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum lectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="116"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="351"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="519" mass="59421" checksum="0E7F1602C3C74C81" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKF4</accession>
    <name>A0A0D8XKF4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKF4"/>
    <dbReference type="STRING" id="29172.A0A0D8XKF4"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000201">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="35278" checksum="A1567D5DCA3F692C" modified="2015-05-27" version="1">MLLPCGIFKYFFSTITQEAKHIPKSKMFKVVEVGARDGLQNEKQIIPAKDKIDFINKLSHCGFQVATSFVSPRWIPQMADHQEVIQKITKCPGVSYPVLVPNLVGLHNALKSECVKEIAVFGAASNSFSRKNTNASIEESLKNLQDVTTVALKEGLRVRGYVSCVIGCPYEGKVDSAVVAKVAETLLEAGCYEVSLGDTIGVGSAGSVASMLEVVLKSIPAEKLAVHFHDTYGQALVNVIVAIEKGIRVADSSIAGLGGCPYAMGATGNVATEDLVYMLHDMGFYTGINLSKLIETSTWICSKMGRPNASRVAKALMTKQLDSKDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKN6</accession>
    <name>A0A0D8XKN6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_08836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716426">
        <property type="protein sequence ID" value="KJH45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKN6"/>
    <dbReference type="STRING" id="29172.A0A0D8XKN6"/>
    <dbReference type="OrthoDB" id="6286622at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="155" mass="17066" checksum="265B2AC35794A8BE" modified="2015-05-27" version="1">MKHSICLIYIERANNQLTFQLTVRLTCVTTAVHAYRLIMEPKISANVPLVSPELNVNMVHLDPYVNECVVDNGGCHHDCVNTIGTFYCRCWSGFELEANGKNCKDIDECATSNGGCSHRCVNSPGGHRCECPPGMQVNSGGRICVGKFQKFIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL29</accession>
    <name>A0A0D8XL29_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716598">
        <property type="protein sequence ID" value="KJH43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL29"/>
    <dbReference type="STRING" id="29172.A0A0D8XL29"/>
    <dbReference type="OrthoDB" id="10066279at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="167" mass="18720" checksum="915E7893073F8A84" modified="2015-05-27" version="1">MVPVYLSGAQKHLFFSSLKQLDPNEPDGKHVCSQCNEVVPNLREGRRHMVTHIRVMRLRCSLCGAGSFFCTDLRVHLMEGYCEKLHRAPEGVVNSNRNPCMTKEQADSLSELVDPVNPGRVMYTSGKIVSAKSRISYYPDPIIEERILGPGRVFGRSSPGRMKCGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLL5</accession>
    <name>A0A0D8XLL5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716402">
        <property type="protein sequence ID" value="KJH45533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLL5"/>
    <dbReference type="STRING" id="29172.A0A0D8XLL5"/>
    <dbReference type="OrthoDB" id="6380629at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060102">
        <property type="term" value="C:cuticular extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042329">
        <property type="term" value="F:structural constituent of collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF393">
        <property type="entry name" value="CUTICLE COLLAGEN ROL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH45533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="332" mass="34122" checksum="B05BF48235711316" modified="2015-05-27" version="1">MSIIGATSGALLFTGTTLIISLFAAAAIYVQINSFRNELDTEMNNFKALTDDLWIDMIGLGAGTPTNRVRRHIIDSQLETEVQPSVPEYGGYNAAGSQIPQLIQATPTPRVIVVNSRCICVNENPCPPGPPGPVGEQGAEGLDGLDGVPGFDGFDAEDSSSEAPKGCFTCPQGLPGQQGPVGPHGIRGMRGAKGQPGMPGRNGNPGMPGEMGPTGPPGPDGEPGKPGDKGDDAENPVGIQGPRGPPGEQGLEGPEGSPGIDAYPGLPGRIGDPGVPGYQGAAGPDGEEGPQGPPGKPGRDAEYCKCPDRDSIANNLYNPGVTIGYRRKKHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLM9</accession>
    <name>A0A0D8XLM9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty-acid and retinol-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty-acid and retinol-binding protein (FARBP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716402">
        <property type="protein sequence ID" value="KJH45548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLM9"/>
    <dbReference type="STRING" id="29172.A0A0D8XLM9"/>
    <dbReference type="OrthoDB" id="5808308at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008632">
        <property type="entry name" value="Gp-FAR-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31418:SF7">
        <property type="entry name" value="FATTY-ACID AND RETINOL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05823">
        <property type="entry name" value="Gp-FAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19765" checksum="DCCF957E8171560C" modified="2015-05-27" version="1">MVFRIIISTVLFCIAFAVYDIPAEYKDLLSQPAKDYYDKLSDLERNAILEVAQIYANTGDSGKVIQELKKKSPELGDKAEKLFNVFEKSFKSLGDEAREFAMKVFREASKMFVSVVSSGQKPTINEIRNKVAIGVKKYNALSETAKAEYKQQFPVFTSLFRSDKFQQMIDSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLQ5</accession>
    <name>A0A0D8XLQ5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716457">
        <property type="protein sequence ID" value="KJH44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLQ5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="8024" checksum="4D500E779CB35B15" modified="2015-05-27" version="1">MYLLSDVSWKIYNRDLRVVELILDINKCGQLPIHVRESQHRLQRFFCVVHRDRTANIKVRSFPLPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMT3</accession>
    <name>A0A0D8XMT3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716536">
        <property type="protein sequence ID" value="KJH43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMT3"/>
    <dbReference type="STRING" id="29172.A0A0D8XMT3"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="130"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="39631" checksum="A50EA8A470B8A3B6" modified="2015-05-27" version="1">MVSSCQGLRDTLITLSNPCDVVELQMEIRINGRTESTAETLTPPTCDIALSSPEVDVLIKMEQLNRSNEEDTRSVASRKSGSSGSPKVHEPSPTEDDEEDLWSVWGDVIRNWESEVKKNPNAIKMLVKRGIPQHFRTIAWQLLSNASISSIHEVYSDYMRQSSVYEKVVHRDISRTYPELEFFKDGGRGQASLFNVIKAYSIHDKEVGYCQGSAFIVGLLLMQMPEEEAFAVFVRLMENYRLRELYKPTMTDLGLCMFQLECLVQEQMPDLHAHFNNMGFDTSMYASSWFLTLFTTTMPIEIANRIMDCFLVEGMEFIFRIAMSILQQARIDLLRLDMEGMLKVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMW2</accession>
    <name>A0A0D8XMW2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="16">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_08810</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="16"/>
    <dbReference type="EMBL" id="KN716424">
        <property type="protein sequence ID" value="KJH45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XMW2"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein-tyrosine kinase 2-beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="169"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061333"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="512" mass="58996" checksum="BE6AF6E1C16314DE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN86</accession>
    <name>A0A0D8XN86_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_07928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716374">
        <property type="protein sequence ID" value="KJH46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XN86"/>
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    </dbReference>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="38"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="18320" checksum="42C56F24CB5B0823" modified="2015-05-27" version="1">MLCIISKIEFFQGPSSLFVFSEDNFIRRNAKAIIEWGPFEYFILLTIIGNCVVLAMEQHLPKNDKKPLSELLERTEPYFMGIFCLECALKIVAFGFIAHKGSYLRSGWNIMDFIVVVSGVVTMFPVSPTSAGGGSAQVETVDLRTLRAVRVLRPLKLVSGIPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN89</accession>
    <name>A0A0D8XN89_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716418">
        <property type="protein sequence ID" value="KJH45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN89"/>
    <dbReference type="STRING" id="29172.A0A0D8XN89"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="189" mass="22047" checksum="8447E8E3A9961165" modified="2015-05-27" version="1">MKVDEFIIYESTIEGYNCSNGSRWMISVDCEDARMESLGLITGIVSLLLFLIPLLWQLFHNYKAKATSGISHISLLFWKASSSVIAYKAWLIFESYTDMNYERKSCEGLSLLMFFTIVAANLTYGLFILMATTNWLLFLRHFPWLAGSFGCVLFDIIVISQYYYYRDRRERERDSAVVDLIEDVDYDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNX1</accession>
    <name>A0A0D8XNX1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716358">
        <property type="protein sequence ID" value="KJH46328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNX1"/>
    <dbReference type="STRING" id="29172.A0A0D8XNX1"/>
    <dbReference type="OrthoDB" id="2195551at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22741" checksum="04298CFDC8B76586" modified="2015-05-27" version="1">MMDGDVQGEDYFIHNTTNITNVWSLGFHHSIVLQYYKCNCLQSIPDVTNFCADDSLLNVINTPEEAAVRRRGNLRGQFLPEAIDDGSSGSSKSSEIRVLTPVDSVQRERQARYCHYILNKGGGRKDISRTNFSRVGDSSRFERNREEEIRNVGTFENLREGLENVAKVIKKSSRRDAFMDESDLQLESDKGNFESSENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPR3</accession>
    <name>A0A0D8XPR3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_07403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="KN716348">
        <property type="protein sequence ID" value="KJH46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPR3"/>
    <dbReference type="STRING" id="29172.A0A0D8XPR3"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="11">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="11">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="47456" checksum="0F41867B749D6FE8" modified="2015-05-27" version="1">MMGLFAKKKDPKEQVREMQRKMRNEIRALDRQVYSIQREEQKVTKEIKEAAKKGDRDVCVVLAKSLLQSRKAVAKIHMSKAQINSVIMCMQEQLATMRMAGSLQKSTQVLQTMQNLVKVVYGFCLQHVTMREMSQEMMKLGIIDELIEETMESIEPADLEEQAQDEVDRILWEVTAGELGKAPAAVTSELEMSKFYAVAHGFQRGIYEDWNDAKRQIDDFPQPVYKKFSSREQAEEYLTARQPKNIESVFPEPNKEKYYAVARGHTVGVFDNYEDVKRYIDGYPQPLHKKFDNLDDAVAYFKKFFFGSVEGDKVNQGKVLPAEGSSKKKEDKGMVYYAVARGHATGVYTSWEECKKQTVGFKGAKFKKFESREEAIMFSEGKTLKQIEEAVGSQKRCASASENNDEVVQKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ19</accession>
    <name>A0A0D8XQ19_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716338">
        <property type="protein sequence ID" value="KJH46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ19"/>
    <dbReference type="OrthoDB" id="5863096at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004296">
        <property type="entry name" value="DUF236"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21592">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21592:SF4">
        <property type="entry name" value="MATH (MEPRIN-ASSOCIATED TRAF HOMOLOGY) DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03057">
        <property type="entry name" value="DUF236"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="251" mass="27238" checksum="803B7F496B2E25DA" modified="2015-05-27" version="1">MTMSESHSNSEKEKSEPKRRASGGRKKKSPSHSPPAKKIKKPTPKNRGGEGDHSRKKPRVAAGGRRAHSRGQKAAGGPAKKHGPPPKPKMAGTFDPNYQTLAGMNNDDVFKRKDGAECAGGGAANIPQAPPPKQVQMAGAFDPNYQTLAGMKNEEVFKRKDGGDFGGGGGNRPQPPPIKQPQMANAFDPNYQTLAGMKDEEVFKKKDGGQEIRKPDAHQFAGAYDPNYQTLANVKNDCFEEKKKQPDFQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRI6</accession>
    <name>A0A0D8XRI6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Citrate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_06786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRI6"/>
    <dbReference type="STRING" id="29172.A0A0D8XRI6"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072350">
        <property type="term" value="P:tricarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="13">
        <location>
            <begin position="64"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="14">
        <location>
            <begin position="709"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="905" mass="99674" checksum="42242A854CF52386" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRI8</accession>
    <name>A0A0D8XRI8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716314">
        <property type="protein sequence ID" value="KJH47283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRI8"/>
    <dbReference type="STRING" id="29172.A0A0D8XRI8"/>
    <dbReference type="OrthoDB" id="184109at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="12397" checksum="4DF173DFA8FE56F3" modified="2015-05-27" version="1">MALVIIDYAVDGHYKQSFVIASGGGWRVVEGAVEGQTQTDLPSVFKEAYFAHPIDLHLATKTIQGWPRIQLQVWHYDTYGRQELLGYGSLFIPSTPGEHQVCLKMFKIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRR9</accession>
    <name>A0A0D8XRR9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, C3HC4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_08871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716428">
        <property type="protein sequence ID" value="KJH45086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRR9"/>
    <dbReference type="STRING" id="29172.A0A0D8XRR9"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF41">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="410" mass="44776" checksum="3FDCAEE186EAC62E" modified="2015-05-27" version="1">MSSFFPYIFVILYFYYNNVIHSNEYYGRIGSCSVAILVHSWKLCHPLVAMDPLPATLPLAAASRNANSAAQQFAYAAATLPGEGAGASTYIPLELMMYRHRHHPVATAGANLVIPQNPVPPCLLSAQPMMCQSCIYSSPSQPCSIHHAPIAYGQATPSYTIVSQQQHAPPQQQQSQQSTITVTPQQQHNGHQQIINEPSQAVQPEPMIQPTAPSVPNVQQQLQSEQPPSTSQLVAAAAAAAAVSNNGSEIVNGPPPQTQCVHCGTRGACPACVPCYCAYCPHSATNGRLELHMLVNTGMPPELLGMVERPLDRHHMFAAPVAEPLPVGASPQDIEKCTEKISFIKDLEVPENEQERCTVCLCEFETGEEVRNLRCTHIFHVNCIDKWLVYNKKCPVCRLDVDKQKAVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRW0</accession>
    <name>A0A0D8XRW0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_06531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716310">
        <property type="protein sequence ID" value="KJH47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRW0"/>
    <dbReference type="STRING" id="29172.A0A0D8XRW0"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051446">
        <property type="term" value="P:positive regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="272" mass="31495" checksum="0D2039CA07D832CE" modified="2015-05-27" version="1">MDNYKKGIPATVIREISMLQELKNPNIVELIAISFQDNRFYLIFEFITLDLRKYLDQIPADELVPRDTVQRFAFQICQAMCFVHQRRVLHRDLKPQNLLVDENGIIKVADFGLSRSIAIPLRVYTHEVVTLWYRSPEILLGSPRYGAAIDVWAVGCILAEIAVKKSLFKGDSEIDQLFQIFKLLGTPTEKMWQGVNQLPEFKARFPKWKNNEINARLKPYCNAELIDLIQLMLKYDPSLRISMKNALHHKYFDSVDTSSVPAGNYRGELLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS92</accession>
    <name>A0A0D8XS92_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_08721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
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        <source>
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    <sequence length="51" mass="5592" checksum="8A7E143E6B6F88A7" modified="2015-05-27" version="1">MFSELSVDSSWPSSSSTNLGRLRSSLGHSDPQISTSCTYLPLLKNDKKSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUD5</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">HannoverDv2000</strain>
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            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716311">
        <property type="protein sequence ID" value="KJH47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUD5"/>
    <dbReference type="STRING" id="29172.A0A0D8XUD5"/>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH47364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="20179" checksum="BFDA1D6BB576BE90" modified="2015-05-27" version="1">MDIWSLVKKKLAENAERTTNMENNEEKKQDQNDTSRRRATHIIVCGNSQSGKSTLINKFLDKNEEHKETVALEYTYARRTRGNNKDICHIWELGGGTSVTQLLAIPFTEENIERASFVIALDLTRPNELWITMEKLVTEAQRYIKTVIKNLDQNKQAAIKNKRSYMNQKPAIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUH3</accession>
    <name>A0A0D8XUH3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="3">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="3"/>
    <dbReference type="EMBL" id="KN716274">
        <property type="protein sequence ID" value="KJH48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XUH3"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040477">
        <property type="entry name" value="KDM4-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="12">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="157"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="554"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="832" mass="95282" checksum="D14B79A48E73BCED" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUJ9</accession>
    <name>A0A0D8XUJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    </evidence>
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    <sequence length="3689" mass="415184" checksum="E163AC4F5556F6AE" modified="2015-05-27" version="1"> </sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    <sequence length="462" mass="51134" checksum="83D278FCBB3935C4" modified="2015-05-27" version="1">MSDVGLLVVTSRNIAKLTALLAIAADSISSRLYIRVQGLCLDSLLPSLYLQSSIHCPRLDVRVLLGRKTPFYSRLIGDENTHDSPIILPKYKKVVLGGTFDRLHNGHKVLLSKAVLLASECVICGVTDKTMIEKKCLWELIEPVSTRIRAVEDFVADVSDSVVCLAEPIVDPYGPSTRISDLEAIVVSKETVKGGEAVNRVRKDKNMSQLDMIVIDLVEATDEVMKESKISSCSLRRQDLGKLLKTPTPHPERPVRPYVIGLCGGIASGKSSIAKILKEQPGFEVRIVQVIDCDKLAHSCYEPGSKLIQAIGSHFDGVVKNGVVDRKILGAVVFGNEEKLKLLCKLVWPVLMEKIKNMVAVSKSDVVVIEAAAIVEAGWHTYMSELWTVFVPHEEMVKRVMERDGLAKEQAEVRIKSQLTNKERVAHSHVVFCSLWAYEETRAQVERALSGLRTRIFSSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUX6</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">HannoverDv2000</strain>
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        <location>
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        </location>
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            <begin position="377"/>
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            <begin position="262"/>
            <end position="303"/>
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            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="449" mass="50507" checksum="8D0673C019C2A59D" modified="2015-05-27" version="1">MADIFNKHIKKATSRTKEKLLEGIGKAKATQDEIFDSHASNLSKQSKTCERLNKDIKAYSSALRVLCQAERALHDTIRETYESEWPDREHLAAILDNTDIQTNELEKALCEDLPQSVSTYVSQFADLKKKVDKRGRKLVDYDHAKHSYNSAKASSKKGETDPKVAKAFSELKQAELLYKEINNELLEVLPATYDSRITFYVDTLQALFNAQSVYQTECSKLNKQIIIQLDRLGESMDFLRVPRTEPHPGTPTESVADVYGVPEIYPSPAPAPAPPPATPSSLVDSCSGQTITTNPFEEDDAVETLENKIYPKLAVARRGESEKRKTTQMGNMKDKTAQQIKTNPFEDDTDDEQHTSVSIDALSTDHTLEGVTKEARKVLYLVRSTHEYKALDTDELTFGPGEEIKYLQKINAQVLETKPKDQVDEGWQLGEKADGTRGVFPENFTKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVM6</accession>
    <name>A0A0D8XVM6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_06075</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716291">
        <property type="protein sequence ID" value="KJH47829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVM6"/>
    <dbReference type="STRING" id="29172.A0A0D8XVM6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022272430" evidence="15">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="264"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH47829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="467" mass="53490" checksum="D8D0518D6C3D70A6" modified="2015-05-27" version="1">MLTRQLFVIAVAVAMFAMSQANRDANRLFEDLLADYNKLVRPVDNNSDTLVVRFKLKLSQLLDVHEKNQIMTTNVWLQHSWTDHKLRWNPDDYGGVDVLYVPSDTIWLPDIVLYNNADGNYQVTIMTKAKLSYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLIHKDEHLQEEAVNMVEGVDGSIEESVWIVHEGIDLSDYYPSVEWDILKVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCILILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTLSVVVTVITLNVHYRSPTTHNMPKCVRRFFIDILPKYLLMKRPPHPGHKQKRGSRTTFSTPNYNSQFPTVPDQNMVHLSPTFRTSFAAGSLEETSYSSFRRDVSPVMSAVESVAYIADHLKNEDDDKQVSEFGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWI3</accession>
    <name>A0A0D8XWI3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716253">
        <property type="protein sequence ID" value="KJH48865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWI3"/>
    <dbReference type="STRING" id="29172.A0A0D8XWI3"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46339">
        <property type="entry name" value="PROTEIN CBG15282-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335974" evidence="1">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26114" checksum="B910502EBD46C92B" modified="2015-05-27" version="1">MFTGMICLLILLPLILAENDCLLGRDSGDSCDQPAGQRFYFDLRTKKCQPFYYKNYPEVKKKIVKAENQKSTRESDDLKLDNRWPAKVIKLFVTPVLQRDHEGCGGNQNRFNTSDVCMKTCANTKSSTATAIQALCKSGAYSAGATSLIQPLSCSECPKGYECENEICCPKKEYLCNLQYDAGKFGDRGSHKPRYFYSKSFKNCMLFTFYGRDGNANNFETYNECKAMCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXA4</accession>
    <name>A0A0D8XXA4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="KN716267">
        <property type="protein sequence ID" value="KJH48452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXA4"/>
    <dbReference type="STRING" id="29172.A0A0D8XXA4"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF210">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-13 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="238" mass="27416" checksum="FE9525577C491471" modified="2015-05-27" version="1">MAEEEIQLSCFTSEISTAIQKVWKDPAVQKLYERRSEINLNDSSKYFLENLSNINRLDFVPTPRDLIMSYVPTVGVQNVVFSAGNRVFQLFDIGGLRIDRRKWATMYDGIDAIFFCIAISEYDQVMVEDPETNRLQDSLSLLEKISNEPKFKNTPLFLFLNEIDVFREKLPLIPLENYLSEYKGRSVQEALDFIESLARQSLAGRDQAVIHIYRTCMIDTEQMSKILESAFQTILSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXE8</accession>
    <name>A0A0D8XXE8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_05484</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KN716268">
        <property type="protein sequence ID" value="KJH48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXE8"/>
    <dbReference type="STRING" id="29172.A0A0D8XXE8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="53"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="255"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="510" mass="55266" checksum="08138F8296DB470D" modified="2015-05-27" version="1">MRPHGSVALTTTSGSAPSLLINIYKSIINFLISSFISEGSRAITNMDRVNKAVEEACRCLKLSDDQLKKVMQALKTGMEQGLKKGTPPGVGLKMIPSYVRATPNGTETGDFLALDLGGTNFRVLLIRLKGSEAEMKGKIYEIPVSIQRGTGEKLFDHIAECIALFTTEQFGSNKRKLPLGFTFSFPLKQDGLTRAKLIQWTKGFNASGCVGEDVVQLLRKACKKRADIDIDVVAVLNDTVGTLMACAFKENTCHIGVIVGTGTNACYLEKLEKVQKMKGEWENDGLPDEIIINMEWGGFGDDGAISFIYNEYDSVVDKLSINPGKQIFEKMISGMYMGELVRIVVEGLAKKGVMFNGSTAGISKQGCFTTAHVSTVEAEAATDGRANSYPKTREILRGIGINSISDDDCMHVAYICAAVSSRAAYLCAAAIAQVLNHIKRPFVTVGVDGSVYRFHPTFQHLLDQKISALVDNQIKYQLMLSKDGSGVGAAVVAAVATRIHKSQSGTDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXF3</accession>
    <name>A0A0D8XXF3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716323">
        <property type="protein sequence ID" value="KJH47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXF3"/>
    <dbReference type="STRING" id="29172.A0A0D8XXF3"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001356">
        <property type="entry name" value="ADP ribosylation factor like GTPase 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="204" mass="23669" checksum="B8B13E4036147B11" modified="2015-05-27" version="1">MFAMINRVLEWFRSLFWKEEMELTLVGLQNSGKTTFVNVIASGQFTEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVNAIVFMVDAADEDKLEASRNELMQLLDKAQLDAIPVLVLGNKKDLPGSLDERQLIERIGTLNWSKQLLSMLRVNFFRNLSAIQNREICCYSISCKEKENIDITLQWLIQHSKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY44</accession>
    <name>A0A0D8XY44_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716229">
        <property type="protein sequence ID" value="KJH49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY44"/>
    <dbReference type="STRING" id="29172.A0A0D8XY44"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF117">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="27191" checksum="0CDFF273306BD9BC" modified="2015-05-27" version="1">MSEAHQISMVQQADPSFLPHSKMLLMEEILRVYRLVNPACTVPQSLSSTNIQKDGKVSSPTALDAQELSQTLVENMNRALNCITNAKQSSINNGMAMTDEAHQHAFTLNEKVFIPRSHGRRIKGSKCNFIGRIIGPAGMSVKQLESDTGCHILIRGRGSVKDPRKEQRLRGQPGWDHLEEPLHVLVTAVDHNHTVCQQKLRQGVESVRHLLTPAHDDYKRCQLMQLAIINGTYRQAQESSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYL1</accession>
    <name>A0A0D8XYL1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LUC7 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYL1"/>
    <dbReference type="STRING" id="29172.A0A0D8XYL1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36674" checksum="929C561ACF7EA5D1" modified="2015-05-27" version="1">MTDVMRDMIAQLMGSQKEGEEGRDLQPYNHPSVCRAYLIGCCPYELVPDSRLQGLVSCRKTHEPAHKADFLKAQKERDHYYDVDAFDILENAIRIVDNEISRIKDKLDREAREQTDNAEAVKTQRISELSEQIGKAVTEMEELGNMGKVEESMKLSKTVEDLRARKSELEFRLAGPGSNAARLRVCEDCGAQLNIMDHESRIADHFGGKMHLGMVECREKYAEMKETIEERRRERRERGLDSGSRRSPPRRERERDDRDKWDSHHSRGSSRRRSRSRSNDRERDRRRDRDRDDRRSGSGRDRDRDRDRRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYN7</accession>
    <name>A0A0D8XYN7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716224">
        <property type="protein sequence ID" value="KJH49743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYN7"/>
    <dbReference type="STRING" id="29172.A0A0D8XYN7"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="26804" checksum="E6305A308D839321" modified="2015-05-27" version="1">MENDSPGIMLRKKRCLFGKPDRNEVENWLSETTKKQLKNSRVKWSYDFELDKPVCGDVEYERLPIDKAGFSTHYVPSVYKPLTVRKKKVKKAEFDPNIPSVSTKQENDINSSIHRPLTRSFVRQQSGEDYRCRRSLKQAKLTNYLRVRKRRSVESRSPKQHVASLKSIKSNFPSSPFRFVDDVDGDGAIPSSNSLRSFSSSPSKSPRKRPAHKIPQEFSSQVSKFHSQIAADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYY9</accession>
    <name>A0A0D8XYY9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Miro-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYY9"/>
    <dbReference type="STRING" id="29172.A0A0D8XYY9"/>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22651" checksum="54E72E9AB7101A32" modified="2015-05-27" version="1">MISVLRRKLGGEKDDCVPSSIPSGIQRVDKELQKRFSKGIQYNMKIVIRGDRNVGKSCLLRRLQGQPFLEDYIPTEEIQVASVDWNYKTTDDIVKVDVWDIVDLSPKRRQWDEAACDARFVNVYKGAHGVILIFDITKLWTWDYVQSEIKTVPSHIPVRTFWSIEFLVRNSTMNTIFFSFSFIVNSRFSRFYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ56</accession>
    <name>A0A0D8XZ56_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_06295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Tyagi R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="15"/>
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        </location>
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            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="29073" checksum="6FC9F5CCDE40290B" modified="2015-05-27" version="1">METRSKFACLYIDDDSDEGFTTDGKKSSKISDCQRGDKHVKNSGKLIVHAVEKRPKTKKTNKGKIVDKATGLIVQGADEQYISEQKYREDLKQAMERSTHANSRSSVVQPEATMFSDLENKESVDDKLSPLDKVLRQNGEELQRLDSLNIDGEENSDPVIVELYKRKLNEAVDQMIVAKEEKQSAQAELEKYKTRYKKLVELFRDAEVADKAKLITELEKSRNSEAELASQLIVTQKELEQYKSKLRALGALTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y074</accession>
    <name>A0A0D8Y074_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716284">
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        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJH48001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="488" mass="54872" checksum="D8CF6DD01C652F05" modified="2015-05-27" version="1">MCGVNECKFDICEEKCVDLPFAYRCECEPPKMTDPKNPTRCIMGNQCMTSNCSQFCIEKGNDNYECTCATGYLLESDGHGCKLKSKLVLPMFLSVTSDGIRMGSLRGSYQMLSINSTTGRVLAYSAKLSSIYWIDGNETVGRTFTNGTNMLLQDVSVFCPDSLAVDELSGNIYWTTKSRNAIMMSDSDSRYIKTLYRRGPSVLPYALAIDSTHRLIFWSDIGKKASVNRMSIIEDDGGVDIILDTSLIKPTALAVDPFAKRIYWIDEALDYIGFCNYDGTNRHVLARKIGRGLQAIDVFADYVYFSDYSKGTVERMHKIHGSSMRTVVFSGLSHPRGIQIIHPEKRPKKEAYNPCQDDSTCTQLCVPSDNTKIYQCLCRDGMRYDDGKCVNISQISVLSDDSVMDYVSIRNFVLSIIITCAVVMFFFHKNRSYILSSITMENNLWQVEGQERFPLSRVTRDGGVENPVFEPNEDTPMDPTSTNTELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y099</accession>
    <name>A0A0D8Y099_DICVI</name>
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        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716234">
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        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="440" mass="49752" checksum="1E4C211BC3B5945F" modified="2015-05-27" version="1">MADCAGPLRPADSWSTTEVRSVTHSHVWTIKGFSQCECRYLETSAKIRDLTQVTSMSLPPPTSTSNLSTLEPPMLTFRIRLHPQGNKESNKDFSFFQCFSNQTNVQFKAKFKFTVFNSRNEEIPTTVYTGTQQLHGYFEYIRRDLLISHVHPSDELQLVLNMTVTFDTVTRTSQAPKTLGPPEPKPAEVTKDLESIFKDSKLSDFVIVVGDREIPVHKVVLSARSPVFAAMLEPHTEEAKTNRVVLEDMDYEVMHELLMYMYSGRSPNIQQMGLELLAAADRFQLPGLKEMADHVLRSGLIVDTACKFLVYADMYNSSDLKTEAVKFIAQNINSVIQTDTWAELTRDHGCLVTEIVAHMSSERKPCIGSVTNNANSIHAVSLNSRQLFSSNICCAFVFWITNLVFDVVRLSTYPCKNPSVSNKLAYFMFEPMNAMFKQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Q8</accession>
    <name>A0A0D8Y0Q8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
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    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716205">
        <property type="protein sequence ID" value="KJH50458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sm"/>
    </dbReference>
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        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH50458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13052" checksum="622D3C43EC6F13E3" modified="2015-05-27" version="1">MVKPRAEMTQEELAAKEQEEFNVGPLSILNNSVKNNAQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEQPKTGKGKKKAKAVPKDRFISKMFLRGDSVILVLKNPLATTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1H4</accession>
    <name>A0A0D8Y1H4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="4 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_03813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4 11"/>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1H4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1H4"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH50012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="471" mass="54227" checksum="4D6F06E8DA49D8A0" modified="2015-05-27" version="1">MSRCQRSDSMSSPLSPDLIAYLRESMKELKFDPPYVFVIFGASGDLAKKKIYPTLWWLFRDSLLPINTTVVGYARSDITMEILRDSFEKACKVRDSERKKFSDFITRCTYMKGCYDTPEGFRQLKLFIDEVQCKNNDQPVNRLYYLALPPTVFESVTYRLSAHCMDNGDSWTRVIIEKPFGHDLQSSNKLSTHLSKLFKEEQLYRIDHYLGKEMVQNLMVLRFGNRFLGPSWNRDNIASVTISFKENFGTKGRAGYFDTAGIIRDVMQNHLMQILTLVAMEKPSSLNAEDIRDEKVKVLKAIKPVESKNVVLGQYVANPECARGLCIAYLKSIMIDPEALMGYKDDKDVSPNSITPTYALAVLYVHNERWEGVPFFLRCGKALNENKAEVRVQFKEVNGDIYPPGELKRSEFVMRVQPNEAVYLKLMTKKPGMGFGVEESELDLSYNARYKERDAHRTSRISKLLLFTNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1V2</accession>
    <name>A0A0D8Y1V2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1V2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1V2"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF25">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="88"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28821" checksum="2F0B09798C0709BD" modified="2015-05-27" version="1">MIPIQMALFITETKHLGIRVIGGKRMPSGELGAFVSAVNQAKYNQILGEVKEDISPDQAPPVPMHRRNGRDSIHFQASNPNRIYDNNSFGYLQIAISYDRNTSRLIVRIMAARELKMRDPVKRVAPNPFVKIYLLPVRKVSNKRRTRFVPCSTNPEWNQIVEYHVSPAMLSSLYLEFSVWDYDRLTENTSLGQVIVTLSDRSIISGQPFWLALQDLTNSRAIRSNLNAPIDDERLQVYNYNSALLDVGYPAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y239</accession>
    <name>A0A0D8Y239_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxidoreductase, 2OG-Fe(II) oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_03651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Lumenal side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y239"/>
    <dbReference type="STRING" id="29172.A0A0D8Y239"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001006">
        <property type="entry name" value="Procol_lys_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01325">
        <property type="entry name" value="LYS_HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="11">
        <location>
            <begin position="227"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH50212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="318" mass="37538" checksum="DF27E797BF8B8D44" modified="2015-05-27" version="1">MFTNFWGAVASNGYYARSEDYLAIVQRKRIGIWNVPFLTSAILINKEKMKEMKTPYYYDKTLDVDMSFCKWARDKGHFMYADNEEYFGFLVVSDDYGDIVHSGKIHPELWEIFENRELWESRYVHPDYHKLLEEGVEVKQACPDVYDYPLVSERFCKEIIEEMEHYGKWSDGSNKDERLAGGYENVPTRDIHMNQIGFDRHWLFFMDEYVRPMQEKVFIGYYHKPIESNMMFVVRYRPDEQASLRPHHDASTFSIDIALNKRGVDFEGGGVRYTRYNCTVLADQVGYAMMFPGRLTHLHEGLPTTKGTRYILVSFINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2F3</accession>
    <name>A0A0D8Y2F3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2F3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2F3"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000145">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000155">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF93">
        <property type="entry name" value="GALECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 5" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="151"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <source>
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        <source>
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        <source>
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    <sequence length="107" mass="11799" checksum="9C041C3DD9006ADF" modified="2015-05-27" version="1">MPNFSSTEDIPLADDDDNCSIIGGNGIPRPAQPLPREEPSEDPEEKARLISQVLELQNTLDDLSQRVDAVKEESLKLRSENQVLGQYIQNLMASSSVFQSSNTGIKQ</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="29"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="92" mass="10687" checksum="EFFB1275F479772D" modified="2015-05-27" version="1">MADEQMTSENEVMNNTSYHDYHQQQQRGISLSRAGLQNEPSVCVMRDDIQLPLSTLQQNLIQGNTLVRNFFNVLKEKDCLFEKPHGQEFEKT</sequence>
</entry>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="497" mass="56822" checksum="299542DEFC412BD2" modified="2015-05-27" version="1">MEASVSCLPPIAWACAIGQAQLVHKLRATAADVNAVDSEGRTPLMIALLANKDTAVAALCGDDSITMKKDTRNKTTKSKRTRLVLGSLNSRKRKASDSEGEITEREGCSSGLNEESKLESNGDLEPTEKFSKRIRICNKELDLMKCDRNDRNIMHYMVEPLQWENVRLLERLHKEAPSKIKQLLQQRNKDGDTPFDIAINTKQRKMIATMKRILSGSTSSKKNIVLNGCYSHHMPFRVMVLDLPDVSDLICKHNIDEDSKLFLKFWQAENEVINVTSASKPSALSGYRDTAELVYCTTTHQYMTAVLNKTELSYGRFGFHNFYRIELMKRRDVDLWILFTNWGRIGQGRGEYQITPFNNFDAAVKEFKSLWRSKTGRDWEPFDQFQVVPKKYRLVKNTKRINNMREISVPWTEITEKNLVRKTIQDISNPQKLKNYAREVNCSIICPLGHITESAIIKANSVLDECEANTKKLEKILLKEGSNDADILEVQYLKSPY</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <source>
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        <source>
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    <sequence length="142" mass="16271" checksum="191660A6FD541BC1" modified="2015-05-27" version="1">MGLRSTDTNENMESFALLSILSLATKLSKKTWQHPQQNVWFQNRRTKWRKKEAADNALGKRQEDLKSPCEQIQALKNMPCRTKLVLDFAINYDKGSSTMYRELSSMGGGGAMLKYRSSLIKVDHIPQTHLTIGSYFRKTLQS</sequence>
</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="term" value="P:neurotransmitter transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <begin position="32"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH51738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12200" checksum="393AFFF682A00296" modified="2015-05-27" version="1">MATFSTRYSRLRDNVEEEPNSSAFDEIIMKQEQIIRDQDEDLELVGRSVNTLKHMSTKIGDELNEQAVMLDDLGNEMDTVDSKLNNVMKKIAKLTHMDDGKCTCSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5K7</accession>
    <name>A0A0D8Y5K7_DICVI</name>
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        <name evidence="2" type="ORF">DICVIV_02538</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716187">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="31124" checksum="3C484424DC4C519F" modified="2015-05-27" version="1">MSIGTKFFSSPISFSRSIFPSRLFSLDNEKSYCDCLSNDNYTAATDRYASYGIAVDVLAIDFWIVKILRDTVGHFTSGNKETSIKIYIRFKLRNQLDELFFPRPSRRQFDSLAFATLFWNDSLTSGHISYTSRRCSAYHYDFLNAYFERFKQFSMMRMFLSIENRTWKYEKENQEAFDMAFISTVGDATSLAMSDCTTYNCRVQYVDDSDPFASTSNAFLEPMRPVTFSFRIHETIADQLPEVIRTLRAPHKNMDEDFYYSIKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5P6</accession>
    <name>A0A0D8Y5P6_DICVI</name>
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        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">DICVIV_02254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716181">
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="398" mass="45845" checksum="6950A0DFA51C27F6" modified="2015-05-27" version="1">MPPTVEAEFDANVIEQVRTQVSDILHPRYDTYFNILRWLKSYEFNVSKTVYNLRKHLKFRKERHLDEDARGLQRSAVAAEYAPISIVGPNRKGGDRLIVVDQCGKVDIGGLMKSIQPTEYLHQLYRNFEKILSLMMEMEAKTGVQCYVYYIFDLDGLSFDPTLLGVINGPFRVSWQLIGQHYREVIGRFITVNTPSYINVLWSALSPFVPENEKSRIALTGKNWKEEILEVADAECLPEKYGGKLCDDKIMRNPKPVPKGIYWRPRTGYPSLAAMHRISIPAAKTRTLIYHVQANTDLLFYSQNDSDITFSFYYSENENIPEDECEVLVPPVQKCGLPAMDLYDMRAERTGYYYLKLANDAAWLFPTTYKLIVHDKSGGEIKAINQDEKWIKHGVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y603</accession>
    <name>A0A0D8Y603_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716218">
        <property type="protein sequence ID" value="KJH50001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y603"/>
    <dbReference type="STRING" id="29172.A0A0D8Y603"/>
    <dbReference type="OrthoDB" id="5984396at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46292:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 102A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="243" mass="28243" checksum="86EA688610F545F3" modified="2015-05-27" version="1">MEKTMRWWSECTACWREKWSTVRNERNRAREEGQTLRHAYEEAKVKIDVLQSEKRQVELELLKAKSTLHKLAVKNSITQNRVRSLYATLPILQYFEIPEVTIQRIDEGCDAKPESFTEGVQTDDDVSESSEITSSTRSLIGSRSSLAQRERMQLEDRCTELQAQLNSASETISELEEVKRTLTEEISEMKRCYNDNIENSRAIDNTEINQLRDELAEARAELRRLYEENAALRMTRDSTTGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6S6</accession>
    <name>A0A0D8Y6S6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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        <property type="protein sequence ID" value="KJH52067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D8Y784"/>
    <dbReference type="STRING" id="29172.A0A0D8Y784"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46587:SF7">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="53"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="323" mass="37551" checksum="4B758513F3E54875" modified="2015-05-27" version="1">MYLPHNYFLDGGTKHSIRTLQPRRDLIGCRRMKTHQQSSSPTEQISPNPVKDYQLLLIERLTEIDQRIRKKKFELVRSKKEAMNLAEVVRAGFFQNDGSDKLMIVLAKDISNVTQTDLLMMLEWVRTLPCFPSLAVDDKRFAIHHLVLEHGFFTASTNMEDVWLISNGTCMPRNVEVLPEECRSAISPDRRWRQEKLYKQMTDTCIDEVATPLRHLKLLPQELVVLKIIMLFNCGNHTESSEISDESRKTVLAYRDQVITALFQYYQHIHYKNYPERFGNLILMISGVISAASAMLESYQVMRLFKIVPFDNISQELLFNHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7K8</accession>
    <name>A0A0D8Y7K8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alkylated DNA repair protein AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7K8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7K8"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidative RNA demethylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkb"/>
    </dbReference>
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        <property type="entry name" value="AlkB-like"/>
    </dbReference>
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        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30310" checksum="9CA6D3F3952A20EF" modified="2015-05-27" version="1">MSREQVLSNCVGTTELDQLGLKPLAEWVVVTLKGRPGLYILPNLLRDDAVEMWLRRMFVYAEPPNITNLTAHGINFKRDLLKEAGKSLRWATLGVPYDWETKKYPLSGDRLPKELVITKVLSLGTMYADAAIVNYYPPKSTLSPHVDRYASFKFQTSRKNLVLFYSQLFSSQYLWLRSERTDAPLISLSLGQSAVYLSGGVSLDDDIVPLWLRSGDVLVMHGTQRFVYHAIAAICSDRRFTMEDPELGQFINSSRVNITIRQVNCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y829</accession>
    <name>A0A0D8Y829_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y829"/>
    <dbReference type="STRING" id="29172.A0A0D8Y829"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Tudor-knot" evidence="8">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="145"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39510" checksum="A86213AFEAA8AE78" modified="2015-05-27" version="1">MDQRHDDNHCSRIGNKKIMLKHMSYELNDRILCKYGDLYYEGKIVNISTNADGRVFRVHYQGWHKRHDVDIPEQQSKQLFLPYTAENLARTKTELENARLERKRKSTCKNASAANANTSTNASSASPVVTPRRDVNIIVQYYGCLPQSLRDILEKDRDAVIHRRLLAKLPAMYTIDVIIYEFLNSLRIDVTKKGDKLIVFFDDDVSSSRISDLIRSCQMITDYFNLMLGKMLLYPPERDQYQSELLRLRLSNLNDAEDSKERPHLGSTQLPDNSIPVRHTSVYGLPHLLRFFNSLTEKSEGMSVDSGPLLALKVITSELVDFLNENREKYFSVRRDYEPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y862</accession>
    <name>A0A0D8Y862_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="6"/>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y862"/>
    <dbReference type="STRING" id="29172.A0A0D8Y862"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26419" checksum="EBCDF0C60A415A55" modified="2015-05-27" version="1">MTNIYPGHIPLSIASRIMLGIGSAAAAIYDPGRGDMVATMGEVTATQLNLERIRQRMESDIIGSRILNEQPRVTNETVDIKYLRTLPDNTFGKEYSKFLDNLKTSPDARPPVKFVQSKELTYIMQRYRETHDFNHVLLQMPTHMLGEVTVKYFEAIQFGLPMCITAGLFGAIRLQKNHRKRFLTHNLPWIVEQAQHSRFFLAVDWENQWEEPVSSLQEKLGVVPIEKYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8B0</accession>
    <name>A0A0D8Y8B0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8B0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8B0"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000036">
        <property type="entry name" value="Protein CBG02294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="110" mass="12650" checksum="D55F940E307A239C" modified="2015-05-27" version="1">MANITNLNKPKDAFEQLEDEHGARQGFCHIRIQQRTGRKTITTVQGVGTEYDLKRIVRFLKKKYSCNGTIVEHPEYGEVMQLSGDQRQQIKDFLVNVGIVKEENCKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8V0</accession>
    <name>A0A0D8Y8V0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Myofibril</location>
            <location evidence="8">Sarcomere</location>
            <location evidence="8">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716193">
        <property type="protein sequence ID" value="KJH51006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8V0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8V0"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09339">
        <property type="entry name" value="LIM4_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    <sequence length="412" mass="47560" checksum="22B9CC73FF6E316E" modified="2015-05-27" version="1">MVMEVDASNRLAKYCYDMLTQVDSKASLLSEKLVSQKRRVMMKDCIRIIYYCHVQRSSGCRYEMSVCVPYNPEEKLRIDDFNVHTCNTEDTKLRRRAKPQVEDFDKPIEKRKAQPSGVPSGKDDFGTAPYLFGDSVTNFLNGLNDHLDADNDFEAEQSDFGYSPELGVVQNDNLVKFISELGHDTKSMENVITSRPGPSTVWATVEVDVVDFSKRPDPPFTHVFHARDEVASQFSYASPMIGDRAELVAEELLRLFYLFGSSRSAKLDAIYRGTVLEKLVSERFPTLNLIFQAENRNQQGTMAPRRQESIIRERIYAWLLENDKMHWHRHLTEIKYMHNSEWIDELGGTPMEMFFGRMRSPEIPRKRKADVTIHDDNKHNRAQINKSNGTTSQLKNVSRLYFDSNEVKVDET</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="398" mass="44089" checksum="42ACA613AC66A111" modified="2015-05-27" version="1">MCRSNAVEMSDLDRQRPNGRGMYVSKQFQPKKYKDIGQEWCRTEPSSQSVFIPFKSNSISRSTTPLAPISEQNSTTGSPQRSNKSHPFEYHNETASYNNLCQVQDLPKSHSTPKVAHHPQIRSESAIPMSREQKLTWGRLPPSASYRSSSAMAQPIRPLSRQSDVGIGGGHCSHYQSYCTLPRPEEVDGGTLNDMHSNLHAFHSNTIPKVVSRMPPTTTMVPTIPSMIKSDSMHAPSLIAPSNPVQSTPPILLKQKEVISWNTLSLLCSMQVLSSLTIFGIGIGRMLQGAKWGIGIELGYAFTVLTVGLVGICAVRQRSNAAATFVFCLNAFCFILAIPPFVIGLFPAIPWAFAEATPSLWTNAREPLELDFGLSLIVLIQVRYYIDYEMNCYSIKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9S1</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="53"/>
            <end position="263"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="269" mass="30206" checksum="1E39FE5AC4F4E99F" modified="2015-05-27" version="1">MSNIMKIIFVLFSVMEASYCLCGRLRLYEQVVLRKHCGQHLFSQTSTSRSKRTIGGVNAREGEYPWNVAIFGEGRYCSGTLISYRHVLTSAACMTNRILTETSWKVSLYSYTVIPTDDIRVYTGAHIMFVRPNNDGSYGHRIHNVTIHEQYMCDTRYRNLAAFEISPQIDSDEATPICMPKEDEKIKTDEVMTATGFADSTGPLYNLQAVNITIGEVDNINDELIAYRSNHSVCQGDSGGPLFKNTGKQYTLFGITSRPIGCSIRYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA79</accession>
    <name>A0A0D8YA79_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00142</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA79"/>
    <dbReference type="OrthoDB" id="5850460at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="187" mass="21497" checksum="FAF93409C650A1F7" modified="2015-05-27" version="1">MANVRLLSFSYVYSIIESDKPGAEIPAEIERAIQQNKLADGVTAPTPVPQADRKVGSNESSKSIPLRDIERVLPIYLRVYFKEDGKTKRALIEYEVKNNETLLDMLSVMLRKLKTLKGKTEAKGRMYYTQRKFRNPAELDFKNYGKIVIEDLAEMGKSMFFVFDMAGRLDRVSTDDHMLQWVVPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAZ0</accession>
    <name>A0A0D8YAZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAP-Gly domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAZ0"/>
    <dbReference type="STRING" id="29172.A0A0D8YAZ0"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="233" mass="25447" checksum="4717FFF153BCEFB9" modified="2015-05-27" version="1">MRLIETNNPTAVVTMQDVGSFVSVSGVGKGILHYVGEVHGKNGLYCGIELDTPTGKHNGTYQGVVYFVCRPRHGIFAPLYRVELDEIDDVPMMTASQTTKVHEYSNLSWGDSSDAMVCSNATFVIPPGRSHFEDSEECDLMSIPAPKSILNINREQFKHSEESILGTSVVLDESRVGVENLPVTPLVEAPQWQPSLGSFAQPPSIIETTASPITESRVLSDHTPKECALFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAZ2</accession>
    <name>A0A0D8YAZ2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8YAZ2"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Held out wings, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BBP-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
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        <property type="entry name" value="RNA-BINDING PROTEIN ASD-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="81"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="21206" checksum="AD71A79C052A8A34" modified="2015-05-27" version="1">MNCVNLYDFVSGSNITTSQQYSVEYLSQLLKDKKQLSAFPNVFHHLERLADEEISKVRVALFQFEFTKEEMSLPEPEGDVQVTTEKVFVPAKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEELNRGKPNWEHLSEDLHVLIQCEDTPNRARVKLARAVDEVKKLLVPAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBM7</accession>
    <name>A0A0D8YBM7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBM7"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15347" checksum="FA0C82A6D953AA47" modified="2015-05-27" version="1">MSTLNSVGEQTDDRIFAGREIQTKLFGLISYEYVLIFVGGVNFTSTVLHAYYTRYGTYEPHILVVVKVIWFVLALIGVLRKVSVCMAACMVCNLINGVIYCITVFAAHNFREFLIRLCREENDCYSNRVEFLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDV2</accession>
    <name>A0A0D8YDV2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDV2"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="30642" checksum="AE8D718507EDC3C7" modified="2015-05-27" version="1">MHDCMLRARSHVKFVANFDLDDFPVAMNANLPEVLKKIDDENKDIAEIIVDWKLTKQMIQWDSISTPSDIRFMLFASKLVADKSIRTDYLISKKMFIRPERVALFDMHNVYRNELIPGKAIQYGFVYHSSQRLFILHMRRFHRNLINDRTLYNSSTNTRFLIALNRKMTMNFRKRIQWDEFSAHKMSPWATEAREILRNLEQCRREAFGTILTDDNKICQQSSGGCEAMLTTRSNFIRARMSWIDLAHTAYFNNYTIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5S4</accession>
    <name>A0A0D8X5S4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719972">
        <property type="protein sequence ID" value="KJH39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5S4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9779" checksum="D0F488A6D5340B92" modified="2015-05-27" version="1">MLSFSDPITEKDLPAYDPDDELEETQQDACYRQSLDDLFNNLFNNDNLPDSDEQGCKAFQTIITKFHRILKNTIIFADQLLYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5T5</accession>
    <name>A0A0D8X5T5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719455">
        <property type="protein sequence ID" value="KJH39890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X5T5"/>
    <dbReference type="STRING" id="29172.A0A0D8X5T5"/>
    <dbReference type="OrthoDB" id="5850742at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15341" checksum="7D5015DFBBEA92BF" modified="2015-05-27" version="1" fragment="single">MDIDLRERIQNNITEARLIKSEPYITAREYELALRILIRNHQATYYRTYSQKLLRNLNVYQDDYGILRCKGRLSNAYIPIEAKRPILIIPNTPLAEQIVKEGHLPYHCSISQTIATVRKQFWIPRLRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X685</accession>
    <name>A0A0D8X685_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN718483">
        <property type="protein sequence ID" value="KJH40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X685"/>
    <dbReference type="STRING" id="29172.A0A0D8X685"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="16075" checksum="943FCF07AFF695FB" modified="2015-05-27" version="1" fragment="single">TELFLKYKVDPNAKDNQDLNPLSLNVSKEIDYHKYSNLSPTHDVGIYRDVYCKNIGFEFMHISSYEERMWLQEKIENQTYTLNSQDKKEILRHLIESETFEQFLHMKFPGYKRFSIEGGESAIVAIERIINDSVAF</sequence>
</entry>
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    <accession>A0A0D8X6R7</accession>
    <name>A0A0D8X6R7_DICVI</name>
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        <name evidence="1" type="ORF">DICVIV_13834</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717520">
        <property type="protein sequence ID" value="KJH40225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6R7"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="10432" checksum="AC2FCCC09CEBCCFE" modified="2015-05-27" version="1">MNDHTTLYRKNDARRFSYHANKIVPYKTKIETAHIAKMKKCRNCIDVLVHSVPYDMEILENNLYRQDQSFYFLPRRCDIAGPDHEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6X5</accession>
    <name>A0A0D8X6X5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717456">
        <property type="protein sequence ID" value="KJH40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X6X5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="20489" checksum="650A14D962899E26" modified="2015-05-27" version="1">MHLYSTWNPEKRPAAAPSDFYDKFSLISMDSNAIAPGHTTNIIMANWQRSMWQDVMNRALRSLSSGPFSSNFIRASIKLWLTLYLYIAFIEAMFFNNEFLVLRKTDKIVVRLRSQPFWSGNTDNPVLSNMQNKEENCYIIGDTVTNLCLMMAGGGCMTGDVPQKFKNLVGTLTVMLLGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7T5</accession>
    <name>A0A0D8X7T5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722010">
        <property type="protein sequence ID" value="KJH39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7T5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7663" checksum="174553869589C229" modified="2015-05-27" version="1">MLSFSDPITEKDLPAYDPDDELEETQQDACYRQSLDDLFNNLFNNDNLPDSDEQGCKAFQSIITKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8A5</accession>
    <name>A0A0D8X8A5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718496">
        <property type="protein sequence ID" value="KJH40017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X8A5"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="66" mass="7448" checksum="D64B6734590B82B8" modified="2015-05-27" version="1" fragment="single">VVGYALLGAVIFQAVERPHEEQIQSSVTAARGRAVDVVWNATFRVNRLNQDQWKSAVYKEVRLHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8T2</accession>
    <name>A0A0D8X8T2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KN716950">
        <property type="protein sequence ID" value="KJH40963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X8T2"/>
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    </dbReference>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH40963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="645" mass="73228" checksum="CD52C1EF6D5824C6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X990</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716887">
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    </dbReference>
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    </dbReference>
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            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="378" mass="43635" checksum="C324A64EC22E6C0E" modified="2015-05-27" version="1">MFPALLCLIILFGKCLAKDPIGQNVIVLLIDGYGARMQHLISHGVQAEYLRSSFPTQSWPNWLSIATAKKEVRAISAVIFELHVIDWYLTIVFPGLYTESHGMTADYMWDKNSKLSFERGKGANDSEDIWWEDLPAPLWYTAGKSGVDVHCYWFAHCHRAYHDMVVKVPLKRWTDLNSPEQTDKLSELFPEIVNRIIKYQAYKQQMFLMRYAGVDNALKQFGAHSDEVEQAVARIDLYIHELQQKLEEYDLFTSTNLIVLSDHGLAQIEEEEQFYLEECLSDYSKVVKVVNIHSMLMVFTEPQDEGHVHFELRVCDQWAPMGDYEDTDALLVKAYKLSEIPERLHWTNSRFMSGVVLLTKPGTSIITVFSFTITIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41213.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="524" mass="60990" checksum="B9BDCFB2DF489B13" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAZ1</accession>
    <name>A0A0D8XAZ1_DICVI</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717008">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
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        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="343"/>
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        </location>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41462" checksum="B26CEEC535D5D048" modified="2015-05-27" version="1">MLGGQLKNLEHLNLHLNNSPCTTVHCKAQRNKATMSVDAINALDDSGQRIMKIQVPKSTSSDEFLENEELSTDSDSEMSNDGDSSSSELSDKCLDQVKQNNPNVENGLQKFDHRNTETSFPMSARFLRSSLAPGMTGNRVPAGNAVARFRGPVGLIAYQGKVPSAPTLAVRKNEKILLQSFTLKRFLMSVTSLYFVLDVPYVFFYDYAVDNLQIEQTSAAWLTSIIGVANLLSTWICGVISDAGCVKLRLFTVYGVAMCGLAACMWFVILAHNTLGMALICAFFGFFISSNYVLQSVMLTSMWEDMRNFQSSYALTSFCEGIATLFGPPLIGYIRDCTGSYKLVFIVSGFLCLFSAILSFVVQTIINGRTEKPRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBJ9</accession>
    <name>A0A0D8XBJ9_DICVI</name>
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        <submittedName>
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    </protein>
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        <name evidence="3" type="ORF">DICVIV_13006</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="547" mass="62188" checksum="692CB27581F338E7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCB4</accession>
    <name>A0A0D8XCB4_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="23685" checksum="8F691D0395B3CC51" modified="2015-05-27" version="1">MQWTSNEELYHLRFISNKQKKQIDELNREKSMVKEQMMLLRQQHIENTSDARVVVMSQNRFLNSEIIRLNQQCCELQEEVSRLNEELRKAQDIINQSRREYVFALQSAIRIPLHDNNTLDVMHVKLLGGDMHKHRICQLMHEARNNQPYLPTLQSLLTGVYVDIFGFRHKYYDEGLAIHYMAMQLHEYYQRRLELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCK7</accession>
    <name>A0A0D8XCK7_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Forkhead box protein fkh-2</fullName>
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        <alternativeName>
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        </alternativeName>
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    <gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transcription factor. Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716810">
        <property type="protein sequence ID" value="KJH41507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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        <location>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077297"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="290" mass="33250" checksum="B702A5F8541BD061" modified="2015-05-27" version="1">MVAPYSDRLPDLNWFLNIAASPGSASLTSPRKQSDKIDYHAMNMKPPLSYAQLIMDAMAERKVKKITLSEIYEYVSRRYAYYRSSKGPWKNSIRHNLSCNQLFKRIPRQNGEKGKGSYWTINDVSTNTHNSNKKTKTKLNELENFAAKSTSRVNSAVLQYMDSIQNRHKPIAPQDISLFDEPVSIACEDQLLSNYENNSPAESSVNVDLSDCSLADVFCLSDNHSTTYEENWHNEIPSYDLEGLPSEPFVVHIEEFHCGSIDIDPNTPPQWQDVDQYYDELVRLENEEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD01</accession>
    <name>A0A0D8XD01_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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        <location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    <sequence length="112" mass="11620" checksum="9635B80365350C0D" modified="2015-05-27" version="1">MLLYIAITIFLVVLISLIGCGNKKPASSEPGADSKKESPGKRKRPDPSEGAVDGKSAKSGNAKKKSSEKTKPQAPKQDQPAALPDAGGDDVGYESCPDMTPEELAKVVGAPK</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    <sequence length="112" mass="12513" checksum="410AC715E4C54B09" modified="2015-05-27" version="1">MSKKLQTLQDWSNKHVFTSSIDYWNQESSEMECFPARSKGELSRKDYGTVDERSEGQGESFLPVSDTVDDIAQPITAMQAAWNVTNAIQGMFIVGLPIAVKVINNMLCIIPL</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">HannoverDv2000</strain>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">HannoverDv2000</strain>
        </source>
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        <location>
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="860" mass="96991" checksum="A447401E8754C623" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE76</accession>
    <name>A0A0D8XE76_DICVI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_13329</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717041">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="130" mass="14946" checksum="028DD049977C280D" modified="2015-05-27" version="1">MYRVRSYNGILPLVVGLRPQFLESCVGVSGTAMMCLDSQKPVFVQLYNKETVHGQKRSMPCLVISKKFGSQHFLPFYKPWYAFVDTLKLNYYDYLKLVCLCSCKIKIDQISTKSSNTSIHLARLFSIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEA5</accession>
    <name>A0A0D8XEA5_DICVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DICVIV_13295</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717030">
        <property type="protein sequence ID" value="KJH40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEA5"/>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="16403" checksum="15D88A2564112A76" modified="2015-05-27" version="1">MHFVGCDRQLFSFLPELIEVTKISKQTPGSKLIPLDTEQKSNIKMKIWLLFKVAIWMTSWKLLNAESFNEIELYDVNDPRMLVDCFQCTSRSRLLMIDGHMLFHAGRNKNITFLTSGSGTIFVDQTDISKLPELKVTFVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEE6</accession>
    <name>A0A0D8XEE6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="KN716718">
        <property type="protein sequence ID" value="KJH42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEE6"/>
    <dbReference type="STRING" id="29172.A0A0D8XEE6"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="124"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="404" mass="46055" checksum="EEB29A24D3BD446A" modified="2015-05-27" version="1">MKNTFAHLLKNCLLLYNNIRMSSEKVINVKTINPNVITMQYAVRGPIVIRAVELEKELQKGAKKPFKSVIKANIGDAHAMGQKPITFIRQVLNCVCNPSLMEDGRFPSDVIEHSKTILRGCGGHSAGAYSQSTGIDIIRKHVSEYITKRDGFPCDPENVILSGGASESIRNVLKLFIRRDVSKKTGVMIPIPQYPLYSATVEEFGLGQVGYYLHEEKNWSLEEEELERSYKESLKEYDTKVLCVINPGNPTGQVLTRENIETIIKFAHRHKLFLMADEVYQDNVYAEGAKFHSFKKVINEMGEIYMLTEDVWKKDVLISVGFRMELASFHSVSKGYMGECGMRGGYVEFFNLDPDVYVLFKKMISAKLCSTILGQVSRLFIFYALKYSSIVQWTPYPRDKFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEI7</accession>
    <name>A0A0D8XEI7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716701">
        <property type="protein sequence ID" value="KJH42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEI7"/>
    <dbReference type="STRING" id="29172.A0A0D8XEI7"/>
    <dbReference type="OrthoDB" id="5835933at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="366" mass="42403" checksum="E1B9401189DDEAE2" modified="2015-05-27" version="1">MNGHRRFLMTGIKRGFENKVTYYETKRNCSEIVNGKTHILFLHFGLPRTEFYAKDFLKKSAAIYYQIPKKIEKFLPSGLIVNEKVRTCIEKYGESCRIDELLNSFADRVRICLNTLVPEFKSITCSYAFLFDEPSIEQEILEVARSGCDHIVAAPLYAHFSCAYSGFLLNEIERVLNFYTVPAIVDGKEVHYKRILPNSSNSFHVSALHRWNSHPVVSERSYNSKEYRRSVWSACERVMNGLNDRLLWRLGFYNAWDQWDLPVRESIEVQTKRLAAELPVKSQIAIVPITSLFPDFNTLSVIPSITQLTGKSLVIQPERDNTVLLQGVVEVIKNHLLGRRNVQLRGRCHWCTNKHCKQMRIMFDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEQ6</accession>
    <name>A0A0D8XEQ6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Groucho/TLE Q-rich domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716701">
        <property type="protein sequence ID" value="KJH42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEQ6"/>
    <dbReference type="STRING" id="29172.A0A0D8XEQ6"/>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001072">
        <property type="entry name" value="Transcription factor unc-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="9">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="636" mass="69086" checksum="C845A994F5CD3D1F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFR5</accession>
    <name>A0A0D8XFR5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716559">
        <property type="protein sequence ID" value="KJH43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFR5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFR5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10419" checksum="ECE25107738368B3" modified="2015-05-27" version="1">MGGFKVTERDFTMDEVKKALNENRVYEMFGSGTAVVVVPINRILYAIDGREEVLSFPTTDGNRSLMQRFFNLLQDIQFGRLKRPEWTVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGB0</accession>
    <name>A0A0D8XGB0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_10304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="KN716535">
        <property type="protein sequence ID" value="KJH43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGB0"/>
    <dbReference type="STRING" id="29172.A0A0D8XGB0"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20326" checksum="B6EF32C9D4072085" modified="2015-05-27" version="1">MSNYIPAGEYCWICACKDGGGSDEEPHGHITSLAVKRSYRRLGLAQKLMDQTARAMIETFNARYVSLHVRVSNRAALNLYQNTLKFTASEVEPNYSLKHSFVMSADSELPYETLENPVSTSLEMKQSYRACSPELDIRESNLHSSRAVPESSYLLFFQEMRCPRDAYCETVVCTTMNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGK7</accession>
    <name>A0A0D8XGK7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716614">
        <property type="protein sequence ID" value="KJH42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGK7"/>
    <dbReference type="OrthoDB" id="5868102at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16698" checksum="942D0363A6FB144E" modified="2015-05-27" version="1">MESTEENHSVVRMRGRPPKEGSEVKSAVQRGLDVLQENCSEETDEIRKLDSQLDHLNDYVSKMEERLKVHNEKLMETLRHQKEEREKRRRSFHERMTQNQAEDTAFQQQMASILSRVDSVRNRQSIHDIVNKMDIPKVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGT7</accession>
    <name>A0A0D8XGT7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_11037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716606">
        <property type="protein sequence ID" value="KJH42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGT7"/>
    <dbReference type="STRING" id="29172.A0A0D8XGT7"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF15">
        <property type="entry name" value="INTERMEDIATE FILAMENT PROTEIN IFP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
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    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="33"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
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            <end position="519"/>
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            <begin position="23"/>
            <end position="119"/>
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        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="522" mass="59757" checksum="92C1D7A945FA0081" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH03</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716600">
        <property type="protein sequence ID" value="KJH43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH03"/>
    <dbReference type="STRING" id="29172.A0A0D8XH03"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="305" mass="34499" checksum="882D663D30CD6A36" modified="2015-05-27" version="1">MKFKIKLATNATILATENWGLNMEICDFVNNTEDGAKDAVRAIRRRLHANMCKNNAIVMYTLTVLETCVKNCGHNFHVLVCSKDFVQDLVKLIGSKFDTPQIIHERILSLIQAWADAFRDHPDLQGVVQVYEELVTKGVTFPATNLDTMAPIITPKQGYEVVTQVDGPLTATPEQLVKLRSDLDVVNSNLKIFREMLTEIVPGRETTEELHLLNDLHATCKQMQLRVLDLIRIVGNEEVTYELLVMNDDFNSIFEKYERFMTNRTGDKAAPTIPVTGDLIDVGQTEITLEEQLSRMSLFLIIMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH37</accession>
    <name>A0A0D8XH37_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716511">
        <property type="protein sequence ID" value="KJH43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XH37"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF58">
        <property type="entry name" value="BESTROPHIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="12663" checksum="4AE1EFA98FA96EA1" modified="2015-05-27" version="1">MTISYNLDVSSVSSITYLKLLLRWRGSIWKFVKVDFALWISGYYIVFAIYRYALNSYQQRSFEKIAHYCDSRLSYIPLTFMLAFFVNVIADRWRKIFNNMGWIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH80</accession>
    <name>A0A0D8XH80_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716592">
        <property type="protein sequence ID" value="KJH43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH80"/>
    <dbReference type="OrthoDB" id="5844821at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="33086" checksum="274A9716AFCD088F" modified="2015-05-27" version="1">MASRRPFDCEFPRTPDREASLADTTAFFDDLQLDDDGCHVLRSVTGEEIRLGADDNVPVELQRVPRASTPVDLNTTVQSEFDVEETEVEVSEIPRGYDPDTLCGNEGVGHLVKPSFQDEKTEISVNGKKAEQFVKDLTENPEWARSIQYVKLNAAMPKEILLNLINHLYGNVNDRPKYLTLLSKLIDEDDLPHFIKIGVGIKVGGDDALMKEYLHFDHEAVNDRGVVFSEKRNIITFDVENEMTPLFLMQNPTYDLIDLIVRLSCERPTCITFRLDKLFRAIVSTADHMVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHG0</accession>
    <name>A0A0D8XHG0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_09858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KN716498">
        <property type="protein sequence ID" value="KJH44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHG0"/>
    <dbReference type="STRING" id="29172.A0A0D8XHG0"/>
    <dbReference type="OrthoDB" id="1735at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12873">
        <property type="entry name" value="SPRY_DDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="281"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="489"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="721" mass="80167" checksum="ADF25756D7C7831E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHG5</accession>
    <name>A0A0D8XHG5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M16 inactive domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716585">
        <property type="protein sequence ID" value="KJH43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XHG5"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="559" mass="61488" checksum="4191949F19A41285" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHI4</accession>
    <name>A0A0D8XHI4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_09888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716501">
        <property type="protein sequence ID" value="KJH44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHI4"/>
    <dbReference type="STRING" id="29172.A0A0D8XHI4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF566">
        <property type="entry name" value="P-GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="84"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="382"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="748"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142634" checksum="212FAB2AF8FF1184" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHV7</accession>
    <name>A0A0D8XHV7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Disintegrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716489">
        <property type="protein sequence ID" value="KJH44230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHV7"/>
    <dbReference type="STRING" id="29172.A0A0D8XHV7"/>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032029">
        <property type="entry name" value="ADAM17_MPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16698">
        <property type="entry name" value="ADAM17_MPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="482" mass="53743" checksum="FA4F80011DE953A2" modified="2015-05-27" version="1">MVARVNEIYTAMNWDEGEEETDLDRGRFVNMGFSIKELKILDKPSNQPGHYNSRDITNNGIWNSNRLLEAFTREEGSTEYCLVHLLTAQSFTDSAHIGLAYVADSRGGPGGICSDSAFVCSTPTYALVLDRYISFNTVFTSAIGNTGLQDYPLVTKEAEIVVAHEYAHSWGAQHDGLERDVNGRAECLPDYSEGGSYIMHMYAQNGYDPNNIRFSPCSRRSIRRMLERRWYRCFEPEKASFCGNGIVEDGEECDDGNFLSMNGSSNCCTRECRLTALAQCSPHNQPCCNMSCSYYPANHICLPEDPLQCKASSYCTGRSGECPVAPAIADGSPCIEEGECKNGVCLPYCERQSIAKKSCICEEVHLSCRRCCRDTNGSGLCEPEIGAADLVDGTWCTQGYCRKSRCVNEVADYVTRHLDVLTDRNRIWPMIQSNIVGIIVLLSFIICFPIGYCIKKSDDRELMSSRLAGRVRTVNVIRRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI33</accession>
    <name>A0A0D8XI33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716564">
        <property type="protein sequence ID" value="KJH43392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI33"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12427" checksum="C15E8F7EE5D96504" modified="2015-05-27" version="1">MEILLCSGGKLERENENVKLLFVLRNLIGDEILQNMKYTLVLKSVILPNALATSLNEHKFQGSVQYSVESEIDTVITLSLYRQPYQLDISQNFRSLGMWTCTDKAPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI77</accession>
    <name>A0A0D8XI77_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716556">
        <property type="protein sequence ID" value="KJH43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XI77"/>
    <dbReference type="STRING" id="29172.A0A0D8XI77"/>
    <dbReference type="OrthoDB" id="10042652at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8427" checksum="0C808583C8E261EB" modified="2015-05-27" version="1">MWTSWFGGFAEPSDYANAEMPDINLPAIIISSVFAVPYLAFLVILPGVREKRLITLAAFTEVALVGAILTSESNVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIA7</accession>
    <name>A0A0D8XIA7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLQ-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716556">
        <property type="protein sequence ID" value="KJH43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIA7"/>
    <dbReference type="STRING" id="29172.A0A0D8XIA7"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLQ-like helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="288" mass="32497" checksum="94D5C34767AA8C80" modified="2015-05-27" version="1">MDLKASAYRIHLKSIIDLLALCICNGMTKTNEELEATVQFTLFKQQKTVQDMLSYLKSNRFVTVENQNGALSVLPTQLGRAALVSALPPDAALFVFADLQQATRAVALDTELHMLYLVTPSNCSIWQGCDWNHLHNIFIKLLPAEKRVAKLLHLRFFSALALFDIINEKSIDEVASHFKISRGTLQTLQQQSATYATMVVAFCSRLGWTYLRDLLHGFAIRLAFGVRKELTELVSIDGIDASRNNSSDGFNEWLFGESKMRLIDAATILRQRAIRAVEEHLRYGNVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIG5</accession>
    <name>A0A0D8XIG5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716547">
        <property type="protein sequence ID" value="KJH43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIG5"/>
    <dbReference type="STRING" id="29172.A0A0D8XIG5"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF70">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="23054" checksum="2B81C2AAD5094434" modified="2015-05-27" version="1">MSFVDVDKKNNHTVHTSFAKKPKFGHLSEQIKDLCIWSSQRIRAVQTASPLEEQATNIEYWKVLNEIDTGICEGLTYNDFVLRYPKQFAERDRDKYHYRYPSGESYEDLVSRLEPVIMELERQSNILVISHQLPYLDVPLHTVIKLTPKAYSCVVEMLQFDVNATSTNSSDKLQRSLEPNNQNPPQSAFASRDNLLADSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIZ0</accession>
    <name>A0A0D8XIZ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716463">
        <property type="protein sequence ID" value="KJH44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIZ0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="69" mass="7909" checksum="55E867BCBFCE6D37" modified="2015-05-27" version="1">MYVSSLILKYKRYKRGFHQHLLSFDELRDTVLPRGNWSVTPCTQVSTGRPRPSWVESRSGVLSDVISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJE8</accession>
    <name>A0A0D8XJE8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTP-ase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716663">
        <property type="protein sequence ID" value="KJH42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJE8"/>
    <dbReference type="STRING" id="29172.A0A0D8XJE8"/>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="564" mass="62239" checksum="783F3B37643B9A46" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJF5</accession>
    <name>A0A0D8XJF5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KN716663">
        <property type="protein sequence ID" value="KJH42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJF5"/>
    <dbReference type="STRING" id="29172.A0A0D8XJF5"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="255"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="500" mass="54705" checksum="EB12FEF4BAE1C7FD" modified="2015-05-27" version="1">MTISRFTYPFLNHATQVLKITRMTSSIAHSLKVADTIEKTRERALLGGGQKRIDTQHSRGKLTARERIELLVDKGTFREYDMFAEHTCIDFGMEKQKFPGDSVVTGRGQINGRNVYVFSQDFTVFGGSLSSIHAKKITKIMRANVLASGVIPQISLIMGPCAGGAVYSPAITDFTFMVRDTSYLFITGPDVVKAVTNEEVTQEELGGAKTHTVTSGVAAGAFENDVDALMSMRELMNYLPLSNADPSPIRACDDPWDRLVPSLDTAIPLETTAAYNMKDVVTSLVDEGDFFEIMPDYAKNIIVGFARMNGRTVGIVGNNPKFAAGCLDINSSVKGARFVRFCDAFNIPLITLVDVPGFLPGTAQEYGGIIRHGAKLLYAYAEATVPKITVITRKAFGGAYDVMSSKHLRGDINYAWPTAEVAVMGAKGAVSILFRGSKEVAKHEEEYIDLFSNPFPAAVRGFVDDIIEPSTTRRRICEDLSVLESKKLTNPSRKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJM5</accession>
    <name>A0A0D8XJM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716653">
        <property type="protein sequence ID" value="KJH42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJM5"/>
    <dbReference type="OrthoDB" id="5818482at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26978" checksum="74190FFB9C4CB05F" modified="2015-05-27" version="1">MINLQYSESDVNVKDGICYGLKYRTMGQVTSCMDFLSPIQMLFLMKIGWEAKDRESIRFFVTVSLSVLSAIHLFCTTVLTIYSAIIIKIRFYSYHYQLVIGALVIFTGIFHFRFCCTFFFLGLPFAIGMYSIIQGVVSWRMKCHGTIARAMNVFGAALALLLLASTIFGIYCWFHRNNTPKSLTRHCHWFPKTEAYCIRLIHFSHPYIDWLQSETEREIAVLQVREYRSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJQ8</accession>
    <name>A0A0D8XJQ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716502">
        <property type="protein sequence ID" value="KJH44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJQ8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="60" mass="7038" checksum="79B459983B2AC5AD" modified="2015-05-27" version="1">MVKERYIEPLFSSTILFIIKSSKVMHLLIYSQHFLISSLNHNTSIHFVVDQTHVLIIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKH3</accession>
    <name>A0A0D8XKH3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716483">
        <property type="protein sequence ID" value="KJH44314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKH3"/>
    <dbReference type="STRING" id="29172.A0A0D8XKH3"/>
    <dbReference type="OrthoDB" id="5872528at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="33786" checksum="DEA909FB02E8C88A" modified="2015-05-27" version="1">MSEEEDDDVGIKPGTVIDSHKANYVVISLLGEGGFGAVYKVHDQKDHRKEYAMKIEKKIEQRRHSKLKMEIAILKLVAAERRQSHFTSIIDRGKKDTYFFLVMELVGKSLADLKAHRPNKVFTVPTSMGAGIQCLEACEDLHKHGFIHRDLKPANYACGLGSKKRVGTIRFASIACHKNMEMGPKDDCESWFYLLLDITIVGGLLWKSKSDKNDVLKVKEQMRTEKRDVAFGLISCREQLYKMLDYIDSLKYHDHVDYEFIYKLAQQAAKCAGGDVNDPYDWERTTEATATTTIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKZ4</accession>
    <name>A0A0D8XKZ4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_09541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716474">
        <property type="protein sequence ID" value="KJH44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XKZ4"/>
    <dbReference type="STRING" id="29172.A0A0D8XKZ4"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="12">
        <location>
            <begin position="413"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="633" mass="70823" checksum="24254BAF6110BAC6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL02</accession>
    <name>A0A0D8XL02_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_09481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KN716468">
        <property type="protein sequence ID" value="KJH44499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL02"/>
    <dbReference type="STRING" id="29172.A0A0D8XL02"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012475193" description="long-chain-fatty-acid--CoA ligase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="73"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH44499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="274" mass="31085" checksum="A723837BC60BCEA9" modified="2015-05-27" version="1">MKIFTLIFWARPVNADDPKSPWRNINVINGELTTTIYEHCKTINNDCFGTREVLSIHKELQKNGKIFEKWEMGEYHWRTYEAVENRVNLIASALSSLGCKKNEKVIIFAETREEWMTTALACFKSSFPVVTVYATLGEEAVEYAIKEVNAHTVFTSENLLPKIQKIISNGADIRTVIYFESPDPEYNRNYEQESAKILSFNELLNIGKPGPIDNKPSPEDIAVIMYTSGTTGNPKGVIISHENIIAAVAGQSQYPENMIMGRSDEDIDRHMQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL52</accession>
    <name>A0A0D8XL52_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin tail</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716412">
        <property type="protein sequence ID" value="KJH45353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL52"/>
    <dbReference type="STRING" id="29172.A0A0D8XL52"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="4">
        <location>
            <begin position="9"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="231"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="596" mass="69666" checksum="3664983D58952948" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLM4</accession>
    <name>A0A0D8XLM4_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_08421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716402">
        <property type="protein sequence ID" value="KJH45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLM4"/>
    <dbReference type="STRING" id="29172.A0A0D8XLM4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9908" checksum="3367CFD04C65C5B7" modified="2015-05-27" version="1">MVTGIGFSAFSRIGLIPSEALQLQKNTSEIEQKSDGRGSSRSGSSHEVDLVYEPVCRMSFQDGFSRIIVLVGSPGVGRYITIANHFTLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM41</accession>
    <name>A0A0D8XM41_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716443">
        <property type="protein sequence ID" value="KJH44864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM41"/>
    <dbReference type="OrthoDB" id="5876984at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12503" checksum="2827011E93B24909" modified="2015-05-27" version="1">MIQTSDSCTLHRNREVMQELRMVLANRAREFEKREQRALAASYGVADMSEFMVKSKAPIENCTSNEQFGTRDIDDNVAIPVNHEGPRYRMPSDLLAALSVQSVVETTIGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPC2</accession>
    <name>A0A0D8XPC2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_08304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716395">
        <property type="protein sequence ID" value="KJH45654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPC2"/>
    <dbReference type="STRING" id="29172.A0A0D8XPC2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335812" description="Ras-related protein Rab-13" evidence="12">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH45654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="215" mass="24037" checksum="92EEDD1F207CFF94" modified="2015-05-27" version="1">MGSSGAFLIGLLVTGVRPLMARRPYDLLFKLLLIGDSGVGKTCILYRFSDDAFNTTFISTIGIDFKIKTIELRGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNAKSFDNIAKWLRNIDEHASEDVVKMILGNKCDMTERRVVSRERGKRLPRTMALETSAKANIHIDTAFYELAEAILDKMPAQTEEPRVTINPLDSGKSGSTGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ43</accession>
    <name>A0A0D8XQ43_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716382">
        <property type="protein sequence ID" value="KJH45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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    </dbReference>
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        <property type="entry name" value="UTP20_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="1">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="2">
        <location>
            <begin position="676"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="113902" checksum="611AC32070E6BE57" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQW4</accession>
    <name>A0A0D8XQW4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
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        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
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    </dbReference>
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        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="358" mass="40083" checksum="BABB56DEA82C7BD8" modified="2015-05-27" version="1">MKSNTQMRHCFIVLYNLTRDMEICKELEEQRRNFISLLRRNPVPHSSLDLALETLQFLRKVVIYEKELLAVLTSHGRWICAMEPTELVIRNVVMMVTKLARDENFRLIMGEPISAFDSLNKLWMKNEDKYGAVGGKKLKKGLLQAINEVVSEMTLSCDNISSRASDLINPQDVLIVHHLIDSSNWSTSLNPIKTTRKHRVMSVVCKNDFDITSEIATPIQLCDVGIKMCEATKVLLSGVAVFPDGSCLVPAGGLSICLSAQRHTVPVYVLAAFYKITPLFVPDDVMININKAPGLPFSYSASFCGLVEVVRPMYDIIPASLVTLYISNSASILPSHVYRLIGDYYHPEDVAESQDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM0</accession>
    <name>A0A0D8XRM0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_07542</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRM0"/>
    <dbReference type="STRING" id="29172.A0A0D8XRM0"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="42"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="50297" checksum="C0F6975833B93795" modified="2015-05-27" version="1">MSTEEIPPKNNVAYEHSHKDFEVTQHIKLEAESPSTTELRVLTLNVWCLPHPWPIGSKHRKHRLEKLAEAILRENYDIVGLQEVWSFKDYMDMTERLSESFRFHHYFHSGFTGSGVCVFSRHPIVSTLTHRYSLNGFAHHIHRGDWFGGKVVGLVQVEVGEVRVNFYATHLHAEYDRKNDLYLPHRTAQSFELSQFIRHTSCGADIVVVTGDLNMEPDDLGLRLILSQTRLLDAWRIAHPISLSTEGSKIASLSNNVRGVENGGTCDRPDNCYSSEKSKLKDESKRIDYIFFKSGRMSISLEFCDVAMNKIPNENINYSDHVALCAHFKIQDNESYQTCEWESNRPLLIEAIGIVSGGQRRARSDRTWFMCGAVLLFATIISSIFLDDVLPFMAFISPVLRFILTVILAFCLWYGVIGLTLERKALKAAKESMQQLLNALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSY5</accession>
    <name>A0A0D8XSY5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716328">
        <property type="protein sequence ID" value="KJH46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSY5"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="14"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="400" mass="44834" checksum="BB85FCC617F085D5" modified="2015-05-27" version="1">MPHNTAYSTLYTPTIGLLYVFNLIVGTGALALPKAFQSAGYAFSILVLLISCSASFISATFVIESLSIGNAVIIRKRKEAQISDSDDVNINENIHSSFEIYEKLEVSQMASMFLGRAGVIFSYFALNVYLFGDLAIYSTTVPKSLMNIICFTSTPENTSFTPPSNLCRNNWPSFFDRFTVYRLCVILFILLCVPMIIIGITKTKYLQLTTTITRWSAFILMIFLASAQMTTNGIAAIPRAVNVHGFGSLFGVAVYAFMCHHSLPSLITPMSSKSGVFAKLSCVYLLIIAFYFTLSLTGSFAFAQIQDVYTLNFLHDDLTSAFYFICDHFLALFPVFTLTTNYPIVGITLVNNMRVLRDMLMQTNIQLSSEDESLLRSEDDHDQDLWLRRNTRPFRIKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT43</accession>
    <name>A0A0D8XT43_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="KN716401">
        <property type="protein sequence ID" value="KJH45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT43"/>
    <dbReference type="STRING" id="29172.A0A0D8XT43"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22504" checksum="132D3DBB84836E5C" modified="2015-05-27" version="1">MLLRILNPYLRCRSVGSHDSLRNLSNMATIPYVIENEGRIERSYDIYSRLLKDRIVCLMTPFNNTGGSVTAGLAIYDTMQMISPPVATWCVGQASSMASLLLCAGEKGMRTALPNSRIMVHQPSGGAQGTCSDILIRAEEIQRLKKRTQEIYVHHTGQTYEVITFIYLDEFTVVKGILLYYTYCLGNLRFAFRPCVEDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XT83</accession>
    <name>A0A0D8XT83_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_08366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12747" checksum="ADEBD87D404ACC93" modified="2015-05-27" version="1">MLWDLIKESASSDFAWIGMKTQSTSSSTHNSFSNFDKESPIDGCAVIDHNGVWSIRPCEQLRPFVCQMVVDKICPEKKSSILVDQMLNNTNQFGYVDIKRDDIIDFFENYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV41</accession>
    <name>A0A0D8XV41_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV41"/>
    <dbReference type="OrthoDB" id="5827163at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
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        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335950" description="Protein quiver" evidence="4">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14342" checksum="4C112B98B6638740" modified="2015-05-27" version="1">MLKVIVVLVIVFPNVLCITCYECTSMQGQDCKYTATTCHYGIFGCVKIAAYSGGVDKMGMWYDQDKRIISIIRGCALPPLGGVDMCEQTSILGSRILKCTCFNDYCNSSENFTVFFSFIVTILSVFIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVP5</accession>
    <name>A0A0D8XVP5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxypeptidase</fullName>
            <ecNumber evidence="5">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="5"/>
    <dbReference type="EMBL" id="KN716289">
        <property type="protein sequence ID" value="KJH47892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVP5"/>
    <dbReference type="STRING" id="29172.A0A0D8XVP5"/>
    <dbReference type="MEROPS" id="S10.A59"/>
    <dbReference type="OrthoDB" id="735686at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF418">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013198292" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="466" mass="53265" checksum="22826A34EB2AB07A" modified="2015-05-27" version="1">MLWIGLLSLLTLCLTEEIKQLPGVDFEVNFKHYSGFFQVSDTHNLHYWFVESQNNPEKDPLIFWFNGGPGCSSLDGLLNEMGPYVVNFDGKSLRRNPYSWNKMASVVYIESPAGVGYSYATDGNITTNDDQTSLENYVAIKQFFKIRQFQTFPEFRNHPTYIMGESYGGIYVPTLTARIIDGLQEFPINLKGMALGNGYVNEELNVDTSIRYAYGHGLVDEKTWNTLENECCKGCADTCDFAKVAGHCVTMVEDIFQFLWSGGLNPYDLYRDCDPNPSINSKRMTHMLRGIAPGYRLHEMMEKNESIMDFVRANEPLYGDAPCLNDSDVITYLNDHKVREALNIPSNLPKWDICSNQVTSTYQKQYGDMTSFVKKIIESNVRVLLYYGDTDMACNFIMGQKFADQLGLKRKLGKTPWKFDRQIAGFKTLFKGLTFITVRGAGHMAPQWRAPQMYYVIRQFLLNHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVV3</accession>
    <name>A0A0D8XVV3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVV3"/>
    <dbReference type="STRING" id="29172.A0A0D8XVV3"/>
    <dbReference type="OrthoDB" id="5853324at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="16756" checksum="ADE30C5BDAA6B95A" modified="2015-05-27" version="1">MIDPKKSCMFASRGNGMVRFHKTSLHRFLAQNQNRFEKNYFEIVMNVFNERFVPFLTGKQELPDADKNDMKKVRFAQTYTSAQITEVWERFFKLIAIHLNDSFELERTKQCNVKSQMTLAPHQHVEEKERNKKRIQCRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWT5</accession>
    <name>A0A0D8XWT5_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="17" type="ORF">DICVIV_05624</name>
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        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNA polymerase beta chain family.</text>
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    <dbReference type="EMBL" id="KN716273">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR20856">
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="6"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
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    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="16">
        <location>
            <begin position="542"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="12">
        <location>
            <begin position="656"/>
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        <location>
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            <end position="891"/>
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    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="12">
        <location>
            <begin position="914"/>
            <end position="1019"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJH48262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131941" checksum="F6B7D1057A33B8E8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWV1</accession>
    <name>A0A0D8XWV1_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
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        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8305" checksum="F635F1E8B6FFE8C1" modified="2015-05-27" version="1">MDFLYMLIRKQFENKYLCNVAKGMSFLDPSSCFDRVHPRTGVSQCPGLVSYCTNSVYASLMREQCPKTCKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXI0</accession>
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        <name evidence="7" type="ORF">DICVIV_04498</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditida</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nematode receptor-like protein srb family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH49358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXI0"/>
    <dbReference type="STRING" id="29172.A0A0D8XXI0"/>
    <dbReference type="OrthoDB" id="5864736at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000344">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Sra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002184">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31216">
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF02117">
        <property type="entry name" value="7TM_GPCR_Sra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="23192" checksum="6825048E4910F0BF" modified="2015-05-27" version="1">MITITLSILVITYRHDDFDELTFSMLNTPTSAAPRISGLFTTLGAISVFVIIGMQTLLRLNKRTRRRLPWSLSSRYQILENMYITKFATCLSLLQLTIYVLYSVGGLGMRAAQRLLFGDDHIAFGTARGVFYLIPLFTFLLPFLTIYLHRRYRLERDSSIEANLCLKSTGMEGACNYEDAIRKLWKTANSERLIKKNIWSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYM4</accession>
    <name>A0A0D8XYM4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_04149</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716225">
        <property type="protein sequence ID" value="KJH49728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYM4"/>
    <dbReference type="STRING" id="29172.A0A0D8XYM4"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012542729" description="Spondin-1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="14">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="15">
        <location>
            <begin position="179"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="614"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH49728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="824" mass="93892" checksum="8D5DE01A4BA2C13C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYP8</accession>
    <name>A0A0D8XYP8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716249">
        <property type="protein sequence ID" value="KJH48972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYP8"/>
    <dbReference type="STRING" id="29172.A0A0D8XYP8"/>
    <dbReference type="OrthoDB" id="5799458at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="EMBL" id="KJH48972.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYV8</accession>
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        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM6</fullName>
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        </recommendedName>
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        <name evidence="15" type="ORF">DICVIV_04816</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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            <dbReference type="Rhea" id="RHEA:13066"/>
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        <text evidence="13">Component of the MCM2-7 complex.</text>
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        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
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    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49037.1"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="MCM_OB"/>
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    </dbReference>
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        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
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        <property type="entry name" value="MCMFAMILY"/>
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        <property type="entry name" value="MCMPROTEIN6"/>
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    <dbReference type="SMART" id="SM00350">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="333"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH49037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="816" mass="92235" checksum="B9283B9222B4FEC1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZI9</accession>
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        <recommendedName>
            <fullName evidence="2">phosphoribosylformylglycinamidine cyclo-ligase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">DICVIV_03805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="16541" checksum="A71E8588BEF9B294" modified="2015-05-27" version="1">MAASRKNDCENASGVSRNAQCQPSRGQRSTLPIGYERKSEPQYTCAPSNTSTTKGEVLLTPTRLYVRSLLPILKGGFVKGCAHITGGGIKENAIRVLDPNSFFALEVDLASWEKPEIFNWLCAMGPVETKTMLPNKVLHELRGPKGVDEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZM9</accession>
    <name>A0A0D8XZM9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716293">
        <property type="protein sequence ID" value="KJH47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZM9"/>
    <dbReference type="STRING" id="29172.A0A0D8XZM9"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="102" mass="11325" checksum="E2638A9C50DBACEB" modified="2015-05-27" version="1">MNNVNLKLEFSGGCEFLVGNQKEHEVSIPSDEDFVTVSDVLGYVRDVLLQNCDRHDLLIEGDTIRPGVLVLVNECDWELLGCEKCHLHNGDVVTFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0I4</accession>
    <name>A0A0D8Y0I4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716230">
        <property type="protein sequence ID" value="KJH49549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0I4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="269" mass="30183" checksum="E47DF9523FB9CB54" modified="2015-05-27" version="1">MSSVDVVMGMIANQLICTSTVDTDPESITDCSASSSASQSTIEKGLDAHAVCNQIISELLSIEVTMYSQIEAFRTKRKLLEKAKQSANQGNTLALTNVEAATSLVRIFADIAARYSVTVEHWKKKGFDQIDNYRVTSVDNESAHSSCHLDDEIEIIDIESTRNFDQNDVVYRDKDEINRIGSEPCGTKEAVFVLQHHDSKNTAKKSRNKKVSLRNNSSFIDVNHSNDLNEYKRIRQDFVDRGDATDPKITSLEKSHDQTSQVQFFVHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0T0</accession>
    <name>A0A0D8Y0T0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716276">
        <property type="protein sequence ID" value="KJH48201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0T0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="237" mass="26991" checksum="3A96D5ECDB94444B" modified="2015-05-27" version="1" fragment="single">MPPKKAGKKNKDDNWDDELIEQKLASLMTKKVANEVDWDAESDEESVKQEKPAPRKAAFSMLMADSDEEKNASSHSDTEKDVTEKIPYEKEKKQENICVKHDIKKKGKKGKKVKHEVEDDLDAILATLEYDHKVVPADKSRKTDEKKEKSDLGFVAEACKEQKVQQIENEEALELSKTAEVVVEHTKKKKKVKDRKETNTRDNDQNIKEEENVKNDNEVHDCGDVDEAGGDGDEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y161</accession>
    <name>A0A0D8Y161_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y161"/>
    <dbReference type="STRING" id="29172.A0A0D8Y161"/>
    <dbReference type="OrthoDB" id="5834495at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="356" mass="40981" checksum="787AF89CD655FC33" modified="2015-05-27" version="1">MSQLDADRGFNSTERAMLSVEGVGLSNARGLEHIGANISPYHMKDYSKLMQDKTNGTVHITGTKTRPELYCYVNDSHDETSIIRRDISIVQLGSRFRVSFSPKNDTFSIRSLLDESVCFRKKMLFDTQSLQVNYVNPVNDQIVSNVIREQILEELKRKVLEVEKNSSSKVGVLLQKLNAIYPEKTLALKNMDMRALGSDDHELLRCSRLRAEIEWLHFRLEVSREALLGLKHSIAKDETVLEKLRNNLQICSSKDELSRNVQALQTELDHLPAAEVIAETIDNHIQLVKDETDLERQILDLEIEELRLELRLTKTKSKKFREETIRLNGLANTYEMNYTQFRAIIREIQDSDSCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1T7</accession>
    <name>A0A0D8Y1T7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716200">
        <property type="protein sequence ID" value="KJH50650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1T7"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="17617" checksum="D7E8674375EBA43C" modified="2015-05-27" version="1">MDGLENDVTKTSNTPIENVVREVLNRNVRSTEDIAPNITMDDTMEDMENVSSSSSSSPMLTEPLSTSSITLTSETNEGTTIAETTISSTTESFTPQTNDNIADVLSKIFSKNLNSKSIAAKDPRGATKSVASKIDQQKTVKTPQTKESTSTSSVDKTSKTMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2J0</accession>
    <name>A0A0D8Y2J0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716256">
        <property type="protein sequence ID" value="KJH48786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2J0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2J0"/>
    <dbReference type="OrthoDB" id="10030336at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="186" mass="22440" checksum="32FC4D7C14A0A367" modified="2015-05-27" version="1">MIGLLRIENTRRRSMMMTESINRLVVLQLRIGYQAENTKISNRSSLYQNQFWKHMIPFSNGFRISKNLPRIEKRLRHMIYDVNVSRENKKLPIKPRLQSTYVTSLNHCNIRYVVYGWCEKHSRILHTKYYTFFVISHYIESKFEMPVRKKHGPYDIIADDLYDCRIPLHNELAYQHGIHFEAKFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2J3</accession>
    <name>A0A0D8Y2J3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2J3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2J3"/>
    <dbReference type="OrthoDB" id="437693at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="4">
        <location>
            <begin position="106"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="318" mass="35344" checksum="997B1278C926B6E5" modified="2015-05-27" version="1">MSFNQFSESSTKCGTSIDRQAPGDDAKQIKSIGLFVDISDQQCPLIFHEIYDVKFLGLEKCHPFDAGKWGKVYAKLKNWQLVSDETIVRPIEATRCDLLIAHSKWYQCGGTVAACRIALDRGWAVHIGGGFHHAYRSSGGGFCVYADISLALKLLFSTNLIEKAMIIDLDAHQGNGHERDFGNDDRVFILDVYNPRIYPHDHKAEEGISRSVHVGSMTSDAEYLSLVKRHFTAALLKFKCDLVVYNAGTDSLENDPLGCLSLSKECIIQRDELVFRICDQNKTPIAMLTSGGYLLESASVIAASIRNLHNKDLIQLKA</sequence>
</entry>
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            </authorList>
        </citation>
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        </source>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="97" mass="11437" checksum="2F2374BDF83EEBD5" modified="2015-05-27" version="1">MIFRVSLLELLVCIVICAITLDTMGRIWYMLCIIFIATMPMTTLTQEVIKRRIGMRLPNMLHIKSTIEKRRIGMRLPNIIYLRSEPEKKNIWESISL</sequence>
</entry>
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    <name>A0A0D8Y2R9_DICVI</name>
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        <lineage>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="11 12" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">HannoverDv2000</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
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    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">HannoverDv2000</strain>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10938" checksum="219BCE2515A3FC18" modified="2015-05-27" version="1">MLETAAVITAYALHEDLRGGLSSQLQMGLSRYNRSTGVQVAWDQTQQMLSCCGVTNSSDWSALGAVPDSCCIEATSGCARELAPIHTSGCMEKVESELSGCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y372"/>
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        <property type="match status" value="2"/>
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        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="328" mass="36380" checksum="CAF15433AA553B82" modified="2015-05-27" version="1">MDEATVRNIDLNSCTTSFSFADKRSADTVAILCKNDAIRQEYFRLKSQLSKSEVLRKEPNLLEKKSTGQSNFYMLGRATKPVEMTRGGREGNNAFLKFESSTGSYISSVATLVEKGVSYKDILKISKEPNTSHCINMKELDSMVVVAARMGLRDLASAFAEGPARCNMNDLHRLTLMADASLPERILPASVLKKGYNNANITPLHTAAINPNVKIIERLRTVEPNINIPDSNTWYTIHYAAVCQGAEPLKFLLKIGITPSIFNKQHESPLHVAARAGRRETIEVLLHAISSLETPDKCSPTFNPEKSLMNARNKSGYTALCLAVQFQR</sequence>
</entry>
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    <accession>A0A0D8Y3D3</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3D3"/>
    <dbReference type="OrthoDB" id="5789697at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="15515" checksum="A44E64359ACD6393" modified="2015-05-27" version="1">MSKKYIKVECFKQKVSAIYRSEKLRECVDRFCPPGTFCDQRVGPCEKPPCRPIILCIPDIYNGCVGHSCPTGEVCVERVRPCIGRSCKKTPICAKPGTCDAIICPPSHKCTAEPTPKCIKSIPTVSTVIGNATLRIENKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4N7</accession>
    <name>A0A0D8Y4N7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome C1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_02009</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="14">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH51818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y4N7"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000011">
        <property type="entry name" value="Cytochrome c1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
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    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="60"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH51818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="284" mass="31529" checksum="EB1B2622EAB7C36E" modified="2015-05-27" version="1">MQWVVSQGVSRFGAVATSLAIAGGGLIYALENSVHASSDAVHPYHLPWSHRGNFSSFDIASVRRGYEVYKQVCSACHSMKYIHYRHFVDKIMTEEEAKAEAADVIINDINDKGAPIQRPGILTDRLPDPYPNKKAAAAANNGAVPPDLSLMALARHGGDDYIFALLTGYFDAPAGIKIDEGKAYNPYFAGGVISMPQQLYDEGIEYKDGTPATQSQQAKDVATFMHWCAEPYHDTRKRWAMKVLAIIPIAAVILVYGKRYMWSFHKSEKFIWKTIKGREAPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4P1</accession>
    <name>A0A0D8Y4P1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">7 transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_02014</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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            <end position="174"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="20037" checksum="8A207D1F6BAC81E3" modified="2015-05-27" version="1">MEEDEILTKKTFKERRGPLNDRLSDGWTERRAPSGRPAKRWMDQEEPCTSSLYLRNTTSKHNHCWIEKPAECMQGTALSKRVLGSGLVCSTHYDKLYSTCRIPGDKVDKLMKYGISKHIVVLVDGCIYKVMLCDKKNRIHSINQLAKIFTEVLSRKEKEHGSAGKVAALTVDARLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6K0</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5843041at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336516" description="Activin types I and II receptor domain protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20932" checksum="2D7D289F5671510E" modified="2015-05-27" version="1">MWITVVLVVTVSSIYGKLICTKCPLHMSPSGHTNCTETFVNKYFNGTIIANCLQLHEGGQFDEGPAVCHREAEKTQCACSTKNNCNSPLSPIADFKFVDEPILEGYQLIPMISTDESDNGVPIITDLPHIDVQTEEILSHSSSSSTIDSSSSSTIDSSSSSTSSQISPHSSSSTDYSTTLINCVMKIFVTVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y781</accession>
    <name>A0A0D8Y781_DICVI</name>
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            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge protein</fullName>
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    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716205">
        <property type="protein sequence ID" value="KJH50451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
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    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="244"/>
            <end position="305"/>
        </location>
    </feature>
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            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
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            <end position="174"/>
        </location>
    </feature>
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            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="305" mass="36068" checksum="822F27F9795A2B62" modified="2015-05-27" version="1">MFVRYSPETIACACIFLAARTVQPQVPLPDKPRNWYELFDASDTDVNAIALMLLNLYTNQKAVSWREMDEKIEKLRSKIEATQKAAKAQLVAQKITNEKKKLEEDSDRDDARKRRAKSRSRSRSKSRSRSPKRKYSPGRRRRDSPDRNSRNKIRSGKGGRDDRRDRDRRDDRREEKRRRSRSRSKSRERYSDRDRDRVKERSKVREREVYQSLGKRVRPRSPTPPARFRNDMPDENTPLEEGVDQLTQWRERCSEHAAAFKAVLDECNERVNSRTNTEETCHQEMSDFIHHLDQCAMPKAFAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7P2</accession>
    <name>A0A0D8Y7P2_DICVI</name>
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        <submittedName>
            <fullName evidence="15">K+ channel tetramerization domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_01820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH52009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7P2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7P2"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000074">
        <property type="entry name" value="SHaW family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH52009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="442" mass="50878" checksum="8B8C1AA9DB562F07" modified="2015-05-27" version="1">MDTEHRVILNVGGIRHETYTHVLKKIPATRLSRLTPNLANYDPVLNEYFFDRHPGVFSMILNYYRTGKLHYPTNVCGPLFEEELEFWGLDANQVEPCCWMTYTQHRDTQETLAVIESLDLDGDPPTQEEIAKKFGWEDDYYSGTLSKWQQIKPRIWALFDEPWSSQYARIISCCSVFFILASTISFMLKTHPSFQIPQITVMYGLRIVEHDGFSNFARSIDTHKPYTAPHPYFFYVDLICNSWFTLELLIRILFCPSMRRFLRSPLTVIDVISTSAFYFEWLLHAILIKTGSLVTIDFLSMICVLRLFKLTQHFSGLKILIQTFKASAEELALLVFFVLLAIVIFAALVYYAERSQPNPENQFTSIPAGLWWSLITISTVGFGDMVPRTYLGMVVGSLCALMGVLTIALPVPVIVSNFSNLYSHSQARAKLPKKRRRVLQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y884</accession>
    <name>A0A0D8Y884_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_01644</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y884"/>
    <dbReference type="STRING" id="29172.A0A0D8Y884"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="37979" checksum="D73FCA61066AE92E" modified="2015-05-27" version="1">MRAGEYDPLHLDVAHFSNKSFKNTLLESCATTAYGSADNTSYVIVQLASVITGSTRVWVRERAAEKFSGIFHDPALGRSCLFEESRRIKGKNNLPERVKKIDLGNKGFKEFVEKPNIIAVVIAVLIIFLTIVFYLYRSIRSSANTILLVGLSDSGKTLIFGKIANKYNELTTYTSFQENILDIDVKGSHLKIVDFPGAERLRKQLTERWLIKERSSLRGIAFVVDSASFSKRSRDVAEFFYDVALESGKKVPIIVVCNKQDHGLAKSSQVIRDSLEREIALINKTRAAALASTDGSSLRTTLTDSGSGFSWKDLPITVDFLECSAVDGSSTGLEALRCWIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8H8</accession>
    <name>A0A0D8Y8H8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716195">
        <property type="protein sequence ID" value="KJH50881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8H8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8H8"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="83" mass="9007" checksum="21279D6146E1A7E1" modified="2015-05-27" version="1">MSTLQPVNPKPFLNSLTGKPIVCKLKWGMEYKGILVAVDGYMNLQMANAEEYIDGNNTGNLGEILIRCNNVLYVGGVDADSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8L3</accession>
    <name>A0A0D8Y8L3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716163">
        <property type="protein sequence ID" value="KJH52552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8L3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8L3"/>
    <dbReference type="OrthoDB" id="5866893at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="387" mass="45102" checksum="A806E3F8E5FBE282" modified="2015-05-27" version="1">MFVGKKLEIECSPLCNGFTQQHWSVTNLKPISIVDNVESENEEEEYEEMEDDEEDDNAFLFPHSTRGQSELDPATKNTCSTFPCCLVCGRISTPKIRLFKWPEDLQLRRSWLKFFRLSLDSFDNCQDPYICNIHFDADQFLCEGDRIFWKRNPFPSFQQRRSIMAEPFPWEIEQNISKKSKASHPVAVVSLPENPNIFYEFSYTRTSPIDFSKFYSCLTCRRAKTDNCYWTSCKIYSGPVCQETQDHCTKLVKSTNHNEVGQSSSMHGNTHIANLEQTPFSGTKSLDFCSEKPSQNKVRGHQSIFTPASLRKSRQWHVRQRWEKRPLPQCHLCRRVLPSTELLVQHLLNHIKLRRTCSICGSKLSPDQHVRMRRMKICSMCSKKCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8M0</accession>
    <name>A0A0D8Y8M0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyl hydrolase family 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8M0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8M0"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336566" evidence="8">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="9">
        <location>
            <begin position="264"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="10">
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            <begin position="452"/>
            <end position="569"/>
        </location>
    </feature>
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        <location>
            <begin position="592"/>
            <end position="635"/>
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    </feature>
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        <location>
            <position position="190"/>
        </location>
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        <location>
            <position position="318"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH50931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="656" mass="74464" checksum="C21BAFBA399B185C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8N6</accession>
    <name>A0A0D8Y8N6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5829881at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013334459" evidence="1">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="32271" checksum="5668F08E2F0B132E" modified="2015-05-27" version="1">MIFTHFNLLITEVLFLGEESSFNLTVVESAVSQTAFTLRWPALNTSDIDHRKFLGYDILYKEVAWEDPNLSIDDDRSSCQDTDSWYYHFEGVNDNTERINGTGPEYVTAMIGNNHIKPHTLYAAYVTTKMVRHQGARNAVSNIAFVRTRFAIPDPPRITKAEALGTEEILLEWDPPAQPNGDISHYVVSWRAMGDAYMNHYMGTAVCYDDISRGFDLSLGVVKGLREPATTPAPRAVSVLMGENADTQTDTCPRNEGCCKCSPKTTSDEGVESQTAFENAVHNVVFVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9J2</accession>
    <name>A0A0D8Y9J2_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KN716161">
        <property type="protein sequence ID" value="KJH52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9J2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9J2"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="370" mass="40043" checksum="88CE45B51900450C" modified="2015-05-27" version="1">MWDFRQYKVPSAVVSSSSSSSATILCGPNGSSGTNSSSERNDRSGSRSGSPPSQFMGPPAPNHGVAAPHQKNLARVQATAPPVVTCSPSSLSTQSVAPQIATVGATEHTNSSAEVSFVGYAKIILQPCCLEGQVLSVFECPVCLEYMLPPYLQCQAGHLVCGNCRPKLQCCPTCRGPTPSVRNLGLEKIANTVRFPCKPYSCPCPGAACKWQGALNDVMDHLKKVHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGYNFMLVLEKQEKFDHGHQVFYAVVQLIGAKKEADNFSYRLELSTHRRRLCWEATPRSIHEGVAHAIQLSDCLSFDTLTAQLFAENGNLGINVTISMVRAQVRSCSIVEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAG5</accession>
    <name>A0A0D8YAG5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAG5"/>
    <dbReference type="STRING" id="29172.A0A0D8YAG5"/>
    <dbReference type="OrthoDB" id="5853681at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000058">
        <property type="entry name" value="ASpartyl Protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF8">
        <property type="entry name" value="ASPARTIC PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="73"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="406" mass="45581" checksum="7C4E042B9D664172" modified="2015-05-27" version="1">MVIKMKTLIVATVIVVALHAITYKMETRSLRSLKTRSLTDDQNDNYLEEYNRFRAELPKNGSLPLIDYYEDVNVGNITIGTPGDCLRFLILGQTLFLLMDTGSSNLWIIDTNCKRKVCDGYFGNNYTRNKFDRTKSSTFLAKKKAVKLNYGYGWTKGILAMDVVSLAGHTIKQQEFVDATDIGKFFGIMPFDGMFGLGWPERSLDKITSPMSNLLPMLDAPLFTVWMDKRSKNGGNAGLITFGAIDTKNCESKIEYVPLSTKKTWQFRLDGFSVGDFSTSKSEEVLSDSGMPFSAVPHHIMRALAKQTHARFDFKHLMYTVDCSTMKSQPDLVFTINGINYTVPSEAYVVDIGFGNGRCALAFFAKFSGGFGPAWILGNSWIRTYCNIYDFGKERIGFAKSIHSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YB23</accession>
    <name>A0A0D8YB23_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
        <property type="protein sequence ID" value="KJH51746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YB23"/>
    <dbReference type="STRING" id="29172.A0A0D8YB23"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="213" mass="24561" checksum="0252B632927AB8E8" modified="2015-05-27" version="1">MYQDEKLALEVGLIYLNYSAAPSAYWDRIWSLVGVVKLDIWSGRVVVGNKLLPYMLVISMENTNRLSGLFSRKATIIIGKIRLCESVADRALLSVEGQAESVRAAFLKHPDYVGIPYKDPPRTMGDGFAILQSALLHFYYHQDILGYVTVDEQSLSTQRPVWESIWRFDHNTVISYGPWAEHQRTLLYTFFFPSDYQKRGVWEDVLSGFRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBI9</accession>
    <name>A0A0D8YBI9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RIH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_00327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBI9"/>
    <dbReference type="STRING" id="29172.A0A0D8YBI9"/>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MIR_motif"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719022">
        <property type="protein sequence ID" value="KJH39945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="348" mass="39957" checksum="97E55D9C02859E71" modified="2015-05-27" version="1">MDARICLKRLYLNDIKAEEKKSQSADEWYVTEGYRAVNQALGRVLRHAKDFGVVALLDERFAKISKEYFPAWIRTSIKVFDKRFELLSSVSKFFDRRKGEIMPLASNGLIAKEREIPDTVKRRLSSTTTNYYEKENCLDYNLYLRPPCSLEHLTKNISAKNEYSEVTSILSICGDEISTECTSSSSMTGADNTVDFEVASTSEFNAQPLRKKLKLTRGTVDKLQVSTKRQPAFDIQSIPSGFDKVLQMTVKQYFNVLTSIGKKEKVAAFVMKFAKKQQTFDELLISLENELLPDYPEAFLDDILLLCFLFMLNVIEDEICLLGTYCILDNNDDKRRILQRSLSLRLEL</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716794">
        <property type="protein sequence ID" value="KJH41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAF6"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="61" mass="6906" checksum="B13EFEB9969913E5" modified="2015-05-27" version="1">MVANNDDFGLNHVRHSSITSQLSGKKIHQSRILLKMQCSYVVRKGFVSDMELTVDKTARDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAI1</accession>
    <name>A0A0D8XAI1_DICVI</name>
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            <fullName evidence="5">MARVEL domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_12409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716789">
        <property type="protein sequence ID" value="KJH41610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAI1"/>
    <dbReference type="OrthoDB" id="5834409at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="66"/>
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            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18180" checksum="B258734CCC11640F" modified="2015-05-27" version="1">MALYDMKELPHLVKPVTLILIIFQMIFVFSPGYRTFGWFVITTTIIQLLTCVFLVLAITLNVTALYNAPVWPVAEMSFSAVFVVFQLINFFFFIVNMFKHFNAFLLFGLVESSLLGLIWLFNGYQWFRARTPSSSTPSNANQTNSTPRFAPTYPAGVNPA</sequence>
</entry>
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    <accession>A0A0D8XBG2</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716903">
        <property type="protein sequence ID" value="KJH41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XBG2"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="430" mass="47142" checksum="A2376863271E7570" modified="2015-05-27" version="1">MSVVMVADVAWIQRGVAKKNPDRIKLDNDQLKQLIEGGVSDSSDIDSEPDAAEHGVRGSSSKEEAESHEVNDESIEDGIDDNATKSGDEEEKAEIEVKADDNLVVIAKIDKDKYVLEVFVYNEENSDWYCHHDYLLDAPPLCIEPIQHDPGNAETGKGSLYFTERALIVDLQGNLIAVGTMESVINIWDLDIMNAVVPVVNLGDKKKGRRRKRDGSDSGHLSAVLSLAWNKITPHVLASGGADKEILLWDLDEIKVAQAVPERTAEIQALSWHPAEESFILHGTLDGTVEVIDCRENTGIASAVKWNHFNPFYALFATDDGVLYNVDMRKPGQVVWSGRAHDGTVGGITLSSVVRGLLVTVGHDEHLCVWKIQNDGTLLKVHSMRQNIGALHAAQFNPDVATVCCIGGSSNDLIRVVDVSKMDVVLRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBH5</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720198">
        <property type="protein sequence ID" value="KJH39816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBH5"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="43" mass="4418" checksum="E982693B853D979C" modified="2015-05-27" version="1">MSLQSSSSKGSHEVVCQAVSVVEENPNASETVVNKPASDGQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBR2</accession>
    <name>A0A0D8XBR2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Strabismus protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">DICVIV_11959</name>
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    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Vang family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716716">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBR2"/>
    <dbReference type="OrthoDB" id="8887313at2759"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
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        <property type="entry name" value="VANG-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="503" mass="57655" checksum="4FF6A28BC1AF8409" modified="2015-05-27" version="1">MSTVSAGGRRGPLKDLRCPARGDVRLMKPRCRGYSQSDVGEPFLPRFSAVANEGLKIGLPPEEYGENTTVLTGITSEHSYSGDDRPVYEPPMGRVVDCQGYLLLLGIKTVLLIVAIWALYWRRAAADFPRLYFARAALSFFVLFILFAFWLFYTVRIFLEKNSKYTYVVTYALSLLDALLYTHYISVIVLELRRIRPEYIITIIRDPDGESKTMSIGMMSLQEAAIQVLRYYEAYFPSYNAFLDKARQSSHRLRNSSQPPGFKMYDIEGLGGDATEISQSNLRALMEATSRRRTTNYNDILQEDCEWERRIKKRKYRLIASAEEAFAQVQNIVDNQAGYKNLCDTMDLATAAQGVFACIMRPLNKYLRQTRQQPRHPAEAVTHHIERCLSMRMSYRTFLQRFFSNRFPSKAGSCFFLVILSLMHWYMLQDIVSESKWSIISDEQSSVSIQHGTTFVLRSHNKDDDAGVQLLCTVSSLPFFNLTEQSRSCNNKFALKIRSESSV</sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716899">
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="197"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="148"/>
        </location>
    </feature>
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            <end position="142"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="KJH41119.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="256" mass="28136" checksum="3D8A6824AA0336F4" modified="2015-05-27" version="1">MLYQQTGTIDLGVINTAVVERSHSIAQPTPIRPYPSSDGFVLYQLYLSHLGSSINGNHSHISCPSIYGSTYWVNVPKRQISTSPNDPSSTTSSLIGSGSMSFTSKKHSWLSHYVKDAYGMDSSQERQPSDKTDYVQKSEHSSSEATTPDTCAICSDRSSGLHYGIYTCEGVVSNFTANISCQSDSRNQDVCAGINSILEINGYSLLIFATGCRELGRDLCDWRESTRCSARQGCYVRCPHLAYTDRAPLILHFPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC01</accession>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718676">
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    <feature type="non-terminal residue" evidence="1">
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            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="76" mass="8898" checksum="B3DDBA9D05F9FC0C" modified="2015-05-27" version="1" fragment="single">MGQELEIIDLKAKQKTMCVGVEMFKKLLDKRCAGFNVGILWRAKKESYQPQFYVRTTETRSIKLLKRKEMVMPGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC52</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716847">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
            <begin position="195"/>
            <end position="282"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="483" mass="54709" checksum="A9974A25A0588F2E" modified="2015-05-27" version="1">MDDFSIMLSLQNNAIARAEAIACSSKRSADPPNPLSDLTPCFLAFDERLFCGDGNDFGIVKSYTGAEHNGNIYSVASNLFPIHSRKVLLSGLPCCATPEDFHNFFSSFGSVEIVWPRKENNDESEHGDHAFAIFFSAESVIELTAKCTFLNGRFFIDVPIRGNHPATINVRVWLRKDRRFYCANFSRSSNMFTKNTVFVGGLPSTVTAGELYTFMSLKYGDVVMTQIEVESDTGYPRGAGCVVFRDREAFVAAIACGQAVMKVEDNNKQIALKPYLVRIAQCDICQTMQTRDFCPQLRCLKYMCETCWEQAHMDLPDHHPLFRASNRRRYSMNSIAINDNQQSAHQVLKQPKCNCEKNTGIAQKFEPRRNRNTDYDMFDCHELSCANPRIHTLSKSSTVHYMIPIFNNEHLADQSPSYFSNSYTRSDLVPSEKHVRARTSFSPTVRRPRRCEATRVQTSMNVTSELNDNSDTIVSSLSQFKLF</sequence>
</entry>
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    <accession>A0A0D8XCB2</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716830">
        <property type="protein sequence ID" value="KJH41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCB2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="18365" checksum="3FBD0F616FA1E8AF" modified="2015-05-27" version="1">METLILLCDYRSTLYSDDRTELTVVTIQSLKFGNSPDTEWSQYDSHSSFLVSMSQRVLHRSAASTKLFYNDANWVILLRDMSTVMVPLNVDEEIRYALKYVKSSPTLNVHGSATLMTVQRSTFTAVQRSRQFNAQRSRQFNVHDSSTLNVQRSKLSTAQR</sequence>
</entry>
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        <name evidence="1" type="ORF">DICVIV_13882</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="CAP"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11710" checksum="A92D8E9F1FAC5756" modified="2015-05-27" version="1">MKGCGFKRSTIHDPVLENAAQNWANVLGNKKDCLVHEDPRRYGENLFFFGAKTFPTPTTTALSVTQSFYMESVGYNYNTGSRNSVAKPSLGLENRSVFRLPAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD07</accession>
    <name>A0A0D8XD07_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716781">
        <property type="protein sequence ID" value="KJH41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD07"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="162" mass="18515" checksum="6EE548BB5FFF354C" modified="2015-05-27" version="1">MAYAFNKEEALHQKQLMISLALLICHAIFFITNHTDDFSDLEKNVALSKPGCGLEQRTIIRYRVSSSHTPYQCATCPIISRKIHLKKESSTQVKTAIRNSETNTPLPPLKESPSECQMQYLHNMVLFTAIYSENVNTAEHRMSQNQAYAREIDYPHKICGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDK4</accession>
    <name>A0A0D8XDK4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trypsin Inhibitor like cysteine rich domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716637">
        <property type="protein sequence ID" value="KJH42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDK4"/>
    <dbReference type="STRING" id="29172.A0A0D8XDK4"/>
    <dbReference type="OrthoDB" id="5788972at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335743" description="Trypsin Inhibitor like cysteine rich domain protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10540" checksum="EF5B40EDD0B4E71C" modified="2015-05-27" version="1">MIFRVIILVITSQILISYCNDEAYDDITIPVTETDIPHQCKTNEVWMECGTCENKCGEPKVQCPRVCKPPQCQCLTHKGYRRDKNGNCVKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDT4</accession>
    <name>A0A0D8XDT4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717090">
        <property type="protein sequence ID" value="KJH40601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDT4"/>
    <dbReference type="STRING" id="29172.A0A0D8XDT4"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="326" mass="37533" checksum="985F4776F6E16B80" modified="2015-05-27" version="1">MRFYSDQPIVLDLVSTNAVDFEAEPNHTVMLRCSAQGQPIPRLFYAWENGTEIEEPGDVPTNVKWRFDDNDSLLIDWDPVQYPNGNVTYILYLSNFVDRVKGPPVRIPQVPYNVNITLQISAENEWGEGRKSPPITFLTPNGGPKNAPSITSIQSKDENVTVIWQSPTIPNGVIKAYTIYFKNTAESDGKPWKIIQLDANRTEYTINRSMGLQENAQYKLKISATNEYYEGPVSETSWFDTYKSDDDNLSVLENVTAYLKNASLIVYVPTKHKYQTYIMYIRPEYGEQYWKYEAINVTESQEEIVIEHFPLDKNVRWAVQYHKNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDZ0</accession>
    <name>A0A0D8XDZ0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">succinate dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_13390</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5"/>
    <dbReference type="EMBL" id="KN717066">
        <property type="protein sequence ID" value="KJH40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDZ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XDZ0"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="17">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="17">
        <location>
            <begin position="139"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="19">
        <location>
            <begin position="463"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="18">
        <location>
            <begin position="951"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR630664-50"/>
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    </evidence>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="201"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="285"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="43095" checksum="BF756FFB28592351" modified="2015-05-27" version="1">MQSCLSKKGKPPPRLGWALSTDPDGKFIATWLGETRVKFSHLYKTLGTTQESLHAEMKDEIQKDGHGYIVSSNISFIPRPDDDLKYLLCLSQHDTFPEKIEIDSIKLVLQYAPRVNLTLASTHRLREGGSAMLACNVDAKPLDNIRISWFKNGNQLLPQTTDTLAFETLKMEDHRTEYTCQASNIIGTSHATLRLDVSFAPRIMSTPQDKEVNKGESASFRCDTVGNPLPTVFWTRAGDDQIIAKGDTLTIDNVRSWQQGEYVCTAVIESFKHAIMSHFLHIRGPPVVTVPNELSASVGESTEMSCFISGRPKPLETQWTKNGEPLNYGSGRMQVRQIPRSYGVESRLTIKELRSVDMGVYNCTASNGIGHDSKGVLLKAKGMSDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF55</accession>
    <name>A0A0D8XF55_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716577">
        <property type="protein sequence ID" value="KJH43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF55"/>
    <dbReference type="STRING" id="29172.A0A0D8XF55"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="36275" checksum="5ADFEECC647A86A8" modified="2015-05-27" version="1">MLSFTSLKLRDVATIGSGSFGRVDLAWSDVEEQYYAVKKYNIHETVEESRVEYVKREKELLSIISSPFIVQLICTHMDKTNLYIVMEFVHGGELINYLDDITDEVLNNTARFYSMEIICALQHIHSKNIAYRDLKPENLLLTQNGHIKLSDFGLAKRIKGKTYTICGTIEYIAPEVFMKKGYDVNVDWWSLGVLIFELFTGNPPFCGDNNELIDAICKASVDIPESVPDSVRRLILSLLNRDPSQRALNITNQKWFDNIDWDEVRCLAIQPPIIPSEFDVNEMAPVVKITDAVDSVQRERDLFADWDEVLPAEADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFL6</accession>
    <name>A0A0D8XFL6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EEIG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716659">
        <property type="protein sequence ID" value="KJH42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFL6"/>
    <dbReference type="STRING" id="29172.A0A0D8XFL6"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="15979" checksum="4628A5B3C16283DB" modified="2015-05-27" version="1">MLESRNKRRYLIIDWLWSKMAFLKRKKVKFSVDLQVCNLSDVPLVNAVLFAKIRLLEGGTFDDCTERVEVVRNSCSWSHRSNFCCRITSDPSSGILERCLCRISIRKEQKGGRSFLKLGFVDVNLSEFAGSGVEGCFCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFM4</accession>
    <name>A0A0D8XFM4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716653">
        <property type="protein sequence ID" value="KJH42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFM4"/>
    <dbReference type="OrthoDB" id="5844717at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="11961" checksum="DE877B0C1EB51BED" modified="2015-05-27" version="1">MRQSSFDWYFCSTCRHLDKRFVGCKGQLLNNYYASITVSQAHAIFGVVAVGKVTFYRLGLDKRNTWKDAKFSSRGIEEIAVVNLNGSCSTLVTNIDEGELVHFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFX2</accession>
    <name>A0A0D8XFX2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_12774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716867">
        <property type="protein sequence ID" value="KJH41256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFX2"/>
    <dbReference type="STRING" id="29172.A0A0D8XFX2"/>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335596" evidence="4">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="367" mass="40955" checksum="E05BB15F4C3522A0" modified="2015-05-27" version="1">MWNSTPILLLILSHNLRVIAVIGVEPSISFFDGNDYMNQCKTRLERRITGLSGVIYSHSLYGRAPYNASRNCFMMLIAPIGYRIRLKVLDFEVNGKNSLCEKDTLHVFDHETVIEPSSSQLQSTDTVTPGPIIGQFCGKRSNISELSISTLNALTLWWHTDSLLPQQHPAKGFRLHWNAFRVTANVPCSSTREFACSHNECIPLQLACDRYSDCRDESDTIYSKQLTVNCENLDIDPLTSVSGFLVLLLSGSIVLLCGCICISCCICCRCLKSIHPPHMKGEPVNCEANVPPPIPPQFFPPSPPKIPLPSATSSFTPRKFTNLDTGNPIHDGGYRSVQIANEYGNPINTNQQHDYTYVKNDVHRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG47</accession>
    <name>A0A0D8XG47_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716537">
        <property type="protein sequence ID" value="KJH43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG47"/>
    <dbReference type="STRING" id="29172.A0A0D8XG47"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000003">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="307" mass="35532" checksum="242804C5D591FDC2" modified="2015-05-27" version="1">MDMQNIVNNLKSTALTVGEMLTPILKQSKFRETGVLTPEEFVVAGDHLVYHCSTWKWSKAADPSRVRSYLPEDKQFLIVRNVPCHKRCRQMEYDPSQEKILSAEEIGAEEGFAGDEDSGWVDTHYFAQDVNEHIKSVELDVNEPEQTICDDDVNEAAMDLDDFVESGGLEDIDPNRYVAPKSHAVAEVERPRTYDLHITYDKYYQVPRLFLMGYNENRKPLTIQETYEDFSADHANKTITVETHPHIECDMPTVHPCRHAEMMKRLLDQLEENGKELEVHEYLLIFLKFVQAVIPTIEYDYTRSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG83</accession>
    <name>A0A0D8XG83_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716835">
        <property type="protein sequence ID" value="KJH41386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG83"/>
    <dbReference type="STRING" id="29172.A0A0D8XG83"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335804" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16353" checksum="75D101FF0D84AE8C" modified="2015-05-27" version="1">MLSLSTVLIHFLISIEVDQAKIPLYCPCILFNTTGVFHSPNYPSKLKNINCLFYHFRAPSESIVQITFNIFSLPTRNPTIYKFYLHVCFLCAIDLILSLLEEEKHKQNNMMTISYLCEKNEYFPQLFPLMPRLIPSIRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGH0</accession>
    <name>A0A0D8XGH0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_10302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716535">
        <property type="protein sequence ID" value="KJH43683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGH0"/>
    <dbReference type="STRING" id="29172.A0A0D8XGH0"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="11">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="551" mass="62370" checksum="0BBBA35C84785BE5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGU8</accession>
    <name>A0A0D8XGU8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716524">
        <property type="protein sequence ID" value="KJH43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGU8"/>
    <dbReference type="STRING" id="29172.A0A0D8XGU8"/>
    <dbReference type="OrthoDB" id="9981668at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="258"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="495"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="842" mass="93958" checksum="288739F4B4CCFAF7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIG4</accession>
    <name>A0A0D8XIG4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716550">
        <property type="protein sequence ID" value="KJH43542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIG4"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
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    </evidence>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="8093" checksum="FD6CDC8382EB83F5" modified="2015-05-27" version="1">MTNNALSVASDGSFGTTAHVQYVLAGDGASTNDVYHLDNGQVLHATPIGQPIPIGSPSSANIDISQLPPGMQIVHIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIL7</accession>
    <name>A0A0D8XIL7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Laminin EGF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_11862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:tissue development"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Laminin/Netrin_ECM"/>
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        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
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        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
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        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="EGFLAMININ"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
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            <end position="154"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIM7</accession>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C3HC4 RING-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="36393" checksum="B87F1C3929F2A23F" modified="2015-05-27" version="1">MDIRWNPCEYDRCLRKLAIAGDVYHTPCQHDLCAQCFDEAVKTNNGQCPVGGCGAPLNEDDELEQCEGPCHGSYEIEKMVALPCCQVYMCQPCAKKWTEGKGTCPPGKCLQKGGTKSKKGKRNSPVIKTPCSGLPDCEGEVLRNFPSEMECEHEVCVNCLAKTLDECEHNNSPPVCPNEACRLPYRCESVLALKALFPERAAYFGRFDLESHYSMEGLKDDSITVCFCEDEENQTPVEFEKGGPLGDLIREIRRVLKIMNTDKVYGYFRRDIDEEKQLEICPKLIQTPVDKIGITKDSLILVDITGIVNNKAKRTTSTTVVSGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIM8</accession>
    <name>A0A0D8XIM8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_10372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716542">
        <property type="protein sequence ID" value="KJH43612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XIM8"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="387" mass="43984" checksum="FDA4336C091984B5" modified="2015-05-27" version="1">MAAVHQMDLVTLSADKVDILSRILPSEEERKLYAERGDDECLSDEDRFMAALCEIERLEHKLSVMRVMADFDESIALLEPQFTHVTAASKCAREATMFHRVLEVILAFGNYMNSGKKGSAYGFRLASLDSLAILKSPVDRSLTLLHMVVESIERSFPELMKFAEQLKFVDKAAGVQWDSVMADMKEIESGFEMARKERQLKGENTPKPLVEFLNNHDERMKHLQEHAKLAKKTYESCIEFYGESARTTPPNDFFSKLSKFIVNFNRCKQENDAREAFEKRQRDEVERRSRATTRTQQHDGMMRELAERVSNGNAAKRQRGKIDSQQMGHGDFEKLMSGLKQTYTVSATSNIPTPSRRKVSASPSPAPRVGPPVAAKTRVVAIERDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIP3</accession>
    <name>A0A0D8XIP3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_09456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716467">
        <property type="protein sequence ID" value="KJH44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIP3"/>
    <dbReference type="STRING" id="29172.A0A0D8XIP3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="19882" checksum="232FA98C0123A035" modified="2015-05-27" version="1">MSIQVHCGTTGSPKGVMITHRNLATMLSIYIRLESTNITPVLDANWNYEKEKLILFLPFYHAYGFGLINLCLLQGCTGITFKYFEPISFCKAIQDYKIHFLAVVPPVLVFLAKHPICKQYDLSSLKLLMCGAAPAGKDICEEISNKYPSIKYIQQGMMKSLQPFIRNSRSSCFAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIW5</accession>
    <name>A0A0D8XIW5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716688">
        <property type="protein sequence ID" value="KJH42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIW5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="398" mass="43681" checksum="BC3065943FD4571C" modified="2015-05-27" version="1">MDKRTIKEEESQRQSPESSGSECSSCYTSPFDGKIHCRFDSYQLSSQLNREANFSSDSTSSVENTSSTNSTASFGDVEEHLAIDQRSQSPLELATFVSATIIFPTQEYGPRTEESCSSTLTVAPMMQLTPSGLLDENRNILDTSFFNIENSHPFSFTTLSPSSSIALQCTSNGSQQFGVPPSAVLRCPSRDRDARSPDTSPELNGEDRVFGKFFVELNSLRKRAPIPVINYSANNSEESVQLASTRNESMSAQVNALHQFQPSGYARRSWSPPSEIVSLLAKKFILRQRNRNRSLLLRTSESDSTTSESNYSDGDAFCDCETSSPEPDDEQNAGNVGGEGYGNVNANFGGMFPHLVWPITNEIDEMSLEEDDTQASSISTSRSFESLDSGFNESGAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIW7</accession>
    <name>A0A0D8XIW7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HRDC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716531">
        <property type="protein sequence ID" value="KJH43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIW7"/>
    <dbReference type="STRING" id="29172.A0A0D8XIW7"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="4">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="732" mass="84130" checksum="B5B175894BE659C1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIY1</accession>
    <name>A0A0D8XIY1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cadherin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716530">
        <property type="protein sequence ID" value="KJH43734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIY1"/>
    <dbReference type="STRING" id="29172.A0A0D8XIY1"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="295"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="543" mass="60997" checksum="A703CEC50DF1D966" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJD1</accession>
    <name>A0A0D8XJD1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="7"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="304" mass="34185" checksum="CDC205CAC8731D3D" modified="2015-05-27" version="1">MVYCRCVVRTFTGHTQGITCVQFDDDRIVSGSSDTTIRIWDLRGSSDVGSLGTMALNGHSATVRCLDLNGNVLASGSNDFSIKIWNVDVNPRWSSIGCRKTMLGHSNYVRCLQMDHEYLISGSYDMHLKLWSLNTGGCVKTFIGHNDAVLCVQYRNQNSLAVSGSADNSIKCWDTRTGRPEMTIHNAHDNAVTCVRFDDQRIVSGSVDRMIKMWDVRTGKCMHTIDWKLAEGHTGVVRCLQVDTWRIVSAADDRTIKVWNVDSLQRLCTLHSHEDGVTCVQFSDRQIVSGSYDKTVKLWDFSRF</sequence>
</entry>
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        </recommendedName>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716495">
        <property type="protein sequence ID" value="KJH44149.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="20867" checksum="2C91536F220A5BE0" modified="2015-05-27" version="1">MFPVRVAVETVRAQHCLSCAHDGHILVDTYAIVSGTTVLSQLVETVLSALGHPQLALNARGLVQVNNWKALPFEQITDNPDETVHSLFKDISGHITLRILTKPSTSDSASTQCITDLKQRLLKTVVSKNPQILNSVDNQQIKELISQVIAGDDPAILNHEQINSINEWLETLDQGDERRRSVFDIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK39</accession>
    <name>A0A0D8XK39_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_09771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716491">
        <property type="protein sequence ID" value="KJH44199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XK39"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
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        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
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        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="PCB-like"/>
    </dbReference>
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        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="182" mass="20680" checksum="01289578335831F7" modified="2015-05-27" version="1">MFVDFVQHFRFLGGQDCPDWLLYQIGEFSKLALCQNSVEFILGNEVPSQDIERFVTEHIETSDVHRLLYSVSYMMKNAASYNCDCKHFEVECSHLGLPPEHSKALARIYAANVDVLKENLRNSISKEPPLECVTLAGGDCTPYLQYVKSGRTTICNLTSGQLSSLRQDMSVIQNTIKMKFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLT6</accession>
    <name>A0A0D8XLT6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716452">
        <property type="protein sequence ID" value="KJH44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLT6"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="194" mass="22278" checksum="3212E795DB1C2A19" modified="2015-05-27" version="1">MALKQRNHSSQIFNNFYENTSSLREPSNNQREFSHKKISGKCEAHVDEKIHKSATICSGDVPKNSVILPTGKPESSYTQNHCTGIIKHQQKQFDPVQRTTCYKNKTTNSVSIKTKPFPNTKEDHSANTASQHEYTFHKGGHYKAKDYSYPENFKTDRHFVKMTMNQNDYVVGKGERYEAKRPKDSEILKGDGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XM91</accession>
    <name>A0A0D8XM91_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716390">
        <property type="protein sequence ID" value="KJH45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XM91"/>
    <dbReference type="STRING" id="29172.A0A0D8XM91"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="305" mass="33821" checksum="5A3F4DF946BCC5BB" modified="2015-05-27" version="1">MLEPAHVTLIVNGDNSSAQVKPANCAVDEFTTPFSVNDVISVNDSDKPNDIHTFYTKKSDSKRRKMNRKIPNNASRLFVPEQRRFSNISGTSVVSCPCAVVEFGDGDDDVNRQAPQHARFSLNLSPAVIHHKSVRIGAPAIGFRPLKAFGRRASQPTLQLDDISPTNAVTEPLNSKDKMKLLTKRVSWLSMKSLQEGDKERIKLGLGGSLSKSGDSRTASQYGSQLQLYSEHDFDSDTPPLDTLSWSNAGDEYDNVTLMYAKHEKIPMKDFGSEIRATMDIDHLLNKAVLLLDLQETSLEEIFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN73</accession>
    <name>A0A0D8XN73_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716524">
        <property type="protein sequence ID" value="KJH43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN73"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF7">
        <property type="entry name" value="BURSICON SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335823" evidence="1">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="44059" checksum="B34F89D64192287D" modified="2015-05-27" version="1">MWVVSLPVVLLFSYSPTLAQVHVRVWQPNTDSSKIKEPSKFRDLAERRPISTATTKPGITTQETINTIITATTSTTTDISTTNTVLSTVQWASPTTVNVCGETDPMALIESLKDSGIYNEIYMAPDIFTASRNFPDLGGRNFMKAKSRYHCDDTCERSSELVRLVMIGDEPTEPPSKESEHSWWSEDQWTRGKRTSFTSTLSRGGRRHELENNLRNLLRELDQIDGDNIQETGKHSEQEEFDRFFASKLHRETVLPTRRKRSSNAELTARNSGLAKDIIGTTIALECRNKYDDHQSGYHLCSSCRAVRHLPRTYFPRILNEVICGESTCVRGDGRCAQRFLPLKNYKQPGSYIAKQTQDIPNVMVMKFRFYITKELTTVQNGAWSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN84</accession>
    <name>A0A0D8XN84_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716418">
        <property type="protein sequence ID" value="KJH45244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN84"/>
    <dbReference type="STRING" id="29172.A0A0D8XN84"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="199" mass="21908" checksum="C0A47900F2AA9588" modified="2015-05-27" version="1">MKVDPRLIGGFDADGYSQVCGAASSKDCALIPAKTPVNVGDDSALESSLSNIYSEASLQVHDPLFRIQRSKIAGEKLDDVHVQSEILRQDLIHDPLNKCENSSNQIEVVHLNDNSKLDYGSVDFCNVYSSVGDMDAHNVHSESGMVVVNGTLEQGHVDADPTTFDQGVEKLDTETDERFLSWLYVSSCMNVFKIQFSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNB9</accession>
    <name>A0A0D8XNB9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716519">
        <property type="protein sequence ID" value="KJH43866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNB9"/>
    <dbReference type="STRING" id="29172.A0A0D8XNB9"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="202" mass="22907" checksum="78F98C402AD32CAB" modified="2015-05-27" version="1">MTASITRMKCSKFTGSLDFLGLNYYSTVVVRRFRGKEKDVRNAIGYDIDGTSYLSKEDMPVGGENSWLRSHPSGLRAVLNFIKDNYNNIEVFITENGCMDTPGEFLNDVTRIRYLREHIAAVSQDSHRSAIVDGCNVVGYTVWSLLDNFEWSAGYTTLFGIHKVDFTSPSRTRTPKESAKFYADVIRNNSVVLIEDCTWNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQC8</accession>
    <name>A0A0D8XQC8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716377">
        <property type="protein sequence ID" value="KJH45957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQC8"/>
    <dbReference type="STRING" id="29172.A0A0D8XQC8"/>
    <dbReference type="OrthoDB" id="5867340at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="252" mass="29097" checksum="D9EACFDFF312D832" modified="2015-05-27" version="1">MVAERLSRSLSFAEKAELLHVQQRHTSSSSLCLADIPPLLSQTQTSKSQVQLVELAPHRFILCIDFIRYQTKTKIFSNYRNELTVYRLLVYVKNMEEKRRVKVARDTSIVMAVDTFITAVLHVWALIQCFQKCRAFYDENSSDEAPIEAMAIHTELDDPVIFTLPRLRRTSDSEIIGTFGKSQKIFTDHHSSMPPPCLPVVYVSNNKKKCLSSLRVKITKETQEHREKNPCKRYVLNKKQYDRGEDMKNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQD4</accession>
    <name>A0A0D8XQD4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_07927</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716374">
        <property type="protein sequence ID" value="KJH46009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XQD4"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000068">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="1092"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1341"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1388"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1501"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1574"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1342"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1403"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH46009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1595" mass="181488" checksum="0AEF22030E8F6E55" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRJ1</accession>
    <name>A0A0D8XRJ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716433">
        <property type="protein sequence ID" value="KJH45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRJ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XRJ1"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RMD1-3"/>
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    </dbReference>
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        <property type="entry name" value="TPR-like"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="288" mass="33244" checksum="0C0FB7FC505F5792" modified="2015-05-27" version="1">MFEKKKHFQKRYVSTAKRLITGGFSLSVALPFFSSTQPVKITEDDTSKPKNFDIIVREADALYDNYLIENAYIILKKWESSVCSELLWRLARVLCEKAKLSEDKKKKTSLMYEAFAVVQKAIENEPKDGCFGAHKWYAILLNYIAEMEGSKSRLQKSREVKEHLERALQICPGDATTWHILGVWHFSFADMGYTTRLVAKALLATPPSSTYEEALRYFLKAEEISPGFYSTNTYYIGETYEKIGDKDSATKYFYHAFNMPVITADDRTIHEKAYQKLRKAGFKDNDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM9</accession>
    <name>A0A0D8XRM9_DICVI</name>
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            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716355">
        <property type="protein sequence ID" value="KJH46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XRM9"/>
    <dbReference type="OrthoDB" id="5839690at2759"/>
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            <end position="26"/>
        </location>
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    <feature type="chain" id="PRO_5002336009" description="C2H2-type domain-containing protein" evidence="2">
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            <begin position="27"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47676" checksum="04BBCD3D67AB9C5E" modified="2015-05-27" version="1">MFSAVHCFVNCTSFLLFYFSSQNCNSDTDNVSGYPFSLTAEEWMWNCEQLAEFARIGNKLCSTGPIGLINFGISDEHVDYDWNMIEKIMCARSMRNIERTKESDLTVWYCCKGTCVDDETPAFTRNSPSSDKENRIGRYSPRRTPRSPQKPLFKTTPQNSNHVTDESACIFPPGVLDRVSGLVCPFTGKLFYNVDELEQHLRCSYPVFEFEKVTCTSSVICFVVSSVISRTQWHKPRLEFGSGKVSSVKETSPQLKPRYGPPEEIPVKRKHDLPKAQMIPFGEMSFVHPTYSQVPGPSSSKIYHSVVEDTCDWKNHLMERNIRDYIDDTPQEKEFMLLHNRFRSKFRHLIVGEKLTLDFYTKFVECCGMEMKKKRIRAHCVARLTRLVQQDKMTPTNMATLTQKLYELGPNDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRQ9</accession>
    <name>A0A0D8XRQ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716350">
        <property type="protein sequence ID" value="KJH46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRQ9"/>
    <dbReference type="OrthoDB" id="5846812at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="729" mass="84135" checksum="E23F5D9CA8997AC7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS66</accession>
    <name>A0A0D8XS66_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCR4-Not complex component, Not1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_08742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CNOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716420">
        <property type="protein sequence ID" value="KJH45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XS66"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="305"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1360"/>
        </location>
    </feature>
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            <begin position="214"/>
            <end position="259"/>
        </location>
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        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025717"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1377" mass="155804" checksum="631DF3143795509A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS85</accession>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716341">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XS85"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="10813" checksum="6AD489B02BED8815" modified="2015-05-27" version="1">MSILRLSSVSDSWQPSMHGMRGWNIVSAPKILIDPVLGVLASTTCLLHIIVNLCRAIRSPVADKQGYQPAVPRIPQPAIPVSVRSHNTYATTTQRLPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS89</accession>
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        <submittedName>
            <fullName evidence="4">SH2 domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">DICVIV_06395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716304">
        <property type="protein sequence ID" value="KJH47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS89"/>
    <dbReference type="STRING" id="29172.A0A0D8XS89"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="188" mass="21057" checksum="517EC3F554C86779" modified="2015-05-27" version="1">MEEDHYDTPWEFLIRPNSVRLSSADAVLFSKRHDATGSVTTDSSQCSPLLHSPSFSNHLVHISNSPVDSKRHSLRADRPKRVDAQNEEETLLEKNIDRIGAEKLLESRGLGDFLLRSRGEGSAALSLRGATGVLHIKLERRGDKWVIGEGPCFRSISSAVHYYRRHPLPIRGSDHLLLNTSLTNTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTB4</accession>
    <name>A0A0D8XTB4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_06048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTB4"/>
    <dbReference type="STRING" id="29172.A0A0D8XTB4"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
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            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="166" mass="19550" checksum="3761929A893F1E59" modified="2015-05-27" version="1">MLNLKKERKVRKEAKFEEGTESEVTNYYDDEETMRLVNAMSNVIGIPVEEIWEAYGGFFIQFTMETGWEDLLRAMASDLEVRDEGFLTSLDSLHHFIDRFVYQTRLSGPSFRCEPQIDGTLILHYYSKRSGLYPIVIGVVREVSRRIYHNEVTMEVQERKQEYFGI</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="224" mass="24967" checksum="7F427C402911D448" modified="2015-05-27" version="1">MWAGEDSTEGKYKGYSANVDCHSRNRRSTSSSKKTRYAKSEVFSKARDVILERNISEGSHNTMTLGKRPMRMKSADISAAKFQHGGVLVLDSRLKGPVKHALENQPTVSLHTLQFDSKLNEIVDIGSDVEIINDKGMTTTVLTEAEPENEKAAADAKNCSSGKKVSFMSDRSFDRYSIEIRNFDDDDDVARQFQGEPQTKTFFGARKAMENKVPETGSMMPRSI</sequence>
</entry>
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    <name>A0A0D8XZU4_DICVI</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="149" mass="17047" checksum="077D84B6A00DB831" modified="2015-05-27" version="1" fragment="single">KSQLLSNQTNITENGLGSKNGNRRTANVRSVGYTDLFVLNKNDLWNALREYPDARKLLLAKGRELLKKDNLLDENAPEEQQTVEELAEQLSNAVKILQTRMARLIAEHTSTETKLNSRIEFLEKQLHRYKALAGKQTSLQMRSKSHEET</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="20311" checksum="3FEA70A35DF380C2" modified="2015-05-27" version="1">MNSNSSMVRIVTEGSYVPWYARRSFPVFCMPCIPTYMGIWPASAGALIPLALILLIVGILLFHCGWAAHLLDESGQVPIKEKNPITVCFFHSRKTVTTTTTTTYEDPESDLAEKRLLESAYIDPVPEVKQGYWQFDEKESWQAVANPYPIQNFAHFQAYFKTLPGATAVLKLSVSNARWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0J5</accession>
    <name>A0A0D8Y0J5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta-like protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0J5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0J5"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000002">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336235" description="Delta-like protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="8">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="22788" checksum="E497AC8A24E353F5" modified="2015-05-27" version="1">MLLLKLIVLITLHLITNANLFNSGTFMIRFSSMKSLQIRYCFTELPYHYPGTSDTECLKSGYMKVMNHTETILELRLSNITSDHMTVAFNISDRNEGERPNEDQLKNLSYRVVIDGSLPTQRIAVTTGLIIDFSTICNRPFYGLMCAQYCVDEVDDHHVCDRNGKKVCLSGWTGSDCTTPLLSLMLSNRLIQFEVDLPTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1V8</accession>
    <name>A0A0D8Y1V8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abnormal cell migration protein 18-like fibronectin type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716214">
        <property type="protein sequence ID" value="KJH50152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1V8"/>
    <dbReference type="OrthoDB" id="5785512at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040282">
        <property type="entry name" value="Mig-18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055119">
        <property type="entry name" value="Mig18_Fn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572:SF7">
        <property type="entry name" value="PROTEIN CBG04538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35572">
        <property type="entry name" value="PROTEIN CBG04538-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23003">
        <property type="entry name" value="Fn1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abnormal cell migration protein 18-like fibronectin type I" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="268" mass="30947" checksum="A7B6C9A12A784B0A" modified="2015-05-27" version="1">MRSLYIYFYMTGVYACIFNGKPHKNGEVWIENDAFEMKCIMESSRSWRTEVLGCVLPDETVLTIDSQMDIGDITWKCEKHIDGQYVRRRMKNEKSSCNGHPYESDWEEDFLKFKCDRGGIKRFMGCVISLATLIEDGEVKTVDGDEMECKKHKNGTITLKSLGKVKNATCMDSKGRLSLQGEEWIEGKFARKRCTQGGKVEINECLAPQPYTIKSMLQLNDTTKKNLNNFIRFVQSKLETANQSAIEIFREYIRTTERQWTTCGKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y205</accession>
    <name>A0A0D8Y205_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y205"/>
    <dbReference type="STRING" id="29172.A0A0D8Y205"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="282" mass="30816" checksum="DC02BD931669F02A" modified="2015-05-27" version="1">MGGKCHEAEIPDNNDFTITYLVPGIGIVLVVGASDVNVVKERLIDAGETPVEIGSVVKKQGSSLINFTNLDIAFDPSRFLSGPKPKVKVGILISGAGSNMEKLVKSSRKPNSHCEVVVVISNKAGAKGLEIARAMGVEAVVIAHTPIREEGDSRITEVLRSRNVELICLAGYMRVLSPSFIQEWPNSIINVHPSILPSFKGSHAIQDALKFGAKVTGCTVHYVDEQIDHGGIIAQRVVPIDDEDDEVSLRAKIQKLEYELYPEVMQKLARMYLQQKNLIKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2D3</accession>
    <name>A0A0D8Y2D3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716209">
        <property type="protein sequence ID" value="KJH50322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5810923at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17886" checksum="6A9D887178754930" modified="2015-05-27" version="1">MSKEGREEKTVLVFVSEYCVVHRERFVKKCHGDVSQEEEIFCKTYPSSCASTVGVIPVVSYCQRYYKHYPMYCSGSKIERELLQFCFAFEQFCLPELTPAVTDEKPQSSLRRCEDVLPEAQRICNPFPHPRDTFNVLRCSNFLSHCKKFVDWS</sequence>
</entry>
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    <accession>A0A0D8Y2V1</accession>
    <name>A0A0D8Y2V1_DICVI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716204">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="EMBL" id="KJH50502.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="18016" checksum="28B5726D1C53CB7C" modified="2015-05-27" version="1">MLDRSVQLNSKSIRRNLRERDGELRYWPSAVRIEAALELVMIVVTFIFYIKSESETCSSSTYDLIISEKYSCPLQKMKEMCCRLSRMYSMAIRTQKMEKETTNNEWKKKLECSTFRRYCRSIEVENANFEYDDTQHIIPSIKLGLGLRLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y399</accession>
    <name>A0A0D8Y399_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DICVIV_03349</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y399"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
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    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="446"/>
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            <begin position="217"/>
            <end position="336"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="482" mass="55884" checksum="B257292CF974F088" modified="2015-05-27" version="1">MSENSDGDFFGIEYMTSNPSQFHLRIEAVEDVKSSKNCKLTVASRLHSDECYTGYDDSRLSGTEYFDKAFFPQIGTNAETAQHDEEQSTDFFEDNFFRRDENIKLYPIFMNSVEIYSLMKFLIKSLYFSQLIIVLIVNALSQAVLKTNSYYFQADFKYSSTIFKFLFQFQYDELSREDTEKTALEKIRSNIVPVWRMSQDELVNLMANRARVAPKCERLCLVKSLDKYQSGVILFATNSAVQSALKEDIENGLVEHVTRCIVRDELEDSPLKITIPLFKTLKNRDFKLQPLTSNSIKKEIFYVESLCRTLQGRKYISCVEVRTRKEIPHQVRAHLAMARCPLIGDPKYSKCSPIPPKLSQHVLDSLNLSSSQARSFTRHFSVECSNTYTCSNASTFCLDAEKTKTTQSTRINIIAVLLYHVTFSKLYLVLSIYCSCNSCCFVVRYFNIHCHYKHRSSFVAFKFIDRFLHEPSFYDDYLCIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3B8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="41"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="339" mass="39390" checksum="2A7A586BD9FAFB76" modified="2015-05-27" version="1">MKLKCAEEELRDQLANKSVEITELRDNLSKANYEYSKLKEEFLEFQESAEHQYCATVKQKCDIIETIAARLEQLESYPGQVISTDSIHGNTVEKERGIVAEGSRTLYDCVSPSLLDAVERAGNISKDVADTVKLMQNTFIPIEIANMHNFSNLDQYEQQPQLSSLPVSWKQGFSYPLLKEESLLKQLINFLDNSKYIYRFLEGCDKQFYECAMLIVDKEKKAICDEKQSVERKFSSEKIKWEVDRENLEQQLCRYRRQAEKIDTMRNEKTSIASELNAAKVQIDQYRLKLRQKSNELEQIIAERDIAVQLADEFKKLDQVSKRDLLLKKYLTGSYVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3I7</accession>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3I7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3I7"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="446" mass="51178" checksum="19017DEB60EA9B87" modified="2015-05-27" version="1">MHDIDGYREEPMTWITGGRVKRLATAQDEPYLFWSASEDKYVREYDTRTNEEKKLIDTKEKRVKSFAVCQGRTELMAVATDEAAVPIYDRRKADKPILTCVNADDRCHGNFTYTTHVSFDEMGTECLVNQGCGPIYLFKLKSDDRPTVLQKIKSIIESDAEVTIYGKHTLAFTVAREQAKVLFDSKKFPEAIDIYSRALTLSAGDYDRSILLANRGMGYLCRRWEGDSYACVRDCVEALLLYPGNSKALWRLTRSLMLLEQWELAQDCIELFKKRFPNDRSIIRLSEQVSTAMDSEHAHLSPVMCDSKNVLDYSERFCGQTNTHTDIKEANFFGSRNQYIVAGSDCGSLLLWERSSGVLVAAWNADQTILNIVQPHPMQFMLATSGIEDVIRFWEPAEEGKESERRISEPWTHFGQRNRYPTDERDIFLRLIGSQMVFPIQLVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3K3</accession>
    <name>A0A0D8Y3K3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_03278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3K3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3K3"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF46">
        <property type="entry name" value="INNEXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="43853" checksum="6E6958979C1DCF49" modified="2015-05-27" version="1">MNVVQGLLSAVSPLPDGDVADRLNYCVTTVGLVLTSAFISGWSFVGSPIQCWFPAYYKGWWMEYALDYCYVQNTYFIPMTDVKVHNAFDFGSHIIEIPSNYTDRDAKQIGYYQWVPFILAAQAVLFYLPVVLWRSIYESSGFKVRAICETCSLHANMDDVTRQKNMKTIAAFLVQMVKFLYALNTIFQFIFLKNMLGVKSYMWGLEVTMDLWQGREWPETGNFPRVTMCDYDVRVLGNLHRHTVQCVLMINMFNEKIFVVLWYWLCMMLVISLYSFIKWTIATATTSISGRALVNSFIQQIDPSVARSEHKRSLLQQFVTEKLRIDGVFLIRLIAANSGEMVTLALLKTLWNDFSEQRGRNLPPYSKPLLLSGKKISESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y402</accession>
    <name>A0A0D8Y402_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716199">
        <property type="protein sequence ID" value="KJH50714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y402"/>
    <dbReference type="STRING" id="29172.A0A0D8Y402"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF141">
        <property type="entry name" value="CARDINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="284" mass="32119" checksum="EE934A6B3CAA1FCF" modified="2015-05-27" version="1">MLEVRKLKSYKRKISLEDAVLDAIVEVTHMFNSSRRDPTVFVTSDKQASEIRKRSFFAQVAERVSYKLPREQLYANRNALDDICPLRYIACSRSKYRSASGICNNVLSPHSGAVLHSFQRALPADYGDEISSWKLSVDKDQLPHPNRIAHMLFRSSKFYSPQNNGLPSTPISALFVQWSRFLYDDMAAIVPYRDTDGKLPSCCPESDHPECAPLYDDNDPHEIMAGLGCQSYVRSQIAPSARCELGTRQQMNMASSFIDAEPIYGNTIEEALEKRTRKNGNIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y460</accession>
    <name>A0A0D8Y460_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_02338</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y460"/>
    <dbReference type="STRING" id="29172.A0A0D8Y460"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="188"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH51505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="390" mass="45294" checksum="8DFF7BCD5FFA8A08" modified="2015-05-27" version="1">MTIQEWNDYKLVWDIREYGNITDVRFPAGRIWKPDVLLYNSVDTNFDSTYPTNMVVYNTGNVHWIPPGIFKISCKIDIEWFPFDEQRCKFKFGSWTYDGFKLDLQPAKNGFDISEYLPNGEWALPCKNEKFYDCCPEPYPDLTFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLRIFFTCCMIVVTASTVFTVYVLNLHYRTPETHEMSALMRTVVLYWLPWVLRMKRPGVKLTYATLPSLVRVKLKSHSESLIRNIKVNEFNTSRSNSLDVERRLHHYMSCSGAINGISSPLTTMQNSQISTSLDLGQQATLLILQRIYNELKVITKRLVETDREQQASNNWKFAAMVVDRLCLYIFTMFILASTVGIFSSAPYLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4B9</accession>
    <name>A0A0D8Y4B9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4B9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4B9"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF120">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR DAF-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266343" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH51042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="23243" checksum="F549674C793C889A" modified="2015-05-27" version="1">MNFIVLFVIFRMVSIQNITSNYFDDHEMMANPPEPIFSDYLEMTSLVLMFIIGAPLNLAAYTQLAERPMTSRLELLKRHLNYSDLLVIFVYVPSRACWLLTYDWRGGDLLCRVVKMMHTVAFQSSSNVIVCIALDRLFSVFSVTRHSPEKANHRIRLMLAGAWTSAFIIAMPQLLVWRNYVPFKHINWSQCLQVSLFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4F7</accession>
    <name>A0A0D8Y4F7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, SP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_04388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716234">
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="10">HannoverDv2000</strain>
        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716177">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="172" mass="19372" checksum="931C5B6D4CE078EC" modified="2015-05-27" version="1">MESTSFKQENVNGDGEEDIVDLCRKLDTKLEEKAKMHNLNALNVKSILHRLIKDPHVLSTLMGIEGDTGDIPSVKVTRSKVKHVAETPKVELKPVPPPRTFLDVQFENEDDDEDYRPEDVISEESDDEEEGTEVHATTESSQVHEKFTATSFDQPSCVVDGLIVWIIYSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6R8</accession>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6R8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6R8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051446">
        <property type="term" value="P:positive regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH51887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="331" mass="37932" checksum="8DACADBA6CF8D233" modified="2015-05-27" version="1">MDRQIAMVPPGEHYSLDDFIKLDKIGEGTYGVVYKGKHKRTNKLVAMKKIRLEGEDEGVPSTAIREISLLKELKHPNVVELEDVIMQENRLYLIFEFLSMDLKRYLDQLPSDKRLPAAECKSYMFQICQAICFAHQRRVIHRDLKPQNLLVDGKGAIKLADFGLARAIGIPVRVYTHEVVTLWYRAPEILLGTQRYSMGVDMWSIGCIFAEMTSKKPLFQGDSEIDELFRLFRTLGTPTEAEWPGVTMLPDYKPTFPKWKGSSLAEKMANFMGPDAIDLLESMLVYDPARRISSRKALHHPYFDDTEWQERLQVDTSSVPAGAYRGELQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7H7</accession>
    <name>A0A0D8Y7H7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7H7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7H7"/>
    <dbReference type="OrthoDB" id="10069766at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032224">
        <property type="term" value="P:positive regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028823">
        <property type="entry name" value="NALCN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141:SF2">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46141">
        <property type="entry name" value="SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="28722" checksum="451A67012CF6EE03" modified="2015-05-27" version="1">MLSYRSVDIRKSLQLEELLQREELEFIIEEEVAKQTIRTWLEHCLRRIRNPQQKESFADTTKYSIPESAGLPSDGFDLPRFRFAHDDFSSTEEIQMSSPMRRKANKNRRSSIPDAFSFQTPIFLHETARKFMHSNSEKKLTAPRPTRHTSPEVTQFVPKRTDTKKLGTTKTLHLNVYDLPDLEEKGEDETFTSPMLKTDWEENYLPYISSQQISVTPNVSAVNSNLRATLVESTQEIALWWQLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7K9</accession>
    <name>A0A0D8Y7K9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y7K9"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336303" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="301" mass="33726" checksum="57F2ACE6019703E1" modified="2015-05-27" version="1">MPSVAIHVLSVALCLSSGFQQGYVASVLNQPYLQIEKYINESWMERTGHPLQRDLLNVFWSLLNVCFPIATIFGQFLAAFLCKELGRRGTALLASVLYIPGVLLCTASKYFHPYFELLYIGRILWSIANGVNSVNATVWIVECAPPEIRGRMAAMQEFFMAVGSLVVQTLGVPLSNDDLWPYIFLPNIVFVLFSIILFAFVHESPQFILEKEGNKDKARKALALYHGVSVNHISIDAELNICEESIAKKKQAAKQKCNNATKAEHDSITVIFMPWKANDPTSRIYRHAAWLGVMVKVVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7U7</accession>
    <name>A0A0D8Y7U7_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">glucuronosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_01771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7U7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7U7"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF5">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE UGT-58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336282" description="glucuronosyltransferase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="401" mass="46036" checksum="F3B78023B58E09A9" modified="2015-05-27" version="1">MHQLLNVLLTMVIGIDSAKVLFMPNILYPMHSYTMKYLADELLHRNHQVTWLEYGPYQTKTSLAKGIRRIFWPVQFGNQIFNDIFVHRNHSTHYQIWDAEFELTNERTTAWLASIRLCDRLLMRSKAKFDEMLHEQYGSVYIYWSMTALRTESAWANQSPSPPSYLPVHGTKLTDDLSFTERTYNLVSYFRSLYNHQVIVLPRIDEIFQKYYSGVAAAFDIERNASINFVNNPPIFDFARPFMPRVNFVGGLHCRNATELGGALRDFVAAASEEDGFVLISTGFTAQWALAPQRIKDIYLSAFRAYPKTRFIWQYNGVPFENNLPLNVFVQSWMPQQDLLGHPKCRVHISHGGMNSVIESVWHGVPVIGVPLTVSGHDNLLRVTARGAGILIPKTDSVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y825</accession>
    <name>A0A0D8Y825_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 48 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y825"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2270"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2322"/>
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    <feature type="domain" description="MPN" evidence="12">
        <location>
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        <location>
            <begin position="2534"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="2992" mass="347293" checksum="00D6617A2539A63B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8W6</accession>
    <name>A0A0D8Y8W6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="16">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_01406</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:173112"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>[4Fe-4S] cluster</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-B family.</text>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="POL2_thumb"/>
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        <property type="entry name" value="Znf-DPOE"/>
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        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
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        <property type="match status" value="1"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="11">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40427" checksum="6FB6D751AB5B542B" modified="2015-05-27" version="1">MTNDLQMTYLYTILHGYPYRPLYDCSNKTVEEWYATGTVQLPLGLYFLITGVILEMLYCPCLAAMVQLKLLNNSCYKLMFFLGFLDMSSIFVNSIMTGYFAIEGTVFCTNPILLITLGAFGCSCWCASCLTCVLLALSRCADLSESKFMKMCFKGNRVYFLIFITVLYLLFIMFFTTPASFNSNYVSWFFNPMNGHEASSYYNIYHTINNIVVSISITLLYIYLCIKFYSKTNSAISKVGRFQKQKKEFLHELTTIIQYIARLLSIQIFIQSFLICFINVIAAYIYVYMQFFSPPKWVVVVGQIAWQLSSGFVCIIYLTINGTIRGGVMRMIFPKKWMDQTFGQTVNSQYV</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <sequence length="341" mass="38635" checksum="BB2EB5AFC466BCC3" modified="2015-05-27" version="1">MYIFRFVNSNHMSTPPEQTESDLSVPLPSCSHGATILDVDVLTKVFEKLATIGNISDAIKLTAISPIATFAFHRSLARHNHIRVDIRAPIEYRIIGLKEHKLPVPEPVIYIQGSRVTPKAALELMEFLINQMKEISEVSLNIEDPDMTTFNLLLDQLINADNVKLKVLRIKRRKGGQTIQKIIKLIEANVDTLQIVGRIGLTEALALNSSVHLERLSLMMFDLGFEVAESAIFDHLLKIASSGTTFRHLSYTGFIGLDPTNDVVQNFLDSCKVKSLRMTMMRGPYIPPQPDYMIGKIKNLDHLELGEVVDKPNIFNSLITYEKVFKKVFPNVEDIHYFQHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5797130at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="171" mass="19191" checksum="9BD28B5CC4292FAD" modified="2015-05-27" version="1">MQCVKNVAEIKFDIEKSVKREGTFDAIRKQAYAIVNSDGFLESLQKKVAVDIRNMVRCNPERLSKEDFRSMIRHHLRTKFLPEITEKVNSSIDRQWLKSQLADNVKEKVEKALMVESVLEGKLSADSFDFGQVVSSVDLSISSDDSCCQGKSSDMSVSDIASNSSFIDVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC17</accession>
    <name>A0A0D8YC17_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
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            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716150">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
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        <property type="entry name" value="TPA1/OFD1_N"/>
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    <dbReference type="InterPro" id="IPR051842">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="458" mass="53550" checksum="A110221C37629ED7" modified="2015-05-27" version="1">MASKRTRWKSSTFVVNPSYNDSTFIHKFRKELTDKDPFPHWQLRDFLHVNPSVLERIEDELINYPLWNRKENDLYSLHQTADLRTINKVKYPAIAEFRRFLYGQMRDWLENISGVELLSQVDATGSCYATTDCLLPHSDQVDGRRFAFVYYFTDEPWEESFGGYTNIYNSNDDCVPTTIFASLRPYRNSLLLFEVSERSWHSVTEVLGKDNNPRLSINGWFHSNRPVGNRVRVLSTLPRFPILNEGNISYIFDHKVVGDEAKIAMRHIFDSEKELLVKNAFQEEFKNKILEELSSAIWAERGPVNKRRMAEYLFEENSNDGVVARFVQDFRSQKMMHFLNDVIGIHYKDAFTTVQILRLTPGCYTILGDEDVEQFEKDGDSYDFWFYFGKSQWSENAGGQVIYIKKNVVEPVLRCPPTVDAVAIVYREKCMVPFIKYVNHLANSDPFYVIVFSIYGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC47</accession>
    <name>A0A0D8YC47_DICVI</name>
    <protein>
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    <gene>
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    <organism evidence="9 10">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YC47"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="169"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="6">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="43233" checksum="8880ED6A7FA83CDB" modified="2015-05-27" version="1">MVEKNESLTEVELALNHLSDELDKFDATWDANMSKVLSSVDLYDRELLSDCTESEMSVTAQMLLEEVASRGEEILTQMLAHHKSLHHAVSQVGKDIDKTTLKNIGGLIRNEKDIERDSKAERLVNGMVCDYLMTCGLTSVAELLVKEAGLSGRIDGYLANRKVIDWIMESLKNQDIAPAIAWLKQNPHSDSKLQYDLLQQHMIALIQDGKRIEALQFGRQLSSFGYEQDTAHVMGAVVLAKDCTDPRYEALFSPLAWPLLESRMSIALAQSDTRFGNVILTGMRAVPILMNLKQVMVSRQDHLFSGEELPVEVKIDEYIHSTFTCPILRQQSTDNNPPMRLTCGHVISREAVNKLCSNHRNNRLKCPYCPEESHQNDAKQVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCP9</accession>
    <name>A0A0D8YCP9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Troponin T family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_01448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716166">
        <property type="protein sequence ID" value="KJH52356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCP9"/>
    <dbReference type="STRING" id="29172.A0A0D8YCP9"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000006">
        <property type="entry name" value="TropoNin T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH52356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="32216" checksum="49F8675506819116" modified="2015-05-27" version="1">MAIMAAKKRQKTDDEGTLEDYRERRKKEREAEEEELRRMKEKQERRRHEREQEEREMAEKKRLEEEQRRKEEENRRIQQEEEKRRREEEKNKRQQQMIGGNFSSIHGGRNFVIPKKSEKNDKFGNIVQAKQEMGMTKDQQEEAKKAFMIAVRNAIPKASEIPASELKSKIKELHQRVCKLESEKYDMEKRHERQQYDLKELNERSRQVARNAGGKKGVNVSDTDGRHPKNAFPCFPGVPPPPCQFEKIIKKYDNEIQDDDEVEDVEEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCU9</accession>
    <name>A0A0D8YCU9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCU9"/>
    <dbReference type="STRING" id="29172.A0A0D8YCU9"/>
    <dbReference type="MEROPS" id="M12.A45"/>
    <dbReference type="OrthoDB" id="7721051at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF880">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005115639" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="54"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="347" mass="39749" checksum="C02CFA5213D67C1E" modified="2015-05-27" version="1">MLLVLQLIVYLNAVELVEARGKPIDIFNNDKNDILQLRGTDKIRTGDVGNKLHSVIFSNSKRKWNLKDINGNTVLPYRITGNFDYYEHSIIKQAMKRIESKTCIRFRERTTERDFIDIQNRRGEGCYTSVGRLFGKNVLMLESNSVSTCLETHIVQHELLHAIGLWHEHMRYDRDQYIKVHYENIKPGYESQFQKVSPLESTVYNIPYDYRSLMHYGKMAFAIPGTITMEALDRKYTNVIGKQRDASSSDYLKVCKAYNCKTCNDEIVNPDEEDDKEPIDPWLPTTTLKPPPVKGCVDMIYGLCSFLIGSGIMSCNSGGTKFCCATCKGGKDGIDLLGFYDDFFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDA8</accession>
    <name>A0A0D8YDA8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calsyntenin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716162">
        <property type="protein sequence ID" value="KJH52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDA8"/>
    <dbReference type="STRING" id="29172.A0A0D8YDA8"/>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF2">
        <property type="entry name" value="CALSYNTENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
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            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="21876" checksum="7A2DD07FCF605568" modified="2015-05-27" version="1">MPSSSESPVSSSVSSTEYFDGLDMLGRHFEPALDQLGSSRLQNILEMDLPRPKALLSHHGYEVGQGAIAGGAVAVVVVLCVGFLLVLLVIGVLKMKDTPLPRKRRCKQQDDGMSWDDSGMNITVNPLGDVEKNVPDEDFSEEDGSDGEDSDGTFREEEASDEEIEREVLPHLDSQRGGLEWDDDAVMTTSTTTNTRSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFD8</accession>
    <name>A0A0D8YFD8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transthyretin-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFD8"/>
    <dbReference type="OrthoDB" id="5805988at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336591" description="Transthyretin-like family protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18580" checksum="B9DE004F5192871F" modified="2015-05-27" version="1">MFTMLLQLMVVVLAWLLPLLSMADQLPVCTRVQACAARVNMFPLIDDDSSGWGSGLIPLYDEAFNSISFDYSQIPETSIYELCECPNNGTCESDKEERNIQLDGIVRLTFCDDVQSQLPLECKGSRGLPRVIGIAHPSGGFLIDVLKLFVKLITIEVFYGFSFCVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFK4</accession>
    <name>A0A0D8YFK4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFK4"/>
    <dbReference type="STRING" id="29172.A0A0D8YFK4"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="319" mass="35786" checksum="1A0015A9F53AFECB" modified="2015-05-27" version="1">MDCSLEYLADLVKEKKDLEMFGDNFQHVDRLLNEEISRVRGALFQTEFVTEPFELPEPVGDVVTITEKIYVPKREYPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKRKEEANRGKPNWEHLDDELHVLLQCEDTENRARIKLRSAMDHVKKLLVPAPEGTDELKRKQLMELAIINGTYRPFHKSGLSSSNRIITPVPLVSPIRAPIFVSPTSSPNSVSGWYNINKKPSNPGYIGTNSQQPFDYSSFMNPNFLESALASFQIANELHLPTFPTATSLVNSFPSLFMNTSANSVAAQDASTTAPALSPTKCF</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2505895at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="83" mass="9734" checksum="6E9CB55829FF4E9D" modified="2015-05-27" version="1">MRKYKAAIQKAHLDHIAIADYIEQIAELEKHKERLTEQLNEETSNAAFLSQHTVEKHKLVLCEQKVRDLDAKLDLEITQKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7X5</accession>
    <name>A0A0D8X7X5_DICVI</name>
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        <name type="common">Bovine lungworm</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717061">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="154" mass="17364" checksum="08ADDD967F7D910B" modified="2015-05-27" version="1">MNSDRSEQRQLFGRECAVSNDVSPTGAQTKKTVINIKETERNTGLSKKPANIIAIVEEELRKIDNSKEDITKQQGTLLYQLRTKVRTQCLDNTLLVVRVIISEGIKSKAQVSAALDYLLTSTIREVSKVIGEHRERLLTEGYTFNTGKLMDMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8C6</accession>
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    <protein>
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    <organism evidence="1 2">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717013">
        <property type="protein sequence ID" value="KJH40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8C6"/>
    <dbReference type="STRING" id="29172.A0A0D8X8C6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14355" checksum="C56FDED53138DBE6" modified="2015-05-27" version="1">MPQITSQLLGNEKIVMNTILFANDRLCITRKCVAVGLLYGPNRRDIESTSSEDVRLKFRKSLRDIQYQAATFLSGCFSAEAAACATSKAANLLLVLPTVLQIEKDDVRLCFFAEKTLTELEEYCVSAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8E1</accession>
    <name>A0A0D8X8E1_DICVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717008">
        <property type="protein sequence ID" value="KJH40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5789202at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="12003" checksum="A1D814123E850AD0" modified="2015-05-27" version="1">MPEKIRVTINLKTVTLTKTNDMNTTGYTGRYVPKWAVWLFAACFLLIVVVLLLDYCVTRRNALGNTCCIRSRQKRNIATAVHQKRSTNMLLNKLNRQGQCADQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8P2</accession>
    <name>A0A0D8X8P2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_13121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        </citation>
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    </dbReference>
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        </source>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17940" checksum="3FDB22C07AE3A4F5" modified="2015-05-27" version="1">MILNAFAFLNTKKNDSTENGLERPHMSLTPTVSNSISEIWAGDHERRLYTKLINEYNKLARPVKNESEPVMVLLGLDFQQILDIDEKHQIMHSNVWLRLSWIDHYLTWDPAEYGNIREVRLPISSIWKPDVLLYNSVDQQFDSTWPVNVVVYL</sequence>
</entry>
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    <accession>A0A0D8X8Z7</accession>
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        <lineage>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716926">
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    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="344" mass="39691" checksum="F9494AB41F3733C0" modified="2015-05-27" version="1">MELEKNRLTTEYEEVIEHHFPILFNIHLALKIYYITFQAKDAQIRQLLSELERKSAEIARLQCDPESEAVRKSIATEIRSELEKESKNRLDLLTKGILQKKDEVIAKIKKEMQYELKLSQQEYNFSMKWLEVERDRLKEYIISNSSEGRAFCDTVESDIKSAINSSGEVFRLVYGTSIATQTDSINPLTEVEKGCTSQLGEMKESTFAIERLPELIESTILHEDALCSNSQLNDAHVQTKISLKSMCRMISIEDIGVGSTVLVIWNNEHKAYMLFSLSVYSYFVKESSVLRLGLSTTHPDVPRREWIIGKVSQLEFCIIRKANNRYHLPVDTKVYRVDIKPLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9I3</accession>
    <name>A0A0D8X9I3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UNCOORDINATED PROTEIN 58"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="47"/>
            <end position="65"/>
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            <end position="95"/>
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        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41218.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="182" mass="20909" checksum="D1A287D411495348" modified="2015-05-27" version="1">MNDWVLHQRENTAREWMLSVSEVVDDRRPIRRELNRPDDLANMHNKWTFPTALLYVLTVLTTCGYGEVSVDTDVGKVFAVVFALVGIPLMFITAADIGKFLSETLLKFVSNWNRMTRKIKQWIYRSRSGRRKSIQSSNDNTDTLDILGGGGTEEKLWFPICEYCSLFFFTSPNFIPPVKCSS</sequence>
</entry>
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    <accession>A0A0D8X9M3</accession>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="KJH40472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="141" mass="15549" checksum="5735FE5792F89C8C" modified="2015-05-27" version="1">MADGYDLYEPLGDQNNVVDAPPQAFPSPPKPNQAMLRNIPTAVEPKSLSLIDHFSENSGRKKKNARIKQNRKGRKGRATNKSAKSEKNSSSSKKQLSGCMLFTMAAVLIVLTVFLASTIMVALHVFDVLHSIPQLNKYYCS</sequence>
</entry>
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    <accession>A0A0D8XA44</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="111" mass="12826" checksum="368693A54E09DDC8" modified="2015-05-27" version="1">MWKEFDLKFDGNQYRGYALVLSDCVWFWVGLKNLTSLGLALFPMSSMLIDTPNTQNVCVKAITTRIAKLFQGKQVFFSSDIDEEDPLFWQHMFTALQPQFNSISSIMTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAC7</accession>
    <name>A0A0D8XAC7_DICVI</name>
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            <fullName evidence="4">Calcium-dependent secretion activator</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="301" mass="35034" checksum="30E22DF9DE7B25E4" modified="2015-05-27" version="1" fragment="single">DNDYENEVPTQLVSDEPTLSKEEQERIRAEREEEEHKKNLQMYVFVARCIAYHFNAKQPTDMARRQLKVTKHDLARMKERFQAFLKGETNIATDEAFAKAMHSYCEVFLKSERVQKVVAAGGFSMHDFREVFRCNVEKRIRSLPEIEGLSKDTVLNSWMTKFDTITKGDDEAQGRTSRGRTRNVSNQPNADLILGKEQLYDMFQQVLTVKKFEHQIIFNALQLDNPDEQAAAIRREVTTREEACKDIHKMRKIMPKFVVKDMETLFMDEVRQSINLLISNLESVPVTPRGQAVGKRKEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAU9</accession>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716771">
        <property type="protein sequence ID" value="KJH41725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2132119at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Liprin"/>
    </dbReference>
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        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Liprin-alpha CC2" evidence="4">
        <location>
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            <begin position="409"/>
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        <location>
            <begin position="796"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH41725.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="877" mass="99844" checksum="1B7193C0057B5FC8" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBF0</accession>
    <name>A0A0D8XBF0_DICVI</name>
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        <recommendedName>
            <fullName evidence="14">Golgi-associated PDZ and coiled-coil motif-containing protein</fullName>
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        <alternativeName>
            <fullName evidence="15">CFTR-associated ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">PDZ protein interacting specifically with TC10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_13053</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716942">
        <property type="protein sequence ID" value="KJH40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBF0"/>
    <dbReference type="STRING" id="29172.A0A0D8XBF0"/>
    <dbReference type="OrthoDB" id="10063653at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06800">
        <property type="entry name" value="PDZ_GOPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000067">
        <property type="entry name" value="Golgi-associated PDZ and coiled-coil motif-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038879">
        <property type="entry name" value="GOPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16528:SF2">
        <property type="entry name" value="GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="18">
        <location>
            <begin position="182"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="289" mass="32463" checksum="28336C73AAC660C5" modified="2015-05-27" version="1">MTGDEPTFLYAASVHRLQCDLYSKTAPHESDMIKKKLKITVNRYCTKKICKLENQIVQLHEVLMPSLRSECELDVLRKECARQRHLIGALENEVFGARLAAKYLDKELAGRIQQIQLLGRNMRGVEHDRLWNQLEAEIHLHRHKTVIRACRGRGQTKGLPTPPNVECTKSTKRKRGVGETRKVLLAKEPHEGLGISITGGAEHALPIVISEIQPGQPAHRSGQIYVGDAILSVNGYDLRNAKHQTAVDILSSQQGDLHMEVVYVAPEVDSDDEGTVLIEDADGRIYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBG6</accession>
    <name>A0A0D8XBG6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720317">
        <property type="protein sequence ID" value="KJH39806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBG6"/>
    <dbReference type="STRING" id="29172.A0A0D8XBG6"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="49" mass="5605" checksum="FED5C0D1882EE7D3" modified="2015-05-27" version="1">MQFEGDYQPLPFTLNGMESIMDLWILSRAAYAINRCNTSLEAFNFTQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBT9</accession>
    <name>A0A0D8XBT9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716716">
        <property type="protein sequence ID" value="KJH42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XBT9"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF20">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49181" checksum="360FB438C08F195B" modified="2015-05-27" version="1">MRRDLLVILQLGLAFFLVFSAFNSQGFIEIPVLRKLSQYNPSSGITQLSGYYSLATIYFVFTICNLVAPPVISLFGSKWAQVLGAVCYTLFMIQFLFLNAYTLYFFSALLGFGSAMIWTANGAYLVQFSRQGKITRNTGVLWAMLQSSLVAGAIFLFFVLNDGDLLSCYRLIYTVFAIVSIAGIVVFCLLPASPPLGLEETLQEPLFDENVDELDISSSSITFAPSCWREEFRRTFSLLVTKEVIILSVCFAFTGIETTFYTGVYTSCISASVVLNMGSEKIISYVVLAMGVGQISGGLLFGLFPRKNSLNRSQVVTLGMILHITAFFLCFLNLPMESPLRKTSAIGYIEPSIFMAILCGYFLGLADSCWITQIYALIGVMFKHESSCAFALFKFFQSFAAGASFYYSSILLLHWQLLFLCLGAAMAAVCFNVVSTQAELLEDGD</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <source>
            <strain evidence="4">HannoverDv2000</strain>
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        <location>
            <begin position="212"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    </evidence>
    <sequence length="231" mass="26177" checksum="F7BCFE180FCC5AB2" modified="2015-05-27" version="1">MLFTLTLHVIIPQCFQTTSEQGMVWYARSRNRARHVIVLLSPTTTTLCALFKAKRKRTSRPGFIVLWCMSGSFPIYETYTDCVEECGLLVSQCVGTAPFIVCQLNIVVFLVCIILAVSTGILIPVICILCYISNWCTDMKRFWQFGRSTDDEAVRLHPRTLQVTLSDCGTPVASSYVGRFTTTGQRTNTDAPGASQHRREDYLAEKLRDHFEHEGQRRHVDEQSVSSKNET</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </reference>
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    </feature>
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            <dbReference type="PROSITE" id="PS50948"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A0D8XCT0</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="158" mass="18433" checksum="5DA3CDDEC547C306" modified="2015-05-27" version="1">MAKLSERYRSDPGIPYTRNFLGILESSMSPLFCTVSKFYSIKMRWLHMNEKIATLAQYSYKKPMAFSKYFVIYNTNRQNKDEVVSVLTSSIHRPSRLTRAQSHGMDAAVRHSYGYKRREILAKTTSKDNSAIKGTLNELFMYDWNRMDINVTGVHEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCX6</accession>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Hallsworth Pepin K."/>
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            <dbReference type="EMBL" id="KJH41867.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDM6</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="6">
            <text>[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11268"/>
            <dbReference type="Rhea" id="RHEA-COMP:11269"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.20"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer or homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Alpha-type protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.20" evidence="6"/>
    <dbReference type="EMBL" id="KN716636">
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    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:elongation factor-2 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to differentiation-inducing factor 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Sel1-like"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
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            <end position="340"/>
        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="PIRNR" id="PIRNR038139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="765" mass="87054" checksum="08DF4905C529F781" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XEF0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717013">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="87" mass="9784" checksum="B673ADD5499DD6E1" modified="2015-05-27" version="1">MNRTGAKGFIRGCYSSLFLDGFNRTGSAGALATHSFCHTFNLTQLLSRGHPQESTMSDNYIDRRDEDDIFVIMCEAYELKFPPPDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFI8</accession>
    <name>A0A0D8XFI8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716660">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJH42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="240" mass="27866" checksum="6A83627193A024EF" modified="2015-05-27" version="1">MIDEAEDVEGGQQKELYIFAEHAYLPKDRSTTIQSKEEHITVRDALTQNYRVYRKIKDEHYLDQPHCEDAPLAIRHPFVLMENCLHNELKGSVSCPDYSSSKSPNPLILMISLCGGLSYRSATQCTHTLCENYWQYYWQFPQWLKLFKGQWAMDISIISESLKHLKPYSAPAKQIEVVIITHYKNTGSLTSMYKPLPLSHNEIATNASRASTMRLRQHKIIQKYLRQYAKPPRSSLEVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XI75</accession>
    <name>A0A0D8XI75_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_11986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716721">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="4">HannoverDv2000</strain>
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            <authorList>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="3">HannoverDv2000</strain>
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            <begin position="53"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    <sequence length="164" mass="18661" checksum="1DFA596DFDDD995D" modified="2015-05-27" version="1">MSLQLKRITRRPQRYECDTYSTLSRKQDILAQRRAASLVGEPKINKNITRCSSSSLADNANNSQSTTHKVIQKNTKKVSKPRNNTRKSSKNLAHGAKCWNFCDCVLIEMLRAQPFVELCERKGKRIQFTINPDEAVNLSSTKEKQTKTKKRKTHDSTDGSSTEC</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
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</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="14949" checksum="7440B4CD24868A8E" modified="2015-05-27" version="1">MNGLYLTLFVVVLFINEGSSKPGVLDKPCEVCQVVLNGVKTALSNAPKISEDVIDLCIESACMTHGPLALKICQLMDRKYLHQLFISVMKEEKELNTKEACVELKLCFDVPQIPNLNNLPQIPKLSKITNIFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKY4</accession>
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        <submittedName>
            <fullName evidence="8">Peptidase, M23 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">DICVIV_09556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LECT2/MIM-1 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M23_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
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    </dbReference>
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        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008663">
        <property type="entry name" value="LECT2"/>
    </dbReference>
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        <property type="entry name" value="M23ase_b-sheet_dom"/>
    </dbReference>
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        <property type="entry name" value="LEUKOCYTE CELL-DERIVED CHEMOTAXIN 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="37177" checksum="699F297B80D4A6D0" modified="2015-05-27" version="1">MLFYLAILFALISVVNGLGCMVKVCGGNEKNEFRRCPDSDGTCGNYHSERSSGEIVDGVDIRCPNNSPVYAPFDGEMFSWRPFGGAADKACADNGTRIEGTGQWQGYAVHLSSVKLEFFGGKVKAGDELGKAIDRGCYENSAQKRAEPYVELKLYREGKLIDPTYHLQNCMCTGQICESNPKNKLIGEPFKSDKRFNGVRGWEIECRMIEDEYGGEKRAPMVLSPIDGELLGRTRLVFDQNGAYSGCDNDGMFIVGTGEWIGFEVRLYNVKTREDLGFGRKRIVQGEPIGSKLVCDNSPESIFVEVRYQGRVVDISDMITAEKCQLPQLPDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL05</accession>
    <name>A0A0D8XL05_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
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            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="155" mass="17916" checksum="88924DDB006C4ED6" modified="2015-05-27" version="1">MDGRYAHTNEQMTIHNMMKTNHGLTPTPFVTSFLPSFHFGVKRKRRHRTIFSEEQLQVLESTFTETHYPDVSLREKLAIQCDLKEERVEVWFKNRRAKERKQKRESGKDGGTAQKTVSDESDCDLSDDDETMQTKRAKIARTLPSASPIDKTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL45</accession>
    <name>A0A0D8XL45_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716596">
        <property type="protein sequence ID" value="KJH43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL45"/>
    <dbReference type="OrthoDB" id="5835752at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36939">
        <property type="entry name" value="PROTEIN CBG03389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36939:SF1">
        <property type="entry name" value="UPAR_LY6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="250" mass="27716" checksum="2FAC682ACCB71E17" modified="2015-05-27" version="1">MSYFYKLDDYGCMGVSIESVRGIAMPKCASESLFSRWQITGLQRIQDGYFTDCSAQNLGKLQTESCAGDCFVYMFEDPDIFQSQGAASVMLVVRGCHTSITTVVSNRTKSQYGESYCEHDASHQMSNSKGEQVTVRALIIGGEVLKCYECNPQEGVNCEDKDRSCSSKKYCSKQTIHFGGGFQILKSCTNINILGVDNACVTYNVLSSPGGMTIRNKYSQCYCRDKQFCNTVSSSKLVFAIFITISVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL75</accession>
    <name>A0A0D8XL75_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_08550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716410">
        <property type="protein sequence ID" value="KJH45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XL75"/>
    <dbReference type="STRING" id="29172.A0A0D8XL75"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15637" checksum="ACDB2FE68FC523DE" modified="2015-05-27" version="1">MHPYLSYMVERLVSSDIDSKLKNSFAIEEEGFDHYEGEESNNLIEEFVQYVKTSKIVNMDELGSRFGLKSEETVSRLHYFLENGLLEGVMDDRGKFIYITDDELNAVAKFINQRGRITIHELAEYSNKLIRLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLX1</accession>
    <name>A0A0D8XLX1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716453">
        <property type="protein sequence ID" value="KJH44732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLX1"/>
    <dbReference type="OrthoDB" id="10620020at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="217" mass="24448" checksum="6E9ED1D6CB569271" modified="2015-05-27" version="1">MFIYFIAFVEGTCIGRRCYKNQTHRGCTDDIGCRLLNIEVDCTHSPYPCCCKRNLCNEDMTEIKEDGVDTPSNEYWPQILVLGLAGVGFVIFISILLMKKNSKRWKSKRSSSSQRSVSSQSDEKSIVKSRKNSNSVDKSPSPIWEDDGIINHVDRTHIKVEAVISSRTKKLLKEHLVSGPPALENHKSFDQSPKITKIVTYGTSDHITLLESPPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMK2</accession>
    <name>A0A0D8XMK2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716389">
        <property type="protein sequence ID" value="KJH45745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMK2"/>
    <dbReference type="OrthoDB" id="6093641at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="291" mass="33525" checksum="2F780E75DBFFFC39" modified="2015-05-27" version="1">MQLHNSKLLPEYYYTFGEVIDETPPRYLNDEIDSFSSLRLLHSLTEMIFIDSFSVMRLALLIFIKMSSVSVFARRLIHWTTSVSFASLITVQTLIYNVPSLRKQSSFGSFAEYIPGYNKRAFDTLAAPGFIAFDKRAFDSLEFIGTLDSLKKGLKLIEGPIKNLSILSQRLIIKQSLMFLNRLRVSFSHLQIYTIHSKTQKYAGQGFGAFNKRALYDLIDESNILEEPSRHAPNNEIDPRHRAVPLSMLSIVTQTLEGRIPAVFSSLKISGLRRERRNRKYVHVKFHRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMM8</accession>
    <name>A0A0D8XMM8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716430">
        <property type="protein sequence ID" value="KJH45059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMM8"/>
    <dbReference type="STRING" id="29172.A0A0D8XMM8"/>
    <dbReference type="OrthoDB" id="8947034at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="262" mass="28585" checksum="608E55ED37AE4C17" modified="2015-05-27" version="1">MQGSGPSLQHKYQAGPSSSSQMVPCGSPCSMQNNVSSQQVPSLHTMVGVAPQPNHPSCMQSVNVQSPLQSPMNYQLQNYGYPNNSPMQSPLGSPLSSCLMLEERMTPMMELSPPNVHDPCSESASLPNLQHQTFPPHQQPPQFYHQTIGQRHSTSGAIITTPRLTPAAAQTSESQSAPTSPANNLDPSQHLQWSEMRTFSNSPESLDIPRLVLTNPEGANRPHMECFNEQHLELGANNMQMLCNGVTNGSPLNQVYEEFSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMT6</accession>
    <name>A0A0D8XMT6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L1p/L10e family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716383">
        <property type="protein sequence ID" value="KJH45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XMT6"/>
    <dbReference type="STRING" id="29172.A0A0D8XMT6"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57033" checksum="68B98F58490D0E5E" modified="2015-05-27" version="1">MAINAEHTYRKCVPRKRKARASNQTACGAKKEIASDDLENSVNTKEEISEKRKDETLAFVPEDVTEKGRRALGALKNYVADKSNKSLFPDIDHAVGLTILYKKPALVSKKARLRIVLPASHRTPSNTSVCIIMPDLDQSAEARKDPDVDKQARQWAEKIEKDHGLTNQHYAKVVLIITKRQLEREYHTYTQRRALATMYDLFLVDARVGRTVRSFLGKDFYKVHKEPLDFKYTKPLVTAIEQAVKTTIMKLHRYATRINNCFHCRHVSFGHLGQDLEALGRNFDEVISAVINNCPGGFNNIRSIYLQLVGSTPSLPVYFDNVVLERPKKRRRGVEEVCDECSTLPDGLKLAVRRDGKIRVLKENTGASVYYPTVHDEWEERDSLKPTIDPEKLKRKRAIKKKQSIKRKIQKKIKLGELVVVRPERAKSSKLFNEYPMVLLGETNAVAFVELPYVCRIKLENLHSCKSQGFGRQIVNNSGHSEFQQPKALIAPMGLKIFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN69</accession>
    <name>A0A0D8XN69_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_10158</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="KN716524">
        <property type="protein sequence ID" value="KJH43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN69"/>
    <dbReference type="STRING" id="29172.A0A0D8XN69"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="316" mass="36099" checksum="594A5467F9874F2E" modified="2015-05-27" version="1">MSREATKRYETIKHLGEGQFANVYKAKDKESGDFVAIKKIKLGSRAEAKDGINRTALREIKLLQEIHHDNIIGLRDVIGSRTNIQLVFDFMETDLEHVVKDRDIILMPSHIKNMAMQTLLGLEFLHVHWILHRDLKPNNLLMNSAGRIKLADFGLARFFGSPNKIYTHQVVTRWYRAPELIWGARAYGVGVDMWAIGCIIAELLLRVPIFPGESDLDQLVKIGHVLGTPTVEDWPAMVKLPDYIEMKVSAAKVGYFREQQGINLRHVFTAAGDDLIELLQGCFAYDPLKRFTASEALQCPYFRQFLLNLPADYFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNI3</accession>
    <name>A0A0D8XNI3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9841" checksum="F2E10E4EE272D8F9" modified="2015-05-27" version="1">MSSSCPIDGVVFCDAAPDTNPSRMQIEFFNLAGNVVRTFNNTGTTLTANVYCRDGKWTVISNDRYVEISSVSCAQDGSMGADRGYAIGSAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNI9</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
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            <strain evidence="8 9">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="320"/>
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            <end position="68"/>
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            <end position="123"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00010883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="548" mass="63480" checksum="7BDA91AB909B1C45" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNM0</accession>
    <name>A0A0D8XNM0_DICVI</name>
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        <submittedName>
            <fullName evidence="4">Transporter, major facilitator family protein</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="384"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="3">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH43976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNT4</accession>
    <name>A0A0D8XNT4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_08503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716407">
        <property type="protein sequence ID" value="KJH45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNT4"/>
    <dbReference type="STRING" id="29172.A0A0D8XNT4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="21727" checksum="C76E4DC961B63216" modified="2015-05-27" version="1">MSNQASIAPHTPDIPAWIIKMAETERCYEKAKQEAAVELERCRAHIRREFEQRRKQRENSYRAEMDALKHKFDKRLKELEQVQTDLAVNKFRRLSMDQSIRSREEREKKIREMNESSKQVFNTERKRFSIGIEQLLEQKQQEHRDEMNKLAMQEAKAMQRLEEIVAIIQEDDRRVRPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNU0</accession>
    <name>A0A0D8XNU0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716360">
        <property type="protein sequence ID" value="KJH46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XNU0"/>
    <dbReference type="OrthoDB" id="5857071at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="138" mass="15815" checksum="416B4726262D58C1" modified="2015-05-27" version="1">MIDAVIFWHLLYPFQIIIGERYGYGFSASGFSGYDYPTGGSGIVFSNVAAQNIANNCECPTEDSPDDMIIGVCARQKDTVIIHNSAFHQARHIDYPEPYLRKVQPISFHKFEDIDPHSVYMMYLHEPSVNFKKYKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNX3</accession>
    <name>A0A0D8XNX3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="14">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_07735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="14"/>
    <dbReference type="EMBL" id="KN716364">
        <property type="protein sequence ID" value="KJH46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNX3"/>
    <dbReference type="STRING" id="29172.A0A0D8XNX3"/>
    <dbReference type="OrthoDB" id="532682at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="17">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="406" mass="45873" checksum="84553D29B4D64DB6" modified="2015-05-27" version="1">MSVIDSHCLQDVDVVEHDDLVEVLSAGPRAVSSGEQSLDGSIDEERGALSDSDVNCVARTNTLASQVKGPSSDALEESCRMEAVARERGFEWEDLLGSGQLMKRVVKDGKGEERPTDGQWVTIKVVDTLRGVDSHDRLTFILGFSMVIDAWELTAKLMCIEEVAEIRVKPRLAYGENGLDDLIPPNQDQEYRIELLHIGEAPKYTSMGEEELSDFVLMLKDRGNFYFNRREYEKAIFVYKRASGIIEVPKESEALSKLFSALHSNLAVCYSKLEDWNEVLKCTEESLRLHAANTKALFRRAAALAARNDTEEAMECLLQAREIDPHDTIVQCEIERLSGIRRRRRAEERALYRKMLVGVGDINSPSRRFDFVTYRLIAIGAFSLVTFALFVFFLHQLWSLPGDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP08</accession>
    <name>A0A0D8XP08_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketodihydrosphingosine reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716356">
        <property type="protein sequence ID" value="KJH46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP08"/>
    <dbReference type="STRING" id="29172.A0A0D8XP08"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="21356" checksum="4CF24F9AED7C1831" modified="2015-05-27" version="1">MVYATRCVVNEMKSRRSGHISFVSSAAGQCSLWGYTAYSPTKFAIRGFADAIQMELLPFNVSVSVLYPPNTDTEGFKMELRTMPEEVRLITETAGTFTSEEVANAHVKDIECGHYATTIGLEGWMLSILTAGGSPERCMFRVLSQVVLAGMFRGVILVYLGYFNRVVKNCHDRKIVGEQLIKSEEMFSYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPX0</accession>
    <name>A0A0D8XPX0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716341">
        <property type="protein sequence ID" value="KJH46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPX0"/>
    <dbReference type="STRING" id="29172.A0A0D8XPX0"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="436" mass="48588" checksum="6BDEF54ACEBDCC4F" modified="2015-05-27" version="1">MNERSSTCDSIEKGDYVVIQKVGGEHIRVMQLVSKQKVLIEKLRFDADSVFGHPYGLFEISSGKSVPMCAPQIVMDDELRGVNGGGSESIIPIESNKDLNPAQKLQKLTQEDVLSLKGQGITAGQLVSMLVEGNKSFSTRTEYGKSKYIRRKTKKHSDRVLILKPTIRLLARSYYMKDCTRVSNLRVDQLGMILQLAGVHYGKNVLVFDQVLGLVSAAVIDRLGGNGSCIHLHRGLIAQSIPCVHSMNFNDKIFSTFLPVRIASVLGGETQKYEHKCESVSTYKDDIKVDEEDKDDSSELRKADRLAREMRGLTLLEVVGVDALIIATKTVDPVSVLEAVFEKLRPCGAIVIYGSVMEPVLEAYRWLMDHSCVNVRLSDQLFRIQQVLPDRTRPLMAQFVAGGQLLSGIKVIPTVNHINFCVNAIFMWKYQLSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ24</accession>
    <name>A0A0D8XQ24_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716383">
        <property type="protein sequence ID" value="KJH45842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ24"/>
    <dbReference type="STRING" id="29172.A0A0D8XQ24"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF25">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="96"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="636" mass="73532" checksum="B58900B79BF9E150" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQT7</accession>
    <name>A0A0D8XQT7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="66"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="82" mass="9620" checksum="BC77CE1A0A5F51E6" modified="2015-05-27" version="1">MFSVLAGNRRKTLSILKCLRDTHLDFPGTPITNYILKTLILYECEKHCNDFEWEDNCIGDRVIDLGDENLSLEDNSQRDEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XS36_DICVI</name>
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            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06440</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJH47453.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="185" mass="21202" checksum="538280051A6A568B" modified="2015-05-27" version="1">MEVTIQRASVEFISLVADFKLICDDANKVKWIKVIQASGSLIGSIIGGHMGDHLGRKTIFFTGQLFIVITSIMSIASRNWIAYSIIQGINCFLYGVIEVTSLTLMMEYTNNKWSYKRDHLQICSAHKDDFLYLIITRNELMVHYENNKRHSYELLVDKRSSSSIETNVTSLKDYALDSVKWPEHT</sequence>
</entry>
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    <accession>A0A0D8XT08</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716403">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XT08"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="164" mass="19100" checksum="FB442D6B7D2C235A" modified="2015-05-27" version="1">MCRQNEQSSKNFGNFTKLYLPNINKEHAEVNKRNETNAAFLEKKAAKNEKVKSLIDQALRPTKWRETSPGSWMVVASHLRRGHASLNKYGAIAYAISTTYYLRYHFFGRLAEELPVLMNTKIFLIFLKDPPTISHICRDIGDWYQTITDEQFIHCRKRDISSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTA3</accession>
    <name>A0A0D8XTA3_DICVI</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat striatin family.</text>
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        <property type="protein sequence ID" value="KJH47052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Striatin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="striatin isoform X1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
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            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="578"/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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        </source>
    </evidence>
    <sequence length="183" mass="20856" checksum="334425D3FD0EE176" modified="2015-05-27" version="1">MVQAEQSSDEEMDTKPSSLEAAALARKKRLLEMKSRLHGIEMREEDYEEEAEKTKKSQTEATFRSYKPLSEVPGKVAHTIPKFDVVEEDAKSVKPVETVDLSTLAPKKIDWDLKRDIEKRLQKLERRTQKCIAELIRKRLAEGKGDLASTVNAGPMDNCAYLLMSDYGMFCQYVIHGENDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XW37</accession>
    <name>A0A0D8XW37_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716283">
        <property type="protein sequence ID" value="KJH48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XW37"/>
    <dbReference type="STRING" id="29172.A0A0D8XW37"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="363" mass="42345" checksum="DB7A4C9D38E113B3" modified="2015-05-27" version="1">MVACIGPASYNYEETLGTLRYANRAKNIKNKPKINEDPKDAMLREFQVDYDETRGEEYFNEQQRKIAADRESVLRDSTLIVEERRRIIDDLEERQRQLEREQEAQRQVAETIAKMESKLIGGTDLLDHTRQQQAELEHRRRELAEQKKREREILQQLERQEDDTAEIHQTYSSLQQEVEAKTRKLKKLHIKLQKARNELHDADLLHSQERQDMESSVTEINKELKLKLLIVENFIPPDLAKKIRERAQWNDDEQQWFLPGARPLSASRPPTDPLANVLLFDGQDLLTHSISDSGVCSTDASTSMEQNQYLDKRPRESVLSERQEEKSLVIDALKSAPSMKNHLESPLKSIRLSHLNTFFLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX64</accession>
    <name>A0A0D8XX64_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ufm1-specific protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Odorant response abnormal protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_04658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with odr-4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX64"/>
    <dbReference type="STRING" id="29172.A0A0D8XX64"/>
    <dbReference type="MEROPS" id="C78.A03"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000001">
        <property type="entry name" value="Probable Ufm1-specific protease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054308">
        <property type="entry name" value="UFSP_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22084">
        <property type="entry name" value="UfSP_MPN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UFSP N-terminal MPN" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="11">
        <location>
            <begin position="285"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH49218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="478" mass="53914" checksum="2F4A63890230DB25" modified="2015-05-27" version="1">MSADVELVGNFCVEGVSVPFIGSGFTLNATREILENADSTTFLSRNEILRHGNLVPDGLSLRTQVKFTCALRSGCESEDLISAAENFTAKLDQIAFACIDKRILLRNGMDEKSLNSYPFNEFSRGSLQHKVNMPINAISDQKMVPLVRITRDETMYSRLSTTLEVIVPAVFGDNSYVLYNRLIEGVRRKIHSMVYVMLDGFKNQKKLLPPISQVFFPPGWSSLLHLQILNCEESEQHSLRVKFHKLLNLSLSVPCIRCAQAITFAPTSILRSPHLYITSYKPRSKVSVVKGDYFYYHYMQGGVNDTGWGCAYRSLQSIWSWFNLNGFTDKPVPTHLEIQQCLVDIKDKKREFLGSRQWIGSTEIGYVLDHLLGIQSHYIVTNSGIEVLERARELAVHFEVVGTPVMIGGAQLAHTILGVDFDQDSGDCNFLVLDPHYTGSEDLKAVLEKGYCAWKAASFWNPAYFYNMILPQIPKIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX83</accession>
    <name>A0A0D8XX83_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716326">
        <property type="protein sequence ID" value="KJH46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX83"/>
    <dbReference type="STRING" id="29172.A0A0D8XX83"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
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        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="7">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="350" mass="40128" checksum="85D183A476E5C793" modified="2015-05-27" version="1">MTEIQRACYESDEEGLCSPSPTETIRVSPLQISKPEVKESEADYGDFVLDRTESIDLYVEDVVRESSPSVEKSFRYHSDVGPSAKKFRAGRISDELRNALGIGKHDIPEYIYRMRKMGFINGYPPGYLKKAIERDDSNNVLQFHMLDDKVSSTDVLERADSPPPRINAEKMIYYCGFNQSYRDLRDRENFRIPPFLEFVAFHQDILNEKHARKLEARRRMHRREIKIVRKARIELSKDEVVILDPPPPPPPPSMLNNSSDEDIIIIDCESRKTPSPSQSSKVLKGSSIGIMMGTPVLTRRRLDEEAEVDEQKPSLDKFSKGIVPFEAREEQTPHKGFLKKIMGKIKKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXI5</accession>
    <name>A0A0D8XXI5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716264">
        <property type="protein sequence ID" value="KJH48542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXI5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="8075" checksum="916F196C7F46FE32" modified="2015-05-27" version="1">MRVVSVLRWIREEPKRKQGARLTNNSEDSAYPSNHRQSHKGQFRNQDCPTRKTSRDSGVDESEAQRGDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXR6</accession>
    <name>A0A0D8XXR6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_06797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716319">
        <property type="protein sequence ID" value="KJH47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XXR6"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="407" mass="45137" checksum="6D57D1E6BCDF0695" modified="2015-05-27" version="1">MNLDAMRQHDNINGKCLCTAGFYGDFCEKKIDFCMSKPCVHGYCESTLSGFKCKCYEGYSGDTCSSIFDMCTVSSCSGRGRCTPVWNATMCTCDKRWRGKHCDQLLDECMDVPCENDGVCETTSDRCEVVGSCLKQPCERGECIQFSNNTHLCNCPTGYEGKNCEKRIDYCVKNPCLNEGSCESLIDQYKCHCVPGFKGINCETNIDECLFGFCSNGSTCRDRIADYDCICDGTGFQGKNCTIDIDECTVTSNCVNGQCTNTHGSYRCDCEDGFIGSRCSVRDPCRPDAFNRTTHTCVHGVCINPTVQRDDAGHETSVHECKCHWGYTGSQCLVKVSEQKMLALSRVLGPMIVVLSVLAILGCVLFVIVFRGKRALHGHYSPSYQEQNGARLQMNSMVKLPPEERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYL3</accession>
    <name>A0A0D8XYL3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYL3"/>
    <dbReference type="STRING" id="29172.A0A0D8XYL3"/>
    <dbReference type="OrthoDB" id="5838215at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26428" checksum="A82402320391FDC0" modified="2015-05-27" version="1">MKVFTVGLDDKERSLKIDAEKADQTKVEMPVSAPPPIVMPRTPAKKRFGWGVLSWIVAAFFIVLLCLTISEITYNRQRDQAFLRLKWAELRQRLLGFEFLTQVQPLAKVHSPNPVNEISAFPRRTDLIEEQTTTTATPALNEIKQVDTTTVATNNEFSHKFDLLRMILSKIRDNVEEMGLDGDMQVHVIEMKPQYIKMSQQSIDDAFGEVAMPKQSLGPWQNEEIPNDLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYM9</accession>
    <name>A0A0D8XYM9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_04154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KN716225">
        <property type="protein sequence ID" value="KJH49733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYM9"/>
    <dbReference type="STRING" id="29172.A0A0D8XYM9"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF492">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="13">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH49733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="309" mass="34791" checksum="FB6FD88A6047D8B6" modified="2015-05-27" version="1">MAARMDVDDMIVRLLNVGVPGCSLVNNVKEGELIVLCQNARQVFLNQASLIEVQSPIKICGDIHGQFADLLRLFDRGGFPPMVNYLFLGDYVDRGHQNLECIALFFSYKIKYPGNFFILRGNHECAPINRVYGFFEECNRRYSSTRLWLSFQEAFAAMPFTGLVGGKILCMHGGLSPKLKSLDQLRQITRPIDPPNPSLHIDLLWSDPDNYVKGWQANTRGVSYVFGQDVVQDMLPALDIDLVARAHQVVQDGYEFFANRRLVTIFSAPHYCGQFDNAAAMMNVDEGLVCSFQIMRPTIKANKVVSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ33</accession>
    <name>A0A0D8XZ33_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isocitrate dehydrogenase, NAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ33"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ33"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF74">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iso_dh"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
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    </dbReference>
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        <property type="entry name" value="IDH_IMDH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="334" mass="37124" checksum="2E71425A2EE6034D" modified="2015-05-27" version="1">MRTQDIVYSPTMLSRLRITSMRFLTQTSAMEWTKANPKEASNIRTHILPGKRVPLSKYGGRHTVTALPGDGIGPEMINHIRTIFSYCHAPINFEVVQVSSHLVDGDMDSALLAIERNGVAIKDIDIVLIRENTEGEYSGLEHETLPGIIQSIKIVTRPCIERIARMAFEYTTLNNRKKVVEEIAKTEYPHIEFDSMIVDNACMQLVSRPQQFDVMLMPNLYGNIISNIACGLVGGPGLVSGMNIGEKYAVFETGTRNTGTTLAGKDLANPTAFIRASVDMLRYLDCNYHANLISDALWKTLVEQRVHTKDIGGTFKASDVVNMTLENIGSMMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ51</accession>
    <name>A0A0D8XZ51_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antioxidant, AhpC/TSA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716225">
        <property type="protein sequence ID" value="KJH49730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ51"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ51"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="15962" checksum="06E11976D9BDA19F" modified="2015-05-27" version="1">MAELLKGVKLNKKDGSSGNAEDVLKNKIVGLYFSAHWCPPCRQFTPVLKDFHGDLVDDGEFEVVFVSFDRTEADLKTYLEECHGNWYYIPFGSSMIQELATKYSVSGIPALIIIKADGKEITKNGRSDVQNKAPNSALSAWKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZX5</accession>
    <name>A0A0D8XZX5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZX5"/>
    <dbReference type="OrthoDB" id="5844444at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="32202" checksum="CF00CDF4AC9FDE28" modified="2015-05-27" version="1">MSVRQVLLSITVGRHCANIPHDSGLFDIGGTTFIYVVNGQGGGMAELKSITGDEPYTGVGNAPAPIPQPRGFWGRPRLVTLFAKYLHHSILLSGIILMALLTILEVTLAMVEVDTIVSQAPVIVPTKEDLDLQLFSFSHRSTLSAERSQIAEQVIKEPERIYDELFLSQIIVAFMEISGPHFMSTKAIKANHFNLKIKVYGLQPFDEILMRMIMESLPFDSPSRHFPINTRPNYDANANRGSFSSRLNPRTASAKTTNSFSSPSSNAPLSSGSVSLSSAVGGGFYKGKGNEMINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y033</accession>
    <name>A0A0D8Y033_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y033"/>
    <dbReference type="STRING" id="29172.A0A0D8Y033"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
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        <source>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48151.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A0D8Y0L4</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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            <dbReference type="SMART" id="SM01308"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="106"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="520" mass="59775" checksum="9B206E295148F879" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y172</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
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        <name evidence="9" type="ORF">DICVIV_03926</name>
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    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y172"/>
    <dbReference type="STRING" id="29172.A0A0D8Y172"/>
    <dbReference type="OrthoDB" id="5805018at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="140" mass="15667" checksum="DC49CFF8683579D8" modified="2015-05-27" version="1">MAPEFDKASTKLKSNDPPVALIKVDCTVEKSTCDKYGVKGFPTLKIFRFGSEAQAYEGPRDADGIVKYMRGQAGPSAREIKSINEFKKAISGDENIVIGFFENESKLKDSFLKVADTERDRFQFAYTSDRSVLKETGYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1H2</accession>
    <name>A0A0D8Y1H2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PHD-finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716203">
        <property type="protein sequence ID" value="KJH50540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1H2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1H2"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF79">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="410"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="54217" checksum="2632CB430E8D88F2" modified="2015-05-27" version="1">MQYLEDIVELVEDIPEEIGRRFELIRQWDHDVESKFIARYYVKLNDDVDKYRLIHRLSERKYELAVRSERLMSAVLEKVTDSSYLCKIELEVDNPGCTEAIERNFCRTLGLRPTSSHLTTCNMEFEPLDDMASTSSYNEYEFNGEISSSDSKETLRSRISNGQTDIEGIEIGSPMQFPYVSPQRGCTSAPKMKRRKHQSDPSQSLLTNHARKKQERVKTLRNNSSRQEEYRHKQQKSVAETGEPVVPLNSKNECVVAPGTIKTEVIDPSENDALCSEDDFDANDVMDLFPTLPSPPREIMESLNEDSLFLDDDHMSYDSNTKDYSQSPATPGILADSIPSSPSPSISVSSYDKKKRTSISFGNVNETASLHGRPRKICRMTERAVELLQNHKDKEKSKRKVDTVEADNYERWCFCREGSSGSMICCDDPECKYQWFHFECVGLTIEPKGQWFCSECSGKRHQRIEGPPGKSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1M3</accession>
    <name>A0A0D8Y1M3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1M3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1M3"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="315" mass="34192" checksum="14E7DF0772ED4ABA" modified="2015-05-27" version="1">MEQSDERASLISSRTQASCYGVIPVKEGAVLDTVEPVTLSWKDIRISVVQSGRLLLYGVSGFAKPGQVVALMGASGAGKTTLLNRFLARNLKGLEVEGSVLVNGNEIGRQITAISGYAQQEEMFIGTLTVREYLSIQAVLRTTLPKKQRESRVGAILSELGLTKCQHTRIGIVGVRKGISGGEARRLTFACEMLSNPALLFCDEPTTGLDSFMAENVVTVLSNLAKGGRTVVCTIHQPASQLFLMFDRVMLLASGRTAFFGTPKDCIKFFDDCGYPCPHNYNPADLLIHTLAIIPNEEEACRVRVNQICDAFQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y287</accession>
    <name>A0A0D8Y287_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_05235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y287"/>
    <dbReference type="STRING" id="29172.A0A0D8Y287"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH48676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="543" mass="60508" checksum="4CACBC14B40DBE00" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2R1</accession>
    <name>A0A0D8Y2R1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_05046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2R1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2R1"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH48856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="199" mass="21975" checksum="B7EA13E8951F75B1" modified="2015-05-27" version="1">MIGIAGTICGFVVVLEAKDWRWVGPKAFQSTEQNNEWGSVHSMLGLIACVVAWAQPLNAVFRCSPEEKWRFVFNWIHGFLGFGAWLCAASATMIAVVHFETMFSNRDAALGLYIAFVAIASLTNLTMEALTFKSWQRDRHRVTSEMEMVPVGGSDSVSVQNTTEKIRIVQFFLLIAFVVVSISTAIAIAVLIGKKPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2V0</accession>
    <name>A0A0D8Y2V0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716209">
        <property type="protein sequence ID" value="KJH50344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2V0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2V0"/>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20389">
        <property type="entry name" value="Tudor_ARID4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20390">
        <property type="entry name" value="Tudor_ARID4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23016" checksum="67621BEED78C58CD" modified="2015-05-27" version="1">MQSDDPAFLSPGTEVSAKFKGAFCEAKIKKICKSVKCKIVLKEAPFGSMVVEEHLVKGTLEVNQTVDVYHGKHSVKGVIQHIKDCSTYHVVFNDGDEKVLRRTQMCLKGAKHFDTESNLDQMPLYNPEQFCAAPKPQAKAKKIKKQKRRRDEESEDDEGKKRKKRAAASAASVAIGEMDHVIIFNSHFLLFLDKFIRKDHHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y355</accession>
    <name>A0A0D8Y355_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cathepsin X</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_02705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y355"/>
    <dbReference type="STRING" id="29172.A0A0D8Y355"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042395">
        <property type="term" value="P:ecdysis, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000060">
        <property type="entry name" value="Cathepsin Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018647212" description="cathepsin X" evidence="11">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="53"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34323" checksum="4AC85B5620DCEAA1" modified="2015-05-27" version="1">MRLLLFFLSILLLISAANNRYNLHGCYKKTGTIHQHRLNRRIYEHRNYDFSQLPVAWDWRNVNGVNYASVDRNQHIPQYCGSCWAFGATSALADRINIARKNAWPPAYLSVQEVIDCSGAGSCVTGGEPGGVYKYAHEHGIPHETCNNYQAKDGKCDPYNRCGSCWSYSCFPIKNYTLYKVKEYGTVNGINAMKAEIYHNGPIACGIAATKAFGSYSGGIYKEVTYDRIDHIIVVHGWGVDHDTGVEYWIGRNSWGTPWGEQGWFRIVTSAYKNAGSKFNLKVLLLNRYFQIEEDCVWADPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y375</accession>
    <name>A0A0D8Y375_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_04864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716248">
        <property type="protein sequence ID" value="KJH49026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y375"/>
    <dbReference type="STRING" id="29172.A0A0D8Y375"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="49631" checksum="85AF67D333C6B6C8" modified="2015-05-27" version="1">MFPENIIQATFQQVQTYYVPIKPKLQRHNGTNNVSEVIIHKPQLTYTNEMNVLVTGSNKYNFYHCYYWNFSQYEYEEYNEIVDERAGDDRIFWPIYTNKYGLIVFCSGFGVILSILGDQARLMINFFIVLDAIIMRWISALMWCYPIGILSLVCKNIVDIDNLTETAQALAMYVVTVICGLMIHSLLTLPLLYFIVTRKSPFAYMTGMLQALATAFGTASSGATLPVTFRALEENLKIDRRVTRFVLPLGATITMVYFSGATLPVTFRALEENLKIDRRVTRFVLPLGATITMVIALNYLISLSQSVTTTVASIGSGSVPAGLDTIVIVLTTVGLPAKDLSLLLTVDWLLDRIRTSVNVLGDGFGAGIIHHLTRDSLVEADNDELIRQIREDIHHLNNPELNPPQLVTNHVSLQTAAQNQTYIPLQYYTVSVILFNLLTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3G0</accession>
    <name>A0A0D8Y3G0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_03238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3G0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3G0"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH50564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="190" mass="21985" checksum="DE88D9D73B468D6C" modified="2015-05-27" version="1">MGLKGSKPKLSKEDLEFLKKNTNFTEEQIKEWYKGFVQDCPKGHLTKEQFIKVYKDFFPSGSAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEKEMIKIIEAIYEMLGPEVTKSADDSPRKRAKMIFEKMDVNNDKELTLKEFVDGCLADKELFQILTNEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Q0</accession>
    <name>A0A0D8Y3Q0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716243">
        <property type="protein sequence ID" value="KJH49176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Q0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Q0"/>
    <dbReference type="OrthoDB" id="5865359at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF75">
        <property type="entry name" value="SULFATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="26611" checksum="F6FFF4185322125E" modified="2015-05-27" version="1">MADDIEISTTGDMFDYCPFTPPDPWHSSIRKFINVKHGYLANCRLHEDLLPITKIENGAIIIKKGHEAFKCKARYIDENKYDVTDWKTIDTNQFNCGDFVETNCTSDNRTNRFIHKQISEINSTKPTSLNSEENPDVHIIIIDSVASTQIIRALPRTVNFLLHGMDAVEFRKFNKVGSNSRPNAFALLFDLNLSTITVVVDNSDFLSKISTEYCMDNLAIGFSVGRAKPVWVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4K5</accession>
    <name>A0A0D8Y4K5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_02895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4K5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4K5"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="10">
        <location>
            <begin position="53"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH50934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="489" mass="54078" checksum="5B15AD3E5EE88524" modified="2015-05-27" version="1">MIRNIARGFLERMMQTVGTVCPLHYHDHNSLSVKRLSGNRGTKDYAFEMICSTIRFGNGVTCEIGYDVKNLGTKHALVVTDRNVASTIGFKTVVQSLQSLGVRYTVFDDVLIEPNDESMLKAVNFARNSACDSFVAVGGGSVIDTAKVAALYTSNPDAEFFDFVCPPFGKNLIPPNPILPLIAVPTTAGTGSETTGAAIMDLPKHNCKSGIRQRCIKPLLAIVDPQNIESQLQQNRNPACIILTHYFLFGMPRNVAIYSGFDVFCHALESYTALPFNQRVPCPLRPQLRPLYQGSNPISDIWSLEALKIIRKYFRRSVNDCFDNEAKYHMLLASVFAGIGFGNAGVHLCHGLIESLSVMYKSSRKAFYVSSQGKSYFDVDYPAKKALIPHGLSVVITAAADFEFLAPAFPERHAEAARQLGVDVPISADSDYIAKKLCDEIRGYMRDFNVPNGLKDLGFQFSDIVVLWLADSLETEKKAEMLVKTRMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y502</accession>
    <name>A0A0D8Y502_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_02756</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y502"/>
    <dbReference type="STRING" id="29172.A0A0D8Y502"/>
    <dbReference type="OrthoDB" id="5818798at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH51089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="20257" checksum="8AA1A803BD41AA2F" modified="2015-05-27" version="1">MRLSMRLLKPAANQNVNNPRLWQDPVLGYFETHGKTEFLPGQEYNLTDEEKKAVLWRYRVKEILKKEYLRREYDPHNFKYKEGVVMDPAMFRWYSANMTQAEFFRMTPRSVFLYSGAVILAFYLYTRLVYVAVDKSNEACLDGDLLWWDRQQGRAVSVSGSGHFAPSIGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5C1</accession>
    <name>A0A0D8Y5C1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5C1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF102">
        <property type="entry name" value="SSD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="311"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="958" mass="109860" checksum="AA7EDD22A676DB94" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5I4</accession>
    <name>A0A0D8Y5I4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH51995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5I4"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="68" mass="7843" checksum="9EC5CEB455BB6EAB" modified="2015-05-27" version="1">MFVEGSYVFDPPSVFISSAESIHLIFHQFRDIYRIVAVDIIPQNLHIQTVPFHLFPCHGSVRVFLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5I6</accession>
    <name>A0A0D8Y5I6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5I6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5I6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336229" evidence="7">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH51452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30618" checksum="D5BDCBEC88109480" modified="2015-05-27" version="1">MLHILTFLVIIPPIETFYMSEFYETVNTWNGPLQYDEDWGYTDVRENAHIFWWLYAVKPKMNRPLILWLQGGPGASGTGFGNFEETGPKTINSSDNPATWLQLADMVYVDSPVGAGFSYVDNEDAFTTNVTQIGHDLLVWIRQFLVIHPEYRIRPFFIFCESYGGKVGAEFAQLITKEIDIGNLQLNFCGLALGDSWISAMDYVNSWGQYLYANSYLDSNQLARVNAQAKQCQKKVDNNQWTKATICWNQMEDLIEMVDILWNFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6U0</accession>
    <name>A0A0D8Y6U0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716162">
        <property type="protein sequence ID" value="KJH52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6U0"/>
    <dbReference type="OrthoDB" id="5835493at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="23071" checksum="D5C85BE53E25AD1C" modified="2015-05-27" version="1">MALIETCEAIMQIMQGNPDHLPSVNSTQQLEYPPNTAPSEVFAKSLHNVKPFWYDEELVSQCKTQCAMIAAKQREFQNRGRRQIHLIRTFINNVYFEFEDLKKALMKSKDELEFAQEELKSGETILRKRAVKKATERYENKLKALDSFLSERFTELKNQHVKEIQMIINEAQCYHDWMASYCRPLANYKVHRPPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y729</accession>
    <name>A0A0D8Y729_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotyrosine interaction domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716207">
        <property type="protein sequence ID" value="KJH50386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y729"/>
    <dbReference type="STRING" id="29172.A0A0D8Y729"/>
    <dbReference type="OrthoDB" id="10069833at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695:SF3">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="52372" checksum="721E151D9BB59C9A" modified="2015-05-27" version="1">MVQKLENEPTIEDQPKNPPSPKSRLAVLKRNKKPNTASDPFRFQGNGVTYKGKLIGERDVESARGDAMCADAMRTAKAAVKAAGAHKTRILLQINIDGIKIVDEKSNAVLHNFPVSRVSFIARDTTDARAFGIVFGQPDSMFCVITAQTADQAVLAIRDMFQVVFEMKKKHIEQVKQQQEERKETTPADSVAVADLLDLETEVQQIEQGLHQLEQIPTNTDVFGATPFADPFQDNFTNNTSPLNGTYMNNPLNGSSHSPLQIQPPFIPQPQNTTWPQQPVAQLTPPTIQLPTMAPAAPFPGAWNTPHLQHTHSIPSFNPAGFSDTNPFASAVNVTQHVPSRDPFDTRSVLQVHPIVQGVRTADWGTTKENAVPQMHHANSFTNSNCFGDNNKQSQNHMNWEEPRKVTSLEEAFTKLVDMNALVSRPANDTKKNPFEHILNPPKASLNSLGSMPMRPTPAVVANQADPFSDDFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8D7</accession>
    <name>A0A0D8Y8D7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8D7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8D7"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12482" checksum="966BDBC11253644B" modified="2015-05-27" version="1">MMFPSGLGSSELQQAASEKVKRDVGKFVMFGLLIEAGKKMRTACKLRIDVLFSRVHTLTGRCWDVCFADYRPPSKLDGKTTTCIQNCVNRMVDASNFMVEHLQKMEGGKGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8K2</accession>
    <name>A0A0D8Y8K2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8K2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="59" mass="6977" checksum="C1ED506C57911619" modified="2015-05-27" version="1">MLRLSQSKRWPVLGKKDIKGVFFYVLSFYLGKSMCMWFELSPVDEQIIKRLVLKYSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8R7</accession>
    <name>A0A0D8Y8R7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DICVIV_00623</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8R7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8R7"/>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="454"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJH53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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    </evidence>
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</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
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    <sequence length="91" mass="10455" checksum="A3D404BDF2F3F7B9" modified="2015-05-27" version="1">MQSGCMIWADFRLFSFLRHVIGVFSIRRTDLQLDSTRWQTKSSFPLGNGRVDIVFGVVGAMYDSMFGDGILLLASHSYHTVYHRTMRGKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAM7</accession>
    <name>A0A0D8YAM7_DICVI</name>
    <protein>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716176">
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="698"/>
            <end position="722"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="769" mass="85222" checksum="895F0FEBA77A9873" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBL1</accession>
    <name>A0A0D8YBL1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
        <property type="protein sequence ID" value="KJH51946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBL1"/>
    <dbReference type="STRING" id="29172.A0A0D8YBL1"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39348" checksum="A7200E383A6577A7" modified="2015-05-27" version="1">MVIFIMINLEKIDVKEMVVDQNGCRYITSVAFPSAPLNFDVVLTAPNQVKLTWDYPLHVNGHSKFGGYYVYVEKLLNGEPVNRRRSKYDVINDLSKRYWEIDKLEPNTEYAFRMNAFNRNGDGEYTETRRIITGGIPPQQPEIQSVVLLGDETPLRARVEWKRPQLAPLESPIDRYNLWYKDEGNSHYMKKVVNGTMNSAELTGLCKYITTFYHLFCTDQVFFTEVMGRVYEILLGAENVEGRSANATEQLVTPIGNPEGEPLNVQYEIVNGEMRITWDPPAEDRRNGNITAYNAILTPMDSEGERIEKQLLCLMVLLGELTFILPPRLFLLLSSYMCKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC16</accession>
    <name>A0A0D8YC16_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC16"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="20386" checksum="654D1B9BECF3AE1E" modified="2015-05-27" version="1">MVFTSLYKEEQKFSTYKSTVSIRIARLRHESDFRFSRFGTKRFAGCRTFTFRQTFSADTTCTLPAKDKQMFLDFFSKHKFPTNWDCGLENLAKGEFDRAEKATKNFPLSDVAAQYYTLTSKGKDLKSALEKIPPLFLEDGEYLNRTAKLGCNRERREELILACVIQPLYETDVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YC57</accession>
    <name>A0A0D8YC57_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YC57"/>
    <dbReference type="STRING" id="29172.A0A0D8YC57"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="67"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="254"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="466" mass="51821" checksum="01F717DC40D8D4A9" modified="2015-05-27" version="1">MVAVEVAVTKAVEYEIDQWISENQVTLDGRGIPRPVWEFNEAALPNELSDLLYAKFQKPTVIQSISWPIAMSGRDIISIAKTGSGKTLAFMLPAIIHTTKQAGRGRYEGPSVLVLLPTRELAQQVQEVSNDFCNALGLKMTCLFGGASKGPQARDLEKGVDIVVATPGRLLDFLDNGTTNMKRCSYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTLMFSATWPKEVRALASDFQRDAAFLNVGSMELAANHNITQFVDVLEEHAKQPRMMQLLNDIMNQPECKTIIFVETKRKADDLTRWMRRDGWPTLCIHGDKNQGERDWVLSEFKAGKTPIMLATDVAARGLDVDDIKFVINYDYPNNSEDYVHRIGRTGRRDKRGTAYTFFTPQNAPKAKDLIKVLEEAGQSVPQTLRDLQGRAGSGSSRGRWAGSSTGGMKRGYSGGDDYVGKKGRYDNGGGYGGSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YF88</accession>
    <name>A0A0D8YF88_DICVI</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YF88"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="20653" checksum="6BED90E540BCFE07" modified="2015-05-27" version="1">MEGGSADDVGTSSTTESSIHQTTNFIMNGGRVREESSSTITIIIAGIIFFTICAFLLFVVLMLQRKNRMKKIEMYKEMEKRNEMARRKKKILQKKKKEKRKRRRAKKKLSESTDSSSRKGGVLKALEDFLAVQTESITKAGDSEIDVEMPSNPQPDSKELPSPSEKAKQLSNSSATSLTMRNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X536</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722282">
        <property type="protein sequence ID" value="KJH39660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X536"/>
    <dbReference type="STRING" id="29172.A0A0D8X536"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="89" mass="10345" checksum="AAAB79BECA0E57BB" modified="2015-05-27" version="1">MSGSIARMTESVLLNVVYAHWGPKGVWKLEIIQLVLVLSLWLIFLNRLVPLEKLSPIEWDKSYRMTIKTDEKSDKFVDKDAKNIDLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X540</accession>
    <name>A0A0D8X540_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722211">
        <property type="protein sequence ID" value="KJH39665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X540"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="32" mass="3469" checksum="84402D5F5AB1EC6B" modified="2015-05-27" version="1">MQPSRHHCCSTTFHPECMGTTAILCSDCNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5V0</accession>
    <name>A0A0D8X5V0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719295">
        <property type="protein sequence ID" value="KJH39910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7961" checksum="90F93A0446453BF9" modified="2015-05-27" version="1">MNDDSVVSAYVDNKPQNLQEGMNRFLKMLEITFRRDTESYRPRINKKDSIKDMEQKKSGQFLFIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X6J4</accession>
    <name>A0A0D8X6J4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KN717739">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X6J4"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20251" checksum="6A1868325CC70BD9" modified="2015-05-27" version="1">MDELGMYFRLTYGYFVPPYYDENQVHIRSSDVDRALTSAQAFLFGFYPAQGSFEWQKGNSWHPVPIHSATPGEPDLLLKPSSTLCKKVEMLVKEEYRQQANYYDIKYADFFDSVGVQSGISNFSYVNMDNMYYIQAERLVNRCQNYLGEHRAAEAVVGLQLAAPQTYKAIHHSAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X869</accession>
    <name>A0A0D8X869_DICVI</name>
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        <submittedName>
            <fullName evidence="7">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_14108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN718870">
        <property type="protein sequence ID" value="KJH39982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X869"/>
    <dbReference type="STRING" id="29172.A0A0D8X869"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH39982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="30498" checksum="478730951A15B517" modified="2015-05-27" version="1">MSEERYRLVVLGSNKVGKTNLIRRYLYNEFSEKYKETVEDLHSRQFHIKTSVLNDQQLEFDLLDLIWKLWIHPYLSSHRVQLIKREVGRIFLIRKLFYIVLQGVSLLLDILDTNFNFPDMRKVSITSANAFLLVFAVDDVPSFKEMSDIWQEICERRPDIMTLPVVVVGNKCDLPSKKIFEDTAKAFTSRLNADVRYLEVSAKCNIRVTDIFRTLLELSGFPRCSDILFIELLFSWARDLDEGEHFRKLIFFSLKQCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8T8</accession>
    <name>A0A0D8X8T8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716936">
        <property type="protein sequence ID" value="KJH40995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8T8"/>
    <dbReference type="STRING" id="29172.A0A0D8X8T8"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18347" checksum="C6E5B14B34C90183" modified="2015-05-27" version="1">MIVGRPSLQSKSSVQSEILISMCNVRRGKLVHRWSRNKCSLYNGSIRIQKDTGNDEVFDLLRCRVDVGESRHGRCLRLHKSASDILLCFDDSETLELWLKGCRQSGQHKMCDLSDRMLTLLPESLFRPEFDEVEQLNLRRNSLSVKSADHVSDSEGNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X961</accession>
    <name>A0A0D8X961_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717423">
        <property type="protein sequence ID" value="KJH40282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X961"/>
    <dbReference type="OrthoDB" id="5783969at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010761">
        <property type="entry name" value="Clc_prot-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07062">
        <property type="entry name" value="Clc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="170" mass="18959" checksum="F1CE56ED33116D02" modified="2015-05-27" version="1">MRLATIAFDGLILMSVLCLGVSLMVFVINAEMLESKYLIGVKNTFEKYYGYSFYLACLALLLLVFTALGAVLMTTFTFFSPKMLADTGGNYSSSENQYNGGTNHVNTSRRTKPELYAQDSVSFIDPGLLRSITPVLQSTPQISLQHGDYISPIRSPNGEFQLTTRHFYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9K7</accession>
    <name>A0A0D8X9K7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_12752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </source>
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    </evidence>
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        </source>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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            <strain evidence="7">HannoverDv2000</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </gene>
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        <lineage>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716708">
        <property type="protein sequence ID" value="KJH42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEK9"/>
    <dbReference type="OrthoDB" id="5805447at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335566" evidence="1">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="359" mass="40203" checksum="062FD38F7ED56DFD" modified="2015-05-27" version="1">MKVKLLLFSTSICLLINAELKCPNNTSSYDMEVCDPTRRSQCPSGFTCRKSFNTENQLNRFHICCETQPMTIEDWFFETELTPKILSQPPKSMLSSVEMAPLDSITALPGVRIGDEVIILEYPQYKTAHIQSVIFTTPPPIGGFLHVMTLIGDPLLNPFALFFTYNLPSTGGIRLPIPNKLQGLTGRAIYIDNSTIVMKRNSYPLLNPFALFFTYNLPSTGGIRLPIPNKLQGLTGRAIYIDNSTIVMKRNSYRSQYVVLTYRTSTPITIGNRQNINSPFDDITIGLTLMGECRDVECLLKTTTFSKQLGIPISGSIFYLTTKDTIFEKNRGCEDTSASSFTVLTETIMITIISFVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEQ0</accession>
    <name>A0A0D8XEQ0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716974">
        <property type="protein sequence ID" value="KJH40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEQ0"/>
    <dbReference type="STRING" id="29172.A0A0D8XEQ0"/>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="321" mass="37134" checksum="3282A767034FAFAD" modified="2015-05-27" version="1">MDGEERNCSKLEKGVIDVSISSCTPCPDCRTMIYDEDIMSGWKVDDQSLITNCPHCFVPDEEFVQGSERKGVFAPRLTIHMEWKEKPSMSWYRPNVFDLNSEVSADVSSEVVKDFCLSYISPLVLRREVETLLAGDMFALKDPKVMNSHPVVFWNIVFYLRRLALPSHLYMWISPRVHVRCVYDRPLDHIGPIPIYLANPNHKIVSNEKVSRHLPVWRTVTQAVQENKLFTAIQALINDSRRVNDNGQITLGQHFPVFRDIQFASLDSFGRALLRDNLDRQYVEEYSKLPPRIMCILPHQDKPQSPVQRACRKVFLPLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF39</accession>
    <name>A0A0D8XF39_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_10808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716584">
        <property type="protein sequence ID" value="KJH43183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF39"/>
    <dbReference type="STRING" id="29172.A0A0D8XF39"/>
    <dbReference type="OrthoDB" id="5876805at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH43183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="552" mass="63124" checksum="D3FA131C041FD9BB" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFF4</accession>
    <name>A0A0D8XFF4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_11581</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KN716665">
        <property type="protein sequence ID" value="KJH42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFF4"/>
    <dbReference type="STRING" id="29172.A0A0D8XFF4"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
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        <text evidence="4">Amino-acid biosynthesis.</text>
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            <end position="215"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF07992"/>
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        <source>
            <dbReference type="Pfam" id="PF14691"/>
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    </evidence>
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        <source>
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</entry>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716558">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14027" checksum="7EC9B1BFFC6131DC" modified="2015-05-27" version="1">MELLGKAVDLRDSQILNLGSYNKMIWRRRFMAAATVIAWGPVDDGIHVASISRNKNHIAVVVLIAALATPDWAVLDFMNTEYQHVHVQLGVWGEWRTIKNATHKTGIRMDPTLSHATRERRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFS9</accession>
    <name>A0A0D8XFS9_DICVI</name>
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        <name evidence="7" type="ORF">DICVIV_11420</name>
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    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XFS9"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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        <property type="entry name" value="PLPL9"/>
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        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="ARBA" id="ARBA00023043"/>
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            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="262" mass="29484" checksum="E194E4A9409728A4" modified="2015-05-27" version="1">MNMSLYMNMRSIFRKIVIVGQTLFTRKSIPSVLWEQNVKVKVPKHDSRGVEQMAKTLFGHSHMASFPVNSPRVIVTVADTRRSPANIVLFRSFSPRLPETLREQMDYLDPEKILIWKAARCTSAAPFYFNSYNGLSDGGLVANNPTQVLIADFLQTTRLEQQYSPNKEVGQDPSIACVVSIGTGLNPTKKNPLQIARGFITVINNAKKIIQILLRECFIHGVGKYELNQLAEFLLMKSTTTDSHCKIASSTVEKMRTDSMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGE2</accession>
    <name>A0A0D8XGE2_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">Exosome-associated factor Rrp6 N-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_10256</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716531">
        <property type="protein sequence ID" value="KJH43720.1"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome-associated factor Rrp6 N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14900" checksum="2E5C5B3F404F89D3" modified="2015-05-27" version="1">MKYDDIMRRAAVLVRTASDLPRRGDDFELCNSFSMFTAFMEQQETRIRLMYVIFVYNLLSALMRNTGCPTRMPKINADVEEYLERIVMVDDHIVERTGIVMDELDRGGRKDVEVPKTVIGAESTKKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGH6</accession>
    <name>A0A0D8XGH6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_10217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XGH6"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
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    </dbReference>
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        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
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        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
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        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="16394" checksum="F3C75725F1C95300" modified="2015-05-27" version="1">MASTPDLIKDEQAMYGPFFGTLGVTSAMIFTAAGSAYGTAKSGTGIASMAVVRPDLVMKAIIPVVMAGIVAIYGLVVAVIVSGKVAPGGPEYTVNQAFAQFAGGLVCGLCGLGAGYAIGIAGDAGVRALSQQPRIFVGMILMLIFAEVLGLYGMIVALILGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH00</accession>
    <name>A0A0D8XH00_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_10043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716514">
        <property type="protein sequence ID" value="KJH43935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH00"/>
    <dbReference type="STRING" id="29172.A0A0D8XH00"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH43935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="26369" checksum="7A1C342A412F553F" modified="2015-05-27" version="1">MAAGTSFSTQQLDVICTALYQAKDGDQLVHLFRDLDSQVLCSEWTSQSIRIAYIYALYHAGNFDRLFEVIGRSRFDERYYKELQEIWYKARYKENESKRGKELGAVEKYRLRRKYPPPRSIWDGQETVYSFKENSRKYLKQFYKQNQYPTLDQKKEISRATDLEIVQISNWFKNRRQRDKTRMECAQYTRPQMMQLQTLAYTNLPLNMNINMPYTCKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHT7</accession>
    <name>A0A0D8XHT7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716570">
        <property type="protein sequence ID" value="KJH43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHT7"/>
    <dbReference type="STRING" id="29172.A0A0D8XHT7"/>
    <dbReference type="OrthoDB" id="5860852at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="215" mass="23783" checksum="2B7DD827A4EE6870" modified="2015-05-27" version="1">MRQHFFQINEDFVFLERYIVTGLLPNVAYSFKIEACNEAGLTSNSNKASETLTLTPSQGYPVGIPSTPRVLVTSTNSVSLEWDSNDDLASDEYTVLYKSEGSTVWNELNCTTTFCSIDGLKEGVSYVFKVAARNEAGVGTFSNETVPVKVTLSIPPVVTKAIKDVSVPKKRTLQLECHANAEPAPEYIWYKDGVEIIPRSANTEVLEFSYSKCKD</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="EMBL" id="KJH41991.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="264" mass="28963" checksum="B8EAE9A9E6D3255B" modified="2015-05-27" version="1">MLEALDGIEAAVYRGQDRLKESDRRASNVSFQKVIPIPIKQAKSKKSTTSTTEKSEANITSSRNSTSYSESTRSSSESLSSDARSRISFRKRANNSPPKVSAPVLLPRQCSSHTLLQASTSGESLESDRTAKTNSPSLTRHFSPPDVQSLRLKSLIFLLTDSTTSCRRLNYCHVALPVAANSTSSLNSINSRMEYVTIDPISTTAAREATTAAREAANMHLSSFERARAFSTSMTGSIEYFGFDINWTGNTTRFLPEISKTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
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    </feature>
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        <location>
            <begin position="18"/>
            <end position="27"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="80" mass="8586" checksum="487BA1F1142E9D75" modified="2015-05-27" version="1">MLMFFMMEGQSSASSPPSTIPSPPTMPPNDMDDAAIEDPKPMPEGSRAGNSFPSILANMLGDALGCVGFSWVCYFFINAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27105" checksum="857F826829EF2961" modified="2015-05-27" version="1">MEGLSTKNKKHTFTSETDDWVLKMSVEKASDVIPNVALCSGHQAFPMTYQPNESGDKLYTYEMKGNSIGNLQKLRVGMGELGPSEHFYIKKMRLENRSTKTMLRFPSVDTEFQRNQVYEFSPVYPDIQPTLNILYTISLTTIESSGLFSTVINIIGEDGDSGMRKFNDDVPFVEGTNHNFDIDAVNLGVLKELDLLIEGDENSSWLVRIVVGMADSNVKYITDLANLPKPGQLVQLPLRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716543">
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        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="Zinc finger RNA-binding protein"/>
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    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="434"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="806" mass="87134" checksum="D6D90975C4C3EB52" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIN6</accession>
    <name>A0A0D8XIN6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716539">
        <property type="protein sequence ID" value="KJH43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIN6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12472" checksum="E2C487394DCF5C1B" modified="2015-05-27" version="1">MMTVADDFKHKKVNKNFHDVPMECRYIEEKKDGDGKNHSCRTRGRNEDHSLLLIEICQKENSIDIDIDIDIDIDIDIDIDIDISFKERRKCTKKKAKNSCDVIFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIS0</accession>
    <name>A0A0D8XIS0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_11820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716697">
        <property type="protein sequence ID" value="KJH42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIS0"/>
    <dbReference type="STRING" id="29172.A0A0D8XIS0"/>
    <dbReference type="OrthoDB" id="5817502at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF405">
        <property type="entry name" value="PROTEIN CBG12249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="48016" checksum="E0E50F008F8ED916" modified="2015-05-27" version="1">MAVVCMVNSTAFPAEESSHGTEMSTKARPKCQLVNSDLESAVDAGYTGDLLWSPAMQSMLLSATFYGAIVIIPFAGITADKYSPKLIVLAATCDYIIVTLLTPLLARWSFYAYFVSRIIMGIGEGFIFPCFGCIVGKWFTKIEKSTVAAMYTSGNQLAAGFSTFISSYICTSNQGWPLIFYMFGSMGSAWCILWYTITTNSPYTNKFISKDECSYLSEHIEHVKTKSSGPVPWRHMLSSRPLIAAVLCQYTYNLQASILQAFLPTFFKEELMLPLHRNGIFTMVPFTAQLVSKNILGIFADYLKEHKIIGHTKCAKIFQSIGSFGSATMLIMLATLTSCDNPDLALPLLALYGIFFSAGICGFFTSILCIAPPFTGTTTSISMVFGMIGNICGPMMLGAVSKMGVSNKWVASFLLCSCSNVITAKVQFWAKTQTPRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJR5</accession>
    <name>A0A0D8XJR5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum metallopeptidase 1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716446">
        <property type="protein sequence ID" value="KJH44808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJR5"/>
    <dbReference type="STRING" id="29172.A0A0D8XJR5"/>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053973">
        <property type="entry name" value="ERMP1-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22248">
        <property type="entry name" value="ERMP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1-like C-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20134" checksum="6F4CFC588D6DE111" modified="2015-05-27" version="1">MISLGRCRSRISRYIRYKVLDETLSSPMTKITLINKEEQGKVIIYDFLLKGAEQMSIFVVPQKGWQIANCSLSVPKSTLSESTLFIFLTCSSSNCDWTFRITLKHGGDPNENNETELLLGVANHHLHGPYMQSTVIKRLLSEISMRRQSDPSWSMAVPKGAGHRNEAAACSIRCIQNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK97</accession>
    <name>A0A0D8XK97_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJH42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XK97"/>
    <dbReference type="OrthoDB" id="5849700at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10354" checksum="703AFE3DF33C2B95" modified="2015-05-27" version="1" fragment="single">RLSINNAWKTLIDNEVLTYECRERLKTIFSSNHSWVNVSCLSQKHVVPRCDQLPHDTITLAEYSSVNPLWLFTCVLICVACVILFSLMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKM3</accession>
    <name>A0A0D8XKM3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716483">
        <property type="protein sequence ID" value="KJH44312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XKM3"/>
    <dbReference type="OrthoDB" id="5872807at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13062" checksum="8E6CB28F208B2786" modified="2015-05-27" version="1">MFIASATVFPMSSIRLLNPNDADDSDSSNSSDSPTTVPRRSATVSPSMRSFLRDHPRHVALKRRRSEFNLCGEKERRRKSMARNSRERSVGRRRLRKTNSEPNVEGMGVINKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XKY2</accession>
    <name>A0A0D8XKY2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nematode cuticle collagen domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_10986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716601">
        <property type="protein sequence ID" value="KJH43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XKY2"/>
    <dbReference type="OrthoDB" id="5874994at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF241">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01088">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="209" mass="21747" checksum="8D52449A818DC486" modified="2015-05-27" version="1">MDTDRRERAYRFVAFSAVSFSFVAIVAVFITLPIVNNYINSVHARVQSEMEFCKLSAKDVMTEVAEYRALPKIVLPGFLRTSNQTRQRRQTSQGTCQGCCLPGLPGPDGPPGRNGMPGRPGAPGAPGFPGRPPAICEQVTEPPCNPCPPGEPGPPGPPGDSGNPGQPGHPGRNGNDGPPGPQGPPGQPGSPGDTGRDGARGDPGRPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNI0</accession>
    <name>A0A0D8XNI0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="9">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="9"/>
    <dbReference type="EMBL" id="KN716369">
        <property type="protein sequence ID" value="KJH46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNI0"/>
    <dbReference type="STRING" id="29172.A0A0D8XNI0"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="398"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="489" mass="54764" checksum="B2F50A93AD6E83F9" modified="2015-05-27" version="1">MERVLSPLDSGRFIMEHANLIKINEEGVQKVARMILDSVNDGSIANTEFTSQVLHPKGEGKSTVDWIFLVDTINFSFWPDKGSKYEVTYNGIKYTGYFALCAAVNKALALGLNITSAEWMANARQEDVDQILKSDGGYSIPLLVERVKAINESGSVLLKKWNGSFYNCIEAAKCSAMKLLHIIVENFESFRDFAVFRGQKVSFLKRAQILVADVYAALKDECSEDLTMFADYRVPQALAYLGVLEYSEELMHILRNGNCLPNGSAEEVEIRGASIWACENYVVMYVCRYCCVVSFSFAHIIPVRMFKKFDEKEDVTGATQLKSSIQKGIRNKLIESYPQIEPYLAEILPKKENFKLIKCRDHIELIADHNGVVQFLKTRNTDWVPTLRLLHKYPFILPHQQVDKGAIKFVLNGSSIMCPGLTSPGGKMTPGLAADTIVAIMAEGKQHALAIGQMKMSSEDIQSVNKGVGIDNLHYLTDGLWRLAEKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNP6</accession>
    <name>A0A0D8XNP6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716362">
        <property type="protein sequence ID" value="KJH46243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNP6"/>
    <dbReference type="OrthoDB" id="5858931at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40288">
        <property type="entry name" value="PROTEIN CBG16535-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="122" mass="14089" checksum="3AC2D34672398CDE" modified="2015-05-27" version="1">MRFGWCIEHTTALLIAIFSLLCKPKPLWLLWPGLLLQSSYSLGLSVLTMATAPKHLEALGGRIDVELALMLGAYISGFLFNWIFTFILWHYYWHLEGLDSTPSDRRRASYKTPRVRKKIGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNZ1</accession>
    <name>A0A0D8XNZ1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_07590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716357">
        <property type="protein sequence ID" value="KJH46348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNZ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XNZ1"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH46348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="319" mass="35839" checksum="756801676F0136AB" modified="2015-05-27" version="1">MNDIVCLEGCTLKGRSLETSSGCSALDTLLGGGLPVTSFCIVDELKSRTYSTSIVKYFLAEGLYSGHDILLIDPLGGDKLLKEIPTKYVTEPTISSTAQRISYCEDDLSIAFRYATRPKVNSSIGGKNRYDLSKSLDIDIFSSQILRFDGPLCYESLYHYVTSLCKNSRYKGTCSSTKKLLRIVINHLGSPIWKDTDNFSPFLVRTRSILRSANVVLLGTASSETMFKRHSDELYVTADLYLQLVAFSEEEEKTFLGSEKYHGFLRILRLPRLTSLCTYNPPVDLVFTQKRNSFDVSVMHLPPIFNDDKSTKKPCEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP36</accession>
    <name>A0A0D8XP36_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsp90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716354">
        <property type="protein sequence ID" value="KJH46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP36"/>
    <dbReference type="STRING" id="29172.A0A0D8XP36"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="746" mass="86741" checksum="0934A762B2ACC8F6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XP98</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="126" mass="14467" checksum="47CB6D4E44BD0016" modified="2015-05-27" version="1">MSSCRDSHEIQQKSDEIEAEVAKEKLKSCRTMMRQAEENYKALEGFFVEIKESVAQFVHTNFPDIAENARLSNEQEKELSKVEDLRKSVNEMRRKIKMAISSADSLALESHISQTNRSLDIGMDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPA0</accession>
    <name>A0A0D8XPA0_DICVI</name>
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        <name evidence="5" type="ORF">DICVIV_07463</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716351">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="310" mass="34774" checksum="71B099174C9BA3C3" modified="2015-05-27" version="1">MILHIVLIFISDLVHTSADICSYCSCNEDKKSITCSSPSLLVRTVSLLPWIEEVHLINLNLPYPPHFLFHPNLKALYINRCGLEELSAHSLLPLPNLEVLDFADNHLKTLPATLLHSLKHLRVLNLARNKITDLSELSDMLAKNIVLEKLDLSGNPIALSNTNSFFPPSQQLFLSNANLAFLNSTALIFQPSTICSEDVSCRILPISQAQLGRLNRLDVSGNNLIVDISALNALSHAHLLDFSHNHLPSQFIDWLENKSRVKYLNLSNAEMHLHDDVWSSCGTDLKQLDISGLRRNNQICSQLCSEYCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPM0</accession>
    <name>A0A0D8XPM0_DICVI</name>
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        <submittedName>
            <fullName evidence="6">ML domain protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07439</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716350">
        <property type="protein sequence ID" value="KJH46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336086" evidence="4">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="158" mass="18008" checksum="80AA6D05BFFECA1F" modified="2015-05-27" version="1">MLILLLFVEVFCFIVLATGSQFQDIGYKDCKSQFKILEVKASECHLKDTPHGKKLCEFKDGSMPKIRIKFIPNETVSNLKTQIKAKIGQTFLEFPMADDDACTYGVKCPVEEGKETVYEKSIEIISNYPKNETVQVNWMVNKDDSKKICLIFLARIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPZ2</accession>
    <name>A0A0D8XPZ2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716382">
        <property type="protein sequence ID" value="KJH45859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPZ2"/>
    <dbReference type="STRING" id="29172.A0A0D8XPZ2"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH45859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32102" checksum="6D130662772AB096" modified="2015-05-27" version="1">MSESSGRALALAVCILMVITGSLNTIFAKWADMLKYEGVTFNHPILQAICMFFGEFLCLVVFFVIHVYRKYRWNKANISGELGSIVDITSDSEPTLPKFNPFVFLLPACCDILATSIMYVGLNLTTASSFQMLRGAVIVFTGLLSVGLLGARIQGYKWVGMLFVILGLVVVGVTDMFYHNNPVDDKNAIMTGNLLIIMAQIIVAIQMVYEQKYLIQYDVPALFAVGLEGLFGMTILCILLAPMYYIHVPRTFSTNPEGRLESRYFLRLERNLWSALDRSRIIRNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR66</accession>
    <name>A0A0D8XR66_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH47010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR66"/>
    <dbReference type="STRING" id="29172.A0A0D8XR66"/>
    <dbReference type="OrthoDB" id="5957665at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF5">
        <property type="entry name" value="PROTEIN EXPANDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="15059" checksum="E93142C5693A24DD" modified="2015-05-27" version="1">MESSCSTPGSSRSRSMAGLSLPLHLQQPSSSNSGPAVISPSVHNVRPGQMYVTVQTLTKENLVIVVNQKTKVHDVLWKCGEILEITEDKLFGLALRQPTEGIGGDQPRHEYFFLDPAQKIVKYAPKQPRFSQWVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRP0</accession>
    <name>A0A0D8XRP0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase ASHI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716313">
        <property type="protein sequence ID" value="KJH47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRP0"/>
    <dbReference type="STRING" id="29172.A0A0D8XRP0"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="172" mass="20267" checksum="57C334F5EE3FA99E" modified="2015-05-27" version="1">MLRKLSQRSFHTSRILSMRGPLTFPGWYPRDHKPGPYPVTDEERRAAAMKYGLRPEDYKPIDQDDVVRYAGDYPDFGIVTYLHKDPYESWTDRLNRRNWGEMVSMDMMRHRGDRMSFTGLDEDDFTLVRTIIIFMKVLVPMGLIMWYCSDADPSALHWKNPSVGYTPFAVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRR8</accession>
    <name>A0A0D8XRR8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716352">
        <property type="protein sequence ID" value="KJH46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XRR8"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="10">
        <location>
            <begin position="1428"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1573" mass="174366" checksum="0A9E16E4F9CF3A3E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRU0</accession>
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        <recommendedName>
            <fullName evidence="9">dihydropyrimidinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_06674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="9"/>
    <dbReference type="EMBL" id="KN716316">
        <property type="protein sequence ID" value="KJH47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XRU0"/>
    <dbReference type="MEROPS" id="M38.973"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydropyrimidinase like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="50"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="570" mass="62965" checksum="4C6BBC938608B2E7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSU0</accession>
    <name>A0A0D8XSU0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716408">
        <property type="protein sequence ID" value="KJH45446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSU0"/>
    <dbReference type="STRING" id="29172.A0A0D8XSU0"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:helicase activity"/>
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    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="287"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="435" mass="49745" checksum="9DCF2B6D5A47CC48" modified="2015-05-27" version="1">MSARGSLKLSINLNRGISSTSECNRIISDEKEDEFLREESSDTNKSSMGMSGLLNVRIPTGTKAQKRKHIQTNFDNMLVNESSLDAQRKEKARLERLERQKKAFGETDHIQQVAAMLPKSVAPLPVLDVFEPEVICLIGDSPHQQVDSKKNCSFSDGTCKSTASVSKVEPEIIELSSGDEDEKNDCHDHTQQILPYRVISDQDGCFREEKSCEIPYEMKIHVLQIDQENMEKQHQMERQRMKKIRNSHDLEKIELTTTGRLLVNAGHGPEDPDVHVCPHLTHILQPHQLGGVRFMYDNIIESLSEFDTSPGFGCILAHSMGLGKTIQVITFIEVFLRVTRAKKVLIIVPINTIQNWMNEFEKWTPRLLKTGEYGRHFEVFLLGDSVKTFDRRLNLIEEWSRRGGVLLIGYEMFRLLIRTTQPKKSRKPKPKNTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSX3</accession>
    <name>A0A0D8XSX3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716328">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336174" evidence="1">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="27329" checksum="4CB4ED7B14DFCC85" modified="2015-05-27" version="1">MLRLLFALTVPTTVYTAVQCYVGQKLFSYESNNAICARFIPYHCAAQCEWLTDERNRNKCTWRDTESIVILSPSIRTNPVLAPNHYIRDARMERDGKSRVDVTLEVCQYRTEREHCNLERMTEEERQSFESITQKLHRSEEIRTVQKSGDTLKTSSDDKTARDCVTLAKECEEEIKSRMRTCCHDKSRCDNACLKGIEKSLSEERTRKNKGCSVQEIQFGINCLSRKINNLILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTG9</accession>
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        <recommendedName>
            <fullName evidence="1">CC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716292">
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    </dbReference>
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        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150">
        <property type="entry name" value="PROTEIN CBG08832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34150:SF7">
        <property type="entry name" value="PROTEIN CBG10108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04942">
        <property type="entry name" value="CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CC" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="643" mass="66868" checksum="8B1F3271B81FF70B" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU63</accession>
    <name>A0A0D8XU63_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_06557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716311">
        <property type="protein sequence ID" value="KJH47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XU63"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF7">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="268" mass="30297" checksum="E6B6AB52F7EFFDF7" modified="2015-05-27" version="1">MRYVGVCHPFRAKRWVSGTPVKCAIAGSILFSILSNIHTWLELDISECFSREFNQNVRSVKLTPLKSDHTYNFITRCILYTLLMFVIPFVILIIVNWRIIVALKNSTRMRRGLSTTKFTQSRILHNFRLLKNAKYSEVFGKFGQLGFSPLRGGSSKSSSVRDRSVTNMLLAIVAIFLCCNSLAFCNNIYEIVRDNSNHIETNSTQSVSTEVDNKSDTVMQNQNIFDFSVELSNILISLNSSSSIFLKISSSNEILVEFGGTEEGTVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUA6</accession>
    <name>A0A0D8XUA6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_05748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XUA6"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="14">
        <location>
            <begin position="196"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="493"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="15">
        <location>
            <begin position="996"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136464" checksum="0A4BC49E7E11D791" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUM3</accession>
    <name>A0A0D8XUM3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_06373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716303">
        <property type="protein sequence ID" value="KJH47532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUM3"/>
    <dbReference type="STRING" id="29172.A0A0D8XUM3"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF167"/>
    </dbReference>
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        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="93" mass="9887" checksum="F27F284B39CCDB39" modified="2015-05-27" version="1">MKCVYLVSLKTIQMSQQRGAITLHRNGTIALRILAKPGAKSTAITDVGEDGIGVAIGAPPREGEANEELVSFIGKILDLKKSEIALDKVSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVH0</accession>
    <name>A0A0D8XVH0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, REG-2-like, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_06099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <source>
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        </source>
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        <source>
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    </evidence>
    <sequence length="259" mass="29056" checksum="E307030A996616A7" modified="2015-05-27" version="1">MACSMREISRTLHRFYTSFNISKSTNSVKVVSFDVMDTIIAMNEPFNVVYSRVANTYGFPVDPSLVAVTFPKYMRTLSATHPCFGFHSIGYFEWWKRVVLGCLEEAIGESIPREKAVDIAKDLFEFYATANAWHIVDPKLEAVINNIRWSGISVVIVSNFDGRLKKILQELDLYSLFDFIVASGEVGVEKPSPNIFRLVTNHYQLLSSSELLHIGDSVENDYLAAKNFGANALLFDPSSLNNDVSKADKISSFSQLTVP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KJH47934.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23615" checksum="1ED999B3050DE5EA" modified="2015-05-27" version="1">MGQRIVGVNGVLVYPNTPHKEVVAQIKRSPLCTTLLVASENVDKWYKENNAEYSFDYIEDDNLRNKQISPHSIHISDDEEILQHQHGLQRQSNEEVECIEIEEIHEPGDFQHEHKIALSQQESQRHHVNHVPTCGLNRKDNEQSSSSSILNGFETSVDGGSRTIDNCDIFGLSAQEAREKLRLNKKDIHRGFDMSLEEKFRLVSNM</sequence>
</entry>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716286">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH47969.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15377" checksum="6E200C819C9C8BBB" modified="2015-05-27" version="1">MKGKTIMLFQMSSFRNPTCIFVGKKSYSFRARQDQTRTSEESTASYYKNAGPTLHTLPVRLQSSKIGRRLDEEQSREQAGFRKRFSTMDHIHTITRLIEVSREYKKPLCLTFIDLKKAFDSVETGAVMEVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWA0</accession>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716256">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="235" mass="27141" checksum="4C034AC55B44DDAC" modified="2015-05-27" version="1">MMWFEYITVPCPFLSNSASSRFCKRRSLQSHTFVMLSIVMKVETFQEHDDDDRDSLGGDMDRMLRDYPTTLTTFETTAIEPDGTVQTISRRVETRVRDPILSHVTFTGTESEERVRDLPMEEQFETVDAEGNITRTVCRRRSPPQPHINSRVRLQKEQRISAIKRYRFNKISSSTKQTTPPSLVMGVARRQNFHIKLIVIFVGCNFMKSNIIKQSPMMKSPMSVKNGQALLTSRL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48229.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="101" mass="10948" checksum="1FE33250A650426D" modified="2015-05-27" version="1">MVEFSVLGKLHHIASRITSSPITIAISTTTATASATAGAVYMKQFLVLLLLFFTISVVLPSPPPLATRLRPRRNMEALERIMKEMLEIGAVANGPGFRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XX08_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_04829</name>
    </gene>
    <organism evidence="12 13">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="KJH49050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="von Willebrand factor A domain containing 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="22"/>
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        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="Nephronectin_domain"/>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XXB2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Unspecific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_05519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716269">
        <property type="protein sequence ID" value="KJH48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXB2"/>
    <dbReference type="STRING" id="29172.A0A0D8XXB2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH48404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="500" mass="57434" checksum="17DFA4871053E28D" modified="2015-05-27" version="1">MMRRFAYSLLMNCGFPVLPSPYFISENIDVFLSPTAIFTFGKLAKQYGPVFGVMQGGVPTIVTSDVDVIRDICQKNFSYFHAKIPTLLDPDPVLDENVHMFASRGARWKRLRYITSQAMSVKNMKKIFPMVEESVNSFMKLLNHIPPGAPIEVHKLFQNHTSDVLARCAFGQSQSLHHNNLYHKFFSRAFGNEMKNSYFCWNTASLCFPSLAGVFREVKKFCEIIRDTTFGTASPLLIFSNHLAALRFGRQPHDENNDFLQYFKNVEDNSFNGFLNEKVSGKVDFNSIRISKSMAPGETVAQCRFISIAGFDTTANSLALACDLLAKNEAKQEFLLREIDTIETFTYDNIQSMKYLHNCILETLRLYPHASMLQHRLCMEDCQIGPYTFRKGVGVVIDTWAVHHNLKIWGADVEEFKPESTRQNFNHRQSNKLNAFMPFGKGPRQCVGMRFALMEMKLTLSVLFTKYRLRKKDHNEKLSMTLRDTGTVWPKEVMIELEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XY98</accession>
    <name>A0A0D8XY98_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-independent organic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_05117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716256">
        <property type="protein sequence ID" value="KJH48792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XY98"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF151">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="462"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH48792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="692" mass="76921" checksum="4B97087FA39626D6" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYJ8</accession>
    <name>A0A0D8XYJ8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_04951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <end position="414"/>
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        </location>
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        <location>
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            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="46603" checksum="C16138703980B5D4" modified="2015-05-27" version="1">MRLISVTWLTVLFIENLNAQGYDTSSEIDTPLKDISGVIYPQNEVDPFWDNILKDGVDDWLSETLNDPKSAESENHSTTIKSATEISKKGTHSDEDTDDDTFWKTLIEKSINECVSKILQNSSNDTSTTSQTTKDPFWSTVFEKSINDWISKTLKDSDNNSSTTNPTTKDPFWSSIFEKGINDWITKTLEDSDNNSSTTNPTTKDPFWSSIFEKGINDWISKTLEDSDNNSSTTNPTTKVIKSISITLFSSWYYALFKDPFWSSIFEKGINDWISKTLEDSDNNSSTTNPTTKDPFWSSIFEKGINDWISKTLQDSDNNAATTNPTTKDPFWSSIFEKGINDWISKTLNDSDNNAPAINSTTKDPYLSSVIEKGINDWISQTLHDSDNDASSTIPSNTRDSTSVDTEPQPQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZA5</accession>
    <name>A0A0D8XZA5_DICVI</name>
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        <recommendedName>
            <fullName evidence="5 10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_03866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="141" mass="15966" checksum="A691DA26BB70E0D7" modified="2015-05-27" version="1">MDVENVDIEEISSLSRHQSANKCVTADIIPIEPISTFYSKRLSDIKHPMRVALHGKLSVKKRCAKRYEISKQAIRRLAGTVGVNRLHSGVYDLSLRVLETFLEDVLADAITYSSGAERKTVRVEDIQHALLRRGIRIYGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZT4</accession>
    <name>A0A0D8XZT4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZT4"/>
    <dbReference type="OrthoDB" id="5831355at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401:SF1">
        <property type="entry name" value="DUF19 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34401">
        <property type="entry name" value="PROTEIN CBG12388-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="130" mass="14594" checksum="55873309A7571D4A" modified="2015-05-27" version="1">MKARLTHVKTYDYPDMIKRVENLINEQIQTFLNSVTSNNMKKIFVKQVVSAAASVARCVKDCFIEKNKDGYCFDKKGGEPNIADRNAKLAIRQCSRIVNWKKEIGELCTCSSKAGVNGISDYCGMMNIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y013</accession>
    <name>A0A0D8Y013_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_05956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716287">
        <property type="protein sequence ID" value="KJH47936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="9">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH47936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17271" checksum="C219FD5F5E4EE7B3" modified="2015-05-27" version="1">MIEGRRVFFLTPLLANLCTGADDEENGRCTRLGEPRSGNIIVETNFRLYAYTSSVLQLAILSTFTEMIYRFNDMSVGITASQIISFLKANAHQECLNTGGPLNSLPITVADQIRLWEDERRRMTFTEATLYSTFEDGSEFVGKLMERCFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0D6</accession>
    <name>A0A0D8Y0D6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0D6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0D6"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="576" mass="64596" checksum="F66D5031F07E8926" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0F2</accession>
    <name>A0A0D8Y0F2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_05792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716280">
        <property type="protein sequence ID" value="KJH48086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0F2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0F2"/>
    <dbReference type="OrthoDB" id="5831108at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="32473" checksum="9FC71973B061F4F8" modified="2015-05-27" version="1">MSSAKKRCRIDSDDEVPCRSDRGINGEDEPDEYDDGDELCHGKDDIIEPHIMLEYVKDFRQFVTEKGKLYITVSRMKGLFGEWLAYRQKDSPTHDLETILKSFKRYVTASVKPVYLSMDCCFRSVSEYLSRPESVLMYPDFPEVIHKMQEDNEGRQECERELCELEKAFLKKMEDFLVNNHEVMLPNQTKYVQHRIHLTRKKLFPSERSIKARQATAMNGSEPKQEKTAFDLFCSTKMDKYVELPAEVRLRKLRKKFEKLSEDKREIFEKLALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0Z7</accession>
    <name>A0A0D8Y0Z7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutathione-disulfide reductase</fullName>
            <ecNumber evidence="5">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_05633</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="KN716273">
        <property type="protein sequence ID" value="KJH48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0Z7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0Z7"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
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            <end position="191"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="681" mass="75001" checksum="0BDC0A0AC62E44CF" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y135</accession>
    <name>A0A0D8Y135_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neurofascin/L1/NrCAM C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716221">
        <property type="protein sequence ID" value="KJH49857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y135"/>
    <dbReference type="STRING" id="29172.A0A0D8Y135"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336386" description="Neurofascin/L1/NrCAM C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Neurofascin/L1/NrCAM C-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="12967" checksum="92B5E863CA30C992" modified="2015-05-27" version="1">MLILLILLLLICILCMVCVALRHRGQNYPVSQKEREQGREPILGKQHFGEYRNDEDEKRSLTGSKAESETDSMAEYGDTDPGRFTEDGSFIGQYVPAKTLMPPERPEKGSTSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1D6</accession>
    <name>A0A0D8Y1D6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716204">
        <property type="protein sequence ID" value="KJH50500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y1D6"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="498" mass="57339" checksum="E74E7D4516D542FE" modified="2015-05-27" version="1">MVSQSSRNTPNELLEPHPSQQPRKKAKRAANWVAQARSRATGTIRRTLFGQKSKSTRARDAESIIAEEDDYTQTNYDTVKSLPATGHYGRSRVGHHLYVDVEGHLGMVQHPFPFSAATPPVIILKLPKRRQSAQQSRISPMARTPFYDPVFDFQSWHSTLHEHCQDAVYSLFMKAHKCYDLIPTSTKLVVFDIQLPLRKAFFALVYNGVRAAPLWHSEKQQFVGMLTITDFIKILIKHYEAGDKDEKMHALEEDQISHWREQFEAEGVRPLVTIEPSDRLAHLLISENPSLIFQFSLFRAVQVLCESKVHRLPVMDKNTGNISYIITHKRLIKFLSLYLHDLPQPAFMEKTPKELGIGSWSDIVTIHVDTPLYEALETFLRNRVSALPLVDENGRVVDIYAKFDVISLAAEKSYDKLDCTVQEALKHRSEWFEGVQCCRDTDSLFAVLENIVRAEVHRLVVTDVDKKFLEIFNINTECRNVEMIHIVIYHLRCLMEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1L8</accession>
    <name>A0A0D8Y1L8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KN716216">
        <property type="protein sequence ID" value="KJH50057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1L8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1L8"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336113" description="UDP-N-acetylglucosamine diphosphorylase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH50057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="395" mass="44014" checksum="1C085202497B4658" modified="2015-05-27" version="1">MAHSMKVKKLTCLLSITWLSQQFIYTQPTKLPPLASTIPLGLNVAPCDSLLGIQASKIALLEKLATMEFPQNKETTKIQWLVSTDQATRRHLEEVVPAAGLTFEQITIFSQAEIPAFDNEGNMLLSNKHTIVTAPNGNGGLYSALATYLPIMKSRGVKYFHVYCVDNILCKVADPHFIGFFIEKQADVATKTVLKKPGELVGSVCMDNGRPRVTEYSELGSELAEQKASDGRLVFRAGSIANHLFSLDFLESFCDDHFDLPYHRALKKINYVSSNGALVKPTSPNGIKLEQFVFDVFERSSVNFICVQTILDHRNFYIWEVVREDEFSPLKNDDSVGKECLSSCKRDLALLNKKWLTAAGAKVEVEPIYLNTFLSYCGEGLDRFKGQTISGPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1N5</accession>
    <name>A0A0D8Y1N5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptophysin / synaptoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_03906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1N5"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF52">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH49959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19352" checksum="11B8737CF77CCCD0" modified="2015-05-27" version="1">MLRSEEELAQTTVDLGPTKQIQQSDGFVKQPTSQILGFIAFILAICADRRSTTAAWTEHITFETTIVVSALLAGYVCFPHLTIREEPTREGLIVLELIFYGINTLFYFISIWLMVHLSASWGTDGRGAAIMTAIICVSLTIIFAIETFLKLKAWRGENEPSIKVINTVPQPSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y250</accession>
    <name>A0A0D8Y250_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_03107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y250"/>
    <dbReference type="STRING" id="29172.A0A0D8Y250"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FPNCR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH50760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="650" mass="74216" checksum="43429950B6110B7D" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8Y369</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
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    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y369"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KJH51160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8404" checksum="85D1A10676A73F36" modified="2015-05-27" version="1">MLNFDVDVDAIEYPKMGDPVSLGMVVIRGNSVVIMEPKERISCSIYYLLWSSNLLRMQGGCDVTKYRGQLPYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3A3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="515" mass="57056" checksum="10AB60303E29CA07" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y425</accession>
    <name>A0A0D8Y425_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_04575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KN716239">
        <property type="protein sequence ID" value="KJH49311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y425"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
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        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH49311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="359" mass="41756" checksum="3B33F129A50E5583" modified="2015-05-27" version="1">MMYDDIANNKLNPYPGKLFNEPDGEDLYKGLKIDYKKSSVTPQNFLNILKGNATGVRGGNGRVIESNPNDRIFVYFTDHGAVGMISFPEDMITVKQLNNALNWMYRNDRYNQLVFYLESCESGSMFEDVLKSSISVYAVTAANAHESSWGTYCTNDMHLPCLGDLFSINWMKNSDKEHINDETLEDQYDKVKRVTNLSHVMHFGDLDIAKEPVGWFQGMGNPRRKYVAKEPHRADSWPSRDVELSYLYQLKHTTNDVTVIKKLNQRIREIQKDRHRIKSLFFKLVNKLITDPNDRQRMVQQHKSVEDIDCHDEVIRMFDLLCIDLNKYDYALKYVYVLNNLCIELGNTEEIVNAMWKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4M5</accession>
    <name>A0A0D8Y4M5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716232">
        <property type="protein sequence ID" value="KJH49521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4M5"/>
    <dbReference type="OrthoDB" id="5777712at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF6">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41362" checksum="0E703EBB17DEEA0E" modified="2015-05-27" version="1">MHLTKIDGDEDLRIHNISILPSDQCATEDQRAAKCCCGDGFFFDFPRKKCEVSLNVGFMFGRINNGWSHVVVYGFVYPVLLVTLVAPLCAVMLGMGKREKREGDRRYPNPLHQMIWLLAFCGWVSVLSPLPFTFWYYILGEGTRSLNQSVVMCHVYRTTMEAIPHTIDTMMTLFSVLLAAARFLTQYHRSTLKLRTVERFSRAIWLIIFVCFAIGLLRFFEHDTTVYQFCMDTEPTPQWAARCMLRDGALMNILTRTFWKKKKVIHVILVMVLALLIGHLQPLLSITTIAANSTALLTAYYVIVKDDDDDVGDSRNSLSETEEPHEMLLRLERERRRTRYEVVNDLHIRLGHRLESQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Y6</accession>
    <name>A0A0D8Y4Y6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Y6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Y6"/>
    <dbReference type="OrthoDB" id="5871897at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="31107" checksum="2450A37AD9B937FB" modified="2015-05-27" version="1">MKRPKESKKLIGRNKFCAINIKLTSNFLGNEHFLAAHRAHIDELLEQLADDECTDLENDDVEDLHYCVVCDKTFKTMNAQINHENSKQHRKQLAELKRHMKAEDHALFEKIGCNAESSSRKGVCKSERANRKVEKKKSSKEDCDQDLVDIEKRRIEAQCSDDLDVLDNLNKKLTDFSMMDADDRRVEKTMISATEKGIEKKKKKGNKKNTDVRNVVSSASGGNAPKIAVCDKCKEIFESRTKLFEHLKLTGHATIKASSVPQPSHKNRKDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Z3</accession>
    <name>A0A0D8Y4Z3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">DICVIV_02746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Z3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Z3"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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    </evidence>
    <sequence length="96" mass="10808" checksum="22C56700885B1D08" modified="2015-05-27" version="1">MPYICVATMETAMLNGYMWMYASDHSWGLDFAPLVDHVVAVVRGCCILLGIAIRAYLFDQIRPTRTRDATEIYEVDTVIAMDADDDSPIIFDLARS</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <ligand>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34339" checksum="3C7BE05A747E29E2" modified="2015-05-27" version="1">MLTSAEIPQLLKRNHIIKGYRPLNQPVFYYYKSAFFTHNELINVWTHFVPVVYLSAFYFLPELLSSAPRLPILVLYSGVIMLLLASSFAHLLHSRSLHDHIFWFLIDFSGIALFGCSIGLQRYSCGSEMSLLGHMTYLLSLLFIALVLQFFSSCYLLVCRPKWPWRDKLKMATCFCLAVWVYVPLLDRYLNEHSASDTSLILHTKAFHWLLISGIFMGGHVPERFAPGVFDIFGYGHQIFHLCINMVAWNICDAAHLDCAPIAWSSPPNLAIIVAFLISAIFIMFTVKKLSKKAETIKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y636</accession>
    <name>A0A0D8Y636_DICVI</name>
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        <submittedName>
            <fullName evidence="7">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y636"/>
    <dbReference type="STRING" id="29172.A0A0D8Y636"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000026">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF381">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="604" mass="70231" checksum="7A6B4FE4F8CCE64C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6F2</accession>
    <name>A0A0D8Y6F2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_01497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716167">
        <property type="protein sequence ID" value="KJH52295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6F2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="136" mass="16084" checksum="04E66DCF6F937036" modified="2015-05-27" version="1">MKLTAGWHRRRVVAETKSSSSCPRRRRDVARRRDALSMVQQCNHRCIFLTPTSPHLKYFEDFFYKESINNPQKDMLDSLHEHNVIALSFFRRYHRCLMLRHLLTETPDMNVPNNSGLKEKKTQQFTSDVGRHGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7P5</accession>
    <name>A0A0D8Y7P5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_03218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716201">
        <property type="protein sequence ID" value="KJH50626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7P5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y7P5"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="254" mass="28718" checksum="BC121C08D2B68EA9" modified="2015-05-27" version="1">MIYVKGEKLHRRKLDEKLKLMGASIYRLEAVAALLSHEYVLVDLRTSSSCNKMTPLMFLNLSDLLYQKINLCKFVRCTKATTFAADIHQNKIPNSATEQQAAARRTVNPSKLQSIWHQQLQSIWHQQIACGLGYLPIAEYLIEKGADIEVKDSKKRTALSHAVLNGQEHSVAMLLSRGADLIKGDSSGNTPAHYASAYGWLGCLRLLATVDPTCLKQENDWKLTPLSVAYMKEKYECVKYCEEIVVRLKIKKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y895</accession>
    <name>A0A0D8Y895_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_01399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KN716165">
        <property type="protein sequence ID" value="KJH52422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8Y895"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AGC-kinase_C"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="602"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
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        <location>
            <position position="641"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH52422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122279" checksum="A3F9BACB7062ABA5" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8Z0</accession>
    <name>A0A0D8Y8Z0_DICVI</name>
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        </submittedName>
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    <organism evidence="1 2">
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        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716164">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="134" mass="15758" checksum="85C00EB9D5D9CE9A" modified="2015-05-27" version="1">MWKFAFRHTKRYSGPILSRPDVAKFLTVGLQKGRVFFRNTVISVSTSWKSVSLSDLRTQKIVEEQVESRNSDKMDEAKIRSPTFPVRTSPRITDFFLEIWEDNEHQYAGYQRPVGRMMLELRTLSDAPKLYRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAY1</accession>
    <name>A0A0D8YAY1_DICVI</name>
    <protein>
        <submittedName>
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    <gene>
        <name evidence="8" type="ORF">DICVIV_00667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAY1"/>
    <dbReference type="STRING" id="29172.A0A0D8YAY1"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH53169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="45860" checksum="A888CDB6EC355297" modified="2015-05-27" version="1">MYIAFTHILSSRRLLPQNVFKKRNIDGNDRCVEGYLRAYVMDTKEILGARLVQKFKGVTTAVEQRYLRELILVVSPTNEDMNDAIEMYTWTMRYDIDGDPQAELRRADGTVMAALRFRGMQYLKKQTAELLRMIRALCRDTLAPLPTGASAVIRITYTDRTPKGYQAPGFYRSPEEPVLRSDAQEIEIGSIQTKYYGASVVIRSLFIDDAYAVGLRLKEAIKIGSLDDSLNDSFGEEADASDEANRSNNNDTMERISDTALHQSGDVEVAREGAECVDETRSRSTPVISDSETSKLTKLSVAVDRGSIADMDSLDASLPTEEYPKRSRRGRPAAVKSARGQPVFERSRSPVSVSVAAPQIVHVTTPTTKPSNDSCDTPPAKKTPGFIKLLQRSHQQSGGNNKQLAHMLLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEX4</accession>
    <name>A0A0D8YEX4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutS domain III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716155">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEX4"/>
    <dbReference type="STRING" id="29172.A0A0D8YEX4"/>
    <dbReference type="OrthoDB" id="5868336at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="219" mass="24813" checksum="12E7E1B587CC33C2" modified="2015-05-27" version="1">MLGHGARNSLLTVVDETLTSGGSRLLRSILLQPSGDQDVIEHRLDAVEELINNAHLVDKLRDLLSTTYDLEHFFNVFVESPHVSTVQTADFNVTQLLRLKQILNIVPHLRQITKNFKCDLMSIKCKEGVSVNLDIARRAYGELLRDIECQEEELSTHLPGKNTRLAFSTARGFHYVWVCGEAGSVELPPIFINVVRNRSSVTFTSRNLLRYNGRLQFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFB8</accession>
    <name>A0A0D8YFB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716153">
        <property type="protein sequence ID" value="KJH53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFB8"/>
    <dbReference type="STRING" id="29172.A0A0D8YFB8"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18023" checksum="D57518A13AC4AC82" modified="2015-05-27" version="1">MYLFLYLGSGALLEATRSDAIRIVNFLHDRGAVDTDNRALRLAVKNKNFKLVRVFLTRLVFPDPEFKVNKKNVDVGQVKVYFHSSYKPIECNNIIEYDILSPSESLPIHVGSNLLPSSLCPSRAAMLNWSSASLRVLQSDWFIAAALQINPRLRTTKCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YFU8</accession>
    <name>A0A0D8YFU8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_00271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YFU8"/>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF1">
        <property type="entry name" value="PROTEIN SALIVARY GLANDS MARRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH53526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="273" mass="31734" checksum="00ACAD8FDA669728" modified="2015-05-27" version="1">MTITLCHSIASLYSRRSDSDVWKKYCNVYDEGGDELYRHIKNYASYTYLTQSFLNLYFDEYHVHFVTELLVRPSVMQRYTSRVFGNKTNFIGDRSEQDGNFSATSFTMKAQKKIASKLSTRKVTKLFLSDDIDRIFESLYSVLRTYYSKNDAEKVVKNVIKLSVKMALLARNDLLSQSDRKQLTVVQKQLHSLTLTIISFVQSGKLSREYLEKIRERKAQIRLNIKYSFERSHLIEKMRNIQQSLAPLIGGPHAEILSKFASTLEESLESEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X651</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="2">HannoverDv2000</strain>
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</entry>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    <feature type="domain" description="SecA Wing/Scaffold" evidence="1">
        <location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07516"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="251" mass="29562" checksum="70FC298C4680CB5D" modified="2015-05-27" version="1">MKAGEQIISYVVTLVVRKVGLKNNEAIHHLWINKALEKAQKKVEARNYDVRKSLLNEVNESLIESIVHSGCYEDYVEDIAKEFHTKYGMILDREDLAKFVNKQEALDYVNDKVQGFFTERERYFNSQQTTNLWNTVVKQVMIMTLDHLWREHFSILECLRQSINLRAMGQKDPLSEFKREAFLMFESVLKKWKELTVHRLAYFKLVDNQEIGNRLYSTERGNSSKVSRNDKYPCNYGKKYKHCHGAITVVN</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
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    </evidence>
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    <sequence length="115" mass="13178" checksum="7614433229A46C7F" modified="2015-05-27" version="1" fragment="single">MPSQISLMPMHNAFLLSAPVVPANINYAVSAVKCFTRALQLAPGSRLEDTLRLLQLWFDYGEYNEVYQQLSENMKGLAIETWLEASMVSEELVRCAILWYEQWHDALDEASGQYF</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <begin position="20"/>
            <end position="80"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8231" checksum="C9CC860E5C2B8786" modified="2015-05-27" version="1">MAIIIAMTLLAICSNSIQTQFQSCASEGAIGPCLSGLCPLSTASCITTSSGDNVCCELTKIINHTTATPSDTITDRHVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN717206">
        <property type="protein sequence ID" value="KJH40450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7C6"/>
    <dbReference type="STRING" id="29172.A0A0D8X7C6"/>
    <dbReference type="OrthoDB" id="7754674at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH40450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="266" mass="29642" checksum="70912894139DE1C3" modified="2015-05-27" version="1">MFSAKNGILRSLGGVKVPDREYSWAVGLIALLEKYLCSAALVSTRHVLTAAHCVSTYKKIPKSGSSKCSELHVYPEVKMTIHSDFDPCNSTGDIALLGISPNMLTEALPICVPLENETIPAILTATGFETNLDLPEGTGYLKAVNLTFKTENKEKIVTLTFEKYLALKIVVGQFPNEMARGTLFWKFPRELKAVTKIRKGLHTVFLGRLSPTLPNKRPFHRCFPFNLVSWGLATEMIPEFSTTKKTIGWFKDVYSKIDWISHNSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7N5</accession>
    <name>A0A0D8X7N5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722309">
        <property type="protein sequence ID" value="KJH39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7N5"/>
    <dbReference type="STRING" id="29172.A0A0D8X7N5"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="40" mass="4736" checksum="845178CAFEC22CB8" modified="2015-05-27" version="1">MLKDMISRSHDLDVPSLWLVNTWSLFNLLWQYCGEKAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7R5</accession>
    <name>A0A0D8X7R5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_13449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KN717097">
        <property type="protein sequence ID" value="KJH40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7R5"/>
    <dbReference type="STRING" id="29172.A0A0D8X7R5"/>
    <dbReference type="OrthoDB" id="1845775at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="10">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH40588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="123" mass="13376" checksum="F68906291812395D" modified="2015-05-27" version="1">MVAKLISGTEISKQVLDEVAEQLKLTKSNCPSFSVVLAIVQVGNRPDSNVYIGAKIKKAAEIGAEGRLVKLPDTITQPELEAEVEKLNVDDDVDGIIVQLPLDCRNTIDVDGVIDRIHPIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X839</accession>
    <name>A0A0D8X839_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB And Kelch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_14293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN720231">
        <property type="protein sequence ID" value="KJH39814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X839"/>
    <dbReference type="STRING" id="29172.A0A0D8X839"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF480">
        <property type="entry name" value="KELCH-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH39814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="127" mass="15039" checksum="3CDA348A9680324F" modified="2015-05-27" version="1" fragment="single">MAGLTIMDSVCYACQQFMTQLLTIKNCLLIRQFAEQHNCVDLLNSSDDYAIDHFMELRKMDEFKQIAFPHLRDLIKRSDLKITNEEQVFETVIEWTETNPTERKKHLPELLSLVRLPQLSMQYLMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8J0</accession>
    <name>A0A0D8X8J0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_13152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KN716984">
        <property type="protein sequence ID" value="KJH40885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8J0"/>
    <dbReference type="STRING" id="29172.A0A0D8X8J0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH40885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="391" mass="43235" checksum="143B58992A2F33A8" modified="2015-05-27" version="1">MTTLCETESAPLLRLRVSRGGLKHARLPTGYNEMIGDGPGSSIEEIPTFIRGSSPRSLDSSGAGSNTSGRVTSYSQHIDAWRSRRQDRELPSYDSELPEDSLSKEFNRVSFLRRSVCALRRSIGRRSRKKNTNDPAPHAYNSSRPWSIGESTKEPASSDVRPSRSNEKCEILPCGPVCVYSGFGRTFERINPGEEIAIAVFGKRGVGKTSLLDHATLLCEGQHGIAPLGLTERMRLGGKQNHMEYRFAHMTSMTVQTSKQLFVIDLIDAEFEDDHSVTHTSYMRAVDAVILLYSCSDSASLLTAMSIHRQLATVAESRKPCVLLANVIHGALQRYVTREMGEKTARNIRAVYVEADLLVQEGSVSMAIEYLCRAVVTARKSTDVKDICSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8M6</accession>
    <name>A0A0D8X8M6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716966">
        <property type="protein sequence ID" value="KJH40925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8M6"/>
    <dbReference type="STRING" id="29172.A0A0D8X8M6"/>
    <dbReference type="OrthoDB" id="5854247at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335577" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9454" checksum="0869E9B34D74342D" modified="2015-05-27" version="1">MNQRLRTISILKCVLLVFVFNANSLTIRGGETRWQLFNQCSKAMLQTYLGHVNTRGHSSRLCLITLVDLRLCSPSSNFHRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8P9</accession>
    <name>A0A0D8X8P9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717712">
        <property type="protein sequence ID" value="KJH40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8P9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="13273" checksum="23396EF70B1D1CF1" modified="2015-05-27" version="1">MHSFEIIYYYYRGVQFFLVIFNVLCFSRLFVVGNTFHYDQSQTATVARRAIEQELQEYEDIRNLIMATWSNQMWRTILNRVLRVLSSGPFGRDFQSASVDIQHHCKAPNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9C4</accession>
    <name>A0A0D8X9C4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716886">
        <property type="protein sequence ID" value="KJH41170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9C4"/>
    <dbReference type="STRING" id="29172.A0A0D8X9C4"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12568" checksum="5397CFDCD1419864" modified="2015-05-27" version="1">MKLQYLSTILPQQEGSNKICSLACTPNGVKLAIVARDRSITLVDEKGVVKDRFSSKPFDQKYGKKSYIIKSICFSPDSSKLAVAQTDNVVYVFRIGETWQVDCSFSDSFFLQ</sequence>
</entry>
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        <lineage>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="121" mass="14460" checksum="EC32E42267064E18" modified="2015-05-27" version="1">MSSKSGLTKNLDIRSGKRLISQRFYDRFTLYRIKSFLKIDKELVSTVTPYKENGTLKHRAKPYSEDYDIIYKNHPLIMMAKSEVLLSHRLVLALLRHKWNSLGRFVYYFVHNMLSYRVKEI</sequence>
</entry>
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    <accession>A0A0D8XAC5</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D8XAC5"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="79" mass="8803" checksum="1525C79BF7ED6FFF" modified="2015-05-27" version="1">MTKETRLVVVQQKSVVVIAHCDTYLSYNGFLQLMHKYFNGLNASSLGLLTLRSQSISELSDLIDNGRIFPARVISLSNS</sequence>
</entry>
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    <name>A0A0D8XBV4_DICVI</name>
    <protein>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH41144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
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</entry>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716881">
        <property type="protein sequence ID" value="KJH41199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC33"/>
    <dbReference type="STRING" id="29172.A0A0D8XC33"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15440" checksum="EB3D79F2C5687A61" modified="2015-05-27" version="1">MLGSGFIDGITGAKMSSQMSGFSSTQMQQGAGVVEWLLWSYVIQLSAALRAVHANGLASRCIDLSKILIHGKSKILLNCGGVTDLLAPDTQVQQLQMEDLHALGRVLLALATGNAFSARRDLVQQSMTYVSNHYSSDMKNLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCG7</accession>
    <name>A0A0D8XCG7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_12562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716819">
        <property type="protein sequence ID" value="KJH41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCG7"/>
    <dbReference type="STRING" id="29172.A0A0D8XCG7"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002639">
        <property type="entry name" value="Kruppel-Like Factor (Zinc finger protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF156">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="38837" checksum="34434A18B651DB91" modified="2015-05-27" version="1">MSIFQTPTFAKGVAVEDHNMKSAFAPVSPKKPSNHQYGMSASNKCGYRISDLLHDDPGFCKSSRDFMSRSKVHQVPIKLVQANANQDLTTCQSRNDFVMLSEQEENHEIEDHFMDSMTRSIAKPVETISFPLTINVNTKTTTPDIPTSASSSVNSYVYQCFNPETLQQQLEELTAASCRAVQPDEKGMMNSEKIRDQIAVVKRQLDIFQQLMADAKGELEMARMEEESQDSAAIDDICEPSPSSSNADSESPRDRRLHHCSHPHCGKVYTKSSHLKAHYRTHTGEKPYSCPWLNCEWRFARSDELTRHYRKHTGDRPFKCVQCSRAFSRSDHLSLHMKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCR2</accession>
    <name>A0A0D8XCR2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibrinogen beta and gamma chain, globular domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_11620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716671">
        <property type="protein sequence ID" value="KJH42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCR2"/>
    <dbReference type="STRING" id="29172.A0A0D8XCR2"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="519" mass="58601" checksum="8952B2F4B7A1495A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCS4</accession>
    <name>A0A0D8XCS4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716666">
        <property type="protein sequence ID" value="KJH42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCS4"/>
    <dbReference type="STRING" id="29172.A0A0D8XCS4"/>
    <dbReference type="OrthoDB" id="5838802at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="412" mass="46937" checksum="281FC81278B91D0F" modified="2015-05-27" version="1">MEAIHIASTPAELYNAVLVDTPLANYFVDCINEQDLDEMNVELIRNTLYKAYIEDFYKFCKKLGGTTAEQIKSRKAHIKQLNEGHFFISGEMVYTQNIGGIAILRLQPQRHKKINITNCYSPFDATDENKLEALYNGLEKLFKTKNSFSNDRKVPWKKEHDMMLGPTATHVTRLLSSQALEDFTTKAERIGINIMPYEIMQALAIPHNVTTVPSVMKYPSLSALEQTACLPLMNSHKSRPSFDGTKSQEHFLFVVIQRKKSCPFLSLFPLTICLNAICAIQGCGQIPQGPEFIKSNILTAAKNVAYNQSVFHNLHKKWQNKITIVKKKEFRWPGGTKVAKTAKEGKGGRKTEIDLDLHLIQKYGHYPIFLVLTSLLSYYMAECYFFNSRMRPISTGTRKYSPLTCPQIDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDB5</accession>
    <name>A0A0D8XDB5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_12278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716768">
        <property type="protein sequence ID" value="KJH41747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDB5"/>
    <dbReference type="STRING" id="29172.A0A0D8XDB5"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH41747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20236" checksum="E98BC9336E046A04" modified="2015-05-27" version="1">MVSSCAGCNRMKPWASAFMGMGAGLIYLGLSRFMVRIKVDDPLDAFAVHAGGGLWGLLSACIIAHDGIIYAIYDAIGNKHGSLSCRRAFAQLVWQIICAVAIIIWSLLWMLPVLLFLKKIGKLRVAAEVEINGLDIHKHGEAAYPSNAYGHGWDGYKHKNIESTRHTQCHWKFSALDECKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDF8</accession>
    <name>A0A0D8XDF8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716758">
        <property type="protein sequence ID" value="KJH41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDF8"/>
    <dbReference type="STRING" id="29172.A0A0D8XDF8"/>
    <dbReference type="OrthoDB" id="5775049at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF24">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="218"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="37530" checksum="DD45D8ECCB2EF53E" modified="2015-05-27" version="1">MALKGGSRPHKRRHGMSAQAKIHAETIAEFIMNNCNCGQSRMYAEHDMLMKTEKHVTLYNQFPTKNRMWSSVCFDENAVELKTNNKKEEKLDHDNTYINANILESPLGNFVLAQAPMANTLVEWYRMIWQLKISIIVCLLDPMQLPTSERYFQLKEGSHLKIKHRFYIRTISVREDDGLLVNYQLRITNKLSTDKSRTVYVIVRPTKPDCPIEPRKQLNLVAEVWATETASLSMEEDRDTSPILVHGFAGIGRTAAFVATTMLCKSLQLHGVMSPVEVWTRLNDVRHNSARERIHFISSIECALLFAYDIGLLTPNIKQLNEVNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDH1</accession>
    <name>A0A0D8XDH1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_12200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="EMBL" id="KN716753">
        <property type="protein sequence ID" value="KJH41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDH1"/>
    <dbReference type="STRING" id="29172.A0A0D8XDH1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF3">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="218" mass="25421" checksum="0F5BA666353E3EF7" modified="2015-05-27" version="1">MVTFSLKVRRNRSCLRPEISRTAHNMRLAGKGSSGGLYKAFLSNIAVSSTPVNFSLLPYENMIKSNYDRELQQILHESQVVPFADFDTANLNPSHSYRVTFSSTREWFTLGQRFGLMVDIRFFKGGMQRTAYHGIVPLMFQSCRLFLLPSELNVTDLESYRYDPIRDLQLRYLEFEKVFCTSKMYTGVCDPDSPEMKAWFLKKRWTKRLESYGKMILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDT5</accession>
    <name>A0A0D8XDT5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8117 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716624">
        <property type="protein sequence ID" value="KJH42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDT5"/>
    <dbReference type="OrthoDB" id="5804999at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058430">
        <property type="entry name" value="DUF8117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26431">
        <property type="entry name" value="DUF8117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8117" evidence="1">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="313" mass="36288" checksum="96AE229FA605CEA5" modified="2015-05-27" version="1">MTLTVSMEDMELFPKDSHLSTNPNSAPVDIHCFAQMHASLERLWWSRLVISVRGYVINYVQNDDETLFHTDDAFICIHRFLAEEKSDKVIAKQSCGRLIVFDYSVKNALIIKALSPFRRFISDLNTVVTYPIVSETLLALCSSQKLKNPFVSNDVGPAFTRIFGQPNIATYRVANGQKYAYIVFMGVLCILQKRWMAERKEGKSIRFETDPEWQPDDRVVLFQEFYKGNRTWVLLDFDRYILAQWRPRGSEVIFGARFLEKKMRAGMELCSWCGMIEQMQNQFSRYVNNKAVCSSQCLEMLLQDSDRSTNLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE49</accession>
    <name>A0A0D8XE49_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAN domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716718">
        <property type="protein sequence ID" value="KJH42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE49"/>
    <dbReference type="STRING" id="29172.A0A0D8XE49"/>
    <dbReference type="OrthoDB" id="5865284at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335698" description="PAN domain protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13261" checksum="51107E166B1953FF" modified="2015-05-27" version="1">MTTVIDLFCSYSLILVLLLRAVPAIDIFCGTLSIFEQQQFGSNSVAISSHETVDLKQCLELCCSHYNCYGVTFTGVIAPHVGEPNCHLIGCGEGRCEMNERGEYPDGLLSVLINRTQVILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEG3</accession>
    <name>A0A0D8XEG3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717008">
        <property type="protein sequence ID" value="KJH40806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEG3"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="63" mass="7528" checksum="EA8BC9C0909A5EE1" modified="2015-05-27" version="1" fragment="single">MNLHEYLDVIQKNSSVRSSYVNTDVHFIKGVLYLKYTTKIMRKNQMIKKQNCAYRNRVSRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEN8</accession>
    <name>A0A0D8XEN8_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">Ribosomal RNA-processing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_11870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716704">
        <property type="protein sequence ID" value="KJH42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XEN8"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by glucose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH42139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="958" mass="108572" checksum="39FC58D1120F382C" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEV9</accession>
    <name>A0A0D8XEV9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716588">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384586" evidence="2">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24696" checksum="BA5A55F145C390B6" modified="2015-05-27" version="1">MMIVLFSIIFSVTRCEQTKSTTKTEVSEQIDPSIYVRQNLFGSGQDLYSNQGGATMPGDFAFTCKCTAKLPSPIPSIVTPTDANQIAQQQIQQLQEQVRRQQEVINRANQQKNGVEQFTQIMQLANSMECSCQNDEAGWKDRSVQPYGTSNFVRGNGITGFPTYPGHLRSEAFRGYPAGAQYIDASSGLPIEYGQYGQRGVPLTVPFQTRLQPILKHRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFI0</accession>
    <name>A0A0D8XFI0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="EMBL" id="KN716569">
        <property type="protein sequence ID" value="KJH43338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFI0"/>
    <dbReference type="STRING" id="29172.A0A0D8XFI0"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000064">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="6">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="415"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="561" mass="63273" checksum="A2DECE135E34DE5F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH16</accession>
    <name>A0A0D8XH16_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716518">
        <property type="protein sequence ID" value="KJH43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH16"/>
    <dbReference type="STRING" id="29172.A0A0D8XH16"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14258" checksum="2B093182898B64E4" modified="2015-05-27" version="1">MIPFTVYGGAAAARLILIDIVKREDLIGVLSPNDVVLKIEDVQVSGMLRSEVTRLIEKLCNENDQLAVEIVPAECQPHHQCVLFYLVSLCEVLNSSFDESNMSIFASSTYLKSCGSQTDVHHNSFLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH47</accession>
    <name>A0A0D8XH47_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Myosin head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_10917</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716595">
        <property type="protein sequence ID" value="KJH43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8XH47"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005863">
        <property type="term" value="C:striated muscle myosin thick filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12 13" id="KW-0009">Actin-binding</keyword>
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    <keyword evidence="11" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9 13" id="KW-0518">Myosin</keyword>
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    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
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        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
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        <location>
            <begin position="84"/>
            <end position="785"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1101"/>
            <end position="1142"/>
        </location>
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        <location>
            <begin position="1755"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJH43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1926" mass="222306" checksum="E709330F6AD43921" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHL2</accession>
    <name>A0A0D8XHL2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative UDP-galactose/UDP-N-acetylglucosamine transporter srf-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_09868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="KN716499">
        <property type="protein sequence ID" value="KJH44108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="315"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH44108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="351" mass="39652" checksum="6CFC810C2B0111A7" modified="2015-05-27" version="1">MPSDFSFKYGGLILLTLQQASMPLLTRYTRYRGESEIFFTTVNVFMMEIVKLCTCTAVIICSSNSVFRFFVELKEAICDNPIETVKVCIPAVIYTLQNNLYYIALTHLEATTFCVAYQMKIFSTALLMYFFLGKKLSVLQWIALVILVIGVVDVQLVYAPTASNEAIEQKPLLGFISVVVMCFTSAFAGVYLEKMLKSSATSVWMQNVRLALVGIPISIFSMFFYDWENIQKDGFFRGWDIFVVSLMVTNSVGGLLISIVIKYADNIMKAYAQSVAIIGAAIGSWLLFNFIPGFLFTIGTILVMISMVMYTTFPYEPPEFRYNRFSEKNTTLNATNSNEDHRKISGLTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHN2</accession>
    <name>A0A0D8XHN2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716497">
        <property type="protein sequence ID" value="KJH44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHN2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="32615" checksum="F1307BAB9690EDD7" modified="2015-05-27" version="1">METLWFSYEIVYSSFCKSNDFDLLCISIGMGICFLDSETIDFLEIFKILSIFQRLTRNEEWNHLFLNSYFLLDRRVVYHGKNKKKQGDGALIISETLLSDPVLTNGNKKLNVLLFHPLQSLEIICAAAINVGGGDINLVSDLIRYDCYFDSQNFCTSHVDYFGQCYTHAIGYESSLYFMLCTKTASRVTFGETHAMVTFSFILTSQFKEDELNQIRAYFYSIEEETKKLTRRSRYSLKKLISSIDYNFFLEVMEEKGKLTFSCKDWSYLLLAVDVTLPQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XIP8</accession>
    <name>A0A0D8XIP8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716467">
        <property type="protein sequence ID" value="KJH44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XIP8"/>
    <dbReference type="STRING" id="29172.A0A0D8XIP8"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
    <sequence length="629" mass="70264" checksum="76C9248387EC95B0" modified="2015-05-27" version="1"> </sequence>
</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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            <begin position="47"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13217" checksum="F4A421B151759F16" modified="2015-05-27" version="1">MAIKNSQPVEALPNSESTLRNSSEIQRCSNSQMASVASRIFDSSKQTPRDSSDLGKTRESFADRFSKGIHELTQGSSGRLLRWKTKLQNGGYCRRQKDQSEPPPTQRFFLLQNIPEI</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    <sequence length="144" mass="16948" checksum="FE2012F500FF9261" modified="2015-05-27" version="1">MKHAACAIWGTTVNRGNESHNHNQASLNSEISNRKLMYMLMIVVACFSLCWFPLETYLLLNEIRPEVNGWKYINVLFFCSHWLAMSNSCLNPIIYGLYNDKYNREYRRVFRILRCQTVPESFDEGLKFETEYSPGLMTDRMIQA</sequence>
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<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL36</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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            <dbReference type="ARBA" id="ARBA00006803"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="7">HannoverDv2000</strain>
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    </evidence>
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    </evidence>
    <sequence length="190" mass="22035" checksum="47455E45462D70B5" modified="2015-05-27" version="1">MSQLNGNLTMARGSVAATLSRAAVDWMVNTVDLSTLLDQLNLDRLGVDEVFIPSLQVSEDFDMPGRFTKECVQKGHILDSITRAEIWVYSTVPCLTRNYRHSVCVFGIEDLNRLSKNKRLSANKIRTEFDYSIVECVHELLFNRTYLEQIDNPLNMSYYANRQEILYHKNRLYRNESFKLDCNTNHSTWA</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="21352" checksum="E7420FE3D75ED628" modified="2015-05-27" version="1">MTAQISPAILYASIMVTWIFIERSDNIMVVCVITAPITGYIYKVYTKSVLLFSILIIICYIAFIFFIKKVHISNDNARNIYRSLIIVSLTVIFGWFSTMLIDIIADILHVELERTYINLLAGVFLNFASATNFFVYYTVSKEYRQMFDEYLFIGLLKKKIGLNVNVFTVGQHSRRTHQSCRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716496">
        <property type="protein sequence ID" value="KJH44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XP28"/>
    <dbReference type="STRING" id="29172.A0A0D8XP28"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
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    </dbReference>
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        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29633" checksum="8AFD8EE27294C925" modified="2015-05-27" version="1" fragment="single">FKSVISELEILCCTAVILRATSMLEITEQETSGKLSRSLIAIYASCSDESKSDVKKYTSEEIREHKITRFRKQKELKTVIDQLKNEQQMNKMDESVQRRLYLTVLKYWSNKVVEELESIEEELPLVEMMRNRLQTRDVEKDTSTNSLFFHDEKPTTLKPFILTRSAQQKSVFGLGYPSIPTMTVDEWYNQRFGDTFSQQKHGKTEYSKGDSGDEGSSEDEHEENDEQTRAQLMKWDEYKDYHRRGWGNTHNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPT4</accession>
    <name>A0A0D8XPT4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716386">
        <property type="protein sequence ID" value="KJH45794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XPT4"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327">
        <property type="entry name" value="SPERM MEIOSIS PDZ DOMAIN CONTAINING PROTEINS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="302" mass="33423" checksum="F5A3F41FEA7CCCC7" modified="2015-05-27" version="1">MRDEQLQIQECRGNGTDRTHSGIGGEESVSSCLLQTNSDMLPTPLSSNANFPSRGNVNVVKKRDGFIYTLVTIDNIEGQRLGLGIKHCQDQVIVSKSEKGSICASRLKVLDHIVDVNGTPVIDRDICRDMLIKFMQVDTKCCISKNESHDCHGMNTSRMILQDSNKVTLLVERPVSSKAIAIMKDLLENKRPPSLPPSLHAAVAPQDDRQNSSNSMQLKNPEDKLHMKNKGSANNLPAHANKVLPMKAVVDNKQIVAKKKNIAQNLTSPSVSKRKAKQFKERSGNLISVRFLLISLMQFGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPU9</accession>
    <name>A0A0D8XPU9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716476">
        <property type="protein sequence ID" value="KJH44401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XPU9"/>
    <dbReference type="OrthoDB" id="5868564at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="12408" checksum="DE98EB3EE0DB7C21" modified="2015-05-27" version="1">MEKNAMNMNKKKEEIDRQRKRTIPLKTSSKKQTKDLALYAALKAESNFVAGGTVLKLEVQVLRRLSGLPHVPQLIHSGKKEHYCYMVMTLLGDSLVALQRDKGPKKQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPV6</accession>
    <name>A0A0D8XPV6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_08143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716385">
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="328" mass="37216" checksum="7948F85B88125A12" modified="2015-05-27" version="1">MVVVRPFIEVLRRNNFQTEFVEEHDRLFNEAKCNGDHRAVTSHYYSMMSTVIEEYFGGNFHFAPPHKENLSLDEALMELHRKIGERLGLCEGMTCVDLGCGIGGVIKDLASTGANLMGITIAANEVKIGNEELRKLGIESTCRLVEGHCQRMPFEDESKDSAYAVYSLKYVPCLDGIMREVSRILKPDGRFLIYDLIKTEKYDEKNNTHIEIIEGLEYACGMPSLHTKAEMMASAERFNLVFEGEEDLEETNGRPFHYCFSHSSIFMWLVESPFIGSLISVAQKLRILPRGFQYFNRIFLSGTVEKIVNGGRLGILSGSKILVFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ13</accession>
    <name>A0A0D8XQ13_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_08125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29172.A0A0D8XQ13"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <ligand>
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        <location>
            <position position="120"/>
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        <ligand>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH45832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="18818" checksum="5F2D9844DF307633" modified="2015-05-27" version="1">MMNFFHYFAYGSNLLKERIQVQIKGAEYVNNGVLKDYELDFVAYSKRWHGGLATIKKMPGSEVHGCVWYVPEEFAEELDRQETGYHRLTVSIQCDNGLMECRTYQYSDSKALSLAPSPHYKTVIVAGAVEHSLPSSYIKTLVDMADNGYKGRVEVDIDVIKHLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQM4</accession>
    <name>A0A0D8XQM4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein, SNF2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_06975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716327">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XQM4"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="SNF2_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
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            <end position="255"/>
        </location>
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        <location>
            <begin position="563"/>
            <end position="728"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1246" mass="140613" checksum="6B396EA2FA455551" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQU5</accession>
    <name>A0A0D8XQU5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial basic amino acids transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Carnitine/acylcarnitine translocase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mitochondrial carnitine/acylcarnitine carrier protein CACL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ornithine transporter 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 25 member 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DICVIV_06857</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) = L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:72807"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72799"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:143006"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine(in) + L-arginine(out) = L-ornithine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:34991"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72803"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716322">
        <property type="protein sequence ID" value="KJH47048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQU5"/>
    <dbReference type="STRING" id="29172.A0A0D8XQU5"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000037">
        <property type="entry name" value="Solute carrier family 25 member 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF61">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 23" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="190"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJH47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="36769" checksum="0B5E0763357D65BA" modified="2015-05-27" version="1">MSALDFFAGCLGGAAGVLAGHPLDTVKVRLQMQHAGSKLYRGTWHCFKTIVHKEGISGLYKGISSPLASLTAINAIVFGVHGSVSRDFAQPDSIMAHFCAGSAAGMMQSVIATPSERLKLLMQIQTDEANKRYQSPLHAARSLVKNHGHRTLFRGFLATLCRDCPAFGIYFASYEWMSRHMSKDGQMESLTGPQLLLAGGGAGILSWLFNYPTDVVKTRFQAGKYENYLHCIQTTYLQGGLRAFYIGLGSTLLRAFPSNAATFFTVEWTYRLLLDFNVLDIGSSTEKRLQVDEEHSTTIAERLSRFMPAIYMKEVHASDNSYCTSSQSMLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRN5</accession>
    <name>A0A0D8XRN5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hexokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_07532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716354">
        <property type="protein sequence ID" value="KJH46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRN5"/>
    <dbReference type="STRING" id="29172.A0A0D8XRN5"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51990" checksum="393677DEF45F1DE3" modified="2015-05-27" version="1">MSIIYLNTLVTMFTTYTTPYFKTFKYMIITPVMLLRILIESQVRHQAAIDKRPGVQDSKKIVGTAEALLKKVITDVKNEFSEEVSRIGVSGQQHGIVMWNSLSIKKGILDCSELYNWMYPGDVAAASKLPKSSSNNVFPGYGMRTLCELATYPEFDQTHHWNRCGNIMDYFACYLTGSEEVIMSESNALAWGYSRNLKWNPEILPFIPKWIELPKIVRTDVREFVEIGRARLGSVTNVPVSVALPDLHASIMSVHKNCQGTNYAYLIIGTSCQLCFLVPDTAKLPALPITTHVFPFSKGIILVAAASMNGGNALDAFLSTIRRWSAEASKVESSPLDMSLLMAEVDEASSRLKAVPQDVPQVRPVFTSERGSVYTGAEIRGIQSNTSLIQMLIGVCQGVVRNIFDLVPSEMFVSLGIEKLFLVGIAKQQRFLVHIKKCLDEIGAGHITVESTITDTSAAYGVALYASMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS23</accession>
    <name>A0A0D8XS23_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cation/H+ exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="200" mass="22673" checksum="D017B4BB547B2D4A" modified="2015-05-27" version="1">MSLAISVGIQFFVIDSVHVIIQHVLLVLMHYRIFHAIPHLAEMFPDSALLIMIGLIIGIIFNLIGVAKNEFFLDSKVFMLYLLPPLVFDAALSLWAISLTGLFSVETPLVHLLLFGSVAADVDPVAVIVIFEELKVRKECFELTTKRHWHYIKCHAILLNSSIYLIILIRSISQQRNARNLKEISEQCILSVRGNVKRNL</sequence>
</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF03807"/>
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    </evidence>
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    </evidence>
    <sequence length="72" mass="8147" checksum="2A7011D3CBEE934A" modified="2015-05-27" version="1">MKIGFIGAGKMAQALARGLINSVRKMGQSIRSNFSSIVDERYFEHHNLIDNCNDSIWILDFIRLFSLSLISS</sequence>
</entry>
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    <accession>A0A0D8XTR0</accession>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361180"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47905.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="581" mass="67463" checksum="8F843D61314DC27E" modified="2015-05-27" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716318">
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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</entry>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
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    </dbReference>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="292" mass="32996" checksum="0A1A4FA39B998450" modified="2015-05-27" version="1">MSQKVKSAAERALSIVEKSSRVRIQDLRDNIGARTSGRQAGHTRGALQHAAKPPLGWIWGNFFQPWQRLFPGEKYFNADINTRREYIPLSLVELSRLIDLGWVNPKFPIDITTLFATRKFQVEALPMQYGFDLTPEGADDFTHKIDIEVQYASESSISAVEKAGGRIRVAYYDSTAFQAAMDPLKWFKAGNPVPARKAPPPSLLEYYTNASNRGYLAESHELVEARKRLALVMGYDLPNEEICLGQKEPNQVFHGIPPGAVVSLTDKKVFLPTHPVVKDYYQKHFVTDKQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUL0</accession>
    <name>A0A0D8XUL0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_06480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUL0"/>
    <dbReference type="STRING" id="29172.A0A0D8XUL0"/>
    <dbReference type="OrthoDB" id="5800741at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="157" mass="17978" checksum="D97DBCAF1DBC14B5" modified="2015-05-27" version="1">MFKPCSSREQNNTNVDDEIVSVYSKKSFIVPSKSQVLFYLSTSRHFRIHNTGCELQNVVYYAVHSRGLNQQSFTPAPTKWPDEIIPDKGERREKKHNIIVKHISRVAFCKVTDSADFPLFDIWAESTCCGRPVWVVESYVVSELRQTFVINSNCDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUX5</accession>
    <name>A0A0D8XUX5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716301">
        <property type="protein sequence ID" value="KJH47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XUX5"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002486">
        <property type="entry name" value="Col_cuticle_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF351">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01484">
        <property type="entry name" value="Col_cuticle_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Nematode cuticle collagen N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="301"/>
        </location>
    </feature>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="341" mass="34958" checksum="C44721021BC21ECC" modified="2015-05-27" version="1">MKKTGIDSYPLSSLTMANPREKMYRVATALQITFSIFSVCILCLALPLMYNNVQTTIDYIEQEMAFCERSNEEALMELEYGKMSYNRTRRSPSSTFPVKALGDDITGTPLETECPGCCIPGPPGPRGPSGTPGKPGTPGQAGKPGIPGTTPNQTCPMNLNREPPPCRPCPKGPPGIKGWPGFPGDVGPPGPPGEKGLDGEDGAPGEPGPPGPTGYKGGPGAPGEKGPTPEGELKEGPPGDDGIPGPMGASGMPGLPGRNGLTGPQGERGWPGIPGEPGEPGYPGPEGPMGGQGPPGEPGVCVCQNVDSILLINPGSQPRIQTDNYESNSAAVPSPGGYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV37</accession>
    <name>A0A0D8XV37_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxy-3-methylglutaryl-coenzyme A reductase</fullName>
            <ecNumber evidence="3">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KN716298">
        <property type="protein sequence ID" value="KJH47649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
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        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH47649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="468" mass="51050" checksum="B8069CF22F367C8C" modified="2015-05-27" version="1">MSRKDRDVRSFIDSLDVSKSTWKDDVERWILMKIESVRLERRTTHFNIGEECKDYNAIDLSSVSDASTQTAPDDDPQTDAKTASKSLDDISREWNEGKVISAYDALRLVKCGIVKCRELESRLNAETAIFVRRSYVAPGILKHLPYQNYDYKYVTNSCCENVIGYMPIPLGVAGPITINGREFYIPMATTEGALVASTNRGCSAIKHSGGVSAHVIDEKMTRAPVAKFPSASEALKLKTWIDVPENFARLKAEFESTSRFAQLRRIDVAIDGNLAFIRFVASTGDAMGMNMVSKGSSLAMNFLKQNFPTMRLLCLSGNYCVDKKAAAINWIEGRGRSVVADCTLPATVLLSILKTTAKQMAEAAEDPAQVVSSSMCSTRMEATPKGDLYVSCTMPCIEVGTVGGGTILRPQNECLQMLSCAGPSASVSGLHACRLAEIICSAVLAGELSLMAALVTDQLVSSHMKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV78</accession>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716264">
        <property type="protein sequence ID" value="KJH48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XV78"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="65" mass="7188" checksum="23808CA2FD56BD6E" modified="2015-05-27" version="1">MSVTELISRKQNNKQGLGITSVLSNPSEVKCSSPRNMTTIRRGTINDRQPLKPDKSEAKDKGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV87</accession>
    <name>A0A0D8XV87_DICVI</name>
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        <submittedName>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716297">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="370" mass="43134" checksum="8BB2AE281BD84598" modified="2015-05-27" version="1">MNHSDSEMEDLLCPAQLEDEKSKNLSKLPRRIHVAKHSKTSSSQKLSLNQKQAEAFRERAKKKKDAKRLAREEERNYVEFRKMEILYKFRPKSTATSRNPDDNLNAEIEGEFLKLCINIISGSTMIAESFPRRRRGVSMGFGERKAYFLSIRPNPKYATWFGKKKQQVIKDDKPRILLPFKPMPEKSVVPQLEDDDDIDENQKAIVERKGNNERNPFIKGCPFWTVSTGEEEEMAEDDYPVDVDAIEKIVNGAQLKEPPYVKRKFDVYEEIEYFKKDDVLFNRELIFAYTVTSVLNMFLNDATKRENPPSVKIRSESQITEIKLPVTWGNVITVTTFDVEKREPKLKRIPHEEPLKDNRLLPGETQKMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVI3</accession>
    <name>A0A0D8XVI3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DICVIV_05212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716260">
        <property type="protein sequence ID" value="KJH48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XVI3"/>
    <dbReference type="STRING" id="29172.A0A0D8XVI3"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="90" mass="10676" checksum="5F913C9710D52583" modified="2015-05-27" version="1">MYPLQSSSLQVYPIQLKTLLNHETNGTYFKDRIIRGMEGIKVSCLQWDSSPNHIKYRMDIDRDGLLFREVHVLFSRMGQLFKKEIIIIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVL6</accession>
    <name>A0A0D8XVL6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7087 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_07564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="DUF7087"/>
    </dbReference>
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        <property type="entry name" value="DUF3278 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG20338"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7087" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="148" mass="17604" checksum="3D4FAB4FBC675B2A" modified="2015-05-27" version="1">MCRFFDNYDFPYIVGMSRGIQFHCCIFQLLMIYSESGNISVFNFIYYNILCNMYTIHIFRRWYYNLDGRFDMHQLIREPENTVKIQYSIALFTPIVLSVLIFITVKLHTNFIRFLFTLTCIAEMSLALGILILEAFEIFVKETNSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWK5</accession>
    <name>A0A0D8XWK5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_04817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWK5"/>
    <dbReference type="STRING" id="29172.A0A0D8XWK5"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
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            <begin position="253"/>
            <end position="263"/>
        </location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="50924" checksum="60E591893F5DE407" modified="2015-05-27" version="1">MSQFIVPNEAFKIMEKDRDSEQSLFHVPPFKSEQTLDELVEEVGDLATRKVVASASILWVCLDAIRVACVVWVKDDSAILFQMSTTNDVQLVPCVIKKKPHLKQMNFESRRFSNKIATMSDVKHISFEVEQLLAREGLMQDRNAARDRLVISLGGKMPKGADMNYKVLKEELKRRKLEEREKAAEMKTVRERSTSRTLSRSRSRTRSRSPVRSFSPRDRRGRSRSRSPFRRARRLSRSPSRSRSGSRSPPRRDSRRSRSRSARGRRDTYLRSRRDSDDRGRGRGRLSRRDDPDPCRCLGCFNLSVYTTEKDLRELFGEFGEIEKVELVYDHPTGRSRGFGFVYFERLEDACAARDKLSGQEIDGHKIRVDYSLTKRAHTPTPGQYMGATRGSRRNYGYGSGGYKSERRESYRDGYAARSSRRRTPSPPRRERHRSRSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXH0</accession>
    <name>A0A0D8XXH0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716238">
        <property type="protein sequence ID" value="KJH49348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXH0"/>
    <dbReference type="STRING" id="29172.A0A0D8XXH0"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="246" mass="27157" checksum="95D8948531D00D83" modified="2015-05-27" version="1">MVALITNISSILTLTDILVYARRKAAKWSSIEIGALVSGNPLIVVSAETKLIEACQEFCFNGIYRIIVNEPHSGDILYLLTSRRVLQAIHKQNRSLYFAQWLSSSIKDSGVGTWGNTIHSVSLYDSLDDVVEKLLNYKLSSLPVLNSDGHATDVLTKTDFAMSVMEADDPQTFLRETAVVAVLGNRKPAVFVRPSDPVGKVLDVLLEAQHMRCVFVIDDCLKPIACVSQCDVISHLIYSDAPFQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXK6</accession>
    <name>A0A0D8XXK6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ERAP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716263">
        <property type="protein sequence ID" value="KJH48562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXK6"/>
    <dbReference type="STRING" id="29172.A0A0D8XXK6"/>
    <dbReference type="OrthoDB" id="5866590at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="135" mass="15619" checksum="5EDAC70A6069D9C8" modified="2015-05-27" version="1">MKPMYDRISTEYIAGHYKDDSLFSQIIAAPLRPLVYWYGVKEGGPVAFEKVLKFDKIQKVQVEKSNLLKALGCFNDAEKLKSLLLLSLDRAASVIRRQDISDVFRSVSKNPAGLKFMFNFLMEKLRDIMERFQIH</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716254">
        <property type="protein sequence ID" value="KJH48842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XYD3"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="201" mass="22676" checksum="86B0E4D4EAE29130" modified="2015-05-27" version="1">MMQIISHDLNEVWDDISEFLDQENFRISEFSGMAFSPLETPTFGTFTRTPRIYDEFVQEPPISLAMPPPPPPIIPNATFTNSLVYCRQSSPTITTCRQTSFPNPYNVSTCSLSNNRCSSLPTTSTVSNTTYYATLPIKEESPPSSPEIAYSQFTEATYSRSPLANSLPDLNMPNQRNRKASSVMYYHKSRIITYHDGLEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYG3</accession>
    <name>A0A0D8XYG3_DICVI</name>
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    <organism evidence="1 2">
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            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="72" mass="8503" checksum="58E4DA04DF6635B9" modified="2015-05-27" version="1">MAFEIDLIDLITLERACKKICFEAYCDQITAILLSSEDDRDEYNKYLSELGPLMFRDSQIPILRRRRSTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYS7</accession>
    <name>A0A0D8XYS7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOMON domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    <dbReference type="PANTHER" id="PTHR36516:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36516">
        <property type="entry name" value="PROTEIN CBG04168-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH47511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="247" mass="27506" checksum="05E7ECB8948D1AAA" modified="2015-05-27" version="1">MFNTKHLTNSTTPVVVLIVLLFYGPTPFVMLYLFAFCLMVVSVATQQCSFNDDDISARWQVSGDELTIEFVNKQIANNKWTGIGFGPSMENLEVVVVKIEDNKPSLVTGFTSGYGPPSLDSNANVVSSLLQFNSNQLTFRFTRPLNSNGARKHSLEECQKWNFVKEGEVENGEIGSHSASPSSISFISSSPLNSEGEVRKHKNKPTAVTVCPKQCRELFQNRDVLRNPVPQKAIYNNHQSSRFDGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ45</accession>
    <name>A0A0D8XZ45_DICVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716299">
        <property type="protein sequence ID" value="KJH47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ45"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="215" mass="22657" checksum="F4A441AB925C5934" modified="2015-05-27" version="1">MSKRGRRDGSPDEGNDTDRGTRRGRRGDSSKSTIPVARKKVPSVIGTSSGKKVASGGNPRRGKAVFEEGDTGTNSPSTSSSSESDDLDVSFHINKKPQKGKVPPTQRKKRPALRKPSVKSPGKVFPGNYGQRSPPKAAAVTASPLPGAFRDAASIVPHCDSPTTSVGTAATIPMRLGDSATRCSPGGGRTLQDVEADEEVWLISLMSHILKNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y137</accession>
    <name>A0A0D8Y137_DICVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">DICVIV_03416</name>
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    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y137"/>
    <dbReference type="STRING" id="29172.A0A0D8Y137"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH50405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="553" mass="62657" checksum="17195F5A9A697436" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y182</accession>
    <name>A0A0D8Y182_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y182"/>
    <dbReference type="STRING" id="29172.A0A0D8Y182"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="106"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="33325" checksum="8592C5B2E98C110A" modified="2015-05-27" version="1">MSSDEDIRSTISQKINQAKRPNRLHVGGTQHADTEAQDEDFAEVAKTSKVGFIARHLLHASSGDFAEAAKTSKVGFIARHLLHASSGEKDGALKDVLAQKLYCLTRKEYPSVLREVSRSLERTFGCKVVHRSCQSHIVLMEHIEENYPYDLMAQAKKGLLSAILMFIFACKSKRTNVISITETVLLNFLKALGLTYEVPDPIFGDIKKLISPMHTAEFIYQGYISFSKSSDRCETQVFTYDWGPRATLALLGSFCSIMKDPEVDKWSNQVETMKHLEEEKKQIMIESEKYMCDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1I8</accession>
    <name>A0A0D8Y1I8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_03828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716217">
        <property type="protein sequence ID" value="KJH50027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1I8"/>
    <dbReference type="OrthoDB" id="5872746at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336110" evidence="1">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH50027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="333" mass="37034" checksum="9E04A8B79A8D2AD8" modified="2015-05-27" version="1">MWAYKLLIVLKAAIGNAEISSSSDLNCDFSSSCRWRNATNLEDNGDWIINNQYAADGTTFIIPREASDGYFAYTSSLIARSVALLISDVVNCQLGGANIKYWYFKTGSESQLEVCTRQPPGSKEFNSFKCYTGSTTNFAQQWIFRVIELPPLSQPFELVFRSTFYPPMDIVALSDIVYTSTLCEISNKGAQQGAGGSFQTEDSTAKLLKFNEGKAGSFVYAGGKAVSRHDKFILSNKIPIEISEPARLDFFVYQAGVKGRLQVCINNIKDCVLDIRGDTINIKARRWRNFHVPLATNTHAIHFVADGLQDNYAIGLDHIQLLNKHGMAAQQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2J7</accession>
    <name>A0A0D8Y2J7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_03598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716211">
        <property type="protein sequence ID" value="KJH50234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2J7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2J7"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH50234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="144" mass="16233" checksum="ED4E102EAC797454" modified="2015-05-27" version="1">MLPSGDTFIAATQRPDGSWRKPRRVKDGYIPQEEQPKYQNPVQVATASRGRVVVGMTPRSMKQVTTGPRQPIAAIFKPNAAITPQEQIQKKIDKVKLKLAEIAKLEERINSGELIPLPNQLAKVGRKSEYENEIEKLTEEMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2N9</accession>
    <name>A0A0D8Y2N9_DICVI</name>
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        <submittedName>
            <fullName evidence="6">Vacuolar (H+)-ATPase G subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_02703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2N9"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13703" checksum="83584C0E0BFAC3FD" modified="2015-05-27" version="1">MSCSSLRGQAAYFNPIWEAEANGESKIIEATKRRIRRKREARYLAYAEIEQFREEKEEQFRKKCALLKEEEERQKERIRNNVDEEVAWMKARVKLCKPIVIIFYYLLLYFCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2Q2</accession>
    <name>A0A0D8Y2Q2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716205">
        <property type="protein sequence ID" value="KJH50447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2Q2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="278" mass="32603" checksum="C196AB31889C3550" modified="2015-05-27" version="1">MWFPATRRNPVEVSDEESHERLFYMKKNKDFNDLNSLCPMRKLLKLNREFFYLLQYSHDSEALFLEQCMVRYIHGAVQVQLLKLNREFFYLLQYSHDSEALFLEQCMVRYIHGAVQVQRIKLCGNRKSLQAYWKSIQTEYQLKCSARVDPDNRTDKALRGILKTSTLSKGQSHTRSTMSINAKHRNKFRLPIEEENQREKLQNNADGGVESGLRAVVTNGVSIEELLNQYKANEIKTFLNVLNELAWAGLEALEELWSRTIEASAYNRIATDLFYQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3S8</accession>
    <name>A0A0D8Y3S8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716196">
        <property type="protein sequence ID" value="KJH50832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y3S8"/>
    <dbReference type="OrthoDB" id="5860929at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Crystal structure of tRNA isopentenylpyrophosphate transferase (bh2366) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21624" checksum="B6AEF9954F41A63B" modified="2015-05-27" version="1">MYEWNCFSSTSKQYRNKSTTFQNKENLINREHFGVLQCIGLKEFIPYLELSLSDRSSSIGDKFFEKGCDDVKLHTRQYARRQRNWVKSRLFQRQEIREVPSLKKIDTSDKETFISVGLGVVDQWMNGSDFKEETTGNVENSEDANMIRHCIVCDIIVQGTRNWNKHLIGKRHKKAMRIFGMSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3T8</accession>
    <name>A0A0D8Y3T8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3T8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3T8"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053014">
        <property type="entry name" value="Cuticle_assoc_divergent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y542"/>
    <dbReference type="STRING" id="29172.A0A0D8Y542"/>
    <dbReference type="OrthoDB" id="5832574at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="460" mass="51889" checksum="69A12BBAC8825B2A" modified="2015-05-27" version="1">MAGDADEEMIESSGEDLEIDMNSQSLKICRCGAYDKIMSATNLLRKRILEAVNNELDQYEQPLGCLLGSSKQIFADCHKEYGPVENDRVILDSSLSEVAQHTSVCRRLIEKFSALSEDSFECKEWVYILNCFSKNVKLPSEFVSQCLTNSKVFMFNAETFADDSVDSERAESLILHSNREVLLSTGMVNRVLNLLFPPDRLTYNLDQLLCDKDLTVEAVVIENAADVISILKTDWISLSLFCGHLAVPFTAAALAYVHCASSRPANVTPPLSFQLLESTISSFATCLSAEALFMEHVFTSFAKLLQKDSELTYFMEILFGLEVVSVWIDFSAAKCHELSSSFWNAISKALSFIEREAEYLKQESESGTEAVAIASPEEITHDETIDENWLERIIKQVPTMIDQQSVLRTLHMSIILVVLTLSEEKIVKILVYKVIIMSIFCEYRKTVIVEWNNSNQQFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y559</accession>
    <name>A0A0D8Y559_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Renin receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y559"/>
    <dbReference type="STRING" id="29172.A0A0D8Y559"/>
    <dbReference type="OrthoDB" id="7866065at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056780">
        <property type="entry name" value="Renin_r_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012493">
        <property type="entry name" value="Renin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13351:SF1">
        <property type="entry name" value="RENIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07850">
        <property type="entry name" value="Renin_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336348" evidence="2">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Renin receptor-like C-terminal transmembrane spanning segment" evidence="3">
        <location>
            <begin position="251"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="36436" checksum="8236727682F5CD48" modified="2015-05-27" version="1">MRRAFFPLVIITIVLASELHFVSLPHSVKLTSAQADRRLTTSELNDLNNLLLGLSTKPVNGIEVEADLFLRPRAIVIITVNGVRSLNITNPDMIYKLDYDGIDHSFWNIELASVFGPDHEFVSVTREGINGSTIANATIHQANYKFNTNLKMLGEELQHIHNLLDSISTHGAKFSDSKGPVVYLVSITGLASHGLSDLERDVAISDIVGVINKFPEVLSATYDGRVIFEVANVFDLNWPHPSEEQFLKRRKRDTDASPTDSNLKLWREKLNVYVFVGTDYPAIFAIFAGLTIALVLAVLYAVVAMMSMDPSKDSIIYRMTTTRMKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y579</accession>
    <name>A0A0D8Y579_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_01729</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y579"/>
    <dbReference type="STRING" id="29172.A0A0D8Y579"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003546">
        <property type="entry name" value="Tyr_Pase_SptP/YopH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01371">
        <property type="entry name" value="BACYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="103"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="275"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="392" mass="45252" checksum="F127CDCD37DEDFEB" modified="2015-05-27" version="1">MIMAERAADCLAKLGLDGSGHNMSLSEQPAHLQPTFGYHRRCRSLRERTGVDHRLERLPSGPIHKTPLYTVITGVNTNKSRPVEISDFTDHVHMMSVDSSFRFSEEYEILRNVGCGQTYNAAELPSNKSKNRFTNILPYDHSRGFSSRREFIAAQGPLPTTRDAFWQMVWEQGCPAIIALTKCVEKGRDKCHQYWPDVEHSTVIYGDIEVTMLNESPSDDFTVRELRLRRLHDQTQTIIIQQFHYMTWPDFGVPEHPQGIIKYSKEKTNNHIYFFRFALMFRSRLPHSAQNKPTVVHCSAGVGRSGTFIAIDRLLQTLQIGRPIDVFGIVYEMRLERCHMVQNEQQYIFIHHCILYAIETMISKGSLSRSKMDELHENPVFKDDETIVESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y693</accession>
    <name>A0A0D8Y693_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycolate/pyridoxal phosphate phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_02256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
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        <property type="protein sequence ID" value="KJH51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y693"/>
    <dbReference type="STRING" id="29172.A0A0D8Y693"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PhosphoGlycolate Phosphatase Homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF83">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="254"/>
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        <ligand>
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        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="338" mass="37394" checksum="8EF74E62FBD0B42D" modified="2015-05-27" version="1">MTKPHCATVCNNLIDSHVRELKRECISRELISHLFPGSFRRLLCEIDTFIFDGDGVLWLGDNVIPGSLLLIDFLIKNNKQVIILTNNATKSCALHAKKLSELGFNSKMNEDTIVSPAVVVADMLYEAGIIGDRKVYLIGSQGVRDEMDKVGVNYFGHGPDPQDNSDDSAFVFDIDYEVDPSEVGAVVVGYEKHFNYHKLMMVTNYLQQPDCLFVATNEDEACPGPNPHIITPDAGPLVAAVKCASGREPITVGKPNKPAFDYIKKHWDIIPERTMMIGDRLDTDIKFGRDHGMKTLLVLSGCHKLQDVLTNHANGDLDMVPGYYASSLGALLETRDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Q5</accession>
    <name>A0A0D8Y6Q5_DICVI</name>
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        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_01382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KN716165">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="134"/>
            <end position="311"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH52405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="661" mass="74352" checksum="CD7D279B72639035" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6Q7</accession>
    <name>A0A0D8Y6Q7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716211">
        <property type="protein sequence ID" value="KJH50251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6Q7"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
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        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8791" checksum="80D9679C0D373842" modified="2015-05-27" version="1">MTVEEAEVGPFQLRFRLVRIGRINFSHDSAVRLMFREWTLLDEERFESRLLMATTVTRRLMEHTSVIYTKIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6R4</accession>
    <name>A0A0D8Y6R4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_01961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6R4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y6R4"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF111">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="136"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Copine C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH51882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="475" mass="53447" checksum="87B2654DB72E0716" modified="2015-05-27" version="1">MRNISPSQAASGIKASIQKFLEDERTYIEIGQTETVYDQTNITYKHRCPLDYRFDRLDRLKVSVFYAGVGTLTHCIGEVFTDLPTLIGKGGTLSLPLSPSAAVDLYIITPDFYSHYVKLQFSGNHLQMRESLPLAAYMILILKTDKKEFLLYRSEVIKDKNPRWKEFSVPLSIIQFYDQGFLQIHCYNYNVNKNDTLIGFCSTSMAQLERGVGPLNSYMLMNFDGKRINERMNVNLESMELVHGESFFSALKNGTHLHLTTAVDLTASNGNPNQSNSLHYIHPHTNSPYVIAMTKLTPLFLSYMAHTKLGALGFGARIEPRFELSQCFYLSGSHSDSQVDGLAGLLDAYRRARMVVQPFAPTDFSEVIYHVSKFAKAETRRHLGLYFVLVILTDGGLTNPRRTIDAIVDCSSHPMSIIAVGIGKDRDFANVKALESPVIKHSDGRPLCRQNFQFIPSEDFDTDDAVALIPVQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7M2</accession>
    <name>A0A0D8Y7M2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716172">
        <property type="protein sequence ID" value="KJH51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7M2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12776" checksum="02C61AD5E56414E3" modified="2015-05-27" version="1">MIPIHRPSDQRMYDVVCQEEETSRNPILRNNRTSVQPSMYIGHGDTSLRRYIYQLNRYSLSSIKISRIAQRRFRTVLLYEFTLPPNIRSYYNSSRKLASQYLSNLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8U2</accession>
    <name>A0A0D8Y8U2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dual specificity phosphatase, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_00648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8U2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8U2"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="659"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="727"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="823" mass="93652" checksum="C465658BD1CAA24A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y973</accession>
    <name>A0A0D8Y973_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716160">
        <property type="protein sequence ID" value="KJH52737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y973"/>
    <dbReference type="STRING" id="29172.A0A0D8Y973"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:isoprenoid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
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        <property type="entry name" value="Polyprenyl_synt_CS"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="474" mass="53886" checksum="B2D701016F9A031E" modified="2015-05-27" version="1">MTTPEQIKQVLDGVVEVRLVYRGRSKLTKGYGFVDLDSEKSYQEALAKDRIPIDGRPMLVSINNPEKRPVFKYSTGMEKSKLFVRNVHHNCTEDQLRDAFSMFGEVKAVRIVTHISGKPKGMAYVEFTKEEDALKAVEAPEIIIHDRKLIVAISNPPQKSAKADSSKSSIDPASLVSTDRKTSLSMVPRGVRTSSKMTANGIRGKLAMAFNIWLQVTDDKLSLIMEIVQMLHDASLLIDDIEDSSVLRRGLPVTHHIYGIPRTINTANYVYFIALEKCTLLSDKAAAIFAEQMLELHRGQGKELFWRDTFTCPTEAEYEEMVVQKTGGLFFLAVKLIELFSARTYDFSNLLRQISIYFQIRDDYLNLMSEDIAKQKSFAEDLTEGKFSFPIIHAIRCSPNSLNDDPVLKILRQRTDDIEVKKDCINLLNERHSFEYTLSRLRTISSQIRKEILRLGGNHELDEVMNLLEKGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y974</accession>
    <name>A0A0D8Y974_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol 1,4,5-trisphosphate/ryanodine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_00326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y974"/>
    <dbReference type="STRING" id="29172.A0A0D8Y974"/>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Inositol 1,4,5-trisphosphate/ryanodine receptor" evidence="3">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,4,5-trisphosphate/ryanodine receptor" evidence="3">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="2">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH53388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="232" mass="25925" checksum="0ECCC8744011A394" modified="2015-05-27" version="1">MIFFILSEKESKIGYGLLPWATGDIVCLSCIASHNRDGVLGSERVCLCTEGFGNRMCTLENVSDKDIPPDIATCMLYIDNALSMRALQEMMSADSERKSASGAGGHKTLLYGHAVQLKHVQSEMNLILGEACWWTIHPASKQRSEGEKVRVGDDVILVSVATERYLHMTFSKGYMVIASFHQTLWNIQSVSSGSVRTRNMGYVFGNDVMRFFHGNDECLTIPENWSEHPQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y990</accession>
    <name>A0A0D8Y990_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 12">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 12"/>
    <dbReference type="EMBL" id="KN716152">
        <property type="protein sequence ID" value="KJH53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y990"/>
    <dbReference type="STRING" id="29172.A0A0D8Y990"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Glutamate--cysteine ligase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="655" mass="75192" checksum="6754D9CF2C335850" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9M1</accession>
    <name>A0A0D8Y9M1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab proteins geranylgeranyltransferase component A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_00943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716158">
        <property type="protein sequence ID" value="KJH52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y9M1"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001738">
        <property type="entry name" value="Rab_escort"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016550">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="543" mass="61608" checksum="7F242EB062D7A574" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YD02</accession>
    <name>A0A0D8YD02_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_01311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716164">
        <property type="protein sequence ID" value="KJH52466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YD02"/>
    <dbReference type="STRING" id="29172.A0A0D8YD02"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH52466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="100" mass="11637" checksum="3F2D918904D1DBFA" modified="2015-05-27" version="1">MVVRVQHCRKTMEFFINFRDGSKARLKYSELPGRVLDFEHTETPPDQQGKGIAKLLLKEGFKYAADNNFKVKPTCWYAAKYVKEIATEDERKLLTTYSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEM6</accession>
    <name>A0A0D8YEM6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Furin-like cysteine rich region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
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            </authorList>
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            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="194"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="251" mass="27706" checksum="D3750BE40629CF63" modified="2015-05-27" version="1">MSFPYFLPLSCTDDCEVENESKCRRVSHSRGEQLSCWNKNTCQEDCPFDRINGSAGPGCADSNGAKCHDQCVAGCTVPNDDKACYGCLHYNHDGACIESCPPNLFVYLNRRCITEAECDAGVGLILELYYGNEDLICRMSTLRGGKEVYKPANGICSTICPDGLEEDPSNKKRCRKCAGECVRKCPGNITIESMSKAMQLKHCSVIEGYLEIEMRVGMSTVAASQLTEVFGKITTIDGYGFLKYFFISIMM</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="450" mass="49448" checksum="14FEAF9682C19230" modified="2015-05-27" version="1">MQPAGQIVDPNQYYYAAVPAQPPPHQQNVSFQYTGGYFTDPYVVASVPSQSSQSVIMPVGHPGIIYLPPPSTPVYYSVPTAPAAPTGAASYYYTPDVYVQQTMSVPQQFVQPHAVISSEASMNKMKSAVRPLSTSTPLPTEVASIPPPMTNQIPYNGNINVTHLKYHRNAEHDDVLANLSKISVVSEETIEAENEKDCEHRPVRQRRPPPVPFNYKTRMCLTYASGKQCEMGNRCKFAHGPEELRVADAAPRALNARYKTKLCKNFGPYASNYCPYGLRCEFIHPNDKEYALVCSTTSQQTRNLHTVGNISQNMCNITPETECEPPPISVTRSAIKPAAEKILLKNRNIAGSMMCLATTGRREQISDDSAIGSGSSESGVSCAQVKALTRARGSVPATVVPIKFLRRRSMSQLTLKRFNSIENLDIAASCSQLACLEQNRRALSIFSPLK</sequence>
</entry>
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    <accession>A0A0D8X5R1</accession>
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        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="159" mass="17706" checksum="05328518599F8D6F" modified="2015-05-27" version="1">MKMTNIVVNKRSFFMTIKQIDQGAYTCEAINVKGRVLATPDCIVRIVNIPAPVPPTRPPALTRCDPRGSVYPQADRAGTCTCKRIVQFENLDNVFSITQRDNDLFNTIFKPLVTGPACTDCYPGSFHLNEKSPQGCLKCFCFGITDNCRSSNLYRTQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <strain evidence="7">HannoverDv2000</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH39647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15540" checksum="4BB678C38335A0A5" modified="2015-05-27" version="1" fragment="single">IAACTGAWFAVISQLCGTSSDHWSLIAVSLIVSAALDPAWKINHLYSAELFPTVVRNMARAVCNSGARLGSIAAPMVVHLRSVHYLIPYLTFTLFLSAQVITVAFFMPETKNRPLPEMLPQPETLRQEEQLIEMNSKVINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7A9</accession>
    <name>A0A0D8X7A9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_13614</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KN717219">
        <property type="protein sequence ID" value="KJH40430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7A9"/>
    <dbReference type="STRING" id="29172.A0A0D8X7A9"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21775">
        <property type="entry name" value="MobB_NDR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05599">
        <property type="entry name" value="STKc_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="84"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH40430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="492" mass="57388" checksum="3EC9277380C3A835" modified="2015-05-27" version="1">MTEKLAVSQFMRDKASRTRLAIESYYAQIVTQSVERDSRAKKLEEKMIAEGISEDEKEKRRKIQHAKETDFLRLKRTRLEVTDFESLKVIGRGAFGEFYFKAESSESDTLNVYACKVRLVQKIDSGHIYAMKILRKSEMLEKEQTAHVRAERDILSEADCEWVVKMYYSFQDFVNLYLVMEFLPGGDMMTLLIKKDTLSEEAAQFYIAEAALAIQFIHNLDFIHRDIKPDNLLLDARGHVKLSDFGLCTGLKKIHRTEHYRNWPSQLPPDFVSKPIESKRKAETWKKNRRAYAYSTVGTPDYIAPEVFQPHGYTKSCDWWSLGVILYEMLIGYPPFCSETPQETYRKVMNWQQTLVFPPEMPISVEAKTTIRRFCCEAERRMGHNGGLEEIKQCIFFKRIDWNHIRERPAPIRVEVKSIDDTSNFDDFPDVDLRWPALSVPEKPENQPGHRGEFVDFTYKRFDGHTQKMRYNEMQKHSRGFGVSGEGAQTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7K4</accession>
    <name>A0A0D8X7K4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NNMT/PNMT/TEMT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_14355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KN720852">
        <property type="protein sequence ID" value="KJH39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7K4"/>
    <dbReference type="STRING" id="29172.A0A0D8X7K4"/>
    <dbReference type="OrthoDB" id="10050085at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF38">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="112" mass="12650" checksum="E277B04C44AA998A" modified="2015-05-27" version="1" fragment="single">MHINIMFPRTINIVSGPTVYSALCFRDTVKKIFLSDYLLKNLDALKQWCNETTSHDWKPTIRVIKRTEGGLPVTMKEVEEIEAKARIAVKCGGIMYANVHEDPVVSDLAGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X801</accession>
    <name>A0A0D8X801_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_13369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN717054">
        <property type="protein sequence ID" value="KJH40673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X801"/>
    <dbReference type="STRING" id="29172.A0A0D8X801"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH40673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="401" mass="45531" checksum="8D5A8502F22B095B" modified="2015-05-27" version="1">MSNPAKMSLQSLSTFRSDEVMDFAPMDHDERSKPFDFDVTHRDLIHQVAIRESSFVPVAFDHHGRRLATCSSDMTLSVWDRTADGSWKKAASWKVHGGAVWRVVWAHPEFGQLLATCSYDRSVHIWEEIRSDPSGGSKGGRWVRKAYLTDSRANVTDIKFAPRHLGLILATVSAQGIVRVYEAADVMDLSRWSLCHELQAFYTRCGCVEWSRSRIHRPLLAVSSDDKRAESDERIVIYEHNETLRKWQRVISLRLDLSYPVTDLQFSPIALATSHQLAVAAGDVHVYNIQIPVSAFIDDENCNTGNIPTDAVEYSSKKVAVLGDQRHAWRIKYNVTGTVLTASSTDGTIRVWKAMFLNQWALLTEMSAEDYLEERELMRMKGVLCETGRGDGEAFHRKTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X867</accession>
    <name>A0A0D8X867_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717033">
        <property type="protein sequence ID" value="KJH40733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X867"/>
    <dbReference type="STRING" id="29172.A0A0D8X867"/>
    <dbReference type="OrthoDB" id="6700855at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16423" checksum="F155D1649DB71494" modified="2015-05-27" version="1" fragment="single">MQEEIFQIKFPNALAKALFGNELLPSVTSSKPFLNWQSNPYSVYTVMMIDPDAPSRKNPKNRDFLHWLVVNIPGNDVNRGKEVVSYFGPKPPFGTGLHRYYLLAYKQSSKTIRLAEINSRAKLSMRTEAKMQSHINTNQYKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8B9</accession>
    <name>A0A0D8X8B9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717008">
        <property type="protein sequence ID" value="KJH40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8B9"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF297">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24138" checksum="AB89FEEBD754DBAE" modified="2015-05-27" version="1">MKRDIRKYFTTRERLHTDDFITFWLAFNQQLICEVEHFYAKHQTPQPRKAVLQRNQNISMEDMDGLSLASVSYSILLLMVFLLVLVKTILIGGIICCIGAVASYFCHSIVSFTLCFGGFIGVGLSLVYNAAIVIVTYNFELRRGVATALAVSGTGVGTIVFPLFLKFFVPENGTDIGPAIMAISIVLSVIIIIGLIVRDVEWQSDSPEYKVCILTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8P6</accession>
    <name>A0A0D8X8P6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_14078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KN718538">
        <property type="protein sequence ID" value="KJH40009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8P6"/>
    <dbReference type="STRING" id="29172.A0A0D8X8P6"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH40009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="372" mass="40920" checksum="6316F6D61395ECD0" modified="2015-05-27" version="1" fragment="single">DGKYFLGKSLGKKGKCIGEVSFTTGITGYQHTITDPSFPYQIITFTFPHIGNIGINSKDNEGGKEIFASGVIIRELSFVSHPLSCISLNDWLEKNNVVGISGVDTRALTRHLQKHRFQSGIICSLTFSPVYDAGIYDDQITFVIENLLDELKKYGTLNGVGIINKVSLSNSFKNDLNAKHEVVVVDFGVKASIVSRLIELGCAIELIKPDKGFAQKILSMGPDGKVLTNGPGDPQEIGESMILEIDIIIKSKIAVFGIYIGHQLLAITLGAKTFKMNVGHRSSNHPVNRVNDGKVEITSQNHGFVVDSSSLLSDVEVTHISLFDNSIEGIMMKNYPIFSVQYHPEEAPGTHDSHYLFKHFINDIELHKMKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X8Y5</accession>
    <name>A0A0D8X8Y5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717903">
        <property type="protein sequence ID" value="KJH40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X8Y5"/>
    <dbReference type="OrthoDB" id="5876828at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14423" checksum="DCFB4CF37430F5CC" modified="2015-05-27" version="1" fragment="single">MSYWIFIAFGTLRSRTAKGEIPTIEHKPLPKAANMYKMDYSCSLELDADNLVNKCLTDQKSPTFKDNGWNFRDINANTVNTQIEALREAILIWARTIIVDSLPQTVAPGRKDELAMPFLQSATAESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X973</accession>
    <name>A0A0D8X973_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716893">
        <property type="protein sequence ID" value="KJH41145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X973"/>
    <dbReference type="STRING" id="29172.A0A0D8X973"/>
    <dbReference type="OrthoDB" id="5873478at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="505" mass="55518" checksum="0D53892324362350" modified="2015-05-27" version="1">MTTQNSYKLIISYNLYERHATEGILVQPVYSLSINSFWVKLLMEVSPFLEKLLQDLDLKSTTVPTTTTTMTIPTISIESTTISENLLANKTSITIGSTSSMDTTTTNEITTTNTDGAFVNDVQAASSEKNLEIEIESAAQHSSTTTTESSNSSTTTTKTENTQYLLPEARLAKVITPIAGIIDDISPIIGPLLRSQVAVAKVHFLHIDNCFELFYNDINLMEHSDSENSIIGYGTQLAREILNPGSLKRDREIQSRPTHQVLQPKPFAESQVAQPRITYPQAFTRVASVPLAEQAARAARNFRTQSKVRQFELNQSIASKYFALPPPGYKEHPSTLPPLPPSSIPRHKSLSSLPYYPMESHKETLPVINSDSFSIIDSSVQSTTNTPLYTKTPQVSLVANEFIKQIPYSPPFKAKVKVAKQANRDSTGYQKGRSEVKSSFYEDSGVIMGDVEAPSQNLDGSSYTFKPSSGFGGGGFGGGRQPMVSFDESALSGNEQFSFFRTDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X9U8</accession>
    <name>A0A0D8X9U8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_12689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KN716848">
        <property type="protein sequence ID" value="KJH41338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X9U8"/>
    <dbReference type="STRING" id="29172.A0A0D8X9U8"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH41338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="374" mass="41951" checksum="DF1523277E5ACC43" modified="2015-05-27" version="1">MNTLLIPNARVAISSFRLVASNIQTPQLNERLSPKLTGDPHKSFYHQDLIVTPATGNELHRKPGLSETLKFGHFYADHMAFADWDEANGWSHPRITPLRNLSIHPGSKVLHYASELFEGMKAYRGVDNKIRLFRPEKNMARMRRTARRAALPDFDAEELIKIICVQITLDQEWVPYSSTSSLYIRPTLIGTDPTLGVGFPLNAKLFVITGPVGQYYSTGFHPIRLLADPQYVRAFPGGVGAFKMGCNYAPTIAVGKEAEARNCQQVLWLYGEEEEVTEVGTMNIFVLWKNEDGEMELITPPLERGLILPGVTRDSLLELAREWEDFKVSEKSFTLSDVKKALDEGRLLEMFGAGTACIVSPIGQILYNNRKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA16</accession>
    <name>A0A0D8XA16_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717085">
        <property type="protein sequence ID" value="KJH40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA16"/>
    <dbReference type="OrthoDB" id="5829537at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="297" mass="33346" checksum="126A2E5B1EDCFD60" modified="2015-05-27" version="1">MTSSKISSFLSRTSTNDTNRKRKAAILIVRFFNKLLSTAPTPFHRVFIGFEIMLSKFSEDHIEVLITSQSAFSEGAGILADELKQWRSLSSAVLPLYAIERNHLFRLSEPENDSTSERTLDCRPSLTKHPIDITNLTRNIEIYPYKKQNEMGSGGGCSAPSRYPDIAQNSANVSSPNRRSLIFSNSVEKDHPEISKASQLTDSCYTTETTTPNGMRRAKSESAMIELERLGDMTVLKIYDDVWGDIQFLSNNIIVLHNKQGPSQSLANLIDQKIKLAETKDNLQILLQMLSRNQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB83</accession>
    <name>A0A0D8XB83_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_14388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN721222">
        <property type="protein sequence ID" value="KJH39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB83"/>
    <dbReference type="STRING" id="29172.A0A0D8XB83"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="165" mass="18390" checksum="5E7B88CEADD10BF6" modified="2015-05-27" version="1" fragment="single">MTPTDIIVQMRKDFVEMLASKKWQDRKEALDNMLSIVECSPRIATSPELQNIMAMLLKVLDKDINVNVASTCAKVLSQLAVSMRTDFGEIVPKIMPIVFDKLKDKKAVIRNELVRLCDAAATTAPIECYGDAVCDGLNKSNPQSRSQTAYFVSRLLSRHNTSTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB86</accession>
    <name>A0A0D8XB86_DICVI</name>
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        <recommendedName>
            <fullName evidence="6">Phospholipase</fullName>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="EMBL" id="KN716744">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phospholipase D activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1131"/>
        </location>
    </feature>
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            <end position="26"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
    </feature>
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            <end position="700"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1295" mass="147199" checksum="35CCA9E143C2AE06" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBI1</accession>
    <name>A0A0D8XBI1_DICVI</name>
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        <recommendedName>
            <fullName evidence="4">Transthyretin-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335648" description="Transthyretin-like family protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14434" checksum="9395638E2770BB44" modified="2015-05-27" version="1">MSTIIRCLPLIFCLIVLTDGYVCKIAVRVSSNTDKKFKAVVIVPALGIQSQPMVFEKKGTKKMQVNGKDCGKKPWIIRTYEWADNKWKPAQNNTAKYQGNGWIKMTVGDDLKPTPMERFGVGCFEGNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC09</accession>
    <name>A0A0D8XC09_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716860">
        <property type="protein sequence ID" value="KJH41282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC09"/>
    <dbReference type="STRING" id="29172.A0A0D8XC09"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="198" mass="22164" checksum="40C1FE321980C068" modified="2015-05-27" version="1">MLANSVQVTHSDVVELSQRVLAFDTLAQIAYEAEAKRNLQTLIENNGISRAMKALAAAVSCGPVEIRARHLDAMATIFEKGEDEVLKEWFLYMGTPMPTVLLSLVQKPFPDLRMASLRTFATLLSHPFGIKVFLETSGFLDWLLDRTSEQEWEASKLKMDIIRSMIASESPLIDAALKLRLKAYFVTPSKDSTVEVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC18</accession>
    <name>A0A0D8XC18_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_14071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718506">
        <property type="protein sequence ID" value="KJH40016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC18"/>
    <dbReference type="OrthoDB" id="8299692at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH40016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15458" checksum="E0057BFB387B9DD2" modified="2015-05-27" version="1">MLFTGAFASVIYGSCKMINFFTAAFMVTMMAYKDEVFESTYPYLGNENSNVIAVGFFDYCCGYCKAIKDDVKQLINDGKVKYIFRDTPVLGNDSLKAARSALAVYFIDKGRYFDFYYAVLDYKGELSNENILGIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCH6</accession>
    <name>A0A0D8XCH6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716682">
        <property type="protein sequence ID" value="KJH42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCH6"/>
    <dbReference type="STRING" id="29172.A0A0D8XCH6"/>
    <dbReference type="OrthoDB" id="5813613at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="75" mass="8906" checksum="A5F9EA19878B9CA9" modified="2015-05-27" version="1">MSISGLVELNPNYFERELDYLQNIQQQPELKSEDSPMQKRAQTFVRFGKRAQTFVRFGKRAQTFVRFGRSTPKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCL5</accession>
    <name>A0A0D8XCL5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716808">
        <property type="protein sequence ID" value="KJH41517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XCL5"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="92" mass="10471" checksum="673FBC9F73B87C12" modified="2015-05-27" version="1">MNPCKNGALCMVTSGRNYQCKCATGYYGKNCEHKIDACYGHPCLNNAVCKIPPYGLKFLENFHTCKRDRIVFIKKGQLELKKELELEHANNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCM0</accession>
    <name>A0A0D8XCM0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intermediate filament tail domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716831">
        <property type="protein sequence ID" value="KJH41404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCM0"/>
    <dbReference type="STRING" id="29172.A0A0D8XCM0"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="41"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="7">
        <location>
            <begin position="446"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="577"/>
        </location>
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            <begin position="66"/>
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            <end position="29"/>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="577" mass="66265" checksum="2C2CEDEFA71EC595" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDG7</accession>
    <name>A0A0D8XDG7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_12344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="183" mass="20291" checksum="08FF28E14072819F" modified="2015-05-27" version="1">MMLTENGSEGAEVVLVTGASGYVALHCVEQLLAVGYTVRGTVRDKSCQKKVNYFQLFFNITFFDLLRVKMIPLQRLADENRNGRLELVEADIENPLDWPRVMKGCSFVLHVASPWPVVADSKTIRTAVEGTLNILRTASTISSIKKVVITSSCAAINGISSVFHTISLKINLHIYIHLLRVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDN5</accession>
    <name>A0A0D8XDN5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716632">
        <property type="protein sequence ID" value="KJH42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5876224at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="465" mass="52915" checksum="F30E71BEAABAE636" modified="2015-05-27" version="1">MVFTENTVTYKRGSKDTVLTNLTRLLSRLSGAMAPAAASPHSADAASTTVAPQNHNLDEVSFILSVTIYGGQRTMADVTMAICTSPRDRRIDTPQWTSDSGQNLYASVDSLEDGGPQNIYAPQSYRAKDAEKYELILKKKKKNHDLEEILPGFLPQNQFVPVSYAPSPYAQLMEQSRFCAKCGRDAVQDVIGAADHQPREQKNPFSQTERRNPFQHNPFQKGHEDKRRVPYASSRGDMWKEGDEGYGGKIRKEDDQPDAQEKNVHRCAEKIPNTLEMTKMKHFFSVLGSIDGECAWKPGRGSVRNPFSSPPNHSPNQFKGREPRDSGGLWNSKPTEKFYKFSCRMLRQCAWKPGRGSVRNPFSSPPNHSPNQFKGREPRDSEQREKFRKPAPQCPQWEDRHHRVNNNCPLWHPYKMCLFYPNCRSTALDCGYAHPFCSEDECECAEENKDPQLNHWIGPNRTYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDQ7</accession>
    <name>A0A0D8XDQ7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716632">
        <property type="protein sequence ID" value="KJH42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDQ7"/>
    <dbReference type="OrthoDB" id="5802469at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19563" checksum="49E621C63973FFFF" modified="2015-05-27" version="1">MFEQHQKDITDYAEHFQIVVKLSAEFDKFYFCCDVRATPKDITDYAEHFQHGEIAHMSLSAKGSIEEALCQRMVWHASTINGAPGLIALVSDAGSYGPTLTTLARGGWRIAIFHPPETSSTFLDYADEAFALPIHREQIEEQGVTNLPYVLNFQTLPPARGDCAITAMAQDLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XE43</accession>
    <name>A0A0D8XE43_DICVI</name>
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        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716720">
        <property type="protein sequence ID" value="KJH42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XE43"/>
    <dbReference type="STRING" id="29172.A0A0D8XE43"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="109"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="313" mass="35749" checksum="EFF417C1FDDFE5ED" modified="2015-05-27" version="1">MDYSKDKLSSFLEVNYSALPMCCIQKAEVYMLDEPSSYLDVKQRLRAASLIRDMISSTTYVIVVEHDLAVLDYSSDFICCLYGVPGVYGVVTLPSGVREGFNMFLDGFIRTENMRFREDKLSFKVSEQIDEVVKRTGNFKYPSMTKTLYHSNSTMLAGFLKPDEEVEMPATTVSYKPQKISPKYESIVRHMLHEKIPNMYTYPHFKSDVMNPLMIDQLMDRKVQTLSGGELQRVALVLCLGKTASVYLVDEPSTYLVSEQRLHAAKVIKRFIMHAKKTAFVVEHDFIMATYLADRVIVFDGEPSVEATARRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEI9</accession>
    <name>A0A0D8XEI9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">DICVIV_11928</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716712">
        <property type="protein sequence ID" value="KJH42084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEI9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="67" mass="8037" checksum="F81D62FBA5249F91" modified="2015-05-27" version="1">MMDFLIESSAFEKKTMYMYKKEYVVDNDFIEENNLLCKTILRYDFIAVLETTVGQIQLEQTEEIIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEZ5</accession>
    <name>A0A0D8XEZ5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716689">
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    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13095" checksum="F852FF803A1F00A4" modified="2015-05-27" version="1" fragment="single">VVARVAYVISIVQSVAQEAKNSWWTTILTHPLLLGVAPHYSDESILPFLQMAQAETVQVGCSVQLCEPPNTTSYYSVACYYDIPHVEARVPLYTVGEPCNQCRQGFKCDDATKLCILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF43</accession>
    <name>A0A0D8XF43_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716914">
        <property type="protein sequence ID" value="KJH41066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XF43"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF22">
        <property type="entry name" value="TESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="278" mass="32267" checksum="CC6EFA88A9818539" modified="2015-05-27" version="1">MDEHDVQLPNQCDHGQIIIASESLKCRPIGEQPSSLNSSTSSDVSQKIGIYRDTSFAEDRTIPTAAYNFKLESNKDKTTTEYSWVPVPDKSLVERYMRALPVEERPIVGSVGEQNRKSRLQFQLPLYDCNVEDARFADDKDKEVLRRFVENVRKHVIGVGQVKEITKEFARLNTNEVNDIRNDITGTVSKSVLIFAREYTFAEEKSWHFDHFACFKCDFRLGGHRYMTKNDQPHCIDCYMKYFAKSCNTCGHKIGADEKRLNYQEYHWHAKKECFQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFF9</accession>
    <name>A0A0D8XFF9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_10678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716572">
        <property type="protein sequence ID" value="KJH43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFF9"/>
    <dbReference type="STRING" id="29172.A0A0D8XFF9"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12338">
        <property type="entry name" value="RRM1_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12601">
        <property type="entry name" value="RRM2_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000053">
        <property type="entry name" value="Serine/arginine-rich splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="269" mass="30210" checksum="F9B2D80650C3AB49" modified="2015-05-27" version="1">MVREDTRIYVGNLPPDCREEDIEDIFAKFGKIRFVDIKGGRGPMFAFVEFEDSRDAEDAVRSRDGYDMDGSRLRVEFTRGTGPRGPGGRSTRGGNGGGHGRGNGGDYGSNRRGGQASRRSNYRIIVEGLPTTGSWQDLKDHMREAGDVCYADVGRDGTGVVEFTRLDDMKYALRKLDDTKFRSHEGETGYIRVREDNTNGGSRGRSRSRSRSARRSSPKYSPRSQSRSVSHSPSRSRSRSRTRKWAAFSWKVINVFAFLDTCCSYRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFT1</accession>
    <name>A0A0D8XFT1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716878">
        <property type="protein sequence ID" value="KJH41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFT1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="132" mass="15098" checksum="6A33DC2583D6D086" modified="2015-05-27" version="1">MNNPPIKVWFRRKRVFFYRFNHRYRIIVELLRLDLSPVLNSSNSYDSESFKLELSTTSPQIIRDSLPPSPRCTTPKSSGIGQILKVCNNFSDNLQQLSLSENSPRSLCTPGRDGDALLLHLFTVICSSYNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG02</accession>
    <name>A0A0D8XG02_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EGF-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716551">
        <property type="protein sequence ID" value="KJH43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG02"/>
    <dbReference type="STRING" id="29172.A0A0D8XG02"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="255" mass="27459" checksum="3C1026DF34F5DFA2" modified="2015-05-27" version="1">MVLSEIVCPDGRWGPGCKEKCRCANGARCDPSTGECKCNLGYTGTTCEESCPSGKYGLNCTLDCECHGSARCDPVQGCCDCPRGRYGTRCQFVCPAGFYGWYCSQSCSCQNGASCDPADGQCLCPPGFEGDHCESSCKNFTYGPHCQLQCDCGEHPCSPKDGTCLCPVGLSGSKCQQELTPLLQHVAKDDMVRTASINVSATTEQLVIERLANALARQGIWVLHANTKSEIRIAWRNEVTCQKIGNGALVARSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D8XG11_DICVI</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716550">
        <property type="protein sequence ID" value="KJH43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XG11"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="68" mass="7608" checksum="6BF82738D99C70EF" modified="2015-05-27" version="1">MDSAAFSFNCCNVLRQTSGVSVSNRTPSLTSSSRDMNVDRRRCPIKSQLKKEKNAGSFDDTEEEKTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHR9</accession>
    <name>A0A0D8XHR9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-derived growth factor (PDGF) family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_10674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716572">
        <property type="protein sequence ID" value="KJH43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHR9"/>
    <dbReference type="STRING" id="29172.A0A0D8XHR9"/>
    <dbReference type="OrthoDB" id="5785123at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24217" checksum="444C43FA1B57F02B" modified="2015-05-27" version="1">MFCSNPVWPGNCSISYRRNRMSDLGRTNVIEMIYIGNGRFMLNRTLNISMEEHTSCSCYDCGSNVPECPPGFVVGSDCTCQCANRNDRHNCQVCMERMCHHLTVMLHKTIQVGHSCGCASAKRSTGSGSRPKKTLSSRLLPYRCQSCGNRQWNPSECKCECESMTCSDDEVFDSDHCDCVYIRRRDKVSALSNNNAFGAVDVSTLPKLHVKRTPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHZ9</accession>
    <name>A0A0D8XHZ9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716731">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XHZ9"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="380"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="513" mass="56337" checksum="66A78920A0694DB4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716557">
        <property type="protein sequence ID" value="KJH43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ERP44"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="85"/>
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        <location>
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            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="48621" checksum="A63EDAA0A637E3E9" modified="2015-05-27" version="1">MFGGNWCPYSQELLPIFSEASYMFKQIHPSFDVIWANVECMEEVHLCQLYFISKYPTIKIFIRGDMMNKEYRARRAVDDLVHFVAEQYEGSIREFVDDNDLMNNMNTSAHNVVAYIKRGNDAYQNFYSIAQLLRDYCTFWIQEEKMAENLVKFSLYYKPPEMNNKLDFDGNLHNYTLLKQWVTDKCIQLVREITFENAEDLTEEGLPFLIYFRDPRKKEDDKFFTEILKKPSNCCGAYEGGSKILLEPIQLFDDQRKPSDSGKVLCCDIEERVVARELYEQRMTVIPLLADGFKFAHPLHHLGKTIEDLPVLAIDSFTHMFIFPNISRLSERGALKQFVDDLYSENCHKHFHGEIVEEEELPQNPVTEQSSNPDSKERQENESGLEEKDVFLKSIFRELKPSEKRYSLLDKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XII0</accession>
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            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJA1"/>
    <dbReference type="OrthoDB" id="5867883at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="159" mass="17436" checksum="041ABE7095A3EA04" modified="2015-05-27" version="1">MTLEDGLVKDGLSYRADLFTINTLAAIYTYGSLVWLVFLVAVAINSVRARPIKKTKQRDYELLHTGFDRQLSYSARDSMMSSRSGLEKRSRADSSLSGNSQIDKSQQSAKPKKSNEETASSKLMGSAEEKASEKDKTGSSGKSANRTAKDVNESSKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJR3</accession>
    <name>A0A0D8XJR3_DICVI</name>
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        <submittedName>
            <fullName evidence="8">SURF1 family protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716648">
        <property type="protein sequence ID" value="KJH42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XJR3"/>
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    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="752" mass="86246" checksum="E01C5E5FE529013D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XK28</accession>
    <name>A0A0D8XK28_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_09867</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716499">
        <property type="protein sequence ID" value="KJH44107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="287" mass="32820" checksum="BAD8BCDF08D59529" modified="2015-05-27" version="1">MSLSEIFTINVKHIIIALLQGQAITAELNRRGATVYMLVRDEQRGRDSIQRLQKEGCEPNRLILRFVDLAHFQTLRDFAKSFMEEVPRLDILICNAGVLRVPVFTRTVDGFEKTWQCNYLVELMLPLLSKSEDGRIINVSSVLYEYADSVSLKVVNNLEHYGGMIAYSRSKMAQVMYTRYLAKLLEEKNLPITVTVCHPGNVDTNILKESGYLWLSVVFRPIVWFILKTENDGAQMPLYLALSKTILQCNGQYFRNFAIHEVIEKCKPIDACEALYVESRKAVGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XL66</accession>
    <name>A0A0D8XL66_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase family M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_08586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716411">
        <property type="protein sequence ID" value="KJH45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XL66"/>
    <dbReference type="MEROPS" id="M01.A16"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000028">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF21">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="8">
        <location>
            <begin position="273"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="359" mass="40969" checksum="AFA567B897F1D412" modified="2015-05-27" version="1">MRLQSKQNFSIMDVLPPQHEGCDKEEELHSNQDKKKQDILLVPMPTHTLPLHYNLHLDFTNAANKIIRGSMTIELEVLENSTDNEILFHVGPNVIIDRIRLRKEGKRVYPKTLRIEESKMLARIVLKESLKNGVYLLEIDYNTTICNEENGTQCDYELDPLNNSLVSAFTTKFEPTHARSFLPCWDDPGIKATFNITVMHLSKYVVLSNMPPNGSKKTPEGKTTTSFEQTPPMSAYSLAFAMGQLVPLEMRTGRNLPLTLWIHPEDLLSAQFAANFSPVVFDRLESELELLYPMPKIDLVAARNFPVDGTKNWGLIIFDKNSVLLDAKLEDSPNMTVDRLYHEYNIKKIITSQIAHQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLC8</accession>
    <name>A0A0D8XLC8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716463">
        <property type="protein sequence ID" value="KJH44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLC8"/>
    <dbReference type="STRING" id="29172.A0A0D8XLC8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="180" mass="20999" checksum="1A9DD1CAB57B47B0" modified="2015-05-27" version="1">MSCAESYTSYYEWPTQPSYAPYPRCEPPRNINPPTSTISHVYGNIPPSSTGDLWTTTAQFPHQQTTVTNTYKWMHTKRSHKPAAPKRKVVDENGTNRTNFSTHQLTELEKEFHTAKYVNRARRTEIAQNLKLNEAQVKIWFQNRRMKEKKREKEKAFLARNVMPWDNSSPSSDDVKLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLJ5</accession>
    <name>A0A0D8XLJ5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_08456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716404">
        <property type="protein sequence ID" value="KJH45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLJ5"/>
    <dbReference type="STRING" id="29172.A0A0D8XLJ5"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000626">
        <property type="entry name" value="Actin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="339" mass="37364" checksum="53B713C42B27E33D" modified="2015-05-27" version="1">MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKREHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGVVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEAMFQPSFLGMESAGIHENSYNSIMKCDIDIRKDLYANTVLSGGSTMYPGIADRMQKEMTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716403">
        <property type="protein sequence ID" value="KJH45513.1"/>
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    </dbReference>
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        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="186"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="KJH45513.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="235" mass="23262" checksum="1CCC1BFFBE1C18C6" modified="2015-05-27" version="1">METMLRFEFKSIRENSIPRERRQVEGVCSCQAGSDCPPGPKGIPGLAGTDGETGRPGPPGETGPTGVVSEVMQTKPTGCRQCPSGPPGQPGYMGAPGEQGHEGEAGQLGIPGRPGSYGMMGMPGDNGAEGPAGNMGEAGIPGMEGVMGEKGPAGEAGPTGAIGPKGPPGYPGRDGVAGMMGAPGPAGTPGNPGNPGFPGNIGVVAENGGPGNDASYCNCPTRKQLKSKRTKANLQ</sequence>
</entry>
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    <accession>A0A0D8XLT1</accession>
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            <authorList>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716455">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="382"/>
            <end position="545"/>
        </location>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>A0A0D8XM61</accession>
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716396">
        <property type="protein sequence ID" value="KJH45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="105" mass="11909" checksum="972E6DB58A0C07D5" modified="2015-05-27" version="1" fragment="single">IEYKCPGFSIPYPSSRFPQKCYLNQPWTCGARQCMPSNVPNVNICCESTVFRQREMNPCPLGWSPINNVITYCTPSYYSSTCPGFSSCLRSEVVQQQFLCCIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN06</accession>
    <name>A0A0D8XN06_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">DICVIV_08038</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="133" mass="15274" checksum="842BD21DCE17BBD5" modified="2015-05-27" version="1">MTHYRYYPDSKSFDVFIDNLPGYPDNIRLGSNGTLWVPLPAIRSEYDNWFAVRPKLRSLLTMLLSSHSIHYFAQWMAPKYGFVLKMDSESGMLLESLHDRTGHISDVTVAVEDGHGNLLMGSDTQYYIARLKL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <source>
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    </evidence>
    <sequence length="153" mass="18664" checksum="56E5E95F27174AB7" modified="2015-05-27" version="1">MSIDAEITRINEGIMKIHLALYKFNNHLSGILIGINEKLSDFDKKVDNAVERVNRVKKLVDDIFEHFPNDVIYYSVILMMVFILDLFCLYLIYYIYKWIVEREVHFDKEIRWYKRKVYSLIDNERWDQYLYMTESWKGVLSDPYYIEHSRISE</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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            <strain evidence="3">HannoverDv2000</strain>
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            <end position="27"/>
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    <sequence length="112" mass="13091" checksum="8461A7C5EC44513E" modified="2015-05-27" version="1">MPKKKGKQSSSAEETPNDVTASGTSSPHLMKKLQKVSAYERAKKIYEKIQYEKAQEKAIRLQERERKQELLKMRVRAKRKRNKTLRRCNKKGQPNLNAQVEIILGKLEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ39</accession>
    <name>A0A0D8XQ39_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase D domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716380">
        <property type="protein sequence ID" value="KJH45904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ39"/>
    <dbReference type="STRING" id="29172.A0A0D8XQ39"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF12">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39842" checksum="D8C157055F3535EF" modified="2015-05-27" version="1">MLGVSRITQVKEGTRRYPSGVLHTKSWVVDGKHLYVGSANFDWRSLTQVKELGIAVFNCPCLADDLRKLHKIYWKMGAPRAKIPKSWPTTYDTSAYHERPTTVPQRNGNQAVYFSASPPGFQSCHRESDIDAMVKLIDEAEKSLNMAVMDYAPTTLYLKPLNSHLNLTNSLKGRAHFRWHGRLDEAIRRAAFDRQVKVRFMLSRWSHTYARFYSYLHSLQDLSSQLQCLKINGKCIRRGSIEVRLIQVPDMQYGVIPYSRVYHNKYFVTEKAVYVGTSNWTPDYWKYTAGIGMIIRPDDISQKSFIVKQFNQIFERDWNSNYTIPLSRFDNDGNWVNRTRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQ53</accession>
    <name>A0A0D8XQ53_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716467">
        <property type="protein sequence ID" value="KJH44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQ53"/>
    <dbReference type="STRING" id="29172.A0A0D8XQ53"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="216" mass="24828" checksum="8BD4E9EC0E982281" modified="2015-05-27" version="1">MVMQTVGTQLKLVRNMHGIHTPRGQELLKLILNFLTPLTSSVDKNARMNISEDVTNGILWELVHTLLKTQSDPVCSAIPDSVHFGRSLNTLVIRLCVRVDRTIFFAGCTRCLMTSLLEDPDGDAGQMFIKCLYKWADIMSKQKSFIDMELYLRCSNRFYELIHPVNSFNVFWRKLLTRYFIIKTFDETARSKRSCKCDCSCILVQFRTSLPSKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQC2</accession>
    <name>A0A0D8XQC2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716377">
        <property type="protein sequence ID" value="KJH45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQC2"/>
    <dbReference type="STRING" id="29172.A0A0D8XQC2"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF112">
        <property type="entry name" value="LD11247P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="106"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="504" mass="57298" checksum="DC872A390AF97F6E" modified="2015-05-27" version="1">MLQRTTMEDDVNVGEYINMSLTEKELIVSGTSKIWLDDIAGCHVGYGDDSSENNDVVVENFPLIKNRRAYQQIRMKLPSRDDAQRLYQCLSSKIRRKLAPHLLQKVPCNRVLLLINPFSGQRRAKELWAKYGKYVLQAAGIEVNIINTEYVRHATKIIQELDIDLYDAVLVDGGDGLVTETICGLLMRKDRERALKLPICHIPGGTSNALAAAICYACNEPFSSRGIFITECCLMVTRPRYLPLRIYVVDTEYDGTRPMFMSATWGLIADIDLGSERFRWAGMIRLHMEAILRILQLPTVATYRARLSYIPVNCKMISRNTMLKYNCKRNRFGKGHFKFNTVEQTNGWEQILNEDFSSMKDALEGTTTMNMPPLDQPLNEKWKVVEGDWVMANVSTLSHLGSDIPFLPSARLDESVMYLTLIDWNTIKSRLHIAHLFSFMQSSKHFDHPCFQVIPVKAVRVEPLSDGGHFAIDGEPCRSGSSFQVVPTKYCATVIGRKEVVQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XQK9</accession>
    <name>A0A0D8XQK9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_07849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716370">
        <property type="protein sequence ID" value="KJH46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XQK9"/>
    <dbReference type="STRING" id="29172.A0A0D8XQK9"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="38"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="383" mass="42289" checksum="4A88682216B70C27" modified="2015-05-27" version="1">MLSRTVRPLVITGNKLLAAHRYSVCAPKPVPEIAHKLKITIIPGDGVGPELIYTVQDIVKNTGIPLEFEEIFLSEVHYSRSASIENAVKSISRNNNVALKGAIQESAVLHTEGELSGLNMRLRKALDLFANVVHIKSLDGIKTRHGKKLDFVIVREQTEGEYSSLEHELVPGVIECLKISTSEKCGRIAKFAFDYATKHGRKKVTAVHKANIMKLGDGLFLNTCHEAYVFLACSIMFIEVAKRYPKIEFDSMIIDNTCMQLVSKPEQFDVMVMPNLYGNIIDNLAAGLVGGAGVVTGQSVGSDYVIFEPGSRHSFQEALGRSIANPTAMILCAANLLGHLHLKEYGDALRTSVEKVIREGKVRTRDMGGQFFVIEFRNYKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR40</accession>
    <name>A0A0D8XR40_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dual specificity phosphatase, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_07651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716361">
        <property type="protein sequence ID" value="KJH46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR40"/>
    <dbReference type="STRING" id="29172.A0A0D8XR40"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF2">
        <property type="entry name" value="PROTEIN CBG09952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="138" mass="16071" checksum="13BF90E32EE9C450" modified="2015-05-27" version="1">MVQTRFCTTINLIPGFRIIVPGRMKVLHIPILDDESTDLSPYFTVVFKEIDNARKSAGRVLLLCAMGISRSATFAISYLMCIEKMSLYDSYKHVQYCRNIVCPNVGFFKQMIELEQKLRKMYRFYKKFDCPANEDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRR6</accession>
    <name>A0A0D8XRR6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_06711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="KN716317">
        <property type="protein sequence ID" value="KJH47195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XRR6"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000016">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-7 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000041">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF243">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-7 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH47195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="300" mass="35142" checksum="E6E1246107072263" modified="2015-05-27" version="1">MRILHKDGFSQQDLEMIRPVVYSNCIHSMLAILRAMFHLQIEYADSERVRDSQLVFATVHANKEELTEELAAAMQRLWADDGVRECYQRSNEYQIDDSAKYFLDNLPRLSSLNYIPSEQDLLRTRIKTTGITEVLFELKGLTFRVIDVGGQRSERKKWIHCFDNVNAIIFISSLSEYDQTLREDNCTNRMQESLKLFDSICNSPWFADIHFILFLNKKDLFAEKIQRSPLTICFPEYKGQQNQTECINYIQWKFEQLNRSSQREIYCHHTCATDTNNVQFVLDACLDMIIAKNLKSMGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRZ0</accession>
    <name>A0A0D8XRZ0_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716346">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
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            <end position="196"/>
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            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="256" mass="28862" checksum="EFB2588F274A33DB" modified="2015-05-27" version="1">MFIGGLSHETNDESLRTYFTHWGPVVDAIVIRDPTTKQSRGFGFVTFATIASLEAAMMDRPHIIAGKTVDSKRAIPREQMTPMFPPPFFSCEHAPGCKLLLSGINWDYHSVDTLRIYFEKFGSLDQVEILGDRRGFGFVVYEDKQSAEKCLSENNGRHIIATKRVDVKPFPKRSSTYWRRNPDSSNSGKTVGATPPAPPTLYDQLAAMNLNTRATQYDEDSSYGGTTTEVCSIFFLILKCRFYIENLCSIVLENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSN1</accession>
    <name>A0A0D8XSN1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CIP2A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716337">
        <property type="protein sequence ID" value="KJH46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XSN1"/>
    <dbReference type="STRING" id="29172.A0A0D8XSN1"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="CIP2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048701">
        <property type="entry name" value="CIP2A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161:SF2">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21044">
        <property type="entry name" value="CIP2A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIP2A N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="359" mass="41417" checksum="8787287E5AC8C16F" modified="2015-05-27" version="1">MELSQLEALYNVRIRRYLCSELHLCESVFDCLKLSLREQLGPQNLIDILRLLQTSYKTFSKRIIKLLSHDSRIVVVSSLVLVGYLEEKVRDMVYCSQNIRETFQCVFNVLIMGDKDCLMTRHIASDFLRRLVVSETNTISPTPVITSTGKDIMNYEFFDRCIQQTAELLIVLDPRMEECIKAKIECGERVSDVISVDQLLTIIDTSVKTTLETSKQHVIYQCRRILEGLRLAEVCSSEEDLRFRLLEVTTAALCAHILESQYITNPVLIFIEKPLSQRTEKIADWSIYGVAVVLVLLKLLASLKDFSKLHKDQYWNSLKDTRLVSFLAYSLVYGDSEMINNALVLYSYCSQLHAFPNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTC2</accession>
    <name>A0A0D8XTC2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 13C-A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_06901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716324">
        <property type="protein sequence ID" value="KJH47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTC2"/>
    <dbReference type="STRING" id="29172.A0A0D8XTC2"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ankyrin repeat" evidence="7">
        <location>
            <begin position="141"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="431" mass="49651" checksum="543724D2C9CF3A08" modified="2015-05-27" version="1">MEIRPSTYRLCLVIEKTSILYAYLYKISVSDLIYKKIFTEATAQLLAHNAPVKVKNCDGWNPLMEAVSYGDRQIITEMLRKLKAQSRTGFSSRKSHLVKMLEDIDDFYLELKWDFQSWIPLLSRMLPSDVCQIYKKGTQLRMDTTLADFNERRWERGDISFVFNADAHHEGDELIIMDNNSKVFQRVRHEESEAEVDEEVDVLMSSDIVSAQISTKTITFRQAFSGWIFKHAREQMFQQEQIGDYNVNFFLVEGMKLVSRKRREHLTADDIKRNKSFMQSLASGAAVCDDDFKSFQHRKSLAPPGRMPTTWEEYVGAAPGAAPPLGRAQVLKQNEKHLTALIGMSEEFPMSIEVLLNILEIVAPFKHLDKLRRFCEARLPPGFPVRIEIPLLPTISAKVTFQKLQLGINLSDKIFLVPTSYREDPTRFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XU66</accession>
    <name>A0A0D8XU66_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_06640</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Has roles in embryogenesis and ovulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. Interacts with V-type proton ATPase subunits a1 unc-32, a2 vha-5 and a3 vha-6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716314">
        <property type="protein sequence ID" value="KJH47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XU66"/>
    <dbReference type="SMR" id="A0A0D8XU66"/>
    <dbReference type="STRING" id="29172.A0A0D8XU66"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="535" mass="58854" checksum="40BD9BDDFE225F4E" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUW9</accession>
    <name>A0A0D8XUW9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716272">
        <property type="protein sequence ID" value="KJH48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XUW9"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="97" mass="10801" checksum="F98B6856AB1CF3E8" modified="2015-05-27" version="1">MQELRVIFSIGQRSAAQSQCCRTAHNDKEQTCATKDRGHSVVVCCRSAPPNLSVYQQNHYICEIRSAKGAPKNPTKPKLIVLRDFASFFIFVGHGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP2</accession>
    <name>A0A0D8XWP2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716277">
        <property type="protein sequence ID" value="KJH48174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWP2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8186" checksum="868E86216AE12481" modified="2015-05-27" version="1">MITCVASADNCGSEKCVPFKSLGRNIMKILVISDIAVPRLVVANSKAWDIMIKSINQRKMFDRFAGGEQIALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWP5</accession>
    <name>A0A0D8XWP5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TCP-1/Cpn60 chaperonin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XWP5"/>
    <dbReference type="STRING" id="29172.A0A0D8XWP5"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19744" checksum="B5AB4244A05371FD" modified="2015-05-27" version="1">MDLGEDKFTFVENCRDPKSVTLLIKGPNKHTIQQIKDAINDGLRSVFNTIIDRSLLPGAGSFEIAAYCMLTKELESLKGRVKLGVLAYANALLIIPKTLAINSGFDAQEVIVKLVEEREAGGDVPVGIDLESGLPMPPVGIWENVIVKKNCISSSCVIACNLLLVDEVMRAGMTNLKTSQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XX29</accession>
    <name>A0A0D8XX29_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Integrin alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_04777</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XX29"/>
    <dbReference type="STRING" id="29172.A0A0D8XX29"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="13">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="14">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="14">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="15">
        <location>
            <begin position="366"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="742" mass="84763" checksum="72F5C3939DFD6B3F" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXF6</accession>
    <name>A0A0D8XXF6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SH2 domain protein</fullName>
        </submittedName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716256">
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        <property type="term" value="F:GTPase activator activity"/>
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    </dbReference>
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        <property type="entry name" value="RasGAP_CS"/>
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        <property type="entry name" value="RasGAP_dom"/>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="176"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="353" mass="40692" checksum="6307748C2F1BA3E8" modified="2015-05-27" version="1">MQKYNQEAKKLRISSNDHSSEWLEMRCEETGTLSVQITLWQQLLRGFSSTFHGQIRVDIDEGWTNGASRWFYLHPRHNDHLNEAKDHEMLRKLGSRNYISTNFLQKLMGRIPKHLIYTDDQKQQLGDMKLWLSYTADHVLPIENYSYLMTSLATSPNVGPFSASLACLLEHLPKVDLGVVARPIVHAMINTQQLRPLLNALYAADIQQCQDLNTLFRSHTLASKMLYELLKIYGHSYLIDTLKPVIDKIYKERRCCEVDPNRMPQGETDEKNLRTLLYYFSLVFACITESTSRCPSSIRVILSDLRMVVRQKTGKLDVEFLALSSFLIMRFFAAAVLSPKSFGIKSEQPKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYF7</accession>
    <name>A0A0D8XYF7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716231">
        <property type="protein sequence ID" value="KJH49530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYF7"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="286" mass="34014" checksum="2485BC32C31E40FF" modified="2015-05-27" version="1">MLSRNKISYLRAVVMIEFVTTSSRHSHDALRCNDIEYIGYGKEGKAYNRKETYKLDPVKLRRPYRFRAQRFFSNENNKQNNMRFIDGFVSFSLLPLSHNKIEYRGDNSHFTTKCHDSRPNEHLEEQKPLIYVKKDQSVTIHFPTVLLGTSFLRMSMWILYGCFLVTFLYLITVTNIFEKNRNVAEYIKKASHVKYPNRVLLHPEERQRQNQDNDQVITSTRDIFDTCPFVAPDPWDPEIINYVDVKYAFWLKGKEFNDKKKMSGKTGYQVTKYEETRPNFMRKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ57</accession>
    <name>A0A0D8XZ57_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium binding EGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_04828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KN716247">
        <property type="protein sequence ID" value="KJH49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZ57"/>
    <dbReference type="STRING" id="29172.A0A0D8XZ57"/>
    <dbReference type="OrthoDB" id="10060424at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000973">
        <property type="entry name" value="Transmembrane cell adhesion receptor mua-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010423">
        <property type="entry name" value="Pvs25/Psv28_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF28">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06247">
        <property type="entry name" value="Plasmod_Pvs28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="234" mass="25884" checksum="23AC80DF029DFF79" modified="2015-05-27" version="1">MESFLDLRANLNHLRKHDCSKHASCIDTIDGFTCRCHDNYRDESPSPSTNPGRVCIRAFVPDPPECDVSDPLSCDQRKSEVCVFVSGTYKCRCASGYTRLPDGRCLAINECEHQRLNTCGQNAECIDLAEGYTCQCRSGFADVSPAGQPGRICKARVNECSNKEKYRVDCDENAICIDTDDSFTCQCRPGFADISAAFNRLPGRRCIEAVNECSVKSLNDCSEFALCEDAKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZD8</accession>
    <name>A0A0D8XZD8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAF1 family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716242">
        <property type="protein sequence ID" value="KJH49222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZD8"/>
    <dbReference type="STRING" id="29172.A0A0D8XZD8"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
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    </dbReference>
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        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
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    </dbReference>
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        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="487" mass="55832" checksum="0163FF3ECADD5E27" modified="2015-05-27" version="1">MAIHVGRDNFHYLLPDIMRSVSSAAFISVDFEFLGSPSTSGKDSRSLFDTPHEQYVKICSVVKRFPPCQLGLACFYDFETGIGTGSRYSVDVYCITLFKRSCKSDFSVSPATIRFLVQHGFNFNKFVTDGVTYSNRSELAKLEDKISKDVYDLEVFENGLGERVRSLKMRILCEMVDESEIFPDHCTKNASSRRHSVVIHLFREENEGYEFDECLWDRPLNSLEETLVVFALSQEFPDFEFHVNEKRTLLYVGRRPVMYYVTNEEKLIRRQESLKNLLQEIAGISSVFSRIFERKPPLVAHNCFLDLMYIYNCFHAELPVTYAEWKKEVHALLPIIVDTKILAGALKDLHATDSNNKRQPSPVILPIRTSLVINGEDESVSLWKRQQSYHNASFDALVTGDVFIKLAHLFVFTKCSHILDKSLPLHKLFFAVRTEVANKVPFPLTNVDCCKLVIRTARMLLVLVQALSKFITVDIYCGCPQTLFNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZT9</accession>
    <name>A0A0D8XZT9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716290">
        <property type="protein sequence ID" value="KJH47846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZT9"/>
    <dbReference type="STRING" id="29172.A0A0D8XZT9"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="5">
        <location>
            <begin position="104"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="244"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="515"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="687" mass="77183" checksum="AD3CD318D8C3B8BA" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0S0</accession>
    <name>A0A0D8Y0S0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_05709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KN716276">
        <property type="protein sequence ID" value="KJH48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0S0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0S0"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000124">
        <property type="entry name" value="Defective in cullin neddylation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="308" mass="36022" checksum="7333ACC50D31BF77" modified="2015-05-27" version="1">MIRTPFDFFVVFRGLILAQRPAKRVRLSSENNQYECSYLSFTTAIVDSTMNKLRSEQKTKIKNFVAWTQTSEQVAYACLSRANWNMEYAVDLFYQSPRMAQEQQQPSVDKYKLEKMFSVYANGIVLIGPNGMLRLLNDLNLDATDRRVLILACKLKAQTQCEFSWEEWQQGLSALRVDSLDKLRDRLQELDEDLVEPAAFRELYSFTFLYGKLSSQRNLDLETALAYWKILFKDKFPLLSLWEEFLVTEHGKAISRDTWNLLLDFCLTIHPDLTNYDDEGAWPVLIDQFVEYAREKLKLPSHESRVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1C6</accession>
    <name>A0A0D8Y1C6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1C6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y1C6"/>
    <dbReference type="OrthoDB" id="2347980at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061138">
        <property type="term" value="P:morphogenesis of a branching epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042345">
        <property type="entry name" value="Btbd7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="689" mass="77988" checksum="B9915655D415F0B9" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y215</accession>
    <name>A0A0D8Y215_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_03626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716212">
        <property type="protein sequence ID" value="KJH50187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y215"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH50187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="74" mass="8636" checksum="CBA35D09B2C60085" modified="2015-05-27" version="1">MMKHLQNLSPQCTFELRPRELTGFAIGSAFCNRCHLWLCKLKAAFYSIVLIDFYSILMRYARKIGLCIALIDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y337</accession>
    <name>A0A0D8Y337_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="16">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_03266</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="16"/>
    <dbReference type="EMBL" id="KN716202">
        <property type="protein sequence ID" value="KJH50592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y337"/>
    <dbReference type="STRING" id="29172.A0A0D8Y337"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000115">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="247"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH50592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="505" mass="57436" checksum="860FDFDECFA8BA09" modified="2015-05-27" version="1">MGGCFSRHRNPASGDSMGGGVLERVDTTKFSSASQTMYLVNNAGDREVHMVEHSTPAQKEILVALYAYDSRADGDLSFKKGDIMYLLDQSNCDWWYVRHQRTGSTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLANNLPKGTFLIREREADGREFALTIRDSDDIRGGSVKHYKIKRLDHDQGFFITTRRTFRTLQELVAYYSEMADGLCCQLTFPAPRIAPTRPDLSHDTQQNWEIPRNQLQLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLGEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMCNGSLLHYLRNEGAALGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGEKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGKFLLAIFTSITQSCITVMLKCWDKIPERRPTFDHLFHFFDDYFVSSQPNYVPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3H3</accession>
    <name>A0A0D8Y3H3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3H3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3H3"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="6">
        <location>
            <begin position="146"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH49136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="458" mass="53341" checksum="F89EFBB5CE8D1CE0" modified="2015-05-27" version="1">MIEGKSDSAIGTERAAASMNDVKINERVVVWRVVNNEKRRVLATLLKKRICEPKIASCDLHGKIGKEDRGTIQEEYEYFVHFDGQDRRLDQWISGEQFIELAPKLSTVDIGVCDVRLRRKRRRENEDELLSLEEIGAQKDHHRKAHPEKNIEKIVFGRYEIQCWYYSPYRLKKKAVDRLFICQNCLLYTEDRRRFACHLANDCKQMCPPGEHIYEENNIKVYEVFGALEKLLDTNSVHTSYPSSIDCPASLRMAKLNFYCQRLCLLAKLFIDHKTLCFDVENFIFYLLCEVDDDGNHIAAMFSKEMYSANNLACIMTLPCYQRKGYGNLLIQLSYEMSKRAKYPGTPERPFSDLGEISYKKYWLWVLLEFFDSNAMRKVEDVTVDDLEALVGINKEDIKDTMGPIGLLSHLKGGTYIVHNPKLDQDSSVERPGPPLRRLNAKYLMWNAKTFDRPKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3H7</accession>
    <name>A0A0D8Y3H7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3H7"/>
    <dbReference type="OrthoDB" id="5818871at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553:SF1">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553">
        <property type="entry name" value="PROTEIN CBG19621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="441" mass="50518" checksum="BA90D39274EEBF61" modified="2015-05-27" version="1">MDLVGRLLRQMLQGSDIGNATSGTNRSIDVLCANCISPYEPIACVRSGLISLVGIVTASFAFVRIVHLHATTSSHIRLLLFYILCLHCFAASFEWLLGWTTKLSIFISYTKVIELVIICYLYLNMASRMIQWNSIAAKRQVKLIKAFLEQIADMIFNFVYFMSIYVTFLYVSFRLCFSALFLMFTYFTMFLVTGFLLSFEPWKDCHAPYWIWFSAGEFIMVQLMVCSFLILIRRMSRISDVLSIPSKQRRDLTSLFWIFETSAIADLCYHILLFIMGDDVKGCSGVFDHDQVRYSLLKLPYDVVSFLIPVWTILFVFRAPLKSNSHDDHWTGLFYSSHAPSLASVADIVVVRNWQRRYRPITQSSQYDRPVLLGRRIETARRLQTINSTSPVLVGRCITTPRSLVSSPLYSIPEEMVNCEHDTSVVVGSVDKLPIVPLMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3R8</accession>
    <name>A0A0D8Y3R8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716185">
        <property type="protein sequence ID" value="KJH51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3R8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3R8"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
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            <begin position="337"/>
            <end position="359"/>
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            <end position="387"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="484" mass="53485" checksum="97769EF85E3DE836" modified="2015-05-27" version="1">MGSSGSGKTTLLNVLTSRNLSGLNVTGSITVNSQRISKWRLREVLQHDMFIGTLTAKEHLLFMAQLRMGSAYTAMEHSIRVDDVIRMMGLTACAETLIGVPNSLKGLSCGEMKRLAFASEILTYPKILLCDEPTSGLDAFMAGHVVSALRRLADIGMTVIITIHQPSNNVYSLFDDVCLMACGYTIYHGPTDGANQLLAKCGYPCPSYSSPADHQIRTIAITDKHRTSSIKTIAICAIITGLVYYNTAITSQTIITINGVLFNNVRNLNFMLQFPAVSAITWELPIILCEISNGIYTSTSYFIGKNLAELPQYIILPVIYNTIVYFMAGLVPSLSSFLFATLICMLLTNVAISISYATATIFKTDTVATAVLPIFVIPMLAFGGFFINDKTIPYYFTWLSALSYFKYSYEGLAINEWEAIKFIPGCFNNTLKYTHCPISGSEVLESINFNGNNKWTDVIILSSMILIFRLISYLALVIRVFYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Y5</accession>
    <name>A0A0D8Y3Y5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_03139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716199">
        <property type="protein sequence ID" value="KJH50699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Y5"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Y5"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006686">
        <property type="term" value="P:sphingomyelin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01610">
        <property type="entry name" value="PAP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF23">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH50699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="366" mass="42288" checksum="3AE35EACD943DEB3" modified="2015-05-27" version="1">MPGISPITQGEPFPMNSFIAAPRQCDCPSKVVVEQRCSCRDESSTICIPLRAYENLEYRPERLKTFVTIICFLIVMLINHFVLAVISDIISRLPLPDLAHSLIEQYDTPRHLADVFASAACIVLIIVCCIFHKYRWIITRRLFYIGSVLYIMRAISICVTHIPSGFHDYEHDICVPPNSDPNPSLYNVMSKFISISATFGLQIQVSQNKLHCGDMLFSGHTTAISTSCFFLNYYTPHSLWPLKLVAITSCIIAMCCVVISRVHYSVDVVMGYWISSIIFTVYHSFCEVPHVLRPRNQPFRRLFLFWTMFELERHVPEGRIPNKLEWPLPWPKIIADRFEEWNNQSNDTTVGRVARWLSEHRIKLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4Y7</accession>
    <name>A0A0D8Y4Y7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitinyl hydrolase variant UBP zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4Y7"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4Y7"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitinyl hydrolase variant UBP zinc finger" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="132" mass="14975" checksum="7E8CE07D889ADB64" modified="2015-05-27" version="1">MAVPQDAEETLCPEHFRSQLGESSFTVPDISTKVFKEECTYCFRTPFHQGGLFVCLKTYACFCYTHVGLYAEQSGNTLFLHVFSRKVDLESEEESDGEPKDKITRLAIGVDSGFDTKKFSSLHIRLEYNVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5D3</accession>
    <name>A0A0D8Y5D3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">26S proteasome subunit P45 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_02646</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716189">
        <property type="protein sequence ID" value="KJH51184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5D3"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5D3"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 16" id="KW-0647">Proteasome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="501"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="614"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="734"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="848"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="948"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH51184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131942" checksum="B22713E934B6FC5A" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5K2</accession>
    <name>A0A0D8Y5K2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5K2"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="99" mass="11874" checksum="685437392E677CD5" modified="2015-05-27" version="1">MAFRYLIAHQILEEPTGRRIEKYFYLIHFQVPVHFLYKHILHKYTTRPSFNGNNHVGFPLVNATRDWFSLRLPWYGSFTASDFEECITIIFIVFEVDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Q2</accession>
    <name>A0A0D8Y5Q2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_03925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="KN716220">
        <property type="protein sequence ID" value="KJH49896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5Q2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y5Q2"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="236"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH49896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="253" mass="28685" checksum="A2585E6F83B4AB6D" modified="2015-05-27" version="1">MAGIRTHGNLFQFEQKPLVIVYYNVDYLKDPKGSNYWRNRVLKVAKDYKRKVHFAVSNKEEFSSEVDQNGLSLRKDSDKPIVAAVTNEGKFPMDNEFSVDNLKTFVEDLIAGRLEPYMKSEPIPENTGALKVAVAKNFKELVLNAKKDVLVEFYAPWCGHCKALAPKYEELAEKLVDEDVLIVKMDATANDVPPLFEVNGFPTIYWLPKNKKGSPVPYSGGREVDDFISFIAKHSTDGLKQYSRDGKKKKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Y9</accession>
    <name>A0A0D8Y5Y9_DICVI</name>
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        <submittedName>
            <fullName evidence="16">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_02418</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Orphan nuclear receptor.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
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            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH51404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="602" mass="68476" checksum="852E758730BB3BD3" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5Z4</accession>
    <name>A0A0D8Y5Z4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DM DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_02423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DMRT"/>
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    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF119">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR DMD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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                <person name="Rosa B.A."/>
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                <person name="Hallsworth Pepin K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH52029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="414" mass="47490" checksum="6AAC8CD910BDF84B" modified="2015-05-27" version="1">MFLLLVLLHSLQPIFISPMDVSFNRMLETNQYLLISQYACQTTFESNIKDNSCPKSFSNFYMRSSETGCIHPIRVHLIRDPEEKRPPRALYIGQDYRARSIAFVDDIQIPSPPVTNNTSFIYSRSIIFSNRTHKHLNRMRTEFTLYDQSYQLLYLITRNSFGSLTCAVYRLLNLFPGGNNRLMFDVINMNDFVMHPLNKVRSNWIEDPYSENVFYTTSNGGVTSIHALPMNRLLFALQDGIDGKRVFSYESSSRSIVSISGGLLFSQHLRSGYSTVYIRSFANMTQQPVGLSCGLHTGYHQVDGGQPITILIVKNWDYCLLRDGLLADSKSCLQEREQWMVKEGLVSESLSFWSTTLIIVLILLSTVSESLSFWSTTLIIVLILLSTQEAGNFRYPSFLGQYLDMDISVDRWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y7T3</accession>
    <name>A0A0D8Y7T3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716171">
        <property type="protein sequence ID" value="KJH52054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y7T3"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="142" mass="17168" checksum="C08AB98E47B991A9" modified="2015-05-27" version="1">MPTMLARNWDSWEGDEYFVPCKGESKCRPVIDEAVQKQWLSELSVSVEHECMTIFYAKTLYEQHKNDDLFNGKTSGSRNSVTELLRKKTNQYFRQRDYRRCGLILRRIFHNKTEKRLQRWRTIPRSLEKFQNDEISDNIEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8C6</accession>
    <name>A0A0D8Y8C6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716155">
        <property type="protein sequence ID" value="KJH53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8C6"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="339" mass="39064" checksum="FF87EDD2E733E71E" modified="2015-05-27" version="1">MIVSVLGANSLLAQYLIRYIQRLHNSSWKIYIWSYSIPFHPRISGITIYPLKQFVGLERLYNAVKYADIVFNLHEAQDLTLLPDKKQLEVHNVNFVRSLLSCARCPLVHLSSIFLQCSSYWPNVYESENEAEKYTVQWPFPSYCLSKWEAEQIIANSSVDAYIIRCVPVYGEGDTHSILTDLIKYAKNGNITSLGDGEGVLQMAYAENIVVGLWSAVKKLLPYADPQSGTSKDIVNSPARKRHIIRETIILADETPKKNVITLFKPLLANGKRFVAPSRIPFLTFCYFYYMVLAILNLLSKVLYIPRFIRTESLNRCRMYYNRLVSEDIRTYSWNPYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y8M2</accession>
    <name>A0A0D8Y8M2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_00765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y8M2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y8M2"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000017">
        <property type="entry name" value="Sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH53080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="453" mass="51757" checksum="E02678C06AA3E36D" modified="2015-05-27" version="1">MSSIYGEQNHLSAIFRNFKDSCLASERVQDNTAKLIELDNRRQKLREALRSLKNPRQESTTWLALTESLMMEFTVADSVKVLQQSVEKTEDDYALVNKQVREELNNALRAKSEKDLKARGFDLKPINKAGSLIYDWEAKVDNAEVERICEYPLDIFLEEVDQKAVVVFGEKDGVKLRYYVSGINGFRVSGTKILFNETEQNIFEYLEDPANFPISVRFSPPSVSTNEKIILSSMFHSLYTIAVQLSPAARSTGIEVMETTQFRLSCLQSRTGVKFVVVTSPSSSIPVDSLLNKIYELYADYALKNPFYAIDMPIRCSKFEECIKLLLERVDKNSNFVTINIINVIFTWYLCIGPLTLILFVPMSIDTNFPNRWQIPDLCGYLLFSDGAIIKSGGDLSNRENFMQIVEKIVNTVNSDILPNTKFYHITVSYPEHFYVISQSGKYTYVVKRKVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9G5</accession>
    <name>A0A0D8Y9G5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716151">
        <property type="protein sequence ID" value="KJH53488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9G5"/>
    <dbReference type="OrthoDB" id="5789694at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="362" mass="41355" checksum="F0E997F9A79046C4" modified="2015-05-27" version="1">MNGALREIRVGPDTFGAFRQVGLRNRHVQLRLRPAMFREHIAEANKCTFLLKVKDRQTEKELLKPEPYTVLPSANERAQGFKVPPTSSIGATLIQLYQTSTYAGRMCEITTTLFISPSQFRVTEWDLLPTSTPLQMDWRFRLLDDKSYHNFAVVCRDGQMFTSREALYFSSPFFREFFNGSGRQAEKMEFLDVAVEAAKTVIMFMVTSTFSAPASVSPSLVKDIYNLANRFDVMQLSGLMVGVERLGYLSVMEVIMAGVQLTIKECQELHNEEMSLLIDWFLTAHECHMNKLQNAAIAYLTRFHQRQYIAEYGDGEIPNPRPASERLNRGHGGFRTTPHVIQRVLNAQFSVCSVREVQRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y9K1</accession>
    <name>A0A0D8Y9K1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716188">
        <property type="protein sequence ID" value="KJH51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y9K1"/>
    <dbReference type="STRING" id="29172.A0A0D8Y9K1"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9309" checksum="4CD6CE8033F8DF1D" modified="2015-05-27" version="1">MSTKSLNQKKKCIEPHLHSTEANGCSTGVFSTLAIVNGNLGCEKKNEIYLATFQQLMGDQCCIVSWDNGQQIHLPKSAICRADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YA90</accession>
    <name>A0A0D8YA90_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaphanous GTPase-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_02329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716182">
        <property type="protein sequence ID" value="KJH51496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YA90"/>
    <dbReference type="STRING" id="29172.A0A0D8YA90"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="1">
        <location>
            <begin position="78"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="327" mass="37637" checksum="D92BEFAD64A86281" modified="2015-05-27" version="1">MICRKIWELEAFDYSHRTQHIFDWSIRISLLDFSFSSGFRMDFIEECMESVFACFNRRKAEEIENNPSNKSIYSFHSFELLDDGKLDKEFEIFVEECGLSEERQADLKSYSREKKLIMLNTHTFRPEEDCRKLITLLRTFEHESSDMVAPPTSLLQDLVITLRTQCSSFVEEFVSLEGVHLLSVLLLRCQLRPGYEPQSVCLLGAFRALLNSKSGRVAVLQDREALLVIARAIDLRDCKCKILAVEILSGLCFLPEDGHQQVLNALTQVSSVLGERTRFQTLINELHRKYHSAKETDRVRITILGLINALLRTGHAERKLTGQIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAB2</accession>
    <name>A0A0D8YAB2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAB2"/>
    <dbReference type="STRING" id="29172.A0A0D8YAB2"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="507" mass="58857" checksum="722A65097BCA41F3" modified="2015-05-27" version="1">MICRCCNLSPNQKIQVLRVAQIVLDYKLSLRRLKDSSEEYDIAIKQCHKRSASRLLELACANGGVFIKVGQHLSAMEYLIPSEYTTTLSILTSKAPEASYEDIVYVVESELKRKLDDVFSEFSVKPIGAASLAQVHIAKLKVVYIMIQRIYYFGLHTYTIQDINQKVAVKVQHRRVYKNSYTDMKTMDLLVRIADKVFPEFKLMWLVEEVRKNLPQELDFILEARNGDRLAKMFRHLEFLKVPKIYHAYSTPRLLTMEFCDGEHIDDIDYIMKNNIDRHDLCRKMGRLYSEMIFINGYLHADPHPGNVLVNKTASGEIKIVLLDHGLYLNIDDRFRSLYTDLWLALLAPDSAKLRRVATEMGVGDLYGLLACIVSRRTWKAVSQGIQNKKMDNHERSELRLYAASLIPQITELLHRMPRQMLLILKTNDLLRNLERVLGTESRSDSFIEMSKCVVRSHYELMMKDPQCGTLEAFGIRLKLLWALFKIQTYEWYLIVKQLFPVNCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAR4</accession>
    <name>A0A0D8YAR4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tropomodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_00578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716154">
        <property type="protein sequence ID" value="KJH53267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAR4"/>
    <dbReference type="STRING" id="29172.A0A0D8YAR4"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000099">
        <property type="entry name" value="Tropomodulin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH53267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="428" mass="48109" checksum="4071C94F2447218F" modified="2015-05-27" version="1">MSRTDYYAEEKTFTATSVVKPAKHPPISQAKLSGRGLKDLDDHDIDGLLSSLSIDELEDLNNDFDPDDNRNMIECGPNSVGKSIYGQSKMKVCPILNSMLPPSQRCRDQTDKTPTGPYKRDHLLKFLEDQAKSEKDWEDVVPFSPGIKRGKVWEGDNGQDFSEDGGEGTGASRAARMEMPIELDLDDEEDDLDRALDGAPERDLVDLAGILGMHNILNQPQYYNALKGKQQDDGMGSFSGVIRAYEPKEMPDEPDNETNVDDCIRRLEENEEDMTEVNINNMKRVSKEKIRKLISAACASKHITKLSMANTAISDSEARGLVELLETSPSLKVLNIESNFITPELLAKLLRSTLVTQTLTEFRAENQRQSVLGNQIEMDMMMSVEENETLLRVGVAFQSMEARHRVSEALEKNYERLRLRRLGKSMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YBY5</accession>
    <name>A0A0D8YBY5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_00126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YBY5"/>
    <dbReference type="STRING" id="29172.A0A0D8YBY5"/>
    <dbReference type="ESTHER" id="dicvi-a0a0d8yby5">
        <property type="family name" value="ABHD12-PHARC"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH53697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="314" mass="35411" checksum="3FB725792C7205C6" modified="2015-05-27" version="1">MDLDTLMLSIFIELGRMPLTDYMNVSANNVKSIGRAFYLQGQQGNIGVWHVLPKTLSSDYREKGVHPAEEEMEKSLSIMKFPVVLYLHGNSFDRAISHRVELYNVLSKMDYHVVAFDYRALPGYGDSDGCPSEPGLVNDAYLVYNYVKSHCGNNAVIIWGHSMGSGVGVKLTMDLSIEGRPSHGLVLESPFNNLHDVLLNHSLSLSIRWLPENIIQSLIILPLRKVGLVMESDKRIANVCCPILIMHAADDHVIPVKLARRLREAGRCSSRDVRYVEFDEARNYRHKFIYMAPELTKIIPDFVAHCKEVRGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YDY6</accession>
    <name>A0A0D8YDY6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716159">
        <property type="protein sequence ID" value="KJH52826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YDY6"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH52826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19450" checksum="4BE011FE0A9BE690" modified="2015-05-27" version="1">MLLLHCCFHYTNFVCITIIFEAGNRVCNILDDNLEETAVETTTDDVGFTEEIDFDELKRSPNTTYDIDDKNKSAELSPKLSALEVSNNVNDQKSDTGDVLLVATKISSESVVVPNESFVVACADKDFLNDNKVIDHVNKVGEQRFGTDQSSDAHDSVCVDSHIFLHFLSCGYKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7J1</accession>
    <name>A0A0D8X7J1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Receptor L domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_13538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717159">
        <property type="protein sequence ID" value="KJH40503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X7J1"/>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <begin position="7"/>
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    </evidence>
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    </evidence>
    <sequence length="76" mass="8391" checksum="7225588A40FCB27A" modified="2015-05-27" version="1">MTKTESRSTTPLSVTTTSGEKREEIDNPFDYGHPSDYFGKAVLASEVQVDELTMPPQSPSDDTKFDESSQYVGNNV</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716847">
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        </source>
    </evidence>
    <sequence length="100" mass="11318" checksum="9E182AAD7976C04F" modified="2015-05-27" version="1">MLVMSSLSNCHSVVDDIIDTGLTLSKLIHTLEQYGAKKVWTALLLSKRVPRKVTITEDFVAFNIPNKFIVGYGLDYNQKFRDLNHICVMSPAGIEKYKNT</sequence>
</entry>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="766" mass="87236" checksum="8901013FE4D9C050" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XA38</accession>
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        <submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN717162">
        <property type="protein sequence ID" value="KJH40499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000053766">
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    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335430" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15544" checksum="FDA220D754DE2F53" modified="2015-05-27" version="1">MVMKYYILLLLFDTLRTNRGDSKQDCSAFSTSNRHCTENSSHFITHEEKNSASVTIYDKRGNAVIKLNDKRDISINCLHDKDPVTTSGSYVIPKKDWNQQPIFWRRRKRDWRDKGYPAKMLTCKCTVNGTKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAY0</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716965">
        <property type="protein sequence ID" value="KJH40927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="18665" checksum="D635D801468C7146" modified="2015-05-27" version="1">MNTSYWLTIGDTAADAKWSRLGGSNRFCQVVSLLANHFGNQKAVIKQLIMMTCMDLFQNINPKTVVGVLCVYLENKNSRVREEVVNILTSALMITSSSRINFTAVLNLLVPLLIDPKRRVRLAAFEQLSVVGYLMSDKIDTLLKTVKNAEDRQSARGLSNAVMAQCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBU9</accession>
    <name>A0A0D8XBU9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_12886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716894">
        <property type="protein sequence ID" value="KJH41139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBU9"/>
    <dbReference type="STRING" id="29172.A0A0D8XBU9"/>
    <dbReference type="OrthoDB" id="5797993at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37962">
        <property type="entry name" value="MALE STERILE (3) 76CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37962:SF2">
        <property type="entry name" value="MALE STERILE (3) 76CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="197" mass="22617" checksum="9C1014654277C266" modified="2015-05-27" version="1">MYLEVDFCSVPGPLCIELPFYIRAVIKSPLLSQDSRLFFLLIAFERTVLIVFEHETETLTLFDSHMHGHSDGAVIATGHADNVADLCHWLSLNIFHESQLQHDRHREFEISLIRFCGTTSTPDCCTSTSILPSEFPFFAVARRRRKRRMDMKGTSKSFKLPKTRSNDCEDSEVLKTTVHQRNFIPLASLDNLRSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC30</accession>
    <name>A0A0D8XC30_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MTOR-associated protein MEAK7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBC/LysM-associated domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TLD domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_11851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716701">
        <property type="protein sequence ID" value="KJH42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC30"/>
    <dbReference type="STRING" id="29172.A0A0D8XC30"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF131">
        <property type="entry name" value="MTOR-ASSOCIATED PROTEIN MEAK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="10">
        <location>
            <begin position="139"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="368" mass="41336" checksum="4FCA9F76EEF09C23" modified="2015-05-27" version="1">MGGKISTSGKKDEFVNLCVEQIRRTEFELKKLSNGKEFLEYDEMMVGKLQPAVPLIYAILQHNHRCTISSILCLAENLLGDVILQRTALLRIFGTIPDALSNIVNIYSRRHELSTIESDALLEYLMFDAPRNDETQFDRWLLRNVVATQMILHVFSALVFQKAQFFSILHGSSFSQMARKVDGEGPCIVVVKSTNNKIFGCFASAGMNSMLSGVETTETHSYFLFKGFYMGSRYYGDATCFLFEIQPQIRIFSATGVAENYAYLNSQQNSLPNGLGIGGYKSTWPFFIHEEYGKGTTLANISSFEKCHLSGSDSFVISNIEVWRVGEKPSMPANNDCSLIEKSIIDKDVEARAMLEISGHKMQSDGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC64</accession>
    <name>A0A0D8XC64_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C4 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_14012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718079">
        <property type="protein sequence ID" value="KJH40071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XC64"/>
    <dbReference type="STRING" id="29172.A0A0D8XC64"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052496">
        <property type="entry name" value="Orphan_Nuclear_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47519:SF3">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH40071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="19955" checksum="6F2F27F39A035B80" modified="2015-05-27" version="1" fragment="single">MINSTCHSNCGEFDRKDAIVKLIDADEEDERIPCDGEICNVCGGDKVSFSIEEILQAAMHYGAIVCVGCKGFFRRALMKADQLECQLNSNCLIQFEVVEEDERIPCDGEICNVCGGDKAAMHYGAVVCVGCKGFFRRALMKADQLECQLNSNCLIQFGSRTHCRSCRFQRCREVGMKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCK0</accession>
    <name>A0A0D8XCK0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HDAg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716680">
        <property type="protein sequence ID" value="KJH42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCK0"/>
    <dbReference type="STRING" id="29172.A0A0D8XCK0"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037517">
        <property type="entry name" value="HDAG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51838">
        <property type="entry name" value="HDAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDAg" evidence="2">
        <location>
            <begin position="86"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="491" mass="55333" checksum="BAB0350FDB81AE24" modified="2015-05-27" version="1">MLKDMDLVNWLEKKLNDAGVWSGRITASMLTKEMLEELETCFQAIDMQTKLKIISCIPHMNPRKLSTVQSSLAVLLELAGKDADDWVETIADMYRDMPSATVIAPGCSNNDSHFAKTLEDMSKCFQKHLEQGNLQLSPEGHNIVSSSVNKASFGTSPEPYKLFILRKKPKSFNLMNDMMRQCTKLVEANREKNNGLWSSTVPIKMRSTLRSANNDLPMKGIPTQNPCKLNSGFTYEPKKFQRHLIKREGGAKLLGMNGDAKKAAAQQKQRKNSKRRDEKAKQEGVENASMSCGDDHASYMVTPEITEQHTFPHSVVDNEEPENTQTPYQRETRVAAIQGSSQMPENSYILRQTVHGIQNPPPQIHHQLDHNQPQHVQHFVAHHIQSSPMLSAYSGAPFKSTFQARDQQTPVQRAREIAIMKQCNEMLRDANSLDQNGRQIVIAFMTGNRCNPRPELGNVITMKLSETIEDGLADNKLVKMKVETFFQAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCL3</accession>
    <name>A0A0D8XCL3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_11678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716678">
        <property type="protein sequence ID" value="KJH42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCL3"/>
    <dbReference type="STRING" id="29172.A0A0D8XCL3"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904936">
        <property type="term" value="P:interneuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097475">
        <property type="term" value="P:motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031346">
        <property type="term" value="P:positive regulation of cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905485">
        <property type="term" value="P:positive regulation of motor neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040028">
        <property type="term" value="P:regulation of vulval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000005">
        <property type="entry name" value="Protein Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF116">
        <property type="entry name" value="ABNORMAL CELL LINEAGE PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="281" mass="31619" checksum="6B5A5B57916FEFE6" modified="2015-05-27" version="1">MHSKSFRSVQIACRTQPSTVIAAYEGIQDAMMECANRMRFQQWDCSNVGHIMHDPPILKYGYRESALIWALSSAGAAWGVATACAQGWIDDCSCVYEGQSGWEYGGCSYSVQHGITTSRKLLTKTPFVRSPLRSVEKHNLKAGRLAVKKTLIASCKCHGVSGSCQQKTCWKKTASLEHITDYLVDKYARSRMINGDQKIKNSDLVFIERSPDPCRQQTTSGRVCAWRNETHTQGDCSRLCCGKGFKVAHEVIQYKCDCKFVWCCKLICKDCLQHRWVSTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCV2</accession>
    <name>A0A0D8XCV2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_12421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="EMBL" id="KN716790">
        <property type="protein sequence ID" value="KJH41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XCV2"/>
    <dbReference type="STRING" id="29172.A0A0D8XCV2"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="352" mass="40220" checksum="AA1B7340ED60BD26" modified="2015-05-27" version="1">MSVKIRHPLITETKQSAIFGETLEIPNLKRVTFRRTPDCFHQSYDYVSVETMAITALPMDIWLKERLKKWVQLSGHEGSIVPATTSTLYKKQAGNCSEARAYENISKDSALNGFTPRYFKQLHKNDECFIEIEDLLQQFADPTKTSIMDIKIGTRTFLESEVSNMKQRKDLYEKMTAIDPEEPTPEERACGGITKLRYMQFRERESSSASMGFRIEAAKVAGGCLQKSFKKVRTIEDVTQTLIDFFGADRERVRSKLLARLRLMRSAIEKSRFFATHEVVGSSLLIVHDDEKVNCWMIDFAKSSPVEPPKSLNHRSPWVPGNSEDGYLTGIDNLIKILEEMPAVDSMKENSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XD85</accession>
    <name>A0A0D8XD85_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3 10">3.6.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_13666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'-&gt;5' exosome-mediated mRNA decay pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'-&gt;5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively. May also play a role in the 5'-&gt;3 mRNA decay pathway; m7GDP, the downstream product released by the 5'-&gt;3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17171"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74434"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3 10"/>
    <dbReference type="EMBL" id="KN717274">
        <property type="protein sequence ID" value="KJH40381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XD85"/>
    <dbReference type="STRING" id="29172.A0A0D8XD85"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000003">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH40381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="330" mass="37809" checksum="E6C5C8452B33E9BC" modified="2015-05-27" version="1">MRVHDGCESTTTKSDASHGDPVNLQENAAQLWLRSATFKEILGSDVSHKSLFVLLSNVKGEQGVFLLNKSAFSENADDINAILRSAELLEIMKNDIYGSYDAVIPSYLNMVKSQLIYPADEKIIAKYRQEEKFIINETAEDYRTITMEYIKNFQMDLKWVYNILSKESEADRIIFEDPDPYNGFILSPDIKWDGKSIENLYLLAMIHRKGVRSIRVIVAKISDLTADDLPLLENLRSHGLSAIREKYGVRPDQIRIYFHYQPSFYHLHVHFVCLKYDAPASTTLAAVLLDDVVNNLKMVPDYYKKATLSFTRKASDKLLQMFREAGRCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XDJ9</accession>
    <name>A0A0D8XDJ9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_12302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716772">
        <property type="protein sequence ID" value="KJH41719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XDJ9"/>
    <dbReference type="STRING" id="29172.A0A0D8XDJ9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="59"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="160" mass="17839" checksum="5F78ACBEDBBE8F68" modified="2015-05-27" version="1">MVLVRTLTGHTLNLDISPEDNVLSIKSKIAACEGIPIEDQRLILAGHQLSDDEQVEDFSTLHLALRLLGGAKKRKKKVYTTPKKIKHKRKKVKLAVLKYYEVDENGKIRRLRVECQSPSCGGGVFMAAHENRYYCGRCHDTLVVQEPVASSKAKGGKGKK</sequence>
</entry>
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    <accession>A0A0D8XDR6</accession>
    <name>A0A0D8XDR6_DICVI</name>
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        <submittedName>
            <fullName evidence="15">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_12234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KN716761">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000038">
        <property type="entry name" value="serine/threonine-protein kinase N2 isoform X1"/>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
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        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="REM-1" evidence="14">
        <location>
            <begin position="261"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="735"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH41789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119903" checksum="AFC8EEB2FA1C351D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEH0</accession>
    <name>A0A0D8XEH0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716603">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XEH0"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8950" checksum="AFF1DB8F15CB268C" modified="2015-05-27" version="1">MPVWCSSLDACLRSIFYARFMIRVLIRGISDNEGARIINTPFERSVDSARITNFCLSGELPRIQEMFFEERRQCSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEH3</accession>
    <name>A0A0D8XEH3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DM DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_13223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Rosa B.A."/>
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    </evidence>
    <sequence length="120" mass="13721" checksum="7CD81F1EE0E4BD1C" modified="2015-05-27" version="1">MLSPRLDIHCLQPRSDKKISIINCYSPTGAANKSKLNAFYNELGKVIRKEISFYKFVDVDFNARIETMKKKHYRIGKFGLGDRSENGGRLAALVSTLGLFHGNSFFVKKEHRPWTCELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XG88</accession>
    <name>A0A0D8XG88_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_12636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of actin nucleation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10266">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="275" mass="32106" checksum="96937FB28FCCCC8E" modified="2015-05-27" version="1">MENEAFLSKAKEEANAIMAEIVRLASFVPQEFINPNSSEFKPLIMGFDYFARAPYYEKLIEGREDLQDDFYNRNGDILSQFSTLFQTLATFLCSLKEYIDQVANERIGRSYLDVVDMEILFHIGLVLLYFEKFLPSAVAERIYVAVYRNRRLKINESFVDKCLSCCENIYKEGVNDFVKLHVDKNLLSKWMFVFLLFKPAIMKTEAVKMRKIVEDFFRDDWVLQLGLGLNVNLIEKWQHYRAALTAITSKVDVKKAKQLALDHYNTLEKLTIPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XGW2</accession>
    <name>A0A0D8XGW2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_12426</name>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716791">
        <property type="protein sequence ID" value="KJH41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XGW2"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="60" mass="6896" checksum="13596ACDAD135CE5" modified="2015-05-27" version="1">MSQQREEKMEIKQLILNLAAPGCCRRNKLIIECNHDGDNDNDNDNDNDNDNDDDDDDEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHJ7</accession>
    <name>A0A0D8XHJ7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">DICVIV_09873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716500">
        <property type="protein sequence ID" value="KJH44093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHJ7"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
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        <location>
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            <end position="104"/>
        </location>
    </feature>
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            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH44093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="221" mass="25136" checksum="F20A507E0E0F5324" modified="2015-05-27" version="1">MGPKSEAKITQPNRESAGKRKRRTGRKKSKEGRRDSSMFCCSRKKSSAKKMSSKKHRGKMKGTHFGRSKNALKHRGRKSKSKELRKGKSGSRSKIKNRIRSRKDSRKESRKDSRSKSRSKSRSVTASRRRSKTRMKGKPGTHERNLLENRQHLFKSQSLSASQPPSEKSLPKASSIDSSSRRNVEQGAVQTPYSPKNTASSLICYASVYSVIYILHMWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJD0</accession>
    <name>A0A0D8XJD0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNARE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_10104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716519">
        <property type="protein sequence ID" value="KJH43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XJD0"/>
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    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH44372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="226" mass="25646" checksum="D043166DC851E272" modified="2015-05-27" version="1">MVHTDSSSESRSSRSGYFSEASASCREKNDEEIAVNGMVDSHNVNVKHIKSLLSPGKHTHTPLIQASIPKETAIATHAALSGLSPEKERRWQLRELYDRLDIDNDGSVDIRDLTAALKHEMPHIPSRLAPAKHEKRLEVIFQDLDKNNDGHIDVREIKSFCNELGIALDDTRAKDILKSSKNTISWTLLESIGNYQPCRFKIYTFIIRLTQNLHDDYCIVYISHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLA4</accession>
    <name>A0A0D8XLA4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_09439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716465">
        <property type="protein sequence ID" value="KJH44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLA4"/>
    <dbReference type="OrthoDB" id="5869822at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="161" mass="18275" checksum="7F77305961F4D5E5" modified="2015-05-27" version="1">MLDHTVRQLNMTSCFCSSDCGRNKKKIGIVIVPAISINSLISCESSLDFAQPISLPAAAYLFAQLLNRHWSTQCKADLMIIYVRSWNPDRIRKPLVVPIYSNSLERLQRYGHPTSVSFREPVLAALQSAIQRAHRLIEAEWITPFRSIHQFLIGRSHCLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLN3</accession>
    <name>A0A0D8XLN3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716401">
        <property type="protein sequence ID" value="KJH45553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLN3"/>
    <dbReference type="STRING" id="29172.A0A0D8XLN3"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14807" checksum="0F55EE1C9D379780" modified="2015-05-27" version="1">MPTGSLNANQNLFHLRRIPPNKCRSDPSRGVEATLILLDTFTKFGRNPEKCDVVLTSSVFSSSNMISRDHADIIGVKGASGRIEKYHINDRSLNGTYINDQRKPTFGVWQKNCKHIFYLFPWLYFLKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLP0</accession>
    <name>A0A0D8XLP0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DICVIV_09296</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="EMBL" id="KN716456">
        <property type="protein sequence ID" value="KJH44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLP0"/>
    <dbReference type="STRING" id="29172.A0A0D8XLP0"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="16">
        <location>
            <begin position="150"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="687"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="404"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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    <sequence length="70" mass="7741" checksum="2F2EECF34655B722" modified="2015-05-27" version="1">MPVSERSTVFTSSKNKTEIVLIKLFWPSIVFLNLKLPITIGSFILKAQAPANLAKFSSEHVPGDDDPIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="2">Cytoplasm</location>
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        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
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        <property type="protein sequence ID" value="KJH45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="133" mass="15363" checksum="B4E21A7C7378B232" modified="2015-05-27" version="1">MRASSTSSTDSNGFPVKDPDALKLFVAHTYNTTSYKFNLINMLNVNVHRFFVLFQIPRNLEEKDLRHLFEQFGKIYEFTILKDKYTGMHKGCAFLTYCHRDSAMKCQAALHDQKTLPGVSYKRKARNNSSPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMX2</accession>
    <name>A0A0D8XMX2_DICVI</name>
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        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_07946</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716375">
        <property type="protein sequence ID" value="KJH45988.1"/>
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        <location>
            <begin position="445"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="566" mass="65463" checksum="A92BA1775A2E2721" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN50</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="84" mass="9167" checksum="A872EA9730D58681" modified="2015-05-27" version="1">MPPTIVSDSMRDVVALVGQDVDFTCKVDSLGRHMIAFVRSSTPPSLISFDEKESDRGNYSCQVNANPLLSATGKLDVKAVFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN63</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716525">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
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        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="23566" checksum="344B8D7204B0B288" modified="2015-05-27" version="1">MEQLDKFIFQENKIVTPEFLCEHAQVSLVEAKSFMEIFYEVHKGTNGLWATFMAFGTIARSGVRIETTVVFRDADMERVKEEFEEIIKMELLSLQVVEIHNRSPNHPREEGEEIDEQNSTENRSTNDGDSISSGDILPPNDSPEWSSSTTPEDDASDNERPKSSYSWGIVSPDNSEVDSRSPPPSGTPEHVSPIQNFLDCEFIFFPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XN70</accession>
    <name>A0A0D8XN70_DICVI</name>
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        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_07835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716369">
        <property type="protein sequence ID" value="KJH46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XN70"/>
    <dbReference type="STRING" id="29172.A0A0D8XN70"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0969">Cilium</keyword>
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    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="178"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="8">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJH46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="391" mass="43946" checksum="3AFFCBCCF3E477FC" modified="2015-05-27" version="1">MERYKHCVYDLAFKPDGSELLVAADNKVIIYDGTDGTLLQDLVYAVAWSHDGTTFASGSADRSVILWTEQHEGTLKYSHSEAIQCLAFSPTSSLLLSCAIGDFGMWSADEKNVHKQRINGRCCSCAWNRDGNVFAIGTFDGFVHIKNIGNFQKDEYVAKIERPGGDPVWALRFCSSRPQDETLSQFHDNESTTEVLVVADWSRRVGFYDSEGNSIKRDDLLLNYDPTCVEYIASGRFLLIGGSGRQVTLHTKLGTEIGTVAQMDTWVWCVRVRPVSNPSTVVVGCVDGTIACYNLMFSTIHGLHKDRYAFRDNMTDVVVQHLVHHTMTRIPCHDLVKKVAIYGHKLAVQLSDRVHIYRQVKRDDEDKQLEYSLSERINKAFDCSLLVSCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNL9</accession>
    <name>A0A0D8XNL9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716413">
        <property type="protein sequence ID" value="KJH45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNL9"/>
    <dbReference type="OrthoDB" id="5867030at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="331" mass="37139" checksum="8C237D4F355D91A0" modified="2015-05-27" version="1">MRDARNSPPKQDVFYFFILNVCSGFMLSAAHNVLYFVLDIKTPVIHFLHHFFTFLFMLLLYQLGCIPKGPLSLTEFKAPVVAKFCETILSSLVHSQNRQGELYLVRVFDFIFTFTILVLGKHLVPSREYGKLEAKLMVPLALSSSLSWLEMNQIEFTPLSLFCAPLLATARAVSLLTMQRAYSQYGEGVSAVHPEQFCLYYTGLTSAVLLLPALYSYSTSHVEVDASWESIDYTLMSLSCLFMSFNLYSDLWLGLSLSARAYAALDSTKYLGASINVEQCSCIDLVDQIVLIHLSSKVGQWIIQNMAHPNVIAFGGKILTVVCLSRLITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNN7</accession>
    <name>A0A0D8XNN7_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_07771</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KN716366">
        <property type="protein sequence ID" value="KJH46165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XNN7"/>
    <dbReference type="STRING" id="29172.A0A0D8XNN7"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
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    <dbReference type="SMART" id="SM00175">
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    </dbReference>
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        <property type="entry name" value="RAN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
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            <begin position="193"/>
            <end position="208"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH46165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="22831" checksum="805A0BBFF3B6BC82" modified="2015-05-27" version="1">MAYRTATAPRTGSANKTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDEATVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFQKAKTWVKELQKQASPNIVIALAGNKADMANRRTVEHDEAKAYAEDNALLFVETSAKTSMNVNEVFLSIAKKLPIGPPTGEPSGTVDMNQPQQAQKGNCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XNP7</accession>
    <name>A0A0D8XNP7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_08575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716411">
        <property type="protein sequence ID" value="KJH45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="175" mass="20207" checksum="6061DB5DD2178569" modified="2015-05-27" version="1">MSNKEFFVPSEEVMTTIVLPTIIFCIGMVVAMLVGINKCKQWELDKIVEMRRTRRVLQRITARLREKNFKTIQNARNLRKRVAASKAVEKTVKTQVSPPIYSTQQQAVCGQSPPPSYEDTLLDEYYYECLPSNSRSHSVVTINNRRSSTQSRISRRTRRTSRRTSKRKTHGITAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XPY5</accession>
    <name>A0A0D8XPY5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_08156</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KN716386">
        <property type="protein sequence ID" value="KJH45802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XPY5"/>
    <dbReference type="STRING" id="29172.A0A0D8XPY5"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH45802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="410" mass="46965" checksum="112176BA2F21B1EE" modified="2015-05-27" version="1">MELWPFIDYATTTSITEALKRSVYDAIVQLSEVVSEKFLKTLLPFLHCTAWDEVVEERFLGNPRLCGFPTCNEVIIRREKKQRFHIDREARKIYENRMVRDMYCSRLCMLRSSSIRAQLADEPLWISGNIKKRISLPYITDATMVVNNMTSENVGIEIVNVVEEKLSDLRIRETEVSTSSDSEDDEECLTDVDSVHDLLDGNIDDKKDFNNERNQKLGADTDLSGGDSDKKMMKNSTKISCSSTFSIDKESVNKSGTLVNNQRLPDPQMSSNCSLTEAELEKLARLRSKYSGYAVKKPVVIEPRHCLRKQHGKESNVDAIVDCSDTQKTVELVWNLFRSDTVFMKFNSIGWITERTYHVLRYGSSHVSVSSFAIMDVSRESEIDHVCSDEIFLPTVDSLDVRKKRLLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR35</accession>
    <name>A0A0D8XR35_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_09168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716447">
        <property type="protein sequence ID" value="KJH44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR35"/>
    <dbReference type="STRING" id="29172.A0A0D8XR35"/>
    <dbReference type="OrthoDB" id="5781608at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="DAN" evidence="6">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="108" mass="12281" checksum="478CE1A8027010C4" modified="2015-05-27" version="1">MDASNTLQHMFNYCMLSYRPILFIAMILLISSHHVISIAPKYHCRKVGAEEIIDERGCELVILRVNRCSGHCLSITFPNPITGRISVHAKCCRMTDTEWVISVPVLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR64</accession>
    <name>A0A0D8XR64_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WH1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_06935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ena/VASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716325">
        <property type="protein sequence ID" value="KJH47005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR64"/>
    <dbReference type="STRING" id="29172.A0A0D8XR64"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF22">
        <property type="entry name" value="PROTEIN ENABLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH47005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="540" mass="59393" checksum="266A8740E742DFEE" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR65</accession>
    <name>A0A0D8XR65_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_06746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR65"/>
    <dbReference type="STRING" id="29172.A0A0D8XR65"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000165">
        <property type="entry name" value="Tubulointerstitial nephritis antigen-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018786829" evidence="3">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="4">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH47158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="482" mass="55776" checksum="5D8142D8944C731C" modified="2015-05-27" version="1">MRLLLQLLVAYICVDQFLSRGFHGIPGRYCSVRTPTCCPNRDDECTAAIQRDHLCYCDMFCDRSPHGGRYCSVRTPTCCPNRDDECTAAIQRDHLCYCDMFCDRSPHGGNDCCPDFEATCRGRGKHESDECISDGIRYNEGDSIEQNCRSWWSARNYSFFWGRSLDEGLKYRLGTLFPEQSVQNMNEIVIKPRDLPEEFDVREKYVCRFYRLNESLKTITILRWPGLIHEVRDQGDCGSSWAVSTTTISSDRLSIISDGRINATISPQQLLSCNQHRQRGCEGGYLDRAWWYIRKLGVVDEECYPYESGQTREPGECRIPKRSYKDGNKITCPSGSELDSTVYKMTPPYRVSSREEDIMTEMITNGPVQATFLVHEDFFMYSSGVYRHTELAKKKGESFTGRGYHAVRLLGWGVDHSTGRDIPYWLAANSWGREWGEDGLFRILRGVDHCQIESFVISAWGRGSKRRRHFKMRKMRRRFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XR97</accession>
    <name>A0A0D8XR97_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_07637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716360">
        <property type="protein sequence ID" value="KJH46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XR97"/>
    <dbReference type="STRING" id="29172.A0A0D8XR97"/>
    <dbReference type="OrthoDB" id="5863934at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35547" checksum="42EBAD2948D88EC6" modified="2015-05-27" version="1">MTSQKKRIRLWNEEEKVIEACAATILYRKRRNASILPIPSSLNDLIKQNQLLRLENMMMQLLPEPKFRSGNCSEESCSVGEDFGELIYNPVRDGTKCRYRLCRDISFGKEVFPVQVYSDTHNCVPPEDFIYISSNDYSKFKSDCPFIDDSLFTVNCCCSDLICAESCFCRKMNDKLTPCTIMGDGRVFLNSNATFFNTLIVGCGEKCSCRAKCKNTLSGVCLPAPFNHLPPCDERKDDYVVPNVHRSEIRHAISSIRNRTAPGPDRIRPEHLKNLPQVLIETLARLFTRYLSEYKVPSQWKTSRNVLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS26</accession>
    <name>A0A0D8XS26_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_06474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716307">
        <property type="protein sequence ID" value="KJH47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS26"/>
    <dbReference type="STRING" id="29172.A0A0D8XS26"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43618" checksum="CAB5AF99F56521CA" modified="2015-05-27" version="1">MIALNVYMAMCYYKMDYFDVAQEVLNVYLRSFPDSPVALNLRACITFKIYNGKAALPEVETLQRVNLYPAARELLRHNQVLFFNCYIREGDGALQILPGLMDTLPEARVNLILYHLKREDIDSAMTLCNELEPQTTTEFLVKAVTFAYWGQMKESKDHLKTAEQFFKMVGESPYDTAIWNIVRKFTFQISSKTVRIDTIPGRQSMACSLFLSGQFDDALIYLNSIQTEMQCGLWKEAEGHFLAIAGAIRDKPTYKYMLAKAYIMNHKPQLAWEMYTRSNDPKESFNILRIIAMDCYTVREFYYAAKAFDGLEKIDPSPENWQGKRGAISGLFKAFVQGEASNEQMSEILQLLDRGNHPQADFVSSTIRKWANSHNIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XS34</accession>
    <name>A0A0D8XS34_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716345">
        <property type="protein sequence ID" value="KJH46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS34"/>
    <dbReference type="STRING" id="29172.A0A0D8XS34"/>
    <dbReference type="OrthoDB" id="10065820at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031937">
        <property type="entry name" value="PNISR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31518">
        <property type="entry name" value="ARGININE/SERINE-RICH PROTEIN PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15996">
        <property type="entry name" value="PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="606" mass="66059" checksum="5FC05FC2D79C07BB" modified="2015-05-27" version="1"> </sequence>
</entry>
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    <accession>A0A0D8XSI8</accession>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:steroid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
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    </dbReference>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33478" checksum="EA698801E0306EE2" modified="2015-05-27" version="1">MSSHFHFEECLRPIALSTLNAHLHGIVNNAGVFTIFGPDDWCSTEEYMASLNVNTLGAVRVCHNFVPLIKKCKGRVVTMGSTAGRLHGLYVGPYVTAKFAVEAYMDCLRLEMRPFEVSVHILEPGAFKTELLSEEALHARVNKIWEKLSLTTKNEYGEQFKENFKIAWQTGVNIVANTNLQWVVDSYVHALFACWPRMRYAAGWDAIFCFIPLSLLPTWIQDSVLHFMYSMQPGPPLHPASLHNDEKPTTSRTFSSLFGKAGHFSILSIVFVAFYIRSFFLYATARVTPVNATVSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTG1</accession>
    <name>A0A0D8XTG1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716293">
        <property type="protein sequence ID" value="KJH47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XTG1"/>
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    <dbReference type="Proteomes" id="UP000053766">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SHSP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="111" mass="12618" checksum="1642A3EA6392EBAE" modified="2015-05-27" version="1">MSTIEVTHEAKLWDWPLQSNEGVVKVINTDDKFEVGLDAQFFTPKEIEVKICGQEILIHCRHESRPDEHGSVSREVHRAYKLPADVDVSTLKSNLTSRGVLLISAKKQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTH2</accession>
    <name>A0A0D8XTH2_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_05980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716288">
        <property type="protein sequence ID" value="KJH47913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTH2"/>
    <dbReference type="OrthoDB" id="5805917at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH47913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="78" mass="9270" checksum="41723241D7FDA21E" modified="2015-05-27" version="1">MTDDISIDKRMRQFAFAKRSPYRQFAFAKRMDDVDEDSVEKRARFAFAKRSPYRQFAFAKRSSPYGFAFAKRDYASFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTQ1</accession>
    <name>A0A0D8XTQ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_06742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716318">
        <property type="protein sequence ID" value="KJH47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XTQ1"/>
    <dbReference type="STRING" id="29172.A0A0D8XTQ1"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7352" checksum="029895F2F51EA1DF" modified="2015-05-27" version="1">MRKNTMLYCITIMLVVLSTESLPFLCDDNGEACQLHCLETMHSLVWNCVYHTCVCHDRIEPYL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
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            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="208" mass="22888" checksum="9D019B34129FB6DD" modified="2015-05-27" version="1">MAATNVVEKRFLFEAPPPYEETDGSSLTTVSDLRRMVFVKLPDLLIQDMDVQRTSAILHANSTISATFSSACGSKPCGETNFNAITTSSTQPSSEGLSNSAAITLSQPTTICKATNTRLQSTKAINDGYKQAYDSARNIISKRKRVDAKTFTDHSLKNTGKDEFSTTSSYACEEIRLDNCAMKEKERAEEMSQCSRIPHHKSSPTDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002335991" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8260" checksum="1BC5568F8CE7A783" modified="2015-05-27" version="1">MFLRISIMQCHLFRRLLFISTILLIDPSYCQTPVIGGRCSLGTPDVQIGGKQTQFFLRCDAMSEYVAIDFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XVY1</accession>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH46516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19824" checksum="900283BF3CCEDF2F" modified="2015-05-27" version="1">MWNAMEIVEFSLSATLCTSQFVGSILKLLTPLTDSKYSAEEIRSFDDFMCVFWFIALLGCLTKQRDIAVFTTMGLIYSFIQAVRWATIAHYNYLNHLVLTCTREQQHRNPSMCETYDVIFLILCSITVFFTAIASMLSITQLWSDRLPSTDHANNSENLGKNAIISAFNYPIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="12 13">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716246">
        <property type="protein sequence ID" value="KJH49083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KIX_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="Med15_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="186"/>
        </location>
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            <end position="104"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH49083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="198" mass="21942" checksum="41BF2A9E6DD160F0" modified="2015-05-27" version="1">MADDDWPSQRFREHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNGSNTNSTTSYRASVPPDPQPTQTRNQSQSLSSSAAQQQIPQQQQQANVLVGHQQPAFIPPEQQRGPPHYATPPLGQPPPQMQPSNAQTMQQQQVKNIFSSFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XWU3</accession>
    <name>A0A0D8XWU3_DICVI</name>
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        </alternativeName>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L23"/>
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    </dbReference>
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        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L14"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
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            <begin position="19"/>
            <end position="176"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="176" mass="19196" checksum="1617F3BB3E3BAC7F" modified="2015-05-27" version="1">MQDGFLFILLALHKSFLAFFSSSKRIWKHVLFRIGRMSKRGRGGASGAKFRISLGLPVGAVINCADNTGAKNLFVIAVYGIRGRLNRLPSAGVGDMFVASVKKGKPELRKKVLQAVVIRQRKQFRRKDGTFIYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIAANAGSIA</sequence>
</entry>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="24"/>
            <end position="54"/>
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            <begin position="26"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJH48519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="106" mass="11890" checksum="F2AB59F8AA5382C8" modified="2015-05-27" version="1">MVTVELTVQLVVQIELEPPNTIAAQKKKDAKDNKLSAKIQQKSTKRKNQGILPPNSIDKSFIKFDTPFYFMVIRQGAFGRIVHSVGRFNSDGMDQFGMNFDGVSNV</sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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            <end position="114"/>
        </location>
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        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22772" checksum="A29AF9C4040F29BA" modified="2015-05-27" version="1">MVLDIPELSAERDRDQHSLRSRCVSDTNIASEDVESFDVRGRALPQQYRDLVRELSDYLLDSAFLDCVFDVHREASILHRHGLRIDSPPSTPSHDSPQSCSDTPRLRPPESNTPITVKCRVCGRMVGAKVFEKHIISCRKLDGSRSSSRAAAKKIAEQEMIAESTFNDDDFISPIPVPGSSGDDEEWNAPRKRRRTRRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYU1</accession>
    <name>A0A0D8XYU1_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716248">
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_4"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH49017.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="361" mass="41375" checksum="826D5DCB8D777419" modified="2015-05-27" version="1">MVADIGNTIDFLHRVRALKVRGAKGYVGTSNILWNSLSFSLHFCKNLLALWISDSDVSKVHGLGSIRRTLRRLVVHYSMSDIKDLLLEGEPILPISEMEHWACLEEVDFSFNDLKNIDESIQLLGGVQKLNISHNNVTDIGNYLQLLTSLTELDLSSNGISSVNQWNELLGNLKKLILSNNVIKDVTGLHRLYSLEYLDLRNNAIETVESVSALGGLPCLEILHLSENSVAKVVDYRTKVLECFGERHWECLNETQEFIIVICALKLNNPVYYGQMTVKVFNQFDHFEHFGVLFVQFCSRVKLDGEAPDDRERDTIKLRMALRRAKKEKEEKERKRRQKIEEKIRYISGNVCEYNDEVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZ01</accession>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716249">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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        </source>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="192" mass="21414" checksum="1B3AF2FC1B40A48A" modified="2015-05-27" version="1">MSICRAYHRPIAPTYEEVLAFQKQVAIMWDSDQPSTSKQAIEIGGHNSAIQMVENEPLFTDSYDGIEEFCGESGIDSPEPGELVDGGVITFNSERKDKDEIEEGEYMEWNSDNNYHPAQSLIKANDDESDVFDRIDSSNTGESDAISLTESPLSNDHLSFPIFNDQLLESPTRIDYFGKSDKVSTLHSGYAT</sequence>
</entry>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">HannoverDv2000</strain>
        </source>
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            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
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    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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            <end position="339"/>
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        <ligand>
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            <position position="436"/>
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        <ligand>
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            <end position="461"/>
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        <ligand>
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        <location>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH49407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
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                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KJH48041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26228" checksum="138058007194425C" modified="2015-05-27" version="1">MNPAKSSNVIPYLSDVITAMRMTQPTDSSEVYEFLTWPQIVGRNVGAYSHKSLRNFLLKPNGNLVINPYHIRLRTLNASTIQPWASLMCTAMINNEPRSLGVIVNVDYLVNEKRRFKYSDIKTLDAEKTKPLQGKESLPVLDHRANLKIKPWNEKSINNEFQKIMSISPYKEKGIAFFSTIWETADFLLEAKEYKIGGGEKETYLRGIKHSMLHCRCGSDAVHETGSRHP</sequence>
</entry>
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    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="395"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
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            <end position="606"/>
        </location>
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        <location>
            <begin position="607"/>
            <end position="722"/>
        </location>
    </feature>
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            <begin position="720"/>
            <end position="794"/>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="900" mass="101272" checksum="05930724E40BB190" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716223">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Putative prenylated protein tyrosine phosphatase"/>
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    </dbReference>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
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            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH49794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="189" mass="21329" checksum="4359D4F9A4BD2CBB" modified="2015-05-27" version="1">MGTSTTQKKITVTNAGAYFKPAPSEILYGRMRFLITDRPSDSSINSFIEELDKHSARAVVRVCEPTYATKPLRDHGIDVLDWEFSDGSPPPPEVIRDWLKLVRASFRDHPEQCIAVHCVAGLGRAPVLVAIALIEAGMKYEDAVELIRRQRRGALNQKQLNFLEKYKPTGELRKLRYSVDGKQKSCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y1A1</accession>
    <name>A0A0D8Y1A1_DICVI</name>
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        <recommendedName>
            <fullName evidence="13">Heme transporter hrg-1</fullName>
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    <gene>
        <name evidence="11" type="ORF">DICVIV_04067</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="11 12" key="1">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716223">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH49814.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17137" checksum="B7143A450348395B" modified="2015-05-27" version="1">MCNTKVRIAIAILGISAGLMAGCCFAVQYQNWPATTMAFLSAVAASVVLYVHLAYSNGWIHDWSRAQFKYFIWGGWTFFVVGMIGMICSLINAGVKHQTLTANGLKGGNFWITAVWFFMLAKWTSLIAIYTRQYMDIITIPLSKSPPIPVEQTI</sequence>
</entry>
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    <accession>A0A0D8Y1M5</accession>
    <name>A0A0D8Y1M5_DICVI</name>
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        <submittedName>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716219">
        <property type="protein sequence ID" value="KJH49949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y1M5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336137" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="62" mass="7653" checksum="553D66B84EF33CDA" modified="2015-05-27" version="1">MKFRMRSFFVNIIWFYLLFFRNSLKNSTCRSLKHQPSHRKMLNRHLLNSLEALKPYLLHILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y226</accession>
    <name>A0A0D8Y226_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_03081</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="EMBL" id="KN716198">
        <property type="protein sequence ID" value="KJH50735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y226"/>
    <dbReference type="STRING" id="29172.A0A0D8Y226"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16744">
        <property type="entry name" value="RING-HC_RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH50735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="200" mass="22382" checksum="A37C5272831E67C3" modified="2015-05-27" version="1">MNRGEEAVHEMNGNVKSNPSSPILPSAEKPETSKKEDDSTRFECNICLDTAKDAVVSMCGHLFCWPCLVQWLDTRPNRQLCPVCKAAISKEKVIPLYGRGGENTDPREKLPPRPRGQRTEATQQGFPGFQWGEGGPGGGVQFSLGIGVFPLSFFTTWFTAPQDPRPAAPHRGSRQYQEEQFLSNMFLYLGVFFVLWLIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2H5</accession>
    <name>A0A0D8Y2H5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716208">
        <property type="protein sequence ID" value="KJH50367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2H5"/>
    <dbReference type="OrthoDB" id="5808995at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="296" mass="34644" checksum="ED1B308B0ACDAF12" modified="2015-05-27" version="1">MLNELPSHIRLRIYQLIEPKDLKVLRTVQRCDYEFVINNRNFLRKTPVLLRVRAEEQKFIIDIYKAEFSHDKPRKFIIISTDLDEFYRFKELAVKGLILECAPDGDITLLFRAVCLLPIDIECSLTFKSLCFTDDDISQVLTMLTRIRSIPLLKLKECVFPAESVAHFFLNSHVTSRSFRIEDEQCFTKGNERASNRIGDELLRIFLSSDCDAISLSTVEEVSFRGLTNFIQSWRRNPRQFSLATFIRSERFNSESHFDLLPTTIYPLSKSDLVLRAQTDNLHQVRLITERLVRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2P2</accession>
    <name>A0A0D8Y2P2_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DICVIV_03448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="KN716206">
        <property type="protein sequence ID" value="KJH50437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2P2"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2P2"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJH50437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="314" mass="35192" checksum="A722B6C2FEC9B3C2" modified="2015-05-27" version="1">MLGTTDAWQFRSEQVDRLGSLLNDTRLPLKSRFRALFNLRNIGCNLSVKWISKCLQDNSTLLKHELAYCLGQMQNKSAVPILIDLLKDHRQEPIVRHEAGEALGAIGDEAAKNVLQEYAKDSCPEIAETCELALQRLTWIKENDDKTESPYRSIDPTCTASEDDVNVLRCILTDDSKSLWDRYRAMFKLRNIKTDASVKALSQGLYCEDSALLRHEVAYVLGQVQSPIAIDALKSRLSLSSENSMVRHECAEALGAIATTECITILQNYIDDVEASNCVIATTCYQIVRESCEVALDMAEYENSGELNYAVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2W4</accession>
    <name>A0A0D8Y2W4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_04945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716251">
        <property type="protein sequence ID" value="KJH48916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y2W4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y2W4"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF193">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH48916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="211" mass="23867" checksum="FD76DA9FBC6A1B67" modified="2015-05-27" version="1">MNISIHSLIDRQRSDVTMHSIIVSDSTISPETVKKQQGNIVTSRRKGISAHLTLINLLKGMIGPGCFSLPLAFRQSGLWAGFVLVFIIGFLTCISMLKIVRCSQFLTSRNPDVKSLDYAETADESFKQSFKQLRSYGCIFRRFVNLCLSSLVLGVCTIYYIFVVDHAKEVLIYIWPGLQMSKFSYLSIAIIPFMMLSFVRHLPLESNERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="120" mass="13251" checksum="D3D1B44D2FB5B8C0" modified="2015-05-27" version="1">MAMIDYSSTPFHRQILEKSFEYGDTVALANHNGSLYPTLTNPQLSMVHTDSNGDVSYHDIYKLSHRFADFLHSIGLSKGDSILVLLPNSSWYAIVFLGAALIGCPLSGISHEATFGRIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3Y0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">DICVIV_03134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716199">
        <property type="protein sequence ID" value="KJH50694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3Y0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3Y0"/>
    <dbReference type="OrthoDB" id="5857697at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Nematodes_ZYG-11_interact"/>
    </dbReference>
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        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31176:SF1">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05884">
        <property type="entry name" value="ZYG-11_interact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
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            <end position="140"/>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="366" mass="39789" checksum="9F386FC8134CBD88" modified="2015-05-27" version="1">MQPQAVFQGVLLFYLLYDKVMDSVVEVVQAYRHELEETMQSLRQRGEALGQSAPKLIEDTKSQIEPKTQQLFAAVQDTSAVSPAPKPVVEIFAWATVMILFANIGILIGSYILGPILSAILGKTGAAILAFIVVPSYAHISITEVCYIHVLIDIIMNSPFVMTLSITIDHDIIMMRVRLLIWSYMVKCYCAVRATPDGYTSICQCVVNRRHGLTTHFKKSGGDDAAVRFEVLSLAIAQGILMGFVIDSLYLSAIPFAILTPAIITASFPVVTQAAGGNRVTILAGTIGASVIINLAIGLIIGSLSFTYFLLTLTYGSIAAVIMQLIFRNLQEGAKGHVYQNALSCGFVIAKGMFFLLFGSSEPETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y400</accession>
    <name>A0A0D8Y400_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter, major facilitator family protein</fullName>
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        <name evidence="2" type="ORF">DICVIV_04612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716240">
        <property type="protein sequence ID" value="KJH49286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8Y400"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757:SF15">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45757">
        <property type="entry name" value="PROTEIN CBG23364-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <end position="31"/>
        </location>
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            <begin position="52"/>
            <end position="73"/>
        </location>
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        <location>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39327" checksum="9407CE7652AA0757" modified="2015-05-27" version="1">MNGFRYIILLVSTLFMTFIYSNRIVFGFSIICEITENITNSEYFLSDSSIRAWMFTVTAIGMCLGPIPLYWAHTVDTRVLILAYGLLSTVATALYPFADGCGLWPSLLARFLSVIYYTLGFLTLLFTLMFTFIYLDNVYKNRVVSQKEIQKIIEGRKIVSEKVSVPYIDLLGDVSIWINFILFIGYYIGMIVYQQYSPMFIKQILKYSVRETGYFSAIPMVFAIILKITVGRLIDHGLGLDAKWRLATPLVFLEFVSSLSIFLTGFIGAQHAHFALNFNMFIAGFVQILIPGGVQLLVSDNTREQWSILFYTITAITLATTILYVTFVEVKAATWTEPKANQLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y451</accession>
    <name>A0A0D8Y451_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HIT zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_02194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716179">
        <property type="protein sequence ID" value="KJH51658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y451"/>
    <dbReference type="STRING" id="29172.A0A0D8Y451"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH51658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20828" checksum="91B8ACF1486659AE" modified="2015-05-27" version="1">MFRRPVVRTTKLRHSARFAAKEAARVLDGAERSSLTNHKLAKLEQDNAHEDPHANIVWRKDLPNFEDEMIGGPKKKGSRKRSCATPGQGQPKRRRKFRARRFRNFISALDEADQKYRNNNRIYRAFFKATAPAPKIRGRKFCAPCGDWGIYTCTRCGTPYCSITCRDIHMDTKCERWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4J8</accession>
    <name>A0A0D8Y4J8_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_02676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716190">
        <property type="protein sequence ID" value="KJH51117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4J8"/>
    <dbReference type="OrthoDB" id="5801246at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="279" mass="32452" checksum="14873F9D92EC3D76" modified="2015-05-27" version="1" fragment="single">NSYYLDGLEQCNNIDREWTDHVQDEALRYGNVENAVWLQKAGMKQFTALFMTLPPYHMDRISSAACAKHEKQLTCGAEYEGIETTERRVADLKKIGNHRMMFEKECKDSGFVTRVYPCVGQDVNKWIQPCAENVDVYSAIRDSVSQRISSKYEKAVKKVKQSDRDSYKDDMETFENTMTSIALLEGSKCGLFKQMRVCVLRQLLETCGVEAMKAFNMSISLGYLRTERRERLNLDFEVRFQLSHSSELYWFMKAIEMFNGFINGFLEFNDEICMDSEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4K9</accession>
    <name>A0A0D8Y4K9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_04381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4K9"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4K9"/>
    <dbReference type="OrthoDB" id="5912168at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="267" mass="29757" checksum="2086DE3C2D7E6333" modified="2015-05-27" version="1">MLAVVVLLQFIQNSSHDIYSSFSGNLDYSWNRELQHICGDRFLPAICSATLISRRHALTAAHCVTTFTERRKKPGDKCSHKLIPESYIRVYPPTRVTNILRLEPFTSSFRVVKVTVHPNFDPCNKTGDVALLEISPNMFSDGAPICMPDANETIPKSLRAAGFGRNPKFHGKRYLQVVNLTLLLNYSEEIVTCSPGYTICAGDSGGPLFKTNETRYTLLGVASRGVKCEKDEDENVSFFEDVRPKLEWICKNSGICPMGFSTKPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4U6</accession>
    <name>A0A0D8Y4U6_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DICVIV_02795</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716192">
        <property type="protein sequence ID" value="KJH51034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4U6"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4U6"/>
    <dbReference type="OrthoDB" id="10056860at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJH51034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="397" mass="46487" checksum="10D14CF0BAF35D15" modified="2015-05-27" version="1">MKFCSESNVDPNAKNSEKPKKRKIGFRERRIIEYEDRIRLYSTPDKIFRYFATLKVIDKDDESGRFEVFMTPEDFLRSFTPGIMQPRKYGLDSYRIYQPNKHNHKFSDKKSIFYKLGENGLISFSDYLFLMTLLSTSPSDFALAFKIFDINGDGALDKEEFLKVQHLIMSQTTVGQRHRDHITPNSSFRVESNSALERYFFGEDGKKTLTASKFLEFQESLYSDILRMEFERRETMEGVSGLISEISFGELILMYAQLPRKKQKIMLKRIKKKFKSAKGITFEETKAFFQFLYHIEDVDMALHFHRMAGLAIDANLLKRVARKVTNVDLSDHVVDVIITLFDDNMDGKLSNNEMVSVMRRRMRRGLERPRDTGLFRLMDALYVCGKRSYRASPFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y523</accession>
    <name>A0A0D8Y523_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_02776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KN716191">
        <property type="protein sequence ID" value="KJH51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y523"/>
    <dbReference type="STRING" id="29172.A0A0D8Y523"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="357" mass="39593" checksum="D508B7C475A31BE0" modified="2015-05-27" version="1">MSPYAPCMTLGAGANQKHPHMRAMRAAVKSGDRLEEPLPDILTVMSVCNRAQFEHVRRSMRRVSTMRALQKSASEALLSGPVTKKFTIVDTRTGHVSERSRRNPPSTDCLSTVEKAVSELPSSPRATPITQRKSKNDIFGIPSDVALVKYVELHASVEAIRQRYHSVHEIPFNSIRRWQLVVSRCLVDVQPVEDIPEPSKNEARYVVMIKGAPEVILSNCKRARANDKVVDIDEKFRQECQMAWELLGNAGRRVIAFAQAHFNAPMNAKFANGENRWPEDLVFLGMAAIMDPPRPETAAAISQCKGAGIKVFMITGDHPTTAKAVATQIGLIGDMNDKTLSPLVYGIDLIFISIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y540</accession>
    <name>A0A0D8Y540_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_02026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716176">
        <property type="protein sequence ID" value="KJH51835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y540"/>
    <dbReference type="STRING" id="29172.A0A0D8Y540"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <end position="79"/>
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        </location>
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        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH51835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="495" mass="55267" checksum="E99E3990A778C757" modified="2015-05-27" version="1">MVKDLVIKCRGLPYSCDENALRKFLGDSGISKVNIIMRDGKAAGDAYVHYSNEDDYKRALKKDREHMGHRYIEVMPADEDSSRGTGSRDRDRSNFRDRSIRRERGYDYGRGSSRSAIPPLVPSAGEGVVRLRGLPYGVRERDVFDFFAPLDIVPDGILLPDERAAAKTNGEAFVVFVDQVTAERALMRHMKNMQHRYIEVFAASYGEMLQFCDEHRLRVPRGNGGGGSYGGLDRGAVYDDSYDGYLGSFGRVGGGDRVAAVGPWEDSRAAFGSVPITDPYLGGYNASAWASTDTRRPTSPRVGASYGDPYSRTGHSEHYGRVPSSEPYGRPAPVDDPYLRSSRRSDDVYSRGRSDPYESYTRGLTESWRDERSPAAATSGFGDSWHEYGYAGSGGGPIRVRDQWRDREDSRGPTAAAPRGRERPGQRYTLKMRGVPFRAIEADIYDFFEPVRPAHVEIIHEASGRPSGEARVEFASRKDYDDALLKDKHYMGMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y589</accession>
    <name>A0A0D8Y589_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="18">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DICVIV_04132</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="COX15/CtaA_fam"/>
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        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="345"/>
            <end position="363"/>
        </location>
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            <end position="393"/>
        </location>
    </feature>
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            <begin position="413"/>
            <end position="431"/>
        </location>
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        </location>
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            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJH49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="603" mass="69490" checksum="853A6DAB0F733241" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y5X8</accession>
    <name>A0A0D8Y5X8_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716184">
        <property type="protein sequence ID" value="KJH51389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y5X8"/>
    <dbReference type="OrthoDB" id="5878002at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="439" mass="48286" checksum="354FEDAD46F036BB" modified="2015-05-27" version="1">MIFQYAMSEESEVQSFNNSEESAPKAVFDKEHSGNVTKPRSSPTEPTVPNGDSNGHPEAAMDNIKTGDPPSTIKPLETLEDVTMDVNEPPEASEANAEGDIPPIEDKEESDSEKWEVIDDEELAKVKEAEADHTYRETQRLETIREVKNYDAETSKLELMDKSEEHPIITNEDMDVSMEKSEVSNELLSNLTPSTKAGRGRGRGRGRGRGRPAAAAGTPRTPRTPRVTTVIPDDAPSSIASSRPRRSTSTRVDYANPDTSTVLAEVDDEIPGKLFRSGRGRGGRGRGRGRGRKTADSDSDQPASDDDDIEFGSKKKRGAARGRGRGRGRGRGKGSGVTSHKGHDDSEDDDDNEMVFDDSKSEEAEAGSGDEVIPSKKRGANTDHNLPPKKRGRRNYFNYCVIYRCSCVVAAFHVTSMYADSPKYLYYLCQVLLYCLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y641</accession>
    <name>A0A0D8Y641_DICVI</name>
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        <submittedName>
            <fullName evidence="14">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_01640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y641"/>
    <dbReference type="STRING" id="29172.A0A0D8Y641"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="93"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="504"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH52175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="603" mass="68896" checksum="392C2C7735F2817D" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y6W5</accession>
    <name>A0A0D8Y6W5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_01923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716174">
        <property type="protein sequence ID" value="KJH51942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y6W5"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH51942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="94" mass="10943" checksum="5EAB492655DADC26" modified="2015-05-27" version="1">MPKLDRWNINITFCCGSLEKCSGDWSGSGAVWLRFEFRAHLIAMLSALETVKNFIRKSLSIDQHRSHFGNRMMKSRRCEIQISMHVTFVNAQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y818</accession>
    <name>A0A0D8Y818_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_01609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y818"/>
    <dbReference type="STRING" id="29172.A0A0D8Y818"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJH52144.1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
    <sequence length="662" mass="71394" checksum="C2D55741DFE89E2F" modified="2015-05-27" version="1"> </sequence>
</entry>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Choi Y.J."/>
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                <person name="Zhang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
    </evidence>
    <sequence length="300" mass="33528" checksum="17C96E00938E23AA" modified="2015-05-27" version="1">MVTMENLILKANVKLGGLNYVVELNGAIASESAKSWIRPGRLFLGISISHPPSSKNLDPDKDTPSVVGYAANFKENPFDFVGDYLYESPRREETLNTLSEILRIVIPKFAENHHGKRPRDLIIYRSGISEGSFSVVLTHEIPLLRGTLSAMGIKNIKIVFIVVQKTHNVRLMMMDIDRSRKPSEQNIPPGVVVDSQITHGSSRTPRYTVLVDDFNLSMDELEGMTYVLTYCHQIVNLPTSLPTPLYVANCYAERGRNIYEEHLLSSDSTSTESGASVDYGRFASRLSYNNTKLGSFRINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YAH7</accession>
    <name>A0A0D8YAH7_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_00699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YAH7"/>
    <dbReference type="STRING" id="29172.A0A0D8YAH7"/>
    <dbReference type="OrthoDB" id="5869749at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="206" mass="23792" checksum="92892E28BED05EFC" modified="2015-05-27" version="1">MLIAMSIVCCLIAMLTENSCLFYPFLFAVTFEFILSFTFNCLLIMKIGWPKAYVAFIKDNRLESLQNFTKIGEKGNELLFVWHGFRSLYFALLCLTLVKTITDYQINEHRRLHNRYNFPVVVPYPRAVVLPEQVQGDTNPDDPPPYSTIVRDDEQTAKEETLPPRYSECNHTSVSDSSRSTLTIHTAGRNGRNCHDFNKTIIIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YCA9</accession>
    <name>A0A0D8YCA9_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_01661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716169">
        <property type="protein sequence ID" value="KJH52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YCA9"/>
    <dbReference type="STRING" id="29172.A0A0D8YCA9"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="331" mass="38254" checksum="CCDB96E9FA899A49" modified="2015-05-27" version="1">MRTRADWVYATRIPKGKVVGRRWRIIRKLGEGGFGAVYKVEEIVTNELAALKAEANNKRGNVLRIEAKILHRLEGKPHVAQLIQTGKKDSYSYIVMTLLGDSLDKVLRRIGRVCSISSQIRIGIQVLFGLKQLHDAGFIHRDVKPGNLALGFHSTEQSRFIHILDFGLAREYIVVDTDGKTKMRRPRPNVRFRGTLRYCSADVQERCEQGRMDDLWCLLYIMVELRGPLPWANFQTLNYYLRPDYLLLYHVLEKIMVVNGIKFSDPFDWENDELQCKFCHFLPSALWSSQQKTESSDEVQDLLSTDTECSMESIEENLFPEEVFALDQYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YEI5</accession>
    <name>A0A0D8YEI5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_00731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KN716156">
        <property type="protein sequence ID" value="KJH53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8YEI5"/>
    <dbReference type="STRING" id="29172.A0A0D8YEI5"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="457" mass="53064" checksum="C86E4AFEF07EB03B" modified="2015-05-27" version="1">MVPAQGDDDPDVAYQTTMQWTTNSEGYGQTYTHCDQIIECNQEQRATTGRYECPIQSRLPFFNSLTPKFTYWCPKSTHAYNLLVELITSEYLKRGFHEAVTPNMYADSMWEPSGRCQYFSQEISRLEVLRYEMMTANCSGHCLFYGHRTPSYAELPIKYADFGAIHRSTELCYPLVLPYIYRFIEDDSHIFCRPDQITQEVKESLDLASLFYEQVMKFKIELKLSTRSADIEKWNDAEEALKIILKERSMLRVNDGAAPHYGPRIDIVVREPHGRYYLHGWLQLDFELPERFDLGYENEDGIRLRPVLLHRAVLAPAEIFLGIIGNECARLWPFWLSLQQVAVIPVCASSISYARKVVKELQDANFKVEANYKCTGTLNRRIKLAVSYKHTFTLVVGRNEAVNGTVNIRTRNDHVLGEFPFDEVLSEFRRFVNEYCDDLQCFQTFEKKSSFQNTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8YGC6</accession>
    <name>A0A0D8YGC6_DICVI</name>
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            <fullName evidence="2">PDZ domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">DICVIV_00160</name>
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    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716150">
        <property type="protein sequence ID" value="KJH53731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8YGC6"/>
    <dbReference type="OrthoDB" id="5865737at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040264">
        <property type="entry name" value="T15H9.4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31327:SF12">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH53731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="245" mass="28284" checksum="2D8FABE435DD4257" modified="2015-05-27" version="1">MVLLQEEHGRIERPPKRVVEELYRKTSGDEHQSTSPIQLPKGRLHNLNIRPGFAYYLVELRFVEGMKVGLYVKHYRNQVIISKVSTGSMASKSLRVLDRIIEVNNMPVTDKDVCKTLIINAIQNMGFVTLIVERPVERPAIEIMENALSESVQQPPSVAMPSDVRSIVRRHNEKISGGLNNIEPVKILKRPDSLPKYRPHIQIEDHNRDEYLIGMDNEHKNRKLHKVSKKNAKHSKRNSLRVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X5S5</accession>
    <name>A0A0D8X5S5_DICVI</name>
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        <name evidence="1" type="ORF">DICVIV_14221</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN719539">
        <property type="protein sequence ID" value="KJH39880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8X5S5"/>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="78" mass="8506" checksum="02E4E0E8F80ACCD4" modified="2015-05-27" version="1" fragment="single">MEIDWYQKKQYAFIAPGNIPAQNASMSQIPESLSRVGSKVSVAFRSGSVPATSLQGDLLNAADQITSNMGEFLRELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X672</accession>
    <name>A0A0D8X672_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718648">
        <property type="protein sequence ID" value="KJH40003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X672"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="7815" checksum="8EFBDC1510B8A7FF" modified="2015-05-27" version="1">MDKVGCAFYECESPQPRFVSFVCKYGGSDVKPETLLYLPGKPCQYCPEDCVSGSLCYRHKLKPKPTSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X680</accession>
    <name>A0A0D8X680_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN718294">
        <property type="protein sequence ID" value="KJH40050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8X680"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH40050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="70" mass="8121" checksum="E44014EAB24AF433" modified="2015-05-27" version="1">MITYKSGIDNTEDYAYGCCRKGEKFHALKSGVKSQRIIMIARLNKKKIITRLKRAYKSFKTTPNTNNTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8X7G9</accession>
    <name>A0A0D8X7G9_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_13547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716823">
        <property type="protein sequence ID" value="KJH41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XA26"/>
    <dbReference type="STRING" id="29172.A0A0D8XA26"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EXOCyst component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="174"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="343" mass="38910" checksum="EE59CB38CB9CA097" modified="2015-05-27" version="1" fragment="single">MSLDEIFAHCNYASKLFGNSLAGMQSGDDVTTYDNTALLSDNFSPSDYIRNKLKGVRTGDEKKKLQALRSDMSSLNRASQETLKNNVFQNYQQFIDASKEISHLEQEIYQLSSLLLDQKMLIENLMQMTGDDKLSVQTVSSHSTSATAIAPIQVLMQKMDGIANILNNMRSSDKVLLYGEMMQLDPETKEDVHRAMLVLLSDRLLIGNITSSGKYSLESTFSLKNLAVVNVKDRESGPALADQLLKLLVFPEQRYYRCDSSRVKKMWLDELEKAKREILRECIMERQSTIRGKRITVQERANRLQNPNAITQSINSEEAEEVNQDEIAWLQELPAELDDCIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XAV3</accession>
    <name>A0A0D8XAV3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716770">
        <property type="protein sequence ID" value="KJH41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XAV3"/>
    <dbReference type="STRING" id="29172.A0A0D8XAV3"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12259">
        <property type="entry name" value="RRM_SRSF11_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="353" mass="38613" checksum="023D85D5D4E86F48" modified="2015-05-27" version="1" fragment="single">MGADGKKEKIRILQVSNISVTATKDQIFTMFQYIGRIEEMKVYPSDMNITSATTSKCAFIKYDDDRAVEVGQHLTNTVLIDRAVVCAPYLQSVIPDEATFTNTGGPVTAGQRQLPPHVTNRVQELEDGTSVLLTADPQMEALGLPSYPPLPGNTDLAKVEEIRRTIYVGNLPKGVDGQVVLDFFNSYVGEVMYLRMAIAPDTLPCAYAYVEFTNQTSVPIALQNNGIDFQGRPLRIQHSRVAIIKPQAKSADQALEEVEEAIRMGKSNSSSTHLRSYSIIQTGDRVRVHLFGGVVLLHRLLAVKVDRLDVVEAVLGRSLGIAGEVERVQKSAKEVGRATESEAVARKDAGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB15</accession>
    <name>A0A0D8XB15_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_14447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN722102">
        <property type="protein sequence ID" value="KJH39671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB15"/>
    <dbReference type="STRING" id="29172.A0A0D8XB15"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH39671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="119" mass="13921" checksum="3C8CD3CC12577AA1" modified="2015-05-27" version="1">MQQNSSTDAEGVFVVPERKENNEISRGKVDCILRAKVHICTLRQCLKENICMHGSSENFCVVHYIPNVVHFAEYMSQHSLNLLGTEAYEFIKYRYESASAKRMKLDKENIRWFNVIHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XB47</accession>
    <name>A0A0D8XB47_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_13039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716936">
        <property type="protein sequence ID" value="KJH40997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XB47"/>
    <dbReference type="STRING" id="29172.A0A0D8XB47"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH40997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="225" mass="25605" checksum="F28CC9713F644939" modified="2015-05-27" version="1">MTYGSVKYCPYNNLINGVTSNSRQLGYFSLHPIITPRPIEKSMPITREMDYVVIASWAVWEYLSDAHIISILVNSINPQVAAKAIQDSLQACDYNGNSCVMVIRLLKPELSFSSTITDSEQSSSHILIPSMRIRRNKNEKSNQQKVQQNCRLESVGEVIREMEERPTVCEEKGYSSGREPHGRIAACDKVSRSEFTKSFILIVIRVRREKFELNSSFISSSYKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XBA6</accession>
    <name>A0A0D8XBA6_DICVI</name>
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        <submittedName>
            <fullName evidence="9">Paired box' domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_12124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716741">
        <property type="protein sequence ID" value="KJH41895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XBA6"/>
    <dbReference type="STRING" id="29172.A0A0D8XBA6"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="80"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH41895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="185" mass="20917" checksum="D19B0C24E500EDE1" modified="2015-05-27" version="1">MRINDLKELQTLVTRHLLASLFASGLVYRFRRPCVALMHPQVKNLVDKEYKNIMTRNELKSFSNDNQYGFLKIFMILNAGHTGVNQLGGVFVNGRPLPDTTRQKIVELAHGGARPCDISRILQFLNVVLKHTTLFILAVLGISTPIQINKVLRVERTTCVSKILCRYYESGTIRPRAIGGSKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC03</accession>
    <name>A0A0D8XC03_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_12754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716861">
        <property type="protein sequence ID" value="KJH41272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29172.A0A0D8XC03"/>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TBORCS5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH41272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="516" mass="57149" checksum="B46199A3248D5FA2" modified="2015-05-27" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XC72</accession>
    <name>A0A0D8XC72_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_11823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716698">
        <property type="protein sequence ID" value="KJH42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="388" mass="44388" checksum="17B5B10F5274FAB9" modified="2015-05-27" version="1">MSELKIAYVVDEDQISMLVDIFYLPFECGRRACELLERFLWLYRNAVVMNRSKLAEGIMDRAQEEWLQKFHDLNGSIQVVNSFFKNIVDCPNKALVSELIPYIWDAHGSCSVLLGLARWMKQGFVTVKPHDVLNLWNNDREDEPWMIGGGFLSECARLVAPQGPIMHLFNNRTLLPLSIMNYEIRPYTAADLDFLASLAITCIDEPNHSAIQRKELFLDRFVIPLLETSSQYCFLAQEVISCHENKLISSVAAHPNAHSLFDHIPMYISSLKAKYTSRKDNDFNVDHIDKWYPHVPDNIFDQYPAWLDARLLVDAYDSVPTRKLVQVAAAALYTNGCSGMFVTIPINSEDHVDFFSRIGFAELGKSLDGQFTMLGHLLSVNEDEHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XCB8</accession>
    <name>A0A0D8XCB8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_11760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="124"/>
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    </evidence>
    <sequence length="142" mass="16786" checksum="5A47B86F8C5A3152" modified="2015-05-27" version="1">MLAHQRFASQLHIRNRLFMKLCDMIFNVRSKGTLRRDKVPPCVGANLMKEWRDYIVEYHNSLRSEVARGEFRKAGGEEFPKAINMYEMQYSCSLEVDANDEAKKCLTNPSSSEFKTSRRNVYKLRTTYVSSERFAMLVFRRR</sequence>
</entry>
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            <authorList>
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            </authorList>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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            <begin position="218"/>
            <end position="235"/>
        </location>
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    <sequence length="256" mass="29238" checksum="559DF451F1E128C8" modified="2015-05-27" version="1">MNNQTVNDYPSHPPVLPISYKKLLNWSCNVFPGDDHTCVSTITTEKCRNGTQFSARYWGSAGSREKKGQFVSCVNMSVFFSLVLNDHEEETGLVEIFGFRSGPSSLLRHNISLRYLHPSPVIHYNSTSCVIPHRATLSFTHINGFINGAYLSSSYDYRTISDVENRIRISFRSQFIQYFELCQKSRFELQRSRFYCPSDVTCLQELWFPLDDLPTSTISVIGCITVVILVTVLTIKQNHLTYFNCDCRSVLSKAKL</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <position position="244"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="295"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
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    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="320" mass="36837" checksum="8E35D3C746137642" modified="2015-05-27" version="1">MESRLNDWGPDVFKIDELSKNHALTTITYALFRERGLIKTFEIPSSVFVTYLLNLEHHYRSNPYHNHIHAADVAQSMHVLLTSPVLTEVFSDLEVMAAIFAGAIHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLCGLSKKQRLQFRKIVIDMVNILITFELVDSAAPEVIHHRRARLVLCNDERKYNGVVVLATDMSKHMSLLADLKTMVEAKKVLQSMIHLADLSNPTKPIELYRQWNSRILEEYWRQGDREKELGIEVSPMCDRGNVTIEKSQVSTLIRSQGSSNFLRYLVYINHSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEG7</accession>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716716">
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    </dbReference>
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            <dbReference type="EMBL" id="KJH42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="77" mass="8765" checksum="0433433FEA87A6C7" modified="2015-05-27" version="1">METTGRFGNLHGDNQQIWKLKLIDQEKPMEVTINDSASTSQMFKVKSRNGSPPLLFVFSRIDLLLSDHHKEVGLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XEH1</accession>
    <name>A0A0D8XEH1_DICVI</name>
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        <name evidence="2" type="ORF">DICVIV_10952</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16936" checksum="68DF7FEE515C2FA6" modified="2015-05-27" version="1">MIVFEYLLLMRMSRLARGMEFNGETNKTLNGASGLMKMVYSFSAQKNEYDCKLEWYAQIWADKCKFEHSNRWERPNQGQNLFMTSFTDYDDISILHTAIELWWKELEEYGIPGDAMFSDELWRSKGSRIGHFTQVSKFSKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF76</accession>
    <name>A0A0D8XF76_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
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    </protein>
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        <name evidence="8" type="ORF">DICVIV_12937</name>
    </gene>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="96" mass="10725" checksum="F4DC801DBE0A86D5" modified="2015-05-27" version="1">MVSQAILWAAHILPFGLLWLACLTGFIPVIELVPDCDCLHHLVLYAPVYAVLLLGVYASLSVVHGVVTFNDCPSAKEELLREIQEARDDLKRRKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XF88</accession>
    <name>A0A0D8XF88_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ/DHR/GLGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_11607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716669">
        <property type="protein sequence ID" value="KJH42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XF88"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="311" mass="35689" checksum="5985DC46C96BF3DE" modified="2015-05-27" version="1">MILRVLPRSYFLSGSYITVFKFRKVFLVEFSSTCSCSSRKDGDDLEKELKKLAEVVGKDVDSALKKGETGIDKNFMNFKAQSERYVYNRTVFSWKVAAATLGIGVSCLAALLYIRKLRMEERERHMKYLAGKARIGGEWELVNTEGKLEGSEQLKGNWLLIYFGFTHCPDICPDEIEKMAKVVEILDSKPAKDKISIKPIFISVDPERDTPARVKEYCAEFSPKIQGYTGSQEQVNKVTKTFRVYYSKGPKTGRNADDYIVDHTVITYLIDPDGNFHDYYNRNRTAEEIADIIELKVFKYHAKNRKKILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFE8</accession>
    <name>A0A0D8XFE8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_11590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716667">
        <property type="protein sequence ID" value="KJH42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFE8"/>
    <dbReference type="STRING" id="29172.A0A0D8XFE8"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099631">
        <property type="term" value="C:postsynaptic endocytic zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00581">
        <property type="entry name" value="CLATHRIN_LIGHT_CHN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJH42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="295" mass="33228" checksum="73FE8F2D7E3AD567" modified="2015-05-27" version="1">MADPVADFLAREQDLLAEIDAAPIGPVINPVPVVPAAEQLGAMAVGPPSVGGGDSGVDLAGMDYQPAHTGMNDEAVPTFLFWELCFIMQTILCYNSTTSSKGSSPVPSLPRVEAENIRRWREQHKILLEKKDEAEEVKKNELRNCAKKELEEWYRQRDAALKLTKEANRKAEEEHLAAFSLEQGEGAQWDEIARLCEAKAQQKSGKDVSRLKSLLLHLKDRNRKWVSFIGTFFAKYLSTVRNVLMAEKQLCLPGFLPVWRESPILLLFVALWHLLTLRTISRVMLLNIKSNQDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFI5</accession>
    <name>A0A0D8XFI5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716561">
        <property type="protein sequence ID" value="KJH43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFI5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFI5"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052782">
        <property type="entry name" value="Oocyte-zygote_transition_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46163">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18667" checksum="7ED9FCB91C554A60" modified="2015-05-27" version="1">MFMARKQSSVVRKVSSSLVHHFLFPDWPDHTAPLDPVPVVKMVKTARQLCNNNPIVVHCSAGIGRSVCFIGIDYISQKVKEDSNVKMLDMLIYLRNQRLQGIQSVIQYTFLHICVLELFVQDKIIPREGKYSEFLNAYVKMLTNYNRRVATMLSKDTDDGTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XFM5</accession>
    <name>A0A0D8XFM5_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DICVIV_10519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716556">
        <property type="protein sequence ID" value="KJH43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XFM5"/>
    <dbReference type="STRING" id="29172.A0A0D8XFM5"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF6">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="103"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJH43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="259" mass="28939" checksum="A6514843EB6AD9C9" modified="2015-05-27" version="1">MNIIGVHRTANLKKLGMHSSDTAEIFFDNVRVPACHIIGEEGQGFFYQMLQFQDERLVAAAVLLEPIQRCITLTAEYAGERKIFGSTVLNQQVPACHIIGEEGQGFFYQMLQFQDERLVAAAVLLEPIQRCITLTAEYAGERKIFGSTVLNQQTVHFTLAELQSELEAVRSLLYRAVLSRIHGEDVTLLASMVKLKAGRLARIVTDSCLQFWGGNGFTWDNPICRMHRDLRLHSVGAGADEVMLSIICKQMGIAPAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH45</accession>
    <name>A0A0D8XH45_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-binding protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716510">
        <property type="protein sequence ID" value="KJH43985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH45"/>
    <dbReference type="STRING" id="29172.A0A0D8XH45"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="191" mass="22094" checksum="A4133AA6CDD14E54" modified="2015-05-27" version="1">MPIRKNHYFSMPELEARNDVRIPNIGSSAKALSSRSDSCADSVLNYSELEYDDSPLDQKHLNLVHEELEKLNIATDVINKLEVQLDAARVSFREIQACWSEKLKELSKKYSSAIAKARPYYEAKIQERKLRDESLRAAIRFERATSLLAVAKQQVALTQDSLNRQTMVHPECLEVYKCIDFFIRETCSRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XH75</accession>
    <name>A0A0D8XH75_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716512">
        <property type="protein sequence ID" value="KJH43958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XH75"/>
    <dbReference type="OrthoDB" id="5827199at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="109" mass="11515" checksum="78357FA3A66598B0" modified="2015-05-27" version="1">MKTAVFGHDSGGDGPTASCCGAPSLTFTPPASLALAPNHQRRTGGGTLSATGAGTARPHSRRTSRMQNVGCKSDMIRIVGKNNVRINYFVFGLGVKNYKIDFSQSNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHK8</accession>
    <name>A0A0D8XHK8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Niemann-Pick C1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_10796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716583">
        <property type="protein sequence ID" value="KJH43197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XHK8"/>
    <dbReference type="STRING" id="29172.A0A0D8XHK8"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Niemann-Pick C1 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="393" mass="45753" checksum="26E85CD0A4D0F92A" modified="2015-05-27" version="1">MINRNTSGKPTEVDVTLGKWVKRRYILEDNVRAKMSSPMNCRVDENFTALPLYSLSNDAVEKLEYMCPHLLEDNDAFAAHQHKYLQMNKQLRQASNLLERCPSCYDNFQKLWCEFTCSPRQHKFMKVLQEIYVPESNVSYVNKVRYNVSQEFTDSLYNSCKDVTMTGSSTKAIRLMCGSLNKYEECTIDNWLKFMGTQNHRIGTPLGIEFNIISAKERQMDGMDYFMTVPTTPCHMSPRYGRPKCSKQDCTAVQVVDLFPKDEGTKEVCQVLGMGCKVFLLFGSLFIFAGVLIFMGFLHLFHNTSTTDSELEHIDYKSVSTNMGRIRTMGAWIQDQLKYNGEMFGRVCAFFRLFFQSHFFAILVRCPTCMVCVFIRSLYCNYFNFWKRFFEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XHQ1</accession>
    <name>A0A0D8XHQ1_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_09803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
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            <begin position="115"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="161" mass="18764" checksum="00EE9FF873435748" modified="2015-05-27" version="1">MPCTSYRRRVIRNISPSRAASEIHTISNSKRRRSETKTRSVTFANDTFKSSASSASVHRRKNRTLRSSKRRTSSQRSRSVSSSRSQRSSRSRSKRKERVKKTRSTMSDGSEKSKSRSNRGLVKRRRSRRQALTGELVMRCFLRVKTKARKPRRRDSKGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XJA9</accession>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="121"/>
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        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF00149"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="317" mass="35516" checksum="44E574D8C7D69B12" modified="2015-05-27" version="1">MYWCPWRTICFQDVARSSLLIFLALSQCSFLFYFFLLGNSFLNCCYGTEPHILAQISLIGLATYLHVIVFLVITELILTVCTMLSKCGVFTLVVRRITTNRHKLTLLSIFCAFIFIIAGIYETFTDPVYTHVSIPLKKLHFDELRVALLSDLHIGPTVGRQRIETIARLTNKLNPDIIAISGDLADGFVENFGNAASPLCSLRAKYGVYFATGNHEYMHGNVEEWFTFLEVCNITVLHNLQQRFRLTNGTDVCIAGADDLFAAKSRFPGHIMDPRKAVNGCRTNDIVVMLAHQPNAARLMLNDPAVNNKLDVILSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLF4</accession>
    <name>A0A0D8XLF4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_08502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716407">
        <property type="protein sequence ID" value="KJH45463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLF4"/>
    <dbReference type="OrthoDB" id="5875259at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37439:SF1">
        <property type="entry name" value="PROTEIN CBG18706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37439">
        <property type="entry name" value="PROTEIN CBG25991-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH45463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="261" mass="28956" checksum="207B4FB6369BAB21" modified="2015-05-27" version="1">MRNNQFKISGIAPFVPPVGVQPRLRPPDDNETINEVISNWGAAQAMVKKQAEAKIILVRNQFLNYPTVFETVKAIGHCSCSTSRPACGNSTLRPPDDNETINEVVSNWGAAQAMVKKQTGAPNPSAPVVPPVGVKPKLRPQDDNETINEVVSNWGAAQAMVQKRAPARKPIERQRTSHGNDTFNDVVSDWNPGQTMIQKKDADQVRPPHQKTTTVEPTAQKDKFRKANDNETIDECVSDWGAVQVMKKKKVFKERKEKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLR6</accession>
    <name>A0A0D8XLR6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin p58/p45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_10665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716571">
        <property type="protein sequence ID" value="KJH43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLR6"/>
    <dbReference type="STRING" id="29172.A0A0D8XLR6"/>
    <dbReference type="OrthoDB" id="5873702at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="48469" checksum="C24693092E964DD4" modified="2015-05-27" version="1">MSSQITPKTTAASGLFGVTATTSSTTTFAPTSSTTTGGLFGVTSTSTTTTASGGLLFGIKTTSSATPGLFSGSTMTGSLFGAKTTLPSLFESTTAISTATTMTTAPSLGLGGTTHHSGLSTISGVGTATAGTTSEKENWREGIVPKPIREVVLQIREKIKENKKLTEEFNSASNDGTIKVKERLKEVEHRLYEAYSRTVECDLKCAQLSGRVAKDVQLGDIAQRVQESVSKNIHFSSHTQIIQYIVDIIREYDDAVIWYQNTIEDIEMKLTAMLSGKGSLTVNDLKEMLTRFDIAFSRVAIKLFDASRKVQDVKSVLTADGAMYMLRDALNRRMDASSRMQSFGSLRGNDFVPSQSVIAELGKQLKPAAGTTHPTTGTGLFGSTTSGTLFGSNAAAAKPFSFATTSSGGTSLFPSLTTTTVTPLFSSLTSTTSTASKPALCFGSTITNNSSGLLFSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XLS6</accession>
    <name>A0A0D8XLS6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_09294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716456">
        <property type="protein sequence ID" value="KJH44687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XLS6"/>
    <dbReference type="STRING" id="29172.A0A0D8XLS6"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="279"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH44687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="536" mass="61230" checksum="B908744925D8B4E4" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XMB0</accession>
    <name>A0A0D8XMB0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DICVIV_08194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">HannoverDv2000</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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    </evidence>
    <sequence length="251" mass="28073" checksum="18EB261C7D6381C4" modified="2015-05-27" version="1">MQSSPPTEAEIAARTEERKKAGDANLSYVVAFNGIDNENKHILTQKIRFLGGSVCEQVSECTHLVTPNGRRTERLLEAICLGKNIVNPYWVVHGYECRQWMVEPSRGVLKKLICIAGGIVHDDRPAPADIEFLFCQHAVLKQMHLSSSSVVSVIFEWFNILLNAISSLIDDFSVILSGNFAMYVPLAVYNADFVLIALIRQELEPHPLYRVNTASLAKPPVPQPATSHSHYRPVPSRPMIDQQPQPHRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="151" mass="16356" checksum="95E1774BBB8C3F52" modified="2015-05-27" version="1">MLELLLQLFCIFGSMCFMCLCAQPKEEKSQGRMPINNRGTVLEQKSIGQSLVEGKQKADQECKNASKLSSNQKLDQISKQKSRADGVSNKTPLDGSVPKSAKELKSINDAEATSGMQPENMALLAAAEQMALDKADYDNFGPPGKPEAKST</sequence>
</entry>
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    <accession>A0A0D8XNG8</accession>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="133"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH43921.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
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    </evidence>
    <sequence length="188" mass="20656" checksum="E28F6158BAEA69D2" modified="2015-05-27" version="1">MCDVRAEKSGIALEAQQKIRDKYDSELASQILQWVQSITGEDFDTEGSIDNFCSLFKDGTLLCRLANSLQPGAVNKINKSAMAFKQMENIAFFLAFAQNHIAKSELFQTVDLYEAQDPNAVLVCLSSIARKSEKIFGKPGLGPKESEGEKREWTQEQLKAGQSVIGLQMGSNKGATASGINFGNTRHM</sequence>
</entry>
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    <accession>A0A0D8XQD7</accession>
    <name>A0A0D8XQD7_DICVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716461">
        <property type="protein sequence ID" value="KJH44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="128" mass="15151" checksum="7EC69D929FCFBC5D" modified="2015-05-27" version="1">MEWTLSRDAYAFDFVGIVGIIEAVWILAFGFDQLLMKELNEFSKNCVNLNEMKCLVGLGDAFNRQISCKDRCIRIYQRTLARVGFDDAKLRELLEKQRPLGTIKDICWFKIFTWSHREQKTEMNNERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRM6</accession>
    <name>A0A0D8XRM6_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_07501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716353">
        <property type="protein sequence ID" value="KJH46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRM6"/>
    <dbReference type="STRING" id="29172.A0A0D8XRM6"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000040">
        <property type="entry name" value="EXOSome (Multiexonuclease complex) component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="252" mass="28054" checksum="30FFF866462CC422" modified="2015-05-27" version="1">MILLLHLAFKRLDGRTLNDFRQVKLVVGSDPGTALCTMGDTKVLCVVSISLAEPRTSRPSKGLVTVDVDMSPMSNPANEANRLGEKGLELTRMLELVLRDSRCIDVESLCIRAHKEVWKLRIDVRILDDDGSLLDCASIAAITALYHFRRPNVTIQPNHTIIVSSYNILQLLLFSIYSEYEQALVPLNIYHMPICVSFGFTKCGTCVVIDPTDKETQCLYGCLVIACNKRREVCALHQSTNLILNTNTVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XRU4</accession>
    <name>A0A0D8XRU4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">transketolase</fullName>
            <ecNumber evidence="9">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DICVIV_06679</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KN716316">
        <property type="protein sequence ID" value="KJH47225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XRU4"/>
    <dbReference type="STRING" id="29172.A0A0D8XRU4"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="308"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00861"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="612" mass="65843" checksum="4593581F8D3743A7" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
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            <begin position="112"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditomorpha</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XS74"/>
    <dbReference type="Proteomes" id="UP000053766">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH46609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="168" mass="19159" checksum="D4A478253D757562" modified="2015-05-27" version="1">MRNYETAYKHSVVVSLTVEDLLKIKVQQVQQCRLHETNSYDFRRRHAIKDRLIEMRKSMDGDGCGGGGGSVRDYCRLGECRTRENLTSALAVMLAMKTFNGAIVVEEKKRVELKSNSIVFCHEVRKFEDEALRDNGRNQWQCGRLVMGGVTRCPLTTRGKKKSPTLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XSE3</accession>
    <name>A0A0D8XSE3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Linker histone H1 and H5 family protein</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">DICVIV_06481</name>
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    <organism evidence="10 11">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
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        <lineage>
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">HannoverDv2000</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="173" mass="18496" checksum="15B1E4CB9107DF47" modified="2015-05-27" version="1">MSAATATSPKVSKPKTTKVASSHPTYSAMIRKAVTELKDKSGSSKAAILKYVLSHYKLGDNVTKINTQLRTALKRGVIKGELKQVKGIGASGSFKLAEKKEATASKKTTVKKPASKVAKTVKRATKKPKAEKKTKSPKKAKTPKAKSAKKPVAKSAKPKTTKHKTSKTKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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    <protein>
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        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
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                <person name="Hallsworth Pepin K."/>
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">HannoverDv2000</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716385">
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
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        </source>
    </evidence>
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        </source>
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    <sequence length="405" mass="46032" checksum="6E0F31C12C9B7E97" modified="2015-05-27" version="1">MTALTSLRLLTSSYCTELKSIQSTPQYHGKDGGVTVSKASRQAKGNLFHMRLGRLARKCDGVISRDCMIFRECKNNLTFHDDHFQSAALDFLQEKNVSSLQNKHQKGLQIENYRFGWICGDESYLMPAFSQVQFFGVLFGTILFGSISDIFGRKPITVLTLSTGFLLNLLSGFATSWKILHTVRFLLGFCIGGTIVTLATLVTELLLPEQRMLLRGIFNWGIARLILTTVCMIFPNWRSASIVCALLLLPPIFCIIFVFPESPTWLHNKGRLMELQKVEQYIAEITGKKYEYVQKKSIEHVKTFYEMWRSPGLFRRLGVLWLMWFIASFSSYSNDLNSNTISGNLFVNQILFAILITISKLLTTPSSLSLLLKKQLENFMLFVVIVGFLSNAIIYCISVSISQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XTZ8</accession>
    <name>A0A0D8XTZ8_DICVI</name>
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        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
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            <taxon>Strongyloidea</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716284">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5876908at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11445" checksum="AFCE42B622E69C30" modified="2015-05-27" version="1">MDRSIAYISYSRSAMSTTEDIRSQWKNLKDTFVRKLRWVSEGNLDLVKNELHHMQYDTSNQSTASSEEQMLSLFAQVIRFFIDHQEFSYKNSLHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XUK1</accession>
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        <submittedName>
            <fullName evidence="5">PDZ/DHR/GLGF domain protein</fullName>
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        <name evidence="5" type="ORF">DICVIV_05645</name>
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    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
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                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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            <end position="685"/>
        </location>
    </feature>
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        <location>
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            <end position="1222"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJH48283.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="1222" mass="135464" checksum="307E97F8312B92A3" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XV63</accession>
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        <submittedName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mitreva M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
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            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <end position="127"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH48518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="137" mass="14883" checksum="35596A7A5169B9E7" modified="2015-05-27" version="1">MHMLLINSLLLAFTIEAIGATTTTASMTTVTVNSTTSNSTTSPTTAIDKKCEDVLKNCSKYLSTICGNLAYRSLMKTKCAKTCKLCNVTCFDKAKKCSEWNSSGFCASNFYSNEVKMKYCAATCNLCEGDSKNTQKP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
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                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF1647"/>
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    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH47096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="408" mass="47453" checksum="F8A1BEF4F5DE4D11" modified="2015-05-27" version="1">MVFVLQKLCELRKASNHMLQKKIFQGNVIYLALLTRFVVACLFLTALRYFLLDYVSNENFCLCTDAHGNSYNFCYHSKGNPSIVGKRFTCDHLEKLRDLSSNLDGPSPREMRSPVISYLFLTSAAVAHSGGFCAYGDSGLAYYIASIRKYYKTAKIVVYDIGLSKKNAMRVKRWCHVDYRRFQFEKYPSYFKQLYTFRWKPIVIAEALKNHDVIWYMDTSIILNKSDLRHVYALVSCKFKSRVRFSMSTTEERDMREHNYHTEYAWDTVQWRANVDECRKATIYEYFPVSLEEMKKPKAKMYEAGLVSVLCALEEECMGTKIIPNTCRFDRIDLYASFPHCHRDICLSKFLYSYTNVEQLKPEAITDSDPNLQNAANKRISPMAAFVHLHSKKKKIQLPGQTGLSQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XXV4</accession>
    <name>A0A0D8XXV4_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Globin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DICVIV_04367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716233">
        <property type="protein sequence ID" value="KJH49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XXV4"/>
    <dbReference type="STRING" id="29172.A0A0D8XXV4"/>
    <dbReference type="OrthoDB" id="5783368at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJH49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23870" checksum="49C43B413E2C261F" modified="2015-05-27" version="1">MSVTDEKQDEPEASQNTVIITPSEKRYLKLSWEKIPYLLNKCFRASNAVDIGCELVAALLNDNRTRFRAFIQSHTNDVLGTATFTAEDVRKYERALAVANGVVVFFNKLISKLDEPNCAELIALQSQHLGASHFRMKVWFQAENWLCVKNCLLSTIMKGLTQKSESQLTSNKSNYKGINLNPYELILYIAKKISDSNEEALTVDGSSGKTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYG1</accession>
    <name>A0A0D8XYG1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein kinase C</fullName>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DICVIV_04323</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="EMBL" id="KN716231">
        <property type="protein sequence ID" value="KJH49535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYG1"/>
    <dbReference type="STRING" id="29172.A0A0D8XYG1"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20795">
        <property type="entry name" value="C1_PKD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJH49535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="184" mass="20590" checksum="034260C642DB3D8D" modified="2015-05-27" version="1">MQILAIACPHHERLVVHPHTLYVHSYKAPTFCDFCGELLFGLVKQGLKCQGCGLNYHKRCASKIPNNCNGSRQRRPSAIPLSPSSSNMLNLEERRQSRRDSCLEALDAARPSSTTGGAHLTPEIYITPDTDYGDPVGGNFLQMPRKDRSCSWSGRPLWMEVAEATRVKVSRNDAQIEIFHKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYP5</accession>
    <name>A0A0D8XYP5_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zasp-like motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_05005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716253">
        <property type="protein sequence ID" value="KJH48879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYP5"/>
    <dbReference type="STRING" id="29172.A0A0D8XYP5"/>
    <dbReference type="OrthoDB" id="5919374at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJH48879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="622" mass="71327" checksum="B490ABFDAA1D7763" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XYS8</accession>
    <name>A0A0D8XYS8_DICVI</name>
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        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_04250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716228">
        <property type="protein sequence ID" value="KJH49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XYS8"/>
    <dbReference type="STRING" id="29172.A0A0D8XYS8"/>
    <dbReference type="OrthoDB" id="10035043at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="378" mass="42836" checksum="3FCBFC9901AB6A16" modified="2015-05-27" version="1">MQENACFSHFINNFIVIEALEPRTMLGRFLRSFAIGTENYQILISGKPSSDTERRNLLSDAITLMFFFTGIQCTLVMMGFLQERIITRGYLATEIAQIDKFGDAQFLVFCNRIVGILVCAIVLALTWKKQPPHAQPYYVHSYTSISNTMSTWCQYEALKYVSFPTQTICKTSKVVVTMLMGLVLRGQKYTWQEWACGGAVGLGAGLFLLGSGRSKHEGVVTSVSGMLLMLGYLVFDSYTLNYQKKLFDKKPKISKYQMMMGVNVFSAILCIVSLIEQGTLFTSIEFAFIHEGFFRDAFLLSLSGATGQLFIYSTIEKFGPIVFAVMMTIRQMLSILLSSFYYGHSLSSWSLIGFGIVFTAIFLDIYRRYFERRQSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8XZI3</accession>
    <name>A0A0D8XZI3_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DICVIV_06203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0729 family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716295">
        <property type="protein sequence ID" value="KJH47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8XZI3"/>
    <dbReference type="OrthoDB" id="10062823at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729_C18orf32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13456:SF0">
        <property type="entry name" value="UPF0729 PROTEIN C18ORF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJH47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="78" mass="8598" checksum="2B212286EE4F028E" modified="2015-05-27" version="1">MVCVPCIFLPILLAIYLYFIQPLVLRFLPQRWVSALDSILYPTCPAKPPTNANEAHSSNSASLDCDGSQSSKEGKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y075</accession>
    <name>A0A0D8Y075_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DICVIV_04325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KN716231">
        <property type="protein sequence ID" value="KJH49537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y075"/>
    <dbReference type="STRING" id="29172.A0A0D8Y075"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJH49537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="43230" checksum="D57A795823D0F40B" modified="2015-05-27" version="1">MKRSISFIAGSPSDENSFETAQSWSAAIQAALMPVTPQSSIGGHKKGVTEMMKLQVPNEGEKGQLGSTIQTEQEFSQLYQIFAEEVLGSGQFGTVYGGIHRKSGKHVAVKLIDKLKFPPNKEDLLRTEVNILQKVHHPGVVDFLQMLETPDRIFVVMEKLKGDMLEMILSSEKGRLSERITQFLVAQILVALRYLHNQNIVHCDLKPENILLTSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDIHDQIQNAEFMYPPNPWKDIGDFAIDFINGLLQVKMNKRFTVSKALSHIWMQGYELWSDLRLLEKTVGERFLTHESDDARWNEFEKSNKLTPVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0D8</accession>
    <name>A0A0D8Y0D8_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DICVIV_04269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="EMBL" id="KN716229">
        <property type="protein sequence ID" value="KJH49602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0D8"/>
    <dbReference type="STRING" id="29172.A0A0D8Y0D8"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJH49602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="555" mass="61378" checksum="B75B00C37587C6AD" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0H1</accession>
    <name>A0A0D8Y0H1_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
        <property type="protein sequence ID" value="KJH49642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y0H1"/>
    <dbReference type="OrthoDB" id="5917524at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990834">
        <property type="term" value="P:response to odorant"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010558">
        <property type="entry name" value="Ly-6-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34722:SF4">
        <property type="entry name" value="HOMOLOG OF ODR-2 (TWO)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06579">
        <property type="entry name" value="Ly-6_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH49642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20252" checksum="2A9B98A3845C9E01" modified="2015-05-27" version="1">MDQAYVYLKKFHNLILGSVPRQIECFSCMSLSYQTSWKYLQTTYIYPKVFTDRCQDPSSERGMPTVSCSTVCISLLEPDIEAGVFIGYKHIRGCMDRVLRHGFNQTALRTHRFQHHNQCRTLSRAHLFNPARAADPPAIGDVQLCSCYGDRCNGSNQAQLRAVITSVMMAIVFSIIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y0H4</accession>
    <name>A0A0D8Y0H4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DICVIV_04192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716227">
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <strain evidence="6">HannoverDv2000</strain>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="136" mass="16170" checksum="F6F744C0F77BACBF" modified="2015-05-27" version="1">MTEDVDGHVLDKYDLQKRLGKGAYGIVWKAVDKKTKDVIALKKIFDAFRNQTDSQRTFREVMFLQEFGKHPNVIKLFNIHKADNDRDIYLVFEYMEADLHNVIKKMTILKDIHKQYIMCQLFRAIRFLHSGNVLHR</sequence>
</entry>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="218" mass="24231" checksum="6F0D85A5009BC400" modified="2015-05-27" version="1">MWTLQRTKNNADMPPPLHPGSPLLTWLAPVKSRSRVTHEPDTWISQVEVCTYSGPHRRLWMGPQFKFFEYREENSSAELVGNDIFASISLSRTSMILVIQSNMFCVFKMTPSESRHSLSSIKSVPVVIGGAGSSCSNSEATRIECGSWASEVSVSMGDSINASGDITVQIADAMRDLEIEEQQGSGEVFFDTSPGIRRKSLKTQTVVDEEDLDFDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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            <taxon>Rhabditina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002336398" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13703" checksum="007C82B89DC16582" modified="2015-05-27" version="1">MLHLSRLGMLLLVCIVSVTVNSQLQQSDDEQMNEERLAKASPIWMNAKRARNPYSWMAAEEVNSARNPYYWMGQTKGKRLIRYADQIYSHPRNPYSWMYTMFDKRTNTPYSWMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2E0</accession>
    <name>A0A0D8Y2E0_DICVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DICVIV_02929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH50875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9843" checksum="B7BDBB5CD391FBA5" modified="2015-05-27" version="1">MHTRHTSSAQTPSIFRAKGFGSDRRHQSIESKSSVHRRPAYFSHIYNETMKKKTKCFSMVMKRKFKDISTALQSEHISQGPVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y2G0</accession>
    <name>A0A0D8Y2G0_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemicentin-1-like von Willebrand factor A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DICVIV_05150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Rhabditina</taxon>
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            <taxon>Metastrongylidae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">HannoverDv2000</strain>
        </source>
    </reference>
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            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="147"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJH48756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="381" mass="42984" checksum="02F3EA85261BEF16" modified="2015-05-27" version="1">MFDDLVQVREGAKKIFQTVMQQREKLIYNYIMVPFHDPYLGEIINTTDAAYFMRQLGKVYVHGGGDCPEKTLTGIQKALEISLPSSFIYVFTDARSKDYDLEDTVLNMIQEKQSSVVFVMTGDCGNRTHPGFRVYEKIAAASFGQVHMLYEVRERGGTVIRNISVDKHMTELTLSLSGDKDDEDILDITLKDPSGRFTDKNIYSREGGTIDLKNVKLIRLKDPQPGTWQVITNSRLKHTIRIFGHGTIDFKYGFGTRLLDRIELAHPRPISNQNSYLMVNMTGLIPPGTANEIALLDYYGNIIYSDEATIYRSNQHMYFIGPFVPPKGLFFVQVKGFDEDKYAYQRIAATAIGSVTVGGPRAYMNPTTTAFIAMVAFQGNP</sequence>
</entry>
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    <accession>A0A0D8Y2N6</accession>
    <name>A0A0D8Y2N6_DICVI</name>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
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            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716210">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="10">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50173"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <sequence length="634" mass="71506" checksum="29ADAF02D73E43D8" modified="2015-05-27" version="1"> </sequence>
</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
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    </reference>
    <dbReference type="EMBL" id="KN716253">
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            <begin position="1"/>
            <end position="23"/>
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    </evidence>
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    </evidence>
    <sequence length="98" mass="11010" checksum="87882A632B6E0602" modified="2015-05-27" version="1">MHRHVQFPLRPPATSGQSSKGSTDWPLTLQLCGTICQYSLIKFAATVWNSSPYVCSSDFVSTYRRMNIKKVIKAKSSQLVRVTPNRARLLTVVGARRL</sequence>
</entry>
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    <accession>A0A0D8Y320</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
    <dbReference type="EMBL" id="KN716206">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="63" mass="7316" checksum="1BFC1873C98E9B9B" modified="2015-05-27" version="1">MLPYKPQSLGSLFSLFTQYISLLFIKRFFESIFGRSSEKLKLYITSTGEECEFGGHEIENNNE</sequence>
</entry>
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    <accession>A0A0D8Y3D0</accession>
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    <organism evidence="1 2">
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">HannoverDv2000</strain>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12945" checksum="3E66263C5A49BD91" modified="2015-05-27" version="1">MCAVLGILVKNEGESNFEFMLRSPNVSIICANHVSVLDHLAVDLVEPCVLPSVWDIPSVIRWCFGYLDFGARDGHAELVRRVSDYLGKNDLPVLSFPEGAITSGRVGILRFKSMHIC</sequence>
</entry>
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                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <location>
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            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51373.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="299" mass="33315" checksum="BF610DE02E2F4063" modified="2015-05-27" version="1">MCSDRPMTTGAMVREGYIDVPAIARLIVLCTFGNPPNLSARQLDSVCSIAAYYDSKEDHCDIPDDYWKQANPDNMCSDRPMTTGAMVREGYIDVPAITRLIVLCTFGNPPNLSARQLDSVRSIAAHYDSKEGHCELKFVSEVVARMKGAIRSGIVVLHCPSYVTLQFASYYADELSAWILDEIYSPGNTNTNMALDLARQMIYPEKTIAKTIIFLSDGEDNNCTWGSPANLTETMFEIADDIRSKGIKFLFIQVGHEFDENVLKAVNYNKDDIISVNDYMALDSSVTVNVVNKICHVFD</sequence>
</entry>
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    <accession>A0A0D8Y3G3</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">HannoverDv2000</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716245">
        <property type="protein sequence ID" value="KJH49126.1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJH49126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18893" checksum="688729E0488D291E" modified="2015-05-27" version="1">MLLPCLPTFPDGLPSIDEKTFEKIARKTLIILPSVATNERLKLDENELVSESFELSREQLEKLSCLHTSYVDAVSRVWYSNGPSISKHFARQTATNKPRVKDISWSIWTQLASCQSTEEDGEPGVQLIISTDRGVMIFNLSYQEVARLHRETVRIQAEIDKLLEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3M3</accession>
    <name>A0A0D8Y3M3_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DICVIV_02385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KN716183">
        <property type="protein sequence ID" value="KJH51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29172.A0A0D8Y3M3"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000172">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="2088"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2030"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2212"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJH51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="2241" mass="260344" checksum="2F797C9A45AB5EE1" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y3W4</accession>
    <name>A0A0D8Y3W4_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, C2H2 type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DICVIV_02211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716180">
        <property type="protein sequence ID" value="KJH51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y3W4"/>
    <dbReference type="STRING" id="29172.A0A0D8Y3W4"/>
    <dbReference type="OrthoDB" id="10014897at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJH51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="204" mass="23358" checksum="97044198D2BDA7D1" modified="2015-05-27" version="1">MSRRKQLKPQPVKDDVLSSSDVVNGEETRPRKRSFPNDVKAEPSCNDEVRSLSTNDELKLNCQFCGASYETISDLQSHTIRDHVPMPTPSSLECQHCFATLPSFAAFVIHMRGHLNDREDTRCSKCPLSFIDTQSRLLHLVSHFEVRKTSRVCVECGISVADNLMLGQHFIKRHLRIQHLCMVCGQTNDTQREFIVSYLVFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y4L0</accession>
    <name>A0A0D8Y4L0_DICVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cation transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DICVIV_02900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KN716194">
        <property type="protein sequence ID" value="KJH50939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y4L0"/>
    <dbReference type="STRING" id="29172.A0A0D8Y4L0"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000084">
        <property type="entry name" value="Glutamate-gated chloride channel subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="94"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="265"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJH50939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="443" mass="50643" checksum="612510D0644968D7" modified="2015-05-27" version="1">MSSKNSLKQSKESVTDEEYSDIDDLDEILAGDLDSPDFIIEASSSLDDNGNSMKTSNKEMINMVPSANPTTLEDIARIQIVERKPIEQPQSSNTEILEKLLSRGYDWRVRPPPKDGAIHNGPVVVSVNMLIRSISKIDNVNMEYSVQLTFRESWLDERLKFGVSSDDLPEFVILTAGHQIWMPDSFFQNEKQAYKHMIDKPNVLIRVHKDGTILYSVRISMVLSCPMHLQNTQIIVLSNGRTTMLYRSSLVCVHYKGHCYYLLQLYIPSCMLVIVSWVSFWIDRTAVPARVTLGVTTLLTMTTQSSGINAKLPPVAYIKAIDVWIGACLTFIFGALLEFAWVTYIANRSHLNNKKEKRNKPIVIKMTNDVWVPRVAIEQEIEKTKAIRNSPHLPGFICRWLTQTIDWHDEAKRADLISRLLFPLLFVSFNIAYWIHYAQYQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y561</accession>
    <name>A0A0D8Y561_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="3 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DICVIV_01939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
            <taxon>Strongyloidea</taxon>
            <taxon>Metastrongylidae</taxon>
            <taxon>Dictyocaulus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
            <authorList>
                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">HannoverDv2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 11"/>
    <dbReference type="EMBL" id="KN716175">
        <property type="protein sequence ID" value="KJH51860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D8Y561"/>
    <dbReference type="STRING" id="29172.A0A0D8Y561"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="49"/>
            <end position="357"/>
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    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="318"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJH51860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <sequence length="365" mass="40263" checksum="5C2D26FCA11846F5" modified="2015-05-27" version="1">MAMIHAKRRVIIRYKRKFPPGMIVVSENILLGCGNPLLDIQATVDKNFLKKWGLKENDAILCDEKHNAMFDELVENFEVEYVPGGATQNAIRVCQWILNLPNRASFFGAIGKDKFGEMLSTKTREAGVNARYQINEIVKTGTCAVLINGQNRSLCAHLAAANTFTLDHLLEPESKEIIESAQFFYIAGFFLTVSLPSIMHIAKHSYNHGKTFLFNLAAPFISQFFFTSLSEVFPYIDILFGNEDEAAAFAKAAGFDTADLKEVALRTAAMEKKSSKPRVVIITQGANPVIVAVGNKVTLHPAEEIPADKIVDTNGAGDAFVGGFLSQYIQNKGIDESVKCGNYAAGEIIQKHGCTFPKVCKYHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y576</accession>
    <name>A0A0D8Y576_DICVI</name>
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            <fullName evidence="4">MAM domain-containing protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>Rhabditina</taxon>
            <taxon>Rhabditomorpha</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
            <authorList>
                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
            <title>Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention.</title>
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                <person name="McNulty S.N."/>
                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
            </authorList>
            <dbReference type="PubMed" id="26856411"/>
            <dbReference type="DOI" id="10.1038/srep20316"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716175">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5858459at2759"/>
    <dbReference type="Proteomes" id="UP000053766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002336470" description="MAM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17607" checksum="A40C2A362CF081BA" modified="2015-05-27" version="1">MSNLHAVQTLIMVIPILQACHPRFEKELRYLDLYLGIKPDNDGEMPVRDLKYYSSYIPSSNSLDCDFERECLWRNAPSDGLLDTSDFWYFKKIDNKLLPVQIQPGRADIAQGSHLLLAGNASSVADSAVIVSAPVACQRSTGNLTFQFVYSYLNNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <title>Draft genome of the bovine lungworm Dictyocaulus viviparus.</title>
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                <person name="Mitreva M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">HannoverDv2000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="20316" last="20316">
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                <person name="Strube C."/>
                <person name="Rosa B.A."/>
                <person name="Martin J.C."/>
                <person name="Tyagi R."/>
                <person name="Choi Y.J."/>
                <person name="Wang Q."/>
                <person name="Hallsworth Pepin K."/>
                <person name="Zhang X."/>
                <person name="Ozersky P."/>
                <person name="Wilson R.K."/>
                <person name="Sternberg P.W."/>
                <person name="Gasser R.B."/>
                <person name="Mitreva M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">HannoverDv2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KN716173">
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    <dbReference type="Proteomes" id="UP000053766">
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJH51945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000053766"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7984" checksum="685088B1EC9B0111" modified="2015-05-27" version="1">MNKVTDGSNSATFVVDVRKAYTFKVAAATMRGSGPFSPVLAINPDPAGMFGLWFLLSCSNAIVYSILSFRITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D8Y663</accession>
    <name>A0A0D8Y663_DICVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low-density lipoprotein receptor domain class A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DICVIV_02103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyocaulus viviparus</name>
        <name type="common">Bovine lungworm</name>
        <dbReference type="NCBI Taxonomy" id="29172"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Nematoda</taxon>
            <taxon>Chromadorea</taxon>
            <taxon>Rhabditida</taxon>
            <taxon>